Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	LRRC37AB_C	LRRC37A3 LRRC37A2 LRRC37A	6.30e-07	4	102	3	IPR029423
Domain	LRRC37AB_C	LRRC37A3 LRRC37A2 LRRC37A	6.30e-07	4	102	3	PF14914
Domain	LRRC37_N	LRRC37A3 LRRC37A2 LRRC37A	6.30e-07	4	102	3	IPR032754
Domain	LRRC37	LRRC37A3 LRRC37A2 LRRC37A	6.30e-07	4	102	3	PF15779
Domain	LRRC37A/B-like	LRRC37A3 LRRC37A2 LRRC37A	6.30e-07	4	102	3	IPR015753
Domain	Glyco_trans_13	POMGNT1 MGAT1	2.95e-05	2	102	2	IPR004139
Domain	GNT-I	POMGNT1 MGAT1	2.95e-05	2	102	2	PF03071
Domain	IQ	IQCH MYO5A MYO5C ADGB CAMTA1	8.12e-05	81	102	5	SM00015
Domain	IQ_motif_EF-hand-BS	IQCH MYO5A MYO5C ADGB CAMTA1	1.34e-04	90	102	5	IPR000048
Domain	IQ	IQCH MYO5A MYO5C ADGB CAMTA1	1.56e-04	93	102	5	PS50096
Domain	SH2	NCK1 STAT5A BMX LYN HCK	2.30e-04	101	102	5	PF00017
Domain	FerI	DYSF OTOF	2.92e-04	5	102	2	SM01202
Domain	FerB	DYSF OTOF	2.92e-04	5	102	2	SM01201
Domain	Ferlin_B-domain	DYSF OTOF	2.92e-04	5	102	2	IPR012561
Domain	Ferlin_C	DYSF OTOF	2.92e-04	5	102	2	PF16165
Domain	Ferlin_C	DYSF OTOF	2.92e-04	5	102	2	IPR032362
Domain	FerIin_dom	DYSF OTOF	2.92e-04	5	102	2	IPR012968
Domain	FerI	DYSF OTOF	2.92e-04	5	102	2	PF08151
Domain	FerB	DYSF OTOF	2.92e-04	5	102	2	PF08150
Domain	Myosin_S1_N	MYO5A MYO5C	2.92e-04	5	102	2	IPR008989
Domain	SH2	NCK1 STAT5A BMX LYN HCK	3.42e-04	110	102	5	SM00252
Domain	SH2	NCK1 STAT5A BMX LYN HCK	3.57e-04	111	102	5	PS50001
Domain	SH2	NCK1 STAT5A BMX LYN HCK	3.72e-04	112	102	5	IPR000980
Domain	-	NCK1 STAT5A BMX LYN HCK	3.72e-04	112	102	5	3.30.505.10
Domain	Dilute_dom	MYO5A MYO5C	4.37e-04	6	102	2	IPR002710
Domain	DIL	MYO5A MYO5C	4.37e-04	6	102	2	PF01843
Domain	DILUTE	MYO5A MYO5C	4.37e-04	6	102	2	PS51126
Domain	DIL	MYO5A MYO5C	4.37e-04	6	102	2	SM01132
Domain	-	POMGNT1 EXTL1 MGAT1 B4GALNT3	1.01e-03	81	102	4	3.90.550.10
Domain	Nucleotide-diphossugar_trans	POMGNT1 EXTL1 MGAT1 B4GALNT3	1.38e-03	88	102	4	IPR029044
Pathway	REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING	STAT5A LYN PRLR	4.57e-05	16	63	3	MM15710
Pathway	PID_PTP1B_PATHWAY	STAT5A LYN HCK PRLR	8.35e-05	52	63	4	M50
Pathway	REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING	STAT5A LYN PRLR	1.61e-04	24	63	3	M519
Pathway	REACTOME_INACTIVATION_OF_CSF3_G_CSF_SIGNALING	STAT5A LYN HCK	1.82e-04	25	63	3	M41829
Pathway	KEGG_MEDICUS_REFERENCE_PRL_JAK_STAT_SIGNALING_PATHWAY	STAT5A PRLR	1.95e-04	5	63	2	M49006
Pathway	REACTOME_PHOSPHOLIPID_METABOLISM	GPAM PLA2R1 BMX PNPLA6 SBF1 INPP5J	2.35e-04	196	63	6	MM14591
Pathway	REACTOME_SIGNALING_BY_CSF3_G_CSF	STAT5A LYN HCK	3.17e-04	30	63	3	M41825
Pathway	REACTOME_PHOSPHOLIPID_METABOLISM	GPAM PLA2R1 BMX PNPLA6 SBF1 INPP5J	3.50e-04	211	63	6	M649
Pathway	REACTOME_PI_METABOLISM	BMX PNPLA6 SBF1 INPP5J	3.84e-04	77	63	4	MM14590
Pathway	REACTOME_ERYTHROPOIETIN_ACTIVATES_STAT5	STAT5A LYN	4.07e-04	7	63	2	M27907
Pathway	REACTOME_PI_METABOLISM	BMX PNPLA6 SBF1 INPP5J	5.35e-04	84	63	4	M676
Pubmed	Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5.	STAT5A LYN HCK	1.07e-07	4	105	3	18246197
Pubmed	Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.	LRRC37A3 LRRC37A2 LRRC37A	1.07e-07	4	105	3	22419166
Pubmed	Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage.	STAT5A LYN HCK	5.31e-07	6	105	3	17218386
Pubmed	The Cdc42-associated kinase ACK1 is not autoinhibited but requires Src for activation.	NCK1 LYN HCK	1.48e-06	8	105	3	21309750
Pubmed	Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck.	NCK1 LYN HCK	2.22e-06	9	105	3	10428862
Pubmed	Evolutionary dynamism of the primate LRRC37 gene family.	LRRC37A3 LRRC37A2 LRRC37A	3.16e-06	10	105	3	23064749
Pubmed	Expression of tyrosine kinase gene in mouse thymic stromal cells.	BMX LYN HCK	3.16e-06	10	105	3	8943574
Pubmed	Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy.	C3 LYN HCK	5.77e-06	12	105	3	16872848
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CYLD PDE9A MYO5A RBL2 IFT172 NCK1 OTOF LMO7 MORF4L2 NAV3 ATM HERC2 CARS2 ZNF292 BRWD1	7.43e-06	1285	105	15	35914814
Pubmed	Cells with minimal expression of the JAK/STAT pathway related proteins STAT5a and the prolactin receptor: evidence of an alternate prolactin receptor isoform in breast disease.	STAT5A PRLR	9.03e-06	2	105	2	20214633
Pubmed	LynA regulates an inflammation-sensitive signaling checkpoint in macrophages.	LYN HCK	9.03e-06	2	105	2	26517880
Pubmed	Ectopic serotonin production in β-cell specific transgenic mice.	STAT5A PRLR	9.03e-06	2	105	2	29223399
Pubmed	Lyn tyrosine kinase promotes silencing of ATM-dependent checkpoint signaling during recovery from DNA double-strand breaks.	ATM LYN	9.03e-06	2	105	2	25173936
Pubmed	Human myosin-Vc is a novel class V myosin expressed in epithelial cells.	MYO5A MYO5C	9.03e-06	2	105	2	11870218
Pubmed	Identification of the Isoform-specific Interactions between the Tail and the Head of Class V Myosin.	MYO5A MYO5C	9.03e-06	2	105	2	26912658
Pubmed	Targeted proteome analysis with isotope-coded protein labels for monitoring the influence of dietary phytochemicals on the expression of cytoprotective proteins in primary human colon cells.	TXNRD1 NQO1	9.03e-06	2	105	2	28688915
Pubmed	Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome.	PACSIN1 NCK1 LYN HCK	2.55e-05	56	105	4	22745667
Pubmed	Selective coupling of STAT factors to the mouse prolactin receptor.	STAT5A PRLR	2.70e-05	3	105	2	9874248
Pubmed	Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn.	LYN HCK	2.70e-05	3	105	2	10684859
Pubmed	HMGN2 inducibly binds a novel transactivation domain in nuclear PRLr to coordinate Stat5a-mediated transcription.	STAT5A PRLR	2.70e-05	3	105	2	21816901
Pubmed	Induction of complementary function reductase enzymes in colon cancer cells by dithiole-3-thione versus sodium selenite.	TXNRD1 NQO1	2.70e-05	3	105	2	25179160
Pubmed	Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5.	STAT5A PRLR	2.70e-05	3	105	2	12954715
Pubmed	The JAK-STAT transcriptional regulator, STAT-5, activates the ATM DNA damage pathway to induce HPV 31 genome amplification upon epithelial differentiation.	STAT5A ATM	2.70e-05	3	105	2	23593005
Pubmed	Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn.	LYN HCK	2.70e-05	3	105	2	9151903
Pubmed	The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn.	LYN HCK	2.70e-05	3	105	2	17513616
Pubmed	The C2 domains of otoferlin, dysferlin, and myoferlin alter the packing of lipid bilayers.	DYSF OTOF	2.70e-05	3	105	2	23859474
Pubmed	Structural insights into the globular tails of the human type v myosins Myo5a, Myo5b, And Myo5c.	MYO5A MYO5C	2.70e-05	3	105	2	24339992
Pubmed	The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4.	LYN HCK	2.70e-05	3	105	2	16140274
Pubmed	SRC-dependent outside-in signalling is a key step in the process of autoregulation of beta2 integrins in polymorphonuclear cells.	LYN HCK	2.70e-05	3	105	2	14969582
Pubmed	HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction.	LYN HCK	2.70e-05	3	105	2	16849330
Pubmed	Genetic ablation of complement C3 attenuates muscle pathology in dysferlin-deficient mice.	DYSF C3	2.70e-05	3	105	2	21060153
Pubmed	Src family kinase-mediated negative regulation of hematopoietic stem cell mobilization involves both intrinsic and microenvironmental factors.	LYN HCK	2.70e-05	3	105	2	17588471
Pubmed	Deficiency of Src family kinases compromises the repopulating ability of hematopoietic stem cells.	LYN HCK	2.70e-05	3	105	2	18346837
Pubmed	Characterization of the human B cell RAG-associated gene, hBRAG, as a B cell receptor signal-enhancing glycoprotein dimer that associates with phosphorylated proteins in resting B cells.	LYN HCK	2.70e-05	3	105	2	10749872
Pubmed	Resting murine neutrophils express functional alpha 4 integrins that signal through Src family kinases.	LYN HCK	2.70e-05	3	105	2	11238661
Pubmed	FerA is a Membrane-Associating Four-Helix Bundle Domain in the Ferlin Family of Membrane-Fusion Proteins.	DYSF OTOF	2.70e-05	3	105	2	30026467
Pubmed	Role of Src kinases and Syk in Fcgamma receptor-mediated phagocytosis and phagosome-lysosome fusion.	LYN HCK	2.70e-05	3	105	2	11698501
Pubmed	Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner.	LYN HCK	2.70e-05	3	105	2	22393415
Pubmed	Structural insights into functional overlapping and differentiation among myosin V motors.	MYO5A MYO5C	2.70e-05	3	105	2	24097982
Pubmed	Genome-wide association study of serum iron phenotypes in premenopausal women of European descent.	HFE SLC17A2	2.70e-05	3	105	2	26852655
Pubmed	The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.	LYN HCK	2.70e-05	3	105	2	25225462
Pubmed	Analysis of intracellular tyrosine phosphorylation in circulating neutrophils as a rapid assay for the in vivo effect of oral tyrosine kinase inhibitors.	LYN HCK	2.70e-05	3	105	2	37089957
Pubmed	Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis.	LYN HCK	2.70e-05	3	105	2	16772601
Pubmed	Phospho-tyrosine dependent protein-protein interaction network.	MAGEC3 NCK1 STAT5A BMX LYN HCK PRRC2B BRWD1	3.59e-05	410	105	8	25814554
Pubmed	Lyn deficiency reduces GATA-1, EKLF and STAT5, and induces extramedullary stress erythropoiesis.	STAT5A LYN	5.40e-05	4	105	2	15516974
Pubmed	Identification of UNC119 as a novel activator of SRC-type tyrosine kinases.	LYN HCK	5.40e-05	4	105	2	12496276
Pubmed	The Syk Tyrosine Kinase Is Required for Skin Inflammation in an In Vivo Mouse Model of Epidermolysis Bullosa Acquisita.	LYN HCK	5.40e-05	4	105	2	28576735
Pubmed	Affinity of Src family kinase SH3 domains for HIV Nef in vitro does not predict kinase activation by Nef in vivo.	LYN HCK	5.40e-05	4	105	2	10642173
Pubmed	Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in regulation of adhesion-independent and -dependent neutrophil reactive oxygen species generation.	LYN HCK	5.40e-05	4	105	2	23447687
Pubmed	Conserved residues in the HIV-1 Nef hydrophobic pocket are essential for recruitment and activation of the Hck tyrosine kinase.	LYN HCK	5.40e-05	4	105	2	15491611
Pubmed	Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase.	LYN HCK	5.40e-05	4	105	2	18625913
Pubmed	The conserved core of human immunodeficiency virus type 1 Nef is essential for association with Lck and for enhanced viral replication in T-lymphocytes.	LYN HCK	5.40e-05	4	105	2	10544125
Pubmed	A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages.	LYN HCK	5.40e-05	4	105	2	9314552
Pubmed	Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase.	CRY1 HERC2	5.40e-05	4	105	2	20304803
Pubmed	Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F.	LYN HCK	5.40e-05	4	105	2	17183644
Pubmed	Alternative splicing in class V myosins determines association with Rab10.	MYO5A MYO5C	5.40e-05	4	105	2	19008234
Pubmed	Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4.	LYN HCK	5.40e-05	4	105	2	7859737
Pubmed	The Bmx tyrosine kinase induces activation of the Stat signaling pathway, which is specifically inhibited by protein kinase Cdelta.	STAT5A BMX	5.40e-05	4	105	2	9373245
Pubmed	PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development.	STAT5A PRLR	5.40e-05	4	105	2	20075866
Pubmed	SOCS3 promotes apoptosis of mammary differentiated cells.	STAT5A PRLR	5.40e-05	4	105	2	16289036
Pubmed	The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection.	LYN HCK	5.40e-05	4	105	2	27358479
Pubmed	Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction.	LYN HCK	5.40e-05	4	105	2	8058772
Pubmed	Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects.	STAT5A PRLR	5.40e-05	4	105	2	11133161
Pubmed	Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome.	NCK1 LYN HCK	5.86e-05	25	105	3	16374509
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	CYLD NRDE2 CCDC9B MYO5A DYSF CPED1 SBF1 LMO7 PRRC2B ZNF292	7.01e-05	724	105	10	36232890
Pubmed	Oxidative stress reprograms lipopolysaccharide signaling via Src kinase-dependent pathway in RAW 264.7 macrophage cell line.	LYN HCK	8.97e-05	5	105	2	12896983
Pubmed	Targeting Lyn tyrosine kinase through protein fusions encompassing motifs of Cbp (Csk-binding protein) and the SOCS box of SOCS1.	LYN HCK	8.97e-05	5	105	2	22364282
Pubmed	Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa.	LYN HCK	8.97e-05	5	105	2	9268059
Pubmed	Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling.	LYN HCK	8.97e-05	5	105	2	15784897
Pubmed	RA70 is a src kinase-associated protein expressed ubiquitously.	LYN HCK	8.97e-05	5	105	2	9837776
Pubmed	Src family kinases mediate neutrophil adhesion to adherent platelets.	LYN HCK	8.97e-05	5	105	2	17095622
Pubmed	The accessory factor Nef links HIV-1 to Tec/Btk kinases in an Src homology 3 domain-dependent manner.	BMX HCK	8.97e-05	5	105	2	24722985
Pubmed	IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina.	LYN HCK	8.97e-05	5	105	2	21220696
Pubmed	O-glycans direct selectin ligands to lipid rafts on leukocytes.	LYN HCK	8.97e-05	5	105	2	26124096
Pubmed	Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters.	LYN HCK	8.97e-05	5	105	2	16425036
Pubmed	Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor.	NEK3 PRLR	8.97e-05	5	105	2	15618286
Pubmed	Activation of phospholipase Cgamma2 by tyrosine phosphorylation.	LYN HCK	8.97e-05	5	105	2	12181444
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	MYO5A CD177 SI HID1 DYSF MYO5C MGAT1 C3 SCPEP1 CAPN5 LYN ALDH7A1	9.53e-05	1070	105	12	23533145
Pubmed	SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome.	NCK1 BMX HCK	1.24e-04	32	105	3	22974441
Pubmed	Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.	STAT5A PRLR	1.34e-04	6	105	2	12388746
Pubmed	Differential involvement of Src family kinases in Fc gamma receptor-mediated phagocytosis.	LYN HCK	1.34e-04	6	105	2	10861086
Pubmed	A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators.	AOX1 LYN	1.34e-04	6	105	2	1825055
Pubmed	Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk.	LYN HCK	1.34e-04	6	105	2	8657103
Pubmed	Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2.	LYN HCK	1.34e-04	6	105	2	16684964
Pubmed	Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase.	LYN HCK	1.34e-04	6	105	2	1720539
Pubmed	The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity.	LYN HCK	1.34e-04	6	105	2	14993658
Pubmed	CARD9 mediates dendritic cell-induced development of Lyn deficiency-associated autoimmune and inflammatory diseases.	LYN HCK	1.34e-04	6	105	2	31594855
Pubmed	SOCS1 links cytokine signaling to p53 and senescence.	STAT5A ATM	1.34e-04	6	105	2	20005840
Pubmed	Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-C gamma 1 in human T lymphocytes.	LYN HCK	1.34e-04	6	105	2	10586033
Pubmed	Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase.	LYN HCK	1.34e-04	6	105	2	9890970
Pubmed	Bach1 repression of ferritin and thioredoxin reductase1 is heme-sensitive in cells and in vitro and coordinates expression with heme oxygenase1, beta-globin, and NADP(H) quinone (oxido) reductase1.	TXNRD1 NQO1	1.34e-04	6	105	2	17901053
Pubmed	Next-generation sequencing to generate interactome datasets.	ZMYND19 PDE9A FA2H RUSC1 KBTBD7 BMX ZNF276 SYT11 MORF4L2 ZBED1 HCK PRRC2B	1.82e-04	1147	105	12	21516116
Pubmed	Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro.	LYN HCK	1.88e-04	7	105	2	1689310
Pubmed	Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice.	CRY1 ATM	1.88e-04	7	105	2	20539819
Pubmed	Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin αLβ2.	LYN HCK	1.88e-04	7	105	2	22511754
Pubmed	Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome.	LYN HCK	1.88e-04	7	105	2	21860019
Pubmed	Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases.	LYN HCK	1.88e-04	7	105	2	10858437
Pubmed	Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis.	STAT5A PRLR	1.88e-04	7	105	2	12040017
Pubmed	Proline-rich sequences that bind to Src homology 3 domains with individual specificities.	LYN HCK	1.88e-04	7	105	2	7536925
Pubmed	Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells.	LYN HCK	1.88e-04	7	105	2	9020138
Cytoband	12q23-q24.1	CRY1 TXNRD1	7.87e-05	6	106	2	12q23-q24.1
Cytoband	15q21	MYO5A MYO5C	2.87e-04	11	106	2	15q21
Cytoband	8q13	C8orf34 LYN	3.43e-04	12	106	2	8q13
Cytoband	Ensembl 112 genes in cytogenetic band chr16q12	CYLD TENT4B RBL2	1.79e-03	103	106	3	chr16q12
Cytoband	2q33	SATB2 AOX1	2.06e-03	29	106	2	2q33
Cytoband	16q22.1	CARMIL2 ZDHHC1 NQO1	2.16e-03	110	106	3	16q22.1
Cytoband	16q12.1	CYLD TENT4B	2.82e-03	34	106	2	16q12.1
Cytoband	Ensembl 112 genes in cytogenetic band chr16q24	ZC3H18 ZNF276 KLHDC4	3.93e-03	136	106	3	chr16q24
GeneFamily	Ferlin family	DYSF OTOF FER1L4	1.10e-06	6	70	3	828
GeneFamily	Myosins, class V	MYO5A MYO5C	4.42e-05	3	70	2	1100
GeneFamily	SH2 domain containing	NCK1 STAT5A BMX LYN HCK	4.47e-05	101	70	5	741
GeneFamily	C2 domain containing\|Calpains	ADGB CAPN5	1.50e-03	15	70	2	975
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	HFE BRPF3 RBL2 ZDHHC1 PNPLA6 ZNF589	1.52e-06	150	105	6	b6f1fc62d08199fed6156c7cd32f66d9926531b5
ToppCell	droplet-Liver-LIVER-NPC-1m-Lymphocytic-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CARMIL2 MYO5A ARID4A PACSIN1 SLC25A35 N4BP2	3.15e-06	170	105	6	3ad9f950b87ee98f025ab9b4a8ed551e6a9b4764
ToppCell	droplet-Bladder\|droplet / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FA2H PLA2R1 FER1L4 CERS3 NQO1 CAPN5	5.96e-06	190	105	6	170484f7a6f0a0d0792bbe1bb04abad060b7188e
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-ciliated_cell-Epi-Ciliated\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	IQCH DNAH12 LMO7 NQO1 RASSF9 CFAP44	6.33e-06	192	105	6	a22952b885c8a7704a4a9602fa03e4f2c786bf75
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-ciliated_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	IQCH DNAH12 LMO7 NQO1 RASSF9 CFAP44	6.33e-06	192	105	6	dcf2d0c2e8868104c4dba410456207f0d947029a
ToppCell	tumor_Lymph_Node_/_Brain\|World / Location, Cell class and cell subclass	FA2H MYO5C TXNRD1 LMO7 SEMA3B C3	7.12e-06	196	105	6	b39f938cbef54f08c53035738b97c76e7295733a
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	GPATCH2 MYO5C MAB21L3 LMO7 C3 CAMTA1	7.33e-06	197	105	6	b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IQCH C8orf34 ADGB DNAH12 MDH1B CFAP44	7.33e-06	197	105	6	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	LPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	IQCH ADGB OTOF MDH1B B4GALNT3 CFAP44	7.99e-06	200	105	6	96701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCell	severe-Myeloid-Neutrophils_4\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CD177 DYSF BMX TSEN34 LYN HCK	7.99e-06	200	105	6	b665f36dcf3c9d3981ee96f2973512f751612542
ToppCell	TCGA-Mesothelium-Primary_Tumor-Mesothelioma-Epitheliod-3\|TCGA-Mesothelium / Sample_Type by Project: Shred V9	RBL2 FA2H GPATCH2 RASSF9 ZNF292	1.84e-05	137	105	5	a1e34ebbeda3d5a4f14917282d44fcb4dcbf3133
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-AT1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FA2H MYO5C LMO7 SEMA3B RASSF9	3.99e-05	161	105	5	1e17a993126e1f2a25ee7dfbb95a74ccb2a26791
ToppCell	E16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GPAM MYO5C LMO7 SEMA3B HCK	4.36e-05	164	105	5	fe11fcce4ba7f44ba2989ea3705916b67e75f8e7
ToppCell	E16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GPAM MYO5C LMO7 SEMA3B HCK	4.36e-05	164	105	5	b6beb8548ac0dd07e8a580a938e5ee4bf25a3c1f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CYLD DYSF ADGB LYN HCK	4.61e-05	166	105	5	63dc58864268b4e7779e4c45155022556fc634f9
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GPAM ADGB DNAH12 NQO1 MDH1B	4.88e-05	168	105	5	9a8709d34865cfa668d8f3335dc34fc86fc32482
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AOX1 CPED1 NAV3 C3 CLEC4C	5.31e-05	171	105	5	5d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCell	droplet-Lung-21m-Epithelial-airway_epithelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IQCH C8orf34 ADGB CFAP44 PRLR	5.61e-05	173	105	5	a809be2630d2b91b53b82b5e2bb99e05524597c1
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_E\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	ATG101 SCPEP1 CAMTA1 PRRC2B	5.62e-05	88	105	4	142d2e00ef19c0ad011a21945bf1111271056eae
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HFE SATB2 AFF2 CERS3 C3	5.93e-05	175	105	5	cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCell	normal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells\|normal_Lymph_Node / Location, Cell class and cell subclass	CCDC9B LRRC37A3 PACSIN1 LRRC37A CLEC4C	5.93e-05	175	105	5	29fbdfe1d3bfcb063be2bced0128a33176c5b78f
ToppCell	droplet-Lung-21m-Epithelial-airway_epithelial-lung_ciliated_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IQCH C8orf34 MYO5C ADGB CFAP44	6.26e-05	177	105	5	d947ba38db1772fc5fdcdc211f7511c4aa699dee
ToppCell	droplet-Lung-21m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IQCH C8orf34 MYO5C ADGB CFAP44	6.26e-05	177	105	5	d5640f0097878f0dac671e51dc51310278bb2682
ToppCell	droplet-Lung-LUNG-30m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HID1 ZDHHC1 BMX LMO7 CAPN5	6.60e-05	179	105	5	a09647750eba9d93c5efc1db3b555fefb5eec7b5
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HEATR4 HID1 DYSF RASSF9 LYN	6.60e-05	179	105	5	abc6797bd3884aa75dca58fcb2523ee321243ab1
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HEATR4 HID1 DYSF RASSF9 LYN	6.60e-05	179	105	5	0b996d6e881f31e6b80d359f7caac70ecdeb9982
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC17A2 CPED1 LMO7 CERS3 SEMA3B	7.14e-05	182	105	5	573771130247e869e4e58f22d4a1cb31989635cf
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC17A2 CPED1 LMO7 CERS3 SEMA3B	7.14e-05	182	105	5	6cfaa2b3b3974c13b01c943f4adb70768dcc35e4
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HID1 MYO5C LMO7 CAPN5 PRLR	7.32e-05	183	105	5	7eaa6ef7c6cf848fd6489f97677f4406318da22f
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO5C LMO7 SEMA3B C3 RASSF9	7.51e-05	184	105	5	42ce855b4f8475a8298192feec785bdc69bc5bb0
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF831 DYSF BMX RASSF9 LYN	7.71e-05	185	105	5	fb84fcf7f51f53489bcb3962fa9cb483e48257ed
ToppCell	5'-Adult-Distal_Rectal-Epithelial-Tuft-related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SATB2 PDE9A FA2H CAPN5 B4GALNT3	7.91e-05	186	105	5	4046b701aa29712d9f7c774f8955215122c3c003
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO5C LMO7 SEMA3B C3 RASSF9	7.91e-05	186	105	5	4e94158db52df41d71e67b02b9895a358eebee0f
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF831 DYSF BMX RASSF9 LYN	7.91e-05	186	105	5	9d250d5ae7cf9129be05b41d70cb6c3a046c5f1e
ToppCell	Tuft\|World / Class top	SATB2 BMX PNPLA6 HCK INPP5J	7.91e-05	186	105	5	f4d83f15ab7b49c0920a322cd832413ece7c9948
ToppCell	5'-Adult-Distal_Rectal-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SATB2 PDE9A FA2H CAPN5 B4GALNT3	7.91e-05	186	105	5	bd5837033c1ffcbe5dd30195cc4846a2ba351bcd
ToppCell	P15-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SLC17A2 CPED1 LMO7 SEMA3B HCK	7.91e-05	186	105	5	521e6e007bbae73e7328153aa170cf04ca3c1093
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZDHHC1 ADGB DNAH12 NQO1 MDH1B	7.91e-05	186	105	5	903af26a63ec4b1755ab5cb81dfeb8dbd14bc5db
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HID1 MYO5C SLC25A35 MDH1B PRLR	7.91e-05	186	105	5	02fbb02c495e7d64c4ab50e42e5197782f2c0816
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MYO5A FA2H HID1 MYO5C LMO7	8.11e-05	187	105	5	db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ELAPOR2 MYO5C LMO7 SEMA3B C3	8.11e-05	187	105	5	58d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCell	normal_Lung-Myeloid_cells-pDCs\|normal_Lung / Location, Cell class and cell subclass	CCDC9B PACSIN1 CPED1 N4BP2 CLEC4C	8.11e-05	187	105	5	d36751372fd40a46441f07735c9c3c5dcb503f24
ToppCell	(1)_T_CD4_naive\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	CYLD RBL2 LMO7 N4BP2 ATM	8.32e-05	188	105	5	b8f67ac2faadd5b848955e43ab5d6cf5e49b3681
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CD177 DYSF BMX LYN HCK	8.32e-05	188	105	5	aa46073e2940dc1d2020b2e259bf0fc06cb990ee
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CD177 DYSF BMX LYN HCK	8.32e-05	188	105	5	04814b78da936a51a497e23060d19ca0d619e250
ToppCell	droplet-Marrow-nan-18m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATG101 CD177 C3 LYN HCK	8.32e-05	188	105	5	fa7a612b0a2b35de5f76a0408168dabe5db00773
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_granulocytic-neutrophil\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CD177 DYSF BMX MAB21L3 HCK	8.53e-05	189	105	5	235c24eeab5139f5821fccd5c879d8787682f4ef
ToppCell	COVID-19-lung-AT2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ELAPOR2 C8orf34 MYO5C LMO7 C3	8.74e-05	190	105	5	27a1a86620fe9b5ee930d388b32352206485e6d0
ToppCell	ASK454-Epithelial-Ciliated\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	CRY1 ADGB DNAH12 MDH1B CFAP44	8.74e-05	190	105	5	5cea6480f08253d7adf484e511d3fdfa96641268
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ELAPOR2 C8orf34 MYO5C LMO7 B4GALNT3	8.96e-05	191	105	5	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	COVID-19-lung-Macrophage_PPARGhi_CD5Lhi\|lung / Disease (COVID-19 only), tissue and cell type	MYO5A MGAT1 PNPLA6 LYN HCK	8.96e-05	191	105	5	dab953682b8c9ed680a799161f837f792a7e4f33
ToppCell	P07-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SLC17A2 LMO7 CERS3 SEMA3B HCK	8.96e-05	191	105	5	0f360766490bef3495c42f6421b22a988cfc68fb
ToppCell	mild-Lymphocytic-CD4_T_cells_2\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CD177 DYSF TSEN34 LYN HCK	9.18e-05	192	105	5	4cd8f572e067bf5fe22f62fa868d7d332f097a8c
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC17A2 LMO7 CERS3 SEMA3B HCK	9.18e-05	192	105	5	790282d4232311df3dac4ad97c80fc53443beccc
ToppCell	15-Trachea-Epithelial-Intermediate_ciliated\|Trachea / Age, Tissue, Lineage and Cell class	IFT172 ADGB DNAH12 CAPN5 CFAP44	9.18e-05	192	105	5	9cbe961a800c981cdc742a47ed18e9c8eb6430bd
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC17A2 LMO7 CERS3 SEMA3B HCK	9.18e-05	192	105	5	b2d9bffccd6264b4f12d88a0780646ee0b41969f
ToppCell	IPF-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	IQCH C8orf34 ADGB DNAH12 CFAP44	9.18e-05	192	105	5	d903bbd6c18e29e2c4cdedeb3fea1fd5ad7baa11
ToppCell	COPD-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	IQCH C8orf34 ADGB DNAH12 CFAP44	9.18e-05	192	105	5	eab1105cd1a98cfcd3d74dc5c9b89e1799bba59e
ToppCell	IPF-Epithelial-Ciliated\|IPF / Disease state, Lineage and Cell class	IQCH C8orf34 ADGB DNAH12 CFAP44	9.18e-05	192	105	5	354adc1354bf596fbc60dd45c0169688e6f45165
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	IQCH C8orf34 ADGB DNAH12 CFAP44	9.41e-05	193	105	5	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE9A HID1 NQO1 LYN PRLR	9.41e-05	193	105	5	1526f51b589a7dc7a28f35f0e788dc38d338d2bc
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW10-Myeloid\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	STAT5A C3 LYN HCK CLEC4C	9.64e-05	194	105	5	4f28841c7f37884fc34c6689cd6976c6559d23f1
ToppCell	NS-critical-d_07-13-Epithelial-Ciliated\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ZDHHC1 ADGB DNAH12 MDH1B CFAP44	9.64e-05	194	105	5	1ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCell	severe-Myeloid-Neutrophils_3\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CD177 DYSF TSEN34 LYN HCK	9.64e-05	194	105	5	1f8edab1c8ba48bc0114429ea47aab378b5830b7
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW10-Myeloid-Microglia\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	STAT5A C3 LYN HCK CLEC4C	9.64e-05	194	105	5	459e836bcdb6742333684ac23d960efa5e99702f
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IFT172 ADGB DNAH12 NQO1 CFAP44	9.64e-05	194	105	5	a46238514bca920c3e3713d23c18ba24a09e2a29
ToppCell	COVID-19-lung-Macrophage_CD163hi_MERTKhi\|lung / Disease (COVID-19 only), tissue and cell type	MYO5A DYSF MGAT1 LYN HCK	9.87e-05	195	105	5	148fff8c3c9ba45ec36e98dff1be57e3f8294506
ToppCell	critical-Epithelial-Ciliated\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ZDHHC1 ADGB DNAH12 MDH1B CFAP44	1.01e-04	196	105	5	27b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCell	(05)_Ciliated\|World / shred by cell type and Timepoint	CD177 IFT172 ADGB DNAH12 MDH1B	1.04e-04	197	105	5	fee3cd16af8eea697cd64e8f64af505aaa2ac4b0
ToppCell	PSB-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	C8orf34 ADGB DNAH12 MDH1B CFAP44	1.04e-04	197	105	5	6865f4831eb23794fb88a8649d48d497bbae3f44
ToppCell	Control_saline-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control_saline / Treatment groups by lineage, cell group, cell type	ELAPOR2 GPAM MYO5C LMO7 C3	1.04e-04	197	105	5	44a59dfb889577b3160a5b13ada1276771a00241
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IFT172 ADGB DNAH12 NQO1 CFAP44	1.04e-04	197	105	5	91637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IFT172 ADGB DNAH12 NQO1 CFAP44	1.04e-04	197	105	5	22c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell	COVID-19-lung-Macrophage_VCANhi_FCN1hi\|lung / Disease (COVID-19 only), tissue and cell type	CD177 DYSF OTOF LYN HCK	1.04e-04	197	105	5	a0f8a992282a6d64890f5574c7c9741fcb38dadd
ToppCell	severe-Lymphocytic-CD4_T_cells_2\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CD177 DYSF TSEN34 LYN HCK	1.04e-04	197	105	5	3b71e523d8a68f131def17233385df371db70db5
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IFT172 ADGB DNAH12 NQO1 CFAP44	1.04e-04	197	105	5	3bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell	10x5'v1-week_12-13-Myeloid_neutrophil-granulo-neutrophil-neutrophil\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	DYSF BMX CARS2 LYN HCK	1.04e-04	197	105	5	8dd10962b6ba587512b2e68c762ade68c751cbc8
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IFT172 ADGB DNAH12 NQO1 CFAP44	1.04e-04	197	105	5	87db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCell	Control_saline-Epithelial_alveolar-AT_2\|Control_saline / Treatment groups by lineage, cell group, cell type	ELAPOR2 GPAM MYO5C LMO7 C3	1.04e-04	197	105	5	b8f62fcd6eb8f47b3cc41f616126f82c68a36e87
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-F\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	CD177 AOX1 NQO1 C3 CAPN5	1.04e-04	197	105	5	fbff2fb7a8142b88c9dc71aa10980f4350b7e081
ToppCell	COVID-19-lung-Macrophage_VCANhi_FCN1hi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DYSF PNPLA6 OTOF LYN HCK	1.06e-04	198	105	5	ea34096bee852a7e996f097fa279381afa8f86ff
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	GPAM MYO5C MAB21L3 LMO7 C3	1.06e-04	198	105	5	285f729140b1df029c24f6ca1d2438470ac51794
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CD177 DYSF SCPEP1 LYN HCK	1.06e-04	198	105	5	df546a9afc0e15398f33c1b511c7281771f9aea0
ToppCell	severe_influenza-Non-classical_Monocyte\|World / disease group, cell group and cell class (v2)	ZDHHC1 PNPLA6 C3 LYN HCK	1.06e-04	198	105	5	790ee20abc9666b8095675b0d445c0914ee70ea3
ToppCell	Tracheal-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Duct\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	HID1 MYO5C LMO7 SEMA3B C3	1.09e-04	199	105	5	ef1a0c278c23614fd6a3218a9733abe6ecd6f686
ToppCell	tumor_Lymph_Node_/_Brain-Epithelial_cells\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	TXNRD1 LMO7 SEMA3B NQO1 C3	1.09e-04	199	105	5	a212e169cc75b33a560a44eaaaa7c28b86c00246
ToppCell	LPS_anti-TNF-Epithelial_airway-airway_epithelial-Ciliated\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	IQCH ADGB MDH1B B4GALNT3 CFAP44	1.09e-04	199	105	5	15f7814b7074170eee7ccacaa670b1d128fc68bb
ToppCell	Fetal_29-31_weeks-Immune-alveolar_macrophage_(MARCO_positive)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MYO5A MGAT1 PNPLA6 LYN HCK	1.09e-04	199	105	5	22001aa733273e784051b7f750e07d99aaf7a225
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	MAB21L3 LMO7 NQO1 ZNF292 BRWD1	1.09e-04	199	105	5	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	(05)_Secretory-(2)_GFP_FOXI1\|(05)_Secretory / shred by cell type by condition	TXNRD1 MAB21L3 LMO7 NQO1 ZNF292	1.09e-04	199	105	5	d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ELAPOR2 MYO5C MAB21L3 LMO7 C3	1.11e-04	200	105	5	e8db082aa4d0597500e4f16a5c0ea3e62c6c59ae
ToppCell	Hematolymphoid-Microglia-TYROBP----L1-3\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	CPED1 NAV3 C3 LYN HCK	1.11e-04	200	105	5	a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-Ciliated\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	IFT172 ADGB DNAH12 MDH1B CFAP44	1.11e-04	200	105	5	6a2ccc71a0cbe04a542c379b28b5006de53981c3
ToppCell	Hematolymphoid-Microglia-TYROBP--\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	CPED1 NAV3 C3 LYN HCK	1.11e-04	200	105	5	dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCell	Hematolymphoid-Microglia-TYROBP-\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	CPED1 NAV3 C3 LYN HCK	1.11e-04	200	105	5	3bba5219453322198e8fdb0921d5f8c403598751
ToppCell	Hematolymphoid-Microglia\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	CPED1 NAV3 C3 LYN HCK	1.11e-04	200	105	5	21bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCell	Hematolymphoid-Microglia-TYROBP---\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	CPED1 NAV3 C3 LYN HCK	1.11e-04	200	105	5	a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCell	Hematolymphoid-Microglia-TYROBP\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	CPED1 NAV3 C3 LYN HCK	1.11e-04	200	105	5	33036d21c1c82109284473a515c4f890b33fdd5c
ToppCell	(5)_Fibroblast-E\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	ARID4A AOX1 NAV3 C3 CAPN5	1.11e-04	200	105	5	75e5ecb05e965e24d569aa2ef5cdf740b1528c06
ToppCell	mild-unassigned\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ELAPOR2 AFF2 ZBED10P OTOF SYT11	1.11e-04	200	105	5	ca0a08bf162c954f037a56aa0cbb8b5d7c6ffec0
Drug	hMCP	AOX1 NQO1 C3 HCK	2.82e-06	22	104	4	CID006450018
Drug	Cefsulodin sodium salt [52152-93-9]; Down 200; 7.2uM; MCF7; HT_HG-U133A	HFE AOX1 DYSF NEK3 ZNF276 ATM PRLR PRRC2B	3.20e-06	195	104	8	3328_DN
Drug	2-oxoselenazolidine-4-carboxylic acid	TXNRD1 NQO1	2.07e-05	2	104	2	ctd:C476441
Drug	carbazeran	AOX1 ALDH7A1	2.07e-05	2	104	2	CID000071983
Drug	selenaproline	TXNRD1 NQO1	2.07e-05	2	104	2	ctd:C014811
Drug	Cetirizine dihydrochloride [83881-52-1]; Up 200; 8.6uM; MCF7; HT_HG-U133A	HFE SLC17A2 IQCH PACSIN1 DYSF SYT11 ATM	2.99e-05	193	104	7	2829_UP
Drug	Iohexol [66108-95-0]; Up 200; 4.8uM; PC3; HT_HG-U133A	SLC17A2 LMO7 ZNF589 NAV3 ATM INPP5J PRRC2B	3.10e-05	194	104	7	4643_UP
Drug	Glafenine hydrochloride [65513-72-6]; Down 200; 9.8uM; MCF7; HT_HG-U133A	SATB2 RBL2 AOX1 POMGNT1 ATM LYN PRLR	3.20e-05	195	104	7	7018_DN
Drug	Coralyne chloride hydrate [38989-38-7]; Down 200; 9.6uM; MCF7; HT_HG-U133A	HFE AOX1 ZNF589 ATM PRLR INPP5J ALDH7A1	3.30e-05	196	104	7	5418_DN
Drug	Paroxetine maleate [64006-44-6]; Down 200; 1uM; PC3; HT_HG-U133A	RBL2 ZNF276 SBF1 ZNF589 NAV3 ATM CFAP44	3.41e-05	197	104	7	4556_DN
Drug	rosiglitazone; Up 200; 10uM; MCF7; HT_HG-U133A_EA	HFE KANSL1L AFF2 FA2H DYSF ZNF589 PRLR	3.41e-05	197	104	7	1013_UP
Drug	Chlortetracycline hydrochloride [64-72-2]; Up 200; 7.8uM; MCF7; HT_HG-U133A	HFE RBL2 CPED1 ZNF276 ZNF589 CAPN5 ATM	3.41e-05	197	104	7	5360_UP
Drug	Sulfinpyrazone [57-96-5]; Up 200; 9.8uM; MCF7; HT_HG-U133A	CYLD HFE KANSL1L SATB2 SEMA3B ATM INPP5J	3.53e-05	198	104	7	6230_UP
Drug	Biperiden hydrochloride [1235-82-1]; Down 200; 11.4uM; MCF7; HT_HG-U133A	KANSL1L DYSF CPED1 SYT11 C3 PRLR ALDH7A1	3.64e-05	199	104	7	5644_DN
Disease	limb-girdle muscular dystrophy (implicated_via_orthology)	DYSF OTOF FER1L4	1.52e-06	7	105	3	DOID:11724 (implicated_via_orthology)
Disease	rostral middle frontal gyrus volume measurement	ZMYND19 ADGB PLA2R1	1.55e-05	14	105	3	EFO_0010328
Disease	leucine-rich repeat-containing protein 15 measurement	CYP11B2 B4GALNT3	2.60e-04	7	105	2	EFO_0801761
Disease	membranous glomerulonephritis (implicated_via_orthology)	NQO1 C3	4.44e-04	9	105	2	DOID:10976 (implicated_via_orthology)
Disease	Hemolytic-Uremic Syndrome	NQO1 C3	6.76e-04	11	105	2	C0019061
Disease	interleukin-6 measurement, response to stimulus	ELAPOR2 FSTL5	6.76e-04	11	105	2	EFO_0004810, GO_0050896
Disease	Colorectal Carcinoma	SATB2 CCDC9B FSTL5 ETFDH C8orf34 TXNRD1 LMO7 NQO1 ZNF292	9.16e-04	702	105	9	C0009402
Disease	Erythrocyte Mean Corpuscular Hemoglobin Test	HFE ETFDH	9.54e-04	13	105	2	C0369183
Disease	Finding of Mean Corpuscular Hemoglobin	HFE ETFDH	9.54e-04	13	105	2	C1261502
Disease	Spastic Paraplegia, Hereditary	FA2H PNPLA6	1.11e-03	14	105	2	C0037773
Disease	Autosomal recessive limb-girdle muscular dystrophy	POMGNT1 DYSF	1.11e-03	14	105	2	cv:C2931907
Disease	muscular dystrophy (is_implicated_in)	POMGNT1 DYSF	1.65e-03	17	105	2	DOID:9884 (is_implicated_in)
Disease	Liver Cirrhosis, Experimental	SLC17A2 MYO5A RBL2 GPAM EXTL1 DYSF CRY1 HCK PRLR	1.80e-03	774	105	9	C0023893
Disease	advanced glycosylation end product-specific receptor ligand measurement	SLC17A2 B4GALNT3	2.52e-03	21	105	2	EFO_0010762
Disease	Immunologic Deficiency Syndromes	C3 ATM	3.02e-03	23	105	2	C0021051

Protein segments in the cluster

Peptide	Gene	Start	Entry
WREVCESPRKPVAKW	SYT11	411	Q9BT88
WAKWTKEELIGQLKP	CAMTA1	206	Q9Y6Y1
LWEWEEKGISTPRPK	ERVK-18	201	O42043
EWVKADRIIWPLDKG	ARID4A	621	P29374
KPRVWKPGDWSREQL	CPED1	236	A4D0V7
LKWNKPVPWLSEFRG	B4GALNT3	106	Q6L9W6
REAWKIWADIPAPKR	ALDH7A1	96	P49419
KKGKFPLWPEWSEAD	ADGB	41	Q8N7X0
PREDFPDWWQVRKLK	BMX	236	P51813
WPKEVELLLKTWLPG	CARMIL2	21	Q6F5E8
EPPSTNKWQLDKWLN	AFF2	521	P51816
KSLPRSVEHPKWNWR	C8orf34	201	Q49A92
WLWNVEDLKEPPKNG	C3	771	P01024
NKRTWQWLPRDKVLP	BRPF3	1141	Q9ULD4
TCVPPDVWRKYEKWL	AADACL4	271	Q5VUY2
NLPKPVEAFKEWKEW	AMZ2	336	Q86W34
IPDWKEQEWDPEKPN	CAPN5	101	O15484
HVWKVSDLPRQWTPK	CD177	31	Q8N6Q3
IWNWKEEQPILRTKA	CFAP44	256	Q96MT7
EPIISKNPKGTWKDW	AOX1	1111	Q06278
PPLTRILKLWKAWGD	RASSF9	91	O75901
EDWRKKWAQEPALVK	IQCH	691	Q86VS3
HLAWKPESPLWEKIR	RBL2	596	Q08999
DWISKQWGLKNRPEP	TENT4B	426	Q8NDF8
WKRLNPWADKVKVPD	PNPLA6	1181	Q8IY17
KSLWWERRAFPLKGE	KANSL1L	911	A0AUZ9
WLLVKEAQPLEWVKD	LRRC37A3	31	O60309
PQDWPLNEKRTLWKD	MAGEC3	126	Q8TD91
WLLVKEAQPLEWVKD	LRRC37A2	31	A6NM11
WLLVKEAQPLEWVKD	LRRC37A	31	A6NMS7
EKPENDPEWWKCRKI	NCK1	221	P16333
LLAELWAELEPKWPK	MGAT1	271	P26572
WSSELRIPGDELKWK	HERC2	3676	O95714
TKRLWFLWPDDILKN	KIAA1109	1106	Q2LD37
RGWWPVVKLKEAEDV	FER1L4	1646	A9Z1Z3
AQGDWRRPWDLDKAK	CCDC9B	256	Q6ZUT6
LRKPTFDVWLWEPNE	PDE9A	256	O76083
GKRTPWEDPSKWVLD	NAV3	2281	Q8IVL0
DQEIKDKTLPRWQIW	NRDE2	566	Q9H7Z3
EKNPDPTWLQDKSWE	DNAH12	2381	Q6ZR08
LPKCWTPEDVNWKRI	LMO7	421	Q8WWI1
SEDIWKKFELVPPPW	MYCLP1	26	P12525
PEELKPWLVEDWDLV	MORF4L2	126	Q15014
PRKDLWVYKPAQNSW	KBTBD7	401	Q8WVZ9
RAAEPRAWPTKLEWE	HFE	156	Q30201
WNEPKWCIKGISLPE	ELAPOR2	901	A8MWY0
DNPDWVSELKKRAGW	NEK3	486	P51956
VEIPTTWSKKARWPR	MAB21L3	191	Q8N8X9
EGWKKRLENIWDETP	NQO1	206	P15559
SLKEPLKAEEWPWNR	FSTL5	781	Q8N475
FNWIPRRSIWEEAKP	IFT172	266	Q9UG01
GQPAERWKDTWDRVK	SBF1	1666	O95248
TDWAKRWRQLIEKGP	PACSIN1	61	Q9BY11
VVDWDKDLVDWRKPL	FA2H	116	Q7L5A8
KDLVDWRKPLLWQVG	FA2H	121	Q7L5A8
KELWVIDEKNWKPGR	ETFDH	276	Q16134
DPKNLSRLFPGWKAW	ATM	3041	Q13315
KKSRWPFSDECIPWE	ATG101	106	Q9BSB4
LERFWLPPTIKWSDL	CERS3	11	Q8IU89
PQKPWEKDAWEIPRE	HCK	246	P08631
LKKPRVWWELEGPQV	KLHL15	301	Q96M94
VQIPWDKNPEALAKW	CRY1	316	Q16526
WLLPPEKEARAWEAT	HEATR4	191	Q86WZ0
WQWDLESLKFSPRPL	BRWD1	301	Q9NSI6
KITQRPEVWEDWLKD	MDH1B	36	Q5I0G3
PQKPWDKDAWEIPRE	LYN	231	P07948
LKPEDGREDKWVWTR	KLHDC4	271	Q8TBB5
PRSLSRWISPKVWKE	CYP11B2	241	P19099
NPVSLPKDLPDWDWR	CYLD	836	Q9NQC7
VVPWWEKEDPTELDK	GPATCH2	301	Q9NW75
KDLLSQWEIFPPQSW	SLC25A35	191	Q3KQZ1
LPKDDIECPLGWKWE	DYSF	981	O75923
LERKPCIYIKSWWPD	OTOF	706	Q9HC10
EPSWKINPIWKIDTE	RUSC1	226	Q9BVN2
LWKAAKPQEVFWASP	CARS2	231	Q9HA77
AWVRKLKWPELPKFS	SCPEP1	381	Q9HB40
ELEPKWPTPEKLWDW	POMGNT1	461	Q8WZA1
WDKKLPEPLSWRSDE	GPAM	676	Q9HCL2
TPEWVLSWKSKLPLQ	HID1	681	Q8IV36
LRWKENPSPENRTLW	SATB2	521	Q9UPW6
WAKVWPDLPNITIDK	SI	1331	P14410
PRWELPFSEVIDWTK	EXTL1	301	Q92935
LLNIPKDPSSWKNWT	PLA2R1	971	Q13018
WKFDSPERNLWNLKP	STAT5A	631	P42229
EPQDREKGLWWFQLK	CLEC4C	6	Q8WTT0
PAWTDRILWKVKAPG	INPP5J	676	Q15735
FWPLEWTIPSRDNNK	TXNRD1	556	Q16881
LQLVPWGWRPKAEET	ZMYND19	101	Q96E35
KWRRIADPDQPVLWL	TTC13	571	Q8NBP0
KARPLDWRVQSKDWP	TSEN34	196	Q9BSV6
RAKKLAWPAPVEWRE	SEMA3B	86	Q13214
LEIQWWYLKEPPREL	VSTM2B	61	A6NLU5
FTIWAKWAPPLERSK	SLC17A2	166	O00624
EDRKPYLWIKWSPPT	PRLR	141	P16471
PFDPEFWDWKTLKRQ	ZNF292	441	O60281
ALAVKWPWDKETAPR	ZNF276	256	Q8N554
WEKKREAWPPSICLT	ZBED10P	216	Q96FA7
VVKDGRPKWNSWDPR	PRRC2B	396	Q5JSZ5
WWETKLLLPKERRAP	TMDD1	266	P0DPE3
LGLNEDPLKWWSDRL	ZBED1	581	O96006
DPLKWWSDRLALFPL	ZBED1	586	O96006
VSEPEWKKGLPWRAK	ZNF831	1261	Q5JPB2
LPAKDSAWPWEEKPR	ZNF589	16	Q86UQ0
LAVWDENKKRPETWE	ZNF318	1956	Q5VUA4
EWDRKKPLPWRSPLL	ZDHHC1	361	Q8WTX9
GPQVKRADEWKDPWR	ZC3H18	506	Q86VM9
RADEWKDPWRRSKSP	ZC3H18	511	Q86VM9
ARVWIPDPEEVWKSA	MYO5A	11	Q9Y4I1
NRVWIPDPEEVWKSA	MYO5C	11	Q9NQX4
KVLFREPDTWWKFKP	N4BP2	536	Q86UW6
EPDTWWKFKPKELAR	N4BP2	541	Q86UW6