Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphatidylinositol phospholipase C activity	PLCD3 PLCH2 PLCL2 PLCB1 PLCD1 PLCL1	1.92e-08	26	137	6	GO:0004435
GeneOntologyMolecularFunction	phospholipase C activity	PLCD3 PLCH2 PLCL2 PLCB1 PLCD1 PLCL1	3.90e-08	29	137	6	GO:0004629
GeneOntologyMolecularFunction	GTPase activator activity	DOCK2 DOCK3 DOCK4 MYO9B LARS1 SYNGAP1 ARHGAP1 PLCB1 AGAP2 NCKAP1L	2.33e-05	279	137	10	GO:0005096
GeneOntologyMolecularFunction	phosphoric diester hydrolase activity	PLCD3 PLCH2 PLCL2 PLCB1 PLCD1 PLCL1	5.54e-05	97	137	6	GO:0008081
GeneOntologyMolecularFunction	phospholipase activity	PLCD3 PLCH2 PLCL2 PLCB1 PLCD1 PLCL1	1.36e-04	114	137	6	GO:0004620
GeneOntologyMolecularFunction	lipase activity	PLCD3 PLCH2 PLCL2 PLCB1 PLCD1 PLCL1	3.83e-04	138	137	6	GO:0016298
GeneOntologyBiologicalProcess	phosphatidylinositol-mediated signaling	PIK3C2G PLCH2 PLCB1 PLCD1	1.68e-05	24	135	4	GO:0048015
Domain	EF-hand_like	PLCD3 PLCH2 PLCL2 PLCB1 PLCD1 PLCL1	6.33e-10	15	136	6	PF09279
Domain	PI-PLC-Y	PLCD3 PLCH2 PLCL2 PLCB1 PLCD1 PLCL1	6.33e-10	15	136	6	PF00387
Domain	PLCYc	PLCD3 PLCH2 PLCL2 PLCB1 PLCD1 PLCL1	6.33e-10	15	136	6	SM00149
Domain	PLipase_C_Pinositol-sp_Y	PLCD3 PLCH2 PLCL2 PLCB1 PLCD1 PLCL1	6.33e-10	15	136	6	IPR001711
Domain	PIPLC_Y_DOMAIN	PLCD3 PLCH2 PLCL2 PLCB1 PLCD1 PLCL1	6.33e-10	15	136	6	PS50008
Domain	PI-PLC_fam	PLCD3 PLCH2 PLCL2 PLCB1 PLCD1 PLCL1	6.33e-10	15	136	6	IPR001192
Domain	PLC_EF-hand-like	PLCD3 PLCH2 PLCL2 PLCB1 PLCD1 PLCL1	6.33e-10	15	136	6	IPR015359
Domain	PI-PLC-X	PLCD3 PLCH2 PLCL2 PLCB1 PLCD1 PLCL1	2.30e-09	18	136	6	PF00388
Domain	PLCXc	PLCD3 PLCH2 PLCL2 PLCB1 PLCD1 PLCL1	2.30e-09	18	136	6	SM00148
Domain	PIPLC_X_DOMAIN	PLCD3 PLCH2 PLCL2 PLCB1 PLCD1 PLCL1	3.35e-09	19	136	6	PS50007
Domain	PLipase_C_PInositol-sp_X_dom	PLCD3 PLCH2 PLCL2 PLCB1 PLCD1 PLCL1	3.35e-09	19	136	6	IPR000909
Domain	-	RPGRIP1L CAPN6 SYNGAP1 PLCD3 PIK3C2G PLCH2 PLCL2 PLCB1 PLCD1 PLCL1 ASCC3	1.11e-08	148	136	11	2.60.40.150
Domain	-	PLCD3 PLCH2 PLCL2 PLCB1 PLCD1 PLCL1	2.11e-08	25	136	6	3.20.20.190
Domain	PLC-like_Pdiesterase_TIM-brl	PLCD3 PLCH2 PLCL2 PLCB1 PLCD1 PLCL1	2.11e-08	25	136	6	IPR017946
Domain	C2_dom	RPGRIP1L CAPN6 SYNGAP1 PLCD3 PIK3C2G PLCH2 PLCL2 PLCB1 PLCD1 PLCL1 ASCC3	3.23e-08	164	136	11	IPR000008
Domain	C2	RPGRIP1L CAPN6 SYNGAP1 PLCD3 PIK3C2G PLCH2 PLCL2 PLCB1 PLCD1 PLCL1	4.10e-08	131	136	10	PF00168
Domain	C2	RPGRIP1L CAPN6 SYNGAP1 PLCD3 PIK3C2G PLCH2 PLCL2 PLCB1 PLCD1 PLCL1	6.28e-08	137	136	10	SM00239
Domain	C2	RPGRIP1L CAPN6 SYNGAP1 PLCD3 PIK3C2G PLCH2 PLCL2 PLCB1 PLCD1 PLCL1	8.83e-08	142	136	10	PS50004
Domain	DOCK_N	DOCK2 DOCK3 DOCK4	3.74e-06	5	136	3	PF16172
Domain	DOCK_N	DOCK2 DOCK3 DOCK4	3.74e-06	5	136	3	IPR032376
Domain	PH	TEX2 SYNGAP1 PLCD3 PLCH2 PLCL2 IRS2 PLCD1 PLCL1 PHLDB2 DNM2 AGAP2	6.13e-06	278	136	11	SM00233
Domain	PH_domain	TEX2 SYNGAP1 PLCD3 PLCH2 PLCL2 IRS2 PLCD1 PLCL1 PHLDB2 DNM2 AGAP2	6.56e-06	280	136	11	IPR001849
Domain	ARM-type_fold	DOCK2 DOCK3 USP34 MYBBP1A CLASP1 USP9X TTI2 APC PSMD5 FRYL ARMCX1 PIK3C2G	7.13e-06	339	136	12	IPR016024
Domain	PH_12	PLCH2 PLCL2 PLCL1	7.43e-06	6	136	3	PF16457
Domain	PH_DOMAIN	SYNGAP1 PLCD3 PLCH2 PLCL2 IRS2 PLCD1 PLCL1 PHLDB2 DNM2 AGAP2	3.83e-05	279	136	10	PS50003
Domain	DHR-1_domain	DOCK2 DOCK3 DOCK4	5.97e-05	11	136	3	IPR027007
Domain	DHR_2	DOCK2 DOCK3 DOCK4	5.97e-05	11	136	3	PS51651
Domain	DHR_1	DOCK2 DOCK3 DOCK4	5.97e-05	11	136	3	PS51650
Domain	DHR-2	DOCK2 DOCK3 DOCK4	5.97e-05	11	136	3	PF06920
Domain	DOCK	DOCK2 DOCK3 DOCK4	5.97e-05	11	136	3	IPR026791
Domain	DOCK_C	DOCK2 DOCK3 DOCK4	5.97e-05	11	136	3	IPR010703
Domain	DOCK-C2	DOCK2 DOCK3 DOCK4	5.97e-05	11	136	3	PF14429
Domain	DHR-2	DOCK2 DOCK3 DOCK4	5.97e-05	11	136	3	IPR027357
Domain	PH_dom-like	SYNGAP1 TYK2 PLCD3 PLCH2 PLCL2 PLCB1 IRS2 PLCD1 PLCL1 PHLDB2 DNM2 AGAP2	6.73e-05	426	136	12	IPR011993
Domain	Requiem/DPF_N_dom	DPF1 DPF3	1.57e-04	3	136	2	IPR025750
Domain	Requiem_N	DPF1 DPF3	1.57e-04	3	136	2	PF14051
Domain	-	SYNGAP1 PLCD3 PLCH2 PLCL2 IRS2 PLCD1 PLCL1 PHLDB2 DNM2 AGAP2	5.91e-04	391	136	10	2.30.29.30
Domain	E1_dh	BCKDHA OGDH	7.75e-04	6	136	2	PF00676
Domain	DH_E1	BCKDHA OGDH	7.75e-04	6	136	2	IPR001017
Domain	ARM-like	DOCK2 CLASP1 USP9X TTI2 APC PSMD5 FRYL ARMCX1	8.22e-04	270	136	8	IPR011989
Domain	PH	SYNGAP1 PLCH2 IRS2 PLCD1 PHLDB2 DNM2 AGAP2	1.46e-03	229	136	7	PF00169
Pathway	WP_GPR40_PATHWAY	PLCD3 PLCB1 PLCD1 PLCL1	3.45e-06	15	103	4	M39526
Pathway	WP_PHOSPHOINOSITIDES_METABOLISM	PLCD3 PIK3C2G PLCH2 PLCB1 PLCD1	2.79e-05	49	103	5	M40046
Pathway	REACTOME_SYNTHESIS_OF_IP3_AND_IP4_IN_THE_CYTOSOL	PLCD3 PLCH2 PLCB1 PLCD1	3.55e-05	26	103	4	M27053
Pathway	REACTOME_SYNTHESIS_OF_IP3_AND_IP4_IN_THE_CYTOSOL	PLCD3 PLCH2 PLCB1 PLCD1	4.81e-05	28	103	4	MM14711
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	AKAP6 DOCK3 USP34 AHCYL1 ERG VPS45 USP9X BACH1 LARS1 APC PSMD5 LRP1B ZNF365 SYNGAP1 ARHGAP1 PCSK6 NEUROD6 DNM2 AGAP2 B4GALT3	2.67e-07	1285	141	20	35914814
Pubmed	Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.	PLCD3 PLCH2 PLCB1 PLCD1	7.58e-07	18	141	4	1979339
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	AHCYL1 ZBTB20 USP9X CAPN6 APC LRP1B CES2 DPP9 B3GNT2 PLCB1 IRS2 PLCL1 KDM1A DNM2	1.77e-06	730	141	14	34857952
Pubmed	Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.	MANBA IRF8 TYK2 PLCL2 MYB AGAP2	2.00e-06	91	141	6	21833088
Pubmed	Control of developmentally primed erythroid genes by combinatorial co-repressor actions.	TCF4 NCOR2 CBFA2T2 KDM1A	6.54e-06	30	141	4	26593974
Pubmed	Expression of phospholipase C isozymes by murine B lymphocytes.	PLCD3 PLCB1 PLCD1	7.67e-06	10	141	3	2033248
Pubmed	Genetic mapping of the human and mouse phospholipase C genes.	IRF8 PLCD3 PLCB1 PLCD1	9.67e-06	33	141	4	8672127
Pubmed	A myelin-related transcriptomic profile is shared by Pitt-Hopkins syndrome models and human autism spectrum disorder.	TCF4 APC CSPG4	1.05e-05	11	141	3	32015540
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	AKAP6 USP34 EMC1 TEX2 LARS1 ADCY9 GPR107 PLCH2 MED12L PLCB1 KDM1A	1.13e-05	529	141	11	14621295
Pubmed	Phospholipase C isoforms are localized at the cleavage furrow during cytokinesis.	PLCB1 PLCD1	1.63e-05	2	141	2	17041247
Pubmed	Mutation of a nuclear respiratory factor 2 binding site in the 5' untranslated region of the ADSL gene in three patients with adenylosuccinate lyase deficiency.	ADSL GABPB1	1.63e-05	2	141	2	12016589
Pubmed	Phospholipase C-related but catalytically inactive protein acts as a positive regulator of insulin signalling in adipocytes.	PLCL2 PLCL1	1.63e-05	2	141	2	34859819
Pubmed	Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2.	ERG IRS2	1.63e-05	2	141	2	32015092
Pubmed	Expression and function of phospholipase C in breast carcinoma.	PLCD3 PLCD1	1.63e-05	2	141	2	19344632
Pubmed	Inactivation of Itf2 promotes intestinal tumorigenesis in Apc(Min/+) mice.	TCF4 APC	1.63e-05	2	141	2	25869068
Pubmed	Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice.	PLCL2 PLCL1	1.63e-05	2	141	2	31589911
Pubmed	Aberrant protein expression of transcription factors BACH1 and ERG, both encoded on chromosome 21, in brains of patients with Down syndrome and Alzheimer's disease.	ERG BACH1	1.63e-05	2	141	2	15068237
Pubmed	Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of gamma-aminobutyric acid type A receptors.	PLCL2 PLCL1	1.63e-05	2	141	2	19996098
Pubmed	A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme.	PLCH2 PLCD1	1.63e-05	2	141	2	15899900
Pubmed	A Tcf4-GFP reporter mouse model for monitoring effects of Apc mutations during intestinal tumorigenesis.	TCF4 APC	1.63e-05	2	141	2	19263440
Pubmed	Intestinal adenoma formation and MYC activation are regulated by cooperation between MYB and Wnt signaling.	APC MYB	1.63e-05	2	141	2	19609274
Pubmed	Identification and characterization of a new phospholipase C-like protein, PLC-L(2).	PLCL2 PLCL1	1.63e-05	2	141	2	10581172
Pubmed	Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties.	PLCD3 PLCD1	1.63e-05	2	141	2	9056492
Pubmed	PSMD5 Inactivation Promotes 26S Proteasome Assembly during Colorectal Tumor Progression.	APC PSMD5	1.63e-05	2	141	2	29716915
Pubmed	Leptin receptor null mice with reexpression of LepR in GnRHR expressing cells display elevated FSH levels but remain in a prepubertal state.	LEPR FSHB	1.63e-05	2	141	2	27101301
Pubmed	Physiological functions of phospholipase Cδ1 and phospholipase Cδ3.	PLCD3 PLCD1	1.63e-05	2	141	2	23948486
Pubmed	Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions.	LEPR IRS2	1.63e-05	2	141	2	22456697
Pubmed	Promoter methylation of ITF2, but not APC, is associated with microsatellite instability in two populations of colorectal cancer patients.	TCF4 APC	1.63e-05	2	141	2	26884349
Pubmed	N-glycolylneuraminic acid deficiency in mice: implications for human biology and evolution.	DOCK2 CMAHP	1.63e-05	2	141	2	17420276
Pubmed	Diet- and Genetically-Induced Obesity Differentially Affect the Fecal Microbiome and Metabolome in Apc1638N Mice.	APC LEPR	1.63e-05	2	141	2	26284788
Pubmed	Phospholipase C-related inactive protein is involved in trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface.	PLCL2 PLCL1	1.63e-05	2	141	2	17301177
Pubmed	Alopecia in a viable phospholipase C delta 1 and phospholipase C delta 3 double mutant.	PLCD3 PLCD1	1.63e-05	2	141	2	22723964
Pubmed	Involvement of phospholipase C-related inactive protein in the mouse reproductive system through the regulation of gonadotropin levels.	PLCL2 PLCL1	1.63e-05	2	141	2	19553601
Pubmed	Genetic reduction of GABA(A) receptor gamma2 subunit expression potentiates the immobilizing action of isoflurane.	PLCL2 PLCL1	1.63e-05	2	141	2	20097266
Pubmed	Obesity enhances gastrointestinal tumorigenesis in Apc-mutant mice.	APC LEPR	1.63e-05	2	141	2	18725892
Pubmed	Phospholipase C-related inactive protein is implicated in the constitutive internalization of GABAA receptors mediated by clathrin and AP2 adaptor complex.	PLCL2 PLCL1	1.63e-05	2	141	2	17254016
Pubmed	Targeting tetramer-forming GABPβ isoforms impairs self-renewal of hematopoietic and leukemic stem cells.	GABPB2 GABPB1	1.63e-05	2	141	2	22862946
Pubmed	Acetate enables metabolic fitness and cognitive performance during sleep disruption.	ACSS1 LEPR	1.63e-05	2	141	2	39163862
Pubmed	The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family.	DOCK2 DOCK3 DOCK4	1.81e-05	13	141	3	21930703
Pubmed	Survival control of oligodendrocyte progenitor cells requires the transcription factor 4 during olfactory bulb development.	TCF4 APC CSPG4	2.30e-05	14	141	3	33462220
Pubmed	Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.	DOCK2 DOCK3 DOCK4	2.30e-05	14	141	3	12432077
Pubmed	Identification of candidate genes at the corticoseptal boundary during development.	TCF4 ZBTB20 JARID2	2.86e-05	15	141	3	16458080
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CACNA1E MYBBP1A CLASP1 USP9X PAK5 APC SYNGAP1 NCOR2 PLCB1 PLCL1 KDM1A PHLDB2 DNM2 AGAP2	3.96e-05	963	141	14	28671696
Pubmed	Region and Cell Type Distribution of TCF4 in the Postnatal Mouse Brain.	TCF4 APC NEUROD6	4.25e-05	17	141	3	32765228
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	USP34 AHCYL1 EMC1 CLASP1 PSMB2 TYK2 PWP1 ARHGAP1 ADSL PGLS IRS2 TTC13 ASCC3 KDM1A	4.47e-05	974	141	14	28675297
Pubmed	Physiological functions of phospholipase C delta-type.	PLCD3 PLCD1	4.88e-05	3	141	2	18177742
Pubmed	Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.	DPF1 DPF3	4.88e-05	3	141	2	18765789
Pubmed	Phospholipase C-related but catalytically inactive protein modulates pain behavior in a neuropathic pain model in mice.	PLCL2 PLCL1	4.88e-05	3	141	2	23639135
Pubmed	The d4 gene family in the human genome.	DPF1 DPF3	4.88e-05	3	141	2	8812431
Pubmed	The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2.	TYK2 IRS2	4.88e-05	3	141	2	8550573
Pubmed	Myb controls intestinal stem cell genes and self-renewal.	APC MYB	4.88e-05	3	141	2	21997934
Pubmed	Myeloid translocation genes differentially regulate colorectal cancer programs.	APC CBFA2T2	4.88e-05	3	141	2	27270437
Pubmed	Identification of NF-κB and PLCL2 as new susceptibility genes and highlights on a potential role of IRF8 through interferon signature modulation in systemic sclerosis.	IRF8 PLCL2	4.88e-05	3	141	2	25880423
Pubmed	A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.	LEPR IRS2	4.88e-05	3	141	2	24037094
Pubmed	Phospholipase C-related catalytically inactive protein, a novel microtubule-associated protein 1 light chain 3-binding protein, negatively regulates autophagosome formation.	PLCL2 PLCL1	4.88e-05	3	141	2	23399561
Pubmed	c-MYB- and PGC1a-dependent metabolic switch induced by MYBBP1A loss in renal cancer.	MYBBP1A MYB	4.88e-05	3	141	2	31066170
Pubmed	A Leptin-Mediated Neural Mechanism Linking Breathing to Metabolism.	LEPR NALCN	4.88e-05	3	141	2	33176139
Pubmed	Involvement of PRIP, phospholipase C-related, but catalytically inactive protein, in bone formation.	PLCL2 PLCL1	4.88e-05	3	141	2	21757756
Pubmed	Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling.	RPGRIP1L LEPR	4.88e-05	3	141	2	21037323
Pubmed	Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis.	LEPR IRS2	4.88e-05	3	141	2	24567904
Pubmed	Vitamin D Deficiency in Uygurs and Kazaks Is Associated with Polymorphisms in CYP2R1 and DHCR7/NADSYN1 Genes.	NADSYN1 CYP2R1	4.88e-05	3	141	2	26149120
Pubmed	Detection of proteins that bind to the leucine zipper motif of c-Myb.	MYBBP1A MYB	4.88e-05	3	141	2	8302594
Pubmed	CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta.	CLASP1 PHLDB2	4.88e-05	3	141	2	16824950
Pubmed	Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in transactivation by Myb.	MYBBP1A MYB	4.88e-05	3	141	2	9447996
Pubmed	Genetic variants of vitamin D metabolism-related DHCR7/NADSYN1 locus and CYP2R1 gene are associated with clinical features of Parkinson's disease.	NADSYN1 CYP2R1	4.88e-05	3	141	2	32938288
Pubmed	Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development.	PLCD3 PLCD1	4.88e-05	3	141	2	16314520
Pubmed	Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis.	APC MYB	4.88e-05	3	141	2	25934694
Pubmed	Membrane targeting of C2 domains of phospholipase C-delta isoforms.	PLCD3 PLCD1	4.88e-05	3	141	2	11706040
Pubmed	Phospholipase C-related catalytically inactive protein (PRIP) regulates lipolysis in adipose tissue by modulating the phosphorylation of hormone-sensitive lipase.	PLCL2 PLCL1	4.88e-05	3	141	2	24945349
Pubmed	A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis.	DOCK4 CSPG4	4.88e-05	3	141	2	26129894
Pubmed	Phospholipase C-related Catalytically Inactive Protein Is a New Modulator of Thermogenesis Promoted by β-Adrenergic Receptors in Brown Adipocytes.	PLCL2 PLCL1	4.88e-05	3	141	2	26706316
Pubmed	A Small Molecule Inhibitor of the β-Catenin-TCF4 Interaction Suppresses Colorectal Cancer Growth In Vitro and In Vivo.	TCF4 APC	4.88e-05	3	141	2	29033371
Pubmed	Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy.	PLCD3 PLCD1	4.88e-05	3	141	2	24810051
Pubmed	B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase.	DOCK2 CMAHP	4.88e-05	3	141	2	19103880
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	DPF1 USP34 TDRKH ERF BCKDHA ADCY9 TYK2 NCOR2 DPF3 PCSK6 LRRC8B IRS2 ASCC3 KDM1A PHLDB2	5.06e-05	1116	141	15	31753913
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	CACNA1E CLASP1 USP9X APC BTBD17 BCKDHA ARMCX1 DECR2 AGAP2	6.90e-05	430	141	9	32581705
Pubmed	Silencing mediator for retinoid and thyroid hormone receptor and nuclear receptor corepressor attenuate transcriptional activation by the beta-catenin-TCF4 complex.	TCF4 NCOR2	9.74e-05	4	141	2	18632669
Pubmed	miR-135a targets IRS2 and regulates insulin signaling and glucose uptake in the diabetic gastrocnemius skeletal muscle.	LEPR IRS2	9.74e-05	4	141	2	23579070
Pubmed	A mutation in the Icsbp1 gene causes susceptibility to infection and a chronic myeloid leukemia-like syndrome in BXH-2 mice.	IRF8 SYNGAP1	9.74e-05	4	141	2	15781580
Pubmed	Ultrafine mapping of SNPs from mouse strains C57BL/6J, DBA/2J, and C57BLKS/J for loci contributing to diabetes and atherosclerosis susceptibility.	DOCK4 LEPR	9.74e-05	4	141	2	15793261
Pubmed	Loss of protein-tyrosine phosphatase α (PTPα) increases proliferation and delays maturation of oligodendrocyte progenitor cells.	APC CSPG4	9.74e-05	4	141	2	22354965
Pubmed	Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice.	LEPR IRS2	9.74e-05	4	141	2	15685168
Pubmed	Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice.	RPGRIP1L LEPR	9.74e-05	4	141	2	24807221
Pubmed	Hypomorphism of Fto and Rpgrip1l causes obesity in mice.	RPGRIP1L LEPR	9.74e-05	4	141	2	27064284
Pubmed	Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs.	PLCB1 PLCD1	9.74e-05	4	141	2	9188725
Pubmed	APC inhibits ERK pathway activation and cellular proliferation induced by RAS.	TCF4 APC	9.74e-05	4	141	2	16478791
Pubmed	Foxo1 integrates insulin signaling with mitochondrial function in the liver.	LEPR IRS2	9.74e-05	4	141	2	19838201
Pubmed	Intestinal-specific activatable Myb initiates colon tumorigenesis in mice.	APC MYB	9.74e-05	4	141	2	26300002
Pubmed	IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line.	USP9X IRS2	9.74e-05	4	141	2	30338032
Pubmed	KLF4 interacts with beta-catenin/TCF4 and blocks p300/CBP recruitment by beta-catenin.	TCF4 APC	9.74e-05	4	141	2	19901072
Pubmed	Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse.	LEPR IRS2	9.74e-05	4	141	2	9399964
Pubmed	Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.	LEPR IRS2	9.74e-05	4	141	2	21700708
Pubmed	Phospholipase C-related, but catalytically inactive protein (PRIP) up-regulates osteoclast differentiation via calcium-calcineurin-NFATc1 signaling.	PLCL2 PLCL1	9.74e-05	4	141	2	28341745
Pubmed	IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action.	LEPR IRS2	9.74e-05	4	141	2	22560222
Pubmed	SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.	ERF ERG	9.74e-05	4	141	2	26344095
Pubmed	Molecular cloning and characterization of a novel phospholipase C, PLC-eta.	PLCB1 PLCD1	9.74e-05	4	141	2	15702972
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	USP34 AHCYL1 MYBBP1A USP9X PSMB2 THUMPD3 LARS1 OGDH PWP1 ADSL	1.19e-04	571	141	10	37167062
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	MYBBP1A EMC1 USP9X TTI2 PSMB2 LARS1 TMEM214 PCSK6 B3GNT2 TTC13 ASCC3 ZNHIT2 GAA	1.27e-04	942	141	13	31073040
Pubmed	Rheb1 is required for mTORC1 and myelination in postnatal brain development.	APC CSPG4 IRS2	1.41e-04	25	141	3	21238928
Pubmed	Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways.	APC LEPR IRS2	1.41e-04	25	141	3	18992263
Interaction	FBXO2 interactions	SEMA3C EMC1 MANBA LRP1B LEPR SYNGAP1 TENM3 B3GNT2 CSPG4 TTC13 SCARA3 GAA B4GALT3	4.74e-06	411	137	13	int:FBXO2
Cytoband	3q13.2	ZBTB20 TMPRSS7 PHLDB2	1.20e-04	31	141	3	3q13.2
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLCD3 PLCL2 PLCB1 PLCD1 PLCL1	5.12e-08	19	100	5	832
GeneFamily	Phospholipases	PLCD3 PLCH2 PLCB1 PLCD1	8.39e-05	42	100	4	467
Coexpression	DING_LUNG_CANCER_BY_MUTATION_RATE	LRP1B TYK2 PIK3C2G MYB	3.34e-06	20	138	4	M1189
Coexpression	GSE15930_NAIVE_VS_48H_IN_VITRO_STIM_CD8_TCELL_UP	SEMA4F ZBTB20 DAO JARID2 PCSK6 IRS2 PLCD1 NEUROD6	1.06e-05	198	138	8	M3596
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW13-Neuronal-Cortical_neuron\|GW13 / Sample Type, Dataset, Time_group, and Cell type.	SEMA3C MYBBP1A TOX PAK5 ARMCX1	7.03e-08	34	140	5	6c9c477b43009cded5a2e1a1792c32c40d9309a8
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l34\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1E ERG ITGA10 CSPG4 PLCB1 B4GALNT3 TMPRSS7 SCARA3	8.99e-08	176	140	8	77c3da2eaa072a6baefb5087fd07ec18c5e271cd
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	AKAP6 DOCK3 DPF3 PLCL2 PLCL1 B4GALNT3 CFAP61 FYB2	1.43e-07	187	140	8	78cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|RV / Chamber and Cluster_Paper	AKAP6 DOCK3 DPF3 PLCL2 PLCL1 B4GALNT3 CFAP61 FYB2	1.56e-07	189	140	8	9c1debd65c13d63fd4f3158917d621b44b714c26
ToppCell	COVID-19-Heart-CM_1\|Heart / Disease (COVID-19 only), tissue and cell type	AKAP6 DOCK3 NALCN DPF3 PLCL1 B4GALNT3 CFAP61 FYB2	1.98e-07	195	140	8	f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HYAL4 CA12 SEMA3C TOX PIK3C2G PLCL2 FYB2	7.94e-07	161	140	7	176a4a72bb4892932da3c834d1fea5e211847f92
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E TCF4 ZBTB20 IRF8 DAO PLCD3 CMAHP	1.34e-06	174	140	7	28ec25767bbd4fd898738f9f4d2b585dc91b5adf
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L5-6_RORB_LINC00320\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TOX COBLL1 LRP1B B4GALNT3 NEUROD6 SCARA3 PHLDB2	1.50e-06	177	140	7	01df8ab3285fa66b4805c555cfbfc4b3b16db919
ToppCell	droplet-Marrow-nan-3m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E TCF4 TEX2 IRF8 APC CMAHP FYB2	1.61e-06	179	140	7	dcaf2191134a586d50ebaf67dcf5b815b54a722b
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E TCF4 TEX2 IRF8 APC CMAHP FYB2	1.61e-06	179	140	7	87a69f9f83b8f0c028a4874acb238f2e079bf51f
ToppCell	LV\|World / Chamber and Cluster_Paper	AKAP6 DPF3 PLCL2 PLCL1 B4GALNT3 CFAP61 FYB2	1.67e-06	180	140	7	5ac6f485a58bb29462fec02dfbe8eb70864eafe3
ToppCell	facs-Marrow-B-cells-3m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E TCF4 TEX2 IRF8 APC CMAHP FYB2	1.67e-06	180	140	7	bf8d13d4db1af55b8c9fe16aaccf8743e000e005
ToppCell	facs-Marrow-B-cells-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E TCF4 TEX2 IRF8 APC CMAHP FYB2	1.67e-06	180	140	7	839defb40f7cfb2711e9025194de636533f51bcd
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E TCF4 TEX2 IRF8 APC CMAHP FYB2	1.67e-06	180	140	7	df60970520fba2ac0639faa54096766d07418ca4
ToppCell	facs-Marrow-B-cells-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E TCF4 TEX2 IRF8 APC CMAHP FYB2	1.67e-06	180	140	7	82965ed1b72a1873c24dd4553d39681596057316
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 TOX ADCY9 NDST3 PIK3C2G PLCL2 FYB2	1.74e-06	181	140	7	aa233b652921848af2257cc3687a7a09c3acfb67
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CA12 CAPN6 ITGA10 TENM3 CSPG4 PLCB1 SCARA3	2.01e-06	185	140	7	8ed10ba581849c9c4ac4397226be2b62b4b3b900
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CA12 CAPN6 ITGA10 TENM3 CSPG4 PLCB1 SCARA3	2.01e-06	185	140	7	b8052cebb73f41abe6faf0aa847be7c8ef23ae94
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	AKAP6 DPF3 PLCL2 PLCL1 B4GALNT3 CFAP61 FYB2	2.24e-06	188	140	7	0758b474457efa36488e0195f7357100f4b6a090
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HYAL4 TOX COBLL1 M1AP PIK3C2G PLCL2 FYB2	2.24e-06	188	140	7	58ccb31cdf43167872ef0fc737e6f9c51ee2e060
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	AKAP6 DPF3 PLCL2 PLCL1 B4GALNT3 CFAP61 FYB2	2.32e-06	189	140	7	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	AKAP6 DPF3 PLCL2 PLCL1 B4GALNT3 CFAP61 FYB2	2.40e-06	190	140	7	de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 SEMA3C TOX COBLL1 PIK3C2G B4GALNT3 FYB2	2.40e-06	190	140	7	b3bccf4dd95e986db3cee324a6737f5fcc22e8e5
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK3 ZNF704 SEMA3C NALCN PLCL1 SCARA3 TNXB	2.48e-06	191	140	7	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CA12 ERG CAPN6 ITGA10 TENM3 CSPG4 B4GALNT3	2.48e-06	191	140	7	273c4a757292a9301de0eaeacdec91c9866be229
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CA12 ERG CAPN6 ITGA10 TENM3 CSPG4 B4GALNT3	2.48e-06	191	140	7	f9a46956778a8773d6656340ecf5d218376d79c2
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|LV / Chamber and Cluster_Paper	AKAP6 DOCK3 DPF3 PLCL2 PLCL1 B4GALNT3 FYB2	2.57e-06	192	140	7	ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell	343B-Lymphocytic-ILC-ILC-1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ERF HGSNAT NADSYN1 DPP9 CYP2R1 B3GNT2 LRRC8B	2.57e-06	192	140	7	445985fe1bcd33e4f0a1704b27988fbfc9334538
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	TCF4 MANBA MYO9B COBLL1 BACH1 IRF8 CYP2R1	2.66e-06	193	140	7	08696a99309f5b088692ddac8cca35413b5e810d
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	AKAP6 DOCK3 DPF3 PLCL1 B4GALNT3 CFAP61 FYB2	2.85e-06	195	140	7	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 AHCYL1 CLASP1 COBLL1 PIK3C2G MED12L PLCL1	2.85e-06	195	140	7	a38d9dc6192aea673d96fda6b25e81223fda3abf
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-FILIP1L\|Neuronal / cells hierarchy compared to all cells using T-Statistic	COBLL1 DPF3 PLCH2 MED12L PLCL1 CMAHP PHLDB2	3.37e-06	200	140	7	f6af5ef02625aaae21e885e1ebd195e34731e53a
ToppCell	Neuronal-Excitatory-eC(RORB)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	TOX COBLL1 DPF3 CMAHP NEUROD6 SCARA3 PHLDB2	3.37e-06	200	140	7	8c803a0ce25e140b46036f6aabefc5502601f408
ToppCell	LPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	KIF27 DNAH1 TMEM232 PIK3C2G B4GALNT3 FYB2 MYB	3.37e-06	200	140	7	96701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-FILIP1L-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	COBLL1 DPF3 PLCH2 MED12L PLCL1 CMAHP PHLDB2	3.37e-06	200	140	7	53f61e28c3ad6399f63c54e06120ecb5ebbf90d9
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-FILIP1L--L3-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	COBLL1 DPF3 PLCH2 MED12L PLCL1 CMAHP PHLDB2	3.37e-06	200	140	7	c1f243ae929f7791e040437470033abf749b44cc
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	TOX COBLL1 LRP1B B4GALNT3 NEUROD6 SCARA3 PHLDB2	3.37e-06	200	140	7	6b0235cfbdb70068c43ac71301f4a7b41854929e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 COBLL1 LRP1B PIK3C2G B4GALNT3 FYB2	9.04e-06	153	140	6	9b6675ace8a83c8d446b722301d0ec4e6840f3fc
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 COBLL1 PAK5 PIK3C2G B4GALNT3 FYB2	1.39e-05	165	140	6	9bd332e5ede759a00a47728ea5558c215efdd77a
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4-5_RORB_AIM2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERG TOX TRB CMAHP NEUROD6 PHLDB2	1.49e-05	167	140	6	4c8bb68ee2bf7b794940b34df96f38f3f69507e9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 SEMA3C COBLL1 PIK3C2G B4GALNT3 FYB2	1.49e-05	167	140	6	edc5f04584b44f99ff9a62bbe0dab6fc044fb334
ToppCell	droplet-Lung-LUNG-30m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E TCF4 TEX2 IRF8 CMAHP FYB2	1.54e-05	168	140	6	e156297a7515e785a9e79a9676700bd3a9d92b98
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E TCF4 TEX2 IRF8 CMAHP FYB2	1.54e-05	168	140	6	32e0bc0873baa13027241063283ef26d2aab56f5
ToppCell	Adult-Mesenchymal-chondrocyte-D175\|Adult / Lineage, Cell type, age group and donor	LARS1 PWP1 PLCD3 PIK3C2G SCARA3 TNXB	1.54e-05	168	140	6	14071b961c9bdb54a8259b12a88237b802cbde36
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 COBLL1 LRP1B ZNF365 PIK3C2G B4GALNT3	1.59e-05	169	140	6	0332f539a2f7d6dcd081a5d2f567290721f5a329
ToppCell	facs-Trachea-18m-Hematologic-myeloid-granulocyte-granulocyte_l26\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOCK2 TDRKH COBLL1 PLCL1 FYB2 MYB	1.64e-05	170	140	6	4b1c84b35b7242a297ffdb9c23a6d982acf1bed5
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L5_RORB_LINC01202\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TOX COBLL1 CMAHP NEUROD6 SCARA3 PHLDB2	1.76e-05	172	140	6	18bdf34e1b94dcb1daf00c533e3ce1a8d67fcc0e
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TOX COBLL1 CMAHP NEUROD6 SCARA3 PHLDB2	1.76e-05	172	140	6	41ddfb316429efef5f3fa0b0621ced383d9206f0
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4-5_RORB_ASCL1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERG TRB JARID2 CMAHP NEUROD6 PHLDB2	1.82e-05	173	140	6	2e35bf2b5534a289d93a09faae660f665c131062
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_SEMA6D\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COBLL1 PLCH2 MED12L PLCL1 CMAHP PHLDB2	1.82e-05	173	140	6	9a2d42f8d9cb834856522661d524abb91c4637c5
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_LINC01474\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TOX TRB COBLL1 DPF3 CMAHP NEUROD6	1.94e-05	175	140	6	030f93af5a96848b9118e2a8116e19ddae438d92
ToppCell	facs-Marrow-T_cells-18m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E TCF4 TEX2 IRF8 MED12L FYB2	2.00e-05	176	140	6	74f851a398c7562dd713bc0d8d488c0037243112
ToppCell	facs-Marrow-T_cells-18m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E TCF4 TEX2 IRF8 MED12L FYB2	2.00e-05	176	140	6	31b5459a978d5cdde0af03a77401e0464d8c95ba
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HYAL4 CA12 SEMA3C PAK5 PIK3C2G FYB2	2.07e-05	177	140	6	8e4005fad50e6f919da175f3b9ae58849dbd60b1
ToppCell	B_cell_maturation-CD34+_pre-plamsa\|World / Lineage and Cell class	TCF4 ERG ZNF22-AS1 QRSL1 GABPB1 MYB	2.07e-05	177	140	6	3ff06100deee9bee852a52078666999a9f7beaf1
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_LINC01474\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TOX COBLL1 DPF3 CMAHP NEUROD6 SCARA3	2.13e-05	178	140	6	f7f88879a05b2b5fa92cf5317b76f7a3064d1358
ToppCell	facs-Lung-nan-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CA12 ZNF704 COBLL1 LEPR CSPG4 PLCL1	2.20e-05	179	140	6	7078022e60faa86444f2a2c6eb9f767cc66b5cfa
ToppCell	facs-Lung-nan-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CA12 ZNF704 COBLL1 LEPR CSPG4 PLCL1	2.20e-05	179	140	6	d4a975d8ffa5e77fb5c0ec05bf9c8f843c77ce07
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TOX COBLL1 PIK3C2G PLCL2 B4GALNT3 FYB2	2.27e-05	180	140	6	023ec0b080c8a5cd0f36e83c6b17d4be3c01edb5
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TOX COBLL1 ZNF365 PIK3C2G B4GALNT3 FYB2	2.27e-05	180	140	6	788d5fbf688365b5d92d3aa19b9f8e9448f8be5a
ToppCell	RV\|World / Chamber and Cluster_Paper	AKAP6 DPF3 PLCL2 PLCL1 CFAP61 FYB2	2.34e-05	181	140	6	bbe1e6e59d8889bd37d6e8303116cbdcafca7236
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TOX COBLL1 M1AP PIK3C2G PLCL2 FYB2	2.34e-05	181	140	6	b7c85fbef3c06d5dc32a2a58f8d3dfabf1d79d9f
ToppCell	COVID-19-Heart-EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TCF4 ERG CSPG4 PLCB1 PLCL1 AGAP2	2.42e-05	182	140	6	e67f3234165199085c793915ebb1f9bbd845e933
ToppCell	COVID-19-kidney-CD-IC-B\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CA12 SEMA3C COBLL1 PLCL1 FYB2 PHLDB2	2.42e-05	182	140	6	ee6a8c356bbbdae55e4ea858337e079491f9f4aa
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AKAP6 SEMA4F CAPN6 ITGA10 TENM3 CSPG4	2.42e-05	182	140	6	a1c0e4090a9e7aa4941a40c817d178de144888b6
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 COBLL1 ACSS1 LRP1B PLCB1 PLCL1	2.49e-05	183	140	6	31ab55d5f3639f5964541d5eae23044dbda3356e
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK3 ZNF704 SEMA3C NALCN SCARA3 TNXB	2.49e-05	183	140	6	7eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCell	COVID-19-kidney-CD-IC-A\|kidney / Disease (COVID-19 only), tissue and cell type	CA12 SEMA3C COBLL1 PAK5 PLCL1 FYB2	2.49e-05	183	140	6	5c7597a5b2bf6a481ca2c7e68560179214150fa0
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNF704 SEMA3C NDST3 NALCN SCARA3 TNXB	2.49e-05	183	140	6	12daaea821e49bc94a01e2496331e92a80d27339
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 ZNF704 CLASP1 COBLL1 PIK3C2G B4GALNT3	2.49e-05	183	140	6	2e831a4d99c6f983793df71c0994124c943c6da9
ToppCell	PBMC-Severe-Hematopoietic-HSPC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DPF1 ZNF704 ERG ARMCX1 MED12L MYB	2.57e-05	184	140	6	a6169613c6493b947a176493f542368bfa935dab
ToppCell	PBMC-Severe-Hematopoietic-HSPC-HSPC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DPF1 ZNF704 ERG ARMCX1 MED12L MYB	2.57e-05	184	140	6	51d0447699e3b8f01abbde83f26b748bc9f3c723
ToppCell	PBMC-Severe-Hematopoietic-HSPC-HSPC-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DPF1 ZNF704 ERG ARMCX1 MED12L MYB	2.57e-05	184	140	6	f7b0bb45a9055ab34e98b251217f6ec38c75ca22
ToppCell	PBMC-Severe-Hematopoietic-HSPC-HSPC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DPF1 ZNF704 ERG ARMCX1 MED12L MYB	2.57e-05	184	140	6	cc01c19180861f491a8dc16d60fabd1215fc4525
ToppCell	COVID-19-Heart-CM_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AKAP6 DOCK3 NALCN DPF3 CFAP61 FYB2	2.57e-05	184	140	6	e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCell	PBMC-Severe-Hematopoietic-HSPC-HSPC-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DPF1 ZNF704 ERG ARMCX1 MED12L MYB	2.57e-05	184	140	6	492c680f0769ba4e651d09c2e8e5d5d271ed08aa
ToppCell	PBMC-Severe-Hematopoietic-HSPC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	DPF1 ZNF704 ERG ARMCX1 MED12L MYB	2.57e-05	184	140	6	26edbf84216538b80f1ffcc079ee6e385a71fbf9
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK3 ZNF704 SEMA3C NALCN SCARA3 TNXB	2.65e-05	185	140	6	6712512100ccef456d2e2bd201d0987986c92ac9
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK3 SEMA3C NALCN PLCB1 SCARA3 TNXB	2.65e-05	185	140	6	3b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 COBLL1 ACSS1 LRP1B PLCB1 PLCL1	2.65e-05	185	140	6	898a093757f86be3e18d2ef1f16a71f50ef81dc3
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AKAP6 DOCK3 ZNF704 SEMA3C NALCN SCARA3	2.73e-05	186	140	6	6add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCell	facs-Heart-LA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBR1 COBLL1 B3GNT2 CSPG4 PLCL1 AGAP2	2.73e-05	186	140	6	e2ba9f3518d87a44537a57a648df17ab98fbbb39
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 COBLL1 LRP1B PIK3C2G B4GALNT3 FYB2	2.73e-05	186	140	6	d65fa6d8e8a195ea10cfde1499d096d6acf7a634
ToppCell	facs-Heart-LA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBR1 COBLL1 B3GNT2 CSPG4 PLCL1 AGAP2	2.73e-05	186	140	6	fda3415222f688ef5cd8de4b0b79daa2493c585f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 COBLL1 LRP1B PIK3C2G B4GALNT3 FYB2	2.73e-05	186	140	6	08632045d499e61dd96ff29a5a9a208afe58dc58
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 ZNF704 COBLL1 PIK3C2G B4GALNT3 FYB2	2.73e-05	186	140	6	b3358e0fa6d845c81e94d56c8575f016621d28ff
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 COBLL1 LRP1B PLCB1 PLCD1 B4GALNT3	2.81e-05	187	140	6	77886f99c229610abd28c4c370d2c7d1536c9782
ToppCell	Healthy-HSPC\|World / disease group, cell group and cell class	DPF1 ZNF704 ERG MED12L TTLL10 MYB	2.81e-05	187	140	6	8cd9e5499e5c2b2321ecbcf780df37fe0f165ac9
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK3 ZNF704 SEMA3C TOX NALCN SCARA3	2.90e-05	188	140	6	3177b2c1723268d330d3e9f24f9e24492ace6286
ToppCell	343B-Lymphocytic-ILC-ILC-1\|343B / Donor, Lineage, Cell class and subclass (all cells)	ERF NADSYN1 DPP9 CYP2R1 B3GNT2 LRRC8B	2.90e-05	188	140	6	8f6b45ad82bde65e044d17f0edbc3db90d457915
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 CLASP1 COBLL1 PIK3C2G MED12L B4GALNT3	2.90e-05	188	140	6	bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 DOCK3 COBLL1 LRP1B PLCB1 PLCL1	2.90e-05	188	140	6	2ee64bc73a2251fd9f374be759b442cf4ed0d19e
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AKAP6 DOCK3 ZNF704 SEMA3C NALCN SCARA3	2.90e-05	188	140	6	293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 SEMA3C COBLL1 PLCL1 B4GALNT3 FYB2	2.90e-05	188	140	6	e751cff2ac8fbc1487766c1871fcc5d1005286b0
ToppCell	COVID-19-kidney-CD-PC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CA12 TOX COBLL1 LRP1B PIK3C2G FYB2	2.90e-05	188	140	6	8f9996c3f3b27efaaae8960a66af77412de9c7ef
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 TOX COBLL1 LRP1B PIK3C2G B4GALNT3	2.90e-05	188	140	6	4154f4787483c7e076e87a187733a9f666742c3d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 DOCK3 COBLL1 LRP1B PLCB1 PLCL1	2.99e-05	189	140	6	f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF704 TOX COBLL1 PIK3C2G B4GALNT3 FYB2	2.99e-05	189	140	6	8ff3c3232eff9de4b5c9b22ecb82bc509d773f58
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 CLASP1 COBLL1 PIK3C2G MED12L PLCL1	2.99e-05	189	140	6	977a813e5d7a5a561c1fced2bbf21c20056b88d8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 TOX COBLL1 PIK3C2G B4GALNT3 FYB2	2.99e-05	189	140	6	a9864873b19ab3e60acf11f288fa7275badc2e42
Drug	ADP beta S	CACNA1E APC ADCY9 ADSL P2RY4 PLCB1 PLCD1	2.06e-06	96	139	7	CID005310996
Drug	Cefotetan [69712-56-7]; Up 200; 7uM; PC3; HT_HG-U133A	AKAP6 ZBTB20 TOX IRF8 DPF3 PLCH2 CBFA2T2 PLCB1 MYB	3.67e-06	198	139	9	3997_UP
Drug	Tocainide hydrochloride; Up 200; 17.4uM; PC3; HT_HG-U133A	TDRKH ZBTB20 NEB F12 NCOR2 DPF3 FSHB MYB AGAP2	3.82e-06	199	139	9	4256_UP
Drug	myo-inositol	CACNA1E TCF4 TEX2 ADCY9 PLCD3 ARHGAP1 P2RY4 PIK3C2G BRS3 FSHB PLCB1 IRS2 PLCD1 PLCL1 GAA DNM2 AGAP2	9.52e-06	811	139	17	CID000000892
Drug	Phenacetin [62-44-2]; Up 200; 22.4uM; MCF7; HT_HG-U133A	USP34 TDRKH MANBA LEPR PCSK6 PLCB1 IRS2 PLCD1	2.17e-05	189	139	8	2832_UP
Drug	troglitazone; Down 200; 10uM; PC3; HG-U133A	BACH1 PAQR4 HGSNAT BCKDHA GPR107 PLCB1 DECR2 PLCD1	2.52e-05	193	139	8	462_DN
Drug	1-phenyl-1,2-propanedione	OGDH CES2 P2RY4	2.59e-05	10	139	3	CID000011363
Drug	Scoulerine [6451-73-6]; Down 200; 12.2uM; PC3; HT_HG-U133A	TCF4 MANBA ITGA10 BCKDHA ARHGAP1 LRRC8B GABPB1 MYB	2.81e-05	196	139	8	5111_DN
Drug	Famotidine [76824-35-6]; Up 200; 11.8uM; MCF7; HT_HG-U133A	MYO9B NEB LEPR NCOR2 P2RY4 DPF3 PCSK6 PLCB1	2.81e-05	196	139	8	5011_UP
Drug	Convolamine hydrochloride [500-56-1]; Up 200; 11.8uM; HL60; HG-U133A	CA12 DOCK4 MYO9B APC OGDH GPR107 ARHGAP1 PCSK6	2.92e-05	197	139	8	1779_UP
Drug	Esculetin [305-01-1]; Up 200; 22.4uM; MCF7; HT_HG-U133A	USP34 SEMA4F LEPR NCOR2 CYP2R1 PCSK6 IRS2 PLCD1	2.92e-05	197	139	8	7459_UP
Drug	Fluocinonide [356-12-7]; Down 200; 8uM; MCF7; HT_HG-U133A	EMC1 MANBA MYO9B COBLL1 PCSK6 PLCB1 LRRC8B PLCD1	2.92e-05	197	139	8	3933_DN
Drug	Verapamyl hydrochloride [152-11-4]; Up 200; 8.2uM; MCF7; HT_HG-U133A	SEMA4F TOX COBLL1 LEPR ADCY9 CBFA2T2 PLCL2 PLCD1	3.02e-05	198	139	8	5387_UP
Drug	Benzydamine hydrochloride [132-69-4]; Up 200; 11.6uM; HL60; HG-U133A	ERF BACH1 ITGA10 CES2 DPF3 CBFA2T2 DECR2 PLCD1	3.13e-05	199	139	8	1552_UP
Drug	2-chloroadenosine	AHCYL1 APC ADCY9 PLCB1 PLCD1 SLC29A4	3.87e-05	102	139	6	CID000008974
Disease	testosterone measurement	DOCK3 DOCK4 ZNF704 UBR1 ZBTB20 KIF27 MANBA SLC27A6 MYO9B COBLL1 PSMB2 DAO LEPR ADCY9 TYK2 NCOR2 B3GNT2 PLCB1	1.95e-05	1275	134	18	EFO_0004908
Disease	developmental disorder of mental health (implicated_via_orthology)	TCF4 SYNGAP1 NCOR2 NCKAP1L	7.35e-05	49	134	4	DOID:0060037 (implicated_via_orthology)
Disease	age at menarche	USP34 TCF4 ZBTB20 LRP1B LEPR GABPB2 PLCB1 PLCL1 CFAP61 ASCC3 GABPB1	8.85e-05	594	134	11	EFO_0004703
Disease	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	TRB TYK2 DNM2 MYB	1.00e-04	53	134	4	C1961099
Disease	monocyte count	TCF4 ERF ERG CLASP1 IRF8 OGDH LEPR ADCY9 NCOR2 ADSL PLCL2 MED12L PLCB1 LRRC8B IRS2 CMAHP MYB	1.04e-04	1320	134	17	EFO_0005091
Disease	mean corpuscular hemoglobin concentration	SEMA3C ERG CLASP1 MYO9B COBLL1 NEB LEPR ADCY9 B3GNT2 PLCL2 PLCB1 IRS2 CMAHP GAA MYB	1.55e-04	1105	134	15	EFO_0004528
Disease	schizophrenia, intelligence, self reported educational attainment	AKAP6 TCF4 VPS45 LRP1B ZNF365 PLCL2 PLCL1 CMAHP	1.91e-04	346	134	8	EFO_0004337, EFO_0004784, MONDO_0005090
Disease	Schizophrenia	DOCK4 TCF4 MYO9B APC DAO SYNGAP1 NDST3 ARHGAP1 JARID2 B3GNT2 PLCL2 PLCB1 TNXB	2.00e-04	883	134	13	C0036341
Disease	mood instability measurement	TCF4 LRP1B TMEM232 PLCL2 PLCL1	3.03e-04	128	134	5	EFO_0008475
Disease	myelofibrosis (implicated_via_orthology)	NCOR2 MYB	3.03e-04	6	134	2	DOID:4971 (implicated_via_orthology)
Disease	respiratory failure, COVID-19	TYK2 DPP9 CFAP61	3.07e-04	29	134	3	EFO_0009686, MONDO_0100096
Disease	primary biliary cirrhosis	MANBA IRF8 TYK2 NADSYN1 PLCL2	3.62e-04	133	134	5	EFO_1001486
Disease	longitudinal BMI measurement	DOCK4 CACNA1E LEPR PIK3C2G	5.41e-04	82	134	4	EFO_0005937
Disease	vitamin D measurement, vitamin D dietary intake measurement	NADSYN1 CYP2R1	5.63e-04	8	134	2	EFO_0004631, EFO_0008539
Disease	serum iron measurement	ERG LRP1B LEPR CMAHP	6.47e-04	86	134	4	EFO_0006332
Disease	interferon alpha/beta receptor 1 measurement	TYK2 CRYZL1	7.22e-04	9	134	2	EFO_0021850
Disease	response to glucocorticoid, osteonecrosis	ZNF704 SEMA3C BACH1	7.43e-04	39	134	3	EFO_0004259, GO_0051384
Disease	Paroxysmal atrial fibrillation	AKAP6 USP34 SLC27A6 DPF3 PHLDB2	7.48e-04	156	134	5	C0235480
Disease	familial atrial fibrillation	AKAP6 USP34 SLC27A6 DPF3 PHLDB2	7.48e-04	156	134	5	C3468561
Disease	Persistent atrial fibrillation	AKAP6 USP34 SLC27A6 DPF3 PHLDB2	7.48e-04	156	134	5	C2585653
Disease	Atrial Fibrillation	AKAP6 USP34 SLC27A6 DPF3 PHLDB2	8.38e-04	160	134	5	C0004238
Disease	cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement	KIF27 COBLL1 CES2 DNAH1 NCOR2 PCSK6	8.75e-04	243	134	6	EFO_0004612, EFO_0020944
Disease	lymphocyte percentage of leukocytes	ERG MANBA IRF8 LEPR ADCY9 TYK2 PLCL2 PLCB1 CFAP61 MYB	9.44e-04	665	134	10	EFO_0007993
Disease	Intellectual Disability	AKAP6 CACNA1E TTI2 APC SYNGAP1 ADSL MED12L ASCC3	1.03e-03	447	134	8	C3714756
Disease	vascular endothelial growth factor D measurement	F12 PCSK6	1.10e-03	11	134	2	EFO_0010575
Disease	Paranoia	TCF4 TYK2	1.10e-03	11	134	2	C1456784
Disease	neuroticism measurement, cognitive function measurement	CACNA1E KIF27 APC LRP1B SYNGAP1 TENM3 PLCL2 PLCL1 ASCC3	1.16e-03	566	134	9	EFO_0007660, EFO_0008354
Disease	platelet-to-lymphocyte ratio	ERG MANBA TYK2 MED12L IRS2 CMAHP MYB	1.39e-03	363	134	7	EFO_0008446
Disease	vitamin D measurement, COVID-19	NADSYN1 DPP9 CYP2R1	1.45e-03	49	134	3	EFO_0004631, MONDO_0100096
Disease	breast cancer (biomarker_via_orthology)	ADSL KDM1A	1.55e-03	13	134	2	DOID:1612 (biomarker_via_orthology)
Disease	transmembrane protein 87B measurement	F12 PCSK6	1.55e-03	13	134	2	EFO_0802158
Disease	gallbladder cancer (is_implicated_in)	APC LRP1B	1.55e-03	13	134	2	DOID:3121 (is_implicated_in)
Disease	treatment-resistant hypertension	DOCK3 TCF4 SEMA3C ERG	1.57e-03	109	134	4	EFO_1002006
Disease	atrial fibrillation	AKAP6 USP34 MANBA SLC27A6 NCOR2 DPF3 PHLDB2	1.57e-03	371	134	7	EFO_0000275
Disease	glucose measurement	ZBTB20 COBLL1 OGDH ADCY9 SYNGAP1 ARHGAP1 PIK3C2G	1.80e-03	380	134	7	EFO_0004468
Disease	R-6-hydroxywarfarin measurement	ZNF704 ERG LRP1B NCOR2	1.84e-03	114	134	4	EFO_0803327
Disease	health study participation	TCF4 LRP1B PLCD3 PLCL1 ASCC3	2.01e-03	195	134	5	EFO_0010130
Disease	sex interaction measurement, inflammatory bowel disease	ZNF365 CMAHP TNXB	2.02e-03	55	134	3	EFO_0003767, EFO_0008343
Disease	Hypogonadotropic hypogonadism	LEPR FSHB	2.07e-03	15	134	2	C0271623
Disease	Primary hypogonadism	LEPR FSHB	2.07e-03	15	134	2	C0948896
Disease	Hypogonadism, Isolated Hypogonadotropic	LEPR FSHB	2.07e-03	15	134	2	C3489396
Disease	attention deficit hyperactivity disorder, autism spectrum disorder, intelligence	AKAP6 RPGRIP1L MANBA OGDH DPF3 PLCL2 PLCL1	2.34e-03	398	134	7	EFO_0003756, EFO_0003888, EFO_0004337
Disease	ureidopropionic acid measurement	ZNF704 RPGRIP1L	2.36e-03	16	134	2	EFO_0010542
Disease	Hypogonadism	LEPR FSHB	2.36e-03	16	134	2	C0020619
Disease	creatine kinase measurement	AKAP6 BACH1 NEB	2.47e-03	59	134	3	EFO_0004534
Disease	PROSTATE CANCER, HEREDITARY, 1	DOCK2 TCF4 MYO9B	2.59e-03	60	134	3	C4722327
Disease	response to radiation, Urinary retention	LRP1B DNM2	2.66e-03	17	134	2	GO_0009314, HP_0000016
Disease	Lipidemias	APC LEPR	2.66e-03	17	134	2	C1706412
Disease	sex interaction measurement, ulcerative colitis	ZNF365 TNXB	2.66e-03	17	134	2	EFO_0000729, EFO_0008343
Disease	Hyperlipidemia	APC LEPR	2.66e-03	17	134	2	C0020473
Disease	RS-warfarin measurement	CA12 SLC27A6 LRP1B FYB2	2.81e-03	128	134	4	EFO_0803325
Disease	verbal-numerical reasoning measurement	AKAP6 DOCK2 CACNA1E PLCL2	3.05e-03	131	134	4	EFO_0008394
Disease	obesity (implicated_via_orthology)	TCF4 LEPR TYK2 MED12L PLCB1	3.06e-03	215	134	5	DOID:9970 (implicated_via_orthology)
Disease	rheumatoid arthritis, COVID-19	FRYL TYK2 TNXB	3.12e-03	64	134	3	EFO_0000685, MONDO_0100096
Disease	dense area measurement, mammographic density measurement	ZNF365 ADSL	3.33e-03	19	134	2	EFO_0005941, EFO_0006503
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	AKAP6 TCF4 TDRKH AHCYL1 ZBTB20 TOX PLCL2 DLX6 ASCC3 NEUROD6	3.66e-03	801	134	10	EFO_0003888, EFO_0007052, MONDO_0002491
Disease	COVID-19, osteoarthritis	TYK2 DPP9	3.69e-03	20	134	2	MONDO_0005178, MONDO_0100096
Disease	smoking cessation	CACNA1E ZBTB20 RPGRIP1L OGDH LEPR PLCL2	3.77e-03	325	134	6	EFO_0004319
Disease	HbA1c measurement	CLASP1 MYO9B COBLL1 ADCY9 CYP2R1 ZNF341 PLCB1 CMAHP MYB	3.77e-03	675	134	9	EFO_0004541
Disease	Profound Mental Retardation	TTI2 APC SYNGAP1 ASCC3	3.77e-03	139	134	4	C0020796
Disease	Mental Retardation, Psychosocial	TTI2 APC SYNGAP1 ASCC3	3.77e-03	139	134	4	C0025363
Disease	Mental deficiency	TTI2 APC SYNGAP1 ASCC3	3.77e-03	139	134	4	C0917816
Disease	Prostate cancer, familial	DOCK2 TCF4 MYO9B	3.86e-03	69	134	3	C2931456
Disease	breast size	DOCK4 ZNF365 ADSL	3.86e-03	69	134	3	EFO_0004884
Disease	gastric ulcer	MYO9B PLCL2	4.06e-03	21	134	2	EFO_0009454

Protein segments in the cluster

Peptide	Gene	Start	Entry
THSSPLDTIYYHREL	AGBL5	181	Q8NDL9
AHTQSVYNYHLSPRA	ERF	316	P50548
DPHGLYSLSLLHTYD	BACH1	316	O14867
FDYSHPRDVYSNLSH	B4GALT3	46	O60512
HTQAGYLLYAALTHK	ACSS1	306	Q9NUB1
QNPYAHSLTSALHYL	CFAP61	601	Q8NHU2
VRYLSTDPQHHAYDT	CSPG4	741	Q6UVK1
RYISEPYLALHEDSH	CACNA1E	2226	Q15878
DHAESTYGLYRTHLL	PGLS	86	O95336
HLSFVYPNDYTRLSH	B4GALNT3	371	Q6L9W6
NRPGLSYHYTHTHLA	DPF1	206	Q92782
PSYNADILLSHLHYL	ERG	181	P11308
LLQAYQFHAASPLHY	BTBD17	286	A6NE02
GFLLYHPSINDYIHS	AGAP2	706	Q99490
EILHRYLPYNSHAAS	CYB5D1	161	Q6P9G0
HSPYLQSYHNSSAAA	DLX6	6	P56179
YHLNPSSYTIDLLSA	COBLL1	91	Q53SF7
PHYNYSEALTFDSHK	NDST3	791	O95803
RAYTALHYLSHLSPG	CRYZL1	131	O95825
SLSLVFHAIDYHYIS	GPR107	306	Q5VW38
LPSHLSFTVYAAHNI	PIK3C2G	521	O75747
TFDYLLSHVHSPNAE	DAO	71	P14920
GYHKATLYHHPSLQS	PAK5	376	Q9P286
TLYHHPSLQSSSQYI	PAK5	381	Q9P286
EYQHHSRDYASHLSP	NCOR2	41	Q9Y618
HEYLSHPFAVSLYGS	LRP1B	1466	Q9NZR2
PSNYDLLRHLQYATH	MED12L	696	Q86YW9
SHLYSHLSSIYAKPQ	M1AP	446	Q8TC57
LHPEYNFTSQYLVHV	RPGRIP1L	651	Q68CZ1
PGLSYHYAHTHLASE	DPF3	211	Q92784
SSSYCSLHPHERLSY	TCF4	251	P15884
IHPYHSLSYTSGDTA	KIAA1109	2256	Q2LD37
PLHLAAQYGHYSTTE	GABPB1	41	Q06547
AAELHIVHYNSDLYP	CA12	141	O43570
DTHLGHYIYIPSRQD	KIF27	586	Q86VH2
LQHYTLEDIATSHLY	CBFA2T2	291	O43439
SLILYGTAEHPYHTF	PCSK6	626	P29122
VPLVTGYTTYDAHHS	IRF8	186	Q02556
EDCLYLSIYTPAHSH	CES2	121	O00748
ESYVHLDIYSGLNSH	FRYL	1506	O94915
KHYDLLSALSQTSYH	FRYL	1886	O94915
EDYFSHHLAVYNSPQ	FBXO39	201	Q8N4B4
AHSVLYLASPLASYV	DECR2	246	Q9NUI1
DIPHYTRLYSAGVAH	POU5F2	301	Q8N7G0
HTIFPSEYLSSHLEA	NCKAP1L	701	P55160
YHRSSLYCSDIPSIH	LEPR	466	P48357
YYHISEAQNVSSHVP	MYB	246	P10242
IHHELLAYLYSSADQ	DNM2	691	P50570
HHADSLYTYPVATQC	FSHB	86	P01225
AAPHSYSILVALFHT	OR8U9	146	P0C7N5
LHYLDLSYNHLTFIP	LRRC8B	681	Q6P9F7
DSPTALYHFNASLYL	MYBBP1A	916	Q9BQG0
SLFYLHNELGNIYTH	PAQR4	41	Q8N4S7
RSQISDHTTHPISYY	GGTLC3	11	B5MD39
PLSHYLVSSSHNTYL	PLCD1	301	P51178
LSLPTLIYYYAAHNH	P2RY4	86	P51582
PANTYASIDFLSHHL	IRS2	1316	Q9Y4H2
YETFHLSDLPSYTTH	OGDH	421	Q02218
VLSPEHSYSASGIYH	DNAH1	3906	Q9P2D7
DDHLQTPYHETVYSL	GSKIP	96	Q9P0R6
PYNSDTVLVHRVHSY	KDM1A	241	O60341
DASAYLTLPSYRHHV	DOCK2	561	Q92608
RSSYHSFVLYHSNSP	DOCK3	471	Q8IZD9
ASEYHSFVLYHNNSP	DOCK4	451	Q8N1I0
SLPHTSYSIVCYHVL	QRSL1	316	Q9H0R6
TPLEHHLYVVSYEAA	DPP9	521	Q86TI2
NIYSLAASSELPHVY	CYP2R1	51	Q6VVX0
SYLHLNPASYHIEAS	HYAL4	396	Q2M3T9
YSHVTSEYETNIHFP	ADCY9	881	O60503
ALSPHTVDYCHSYEL	HEPN1	51	Q6WQI6
SADHELLSPTNYHFL	MANBA	776	O00462
STHYNLHNLYGLTEA	GAA	566	P10253
QYEPHLLFSSESTLH	ITGA10	936	O75578
GDDHLYQHPSSAVLY	HGSNAT	476	Q68CP4
YQHPSSAVLYHTEVA	HGSNAT	481	Q68CP4
SPSHYALLQYHYGTL	EMC1	296	Q8N766
LHHLYIQERAGTSTY	CAPN6	436	Q9Y6Q1
TLGFHTHAEELYYLN	SCARA3	386	Q6AZY7
SLARHLQTYGEHYPL	BCKDHA	426	P12694
LDSHLHTPVYLFLSN	OR1E2	51	P47887
DQNHLPYIDYLHTGA	JARID2	931	Q92833
HALESYTTLPYHLRS	ADHFE1	246	Q8IWW8
SYRLHEAFSPVSYQH	F12	446	P00748
PLHLAAQYGHYSTAE	GABPB2	41	Q8TAK5
VISSVSYYTHRHGNP	USP9X	361	Q93008
HTYNYSVLLVDPASH	SEMA4F	61	O95754
TSEYFSLSHHPLDYR	SEMA3C	41	Q99985
YVASLHLPSFDAHLT	AHCYL1	491	O43865
DLVPNHLSYYLYNHV	LARS1	676	Q9P2J5
EPHNYEATISYLRHS	FYB2	326	Q5VWT5
PLSHYFINSSHNTYL	PLCL2	431	Q9UPR0
AYFSPIHSQLDHLLD	ADSL	431	P30566
VESDYTLLYLHHGLT	ARHGAP1	116	Q07960
TPYHVNLLLAGYDEH	PSMB2	96	P49721
ESNVYLNSFHYPDHS	PHLDB2	981	Q86SQ0
PNHLLYLYHSFTSQT	BRS3	286	P32247
YSGHLALRLYHITDQ	B3GNT2	311	Q9NY97
SSPHIYQVYSLHNVE	AKAP6	1281	Q13023
SYGQYPADLAHKIHS	APC	996	P25054
DPTNDHIYHSEYFLA	ASCC3	1226	Q8N3C0
TVTNHYQHLLSYSFP	ARMCX1	316	Q9P291
LIYISHLHSDHLSYP	CMAHP	86	Q9Y471
AEHLYHTLESSYQKA	CLASP1	521	Q7Z460
FYVHHDILLSAYPLS	PWP1	176	Q13610
TQPLSHYYINASHNT	PLCL1	401	Q15111
SRYLHAHLDTPLTEY	TTC13	436	Q8NBP0
YDLGVHQYSHSLLPQ	ZNF341	516	Q9BYN7
PSYVNLYSISHEHSK	ZNF365	96	Q70YC5
EYLEVYVSASEHPNH	TDRKH	306	Q9Y2W6
PAASILHSHSYSDEF	SYNGAP1	996	Q96PV0
FYAEHLSLHYPLEIS	TMPRSS7	251	Q7RTY8
VLYHAISNHLYTPEH	TTI2	291	Q6NXR4
QPLAHYFISSSHNTY	PLCD3	341	Q8N3E9
YASLDHASFDYDHLP	TMEM232	121	C9JQI7
PLSHYFITSSHNTYL	PLCH2	331	O75038
VDYPLHDLVLHTNYT	TNXB	3896	P22105
TLSQHTHDYPYSLVS	TMEM214	161	Q6NUQ4
PSSVSSSYNHLYLFH	UBR1	1426	Q8IWV7
LFVGSSHLYSDHYSP	TMPRSS12	11	Q86WS5
ADLTYPTRITHVYNH	TENM3	2251	Q9P273
YALHYERHSSNSLPG	VPS45	391	Q9NRW7
PLSHYFINSSHNTYL	PLCB1	321	Q9NQ66
ELHLIHYSYGVNSTE	TRB	61	P0DTU4
YLQSHPQHSVDRIYS	ZBTB20	231	Q9HC78
PTTLYLVHTDHAYQA	ZNF704	296	Q6ZNC4
TSHALDSHILDYYEN	THUMPD3	176	Q9BV44
PNVLFAYAHTLALYH	ZNHIT2	216	Q9UHR6
VTSLAYTHHGRQYLA	PSMD5	231	Q16401
NSFITDVDYLHHKYP	SLC29A4	86	Q7RTT9
ELHLIHYSYGVNSTE	TRBV25-1	61	A0A075B6N4
LYTAYKHNTHPTIED	USP34	171	Q70CQ2
YFSRSHLNYHQKAPA	ZNF22-AS1	71	Q5T742
HDIVYITLPLYHSSA	SLC27A6	256	Q9Y2P4
NYDPETYHATLTHSV	TEX2	556	Q8IWB9
HGYARLTLSLYDPHS	TTLL10	396	Q6ZVT0
GPSQAHSALYLSSHY	TOX	361	O94900
HLHNYALSYTGSDNI	ZBTB26	236	Q9HCK0
LQHNHEYRAYEDSSP	TRIM6	406	Q9C030
PSHHDIALAFYETAS	TYK2	646	P29597
TSHPYQAALYTSGHL	KLK6	31	Q92876
TTLHVYPDLYHSQFT	NALCN	461	Q8IZF0
HYYESDTLLHSFQVL	NADSYN1	56	Q6IA69
AYHLHIYPQLSTTES	MYO9B	16	Q13459
QSYHHYTLLPDALNV	NEB	1651	P20929
DSHFPYDLHLRSQSL	NEUROD6	311	Q96NK8