Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glutamate-gated receptor activity	PTK2B GRIK2 GRIN2C GRIN2D	6.34e-07	17	83	4	GO:0004970
GeneOntologyMolecularFunction	NMDA glutamate receptor activity	PTK2B GRIN2C GRIN2D	3.82e-06	8	83	3	GO:0004972
GeneOntologyMolecularFunction	glutamate receptor activity	PTK2B GRIK2 GRIN2C GRIN2D	4.53e-06	27	83	4	GO:0008066
GeneOntologyMolecularFunction	transmitter-gated channel activity	GABRG3 PTK2B GRIK2 GRIN2C GRIN2D	7.46e-06	65	83	5	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	GABRG3 PTK2B GRIK2 GRIN2C GRIN2D	7.46e-06	65	83	5	GO:0022824
GeneOntologyMolecularFunction	extracellular ligand-gated monoatomic ion channel activity	GABRG3 PTK2B GRIK2 GRIN2C GRIN2D	1.72e-05	77	83	5	GO:0005230
GeneOntologyMolecularFunction	neurotransmitter receptor activity	GABRG3 PTK2B GRIK2 GRIN2C GRIN2D	6.07e-05	100	83	5	GO:0030594
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	GABRG3 GRIK2 GRIN2C GRIN2D	9.27e-05	57	83	4	GO:1904315
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	GABRG3 GRIK2 GRIN2C GRIN2D	1.13e-04	60	83	4	GO:0099529
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	GABRG3 GRIK2 GRIN2C GRIN2D	2.69e-04	75	83	4	GO:0098960
GeneOntologyMolecularFunction	glutamate-gated calcium ion channel activity	GRIN2C GRIN2D	4.70e-04	8	83	2	GO:0022849
GeneOntologyMolecularFunction	amino acid transmembrane transporter activity	PTK2B GRIK2 GRIN2C GRIN2D	9.64e-04	105	83	4	GO:0015171
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	GABRG3 PTK2B GRIK2 GRIN2C GRIN2D	1.26e-03	193	83	5	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	GABRG3 PTK2B GRIK2 GRIN2C GRIN2D	1.38e-03	197	83	5	GO:0022834
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	PTK2B ABCB11 GRIK2 GRIN2C GRIN2D	1.72e-03	207	83	5	GO:0046943
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	PTK2B ABCB11 GRIK2 GRIN2C GRIN2D	1.76e-03	208	83	5	GO:0005342
GeneOntologyBiologicalProcess	ionotropic glutamate receptor signaling pathway	PTK2B GRIK2 GRIN2C GRIN2D	3.99e-06	27	83	4	GO:0035235
GeneOntologyBiologicalProcess	modulation of excitatory postsynaptic potential	PTK2B NETO2 GRIK2 GRIN2C GRIN2D	6.38e-06	65	83	5	GO:0098815
GeneOntologyBiologicalProcess	ligand-gated ion channel signaling pathway	PTK2B GRIK2 GRIN2C GRIN2D	1.99e-05	40	83	4	GO:1990806
GeneOntologyBiologicalProcess	positive regulation of excitatory postsynaptic potential	PTK2B NETO2 GRIN2C GRIN2D	2.67e-05	43	83	4	GO:2000463
GeneOntologyBiologicalProcess	actin polymerization or depolymerization	C15orf62 PTK2B ARHGAP6 CORO1A SEMA5A RICTOR PSTPIP2	3.16e-05	222	83	7	GO:0008154
GeneOntologyBiologicalProcess	excitatory chemical synaptic transmission	PTCHD1 GRIN2C GRIN2D	3.39e-05	16	83	3	GO:0098976
GeneOntologyBiologicalProcess	cholesterol metabolic process	MBTPS1 CYP51A1 OSBPL1A ERRFI1 SREBF2 CUBN	5.07e-05	163	83	6	GO:0008203
GeneOntologyBiologicalProcess	protein lipidation	PIGN PIGT SLC30A5 ZDHHC6 UGCG	5.47e-05	101	83	5	GO:0006497
GeneOntologyBiologicalProcess	lipoprotein biosynthetic process	PIGN PIGT SLC30A5 ZDHHC6 UGCG	6.88e-05	106	83	5	GO:0042158
GeneOntologyBiologicalProcess	regulation of nervous system process	PTK2B NETO2 SREBF2 GRIK2 GRIN2C GRIN2D	7.53e-05	175	83	6	GO:0031644
GeneOntologyBiologicalProcess	secondary alcohol metabolic process	MBTPS1 CYP51A1 OSBPL1A ERRFI1 SREBF2 CUBN	7.77e-05	176	83	6	GO:1902652
GeneOntologyBiologicalProcess	sterol metabolic process	MBTPS1 CYP51A1 OSBPL1A ERRFI1 SREBF2 CUBN	8.01e-05	177	83	6	GO:0016125
GeneOntologyBiologicalProcess	regulation of postsynaptic membrane potential	GABRG3 PTK2B NETO2 GRIK2 GRIN2C GRIN2D	8.79e-05	180	83	6	GO:0060078
GeneOntologyBiologicalProcess	glutamate receptor signaling pathway	PTK2B GRIK2 GRIN2C GRIN2D	9.37e-05	59	83	4	GO:0007215
GeneOntologyBiologicalProcess	actin filament polymerization	C15orf62 PTK2B ARHGAP6 CORO1A RICTOR PSTPIP2	1.18e-04	190	83	6	GO:0030041
GeneOntologyBiologicalProcess	steroid metabolic process	MBTPS1 CYP51A1 OSBPL1A ERRFI1 SREBF2 ABCB11 CUBN STAT5B	1.36e-04	376	83	8	GO:0008202
GeneOntologyBiologicalProcess	excitatory postsynaptic potential	PTK2B NETO2 GRIK2 GRIN2C GRIN2D	1.80e-04	130	83	5	GO:0060079
GeneOntologyBiologicalProcess	steroid biosynthetic process	MBTPS1 CYP51A1 OSBPL1A ERRFI1 SREBF2 ABCB11	1.99e-04	209	83	6	GO:0006694
GeneOntologyBiologicalProcess	actin filament organization	C15orf62 PTK2B ARHGAP6 CORO1A MYO1A CARMIL3 SEMA5A RICTOR PSTPIP2	2.06e-04	509	83	9	GO:0007015
GeneOntologyBiologicalProcess	regulation of actin filament organization	C15orf62 PTK2B ARHGAP6 CORO1A CARMIL3 SEMA5A RICTOR	2.07e-04	300	83	7	GO:0110053
GeneOntologyBiologicalProcess	GPI anchor biosynthetic process	PIGN PIGT SLC30A5	3.14e-04	33	83	3	GO:0006506
GeneOntologyBiologicalProcess	chemical synaptic transmission, postsynaptic	PTK2B NETO2 GRIK2 GRIN2C GRIN2D	3.19e-04	147	83	5	GO:0099565
GeneOntologyBiologicalProcess	lipoprotein metabolic process	PIGN PIGT SLC30A5 ZDHHC6 UGCG	3.19e-04	147	83	5	GO:0042157
GeneOntologyBiologicalProcess	glycolipid biosynthetic process	PIGN PIGT SLC30A5 UGCG	3.20e-04	81	83	4	GO:0009247
GeneOntologyBiologicalProcess	GPI anchor metabolic process	PIGN PIGT SLC30A5	3.75e-04	35	83	3	GO:0006505
GeneOntologyBiologicalProcess	regulation of synaptic transmission, glutamatergic	PTK2B GRIK2 GRIN2C GRIN2D	5.20e-04	92	83	4	GO:0051966
GeneOntologyBiologicalProcess	bile acid biosynthetic process	OSBPL1A ERRFI1 ABCB11	5.58e-04	40	83	3	GO:0006699
GeneOntologyBiologicalProcess	protein insertion into mitochondrial membrane	TOMM22 COX18	5.65e-04	9	83	2	GO:0051204
GeneOntologyBiologicalProcess	positive regulation of synaptic transmission, glutamatergic	PTK2B GRIN2C GRIN2D	6.90e-04	43	83	3	GO:0051968
GeneOntologyBiologicalProcess	regulation of actin polymerization or depolymerization	C15orf62 PTK2B CORO1A SEMA5A RICTOR	7.44e-04	177	83	5	GO:0008064
GeneOntologyBiologicalProcess	regulation of actin filament length	C15orf62 PTK2B CORO1A SEMA5A RICTOR	8.02e-04	180	83	5	GO:0030832
GeneOntologyCellularComponent	NMDA selective glutamate receptor complex	PTK2B GRIN2C GRIN2D	4.80e-06	9	82	3	GO:0017146
GeneOntologyCellularComponent	ionotropic glutamate receptor complex	PTK2B GRIK2 GRIN2C GRIN2D	2.90e-05	45	82	4	GO:0008328
GeneOntologyCellularComponent	neurotransmitter receptor complex	PTK2B GRIK2 GRIN2C GRIN2D	4.41e-05	50	82	4	GO:0098878
MousePheno	fused cornea and lens	AGAP5 UBE3B AGAP9 CUBN	4.76e-06	24	67	4	MP:0001307
Domain	Iontro_rcpt	GRIK2 GRIN2C GRIN2D	5.47e-05	18	78	3	IPR001320
Domain	Lig_chan-Glu_bd	GRIK2 GRIN2C GRIN2D	5.47e-05	18	78	3	PF10613
Domain	Iono_rcpt_met	GRIK2 GRIN2C GRIN2D	5.47e-05	18	78	3	IPR001508
Domain	Glu/Gly-bd	GRIK2 GRIN2C GRIN2D	5.47e-05	18	78	3	IPR019594
Domain	Lig_chan-Glu_bd	GRIK2 GRIN2C GRIN2D	5.47e-05	18	78	3	SM00918
Domain	Lig_chan	GRIK2 GRIN2C GRIN2D	5.47e-05	18	78	3	PF00060
Domain	PBPe	GRIK2 GRIN2C GRIN2D	5.47e-05	18	78	3	SM00079
Domain	Pyridine_nuc-diS_OxRdtase_2	DPYD AIFM2	1.03e-04	4	78	2	IPR000103
Domain	ArfGap	AGAP5 ADAP1 AGAP9	2.37e-04	29	78	3	SM00105
Domain	ArfGap	AGAP5 ADAP1 AGAP9	2.37e-04	29	78	3	PF01412
Domain	ARFGAP	AGAP5 ADAP1 AGAP9	2.37e-04	29	78	3	PS50115
Domain	ArfGAP	AGAP5 ADAP1 AGAP9	2.37e-04	29	78	3	IPR001164
Domain	ANF_lig-bd_rcpt	GRIK2 GRIN2C GRIN2D	4.92e-04	37	78	3	IPR001828
Domain	ANF_receptor	GRIK2 GRIN2C GRIN2D	4.92e-04	37	78	3	PF01094
Domain	Peripla_BP_I	GRIK2 GRIN2C GRIN2D	5.75e-04	39	78	3	IPR028082
Domain	IBN_N	IPO9 XPO5	1.99e-03	16	78	2	SM00913
Domain	PH_dom-like	PTK2B AGAP5 ADAP1 NBEAL1 OSBPL1A AGAP9 TEC	2.01e-03	426	78	7	IPR011993
Domain	Importin-beta_N	IPO9 XPO5	2.25e-03	17	78	2	IPR001494
Domain	Pyr_redox_2	DPYD AIFM2	2.81e-03	19	78	2	PF07992
Domain	PH	AGAP5 ADAP1 OSBPL1A AGAP9 TEC	6.15e-03	278	78	5	SM00233
Domain	PH_DOMAIN	AGAP5 ADAP1 OSBPL1A AGAP9 TEC	6.24e-03	279	78	5	PS50003
Domain	PH_domain	AGAP5 ADAP1 OSBPL1A AGAP9 TEC	6.33e-03	280	78	5	IPR001849
Pathway	REACTOME_METABOLISM_OF_STEROIDS	MBTPS1 CYP51A1 OSBPL1A SREBF2 ABCB11 CUBN	3.53e-05	154	57	6	M27832
Pathway	REACTOME_METABOLISM_OF_STEROIDS	MBTPS1 CYP51A1 OSBPL1A SREBF2 ABCB11	1.52e-04	126	57	5	MM15553
Pathway	KEGG_MEDICUS_REFERENCE_TRANSPORT_OF_CALCIUM	GRIN2C GRIN2D	1.59e-04	5	57	2	M47667
Pathway	REACTOME_ASSEMBLY_AND_CELL_SURFACE_PRESENTATION_OF_NMDA_RECEPTORS	GRIN2C GRIN2D	1.59e-04	5	57	2	MM15655
Pathway	BIOCARTA_S1P_PATHWAY	MBTPS1 SREBF2	2.38e-04	6	57	2	MM1556
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PDYN_TO_TRANSPORT_OF_CALCIUM	GRIN2C GRIN2D	2.38e-04	6	57	2	M47668
Pathway	REACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF	MBTPS1 SREBF2	3.33e-04	7	57	2	MM14639
Pathway	BIOCARTA_S1P_PATHWAY	MBTPS1 SREBF2	4.43e-04	8	57	2	M22036
Pubmed	In the Telencephalon, GluN2C NMDA Receptor Subunit mRNA is Predominately Expressed in Glial Cells and GluN2D mRNA in Interneurons.	GRIN2C GRIN2D	6.04e-06	2	86	2	29651654
Pubmed	Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes.	GRIN2C GRIN2D	6.04e-06	2	86	2	31110197
Pubmed	Kainate receptor modulation by NETO2.	NETO2 GRIK2	6.04e-06	2	86	2	34552241
Pubmed	Enhanced function of NR2C/2D-containing NMDA receptor in the nucleus accumbens contributes to peripheral nerve injury-induced neuropathic pain and depression in mice.	GRIN2C GRIN2D	6.04e-06	2	86	2	35057644
Pubmed	NMDA receptors containing GluN2C and GluN2D subunits have opposing roles in modulating neuronal oscillations; potential mechanism for bidirectional feedback.	GRIN2C GRIN2D	6.04e-06	2	86	2	31786200
Pubmed	Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2.	MBTPS1 SREBF2	6.04e-06	2	86	2	9139737
Pubmed	Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility.	GRIN2C GRIN2D	6.04e-06	2	86	2	29317596
Pubmed	A transmembrane accessory subunit that modulates kainate-type glutamate receptors.	NETO2 GRIK2	6.04e-06	2	86	2	19217376
Pubmed	NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice.	GRIN2C GRIN2D	6.04e-06	2	86	2	33766086
Pubmed	Auditory pathway and auditory brainstem response in mice lacking NMDA receptor epsilon 1 and epsilon 4 subunits.	GRIN2C GRIN2D	1.81e-05	3	86	2	9718984
Pubmed	Cocaine preference and neuroadaptations are maintained by astrocytic NMDA receptors in the nucleus accumbens.	GRIN2C GRIN2D	1.81e-05	3	86	2	35867797
Pubmed	Facilitation of GluN2C-containing NMDA receptors in the external globus pallidus increases firing of fast spiking neurons and improves motor function in a hemiparkinsonian mouse model.	GRIN2C GRIN2D	1.81e-05	3	86	2	33421565
Pubmed	Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi.	MBTPS1 SREBF2	1.81e-05	3	86	2	10619424
Pubmed	Mitochondrial translation failure represses cholesterol gene expression via Pyk2-Gsk3β-Srebp2 axis.	PTK2B SREBF2	1.81e-05	3	86	2	38719751
Pubmed	Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels.	GRIN2C GRIN2D	1.81e-05	3	86	2	9480759
Pubmed	Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization.	MBTPS1 SREBF2	1.81e-05	3	86	2	9990022
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRIK2 GRIN2C GRIN2D	2.85e-05	24	86	3	35746896
Pubmed	The auxiliary subunits Neto1 and Neto2 have distinct, subunit-dependent effects at recombinant GluK1- and GluK2-containing kainate receptors.	NETO2 GRIK2	3.61e-05	4	86	2	26277340
Pubmed	Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase.	PTK2B TEC	3.61e-05	4	86	2	10518561
Pubmed	FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2α at the CYP51 promoter.	CYP51A1 SREBF2	3.61e-05	4	86	2	24353279
Pubmed	Functional correlation of NMDA receptor epsilon subunits expression with the properties of single-channel and synaptic currents in the developing cerebellum.	GRIN2C GRIN2D	3.61e-05	4	86	2	8699248
Pubmed	The cytoplasmic tyrosine kinase Pyk2 as a novel effector of fibroblast growth factor receptor 3 activation.	PTK2B STAT5B	3.61e-05	4	86	2	15105428
Pubmed	Analysis of exome data for 4293 trios suggests GPI-anchor biogenesis defects are a rare cause of developmental disorders.	PIGN PIGT	3.61e-05	4	86	2	28327575
Pubmed	Role of the carboxy-terminal region of the GluR epsilon2 subunit in synaptic localization of the NMDA receptor channel.	GRIN2C GRIN2D	3.61e-05	4	86	2	9768843
Pubmed	Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.	GRIN2C GRIN2D	3.61e-05	4	86	2	36309015
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	PIGT SLC30A5 NETO2 SYNE2 CYP51A1 OSBPL1A SREBF2 B9D1	3.63e-05	504	86	8	34432599
Pubmed	Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.	GABRG3 GRIK2 GRIN2C GRIN2D	5.01e-05	81	86	4	22723691
Pubmed	Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs.	PIGT UBE3B MAGT1	5.65e-05	30	86	3	11483580
Pubmed	Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.	GRIN2C GRIN2D	6.01e-05	5	86	2	26919761
Pubmed	Distinct distributions of five NMDA receptor channel subunit mRNAs in the brainstem.	GRIN2C GRIN2D	6.01e-05	5	86	2	7518475
Pubmed	Distinct spatiotemporal expressions of five NMDA receptor channel subunit mRNAs in the cerebellum.	GRIN2C GRIN2D	6.01e-05	5	86	2	7518474
Pubmed	Synapse-selective impairment of NMDA receptor functions in mice lacking NMDA receptor epsilon 1 or epsilon 2 subunit.	GRIN2C GRIN2D	6.01e-05	5	86	2	9147327
Pubmed	Neurotransmission and bipolar disorder: a systematic family-based association study.	GRIN2C GRIN2D	6.01e-05	5	86	2	18444252
Pubmed	Distinct gene expression of the N-methyl-D-aspartate receptor channel subunit in peripheral neurons of the mouse sensory ganglia and adrenal gland.	GRIN2C GRIN2D	6.01e-05	5	86	2	8015722
Pubmed	Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain.	GRIN2C GRIN2D	6.01e-05	5	86	2	15003177
Pubmed	GABAA, GABAC, and NMDA receptor subunit expression in the suprachiasmatic nucleus and other brain regions.	GRIN2C GRIN2D	6.01e-05	5	86	2	7723623
Pubmed	Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor.	GRIN2C GRIN2D	6.01e-05	5	86	2	12082569
Pubmed	Heterozygous deletion of NR1 subunit of the NMDA receptor alters ethanol-related behaviors and regional expression of NR2 subunits in the brain.	GRIN2C GRIN2D	6.01e-05	5	86	2	21945132
Pubmed	Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages.	MBTPS1 SREBF2	6.01e-05	5	86	2	30366764
Pubmed	Roles of the glutamate receptor epsilon2 and delta2 subunits in the potentiation and prepulse inhibition of the acoustic startle reflex.	GRIN2C GRIN2D	6.01e-05	5	86	2	11488959
Pubmed	Developmental changes in distribution of NMDA receptor channel subunit mRNAs.	GRIN2C GRIN2D	6.01e-05	5	86	2	1493227
Pubmed	N-methyl-D-aspartic acid receptor structure and function.	GRIN2C GRIN2D	6.01e-05	5	86	2	8036251
Pubmed	NMDA receptor activation by HIV-Tat protein is clade dependent.	GRIN2C GRIN2D	6.01e-05	5	86	2	19020013
Pubmed	Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.	ABCB11 GCKR	6.01e-05	5	86	2	19937311
Pubmed	Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.	GRIN2C GRIN2D	6.01e-05	5	86	2	26875626
Pubmed	Differential distributions of the NMDA receptor channel subunit mRNAs in the mouse retina.	GRIN2C GRIN2D	6.01e-05	5	86	2	7510577
Pubmed	Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene.	GRIN2C GRIN2D	6.01e-05	5	86	2	8756432
Pubmed	Neto Auxiliary Subunits Regulate Interneuron Somatodendritic and Presynaptic Kainate Receptors to Control Network Inhibition.	NETO2 GRIK2	6.01e-05	5	86	2	28854365
Pubmed	Differential interaction of NMDA receptor subtypes with the post-synaptic density-95 family of membrane associated guanylate kinase proteins.	GRIN2C GRIN2D	6.01e-05	5	86	2	18233995
Pubmed	Distinct spatiotemporal distributions of the N-methyl-D-aspartate receptor channel subunit mRNAs in the mouse cervical cord.	GRIN2C GRIN2D	6.01e-05	5	86	2	7929904
Pubmed	The layered structure of human mitochondrial DNA nucleoids.	DBT TOP1MT DHX30	6.87e-05	32	86	3	18063578
Pubmed	A role for spermine oxidase as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity.	GRIN2C GRIN2D	9.01e-05	6	86	2	23665428
Pubmed	Altered gene expression of the N-methyl-D-aspartate receptor channel subunits in Purkinje cells of the staggerer mutant mouse.	GRIN2C GRIN2D	9.01e-05	6	86	2	8996814
Pubmed	NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit.	GRIN2C GRIN2D	9.01e-05	6	86	2	15317856
Pubmed	Neto1 is an auxiliary subunit of native synaptic kainate receptors.	NETO2 GRIK2	9.01e-05	6	86	2	21734292
Pubmed	Cortical consequences of HIV-1 Tat exposure in rats are enhanced by chronic cocaine.	GRIN2C GRIN2D	9.01e-05	6	86	2	25760043
Pubmed	Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo.	GRIN2C GRIN2D	9.01e-05	6	86	2	9458051
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	MBTPS1 DCAF13 SLC30A5 TOMM22 NETO2 TMEM87B CYP51A1 SREBF2 MAGT1 DHX30	1.22e-04	952	86	10	38569033
Pubmed	HIV immune complexes prevent excitotoxicity by interaction with NMDA receptors.	GRIN2C GRIN2D	1.26e-04	7	86	2	22940423
Pubmed	Early onset of NMDA receptor GluR epsilon 1 (NR2A) expression and its abundant postsynaptic localization in developing motoneurons of the mouse hypoglossal nucleus.	GRIN2C GRIN2D	1.26e-04	7	86	2	12103442
Pubmed	Human immunodeficiency virus-1 protein Tat induces excitotoxic loss of presynaptic terminals in hippocampal cultures.	GRIN2C GRIN2D	1.26e-04	7	86	2	23267846
Pubmed	Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell death.	GRIN2C GRIN2D	1.26e-04	7	86	2	19036954
Pubmed	Mediation by the protein-tyrosine kinase Tec of signaling between the B cell antigen receptor and Dok-1.	PTK2B TEC	1.26e-04	7	86	2	10823839
Pubmed	Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.	GRIN2C GRIN2D	1.26e-04	7	86	2	22833210
Pubmed	Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons.	GRIN2C GRIN2D	1.68e-04	8	86	2	8804048
Pubmed	The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid.	GRIN2C GRIN2D	1.68e-04	8	86	2	8845955
Pubmed	HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons.	GRIN2C GRIN2D	1.68e-04	8	86	2	8563977
Pubmed	HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures.	GRIN2C GRIN2D	1.68e-04	8	86	2	8821747
Pubmed	Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity.	GRIN2C GRIN2D	1.68e-04	8	86	2	7695237
Pubmed	HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes.	GRIN2C GRIN2D	1.68e-04	8	86	2	17360663
Pubmed	Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120.	GRIN2C GRIN2D	1.68e-04	8	86	2	8724036
Pubmed	Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine.	GRIN2C GRIN2D	1.68e-04	8	86	2	8822372
Pubmed	Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production.	GRIN2C GRIN2D	1.68e-04	8	86	2	21106831
Pubmed	Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical cultures.	GRIN2C GRIN2D	1.68e-04	8	86	2	10448428
Pubmed	Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase.	GRIN2C GRIN2D	1.68e-04	8	86	2	8955056
Pubmed	Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system.	GRIN2C GRIN2D	1.68e-04	8	86	2	10555109
Pubmed	Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations.	RICTOR STAT5B	1.68e-04	8	86	2	27879203
Pubmed	Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.	IPO9 PSME4 XPO5 POLE TRMT1L	1.83e-04	211	86	5	17314511
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	AIFM2 SLC30A5 PSME4 POLE UBE3B SREBF2 RICTOR STAT5B	2.10e-04	650	86	8	38777146
Pubmed	GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.	AGAP5 AGAP9	2.15e-04	9	86	2	12640130
Pubmed	D1/NMDA receptors and concurrent methamphetamine+ HIV-1 Tat neurotoxicity.	GRIN2C GRIN2D	2.15e-04	9	86	2	22552781
Pubmed	Activation of cannabinoid type 2 receptors inhibits HIV-1 envelope glycoprotein gp120-induced synapse loss.	GRIN2C GRIN2D	2.15e-04	9	86	2	21670103
Pubmed	PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A.	GRIN2C GRIN2D	2.15e-04	9	86	2	9892651
Pubmed	Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems.	GRIN2C GRIN2D	2.15e-04	9	86	2	17526495
Pubmed	Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data.	GRIK2 GRIN2C	2.15e-04	9	86	2	34100982
Pubmed	Human immunodeficiency virus type 1 clade B and C gp120 differentially induce neurotoxin arachidonic acid in human astrocytes: implications for neuroAIDS.	GRIN2C GRIN2D	2.15e-04	9	86	2	21491143
Pubmed	Maternal stress produces learning deficits associated with impairment of NMDA receptor-mediated synaptic plasticity.	GRIN2C GRIN2D	2.15e-04	9	86	2	16554481
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	PSME4 TMEM42 COX6A1 UGCG ERRFI1 CPA1 RICTOR GRIN2C TEX11	2.18e-04	832	86	9	36724073
Pubmed	Substrate-trapping techniques in the identification of cellular PTP targets.	PTK2B TEC STAT5B	2.48e-04	49	86	3	15588985
Pubmed	N-methyl-D-aspartate receptors mediate the phosphorylation and desensitization of muscarinic receptors in cerebellar granule neurons.	GRIN2C GRIN2D	2.68e-04	10	86	2	19332541
Pubmed	AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.	AGAP5 AGAP9	2.68e-04	10	86	2	20664521
Pubmed	AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.	AGAP5 AGAP9	3.28e-04	11	86	2	15381706
Pubmed	Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase.	GRIN2C GRIN2D	3.28e-04	11	86	2	8581564
Pubmed	HIV-1 Tat-mediated apoptosis in human blood-retinal barrier-associated cells.	GRIN2C GRIN2D	3.28e-04	11	86	2	24739951
Pubmed	CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins.	GRIN2C GRIN2D	3.28e-04	11	86	2	9647694
Pubmed	Effects of SDF-1alpha and gp120IIIB on apoptotic pathways in SK-N-SH neuroblastoma cells.	GRIN2C GRIN2D	3.28e-04	11	86	2	16481105
Pubmed	Developmental rearrangements of cortical glutamate-NMDA receptor binding sites in late human gestation.	GRIN2C GRIN2D	3.93e-04	12	86	2	8665664
Pubmed	Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle.	GRIN2C GRIN2D	3.93e-04	12	86	2	12815021
Pubmed	Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102.	GRIN2C GRIN2D	3.93e-04	12	86	2	11937501
Pubmed	Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.	MBTPS1 CYP51A1 SREBF2 ABCB11 STAT5B	4.00e-04	250	86	5	18660489
Interaction	CHRNB2 interactions	NETO2 TMEM87B DIPK1A SREBF2 ADGRL1 MAGT1	3.40e-06	103	80	6	int:CHRNB2
GeneFamily	ArfGAPs	AGAP5 ADAP1 AGAP9	1.52e-04	33	57	3	395
GeneFamily	Glutamate ionotropic receptor NMDA type subunits	GRIN2C GRIN2D	2.03e-04	7	57	2	1201
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	AGAP5 AGAP9	1.29e-03	17	57	2	1291
GeneFamily	Glycosyl transferases group 1 domain containing\|Phosphatidylinositol glycan anchor biosynthesis	PIGN PIGT	1.97e-03	21	57	2	680
GeneFamily	DNA polymerases	POLE DNTT	2.37e-03	23	57	2	535
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	AGAP5 ADAP1 AGAP9 TEC	4.04e-03	206	57	4	682
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c2-CXCR4(low)\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	DPYD DIPK1A GCKR TOP1MT DCUN1D3 TEC	2.21e-07	132	86	6	a1fda8c5287168c4f159203ed27cadfb4ce1b131
Disease	Multiple congenital anomalies-hypotonia-seizures syndrome	PIGN PIGT	4.45e-05	4	81	2	cv:C5191419
Disease	tyrosine-protein kinase TEC measurement	TEC TEC	4.45e-05	4	81	2	EFO_0020830
Disease	fasting blood glucose measurement, glucose tolerance test, fasting blood insulin measurement	ABCB11 GCKR	7.40e-05	5	81	2	EFO_0004307, EFO_0004465, EFO_0004466
Disease	prostate cancer (implicated_via_orthology)	POLE CYP51A1 MAGT1	1.02e-04	33	81	3	DOID:10283 (implicated_via_orthology)
Disease	Combined immunodeficiency	CORO1A MAGT1 STAT5B	1.97e-04	41	81	3	C0494261
Disease	endometrial cancer (implicated_via_orthology)	POLE ERRFI1	2.06e-04	8	81	2	DOID:1380 (implicated_via_orthology)
Disease	cerebral palsy (implicated_via_orthology)	AGAP5 AGAP9	3.30e-04	10	81	2	DOID:1969 (implicated_via_orthology)
Disease	level of Ceramide (d40:1) in blood serum	SYNE2 GCKR	4.03e-04	11	81	2	OBA_2045185
Disease	cystathionine measurement	TEC TEC	1.23e-03	19	81	2	EFO_0010474
Disease	colorectal adenocarcinoma (is_marker_for)	RICTOR STAT5B	2.50e-03	27	81	2	DOID:0050861 (is_marker_for)
Disease	triglycerides:total lipids ratio, high density lipoprotein cholesterol measurement	PIGT SYNE2 GCKR STAT5B	2.52e-03	206	81	4	EFO_0004612, EFO_0020947
Disease	amino acid measurement	PIGN GABRG3 CCNT2 SEMA5A GRIK2 GCKR PEBP4	2.62e-03	678	81	7	EFO_0005134
Disease	attention deficit hyperactivity disorder (implicated_via_orthology)	PTCHD1 ADGRL1	2.69e-03	28	81	2	DOID:1094 (implicated_via_orthology)
Disease	lung small cell carcinoma (is_implicated_in)	XPO5 RICTOR	2.69e-03	28	81	2	DOID:5409 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LSSQESFSKMRTGWR	LINC00114	16	Q6XXX2
MASGRGASSRWFFTR	CCNT2	1	O60583
WIFMSFALRNLSTGA	COX18	181	Q8N8Q8
RSMRWSNLFTSEKGS	AGAP9	291	Q5VTM2
RMWNDTVRKQTESSF	ADGRL1	1151	O94910
FAFTHSTNRMWRKTR	CPA1	226	P15085
DRFSFRSFRSGMWLS	GSG1	86	Q2KHT4
FRFSSSTDIWLMFVG	ABCB11	51	O95342
STSMIRRAFEAGWGF	DPYD	556	Q12882
QTEGFRKRWFTMDDR	ADAP1	266	O75689
QSSRSNRFTWMGLSD	CD209	306	Q9NNX6
TTGFSRMSERQVALW	CORO1A	236	P31146
GSRMRKLWLTYSSQT	FBXL6	271	Q8N531
SRWLTYFMAVKSNGS	DHX30	1071	Q7L2E3
KGISRDTWNMFLNFT	DCUN1D3	236	Q8IWE4
SMTWGFDSISSVKFN	DCAF13	191	Q9NV06
KNREWMLIRTSSFTF	ARNT2	406	Q9HBZ2
EMRSGQLSRKFWGSS	NBEAL1	2661	Q6ZS30
MTRSLFKGNFWSADI	PSTPIP2	1	Q9H939
SDVFSSKGMTRWGEF	RASSF6	121	Q6ZTQ3
DGATMSRFSNLWKSY	DBT	456	P11182
RRSNMEFLFNKTGWA	MAGT1	206	Q9H0U3
NIARFSSRGMTTWEL	MBTPS1	366	Q14703
RFRTVNSTSWMEVNF	IL31RA	161	Q8NI17
RKSQILISSWFRGNM	MYO1A	721	Q9UBC5
SWTQFRQDTGTMRAV	DTX2	81	Q86UW9
FSLSTSGMRVSWIRQ	IGHV2-70D	46	A0A0C4DH43
STWQKSRGDRTYSSM	ATXN8OS	166	P0DMR3
FSLSNARMGVSWIRQ	IGHV2-26	46	A0A0B4J1V2
TKPSFSAMRRAEATW	CARMIL3	1211	Q8ND23
MNSRTASARGWFSSR	C3orf18	1	Q9UK00
TRGSWKMDRFLNRFH	PEBP4	171	Q96S96
ERSQWTDKMDLRFGF	POLE	36	Q07864
EEGSARMWKTLTFFV	COX6A1	31	P12074
RRSSVNFVKWSSQGM	HSPA12B	431	Q96MM6
MFSRNDFSIWSILRK	OSBPL1A	541	Q9BXW6
FLASKMGIIATFRSW	RICTOR	281	Q6R327
FWRALAMLQRFSGQS	GCKR	516	Q14397
EGDFTWNSMSGRSVR	ARHGAP6	196	O43182
MLGRNTWKTSAFSFL	CA5A	1	P35218
SFQTAKGWKMSFRQT	CUBN	3136	O60494
TWTDSRLRFNSTMKI	GABRG3	101	Q99928
TWFQRSQESLARKMA	CCDC191	786	Q8NCU4
TSSTTSAWMGFFLAR	CYP51A1	321	Q16850
SAWMGFFLARDKTLQ	CYP51A1	326	Q16850
KAIADRGWRFAMSTQ	UGCG	241	Q16739
GRALWAASRFTVAMS	IPO9	496	Q96P70
WMSPESINFRRFTTA	PTK2B	591	Q14289
SINFRRFTTASDVWM	PTK2B	596	Q14289
WAFMSSRRQSVLVKS	GRIK2	706	Q13002
STSKLQKFTSWFMGR	B9D1	126	Q9UPM9
SGFRRSMDQLFTPSW	DIPK1A	251	Q5T7M9
SLVMGVTSESWRSFF	SAA4	11	P35542
WSSSLFNTGFLKRML	TRMT1L	531	Q7Z2T5
KSQFWRMVALSTSRL	QTRT1	236	Q9BXR0
FKSSWRNGMAFLAII	SYNE2	206	Q8WXH0
KTSEKWFRMGFRTLS	DNTT	261	P04053
RFSSKSDVWSFGVLM	TEC	541	P42680
SRDLFVSTSWKTMRQ	AIFM2	356	Q9BRQ8
RWSKSGMNFTVGSNF	RGS22	151	Q8NE09
LYGTFEMLSSWRKTR	PTCHD1	341	Q96NR3
WNLMPFTTRDFSIRS	STAT5B	641	P51692
RSTGRFMWIKFSSDE	NETO2	131	Q8NC67
MGNMRKTYWSSRSEF	ERRFI1	26	Q9UJM3
RFLLEDTWTTFMKAR	SEMA5A	261	Q13591
GSFITLRSRWFSFMN	ARNTL	411	O00327
RSMRWSNLFTSEKGS	AGAP5	246	A6NIR3
METWRKGSFRNASFF	C15orf62	1	A8K5M9
SSLRGTFGTRWEAMK	C10orf67	26	Q8IYJ2
FGWNTVKIDMSAARR	ZDHHC6	176	Q9H6R6
TGQGKKDWSLFRMFS	PIGT	251	Q969N2
KDWSLFRMFSRTLTE	PIGT	256	Q969N2
GQKFFMERSWSVKSA	SREBF2	766	Q12772
SKTQRERFAWALAMA	TOP1MT	581	Q969P6
FLRSSTQMTWGALFR	XPO5	366	Q9HAV4
WNTGVLMFSRSKYAS	TEX11	871	Q8IYF3
TMSFQGTWRKRFSST	SERPINE3	191	A8MV23
TRAKMTSLSWTFFSL	PIGN	586	O95427
TILKWLMASAGRSFS	PSME4	1576	Q14997
KMYRFSRAALWIGTT	TOMM22	76	Q9NS69
SIVFMGWTTKTFRIA	TMEM87B	406	Q96K49
MFTLSQTSRAWFIDR	UBE3B	1	Q7Z3V4
QKWGMTIRFDSSFSR	ZNF22	31	P17026
ALMSRWKATRIFSYG	SLC30A5	466	Q8TAD4
NSLMWTFFSRGLSFS	TMEM42	81	Q69YG0
QRMDWLTSKSRQIFG	VWA3B	121	Q502W6
MSTNNALRVFWKSRE	PP2D1	1	A8MPX8
RGTTSKIMVLVWAFF	GRIN2C	621	Q14957
RGTTSKIMVLVWAFF	GRIN2D	651	O15399