Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR3	9.46e-05	4	80	2	GO:0005219
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR3	2.35e-04	6	80	2	GO:0048763
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	CDC42BPG PARP10 MB21D2 GNE RPS6KA5 PIK3C3 POLE RPS6KA1 PRKDC PIP4K2C POLQ ITPKA	3.40e-04	938	80	12	GO:0016772
GeneOntologyBiologicalProcess	lysosomal transport	SPTBN5 PIK3C3 HGSNAT VPS41 VPS16 RILP	2.32e-05	151	78	6	GO:0007041
GeneOntologyBiologicalProcess	response to calcium ion	ADAM9 ADGRV1 RYR1 RYR3 HTT ITPKA	3.33e-05	161	78	6	GO:0051592
GeneOntologyBiologicalProcess	vacuolar transport	SPTBN5 PIK3C3 HGSNAT VPS41 VPS16 RILP	7.66e-05	187	78	6	GO:0007034
GeneOntologyBiologicalProcess	retina homeostasis	ABCA4 POC1B BBS1 ADGRV1	1.01e-04	64	78	4	GO:0001895
GeneOntologyBiologicalProcess	response to radiation	FANCG ABCA4 NOG ASIC2 NLRP1 RIC8A PRKDC HTT SYNGAP1	1.16e-04	503	78	9	GO:0009314
GeneOntologyCellularComponent	AP-3 adaptor complex	AP3B2 VPS41 VPS16	1.50e-05	13	80	3	GO:0030123
MousePheno	increased susceptibility to malignant hyperthermia	RYR1 HTT	2.26e-05	2	67	2	MP:0020214
Domain	Ryanrecept_TM4-6	RYR1 RYR3	5.42e-05	3	80	2	IPR009460
Domain	RyR	RYR1 RYR3	5.42e-05	3	80	2	PF02026
Domain	Ryanodine_rcpt	RYR1 RYR3	5.42e-05	3	80	2	IPR003032
Domain	RR_TM4-6	RYR1 RYR3	5.42e-05	3	80	2	PF06459
Domain	Ryan_recept	RYR1 RYR3	5.42e-05	3	80	2	IPR013333
Domain	RIH_assoc	RYR1 RYR3	2.69e-04	6	80	2	PF08454
Domain	RIH_assoc-dom	RYR1 RYR3	2.69e-04	6	80	2	IPR013662
Domain	RIH_dom	RYR1 RYR3	2.69e-04	6	80	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR3	2.69e-04	6	80	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR3	2.69e-04	6	80	2	IPR015925
Domain	-	RYR1 RYR3	2.69e-04	6	80	2	1.25.10.30
Domain	RYDR_ITPR	RYR1 RYR3	2.69e-04	6	80	2	PF01365
Domain	Ribosomal_S6_kinase_II	RPS6KA5 RPS6KA1	2.69e-04	6	80	2	IPR016239
Domain	Ins145_P3_rec	RYR1 RYR3	2.69e-04	6	80	2	PF08709
Domain	Pkinase_C	CDC42BPG RPS6KA5 RPS6KA1	5.29e-04	37	80	3	IPR017892
Domain	ARM-type_fold	PIK3C3 AP3B2 RIC8A APOB PRKDC RYR3 HTT	6.23e-04	339	80	7	IPR016024
Domain	Pkinase_C	CDC42BPG RPS6KA5 RPS6KA1	7.70e-04	42	80	3	PF00433
Domain	MIR	RYR1 RYR3	7.97e-04	10	80	2	PS50919
Domain	MIR	RYR1 RYR3	7.97e-04	10	80	2	PF02815
Domain	MIR	RYR1 RYR3	7.97e-04	10	80	2	SM00472
Domain	MIR_motif	RYR1 RYR3	7.97e-04	10	80	2	IPR016093
Domain	HELICASE_CTER	ERCC6L HLTF DHX32 POLQ	1.23e-03	109	80	4	PS51194
Domain	HELICASE_ATP_BIND_1	ERCC6L HLTF DHX32 POLQ	1.23e-03	109	80	4	PS51192
Domain	Helicase_ATP-bd	ERCC6L HLTF DHX32 POLQ	1.28e-03	110	80	4	IPR014001
Domain	AGC-kinase_C	CDC42BPG RPS6KA5 RPS6KA1	1.78e-03	56	80	3	IPR000961
Domain	AGC_KINASE_CTER	CDC42BPG RPS6KA5 RPS6KA1	1.78e-03	56	80	3	PS51285
Domain	S_TK_X	CDC42BPG RPS6KA5 RPS6KA1	1.78e-03	56	80	3	SM00133
Domain	PI3/4_kinase_CS	PIK3C3 PRKDC	1.83e-03	15	80	2	IPR018936
Domain	Glyco_trans_31	B3GALNT1 B3GALT6	2.09e-03	16	80	2	IPR002659
Domain	Galactosyl_T	B3GALNT1 B3GALT6	2.09e-03	16	80	2	PF01762
Domain	-	PIK3C3 PRKDC	2.09e-03	16	80	2	1.10.1070.11
Domain	PI3Kc	PIK3C3 PRKDC	2.09e-03	16	80	2	SM00146
Domain	PI3/4_kinase_cat_dom	PIK3C3 PRKDC	2.65e-03	18	80	2	IPR000403
Domain	PI3_PI4_kinase	PIK3C3 PRKDC	2.65e-03	18	80	2	PF00454
Domain	PI3_4_KINASE_3	PIK3C3 PRKDC	2.65e-03	18	80	2	PS50290
Domain	PI3_4_KINASE_1	PIK3C3 PRKDC	2.65e-03	18	80	2	PS00915
Domain	PI3_4_KINASE_2	PIK3C3 PRKDC	2.65e-03	18	80	2	PS00916
Domain	Ank	NFKB2 ANKRD28 ANKRD50 BCOR ANKHD1	2.97e-03	228	80	5	PF00023
Domain	TPR-like_helical_dom	FANCG ERCC6L VPS41 PRKDC TTC22	3.26e-03	233	80	5	IPR011990
Domain	TPR-contain_dom	FANCG ERCC6L PRKDC TTC22	3.94e-03	150	80	4	IPR013026
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	CDC42BPG DIP2B ERCC6L POLE ADAM9 RPS6KA1 HLTF ANKRD28 ANKRD50 ANKHD1 ADCY6 QSOX2	4.13e-08	650	82	12	38777146
Pubmed	RILP interacts with HOPS complex via VPS41 subunit to regulate endocytic trafficking.	VPS41 VPS16 RILP	4.39e-07	7	82	3	25445562
Pubmed	mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.	PIK3C3 VPS16 RILP	3.55e-06	13	82	3	25533187
Pubmed	Resistance to inhibitors of cholinesterase (Ric)-8A and Gαi contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activity.	PIK3C3 RIC8A	5.49e-06	2	82	2	24466196
Pubmed	Principal mutation hotspot for central core disease and related myopathies in the C-terminal transmembrane region of the RYR1 gene.	RYR1 RYR3	5.49e-06	2	82	2	12565913
Pubmed	Contractile impairment and structural alterations of skeletal muscles from knockout mice lacking type 1 and type 3 ryanodine receptors.	RYR1 RYR3	5.49e-06	2	82	2	9489997
Pubmed	Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death.	RPS6KA5 HTT	5.49e-06	2	82	2	18029446
Pubmed	Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors.	RYR1 RYR3	5.49e-06	2	82	2	9192302
Pubmed	Loss-of-Function Variants in HOPS Complex Genes VPS16 and VPS41 Cause Early Onset Dystonia Associated with Lysosomal Abnormalities.	VPS41 VPS16	5.49e-06	2	82	2	32808683
Pubmed	The kinase MSK1 is required for induction of c-fos by lysophosphatidic acid in mouse embryonic stem cells.	RPS6KA5 RPS6KA1	5.49e-06	2	82	2	12769834
Pubmed	Mutations in CNTNAP1 and ADCY6 are responsible for severe arthrogryposis multiplex congenita with axoglial defects.	CNTNAP1 ADCY6	5.49e-06	2	82	2	24319099
Pubmed	The block of ryanodine receptors selectively inhibits fetal myoblast differentiation.	RYR1 RYR3	5.49e-06	2	82	2	12640042
Pubmed	Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle.	RYR1 RYR3	5.49e-06	2	82	2	7556644
Pubmed	Possible involvement of ryanodine receptor-mediated intracellular calcium release in the effect of corticotropin-releasing factor on adrenocorticotropin secretion.	RYR1 RYR3	5.49e-06	2	82	2	14592949
Pubmed	Differential localization of MAPK-activated protein kinases RSK1 and MSK1 in mouse brain.	RPS6KA5 RPS6KA1	5.49e-06	2	82	2	15893597
Pubmed	Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction.	RYR1 RYR3	5.49e-06	2	82	2	15894801
Pubmed	Morphological abnormalities of adrenal gland and hypertrophy of liver in mutant mice lacking ryanodine receptors.	RYR1 RYR3	5.49e-06	2	82	2	9799464
Pubmed	Effect of calmodulin on Ca2+-induced Ca2+ release of skeletal muscle from mutant mice expressing either ryanodine receptor type 1 or type 3.	RYR1 RYR3	5.49e-06	2	82	2	9817784
Pubmed	Expression and functional activity of ryanodine receptors (RyRs) during skeletal muscle development.	RYR1 RYR3	5.49e-06	2	82	2	17118445
Pubmed	RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle.	RYR1 RYR3	5.49e-06	2	82	2	11500519
Pubmed	JIP4 is a PLK1 binding protein that regulates p38MAPK activity in G2 phase.	ERCC6L ANKRD28 PRKDC	6.92e-06	16	82	3	26291670
Pubmed	ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.	PIK3C3 VPS41 VPS16	1.19e-05	19	82	3	33422265
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR3	1.64e-05	3	82	2	18403125
Pubmed	Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor.	RYR1 RYR3	1.64e-05	3	82	2	11171121
Pubmed	Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya.	RYR1 RYR3	1.64e-05	3	82	2	18313230
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR3	1.64e-05	3	82	2	18434746
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR3	1.64e-05	3	82	2	9204703
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR3	1.64e-05	3	82	2	7876312
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR3	1.64e-05	3	82	2	21881589
Pubmed	Loss of striatal 90-kDa ribosomal S6 kinase (Rsk) is a key factor for motor, synaptic and transcription dysfunction in Huntington's disease.	RPS6KA1 HTT	1.64e-05	3	82	2	27063456
Pubmed	UV-induced RPA phosphorylation is increased in the absence of DNA polymerase eta and requires DNA-PK.	PRKDC POLQ	1.64e-05	3	82	2	16520097
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR1 RYR3	1.64e-05	3	82	2	12213830
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR1 RYR3	1.64e-05	3	82	2	9242641
Pubmed	Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity.	RPS6KA1 HTT	1.64e-05	3	82	2	22041125
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR1 RYR3	1.64e-05	3	82	2	22948152
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR1 RYR3	1.64e-05	3	82	2	10788707
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR1 RYR3	1.64e-05	3	82	2	25239916
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR1 RYR3	1.64e-05	3	82	2	7621815
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR1 RYR3	1.64e-05	3	82	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR1 RYR3	1.64e-05	3	82	2	11159936
Pubmed	Increasing the Genetic Diagnosis Yield in Inherited Retinal Dystrophies: Assigning Pathogenicity to Novel Non-canonical Splice Site Variants.	ABCA4 POC1B	1.64e-05	3	82	2	32244552
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR1 RYR3	1.64e-05	3	82	2	10473538
Pubmed	Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor.	RIC8A ADCY6	1.64e-05	3	82	2	17593019
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR1 RYR3	1.64e-05	3	82	2	7959768
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR1 RYR3	1.64e-05	3	82	2	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR1 RYR3	1.64e-05	3	82	2	7635066
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	PPP1R7 DIP2B ADAM9 CNTNAP1 BTBD9 SYNGAP1	2.95e-05	251	82	6	27507650
Pubmed	Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.	RYR1 RYR3	3.28e-05	4	82	2	22100703
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR1 RYR3	3.28e-05	4	82	2	18206662
Pubmed	Adenylyl cyclase 6 plays a minor role in the mouse inner ear and retina.	ADGRV1 ADCY6	3.28e-05	4	82	2	37127773
Pubmed	An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha.	ESRRA HDAC8	3.28e-05	4	82	2	20484414
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR1 RYR3	3.28e-05	4	82	2	23413940
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR1 RYR3	3.28e-05	4	82	2	9384575
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR1 RYR3	3.28e-05	4	82	2	9607712
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR1 RYR3	3.28e-05	4	82	2	23482488
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	PPP1R7 EXOC5 ERCC6L POLE RPS6KA1 HLTF ANKRD28 PIP4K2C	3.81e-05	533	82	8	25544563
Pubmed	Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.	FANCG POLE PRKDC POLQ	4.80e-05	84	82	4	19237606
Pubmed	Adaptor protein-3 produces synaptic vesicles that release phasic dopamine.	AP3B2 VPS41	5.47e-05	5	82	2	37812725
Pubmed	The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells.	MMS22L PRKDC	5.47e-05	5	82	2	29478807
Pubmed	Fine mapping of Ath6, a quantitative trait locus for atherosclerosis in mice.	KCNS3 APOB	5.47e-05	5	82	2	11420610
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR1 RYR3	5.47e-05	5	82	2	23918386
Pubmed	Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha.	RPS6KA5 RPS6KA1	5.47e-05	5	82	2	10635333
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR1 RYR3	5.47e-05	5	82	2	19011160
Pubmed	Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC.	PARD6B NF2 RPS6KA1 HDAC8 B3GALT6 RIC8A	6.95e-05	293	82	6	31741433
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR1 RYR3	8.19e-05	6	82	2	19549818
Pubmed	Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b.	VPS41 VPS16	8.19e-05	6	82	2	21802320
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR1 RYR3	8.19e-05	6	82	2	26025922
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 RYR3	8.19e-05	6	82	2	23463619
Pubmed	Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers.	RYR1 RYR3	8.19e-05	6	82	2	10444070
Pubmed	FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.	RYR1 RYR3	8.19e-05	6	82	2	14592808
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 RYR3	8.19e-05	6	82	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 RYR3	8.19e-05	6	82	2	25966694
Pubmed	Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued.	RILP HTT	8.19e-05	6	82	2	18922795
Pubmed	Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1).	RPS6KA5 RPS6KA1	8.19e-05	6	82	2	12569367
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR1 RYR3	8.19e-05	6	82	2	19009018
Pubmed	Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.	RPS6KA5 RPS6KA1	8.19e-05	6	82	2	11297520
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 RYR3	8.19e-05	6	82	2	16844763
Pubmed	The small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes.	VPS41 RILP	8.19e-05	6	82	2	25908847
Pubmed	NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB.	NFKB2 PRKDC	8.19e-05	6	82	2	24892805
Pubmed	BBS mutations modify phenotypic expression of CEP290-related ciliopathies.	ABCA4 BBS1	1.14e-04	7	82	2	23943788
Pubmed	Improved Detection of in vivo Human NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Using a Novel NOG-FcγR-Deficient Human IL-15 Transgenic Mouse.	NOG PRKDC	1.14e-04	7	82	2	33117338
Pubmed	A genome-wide association study of carotid atherosclerosis in HIV-infected men.	NF2 RYR3	1.14e-04	7	82	2	20009918
Pubmed	Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.	RPS6KA5 RPS6KA1	1.14e-04	7	82	2	10880354
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR1 RYR3	1.14e-04	7	82	2	11860456
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	RYR1 RYR3	1.14e-04	7	82	2	20962236
Pubmed	SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery.	VPS41 VPS16	1.52e-04	8	82	2	19109425
Pubmed	Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes.	VPS41 VPS16	1.52e-04	8	82	2	25783203
Pubmed	Creation of a stress-activated p90 ribosomal S6 kinase. The carboxyl-terminal tail of the MAPK-activated protein kinases dictates the signal transduction pathway in which they function.	RPS6KA5 RPS6KA1	1.52e-04	8	82	2	10922375
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR1 RYR3	1.52e-04	8	82	2	19033399
Pubmed	Structural basis of Vps33A recruitment to the human HOPS complex by Vps16.	VPS41 VPS16	1.52e-04	8	82	2	23901104
Pubmed	Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors.	RYR1 RYR3	1.52e-04	8	82	2	21441923
Pubmed	Identification of the switch in early-to-late endosome transition.	VPS41 VPS16	1.52e-04	8	82	2	20434987
Pubmed	The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17.	VPS41 VPS16	1.52e-04	8	82	2	24554770
Pubmed	ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation.	RYR1 RYR3	1.52e-04	8	82	2	30563862
Pubmed	Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.	RYR1 RYR3	1.52e-04	8	82	2	11784029
Pubmed	Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation.	RPS6KA5 RPS6KA1	1.52e-04	8	82	2	16223362
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CDC42BPG DIP2B PARP10 NF2 PIK3C3 SLC16A14 HDAC8 VPS41 ADGRV1 BTBD9 VPS13B HTT	1.88e-04	1489	82	12	28611215
Pubmed	Phosphorylation of human microtubule-associated protein tau by protein kinases of the AGC subfamily.	RPS6KA5 RPS6KA1	1.96e-04	9	82	2	17512525
Pubmed	G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase.	KCNJ9 ADCY6	1.96e-04	9	82	2	12297500
Pubmed	Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy.	RYR1 RYR3	1.96e-04	9	82	2	21858002
Interaction	MTTP interactions	NF2 APOB PRKDC ADGRV1	9.42e-07	19	82	4	int:MTTP
Interaction	EEF1AKMT3 interactions	CDC42BPG RPS6KA5 ERCC6L POLE NFKB2 RTCA VPS41 DHX32 ANKHD1 VPS13B	2.20e-06	364	82	10	int:EEF1AKMT3
Interaction	PSG11 interactions	POLE NFKB2 RTCA DHX32 ANKHD1	4.90e-06	61	82	5	int:PSG11
Interaction	HOXC4 interactions	ANKRD28 PRKDC ANKHD1 HTT	2.53e-05	42	82	4	int:HOXC4
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR3	2.72e-05	3	55	2	287
GeneFamily	Mitogen-activated protein kinase-activated protein kinases	RPS6KA5 RPS6KA1	4.91e-04	11	55	2	1156
GeneFamily	Ankyrin repeat domain containing	NFKB2 ANKRD28 ANKRD50 BCOR ANKHD1	8.31e-04	242	55	5	403
GeneFamily	DNA polymerases	POLE POLQ	2.21e-03	23	55	2	535
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	PPP1R7 ANKRD28 PREX2 RYR1	2.23e-03	181	55	4	694
GeneFamily	Beta 3-glycosyltransferases	B3GALNT1 B3GALT6	2.40e-03	24	55	2	426
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	DIP2B EXOC5 PRKDC ADGRV1 ANKRD50 BCOR VPS13B	6.94e-08	193	82	7	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GALNT1 ABCA4 KCNJ9 NLRP1 SLC25A26	9.12e-06	152	82	5	b61d2f6ee819c8dd4b4b601a8bc8388b1983de58
ToppCell	droplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MMS22L ERCC6L POLE ANKRD28 POLQ	2.23e-05	183	82	5	6c1d7ce60e67bf1df364a4e177c351e7313eb41f
ToppCell	droplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating-classical_monocyte_proliferating_l33-52\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MMS22L ERCC6L POLE EML6 POLQ	2.35e-05	185	82	5	47c69500877b851c0c9744f5e1ef2ee0bff99168
ToppCell	droplet-Lung-21m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GALNT1 CRISPLD2 ABHD14A NOG KCNS3	2.60e-05	189	82	5	cd42ce4aa217d0bd95e0cc0ba357bdfeb3e55a48
ToppCell	droplet-Lung-21m-Mesenchymal-myofibroblast-myofibroblast_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GALNT1 CRISPLD2 ABHD14A NOG KCNS3	2.60e-05	189	82	5	102501eee7760d5882dec41ea9d00147b3f4fb73
ToppCell	343B-Lymphocytic-ILC\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	EXOC5 HGSNAT B3GALT6 ANKRD28 PIP4K2C	2.60e-05	189	82	5	c26428871dc3261327d89cacaba6e21e004ff1f3
ToppCell	droplet-Lung-21m-Mesenchymal-myofibroblast\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GALNT1 CRISPLD2 ABHD14A NOG KCNS3	2.60e-05	189	82	5	6e83bf855d4771885b60bb8992df2f9b508eef97
ToppCell	PCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	PARD6B ERCC6L CPM ADGRV1 POLQ	2.95e-05	194	82	5	c197e4acbff42a9f0410b6801c2bfcf6160aefc1
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Basal_3\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SPTBN5 AP3B2 TTC22 QSOX2 SYNGAP1	3.18e-05	197	82	5	4f8f23b1ef2eae9d300bd2c1a5cb7ef0163858a1
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX-Basal_3\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	SPTBN5 AP3B2 TTC22 QSOX2 SYNGAP1	3.18e-05	197	82	5	2cff37f9d33951840a8f52ccbba6ca1a4bbe3ad9
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Basal_3-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPTBN5 AP3B2 TTC22 QSOX2 SYNGAP1	3.18e-05	197	82	5	0f37afad46b94c748a149d9ee681472d7a3e6937
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-B-Plasmablast\|Leuk-UTI / Disease, condition lineage and cell class	PARD6B MB21D2 EML6 BBS1 POLQ	3.33e-05	199	82	5	1b17e6d5e6b994dec65efae2667f4f1f438161b1
Drug	5'-adenylyl (beta,gamma-methylene)diphosphonate	RYR1 RYR3	1.28e-05	2	82	2	ctd:C005147
Drug	AD 288	RPS6KA5 RPS6KA1 PRKDC	1.59e-05	14	82	3	CID000073553
Drug	cis-diammineplatinum(II	RYR1 RYR3	3.84e-05	3	82	2	CID000159790
Drug	2-hydroxyheptanoic acid	RYR1 RYR3	3.84e-05	3	82	2	CID002750949
Drug	8N3-cADPR	RYR1 RYR3	3.84e-05	3	82	2	CID000127713
Drug	aminodantrolene	RYR1 RYR3	3.84e-05	3	82	2	CID009570289
Drug	2-hydroxycarbazole	RYR1 RYR3	3.84e-05	3	82	2	CID000093551
Drug	1,1'-diheptyl-4,4'-bipyridinium	RYR1 RYR3	3.84e-05	3	82	2	CID000080262
Drug	flubendiamide	RYR1 RYR3	3.84e-05	3	82	2	CID011193251
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR1 RYR3	3.84e-05	3	82	2	CID005748312
Drug	indo-1/AM	ADGRV1 RYR1 RYR3	5.71e-05	21	82	3	CID000123918
Drug	Prednicarbate [73771-04-7]; Down 200; 8.2uM; PC3; HT_HG-U133A	NFKB2 VPS41 BBS1 PGPEP1 CPM VPS13B	7.04e-05	193	82	6	5119_DN
Drug	Methapyrilene hydrochloride [135-23-9]; Down 200; 13.4uM; MCF7; HT_HG-U133A	PPP1R7 NF2 RPS6KA5 ESRRA NFKB2 ANKRD28	7.24e-05	194	82	6	4990_DN
Drug	S(-)Eticlopride hydrochloride [97612-24-3]; Up 200; 10.6uM; PC3; HT_HG-U133A	TDRKH NF2 VPS41 PGPEP1 KCNS3 ADCY6	7.45e-05	195	82	6	4634_UP
Drug	A-30	RYR1 RYR3	7.65e-05	4	82	2	CID003028528
Drug	PCB74	RYR1 RYR3	7.65e-05	4	82	2	CID000036218
Drug	148504-47-6	RYR1 RYR3	7.65e-05	4	82	2	CID006444275
Drug	Bastadin 10	RYR1 RYR3	7.65e-05	4	82	2	CID009589366
Drug	SC 38249	RYR1 RYR3	7.65e-05	4	82	2	CID000134834
Drug	AC1L1U7A	RYR1 RYR3	7.65e-05	4	82	2	CID000035682
Drug	H2O2	PPP1R7 PARP10 FANCG NF2 RPS6KA5 PIK3C3 POLE NFKB2 NLRP1 KCNS3 POLQ ADCY6 RYR1 RYR3	7.75e-05	1183	82	14	CID000000784
Drug	Sulfisoxazole [127-69-5]; Down 200; 15uM; PC3; HT_HG-U133A	NID2 NF2 ESRRA CD101 KCNS3 RAPGEFL1	8.11e-05	198	82	6	4661_DN
Drug	gadolinium	NF2 ASIC2 B3GALT6 ADGRV1 RYR1 RYR3	8.34e-05	199	82	6	CID000023982
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR3	2.17e-05	3	80	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR3	2.17e-05	3	80	2	DOID:8545 (implicated_via_orthology)
Disease	azoospermia (implicated_via_orthology)	CDC42BPG TDRKH ESRRA	5.36e-05	27	80	3	DOID:14227 (implicated_via_orthology)
Disease	Cone-Rod Dystrophy 2	ABCA4 ADAM9 POC1B	6.66e-05	29	80	3	C3489532
Disease	lethal congenital contracture syndrome (is_implicated_in)	CNTNAP1 ADCY6	1.51e-04	7	80	2	DOID:0060558 (is_implicated_in)
Disease	Kidney Neoplasm	NF2 HLTF BCOR	1.76e-04	40	80	3	C0022665
Disease	Malignant neoplasm of kidney	NF2 HLTF BCOR	2.51e-04	45	80	3	C0740457
Disease	Disorder of eye	ABCA4 ADAM9 BBS1 ADGRV1 BCOR	2.83e-04	212	80	5	C0015397
Disease	Hernia	CRISPLD2 POC1B APOB	3.64e-04	51	80	3	HP_0100790
Disease	binge eating, bipolar disorder	APOB SLC25A26	5.55e-04	13	80	2	EFO_0005924, MONDO_0004985
Disease	common carotid intimal medial thickness	MMS22L APOB RYR3	8.11e-04	67	80	3	EFO_0004860
Disease	Fetal Alcohol Syndrome	ERCC6L RPS6KA1	9.61e-04	17	80	2	C0015923
Disease	uric acid measurement	CDC42BPG ANKRD28 KCNS3 SLC25A26 ADGRV1 ANKRD50 QSOX2	1.35e-03	610	80	7	EFO_0004761
Disease	Huntington's disease (is_implicated_in)	NOG HTT	1.77e-03	23	80	2	DOID:12858 (is_implicated_in)
Disease	ovarian carcinoma	MMS22L ABCA4 NLRP1 KCNS3 ADGRV1	1.82e-03	321	80	5	EFO_0001075
Disease	level of Sterol ester (27:1/16:0) in blood serum	APOB TTC22	2.26e-03	26	80	2	OBA_2045191
Disease	methionine measurement	ADGRV1 ANKHD1	2.26e-03	26	80	2	EFO_0009771
Disease	gastroesophageal reflux disease	MMS22L PGPEP1 APOB	2.64e-03	101	80	3	EFO_0003948

Protein segments in the cluster

Peptide	Gene	Start	Entry
HGDLLLLPALRDAYE	B3GALT6	116	Q96L58
LLLHAEGAQGDYVTL	CNTNAP1	211	P78357
DYVTLELEGAHLLLH	CNTNAP1	221	P78357
DAIDELLTGREHLYL	ABCA4	2021	P78363
IFDNYDLLLGVHGLA	ADCY6	861	O43306
GAFLDLLQHLGLEHY	GVINP1	856	Q7Z2Y8
HLLIILEDGIIEFYL	ADGRV1	1426	Q8WXG9
HAAAYLGDAEIIELL	ANKRD28	46	O15084
AYEGHVDVVDLLLEG	ANKRD50	756	Q9ULJ7
LGSYGVIILDDIHER	DHX32	176	Q7L7V1
DHLEIVRLLLSYGAD	BCOR	1541	Q6W2J9
ELLHRVAGEGLAVDY	AP3B2	861	Q13367
DLYHAGELLALLDVN	ASIC2	106	Q16515
DLESGLHYLLRVELA	QSOX2	326	Q6ZRP7
ELVYHLAGALGTELQ	RILP	26	Q96NA2
LIAYGRGDLEHLEDT	KCNJ9	81	Q92806
GLDGLLDLLLALHHE	CDC42BPG	21	Q6DT37
VDVLVGYADIHGDLL	PARD6B	56	Q9BYG5
ILYGELDHILARESL	ABHD14A	216	Q9BUJ0
LDGGNIDYVLETAHL	KLHL36	111	Q8N4N3
EDYAAHFLLGLIDDL	MB21D2	351	Q8IYB1
IDELHGLLLYIGHLS	MMS22L	171	Q6ZRQ5
LSLEDEHLLYGDIIR	B3GALNT1	131	O75752
LEKLGLGDSVDLHVY	PGPEP1	31	Q9NXJ5
IDLEKTLEAYGIHGL	NLRP1	651	Q9C000
IHYGILDDKGGLVDI	CRISPLD2	336	Q9H0B8
GALDETLELRGLRYH	DIP2B	1461	Q9P265
YHEVGLLLLFLSVGI	KCNS3	321	Q9BQ31
KLHLILDYINGGELF	RPS6KA5	126	O75582
LGALYSAEHGLLLEK	POLE	1526	Q07864
GDAAEHYLDLLALLL	FANCG	361	O15287
DLLEGRLIYTLQGHT	POC1B	256	Q8TC44
EDGYLLGLDNLIGIL	ITPKA	441	P23677
ELLLGVDALGLHIYD	NF2	231	P35240
LLSLHGSIIVGIDYD	NID2	1136	Q14112
YHLLGILAVVDIGLA	OR56B4	66	Q8NH76
DILYIGDHIFGDILK	NT5DC4	311	Q86YG4
IEHIDYALETGLAGI	EXOC5	456	O00471
YLRILGEELGFASLH	APOB	776	P04114
GALHGVLYVLECDLL	HTT	2781	P42858
LLVHLQHDGLLEYGE	CD101	861	Q93033
LDVVVLGSHLIDDYG	GNE	41	Q9Y223
ELLLHLIDYLVTSDG	CPM	91	P14384
LGDSHRGYLLELLLT	POLQ	221	O75417
LRGLLHLENASYGIE	ADAM9	136	Q13443
AAGYIDRLLLGDDHL	HGSNAT	466	Q68CP4
RLYLGHDDDILSLTI	EML6	721	Q6ZMW3
LATAYGLLELLVEGH	DCST2	36	Q5T1A1
GTVLAHYADVLGLLL	HLTF	696	Q14527
RILYVDLDLHHGDGV	HDAC8	171	Q9BY41
ILSEHIGALLIGEEY	BTBD9	21	Q96Q07
LALADLHGDGEYKLV	BBS1	41	Q8NFJ9
ELYLSHNGIEVIEGL	PPP1R7	256	Q15435
LGAYDRTHSLLLEVG	SLC25A26	256	Q70HW3
FSLLHRQYDGLGELL	RYR1	2121	P21817
LREALHEALLEYEAG	ESRRA	351	P11474
LDEHIAYLQSLGIAG	ERCC6L	656	Q2NKX8
LEGEIATYRHLLEGE	KRT36	386	O76013
RFLQLYHEDLLAGLG	PARP10	456	Q53GL7
YHEDLLAGLGDVALL	PARP10	461	Q53GL7
YSLLLGIHDIIRGSE	PIP4K2C	281	Q8TBX8
LNETLLRSLLGGHYD	NOG	61	Q13253
HGLVLLDLQSYDGDA	SMS	66	P52788
DLVGIEHLANAYGII	SLC16A14	431	Q7RTX9
TYILGVGDRHLDNLL	PIK3C3	736	Q8NEB9
DEEDAALYRHLGTLL	RIC8A	241	Q9NPQ8
EHTVGYGELLLLLSL	SLC35B1	166	P78383
YTELADGIHLLRLLE	SPTBN5	81	Q9NRC6
SGGYLDIVKLLLLHD	ANKHD1	281	Q8IWZ3
IALVHVDGHLYELDG	UCHL3	171	P15374
DIGLELVHKGYAIEL	TDRKH	481	Q9Y2W6
GYIDLGRELSTLHAL	SYNGAP1	681	Q96PV0
TGHYLALTEDQGLIL	RYR3	291	Q15413
LLANLRHGGTVDEYL	RTCA	281	O00442
ILLAVGPDLYLLDHA	VPS16	191	Q9H269
QDGHGLRYLLKEEDL	PREX2	1006	Q70Z35
DIGLAYINHLVERGD	VPS41	396	P49754
LEKVYELLGLLGEVH	PRKDC	171	P78527
VLLHELLNGYLNEEG	VPS13B	2256	Q7Z7G8
EEEGAGHIIKDLYLL	RAPGEFL1	236	Q9UHV5
LLEIRGYSKLHDDLG	SC5D	96	O75845
LDALIDDLDYLPGHF	TTC22	11	Q5TAA0
LALGLDHLHSLGIIY	RPS6KA1	171	Q15418
YELAGGDLAGLLEAL	NFKB2	821	Q00653