Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
HumanPhenoHyperinsulinemia

CPE GUCA1B PRPF6

1.00e-0415143HP:0000842
HumanPhenoAbnormal circulating insulin level

CPE GUCA1B PRPF6

1.17e-0415943HP:0040215
HumanPhenoAbnormal circulating insulin concentration

CPE GUCA1B PRPF6

1.21e-0416143HP:0040214
MousePhenoabnormal circulating calcium level

CPE PRPF6 DEUP1 ZNF106

1.82e-0532384MP:0001562
MousePhenoabnormal calcium level

CPE PRPF6 DEUP1 ZNF106

2.44e-0534884MP:0020879
MousePhenoabnormal calcium ion homeostasis

CPE PRPF6 DEUP1 ZNF106

4.39e-0540484MP:0004231
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

PRPF6 ZNF106 UBTF

4.08e-0522211337071664
Pubmed

FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.

PRPF6 DEUP1 UBTF

5.67e-0524811327926873
Pubmed

Nonsyndromic Retinitis Pigmentosa Overview

GUCA1B PRPF6

2.91e-048111220301590
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPE PRPF6 ZNF106

9.49e-06176113749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellCOVID_vent-Lymphocytic-T_cell-CD4+_T_cell_(ISG_high)|COVID_vent / Disease condition, Lineage, Cell class and subclass

ANKRD30BL CCDC196

4.21e-04126112a1ea8cf6b444a640544d204dfaf5ff219dc31aa9
ToppCelldroplet-Liver-Npc-21m-Epithelial-Hepatocyte_(Midlobular)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GUCA1B DHRS4

5.41e-041431120cd332c128710291a39957d3da22953352f5c382
ToppCelldroplet-Liver-Npc-21m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GUCA1B DHRS4

5.64e-04146112ae43d418492177546b7f85afffb4287d40815f88
ToppCelldroplet-Liver-Npc-21m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GUCA1B DHRS4

5.64e-0414611224e63124116b9a6796ae0495fc69dc6b6af28c38
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPE DEUP1

6.35e-041551128e239470799426ea474a36f57e1b7e0d9365ca5f
ToppCellBL-critical-LOC-Epithelial-FOXN4+|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CPE DEUP1

6.77e-041601123f737451d5713deed20061aa72a9ef77a9a2bc06
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GUCA1B DHRS4

6.94e-04162112f0a92c92c3a6cf9fa11fb279a584e7f328cb7d43
ToppCellCiliated_cells-B-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

DEUP1 ZNF106

7.28e-041661124b1056aad8a99827835242b8ab0c7f2bb84471f1
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPE GUCA1B

7.37e-04167112b94e8ee8c3fcebedd8fcd719eadddc04c7513c50
ToppCellCiliated_cells-A-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

DEUP1 ANKRD30BL

7.63e-041701128b7ef1464ea589886b575ebad5447b085cbdcdba
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPE GUCA1B

7.99e-04174112778e0317c0c63fa4efd74114feb760975b819d92
ToppCellnormal_Lung-Fibroblasts-Mesothelial_cells|normal_Lung / Location, Cell class and cell subclass

CPE RAET1G

8.18e-04176112f31d7234053085a82cf9d55aeedd1e04d34789c3
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_1-Mesothelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CPE RAET1G

8.27e-041771120912a291cff32a4ff8a2d7680ed1a1cd867fb90f
ToppCell10x3'2.3-week_12-13-Mesenchymal_osteo-stroma-early_osteoblast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

CPE DEUP1

8.36e-04178112e32f5ed7a492edfa7073416008b1fcfae6b854ad
ToppCell5'-Airway_Nasal-Mesenchymal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CPE TRIM67

8.55e-041801123dd384b7f3d9582b8fec9fe05100e466e6218b76
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CPE TRIM67

8.55e-0418011227e8bbee388e64dd79d70b160b76d45b1f398006
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CPE TRIM67

8.55e-04180112935c091bbcd6d10b81dc4731779e5bd98205c99f
ToppCellfacs-Large_Intestine-Distal-24m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPE TRIM67

8.74e-04182112398ce074a04f6482470b488f1affae4af7d2ec58
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CPE DEUP1

8.83e-04183112351d575339038bd4a66f408da518c567444208e8
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CPE TRIM67

8.83e-04183112803376f5260de83c48d4f7301278d078a32b3e6e
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CPE TRIM67

8.83e-041831126d98973098c6d20c5305bce6a83a549a7d8dbfba
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CPE TRIM67

8.83e-04183112cc7f5a17b40e8d901885174922e5fa8877643071
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPE TRIM67

8.93e-041841123da93e7d8b62463e307cc0425c47dbd3bef66799
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CPE DEUP1

8.93e-04184112f506d0ee48f39d6f59f19554217dfdf0987cc405
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CPE DEUP1

8.93e-041841128bcb1c4bc8ffef74338cdade926a94711de93c64
ToppCelltumor_Lung-Fibroblasts-Mesothelial_cells|tumor_Lung / Location, Cell class and cell subclass

CPE RAET1G

8.93e-04184112b0a251030d127858e68cf164be158f209a4d720f
ToppCell3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CPE DEUP1

8.93e-04184112d5e44c9085da2a46531ed6db1249bdd88c41b45c
ToppCell3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CPE DEUP1

9.03e-04185112b52e6adfecac93210c27c1d321a5951d54846c40
ToppCell3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine-Neuroendocrine_L.0.7.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CPE DEUP1

9.03e-04185112a34663974868e267495240c0d5c06e390f57b08b
ToppCellControl-Epithelial-Mesothelial|Epithelial / Disease state, Lineage and Cell class

CPE RAET1G

9.03e-041851120af540323c0113203ba6c1a4cb32d2fb9cf79d39
ToppCell3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CPE DEUP1

9.03e-04185112522030941687a268ec2520248df1817b57744a19
ToppCelldroplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CPE DEUP1

9.22e-0418711283930ef55191eff9006113feaeabb3c2fa21fd05
ToppCelldroplet-Lung-18m-Endothelial-arterial_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CPE DEUP1

9.22e-0418711212129e02638c20d9b7c1c6e512d48bfd966e1029
ToppCelldroplet-Lung-nan-18m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPE DEUP1

9.32e-04188112405efea75233ecf70f7d19b630230798d817b7f2
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPE DEUP1

9.42e-041891129da012fdfa9a8d488cab710a463a1d70e89f990c
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_2|356C / Donor, Lineage, Cell class and subclass (all cells)

CPE DHRS4

9.52e-041901124cce4ddb79b7751d0103e10f71156977e0c34439
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF106 UBTF

9.62e-0419111209db184cb90fe282a14474d7217068c58092c6f8
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPE DEUP1

9.62e-041911123307dbccadb09c62b0e1c0235ec89bb294d748c3
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF106 UBTF

9.62e-0419111260c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium-Mesothelium_L.2.6.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CPE RAET1G

9.62e-04191112b7713aba839e7a1f548b7b9d8893067bcc6d7ee7
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF106 UBTF

9.62e-04191112973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CPE ANKRD30BL

9.72e-04192112d0649410cf5eacdb0c1dce70e37c7473ef5fddfa
ToppCell356C-Myeloid-Macrophage|356C / Donor, Lineage, Cell class and subclass (all cells)

CPE DHRS4

9.92e-041941123844e6fb43ae2e0a35ea8ccc1a2e11f40b68bc67
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Stem_cells-retina_progenitors|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

CPE DHRS4

1.00e-0319511206a437459717dc3c41ec343b1ec57cf910ecbdd8
ToppCellMacrophages-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

CPE DHRS4

1.00e-031951122af46e87947c16a7c2c367637e606cfbb8a78528
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Stem_cells|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

CPE DHRS4

1.00e-031951122fa0216ba493d9722324c0a9a0c59c40e72b3c4e
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CPE CCDC196

1.05e-0320011207d942803360e1a1e8e131d6e31c726dd0db1a0b
ToppCell(24)_B_cell_cycling|World / shred on Cell_type and subtype

RAET1G ANKRD30BL

1.07e-03202112a7c9b6b173701348ba35fbb975e0bdd3c1f1d5fe
ComputationalTestis genes.

CPE PRPF6

4.79e-0331042MODULE_72
ComputationalGenes in the cancer module 11.

CPE PRPF6

1.41e-0254042MODULE_11
ComputationalGenes in the cancer module 100.

CPE PRPF6

1.43e-0254442MODULE_100
ComputationalCNS genes.

CPE PRPF6

1.44e-0254642MODULE_137
ComputationalGenes in the cancer module 66.

CPE PRPF6

1.47e-0255242MODULE_66
DrugPirenzepine dihydrochloride [29868-97-1]; Down 200; 9.4uM; PC3; HT_HG-U133A

CPE PRPF6 UBTF

9.70e-051951132071_DN
DrugSuxibuzone [27470-51-5]; Down 200; 9.2uM; PC3; HT_HG-U133A

CPE PRPF6 UBTF

9.85e-051961135806_DN
DrugProparacaine hydrochloride [5875-06-9]; Down 200; 12uM; PC3; HT_HG-U133A

CPE PRPF6 UBTF

1.02e-041981136332_DN
DrugPhenindione [83-12-5]; Down 200; 18uM; PC3; HT_HG-U133A

CPE PRPF6 UBTF

1.03e-041991137289_DN
Drugcidofovir

CPE ZNF106

3.95e-0462112CID000060613
Drugdifluoroboron

CPE UBTF

7.24e-0484112CID000139622
DrugAC1L71LQ

CPE UBTF

1.96e-03139112CID000327967
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

PRPF6 UBTF

2.69e-031631127285_DN
Drug11-cis-retinal

GUCA1B DHRS4

3.59e-03189112CID000001070
DrugEstriol [50-27-1]; Down 200; 13.8uM; MCF7; HT_HG-U133A

CPE UBTF

3.66e-031911127220_DN
DrugAlsterpaullone; Up 200; 10uM; PC3; HT_HG-U133A

CPE GUCA1B

3.66e-031911127078_UP
Drugrosiglitazone maleate; Up 200; 10uM; PC3; HG-U133A

CPE PRPF6

3.66e-03191112430_UP
DrugPronethalol hydrochloride [51-02-5]; Down 200; 15uM; MCF7; HT_HG-U133A

PRPF6 UBTF

3.70e-031921124104_DN
DrugTriamcinolone [124-94-7]; Down 200; 10.2uM; PC3; HT_HG-U133A

PRPF6 UBTF

3.70e-031921122078_DN
DiseaseRetinitis pigmentosa

GUCA1B PRPF6

2.21e-047492cv:C0035334
DiseaseRetinitis Pigmentosa

GUCA1B PRPF6

4.36e-0410492C0035334
DiseaseDisorder of eye

GUCA1B PRPF6

1.79e-0321292C0015397
Diseasecytokine measurement

CPE TRIM67

8.15e-0346192EFO_0004873

Protein segments in the cluster

PeptideGeneStartEntry
DIMVSNKKMDWERKM

DEUP1

26

Q05D60
RMLWMDKEKEESMKE

DHRS4

221

Q9BTZ2
KEEEKEELMEWWKMM

CPE

456

P16870
ERKNKMLRKEMEMLW

CCDC196

101

A0A1B0GTZ2
LWMMKGQIEEQKEMM

PRPF6

711

O94906
RRDKWVMKMLQMDMN

GUCA1B

171

Q9UMX6
AWKLERMMKKTTMDL

ANKRD30BL

51

A7E2S9
VKDMMLGKDDKAWAM

TRIM67

676

Q6ZTA4
RKMKEKWENDKDMTM

RAET1G

166

Q6H3X3
ALKAMEMTWNNMEKK

UBTF

511

P17480
MEDMTMLWNKKSNKS

ZNF106

256

Q9H2Y7