Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent activity	PMS2 ATP6V1E2 PEX1 KIF4A RAD54L2 ABCA9 DNAH1 DHX15 DNAH17 SHPRH KIF4B KIF5A ASCC3 YME1L1 ATP4B SLC27A5 KIF22 DNAH11	7.82e-07	614	149	18	GO:0140657
GeneOntologyMolecularFunction	microtubule motor activity	KIF4A DNAH1 DNAH17 KIF4B KIF5A KIF22 DNAH11	9.05e-07	70	149	7	GO:0003777
GeneOntologyMolecularFunction	cytoskeletal motor activity	KIF4A DNAH1 DNAH17 KIF4B KIF5A KIF22 DNAH11	2.95e-05	118	149	7	GO:0003774
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH1 DNAH17 DNAH11	3.06e-04	18	149	3	GO:0008569
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	PMS2 ERN1 MUS81 DCLRE1B RAD54L2 OGG1 YARS1 GGT1 GGT3P DHX15 SHPRH MARF1 ASCC3 PIWIL3	3.44e-04	645	149	14	GO:0140640
GeneOntologyMolecularFunction	nuclease activity	PMS2 ERN1 ENPP1 MUS81 DCLRE1B OGG1 MARF1 PIWIL3	3.49e-04	231	149	8	GO:0004518
GeneOntologyCellularComponent	microtubule associated complex	KIF4A RABGAP1 DNAH1 DNAH17 KIF4B KIF5A KIF22 DNAH11	2.62e-05	161	154	8	GO:0005875
GeneOntologyCellularComponent	cytoplasmic region	NUMA1 KIF4A TEKT5 DNAH1 AGBL4 CFAP54 BBS7 DNAH17 KIF5A CFAP46 DNAH11	7.60e-05	360	154	11	GO:0099568
GeneOntologyCellularComponent	apical dendrite	ENPP1 HCN1 PTK2B KIF5A	8.67e-05	32	154	4	GO:0097440
GeneOntologyCellularComponent	plasma membrane bounded cell projection cytoplasm	KIF4A TEKT5 DNAH1 AGBL4 CFAP54 BBS7 DNAH17 KIF5A CFAP46 DNAH11	1.25e-04	317	154	10	GO:0032838
GeneOntologyCellularComponent	HCN channel complex	HCN4 HCN1	3.20e-04	4	154	2	GO:0098855
Domain	P-loop_NTPase	RRAS2 SAMD9 PEX1 CHST6 KIF4A CARD10 RAD54L2 ARHGAP35 ABCA9 DNAH1 SULT1E1 DHX15 NWD2 DGUOK SHPRH KIF4B KIF5A ASCC3 YME1L1 KIF22 DNAH11	5.33e-06	848	152	21	IPR027417
Domain	Grip	RGPD8 RGPD1 RGPD5	8.31e-05	11	152	3	SM00755
Domain	GRIP	RGPD8 RGPD1 RGPD5	8.31e-05	11	152	3	PF01465
Domain	Ran_BP1	RGPD8 RGPD1 RGPD5	1.10e-04	12	152	3	PF00638
Domain	RANBD1	RGPD8 RGPD1 RGPD5	1.10e-04	12	152	3	PS50196
Domain	GRIP_dom	RGPD8 RGPD1 RGPD5	1.10e-04	12	152	3	IPR000237
Domain	GRIP	RGPD8 RGPD1 RGPD5	1.10e-04	12	152	3	PS50913
Domain	-	RRAS2 SAMD9 PEX1 CHST6 CARD10 RAD54L2 ARHGAP35 ABCA9 DNAH1 SULT1E1 DHX15 NWD2 DGUOK SHPRH ASCC3 YME1L1 DNAH11	1.24e-04	746	152	17	3.40.50.300
Domain	TPR-like_helical_dom	SAMD9 RGPD8 ATR RGPD1 CFAP54 SMG7 EDRF1 CFAP46 RGPD5	1.25e-04	233	152	9	IPR011990
Domain	RanBD	RGPD8 RGPD1 RGPD5	1.42e-04	13	152	3	SM00160
Domain	Ran_bind_dom	RGPD8 RGPD1 RGPD5	1.42e-04	13	152	3	IPR000156
Domain	cNMP-bd_CS	HCN4 HCN1 CNBD2	2.74e-04	16	152	3	IPR018488
Domain	Kinesin_motor_CS	KIF4A KIF4B KIF5A KIF22	3.38e-04	41	152	4	IPR019821
Domain	Ion_trans_N	HCN4 HCN1	3.91e-04	4	152	2	IPR013621
Domain	Ion_trans_N	HCN4 HCN1	3.91e-04	4	152	2	PF08412
Domain	REJ	PKD1L1 PKDREJ	3.91e-04	4	152	2	PS51111
Domain	REJ_dom	PKD1L1 PKDREJ	3.91e-04	4	152	2	IPR014010
Domain	Kinesin-like_fam	KIF4A KIF4B KIF5A KIF22	4.07e-04	43	152	4	IPR027640
Domain	-	KIF4A KIF4B KIF5A KIF22	4.44e-04	44	152	4	3.40.850.10
Domain	Kinesin	KIF4A KIF4B KIF5A KIF22	4.44e-04	44	152	4	PF00225
Domain	KISc	KIF4A KIF4B KIF5A KIF22	4.44e-04	44	152	4	SM00129
Domain	KINESIN_MOTOR_1	KIF4A KIF4B KIF5A KIF22	4.44e-04	44	152	4	PS00411
Domain	Kinesin_motor_dom	KIF4A KIF4B KIF5A KIF22	4.44e-04	44	152	4	IPR001752
Domain	KINESIN_MOTOR_2	KIF4A KIF4B KIF5A KIF22	4.44e-04	44	152	4	PS50067
Domain	BAGE	BAGE2 BAGE3	6.47e-04	5	152	2	IPR012530
Domain	BAGE	BAGE2 BAGE3	6.47e-04	5	152	2	PF08180
Domain	PH_dom-like	RGPD8 NET1 OBSCN RGPD1 ARHGEF12 RABGAP1 PLEKHM1 GAB2 PTK2B GTF2H1 RGPD5	7.44e-04	426	152	11	IPR011993
Domain	PKD/REJ-like	PKD1L1 PKDREJ	9.66e-04	6	152	2	IPR002859
Domain	REJ	PKD1L1 PKDREJ	9.66e-04	6	152	2	PF02010
Domain	AAA	PEX1 ABCA9 DHX15 ASCC3 YME1L1 DNAH11	1.17e-03	144	152	6	SM00382
Domain	AAA+_ATPase	PEX1 ABCA9 DHX15 ASCC3 YME1L1 DNAH11	1.17e-03	144	152	6	IPR003593
Domain	GGT_peptidase	GGT1 GGT3P	1.35e-03	7	152	2	IPR000101
Domain	G_glu_transpept	GGT1 GGT3P	1.35e-03	7	152	2	PF01019
Domain	Rab_bind	RGPD8 RGPD1	1.35e-03	7	152	2	PF16704
Domain	G_GLU_TRANSPEPTIDASE	GGT1 GGT3P	1.35e-03	7	152	2	PS00462
Domain	GCC2_Rab_bind	RGPD8 RGPD1	1.35e-03	7	152	2	IPR032023
Domain	Hlx-hairpin-Hlx_DNA-bd_motif	MUS81 KIF22	1.35e-03	7	152	2	IPR003583
Domain	HhH1	MUS81 KIF22	1.35e-03	7	152	2	SM00278
Domain	-	RGPD8 ATR RGPD1 CFAP54 SMG7 EDRF1 CFAP46	1.55e-03	207	152	7	1.25.40.10
Domain	DH_1	NET1 OBSCN ARHGEF38 ARHGEF12	1.73e-03	63	152	4	PS00741
Domain	CNMP_BINDING_1	HCN4 HCN1 CNBD2	2.20e-03	32	152	3	PS00888
Domain	CNMP_BINDING_2	HCN4 HCN1 CNBD2	2.20e-03	32	152	3	PS00889
Domain	Plexin_cytopl	PLXNA3 PLXNA2	2.28e-03	9	152	2	PF08337
Domain	Plexin_cytoplasmic_RasGAP_dom	PLXNA3 PLXNA2	2.28e-03	9	152	2	IPR013548
Domain	Plexin	PLXNA3 PLXNA2	2.28e-03	9	152	2	IPR031148
Domain	RhoGEF	NET1 OBSCN ARHGEF38 ARHGEF12	2.29e-03	68	152	4	SM00325
Domain	-	ATR USP9X RICTOR ANKAR PDS5A BRAT1 HECTD1	2.30e-03	222	152	7	1.25.10.10
Domain	TPR_REGION	RGPD8 RGPD1 SMG7 EDRF1 CFAP46 RGPD5	2.33e-03	165	152	6	PS50293
Domain	TPR	RGPD8 RGPD1 SMG7 EDRF1 CFAP46 RGPD5	2.33e-03	165	152	6	PS50005
Domain	RhoGEF	NET1 OBSCN ARHGEF38 ARHGEF12	2.55e-03	70	152	4	PF00621
Domain	DH_2	NET1 OBSCN ARHGEF38 ARHGEF12	2.55e-03	70	152	4	PS50010
Domain	cNMP	HCN4 HCN1 CNBD2	2.63e-03	34	152	3	SM00100
Domain	cNMP_binding	HCN4 HCN1 CNBD2	2.63e-03	34	152	3	PF00027
Domain	-	NET1 OBSCN ARHGEF38 ARHGEF12	2.68e-03	71	152	4	1.20.900.10
Domain	DH-domain	NET1 OBSCN ARHGEF38 ARHGEF12	2.68e-03	71	152	4	IPR000219
Domain	-	RGPD8 RGPD1	2.84e-03	10	152	2	1.10.220.60
Domain	cNMP-bd_dom	HCN4 HCN1 CNBD2	2.86e-03	35	152	3	IPR000595
Domain	CNMP_BINDING_3	HCN4 HCN1 CNBD2	2.86e-03	35	152	3	PS50042
Domain	GPS	PKD1L1 PKDREJ ADGRG4	3.35e-03	37	152	3	IPR000203
Domain	PKD_channel	PKD1L1 PKDREJ	3.45e-03	11	152	2	PF08016
Domain	PKD1_2_channel	PKD1L1 PKDREJ	3.45e-03	11	152	2	IPR013122
Domain	cNMP-bd-like	HCN4 HCN1 CNBD2	3.62e-03	38	152	3	IPR018490
Domain	GDS_CDC24_CS	NET1 OBSCN ARHGEF12	3.90e-03	39	152	3	IPR001331
Domain	LDLR_class-A_CS	MALRD1 LRP4 C6	4.19e-03	40	152	3	IPR023415
Domain	-	RGPD8 NET1 OBSCN RGPD1 ARHGEF12 RABGAP1 PLEKHM1 GAB2 GTF2H1	4.79e-03	391	152	9	2.30.29.30
Domain	START	STARD13 ACOT11	4.84e-03	13	152	2	SM00234
Domain	Dynein_heavy_chain_D4_dom	DNAH1 DNAH11	5.62e-03	14	152	2	IPR024317
Domain	Dynein_HC_stalk	DNAH1 DNAH11	5.62e-03	14	152	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH1 DNAH11	5.62e-03	14	152	2	IPR013602
Domain	DHC_N2	DNAH1 DNAH11	5.62e-03	14	152	2	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH1 DNAH11	5.62e-03	14	152	2	IPR011704
Domain	K_chnl_volt-dep_EAG/ELK/ERG	HCN4 HCN1	5.62e-03	14	152	2	IPR003938
Domain	MT	DNAH1 DNAH11	5.62e-03	14	152	2	PF12777
Domain	AAA_8	DNAH1 DNAH11	5.62e-03	14	152	2	PF12780
Domain	AAA_5	DNAH1 DNAH11	5.62e-03	14	152	2	PF07728
Domain	Rho_GTPase_activation_prot	STARD13 PLXNA3 ARHGAP35 PLXNA2	5.79e-03	88	152	4	IPR008936
Domain	Ldl_recept_a	MALRD1 LRP4 C6	5.84e-03	45	152	3	PF00057
Domain	DHC_fam	DNAH1 DNAH11	6.44e-03	15	152	2	IPR026983
Domain	START_lipid-bd_dom	STARD13 ACOT11	6.44e-03	15	152	2	IPR002913
Domain	Dynein_heavy	DNAH1 DNAH11	6.44e-03	15	152	2	PF03028
Domain	START	STARD13 ACOT11	6.44e-03	15	152	2	PF01852
Domain	Dynein_heavy_dom	DNAH1 DNAH11	6.44e-03	15	152	2	IPR004273
Domain	START	STARD13 ACOT11	6.44e-03	15	152	2	PS50848
Domain	ARM-type_fold	ATR USP9X RICTOR APOB ANKAR PDS5A BRAT1 HECTD1	6.65e-03	339	152	8	IPR016024
Domain	ARM-like	ATR USP9X RICTOR ANKAR PDS5A BRAT1 HECTD1	6.69e-03	270	152	7	IPR011989
Domain	LDLRA_1	MALRD1 LRP4 C6	6.99e-03	48	152	3	PS01209
Domain	-	HCN4 HCN1 CNBD2	6.99e-03	48	152	3	2.60.120.10
Domain	LDrepeatLR_classA_rpt	MALRD1 LRP4 C6	7.41e-03	49	152	3	IPR002172
Domain	LDLa	MALRD1 LRP4 C6	7.41e-03	49	152	3	SM00192
Domain	LDLRA_2	MALRD1 LRP4 C6	7.41e-03	49	152	3	PS50068
Domain	TPR-contain_dom	RGPD8 RGPD1 SMG7 EDRF1 RGPD5	7.70e-03	150	152	5	IPR013026
Pubmed	Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors.	RRAS2 TMEM79 NUMA1 UNC13D RB1CC1 BIRC6 ESCO2 ZMAT5 PIGH DGUOK PDS5A USPL1 HECTD1	1.00e-08	359	156	13	35559673
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	NOL4 NET1 GPT PEX1 RICTOR MTPAP SLC4A1 INTS10 METTL13 GTF2H1 SMG7 GSE1 LRP4 STK39 ASCC3 YME1L1 VPS53 PML	2.96e-06	1116	156	18	31753913
Pubmed	Complex genomic rearrangements lead to novel primate gene function.	RGPD8 RGPD1 RGPD5	3.06e-06	7	156	3	15710750
Pubmed	Kinesin family in murine central nervous system.	KIF4A KIF4B KIF5A	3.06e-06	7	156	3	1447303
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	LRWD1 ENPP1 NUMA1 PI4K2A CIR1 APOB RB1CC1 BIRC6 MTPAP YARS1 DHX15 METTL13 GLRX PDS5A KDM2A BRAT1 HECTD1 SOAT1 KIF22	6.16e-06	1297	156	19	33545068
Pubmed	Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference.	KIF4A KIF4B KIF22	1.42e-05	11	156	3	15843429
Pubmed	KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway.	KIF4A KIF4B	2.00e-05	2	156	2	36482480
Pubmed	BALB.D2-Mlsa--a new congenic mouse strain.	IDH1 SOAT1	2.00e-05	2	156	2	6230784
Pubmed	ApoB siRNA-induced liver steatosis is resistant to clearance by the loss of fatty acid transport protein 5 (Fatp5).	APOB SLC27A5	2.00e-05	2	156	2	21826528
Pubmed	The multiple functions of kinesin-4 family motor protein KIF4 and its clinical potential.	KIF4A KIF4B	2.00e-05	2	156	2	30081192
Pubmed	Cross-sectional and longitudinal association of serum alanine aminotransaminase and γ-glutamyltransferase with metabolic syndrome in middle-aged and elderly Chinese people.	GPT GGT1	2.00e-05	2	156	2	21199427
Pubmed	Chromokinesin Kif4 promotes proper anaphase in mouse oocyte meiosis.	KIF4A KIF4B	2.00e-05	2	156	2	31067151
Pubmed	Peripheral N- and C-terminal domains determine deactivation kinetics of HCN channels.	HCN4 HCN1	2.00e-05	2	156	2	17548059
Pubmed	Cellular motor protein KIF-4 associates with retroviral Gag.	KIF4A KIF4B	2.00e-05	2	156	2	10559369
Pubmed	KIF4 regulates midzone length during cytokinesis.	KIF4A KIF4B	2.00e-05	2	156	2	21565503
Pubmed	Relationships of elevated levels of serum hepatic enzymes and alcohol intake with arterial stiffness in men.	GPT GGT1	2.00e-05	2	156	2	25437895
Pubmed	A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally.	KIF4A KIF4B	2.00e-05	2	156	2	7929562
Pubmed	Downregulation of FIP200 induces apoptosis of glioblastoma cells and microvascular endothelial cells by enhancing Pyk2 activity.	RB1CC1 PTK2B	2.00e-05	2	156	2	21602932
Pubmed	Impact of GTF2H1 and RAD54L2 polymorphisms on the risk of lung cancer in the Chinese Han population.	RAD54L2 GTF2H1	2.00e-05	2	156	2	36384536
Pubmed	The congenital goiter mutation is linked to the thyroglobulin gene in the mouse.	GPT TG	2.00e-05	2	156	2	2882514
Pubmed	Whole genome expression microarray reveals novel roles for Kif4 in monocyte/macrophage cells.	KIF4A KIF4B	2.00e-05	2	156	2	31486502
Pubmed	Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization.	KIF4A KIF4B	2.00e-05	2	156	2	10773663
Pubmed	Missense Pathogenic variants in KIF4A Affect Dental Morphogenesis Resulting in X-linked Taurodontism, Microdontia and Dens-Invaginatus.	KIF4A KIF4B	2.00e-05	2	156	2	31616463
Pubmed	Risk of non-medullary thyroid cancer influenced by polymorphic variation in the thyroglobulin gene.	TSHR TG	2.00e-05	2	156	2	14633662
Pubmed	Kif4 regulates the expression of VEGFR1 through the PI3K/Akt signaling pathway in RAW264.7 monocytes/macrophages.	KIF4A KIF4B	2.00e-05	2	156	2	28350061
Pubmed	Colocalization of hyperpolarization-activated, cyclic nucleotide-gated channel subunits in rat retinal ganglion cells.	HCN4 HCN1	2.00e-05	2	156	2	21456027
Pubmed	Alanine aminotransferase and gamma-glutamyl transferase are associated with the metabolic syndrome but not with angiographically determined coronary atherosclerosis.	GPT GGT1	2.00e-05	2	156	2	18708042
Pubmed	Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli.	HCN4 HCN1	2.00e-05	2	156	2	11675786
Pubmed	Human fibrocytes coexpress thyroglobulin and thyrotropin receptor.	TSHR TG	2.00e-05	2	156	2	22517745
Pubmed	Kif4 interacts with EB1 and stabilizes microtubules downstream of Rho-mDia in migrating fibroblasts.	KIF4A KIF4B	2.00e-05	2	156	2	24658398
Pubmed	Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella.	DNAH1 DNAH11	2.00e-05	2	156	2	24360805
Pubmed	Tracing haematopoietic stem cell formation at single-cell resolution.	RICTOR COMMD10	2.00e-05	2	156	2	27225119
Pubmed	Association between Liver Enzymes with Metabolically Unhealthy Obese Phenotype.	GPT GGT1	2.00e-05	2	156	2	30134916
Pubmed	Molecular composition and functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells.	HCN4 HCN1	2.00e-05	2	156	2	19135060
Pubmed	Structural basis for the ATP-induced isomerization of kinesin.	KIF4A KIF4B	2.00e-05	2	156	2	23500491
Pubmed	Association of gamma-glutamyl transferase and alanine aminotransferase with type 2 diabetes mellitus incidence in middle-aged Japanese men: 12-year follow up.	GPT GGT1	2.00e-05	2	156	2	30204299
Pubmed	Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein.	KIF4A KIF4B	2.00e-05	2	156	2	9658142
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	PEX1 RICTOR MTPAP VPS13D METTL13 C17orf75 SMG7 BBS7 PDS5A BRAT1 GMPPB VPS53	2.03e-05	606	156	12	36538041
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH1 DNAH17 DNAH11	3.11e-05	14	156	3	9373155
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	STARD13 RRAS2 LRWD1 ACP1 NUMA1 KIF4A RICTOR BIRC6 MTPAP DHX15 METTL13 GTF2H1 VPS33B PDS5A KDM2A ASCC3 GMPPB YME1L1	3.92e-05	1353	156	18	29467282
Pubmed	Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J intercross and a combined intercross involving NZB/B1NJ, RF/J, MRL/MpJ, and SJL/J mouse strains.	PI4K2A APOB PIGH	5.75e-05	17	156	3	17496333
Pubmed	Positive correlations of liver enzymes with metabolic syndrome including insulin resistance in newly diagnosed type 2 diabetes mellitus.	GPT GGT1	5.98e-05	3	156	2	20972737
Pubmed	TSH stimulation of human thyroglobulin and thyroid peroxidase gene transcription is partially dependent on internalization.	TSHR TG	5.98e-05	3	156	2	34896620
Pubmed	Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart.	HCN4 HCN1	5.98e-05	3	156	2	22652004
Pubmed	Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating.	HCN4 HCN1	5.98e-05	3	156	2	21187420
Pubmed	Independent and supra-additive effects of alcohol consumption, cigarette smoking, and metabolic syndrome on the elevation of serum liver enzyme levels.	GPT GGT1	5.98e-05	3	156	2	23667618
Pubmed	Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart.	HCN4 HCN1	5.98e-05	3	156	2	21945247
Pubmed	Tumor formation via loss of a molecular motor protein.	KIF4A KIF4B	5.98e-05	3	156	2	16890532
Pubmed	Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.	HCN4 HCN1	5.98e-05	3	156	2	22006928
Pubmed	KIF4 mediates anterograde translocation and positioning of ribosomal constituents to axons.	KIF4A KIF4B	5.98e-05	3	156	2	19158085
Pubmed	Iodinated TG in Thyroid Follicles Regulate TSH/TSHR Signaling for NIS Expression.	TSHR TG	5.98e-05	3	156	2	28396984
Pubmed	IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics.	IDH1 COMMD10	5.98e-05	3	156	2	22763442
Pubmed	Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein.	KIF4A KIF4B	5.98e-05	3	156	2	10978527
Pubmed	Liver enzymes: interaction analysis of smoking with alcohol consumption or BMI, comparing AST and ALT to γ-GT.	GPT GGT1	5.98e-05	3	156	2	22132177
Pubmed	Homology between TSH-R/Tg/TPO and Hashimoto's encephalopathy autoantigens.	TSHR TG	5.98e-05	3	156	2	31585887
Pubmed	Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice.	IDH1 COMMD10	5.98e-05	3	156	2	26787889
Pubmed	Identification of plexin family molecules in mice.	PLXNA3 PLXNA2	5.98e-05	3	156	2	8806646
Pubmed	HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age-dependent changes.	HCN4 HCN1	5.98e-05	3	156	2	33181864
Pubmed	Assignment of the gene locus for the sixth component (C6) of complement in mice to chromosome 15.	GPT C6	5.98e-05	3	156	2	4077152
Pubmed	Glucose intolerance and serum aminotransferase activities in Japanese men.	GPT GGT1	5.98e-05	3	156	2	12480555
Pubmed	The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development.	IDH1 COMMD10	5.98e-05	3	156	2	27956631
Pubmed	Elevated liver enzymes in women with a family history of diabetes.	GPT GGT1	5.98e-05	3	156	2	18242760
Pubmed	Kinesin-1 Is a New Actor Involved in Platelet Secretion and Thrombus Stability.	UNC13D COMMD10	5.98e-05	3	156	2	29519941
Pubmed	Suppression of Pyk2 kinase and cellular activities by FIP200.	RB1CC1 PTK2B	5.98e-05	3	156	2	10769033
Pubmed	Critical role of SMG7 in activation of the ATR-CHK1 axis in response to genotoxic stress.	ATR SMG7	5.98e-05	3	156	2	33820915
Pubmed	Differential expression of plexin-A subfamily members in the mouse nervous system.	PLXNA3 PLXNA2	5.98e-05	3	156	2	11241833
Pubmed	Relation of coffee consumption and serum liver enzymes in Japanese men and women with reference to effect modification of alcohol use and body mass index.	GPT GGT1	5.98e-05	3	156	2	20205615
Pubmed	EP3 activation facilitates bladder excitability via HCN channels on ICCs.	HCN4 HCN1	5.98e-05	3	156	2	28131828
Pubmed	The human MyoD1 (MYF3) gene maps on the short arm of chromosome 11 but is not associated with the WAGR locus or the region for the Beckwith-Wiedemann syndrome.	IDH1 SOAT1	5.98e-05	3	156	2	2176177
Pubmed	KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity.	KIF4A KIF4B	5.98e-05	3	156	2	16630823
Pubmed	Requirement for Rictor in homeostasis and function of mature B lymphoid cells.	RICTOR COMMD10	5.98e-05	3	156	2	23958952
Pubmed	Relationship of clinical features and laboratory parameters to thyroid echogenicity measured by standardized grey scale ultrasonography in patients with Hashimoto's thyroiditis.	TSHR TG	5.98e-05	3	156	2	12709678
Pubmed	Association between serum liver enzymes and all-cause mortality: The Japan Public Health Center-based Prospective Study.	GPT GGT1	5.98e-05	3	156	2	30566759
Pubmed	Different gamma-glutamyl transpeptidase mRNAs are expressed in human liver and kidney.	GGT1 GGT3P	5.98e-05	3	156	2	2573352
Pubmed	CircKIF4A enhances osteosarcoma proliferation and metastasis by sponging MiR-515-5p and upregulating SLC7A11.	KIF4A KIF4B	5.98e-05	3	156	2	35579738
Pubmed	Comprehensive Screening of Eight Known Causative Genes in Congenital Hypothyroidism With Gland-in-Situ.	TSHR TG	5.98e-05	3	156	2	27525530
Pubmed	Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment.	NUMA1 KIF4A	5.98e-05	3	156	2	35926461
Pubmed	Biological variation of thyroid autoantibodies and thyroglobulin.	TSHR TG	5.98e-05	3	156	2	17902201
Pubmed	Glutaredoxin modulates platelet-derived growth factor-dependent cell signaling by regulating the redox status of low molecular weight protein-tyrosine phosphatase.	ACP1 GLRX	5.98e-05	3	156	2	16893901
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	GNPTAB RICTOR ARHGAP35 BIRC6 VPS13D METTL13 DNAH17 PDS5A KDM2A HECTD1	8.30e-05	493	156	10	15368895
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	RRAS2 LRWD1 ACP1 NUMA1 BIRC6 MTPAP METTL13 VPS33B PDS5A ASCC3 GMPPB YME1L1	8.56e-05	704	156	12	29955894
Pubmed	Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.	RGPD1 MCAM ARHGEF12 RICTOR MTPAP STK39	8.88e-05	160	156	6	31678930
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	TAPT1 PI4K2A MCAM PEX1 RABGAP1 PLEKHM1 VPS13D VPS33B YME1L1 SOAT1	9.94e-05	504	156	10	34432599
Pubmed	Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry.	NUMA1 PEX1 GLRX GREB1	1.11e-04	55	156	4	18570454
Pubmed	Functional expression of the human HCN3 channel.	HCN4 HCN1	1.19e-04	4	156	2	16043489
Pubmed	ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis.	ATR PML	1.19e-04	4	156	2	16891316
Pubmed	Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.	HCN4 HCN1	1.19e-04	4	156	2	9405696
Pubmed	Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.	HCN4 HCN1	1.19e-04	4	156	2	12928435
Pubmed	Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells.	IDH1 COMMD10	1.19e-04	4	156	2	36652477
Pubmed	Chromosome assignment of four plexin A genes (Plxna1, Plxna2, Plxna3, Plxna4) in mouse, rat, Syrian hamster and Chinese hamster.	PLXNA3 PLXNA2	1.19e-04	4	156	2	11306810
Pubmed	Hyperpolarization-activated and cyclic nucleotide-gated channels are differentially expressed in juxtaglomerular cells in the olfactory bulb of mice.	HCN4 HCN1	1.19e-04	4	156	2	20140458
Pubmed	PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.	PLXNA3 PLXNA2	1.19e-04	4	156	2	25518740
Pubmed	Kinesin KIF4 regulates intracellular trafficking and stability of the human immunodeficiency virus type 1 Gag polyprotein.	KIF4A KIF4B	1.19e-04	4	156	2	18684836
Pubmed	Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder.	HCN4 HCN1	1.19e-04	4	156	2	22748890
Pubmed	Semaphorin-plexin signalling genes associated with human breast tumourigenesis.	PLXNA3 PLXNA2	1.19e-04	4	156	2	21925246
Pubmed	Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia.	DNAH1 DNAH11	1.19e-04	4	156	2	18492703
Pubmed	Kif4 Is Essential for Mouse Oocyte Meiosis.	KIF4A KIF4B	1.19e-04	4	156	2	28125646
Pubmed	Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.	HCN4 HCN1	1.19e-04	4	156	2	9630217
Pubmed	Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells.	APOB SOAT1	1.19e-04	4	156	2	15308631
Pubmed	Determination of cell adhesion sites of neuropilin-1.	PLXNA3 PLXNA2	1.19e-04	4	156	2	10725340
Interaction	RGPD3 interactions	RGPD8 NUMA1 RGPD1 RICTOR PML RGPD5	1.39e-06	47	152	6	int:RGPD3
Interaction	THBS3 interactions	LRWD1 PEX1 MTPAP METTL13 BBS7 ASCC3	2.02e-05	74	152	6	int:THBS3
Interaction	RGPD4 interactions	RGPD8 RGPD1 RICTOR RGPD5	2.05e-05	22	152	4	int:RGPD4
GeneFamily	Dyneins, axonemal	DNAH1 DNAH17 DNAH11	1.09e-04	17	101	3	536
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF4A KIF4B KIF5A KIF22	1.25e-04	46	101	4	622
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	NET1 OBSCN ARHGEF38 ARHGEF12	5.07e-04	66	101	4	722
GeneFamily	Plexins	PLXNA3 PLXNA2	1.08e-03	9	101	2	683
GeneFamily	Cyclic nucleotide gated channels	HCN4 HCN1	1.35e-03	10	101	2	250
GeneFamily	CD molecules\|Gamma-glutamyltransferases	GGT1 GGT3P	2.32e-03	13	101	2	564
GeneFamily	StAR related lipid transfer domain containing	STARD13 ACOT11	3.09e-03	15	101	2	759
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	RGPD8 RGPD1 CFAP46 RGPD5	3.95e-03	115	101	4	769
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	STARD13 RRAS2 TRIM2 ATR USP9X CERS6 RABGAP1 DHX15 TLE4 MARF1 PDS5A STK39 ASCC3	4.04e-06	466	154	13	M13522
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	TAPT1 NET1 FAM13C NUMA1 RICTOR RABGAP1 VPS13D MARF1	2.06e-07	177	155	8	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	PMS2 NUMA1 OBSCN KMT2E SMG7 ACOT11 KDM2A	1.93e-06	166	155	7	32d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HCN4 DNAH1 AGBL4 CFAP54 C6 CFAP46 DNAH11	2.17e-06	169	155	7	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	LA-03._Atrial_Cardiomyocyte\|LA / Chamber and Cluster_Paper	OBSCN CERS6 LRRTM3 DYSF AGBL4 PRELID2 ACOT11	4.87e-06	191	155	7	5d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell	TCGA-Thryoid-Solid_Tissue_Normal-Thryoid_normal_tissue-Thryoid_normal_tissue-3\|TCGA-Thryoid / Sample_Type by Project: Shred V9	NOL4 TAPT1 VIT ABCA9 TLE4 C6	1.67e-05	154	155	6	4e9203c220a44c70cd7979796a0b461991422257
ToppCell	TCGA-Thryoid-Solid_Tissue_Normal-Thryoid_normal_tissue-Thryoid_normal_tissue\|TCGA-Thryoid / Sample_Type by Project: Shred V9	NOL4 TAPT1 VIT ABCA9 TLE4 C6	1.93e-05	158	155	6	8e48952af0831a1fc71ad422e8216b5a92a75991
ToppCell	TCGA-Thryoid-Solid_Tissue_Normal-Thryoid_normal_tissue\|TCGA-Thryoid / Sample_Type by Project: Shred V9	NOL4 TAPT1 VIT ABCA9 TLE4 C6	1.93e-05	158	155	6	e5b55c15a8c99c8d7fc94949f0d3c22e0c3fee7b
ToppCell	TCGA-Thryoid-Solid_Tissue_Normal\|TCGA-Thryoid / Sample_Type by Project: Shred V9	NOL4 TAPT1 VIT ABCA9 TLE4 C6	1.93e-05	158	155	6	55214d674808584e4d48f8c5e3b8c0e206cb9bb8
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf-Oligodendrocyte.Tfr.Tmem2_(Tmem2)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	PTCHD3 PKD1L1 UNC13D PKDREJ BTBD16	3.03e-05	103	155	5	287e945ef2f9646f1ff4a4c50fe6e8a5e7fe0d92
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOL4 OBSCN APOB DNAH1 KIF5A DNAH11	4.55e-05	184	155	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOL4 OBSCN APOB DNAH1 KIF5A DNAH11	4.55e-05	184	155	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOL4 OBSCN APOB DNAH1 KIF5A DNAH11	4.55e-05	184	155	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Adult-Epithelial-ciliated_cell-D175\|Adult / Lineage, Cell type, age group and donor	UROC1 AGBL4 CFAP54 C6 CFAP46 DNAH11	4.69e-05	185	155	6	30f4980dee6cd5959655f8d74049f3bfb5312611
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	GNPTAB ARHGEF12 RABGAP1 BIRC6 VPS13D MARF1	4.83e-05	186	155	6	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	TMEM79 PI4K2A ARHGEF12 VPS13D MARF1 KDM2A	5.12e-05	188	155	6	2c4e791df69a9df29922f9117e5cac7787c129ce
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	UAP1 VIT ABCA9 ADGRG4 KIAA1755 GREB1	5.28e-05	189	155	6	d531399749409d614adca13d181830c6e3287508
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	CIR1 RICTOR RB1CC1 KDM2A USPL1 RGPD5	5.59e-05	191	155	6	1ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell\|Adult / Lineage, Cell type, age group and donor	UAP1 VIT ABCA9 ADGRG4 KIAA1755 GREB1	5.76e-05	192	155	6	d21f0f577156f17c899b08871046a26b88aea011
ToppCell	IPF-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	TRIM2 AGBL4 CFAP54 C6 CFAP46 DNAH11	5.76e-05	192	155	6	d903bbd6c18e29e2c4cdedeb3fea1fd5ad7baa11
ToppCell	COPD-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	TRIM2 AGBL4 CFAP54 C6 CFAP46 DNAH11	5.76e-05	192	155	6	eab1105cd1a98cfcd3d74dc5c9b89e1799bba59e
ToppCell	IPF-Epithelial-Ciliated\|IPF / Disease state, Lineage and Cell class	TRIM2 AGBL4 CFAP54 C6 CFAP46 DNAH11	5.76e-05	192	155	6	354adc1354bf596fbc60dd45c0169688e6f45165
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	ATR USP9X ZBTB41 BIRC6 PDS5A HECTD1	5.93e-05	193	155	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	TRIM2 ARHGEF12 AGBL4 CFAP54 CFAP46 DNAH11	6.27e-05	195	155	6	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	UAP1 VIT ABCA9 ADGRG4 KIAA1755 GREB1	6.27e-05	195	155	6	f54bc4454270ff06e85596f98199372b50d0179f
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	TRIM2 ARHGEF12 AGBL4 CFAP54 CFAP46 DNAH11	6.27e-05	195	155	6	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	TRIM2 ARHGEF12 AGBL4 CFAP54 CFAP46 DNAH11	6.45e-05	196	155	6	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	TRIM2 ARHGEF12 AGBL4 CFAP54 CFAP46 DNAH11	6.45e-05	196	155	6	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FCRL2 ERN1 RGPD1 TSHR PTK2B CFAP54	6.64e-05	197	155	6	749e0e332644543cbdf2ee38c2b301ce0a019a7f
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	SAMD9 BACH1 CIR1 RICTOR KMT2E KDM2A	6.64e-05	197	155	6	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	facs-Tongue-nan-3m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NET1 USP9X ARHGEF12 RB1CC1 DHX15 SMG7	6.83e-05	198	155	6	2f03f8897dd7cce6d8296638e14e11ec16bcf624
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	SAMD9 BACH1 CIR1 RICTOR KMT2E KDM2A	6.83e-05	198	155	6	44417089b62056269cac38d3134ff209c05b7007
ToppCell	facs-Tongue-nan-3m\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NET1 USP9X ARHGEF12 RB1CC1 DHX15 SMG7	6.83e-05	198	155	6	f2a4057f038ef7225a5b98a7ab068c30dff4eadd
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SAMD9 BACH1 CIR1 RICTOR KMT2E KDM2A	6.83e-05	198	155	6	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	facs-Tongue-nan-3m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NET1 USP9X ARHGEF12 RB1CC1 DHX15 SMG7	7.02e-05	199	155	6	8d50e1ee58710d896c0204937331d9f4dcd38de0
Drug	Pirenzepine dihydrochloride [29868-97-1]; Down 200; 9.4uM; HL60; HG-U133A	NUMA1 MCAM DYSF MTERF4 VPS13D GSE1 VPS33B DGUOK PDS5A STK39	1.10e-06	197	156	10	1388_DN
Disease	cortical thickness	ARHGEF12 MUS81 POLR2M RABGAP1 SLC25A26 VIT ARHGAP35 DYSF PLEKHM1 TG AGBL4 VPS13D MALRD1 SMG7 LRP4 KIAA1755 PLXNA2 SOAT1	1.99e-05	1113	153	18	EFO_0004840
Disease	sick sinus syndrome (implicated_via_orthology)	HCN4 HCN1	7.99e-05	3	153	2	DOID:13884 (implicated_via_orthology)
Disease	Autoimmune thyroiditis	TSHR TG	1.59e-04	4	153	2	C0920350
Disease	Ataxia	HCN1 UROC1 YME1L1	2.89e-04	25	153	3	C0004134
Disease	Neoplasm of uncertain or unknown behavior of ovary	RRAS2 PMS2 ATR	4.52e-04	29	153	3	C0496920
Disease	Ovarian Carcinoma	RRAS2 PMS2 ATR	5.01e-04	30	153	3	C0029925
Disease	aflatoxins-related hepatocellular carcinoma (biomarker_via_orthology)	GGT1 GGT3P	5.51e-04	7	153	2	DOID:5022 (biomarker_via_orthology)
Disease	acute promyelocytic leukemia (is_implicated_in)	NUMA1 PML	5.51e-04	7	153	2	DOID:0060318 (is_implicated_in)
Disease	Intellectual Disability	ZNF142 NUDT2 KIF4A UROC1 KMT2E BBS7 KIF5A ASCC3 VPS53	5.66e-04	447	153	9	C3714756
Disease	Urologic Neoplasms	ATR OGG1	7.33e-04	8	153	2	C0042076
Disease	alcohol dependence (biomarker_via_orthology)	GGT1 GGT3P	7.33e-04	8	153	2	DOID:0050741 (biomarker_via_orthology)
Disease	Cancer of Urinary Tract	ATR OGG1	7.33e-04	8	153	2	C0751571
Disease	Graves' disease (is_implicated_in)	TSHR OGG1 TG	1.09e-03	39	153	3	DOID:12361 (is_implicated_in)
Disease	Prostatic Neoplasms	SAMD9 ATR UNC13D IDH1 OGG1 GGT1 SULT1E1 PDS5A GREB1 PML	1.46e-03	616	153	10	C0033578
Disease	Malignant neoplasm of prostate	SAMD9 ATR UNC13D IDH1 OGG1 GGT1 SULT1E1 PDS5A GREB1 PML	1.46e-03	616	153	10	C0376358
Disease	calcium measurement	NUMA1 FCHO2 ABCA9 GGT1 GAB2 SLC4A1 AGBL4 TLE4 KIF5A ASCC3	1.68e-03	628	153	10	EFO_0004838
Disease	Congenital muscular dystrophy	RYR1 GMPPB	1.70e-03	12	153	2	cv:C0699743
Disease	obsolete_red blood cell distribution width	ASNSD1 SAMD9 ATR BACH1 RGPD1 UNC13D APOB CERS6 SLC25A26 FCHO2 BIRC6 SLC4A1 INTS10 VPS33B PDS5A STK39	1.75e-03	1347	153	16	EFO_0005192
Disease	Acute Promyelocytic Leukemia	NUMA1 IDH1 PML	1.76e-03	46	153	3	C0023487
Disease	binge eating, bipolar disorder	APOB SLC25A26	2.01e-03	13	153	2	EFO_0005924, MONDO_0004985
Disease	Congenital Hypothyroidism	TSHR TG	2.01e-03	13	153	2	C0010308
Disease	gallbladder cancer (is_implicated_in)	RICTOR APOB	2.01e-03	13	153	2	DOID:3121 (is_implicated_in)
Disease	congenital hypothyroidism (implicated_via_orthology)	TSHR TG	2.33e-03	14	153	2	DOID:0050328 (implicated_via_orthology)
Disease	gamma-glutamylphenylalanine measurement	LRRTM3 GGT1	2.68e-03	15	153	2	EFO_0021142
Disease	aspartate aminotransferase measurement	BACH1 OBSCN POLR2M RABGAP1 FCHO2 ARHGAP35 BIRC6 PLEKHM1 GAB2 DHX15 AGBL4 TLE4	2.73e-03	904	153	12	EFO_0004736
Disease	Tremor, Rubral	HCN1 UROC1	3.06e-03	16	153	2	C0750940
Disease	Ataxia, Appendicular	HCN1 UROC1	3.06e-03	16	153	2	C0750937
Disease	Ataxia, Motor	HCN1 UROC1	3.06e-03	16	153	2	C0278161
Disease	Ataxia, Sensory	HCN1 UROC1	3.06e-03	16	153	2	C0240991
Disease	Abnormal coordination	HCN1 UROC1	3.06e-03	16	153	2	C0520966
Disease	Ataxia, Truncal	HCN1 UROC1	3.06e-03	16	153	2	C0427190
Disease	ovarian cancer (is_implicated_in)	PMS2 APOB OGG1	3.10e-03	56	153	3	DOID:2394 (is_implicated_in)
Disease	fatty liver disease (is_marker_for)	GPT GGT1	3.45e-03	17	153	2	DOID:9452 (is_marker_for)
Disease	plasma beta-amyloid 1-40 measurement	STARD13 PDS5A	3.45e-03	17	153	2	EFO_0005659
Disease	cholesterol:total lipids ratio, intermediate density lipoprotein measurement	APOB GAB2 INTS10 LRP4	3.69e-03	121	153	4	EFO_0008595, EFO_0020943
Disease	serum hepcidin measurement	PRELID2 KIAA1755	3.87e-03	18	153	2	EFO_0004504
Disease	Malignant neoplasm of endometrium	PMS2 ATR	3.87e-03	18	153	2	C0007103
Disease	Carcinoma in situ of endometrium	PMS2 ATR	3.87e-03	18	153	2	C0346191
Disease	non-high density lipoprotein cholesterol measurement	PLXNA3 TRIM2 APOB ABCA9 INTS10 AGBL4 ZMAT5 PDS5A ASCC3 DNAH11	4.16e-03	713	153	10	EFO_0005689
Disease	cortical surface area measurement	RRAS2 TRIM2 SAMD9 RGPD1 ARHGEF12 SLC25A26 FCHO2 DYSF PLEKHM1 TG TLE4 KIAA1755 PLXNA2 SOAT1 DNAH11	4.37e-03	1345	153	15	EFO_0010736
Disease	Adenocarcinoma of lung (disorder)	ATR ERN1 ARHGAP35 OGG1 STK39	4.49e-03	206	153	5	C0152013
Disease	free cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	POLR2M APOB BIRC6 INTS10 OR4A15 DNAH11	5.12e-03	303	153	6	EFO_0004612, EFO_0020945
Disease	Global developmental delay	ZNF142 NUDT2 KMT2E VPS53	5.16e-03	133	153	4	C0557874

Protein segments in the cluster

Peptide	Gene	Start	Entry
RRPCQLKDLNENDFL	nan	101	A8MT66
QRPITFLRQVLALCV	GPT	76	P24298
ECEVKLPFNAQRIIS	BACH1	521	O14867
QFLRELFPVLQKRLC	BRAT1	496	Q6PJG6
KINDVICLPVERLSR	BBS7	146	Q8IWZ6
KLTPYLRQCRVIDEQ	CARD10	46	Q9BWT7
FPSQQIARLIECERV	CFAP54	1116	Q96N23
LVQCLRLPKFAEEEN	BIRC6	716	Q9NR09
RVLLPLIFRNVELQC	SLC4A1	871	P02730
LRNPDRLCISQIQKF	BTBD16	51	Q32M84
NKIIPTVDRTLRCFV	ADGRG4	216	Q8IZF6
NTKRLNCFPVLLDVI	ABCA9	976	Q8IUA7
NDLELCVREVVQPLR	ARHGEF38	111	Q9NXL2
RQAAVPLVKVERVFC	GSE1	616	Q14687
PAVLCFRVKNISRLE	FCHO2	591	Q0JRZ9
LQRQVCPDLLRKFAE	CFAP46	641	Q8IYW2
PQVCLKRLYQRAREE	DGUOK	196	Q16854
LCVNFDPKLVAVLRE	DNAH11	716	Q96DT5
QDFVILASRRKPCDN	ACOT11	486	Q8WXI4
QQEFRREFEKALCRP	RAD54L2	441	Q9Y4B4
FRRCLIPKVDNNAIE	NUDT2	11	P50583
FPQCEAKRQLDRIIA	DHX15	771	O43143
LNIPRNAEVAIVCKV	ATP4B	251	P51164
ELRAFVAALKPCQVV	DCLRE1B	281	Q9H816
DQLSNCRLVDLKIPR	CCDC83	251	Q8IWF9
ESNPLCRRLQLKDII	ARHGEF12	916	Q9NZN5
EVICRRVQLPNNFLK	NWD2	1511	Q9ULI1
ADICVREIARKLANP	PDS5A	586	Q29RF7
QKFEECQRLLLDIPL	RGPD5	1161	Q99666
QKFEECQRLLLDIPL	RGPD8	1161	O14715
RKLFVCDVLPLIINN	INTS10	171	Q9NVR2
QPQKRRVCEVEFVFS	LRWD1	476	Q9UFC0
KQDPRVQDFLQRCLE	NET1	281	Q7Z628
ILLKECRNKPNQFIR	ANKAR	1291	Q7Z5J8
RPFIAECRQTIAKLD	RB1CC1	341	Q8TDY2
LETKVRVCSPNERLF	RABGAP1	426	Q9Y3P9
KRTVIEQQPVLCEVF	GGT3P	181	A6NGU5
VICPKVLANFVVDRN	OR8K5	76	Q8NH50
EKLRDVIAQCILPQA	MAPKAPK5	391	Q8IW41
QLDDIRKNPRKFVCL	GNPTAB	1136	Q3T906
DRLLNCREVKEAPNI	GREB1	796	Q4ZG55
LRIPAIQEKSFQCIE	IL31RA	316	Q8NI17
FQLLKDAPCELLRVQ	EDRF1	1066	Q3B7T1
FLIPAKRLCEQVREA	KIAA1755	51	Q5JYT7
LFLQSLRQKQPERLC	GMPPB	231	Q9Y5P6
VEKFRQRILAPCKLE	COMMD10	121	Q9Y6G5
DRCRFLRKVPNIIDL	KCNV1	266	Q6PIU1
CAFPIRAINLQIKER	PLXNA2	356	O75051
QFVRRDAKAIVCISP	PLXNA3	976	P51805
NNLKFITDPFVCRLR	OR4A15	6	Q8NGL6
LVKVDQRERLAPFRQ	KIF22	251	Q14807
ERCQPRNLDKERAVL	KMT2E	161	Q8IZD2
RPRVLQKENTICLLS	ENPP1	661	P22413
KFQGVRLLRQDPIEC	OGG1	126	O15527
GVQKILNARCPLVRF	MTPAP	301	Q9NVV4
DVVCPIQRVVLLFQE	C17orf75	201	Q9HAS0
RLPCRRFIQELFQDV	RICTOR	1666	Q6R327
PLREEIINFNCRKLV	HCN4	576	Q9Y3Q4
LERDPQKRFTCQQAL	PNCK	251	Q6P2M8
PVQVEEVAAKFCRLL	OBSCN	1801	Q5VST9
QAELAIERCIFPERI	PI4K2A	116	Q9BTU6
VAVLCFLANRKVPIR	MALRD1	2091	Q5VYJ5
SNAVKRNVPRCIIIL	BAGE3	51	Q86Y29
CLRAIRDVNVPKFLQ	DNAH1	1781	Q9P2D7
LQVPSCKLDFREIQI	APOB	3756	P04114
QKPRQILCQFIDRIL	ATR	31	Q13535
FLAKCIQDNRLVDLP	HECTD1	2251	Q9ULT8
PLREEIVNFNCRKLV	HCN1	456	O60741
TVFREAIICKNIPRL	IDH1	106	O75874
AVQAKVLRPLRSCDE	KDM2A	696	Q9Y2K7
VDLVRNIPCAVTKRN	C6	491	P13671
PARIIVILQEFCNQI	DNAH17	331	Q9UFH2
FDNRDVAVKRILPEC	ERN1	591	O75460
CRRAQEILSQLPIKQ	GLRX	26	P35754
EERFQRQAIFPKLLC	AGBL4	346	Q5VU57
ERFVAKPCAIALNIQ	CERS6	56	Q6ZMG9
CLIAEPIKQAFRVLS	ESCO2	491	Q56NI9
NRIIVSFTPKNRELC	MARF1	576	Q9Y4F3
KRVLCLPRDENLTAN	ASNSD1	296	Q9NWL6
LLCPSREKAQINIRE	KIF4A	151	O95239
LLCPSREKAQINIRE	KIF4B	151	Q2VIQ3
KVLCRFRPLNQAEIL	KIF5A	11	Q12840
QLVRDNADLRCELPK	KIF5A	846	Q12840
RLQREFCLPASQLKQ	CCDC168	1421	Q8NDH2
TNLEREKRICLPKFQ	CCDC168	6161	Q8NDH2
LKCETRLSPQRLDVQ	FCRL2	126	Q96LA5
EFKQIRSIRCLPLEE	PTK2B	301	Q14289
QIFELCAQEQRKPVR	METTL13	221	Q8N6R0
QERLLRNEKFICKLP	POLR2M	31	P0CAP2
SNAVKRNVPRCIIIL	BAGE2	51	Q86Y30
VFKVICILPNDDKRR	PIWIL3	576	Q7Z3Z3
VACLIRVPSEVVKQR	SLC25A26	101	Q70HW3
KPENVLLFDRECRRV	SBK1	176	Q52WX2
NVVVRLLIRKPECFG	RYR1	2351	P21817
IRNLRKNPNFDICTL	DYSF	1371	O75923
AVRDIFIRAQAAKPC	PEX1	921	O43933
VNATEKNRIEVPFCR	PKD1L1	936	Q8TDX9
KNRIEVPFCRVVGLL	PKD1L1	941	Q8TDX9
AFLVRDIKVRENSCP	COL6A6	1781	A6NMZ7
LFQLRRIAEDCQIPL	PTCHD3	766	Q3KNS1
LPERCVQIAKRELLF	AGPAT2	111	O15120
QILKQPVSERLDFVC	NUMA1	51	Q14980
QKFEECQRLLLDIPL	RGPD1	1146	P0DJD0
VTPQDERIFLCQGKR	MCAM	106	P43121
KPLRIINLNFCEQVD	GAB2	56	Q9UQC2
PICRQALKFLTQIRA	PLEKHM1	881	Q9Y4G2
VIPALKQIREICSLF	USP9X	566	Q93008
DLVEPLCRRLNTLNK	STARD13	101	Q9Y3M8
FERLCAPLFRNIKQE	SOAT1	341	P35610
NIKQEPFSARVLVLC	SOAT1	351	P35610
PKEELQDRLVVVLCN	YARS1	411	P54577
TIPVRIFQDCRNLEL	LRRTM3	171	Q86VH5
QVQQAKKCIREPRFV	SAMD9	276	Q5K651
EPECRRNLVQCLLEK	MTERF4	66	Q7Z6M4
CLPAEKFVQNSIRRE	PKDREJ	1806	Q9NTG1
FLRQALCRLRQEEPQ	PML	351	P29590
PRLIQCENEVGKLLF	SMG7	471	Q92540
NICRSPIAEAVFRKL	ACP1	16	P24666
LVRVIRKFQEQECPP	RRAS2	171	P62070
LDQIDRKPRVQCLKC	SHPRH	666	Q149N8
LCRDIPQLKLVNEVF	TEKT5	406	Q96M29
AFKCQETVRLQPRID	FAM13C	136	Q8NE31
RAFLCEVQDIIPIQL	ARHGAP35	871	Q9NRY4
KIQAIIDSCRRQFPE	NOL4	436	O94818
VVFPVDCIKSRIQVL	SLC25A2	226	Q9BXI2
CFDPKELRIQREQAL	ASCC3	366	Q8N3C0
IFRKDLLQLLVEPCQ	CNBD2	496	Q96M20
ALPFAKIRRVQELCA	CHST6	336	Q9GZX3
DQPFGIQVRNVRCIK	CIR1	116	Q86X95
LNVKIPRLVDVICAS	TLR8	791	Q9NR97
QVTKLCPFQEKIRRQ	GTF2H1	501	P32780
VRDEIFISLQPQLRC	USPL1	311	Q5W0Q7
RKVPELFVCTQQDIL	MINDY4	246	Q4G0A6
EDVIFNRIPFLECRK	SULT1E1	71	P49888
EEILPKLQAENIRCF	SLC27A5	236	Q9Y2P5
EIVKRLNAICAQVIP	TLE4	86	Q04727
INQAIACRRIKAPVV	UROC1	526	Q96N76
RQKQPSFCDLLIIVE	ZBTB41	81	Q5SVQ8
ARAFVPIDLQCIERQ	TMEM79	126	Q9BSE2
LQPLVKRVCDTDRLA	VIT	471	Q6UXI7
VFQSAKPRLDCLIEV	PIGH	156	Q14442
IYRKRIAICQNVVPE	PRELID2	51	Q8N945
IAICQNVVPEILRKS	PRELID2	56	Q8N945
ACLVANILDPRIKQE	VPS53	241	Q5VIR6
CVDNILVKVADPRFI	UAP1	251	Q16222
CVDINVTPDKRQILL	PMS2	331	P54278
RNLFREAKANAPCVI	YME1L1	421	Q96TA2
AILLDEQNKRPCRKF	ZMAT5	46	Q9UDW3
DRRLLQPAQVCDILK	TAPT1	151	Q6NXT6
PVCREEFRLSQALKE	ZNF142	256	P52746
PVVRQIDKQFLICSI	TRIM2	11	Q9C040
VVQAALCKPRQERVA	STK39	76	Q9UEW8
LCKPRQERVAIKRIN	STK39	81	Q9UEW8
LRPCELQRETAFLKQ	TG	31	P01266
QRVRELEKPIFCLKA	UNC13D	101	Q70J99
SSNEQLCFLVRPRIK	VPS33B	76	Q9H267
RVTLQCQKRDQLFVP	TARM1	141	B6A8C7
DFRVTCKDIQRIPSL	TSHR	36	P16473
CRPQDLLLVEAAVQK	ATP6V1E2	136	Q96A05
LTEPCRLKLQVERNL	VPS13D	2201	Q5THJ4
KRTVIEQQPVLCEVF	GGT1	181	P19440
CRKVLINNSLDEPRA	LRP4	1461	O75096
EELLQRCAQKSPRVA	MUS81	161	Q96NY9