Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentsuper elongation complex

AFF1 AFF4

3.61e-056332GO:0032783
DomainTF_AF4/FMR2

AFF1 AFF4

1.81e-054332IPR007797
DomainAF-4

AFF1 AFF4

1.81e-054332PF05110
DomainARM-type_fold

DOCK5 HEATR5A THADA CLTCL1 WDFY4

2.99e-04339335IPR016024
DomainFA58C

CNTNAP5 DDR2

6.23e-0421332SM00231
DomainFA58C_3

CNTNAP5 DDR2

6.23e-0421332PS50022
DomainFA58C_1

CNTNAP5 DDR2

6.23e-0421332PS01285
DomainFA58C_2

CNTNAP5 DDR2

6.23e-0421332PS01286
DomainF5_F8_type_C

CNTNAP5 DDR2

8.15e-0424332PF00754
DomainFA58C

CNTNAP5 DDR2

8.15e-0424332IPR000421
Domain-

TANC1 CLTCL1 CFAP46

5.73e-032073331.25.40.10
Domain-

CNTNAP5 DDR2

7.36e-03733322.60.120.260
DomainTPR-like_helical_dom

TANC1 CLTCL1 CFAP46

7.94e-03233333IPR011990
DomainGalactose-bd-like

CNTNAP5 DDR2

1.20e-0294332IPR008979
Pubmed

Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription.

AFF1 AFF4

8.73e-07233226007649
Pubmed

Distinct roles of two SEC scaffold proteins, AFF1 and AFF4, in regulating RNA polymerase II transcription elongation.

AFF1 AFF4

8.73e-07233237528066
Pubmed

AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter.

AFF1 AFF4

8.73e-07233224843025
Pubmed

AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23).

AFF1 AFF4

2.62e-06333210588740
Pubmed

Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice.

AFF1 AFF4

5.23e-06433211923441
Pubmed

A Minor Subset of Super Elongation Complexes Plays a Predominant Role in Reversing HIV-1 Latency.

AFF1 AFF4

5.23e-06433226830226
Pubmed

Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4.

AFF1 AFF4

5.23e-06433225282333
Pubmed

Mediation of Af4 protein function in the cerebellum by Siah proteins.

AFF1 AFF4

5.23e-06433215459319
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

DOCK5 TRIM54 CRPPA CLTCL1 CPLANE1 MYL6B

1.20e-0555233610737800
Pubmed

The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin.

AFF1 AFF4

1.83e-05733215856011
Pubmed

Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2.

AFF1 AFF4

2.44e-05833232479599
Pubmed

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.

USP25 HEATR5A TANC1 RAPGEF6 VPS26B

2.73e-0537833534315543
Pubmed

Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure.

AFF1 AFF4

3.13e-05933224565118
Pubmed

A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription.

AFF1 AFF4

3.91e-051033220153263
Pubmed

HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP.

AFF1 AFF4

4.78e-051133220471949
Pubmed

AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation.

AFF1 AFF4

4.78e-051133224367103
Pubmed

The little elongation complex regulates small nuclear RNA transcription.

AFF1 AFF4

5.73e-051233222195968
Pubmed

Transcriptional and posttranscriptional regulation of HIV-1 gene expression.

AFF1 AFF4

6.77e-051333222355797
Pubmed

Transcriptional elongation factor ENL phosphorylated by ATM recruits polycomb and switches off transcription for DSB repair.

AFF1 AFF4

7.89e-051433225921070
Pubmed

MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia.

AFF1 AFF4

7.89e-051433220854876
Pubmed

A Survey of Essential Genome Stability Genes Reveals That Replication Stress Mitigation Is Critical for Peri-Implantation Embryogenesis.

GINS4 CDC25A

1.18e-041733232548123
Pubmed

Lost in transcription: molecular mechanisms that control HIV latency.

AFF1 AFF4

1.48e-041933223518577
Pubmed

Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia.

AFF1 AFF4

1.99e-042233216024815
Pubmed

The Role of RNA Polymerase II Elongation Control in HIV-1 Gene Expression, Replication, and Latency.

AFF1 AFF4

1.99e-042233222567366
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

DOCK5 AFF1 KMT2C THADA TANC1 RTEL1 AFF4

4.17e-04148933728611215
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

AFF1 KMT2C RAPGEF6 CPLANE1 WDFY4 AFF4

4.87e-04108433611544199
Pubmed

A microarray of ubiquitylated proteins for profiling deubiquitylase activity reveals the critical roles of both chain and substrate.

TRIM54 OTUB2

5.39e-043633222626734
Pubmed

USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.

DLD OTUB2

5.69e-043733232133736
Pubmed

A proteome-scale map of the SARS-CoV-2-human contactome.

USP25 TRIM54 CLTCL1

5.91e-0417333336217029
Pubmed

Characterization of the DOT1L network: implications of diverse roles for DOT1L.

AFF1 AFF4

7.00e-044133220431927
GeneFamilyAF4/FMR2 family|Super elongation complex

AFF1 AFF4

1.01e-0542421145
GeneFamilyAF4/FMR2 family|Super elongation complex

AFF1 AFF4

6.05e-0592421280
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

TANC1 CFAP46

1.01e-02115242769
ToppCellsevere-pDC|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ITM2C ZFAT WDFY4 MYL6B

1.35e-051983343c4820a8391088682fb3e47b914f872533bae227
ToppCellSepsis-Int-URO-Others-RBC|Int-URO / Disease, condition lineage and cell class

GINS4 ITM2C ZFAT MYL6B

1.35e-0519833429203aaa5c1844f72289e03f585cd5e7fc498a9a
ToppCellSepsis-Int-URO-Others|Int-URO / Disease, condition lineage and cell class

GINS4 ITM2C ZFAT MYL6B

1.35e-0519833467f721ea8e60042317ba12efd584f56b07cfb29d
ToppCellsevere-Plasmablast|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ITM2C CDC25A MYL6B DDR2

1.37e-051993346ee4c2e6049860071169366b7e662d5c1a3cc54b
ToppCellCOVID-19-COVID-19_Mild-Others-HSPC|COVID-19_Mild / Disease, condition lineage and cell class

CRPPA ITM2C HPGDS MYL6B

1.37e-051993340230103c37ae3aff58240739b89f2c36b1e39a69
ToppCellMS-IIF-Others-HSPC|IIF / Disease, condition lineage and cell class

ITM2C HPGDS ACOT13 MYL6B

1.37e-051993343384db80f6024bcabe2625f24d5f4e0d3d8caa7e
ToppCellMS-Multiple_Sclerosis-Others-HSPC|Multiple_Sclerosis / Disease, condition lineage and cell class

ITM2C CDC25A HPGDS MYL6B

1.37e-051993347f4a22207a8b27af9a070d289e31ebd0e57af1a6
ToppCellNS-critical-d_0-4-Myeloid-pDC|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ITM2C ZFAT CDC25A

1.63e-041443330fde5cd82df9b90aefde19275cff6c2ec3c9d5cb
ToppCellIIF-Lymphocyte-T_NK-dnT|IIF / Disease, Lineage and Cell Type

HPGDS MYL6B DDR2

1.70e-04146333d0f361662db5f7be26104346e8431f7e30c5ce3a
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Granulocytic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

OTUB2 WDFY4 HPGDS

1.95e-0415333383942ef63d21725fa15ed5a91481d1f9936e8f11
ToppCell356C-Myeloid-Dendritic-pDC|356C / Donor, Lineage, Cell class and subclass (all cells)

ITM2C THADA ZFAT

2.07e-04156333d9d87368e43b24952e70f31f38425e15b716ff5b
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-pDCs|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

ITM2C ZFAT WDFY4

2.15e-041583332af7beb48272e5368d9ba6b80f08d47ab8556c08
ToppCellCOVID_non-vent-Lymphocytic-Dendritic-pDC|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

ITM2C ZFAT WDFY4

2.23e-0416033361f4cb4eb4313d8318aadbb99595a6cb7fd919f7
ToppCellCOVID_non-vent-Lymphocytic-Dendritic|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

ITM2C ZFAT WDFY4

2.23e-0416033334b4f710cfcb6ec370b8b074f3cbfe272f392cec
ToppCellPND01-03-samps-Myeloid-Macrophage-CD163+_Macrophage|PND01-03-samps / Age Group, Lineage, Cell class and subclass

OTUB2 WDFY4 HPGDS

2.23e-041603334480a7d6bd48d06b4e5196faac868f31ab7ed3ad
ToppCellChildren_(3_yrs)-Immune-dendritic_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ITM2C ZFAT WDFY4

2.31e-0416233386a0b9dabd150dc993bfc0f3344804de7f8e4042
ToppCellNS-moderate-d_16-33-Myeloid-Mast_cell|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ITM2C RTEL1 HPGDS

2.39e-0416433335c673380f75cb4bfe080089bc723c4373bcc7a5
ToppCellMild-Myeloid-Mast-|Mild / Condition, Lineage, Cell class and cell subclass

TRIM54 TANC1 HPGDS

2.44e-0416533393d3909a0f5f43d473d5005c842d7d73e25eceed
ToppCellNS-critical-d_07-13-Myeloid-pDC|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ITM2C ZFAT WDFY4

2.44e-0416533317d5c4a111d9b5400780bc5e7b93ce2f5d69ceb7
ToppCellMild-Myeloid-Mast|Mild / Condition, Lineage, Cell class and cell subclass

TRIM54 TANC1 HPGDS

2.44e-041653335fa9552c37890c5cc7e672a47038aebba2413cb4
ToppCell343B-Lymphocytic-ILC|343B / Donor, Lineage, Cell class and subclass (all cells)

HEATR5A ITM2C CFAP46

2.48e-04166333a54377c703efff42d2cc1a8fdb610facc58053dd
ToppCellmild_COVID-19_(asymptomatic)-pDC|World / disease group, cell group and cell class (v2)

ITM2C ZFAT WDFY4

2.52e-04167333bf08f17965a4dd03f371b4ed0ab0d5e62ed61307
ToppCellmild_COVID-19_(asymptomatic)-pDC|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

ITM2C ZFAT WDFY4

2.57e-04168333968405ea56f7d001ef83ff9274610923c3b2d55d
ToppCellB_cells-pDCs|World / Immune cells in Kidney/Urine in Lupus Nephritis

ITM2C ZFAT WDFY4

2.57e-04168333dc8f94424f60ab56facdcffa969e7f3466ee1b6e
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITM2C ZFAT WDFY4

2.66e-0417033392e765ae0d3adb38d3b22fddb873fd5ccad3fd44
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITM2C ZFAT WDFY4

2.66e-041703339f8b215caa1afa3cd7104c06fca7cfd790640f66
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITM2C ZFAT WDFY4

2.66e-04170333b49f7c8a27078de2137ed04f74cfee30729cfa5e
ToppCell10x5'-blood-Myeloid_Dendritic-pDC|blood / Manually curated celltypes from each tissue

ITM2C ZFAT WDFY4

2.66e-0417033359cb1262ff319349d42b11afbec2a9035b7b79f2
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITM2C ZFAT WDFY4

2.71e-041713334fd2c7977c512c51507f055fc74b111c0228ed8b
ToppCellCOVID_vent-Lymphocytic-Dendritic-pDC|COVID_vent / Disease condition, Lineage, Cell class and subclass

ITM2C ZFAT WDFY4

2.71e-04171333779c951d274ecbd1d546ac425d6c8e718623be5a
ToppCellCOVID_vent-Lymphocytic-Dendritic|COVID_vent / Disease condition, Lineage, Cell class and subclass

ITM2C ZFAT WDFY4

2.71e-04171333debbb071d260639b16269c94d172766908325c58
ToppCell10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-eo/baso/mast_precursor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

CRPPA CNTNAP5 HPGDS

2.75e-041723337fb43b3938b9a3b6935ec22d9d853e7d47b82b3c
ToppCell10x3'2.3-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

CRPPA ITM2C HPGDS

2.80e-041733331e4afa020fae682521335b440ccd33c16f37156f
ToppCellwk_15-18-Hematologic-Myeloid-Eosinophil|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CRPPA CDC25A HPGDS

2.80e-04173333a85cead231e03945fabbc7762540ad21fe4299df
ToppCellnucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-pDC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ITM2C ZFAT WDFY4

2.90e-0417533337c2d4e0b6e9a3171931797ce9a54f3347288e57
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic-plasmacytoid_dendritic_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ITM2C ZFAT WDFY4

2.90e-0417533397fe431f224b592b3076632d101e19136c138dcc
ToppCellmild-Myeloid-pDC|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ITM2C ZFAT MYL6B

2.95e-0417633359a9c262c252b7d220a025837922d98e9d6b0a24
ToppCellControl-Myeloid-Mast|Myeloid / Disease state, Lineage and Cell class

ITM2C TANC1 HPGDS

2.95e-041763330c5916d63e1ada09105e46d2429b75129b7329ec
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITM2C ZFAT WDFY4

2.99e-04177333507f06d31ab773099c9431b6f433899dc97b5566
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITM2C ZFAT WDFY4

2.99e-041773338887ff6341eb070bdaa890cc2cd7745f0cf1b0af
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_prolif-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ZFAT WDFY4 HPGDS

3.04e-0417833330d2b54462fd16222ad2e3806be6143e834b29e0
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITM2C ZFAT WDFY4

3.09e-041793334808469096cd6bec2bdfcf4fc55aa324757600c3
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ITM2C ZFAT WDFY4

3.09e-04179333124da6f882968dc0d05f3edd8f3b4d61617cc214
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITM2C ZFAT WDFY4

3.09e-04179333c9f45cfea0ceb0cdc31bcfd123aeab69aeb35c35
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ITM2C ZFAT WDFY4

3.09e-04179333edc5ef693dc4e7ea70717b77fb908fc784dce3a2
ToppCellnormal_Lung-B_lymphocytes|normal_Lung / Location, Cell class and cell subclass

ITM2C ZFAT WDFY4

3.09e-041793335b89193486100b6754c1c5eca3105ea955805eae
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITM2C ZFAT WDFY4

3.09e-041793334d55718c6afd8a038d93cc77b9b08171dab9976f
ToppCellRSV-Healthy-0|RSV / Virus stimulation, Condition and Cluster

CRPPA CPLANE1 ACOT13

3.15e-04180333974044056e2f7e909cb11c6f6ca89e58bf95f7e5
ToppCellmild-Myeloid-pDC|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ITM2C ZFAT MYL6B

3.15e-0418033338614155fa537d0defda914c531c697be0ef06d8
ToppCellmoderate-Myeloid-pDC|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ITM2C ZFAT WDFY4

3.15e-04180333a0751ad5e42a21cb107d900abfa9ee967a0069fc
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITM2C ZFAT WDFY4

3.15e-041803336a2366d76276452141db1bd93013a9503525f574
ToppCellRSV-Healthy-0|Healthy / Virus stimulation, Condition and Cluster

CRPPA CPLANE1 ACOT13

3.15e-04180333703a1d0f9536af94d56757eb01221878d7b7fe61
ToppCellNS-moderate-d_16-33-Myeloid-pDC|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ITM2C ZFAT WDFY4

3.15e-04180333144818e69613296cde43f29cb8c20899c670b319
ToppCell18-Airway-Immune-Hematopoietic,_B_Cells|Airway / Age, Tissue, Lineage and Cell class

TRIM54 WDFY4 HPGDS

3.15e-04180333200cecbd8c12a4ec334583fdd5057397504de71e
ToppCellSevere-Lymphoid-pDC|Severe / Condition, Lineage, Cell class and cell subclass

ITM2C ZFAT WDFY4

3.20e-041813332caecb7c5dcdad46fd02b4ffb73cb613ce835187
ToppCelltumor_Lung-Myeloid_cells-pDCs|tumor_Lung / Location, Cell class and cell subclass

ITM2C ZFAT WDFY4

3.20e-04181333c864ffeb9234b8c29754afc91c85a972889617f4
ToppCellfacs-Spleen-nan-3m-Lymphocytic-Cd3e_T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TANC1 RAPGEF6 VPS26B

3.20e-04181333be7c7db6b99603759593e6f79cdcaa4bbf234cb7
ToppCellSevere-Lymphoid-pDC-|Severe / Condition, Lineage, Cell class and cell subclass

ITM2C ZFAT WDFY4

3.20e-04181333277ce4c49121da0990a5933b19d2c6af9bbe253e
ToppCellPBMC-Control-Hematopoietic-HSPC-HSPC-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ITM2C HPGDS MYL6B

3.25e-041823336497eeafb2b137e70261ec0314782831892a940d
ToppCellControl-Hematopoietic_SC-HSPC|Control / Disease group, lineage and cell class

ITM2C HPGDS MYL6B

3.25e-0418233314e347c0e6444410f1948851407bb18c706569f4
ToppCellControl-Hematopoietic_SC|Control / Disease group, lineage and cell class

ITM2C HPGDS MYL6B

3.25e-0418233343243c6bae2ac7fa3fd1f193a17f61ee4d938ea9
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIM54 ACOT13 MYL6B

3.25e-04182333c4a7007c864a9455a7e7447e28ccd380878a6a0f
ToppCellPBMC-Control-Hematopoietic-HSPC-HSPC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ITM2C HPGDS MYL6B

3.25e-04182333d0ebf2f0d5370458ab81485a0017c311077133d5
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Myeloid-pDC|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ITM2C ZFAT WDFY4

3.25e-0418233302c0824373a0ecebc922d4ca848ace9d570722c4
ToppCellPBMC-Control-Hematopoietic-HSPC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ITM2C HPGDS MYL6B

3.25e-04182333918286422b3eab32d962b49aa07b1b9512e51d9d
ToppCellPBMC-Control-Hematopoietic-HSPC|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ITM2C HPGDS MYL6B

3.25e-04182333bd1626261803324084fafca2f6665b50854e7fae
ToppCellPBMC-Control-Hematopoietic-HSPC-HSPC-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ITM2C HPGDS MYL6B

3.25e-041823332a6d1246bfb5899a0861c7f2f8fb9b43b0df8acc
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIM54 ACOT13 MYL6B

3.25e-04182333c315d820ffad912c014ba5eac6f5fa6de1a94384
ToppCellPBMC-Control-Hematopoietic-HSPC-HSPC|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ITM2C HPGDS MYL6B

3.25e-041823330d9b8c900da8cbae9cde72aecd4026b1ac2bbd67
ToppCellhematopoetic_progenitors-CD34+_MEP_2|World / Lineage and Cell class

CRPPA HPGDS MYL6B

3.25e-04182333a7e7aa10f14111a6c7ba22e0f1668dcaa124714d
ToppCellfacs-Heart-LA-3m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIM54 SLCO1B3 ACOT13

3.30e-04183333905e1e9be0f15be184447df04b134a6aa8279074
ToppCellfacs-Heart-LA-3m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIM54 SLCO1B3 ACOT13

3.30e-0418333392eed783347a372b850de3189e72525082390014
ToppCellfacs-Skin-Telogen-3m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TANC1 HPGDS DDR2

3.30e-04183333ed1e0b07475f9951728682ed70b85367cf2a744d
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ITM2C ZFAT WDFY4

3.30e-04183333df6fd0927b6e4cf9a1583969a68096e4bccfbace
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK5 CRPPA DDR2

3.30e-041833337eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK5 TRIM54 TANC1

3.30e-041833333c516fe5083f02bad1f464ed284010b4131a833c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK5 TRIM54 TANC1

3.30e-041833339c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCellnormal_Lung-B_lymphocytes-GrB-secreting_B_cells|normal_Lung / Location, Cell class and cell subclass

ITM2C ZFAT WDFY4

3.30e-04183333c930b957d16f9b0904b6c424acd914532e5cc137
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ITM2C ZFAT WDFY4

3.30e-041833333b123571e10c132227aff65648b4b3c6acb4bd00
ToppCell3'_v3-bone_marrow-Hematopoietic_progenitors-Progenitor_MEMP|bone_marrow / Manually curated celltypes from each tissue

GCGR CNTNAP5 HPGDS

3.35e-04184333b81a2a95944cee8fec13d63dc0d95496e67aa937
ToppCellsystemic_lupus_erythematosus-managed-Myeloid-plasmacytoid_dendritic_cell-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ITM2C ZFAT WDFY4

3.41e-04185333cc5152d3055375172bdf84f442b233c8fbd422b3
ToppCellnormal-na-Myeloid-plasmacytoid_dendritic_cell-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

ITM2C ZFAT WDFY4

3.41e-041853333091870a5bf8ecb963e560b47c8502bae367416c
ToppCellHealthy_donor-pDC|Healthy_donor / disease group, cell group and cell class (v2)

ITM2C ZFAT WDFY4

3.41e-041853337fbb55cbdb39bdecb6063c8ba9776ab06c2666e8
ToppCellBac-SEP-Myeloid-pDC|Bac-SEP / Disease, Lineage and Cell Type

ITM2C ZFAT MYL6B

3.41e-041853333de50b2042f22b0fb62ff12c76d85cc67649a0bd
ToppCellILEUM-inflamed-(3)_MNP-(3)_pDC|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

ITM2C ZFAT MYL6B

3.41e-04185333308a98f111895071d8772bc010554471cc12fab2
ToppCellhealthy_donor-Lymphocytic-Dendritic|healthy_donor / Disease condition, Lineage, Cell class and subclass

ITM2C ZFAT WDFY4

3.46e-04186333916f2aeea4989ba7a29e071e348a51010f010223
ToppCellcellseq-Immune-Immune_Myeloid-Myeloid_Dendritic-pDC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ITM2C ZFAT WDFY4

3.46e-04186333d23c3318937492d7d665bec14253124c49181b5a
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITM2C ZFAT WDFY4

3.46e-041863330096a61b1841784c913752b4f3639200446cc02c
ToppCellPBMC-Severe-Myeloid-pDC-pDC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ITM2C ZFAT WDFY4

3.46e-04186333b70cd94c651b56dcf2e55554533a5f1130845390
ToppCellPBMC-Severe-Myeloid-pDC-pDC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ITM2C ZFAT WDFY4

3.46e-0418633331df1eafa3010bc1be6fc4d4689f1393d69b6b13
ToppCellPBMC-Severe-Myeloid-pDC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ITM2C ZFAT WDFY4

3.46e-04186333eaa431ccd4cdd36fe06a44987603ec9979025aa8
ToppCellMultiple_Sclerosis-Myeloid-pDC|Multiple_Sclerosis / Disease, Lineage and Cell Type

ITM2C ZFAT WDFY4

3.46e-04186333330a4f669adea91ff9f2dff2de2210f5e3401e19
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITM2C ZFAT WDFY4

3.46e-041863339e159ad7289dcae2ec7ce655df746f46801b81d3
ToppCellCOVID-19_Severe-Myeloid-pDC|COVID-19_Severe / Disease group, lineage and cell class

ITM2C ZFAT WDFY4

3.46e-041863333db5ed69d49e5d79f990aca0295ddce4c297a05c
ToppCellPBMC-Severe-Myeloid-pDC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ITM2C ZFAT WDFY4

3.46e-04186333b95be984e308d4f9061274a35995ec558d434e74
ToppCellPBMC-Severe-Myeloid-pDC-pDC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ITM2C ZFAT WDFY4

3.46e-041863338f7949740286f64e034d1eb533ebc2c6f71ae966
ToppCellhealthy_donor-Lymphocytic-Dendritic-pDC|healthy_donor / Disease condition, Lineage, Cell class and subclass

ITM2C ZFAT WDFY4

3.46e-0418633345f66619e45d590c7365a51782d4ac46b7d31fde
ToppCellPBMC-Severe-Myeloid-pDC-pDC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ITM2C ZFAT WDFY4

3.46e-0418633395c7318e521fb6aa02e244b1e81e6b2a62107756
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITM2C ZFAT WDFY4

3.46e-041863336345777847960c71a2ba3ce5a49c72c34ebd0e73
ToppCellsystemic_lupus_erythematosus-flare-Myeloid-plasmacytoid_dendritic_cell-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ITM2C ZFAT WDFY4

3.52e-04187333d3563bb087e476baea5b59389e4d34d0ff98cac5
Diseaseresponse to risperidone

DOCK5 CNTNAP5

7.82e-0438322GO_0097336
Diseasenasopharynx carcinoma (is_marker_for)

KMT2C DDR2

1.00e-0343322DOID:9261 (is_marker_for)
Diseaseresponse to statin

CRPPA CNTNAP5

1.69e-0356322GO_0036273
Diseasebasophil measurement

AFF1 THADA

1.94e-0360322EFO_0803539
Diseasetestosterone measurement

DOCK5 SLCO1B3 AFF1 ITM2C THADA ACOT13

2.22e-031275326EFO_0004908
Diseasestomach cancer (is_implicated_in)

KMT2C DDR2

2.78e-0372322DOID:10534 (is_implicated_in)
Diseasemonocyte measurement

AFF1 THADA

3.58e-0382322EFO_0803547
Diseaseresponse to radiation

AFF1 TANC1

4.12e-0388322GO_0009314
Diseasemosquito bite reaction itch intensity measurement, mosquito bite reaction size measurement

ZFAT RAPGEF6 AFF4

5.32e-03328323EFO_0008377, EFO_0008378
Diseaselymphocyte percentage of leukocytes

DOCK5 AFF1 ITM2C THADA

5.57e-03665324EFO_0007993
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

AFF1 AFF4

5.80e-03105322DOID:9352 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
GKVICEMKVEEEHTN

ACOT13

36

Q9NPJ3
MDETHVINQVKEDVC

ACTR6

196

Q9GZN1
CQVHMEMAQIEEDED

CFAP46

426

Q8IYW2
GDVSCVDEILKEMTH

AFF4

311

Q9UHB7
CVVMDTEEDNKHVGH

CRPPA

286

A4D126
EEMDIKDFCTHEVEP

OTUB2

156

Q96DC9
HICGEDQIEDKMEVT

KMT2C

636

Q8NEZ4
EVHLCEVEGMEKFKD

DDR2

576

Q16832
TEMEQCHVDAIVDTL

HPGDS

81

O60760
CQMDGEEIEVQKEVA

GCGR

121

P47871
EMVVTEHVSDKEALG

ITM2C

201

Q9NQX7
VTCVDTMQEEEGDKG

HEATR5A

1181

Q86XA9
VMDITDIIHGKVDDE

DOCK5

326

Q9H7D0
EKDLEVEFDSCMIEH

CPLANE1

1306

Q9H799
MLAHKAEDEGIICVE

DLD

361

P09622
MEQLEAVIDGSEHCE

CNTNAP5

661

Q8WYK1
IKGAVNLHMEEEVED

CDC25A

396

P30304
VVIFDEAHNVEKMCE

RTEL1

246

Q9NZ71
DDLVACVESMHQVEE

THADA

1811

Q6YHU6
NTHKVEEEGEIVMVH

RAPGEF6

386

Q8TEU7
VECVMEQLEHMEENL

GINS4

51

Q9BRT9
VVQCLLGMEKEHEVE

TANC1

1056

Q9C0D5
LGMEKEHEVEVNGTD

TANC1

1061

Q9C0D5
DGEICEKGTHKELME

ABCC12

676

Q96J65
NEVHCVEEILKEMTH

AFF1

351

P51825
DVDCSEEVIKHLIMA

CLTCL1

821

P53675
EQHLMCEEHEEEKIN

TRIM54

121

Q9BYV2
SIKMEVGIEDCLHIE

VPS26B

161

Q4G0F5
VSEKHMEEGVNVDEI

ZFAT

31

Q9P243
KMTEEEVETVLAGHE

MYL6B

176

P14649
EIVEKDCVKESGSHM

SLCO1B3

156

Q9NPD5
KEVEKTEGDMTVQCH

WDFY4

2616

Q6ZS81
KDLHECLEAAMIEGE

USP25

331

Q9UHP3
HVPEQGDEKVCMDVF

TOPAZ1

1116

Q8N9V7