Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled photoreceptor activity	OPN1MW2 OPN1MW3 OPN1MW	2.85e-06	15	38	3	GO:0008020
GeneOntologyMolecularFunction	photoreceptor activity	OPN1MW2 OPN1MW3 OPN1MW	4.24e-06	17	38	3	GO:0009881
GeneOntologyBiologicalProcess	positive regulation of lipid biosynthetic process	PLA2G4A ZNF750 ADGRF5 CCN1	6.41e-05	121	37	4	GO:0046889
GeneOntologyBiologicalProcess	positive regulation of sphingolipid biosynthetic process	ZNF750 CCN1	8.71e-05	8	37	2	GO:0090154
GeneOntologyBiologicalProcess	positive regulation of ceramide biosynthetic process	ZNF750 CCN1	8.71e-05	8	37	2	GO:2000304
GeneOntologyBiologicalProcess	phototransduction	OPN1MW2 OPN1MW3 OPN1MW	1.17e-04	53	37	3	GO:0007602
GeneOntologyBiologicalProcess	negative regulation of epithelial to mesenchymal transition	ZNF750 TSC2 IL17RD	1.38e-04	56	37	3	GO:0010719
GeneOntologyBiologicalProcess	detection of visible light	OPN1MW2 OPN1MW3 OPN1MW	1.45e-04	57	37	3	GO:0009584
GeneOntologyBiologicalProcess	positive regulation of lipid metabolic process	PLA2G4A ZNF750 ADGRF5 CCN1	2.12e-04	165	37	4	GO:0045834
GeneOntologyBiologicalProcess	regulation of ceramide biosynthetic process	ZNF750 CCN1	2.81e-04	14	37	2	GO:2000303
GeneOntologyBiologicalProcess	ceramide biosynthetic process	ZNF750 CCN1 GAL3ST1	3.03e-04	73	37	3	GO:0046513
GeneOntologyBiologicalProcess	detection of light stimulus	OPN1MW2 OPN1MW3 OPN1MW	3.55e-04	77	37	3	GO:0009583
GeneOntologyBiologicalProcess	regulation of sphingolipid biosynthetic process	ZNF750 CCN1	3.70e-04	16	37	2	GO:0090153
GeneOntologyCellularComponent	photoreceptor disc membrane	OPN1MW2 OPN1MW3 OPN1MW	1.40e-05	26	38	3	GO:0097381
GeneOntologyCellularComponent	non-motile cilium	OPN1MW2 CDH23 OPN1MW3 OPN1MW	4.31e-04	196	38	4	GO:0097730
GeneOntologyCellularComponent	photoreceptor outer segment	OPN1MW2 OPN1MW3 OPN1MW	1.07e-03	111	38	3	GO:0001750
Domain	Opsin_red/grn	OPN1MW3 OPN1MW	1.08e-05	3	36	2	IPR000378
Domain	OPSIN	OPN1MW3 OPN1MW	1.61e-04	10	36	2	PS00238
Domain	Opsin	OPN1MW3 OPN1MW	1.97e-04	11	36	2	IPR001760
Pathway	REACTOME_THE_RETINOID_CYCLE_IN_CONES_DAYLIGHT_VISION	OPN1MW2 OPN1MW3	9.10e-05	8	26	2	MM14880
Pathway	REACTOME_OPSINS	OPN1MW2 OPN1MW3	1.46e-04	10	26	2	MM15063
Pubmed	Human L- and M-opsins restore M-cone function in a mouse model for human blue cone monochromacy.	OPN1MW2 OPN1MW3 OPN1MW	4.81e-09	4	38	3	29386880
Pubmed	Molecular genetics of human color vision: the genes encoding blue, green, and red pigments.	OPN1MW2 OPN1MW3 OPN1MW	1.20e-08	5	38	3	2937147
Pubmed	Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins.	PLA2G4A KSR1 IL17RD	1.44e-07	10	38	3	19114553
Pubmed	Mutant Cockayne syndrome group B protein inhibits repair of DNA topoisomerase I-DNA covalent complex.	ERCC6 PGBD3	1.16e-06	2	38	2	21143350
Pubmed	Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors.	OPN1MW2 OPN1MW	1.16e-06	2	38	2	28402104
Pubmed	Defective colour vision associated with a missense mutation in the human green visual pigment gene.	OPN1MW2 OPN1MW	1.16e-06	2	38	2	1302020
Pubmed	Subcellular localization and role of lipin-1 in human macrophages.	LPIN1 PLA2G4A	1.16e-06	2	38	2	21478406
Pubmed	Quantitative imaging mass spectrometry of renal sulfatides: validation by classical mass spectrometric methods.	PAX8 GAL3ST1	1.16e-06	2	38	2	25274613
Pubmed	What role (if any) does the highly conserved CSB-PGBD3 fusion protein play in Cockayne syndrome?	ERCC6 PGBD3	1.16e-06	2	38	2	23369858
Pubmed	Position of a 'green-red' hybrid gene in the visual pigment array determines colour-vision phenotype.	OPN1MW2 OPN1MW	1.16e-06	2	38	2	10319869
Pubmed	The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.	ERCC6 PGBD3	1.16e-06	2	38	2	22483866
Pubmed	An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome.	ERCC6 PGBD3	1.16e-06	2	38	2	18369450
Pubmed	Molecular determinants of human red/green color discrimination.	OPN1MW2 OPN1MW	3.48e-06	3	38	2	8185948
Pubmed	Sulfatides are required for renal adaptation to chronic metabolic acidosis.	PAX8 GAL3ST1	3.48e-06	3	38	2	23716689
Pubmed	X-linked cone dystrophy caused by mutation of the red and green cone opsins.	OPN1MW2 OPN1MW	3.48e-06	3	38	2	20579627
Pubmed	Cockayne syndrome group B (Csb) and group a (Csa) deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice.	CDH23 ERCC6	3.48e-06	3	38	2	25762674
Pubmed	Expression of red/green-cone opsin mutants K82E, P187S, M273K result in unique pathobiological perturbations to cone structure and function.	OPN1MW2 OPN1MW3	3.48e-06	3	38	2	38410159
Pubmed	Chloride-dependent spectral tuning mechanism of L-group cone visual pigments.	OPN1MW2 OPN1MW3	3.48e-06	3	38	2	23350963
Pubmed	Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance.	OPN1MW2 OPN1MW3	3.48e-06	3	38	2	20471354
Pubmed	Tethering of the conserved piggyBac transposase fusion protein CSB-PGBD3 to chromosomal AP-1 proteins regulates expression of nearby genes in humans.	ERCC6 PGBD3	3.48e-06	3	38	2	23028371
Pubmed	Multiple hypothalamic cell populations encoding distinct visual information.	OPN1MW2 OPN1MW3	3.48e-06	3	38	2	21224225
Pubmed	Gene-based Therapy in a Mouse Model of Blue Cone Monochromacy.	OPN1MW2 OPN1MW3	3.48e-06	3	38	2	28751656
Pubmed	Circadian Regulation of the Rod Contribution to Mesopic Vision in Mice.	OPN1MW2 OPN1MW3	3.48e-06	3	38	2	36216501
Pubmed	Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.	PRDM16 SETBP1	3.48e-06	3	38	2	16582916
Pubmed	Rescue of M-cone Function in Aged Opn1mw-/- Mice, a Model for Late-Stage Blue Cone Monochromacy.	OPN1MW2 OPN1MW3	3.48e-06	3	38	2	31469404
Pubmed	The molecular genetics and evolution of red and green color vision in vertebrates.	OPN1MW2 OPN1MW3	3.48e-06	3	38	2	11545071
Pubmed	Mechanisms of spectral tuning in the mouse green cone pigment.	OPN1MW2 OPN1MW3	3.48e-06	3	38	2	9238068
Pubmed	Emergence of novel color vision in mice engineered to express a human cone photopigment.	OPN1MW2 OPN1MW3	3.48e-06	3	38	2	17379811
Pubmed	Spectral tuning of a circadian photopigment in a subterranean 'blind' mammal (Spalax ehrenbergi).	OPN1MW2 OPN1MW3	3.48e-06	3	38	2	10567724
Pubmed	Extensive cone-dependent spectral opponency within a discrete zone of the lateral geniculate nucleus supporting mouse color vision.	OPN1MW2 OPN1MW3	3.48e-06	3	38	2	34111401
Pubmed	Co-expression of murine opsins facilitates identifying the site of cone adaptation.	OPN1MW2 OPN1MW3	3.48e-06	3	38	2	12511072
Pubmed	Cysteine-rich 61 (CCN1) enhances chemotactic migration, transendothelial cell migration, and intravasation by concomitantly up-regulating chemokine receptor 1 and 2.	CCN1 CXCR1	3.48e-06	3	38	2	18025257
Pubmed	The Pem homeobox gene is X-linked and exclusively expressed in extraembryonic tissues during early murine development.	OPN1MW2 OPN1MW3	3.48e-06	3	38	2	7958444
Pubmed	Genetically engineered mice with an additional class of cone photoreceptors: implications for the evolution of color vision.	OPN1MW2 OPN1MW3	3.48e-06	3	38	2	14500905
Pubmed	Melanopsin-driven increases in maintained activity enhance thalamic visual response reliability across a simulated dawn.	OPN1MW2 OPN1MW3	6.96e-06	4	38	2	26438865
Pubmed	Light/dark translocation of alphatransducin in mouse photoreceptor cells expressing G90D mutant opsin.	OPN1MW2 OPN1MW3	6.96e-06	4	38	2	17249565
Pubmed	An mTORC1-mediated negative feedback loop constrains amino acid-induced FLCN-Rag activation in renal cells with TSC2 loss.	TSC2 PAX8	6.96e-06	4	38	2	36357396
Pubmed	Structural and functional rescue of cones carrying the most common cone opsin C203R missense mutation.	OPN1MW2 OPN1MW3	6.96e-06	4	38	2	38060327
Pubmed	Contribution of M-opsin-based color vision to refractive development in mice.	OPN1MW2 OPN1MW3	6.96e-06	4	38	2	34126082
Pubmed	Physiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings.	OPN1MW2 OPN1MW3	6.96e-06	4	38	2	16567464
Pubmed	Visual responses in the dorsal lateral geniculate nucleus at early stages of retinal degeneration in rd1 PDE6β mice.	OPN1MW2 OPN1MW3	6.96e-06	4	38	2	31461375
Pubmed	S-opsin knockout mice with the endogenous M-opsin gene replaced by an L-opsin variant.	OPN1MW2 OPN1MW3	6.96e-06	4	38	2	24801621
Pubmed	Murine and bovine blue cone pigment genes: cloning and characterization of two new members of the S family of visual pigments.	OPN1MW2 OPN1MW3	6.96e-06	4	38	2	8088841
Pubmed	Modulation of Fast Narrowband Oscillations in the Mouse Retina and dLGN According to Background Light Intensity.	OPN1MW2 OPN1MW3	6.96e-06	4	38	2	28103478
Pubmed	Melanopsin Contributions to the Representation of Images in the Early Visual System.	OPN1MW2 OPN1MW3	6.96e-06	4	38	2	28528909
Pubmed	Molecular biology of the visual pigments.	OPN1MW2 OPN1MW	6.96e-06	4	38	2	3303660
Pubmed	Cones Support Alignment to an Inconsistent World by Suppressing Mouse Circadian Responses to the Blue Colors Associated with Twilight.	OPN1MW2 OPN1MW3	6.96e-06	4	38	2	31846668
Pubmed	Melanopsin-driven light adaptation in mouse vision.	OPN1MW2 OPN1MW3	6.96e-06	4	38	2	25308073
Pubmed	TLR-4 mediated group IVA phospholipase A(2) activation is phosphatidic acid phosphohydrolase 1 and protein kinase C dependent.	LPIN1 PLA2G4A	6.96e-06	4	38	2	19230851
Pubmed	mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Müller glia.	OPN1MW2 OPN1MW3 TSC2	1.16e-05	40	38	3	34677125
Pubmed	Noncoding Mutations in a Thyroid Hormone Receptor Gene That Impair Cone Photoreceptor Function.	OPN1MW2 OPN1MW3	1.16e-05	5	38	2	36631163
Pubmed	Using Silent Substitution to Track the Mesopic Transition From Rod- to Cone-Based Vision in Mice.	OPN1MW2 OPN1MW3	1.16e-05	5	38	2	26818794
Pubmed	A common integration locus in type B retrovirus-induced thymic lymphomas.	OPN1MW2 OPN1MW3	1.16e-05	5	38	2	1333116
Pubmed	Melanopsin-based brightness discrimination in mice and humans.	OPN1MW2 OPN1MW3	1.16e-05	5	38	2	22633808
Pubmed	The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning.	OPN1MW2 OPN1MW3	1.16e-05	5	38	2	11055434
Pubmed	A distinct contribution of short-wavelength-sensitive cones to light-evoked activity in the mouse pretectal olivary nucleus.	OPN1MW2 OPN1MW3	1.16e-05	5	38	2	22090509
Pubmed	Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions.	OPN1MW2 OPN1MW3	1.16e-05	5	38	2	10723722
Pubmed	Enhancer/promoter activities of the long/middle wavelength-sensitive opsins of vertebrates mediated by thyroid hormone receptor β2 and COUP-TFII.	OPN1MW2 OPN1MW3	1.16e-05	5	38	2	24058409
Pubmed	Variations in photoreceptor throughput to mouse visual cortex and the unique effects on tuning.	OPN1MW2 OPN1MW3	1.16e-05	5	38	2	34099749
Pubmed	Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors.	OPN1MW2 OPN1MW3	1.16e-05	5	38	2	27033727
Pubmed	Functional comparison of rod and cone Gα(t) on the regulation of light sensitivity.	OPN1MW2 OPN1MW3	1.74e-05	6	38	2	23288843
Pubmed	Reduced levels of dystrophin associated proteins in the brains of mice deficient for Dp71.	OPN1MW2 OPN1MW3	1.74e-05	6	38	2	8872469
Pubmed	A thyroid hormone receptor that is required for the development of green cone photoreceptors.	OPN1MW2 OPN1MW3	1.74e-05	6	38	2	11138006
Pubmed	GRK1-dependent phosphorylation of S and M opsins and their binding to cone arrestin during cone phototransduction in the mouse retina.	OPN1MW2 OPN1MW	1.74e-05	6	38	2	12853434
Pubmed	Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase.	OPN1MW2 OPN1MW3	1.74e-05	6	38	2	10395695
Pubmed	Transient expression of thyroid hormone nuclear receptor TRbeta2 sets S opsin patterning during cone photoreceptor genesis.	OPN1MW2 OPN1MW3	1.74e-05	6	38	2	17436273
Pubmed	Telomere-related markers for the pseudoautosomal region of the mouse genome.	OPN1MW2 OPN1MW3	1.74e-05	6	38	2	1549575
Pubmed	Diastereomer-specific quantification of bioactive hexosylceramides from bacteria and mammals.	PAX8 GAL3ST1	1.74e-05	6	38	2	28373486
Pubmed	mTORC1 accelerates retinal development via the immunoproteasome.	OPN1MW2 OPN1MW3 TSC2	1.77e-05	46	38	3	29950673
Pubmed	Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression.	OPN1MW2 OPN1MW3	2.43e-05	7	38	2	8378320
Pubmed	Retarded developmental expression and patterning of retinal cone opsins in hypothyroid mice.	OPN1MW2 OPN1MW3	2.43e-05	7	38	2	18974269
Pubmed	Rod Photoreceptor Activation Alone Defines the Release of Dopamine in the Retina.	OPN1MW2 OPN1MW3	2.43e-05	7	38	2	30799247
Pubmed	Activation of the blue opsin gene in cone photoreceptor development by retinoid-related orphan receptor beta.	OPN1MW2 OPN1MW3	2.43e-05	7	38	2	16574740
Pubmed	Rods progressively escape saturation to drive visual responses in daylight conditions.	OPN1MW2 OPN1MW3	2.43e-05	7	38	2	29180667
Pubmed	Genetic and physical mapping of a gene encoding a methyl CpG binding protein, Mecp2, to the mouse X chromosome.	OPN1MW2 OPN1MW3	2.43e-05	7	38	2	8001979
Pubmed	NeuroD1 regulates expression of thyroid hormone receptor 2 and cone opsins in the developing mouse retina.	OPN1MW2 OPN1MW3	2.43e-05	7	38	2	18199774
Pubmed	Mapping of the murine tbl1 gene reveals a new rearrangement between mouse and human X Chromosomes.	OPN1MW2 OPN1MW3	2.43e-05	7	38	2	9880679
Pubmed	Cloning and distribution of myosin 3B in the mouse retina: differential distribution in cone outer segments.	OPN1MW2 OPN1MW3	2.43e-05	7	38	2	19332056
Pubmed	X-chromosome gene order in different Mus species crosses.	OPN1MW2 OPN1MW3	3.24e-05	8	38	2	3416629
Pubmed	The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: subserving RPGR function and participating in disk morphogenesis.	OPN1MW2 OPN1MW3	3.24e-05	8	38	2	12651948
Pubmed	Transcriptional profiling of murine retinas undergoing semi-synchronous cone photoreceptor differentiation.	OPN1MW2 OPN1MW3	3.24e-05	8	38	2	31163126
Pubmed	Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors.	OPN1MW2 OPN1MW3	3.24e-05	8	38	2	20203194
Pubmed	Tubby is required for trafficking G protein-coupled receptors to neuronal cilia.	OPN1MW2 OPN1MW3	3.24e-05	8	38	2	23351594
Pubmed	Localization of the mdx mutation within the mouse dystrophin gene.	OPN1MW2 OPN1MW3	3.24e-05	8	38	2	2903046
Pubmed	A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3).	OPN1MW2 OPN1MW3	3.24e-05	8	38	2	10725384
Pubmed	Retinoid X receptor (gamma) is necessary to establish the S-opsin gradient in cone photoreceptors of the developing mouse retina.	OPN1MW2 OPN1MW3	3.24e-05	8	38	2	16043864
Pubmed	Nr2e3 functional domain ablation by CRISPR-Cas9D10A identifies a new isoform and generates retinitis pigmentosa and enhanced S-cone syndrome models.	OPN1MW2 OPN1MW3	3.24e-05	8	38	2	33007388
Pubmed	Genetic mapping on the mouse X chromosome of human cDNA clones for the fragile X and Hunter syndromes.	OPN1MW2 OPN1MW3	3.24e-05	8	38	2	1572654
Pubmed	Linkage of amelogenin (Amel) to the distal portion of the mouse X chromosome.	OPN1MW2 OPN1MW3	3.24e-05	8	38	2	1675194
Pubmed	Two transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal development.	OPN1MW2 OPN1MW3	3.24e-05	8	38	2	21813673
Pubmed	ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation.	AAAS ERCC6 CNOT4	3.75e-05	59	38	3	34108663
Pubmed	Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium.	OPN1MW2 OPN1MW3	4.16e-05	9	38	2	14742273
Pubmed	A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction.	OPN1MW2 OPN1MW3	4.16e-05	9	38	2	27669145
Pubmed	Close linkage of the murine locus bare patches to the X-linked visual pigment gene: implications for mapping human X-linked dominant chondrodysplasia punctata.	OPN1MW2 OPN1MW3	4.16e-05	9	38	2	1973136
Pubmed	Feedback induction of a photoreceptor-specific isoform of retinoid-related orphan nuclear receptor β by the rod transcription factor NRL.	OPN1MW2 OPN1MW3	4.16e-05	9	38	2	25296752
Pubmed	Comparative mapping of the actin-binding protein 280 genes in human and mouse.	OPN1MW2 OPN1MW3	4.16e-05	9	38	2	8088838
Pubmed	Distinct functions of photoreceptor cell-specific nuclear receptor, thyroid hormone receptor beta2 and CRX in one photoreceptor development.	OPN1MW2 OPN1MW3	4.16e-05	9	38	2	12407160
Pubmed	ZBED4, a cone and Müller cell protein in human retina, has a different cellular expression in mouse.	OPN1MW2 OPN1MW3	4.16e-05	9	38	2	21850176
Pubmed	Top2b is involved in the formation of outer segment and synapse during late-stage photoreceptor differentiation by controlling key genes of photoreceptor transcriptional regulatory network.	OPN1MW2 OPN1MW3	4.16e-05	9	38	2	28370415
Pubmed	IFT20 is required for opsin trafficking and photoreceptor outer segment development.	OPN1MW2 OPN1MW3	4.16e-05	9	38	2	21307337
Cytoband	7q22	ZKSCAN5 CNOT4	4.60e-04	38	38	2	7q22
Cytoband	Ensembl 112 genes in cytogenetic band chrXq28	OPN1MW2 OPN1MW3 OPN1MW	7.37e-04	213	38	3	chrXq28
Cytoband	2q35	ZNF142 CXCR1	1.97e-03	79	38	2	2q35
Cytoband	Ensembl 112 genes in cytogenetic band chr4q32	FNIP2 DDX60	4.48e-03	120	38	2	chr4q32
Cytoband	Ensembl 112 genes in cytogenetic band chr2q35	ZNF142 CXCR1	5.15e-03	129	38	2	chr2q35
GeneFamily	Opsin receptors	OPN1MW2 OPN1MW3 OPN1MW	6.74e-07	11	30	3	215
GeneFamily	CD molecules\|I-set domain containing\|Immunoglobulin like domain containing\|Interleukin receptors\|TIR domain containing	IL17RD CXCR1	2.20e-03	42	30	2	602
Drug	azotochelin	ERCC6 PGBD3	2.57e-06	2	37	2	CID000193592
Drug	Propafenone hydrochloride [34183-22-7]; Up 200; 10.6uM; MCF7; HT_HG-U133A	CDADC1 LPIN1 ZNF750 ADGRF5 DDX60	1.45e-05	193	37	5	5437_UP
Drug	Epiandrosterone [481-29-8]; Up 200; 13.8uM; PC3; HT_HG-U133A	LPIN1 KSR1 PAX8 GNRHR CNOT4	1.49e-05	194	37	5	4626_UP
Drug	Chlormezanone [80-77-3]; Up 200; 14.6uM; PC3; HT_HG-U133A	LPIN1 KSR1 ADGRF5 PAX8 ZKSCAN5	1.60e-05	197	37	5	4636_UP
Drug	Cloperastine hydrochloride [14984-68-0]; Up 200; 11uM; HL60; HT_HG-U133A	ZNF750 ADGRF5 CCN1 PAX8 GNRHR	1.64e-05	198	37	5	2549_UP
Drug	cyclosporin B	ERCC6 PGBD3	3.84e-05	6	37	2	CID006450331
Disease	blue cone monochromacy (implicated_via_orthology)	OPN1MW2 OPN1MW3 OPN1MW	7.87e-09	4	38	3	DOID:0050679 (implicated_via_orthology)
Disease	Idiopathic hypogonadotropic hypogonadism	IL17RD GNRHR	2.44e-04	18	38	2	C0342384
Disease	QRS complex, QRS duration	PRDM16 SETBP1	1.54e-03	45	38	2	EFO_0005054, EFO_0005055

Protein segments in the cluster

Peptide	Gene	Start	Entry
HIPLYFVNAQFPRFS	AAAS	481	Q9NRG9
LNIPFPYNFHDFQFC	ADAM7	391	Q9H2U9
NYNCPHANEAAFPFY	CCN1	356	O00622
TFFPFHEYFANAPQP	AQR	966	O60306
PNFKHFGFYRSNPEQ	CDADC1	291	Q9BWV3
NRLPFFTNHFFDTYL	CDH23	26	Q9H251
FFACFAAANPGYPFH	OPN1MW3	286	P0DN78
PFNAFPHAASVYGQF	PAX8	341	Q06710
FFACFAAANPGYPFH	OPN1MW2	286	P0DN77
HPGQYHFVFNNFFTS	ERCC6	811	P0DP91
FPSIKNESNYHPFFF	IL17RD	166	Q8NFM7
FPPKFQDAHFEFYQS	DDX60	1496	Q8IY21
FNFPAAYFIHHRQQF	KSR1	486	Q8IVT5
LFFPNTEPFYAAFGN	LPIN1	786	Q14693
SQFGPINNHFFYESF	MTPAP	96	Q9NVV4
FFACFAAANPGYPFH	OPN1MW	286	P04001
FAFPNGRNDFDYPTF	GAL3ST1	106	Q99999
HFFFLFAFLNPCFDP	GNRHR	306	P30968
HFPDSFQATPFCFNQ	COLCA2	16	A8K830
QRNFQDFFFSHFPLF	FNIP2	326	Q9P278
FFLFRQAYHPNNSSP	CXCR1	171	P25024
SPFSTFNFQYPNQAF	PLA2G4A	676	P47712
EAHPGQYHFVFNNFF	PGBD3	341	Q8N328
LPDFLDYFSFNFPNS	RSBN1L	411	Q6PCB5
LRPFYFAVHPDFFGQ	TCAIM	36	Q8N3R3
YHSAFPFQFLPNFPH	PRDM16	721	Q9HAZ2
FHALPSPQYFVDFVF	SLC39A4	196	Q6P5W5
YTFEFHFLPNPYFRN	NAP1L3	356	Q99457
SHPETYQQRFVFPYF	ADGRF5	861	Q8IZF2
FPQFQQHRAVYNSFS	CNOT4	476	O95628
APSPATYDHYRFFQQ	ZNF750	296	Q32MQ0
FQSYPFDFLEFLNHQ	ZNF865	26	P0CJ78
YANYFQHPFSGPSVF	ZCCHC14	806	Q8WYQ9
FCPFATFNPVAYQDH	ZNF142	376	P52746
NNFVYNSPRGYFHTF	WASL	96	O00401
FYHENPYPSIFRINF	SETBP1	976	Q9Y6X0
YNPPTFETFYQRFRH	ZKSCAN5	41	Q9Y2L8
NPSFVFLQLYHSPFF	TSC2	1496	P49815
YQHRFNFFPENPAFS	YTHDF1	116	Q9BYJ9