Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF620 ZNF12 ZKSCAN7 ZNF555 NRF1 ZNF544 LEF1 CASZ1 ZNF423 ZFP37 ZFP62 RBAK ZNF121 ZNF557	2.96e-07	1412	40	14	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF620 ZNF12 ZKSCAN7 ZNF555 NRF1 ZNF544 LEF1 CASZ1 ZNF423 ZFP37 ZFP62 RBAK ZNF121 ZNF557	4.42e-07	1459	40	14	GO:0000977
GeneOntologyMolecularFunction	benzodiazepine receptor activity	GABRA1 GABRA3	2.13e-04	11	40	2	GO:0008503
GeneOntologyMolecularFunction	GABA-gated chloride ion channel activity	GABRA1 GABRA3	5.87e-04	18	40	2	GO:0022851
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF12 ZKSCAN7 NRF1 ZNF544 LEF1 ZNF423 ZFP62 RBAK ZNF121	6.47e-04	1244	40	9	GO:0000978
GeneOntologyMolecularFunction	GABA-A receptor activity	GABRA1 GABRA3	6.55e-04	19	40	2	GO:0004890
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF12 ZKSCAN7 NRF1 ZNF544 LEF1 ZNF423 ZFP62 RBAK ZNF121	7.56e-04	1271	40	9	GO:0000987
GeneOntologyMolecularFunction	GABA receptor activity	GABRA1 GABRA3	8.81e-04	22	40	2	GO:0016917
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	GABRA1 GABRA3	1.05e-03	24	40	2	GO:0099507
GeneOntologyCellularComponent	GABA-A receptor complex	GABRA1 GABRA3	5.68e-04	19	39	2	GO:1902711
GeneOntologyCellularComponent	GABA receptor complex	GABRA1 GABRA3	6.96e-04	21	39	2	GO:1902710
Domain	zf-C2H2	ZNF620 ZNF12 ZKSCAN7 ZNF555 ZNF544 CASZ1 ZNF423 ZFP37 ZFP62 RBAK ZNF121 ZNF557	6.91e-09	693	38	12	PF00096
Domain	ZINC_FINGER_C2H2_2	ZNF620 ZNF12 ZKSCAN7 ZNF555 ZNF544 CASZ1 ZNF423 ZFP37 ZFP62 RBAK ZNF121 ZNF557	2.40e-08	775	38	12	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF620 ZNF12 ZKSCAN7 ZNF555 ZNF544 CASZ1 ZNF423 ZFP37 ZFP62 RBAK ZNF121 ZNF557	2.47e-08	777	38	12	PS00028
Domain	Znf_C2H2-like	ZNF620 ZNF12 ZKSCAN7 ZNF555 ZNF544 CASZ1 ZNF423 ZFP37 ZFP62 RBAK ZNF121 ZNF557	3.22e-08	796	38	12	IPR015880
Domain	Znf_C2H2	ZNF620 ZNF12 ZKSCAN7 ZNF555 ZNF544 CASZ1 ZNF423 ZFP37 ZFP62 RBAK ZNF121 ZNF557	3.64e-08	805	38	12	IPR007087
Domain	ZnF_C2H2	ZNF620 ZNF12 ZKSCAN7 ZNF555 ZNF544 CASZ1 ZNF423 ZFP37 ZFP62 RBAK ZNF121 ZNF557	3.80e-08	808	38	12	SM00355
Domain	-	ZNF620 ZNF12 ZKSCAN7 ZNF555 ZNF544 ZNF423 ZFP37 ZFP62 RBAK ZNF121 ZNF557	6.64e-08	679	38	11	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF620 ZNF12 ZKSCAN7 ZNF555 ZNF544 ZNF423 ZFP37 ZFP62 RBAK ZNF121 ZNF557	8.29e-08	694	38	11	IPR013087
Domain	KRAB	ZNF620 ZNF12 ZKSCAN7 ZNF555 ZNF544 ZFP37 RBAK ZNF557	4.99e-07	358	38	8	PS50805
Domain	KRAB	ZNF620 ZNF12 ZKSCAN7 ZNF555 ZNF544 ZFP37 RBAK ZNF557	4.99e-07	358	38	8	PF01352
Domain	KRAB	ZNF620 ZNF12 ZKSCAN7 ZNF555 ZNF544 ZFP37 RBAK ZNF557	6.27e-07	369	38	8	SM00349
Domain	KRAB	ZNF620 ZNF12 ZKSCAN7 ZNF555 ZNF544 ZFP37 RBAK ZNF557	6.40e-07	370	38	8	IPR001909
Domain	zf-C2H2_6	ZNF620 ZNF12 ZNF555 ZNF423 ZFP37 ZFP62 ZNF121	2.86e-06	314	38	7	PF13912
Domain	GABAAa_rcpt	GABRA1 GABRA3	6.02e-05	6	38	2	IPR001390
Domain	GABAA/Glycine_rcpt	GABRA1 GABRA3	9.93e-04	23	38	2	IPR006028
Domain	Neurotransmitter_ion_chnl_CS	GABRA1 GABRA3	3.78e-03	45	38	2	IPR018000
Domain	Neur_chan_memb	GABRA1 GABRA3	3.94e-03	46	38	2	PF02932
Domain	Neur_chan_LBD	GABRA1 GABRA3	4.11e-03	47	38	2	PF02931
Domain	Neur_channel	GABRA1 GABRA3	4.11e-03	47	38	2	IPR006201
Domain	Neur_chan_lig-bd	GABRA1 GABRA3	4.11e-03	47	38	2	IPR006202
Domain	NEUROTR_ION_CHANNEL	GABRA1 GABRA3	4.11e-03	47	38	2	PS00236
Domain	Neurotrans-gated_channel_TM	GABRA1 GABRA3	4.11e-03	47	38	2	IPR006029
Domain	-	GABRA1 GABRA3	4.11e-03	47	38	2	2.70.170.10
Pathway	BIOCARTA_FLUMAZENIL_PATHWAY	GABRA1 GABRA3	1.26e-04	9	27	2	M22034
Pathway	BIOCARTA_GABA_PATHWAY	GABRA1 GABRA3	1.57e-04	10	27	2	MM1401
Pathway	BIOCARTA_GABA_PATHWAY	GABRA1 GABRA3	1.57e-04	10	27	2	M477
Pubmed	Maintenance of recombinant type A gamma-aminobutyric acid receptor function: role of protein tyrosine phosphorylation and calcineurin.	GABRA1 GABRA3	1.29e-06	2	40	2	9655866
Pubmed	Altered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndrome.	GABRA1 GABRA3	1.29e-06	2	40	2	23744069
Pubmed	GABAA receptor subunits in the human amygdala and hippocampus: Immunohistochemical distribution of 7 subunits.	GABRA1 GABRA3	3.87e-06	3	40	2	29023704
Pubmed	Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons.	GABRA1 GABRA3	3.87e-06	3	40	2	16835366
Pubmed	The alpha 1, alpha 2, and alpha 3 subunits of GABAA receptors: comparison in seizure-prone and -resistant mice and during development.	GABRA1 GABRA3	3.87e-06	3	40	2	1356407
Pubmed	Transient expression of a GABA receptor subunit during early development is critical for inhibitory synapse maturation and function.	GABRA1 GABRA3	3.87e-06	3	40	2	34433078
Pubmed	Specific GABAA circuits for visual cortical plasticity.	GABRA1 GABRA3	3.87e-06	3	40	2	15017002
Pubmed	Analysis of the presence and abundance of GABAA receptors containing two different types of alpha subunits in murine brain using point-mutated alpha subunits.	GABRA1 GABRA3	3.87e-06	3	40	2	15304513
Pubmed	Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype.	GABRA1 GABRA3	7.73e-06	4	40	2	25865415
Pubmed	The α1, α2, α3, and γ2 subunits of GABAA receptors show characteristic spatial and temporal expression patterns in rhombencephalic structures during normal human brain development.	GABRA1 GABRA3	7.73e-06	4	40	2	26518133
Pubmed	Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.	GABRA1 GABRA3	7.73e-06	4	40	2	25080596
Pubmed	Altered GABA(A) receptor subunit expression and pharmacology in human Angelman syndrome cortex.	GABRA1 GABRA3	7.73e-06	4	40	2	20692323
Pubmed	GABA(A) receptor downregulation in brains of subjects with autism.	GABRA1 GABRA3	7.73e-06	4	40	2	18821008
Pubmed	Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors.	GABRA1 GABRA3	1.29e-05	5	40	2	30104684
Pubmed	GABAA receptor signaling in caudal periaqueductal gray regulates maternal aggression and maternal care in mice.	GABRA1 GABRA3	1.93e-05	6	40	2	20457185
Pubmed	Modelling extracellular domains of GABA-A receptors: subtypes 1, 2, 3, and 5.	GABRA1 GABRA3	1.93e-05	6	40	2	15033447
Pubmed	Attack behaviors in mice: from factorial structure to quantitative trait loci mapping.	GABRA1 GABRA3	1.93e-05	6	40	2	16266699
Pubmed	Lamina-specific alterations in cortical GABA(A) receptor subunit expression in schizophrenia.	GABRA1 GABRA3	2.70e-05	7	40	2	20843900
Pubmed	Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO).	GABRA1 GABRA3	2.70e-05	7	40	2	35228700
Pubmed	Developmental changes in GABA receptor subunit composition within the gonadotrophin-releasing hormone-1 neuronal system.	GABRA1 GABRA3	2.70e-05	7	40	2	16101898
Pubmed	Poor replication of candidate genes for major depressive disorder using genome-wide association data.	PDE10A CCKAR GABRA3	2.82e-05	51	40	3	20351714
Pubmed	gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties.	GABRA1 GABRA3	3.60e-05	8	40	2	8175718
Pubmed	Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation.	GABRA1 GABRA3	3.60e-05	8	40	2	18185516
Pubmed	GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1.	GABRA1 GABRA3	3.60e-05	8	40	2	11528422
Pubmed	Inhibitory synapse dysfunction and epileptic susceptibility associated with KIF2A deletion in cortical interneurons.	GABRA1 GABRA3	5.77e-05	10	40	2	36733270
Pubmed	Functional modifications of acid-sensing ion channels by ligand-gated chloride channels.	GABRA1 GABRA3	5.77e-05	10	40	2	21789198
Pubmed	Review: Central non-glucocorticoid inhibitors of the hypothalamo-pituitary-adrenal axis.	GABRA1 GABRA3	7.05e-05	11	40	2	9924185
Pubmed	Region and layer-specific expression of GABAA receptor isoforms and KCC2 in developing cortex.	GABRA1 GABRA3	7.05e-05	11	40	2	38894703
Pubmed	Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease.	GABRA1 GABRA3	8.45e-05	12	40	2	2561974
Pubmed	Involvement of neurotransmitters in the action of growth hormone-releasing hormone antagonist on passive avoidance learning.	GABRA1 GABRA3	9.98e-05	13	40	2	22640814
Pubmed	Neurotransmitter-mediated action of an antagonist of growth hormone-releasing hormone on anxiolysis in mice.	GABRA1 GABRA3	9.98e-05	13	40	2	22569571
Pubmed	Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.	CCKAR GABRA1 GABRA3	1.13e-04	81	40	3	22723691
Pubmed	The biochemical anatomy of cortical inhibitory synapses.	GABRA1 GABRA3	1.16e-04	14	40	2	22768092
Pubmed	Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis.	OR10H3 ZNF423	1.53e-04	16	40	2	17521568
Pubmed	The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map.	LEF1 FAT3 CCKAR	1.76e-04	94	40	3	23431145
Pubmed	GABA neurotransmitter signaling in the developing mouse lens: dynamic regulation of components and functionality.	GABRA1 GABRA3	1.95e-04	18	40	2	18985723
Pubmed	Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.	GABRA1 GABRA3	1.95e-04	18	40	2	19078961
Pubmed	Early growth response 1 (Egr-1) directly regulates GABAA receptor α2, α4, and θ subunits in the hippocampus.	GABRA1 GABRA3	2.67e-04	21	40	2	25708312
Pubmed	Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders.	GABRA1 GABRA3	2.94e-04	22	40	2	35245678
Pubmed	Chromosomal localization of the genes for five zinc finger proteins expressed in mouse lens.	ZFP62 GABRA1	2.94e-04	22	40	2	7590745
Pubmed	Extension of conserved regions in the rat and mouse genomes by chromosomal assignments of 29 rat genes.	CCKAR GABRA3	3.50e-04	24	40	2	9606417
Pubmed	Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.	LEF1 DPEP3	4.12e-04	26	40	2	19060910
Pubmed	A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.	CFAP251 TMEM120B	7.07e-04	34	40	2	24026423
Pubmed	Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity.	MUC2 LEF1	7.93e-04	36	40	2	27736991
Interaction	ZNF473 interactions	ZNF12 ZNF423 ZFP37 ZFP62 RBAK	8.43e-08	56	40	5	int:ZNF473
Interaction	ZNF710 interactions	ZNF423 ZFP37 ZFP62 RBAK	3.51e-07	30	40	4	int:ZNF710
Interaction	ZFP3 interactions	ZNF423 ZFP37 ZFP62 RBAK	3.51e-07	30	40	4	int:ZFP3
Interaction	ZNF382 interactions	ZNF423 ZFP37 ZFP62 RBAK	5.22e-07	33	40	4	int:ZNF382
Interaction	RBAK interactions	ZNF423 ZFP37 ZFP62 RBAK ZNF121	5.45e-07	81	40	5	int:RBAK
Interaction	ZNF513 interactions	ZNF423 ZFP37 ZFP62 RBAK	5.91e-07	34	40	4	int:ZNF513
Interaction	ZNF652 interactions	ZNF423 ZFP37 ZFP62 RBAK	6.66e-07	35	40	4	int:ZNF652
Interaction	ZFP28 interactions	ZNF423 ZFP37 ZFP62 RBAK	8.38e-07	37	40	4	int:ZFP28
Interaction	ZFP37 interactions	ZNF423 ZFP37 ZFP62 RBAK	2.64e-06	49	40	4	int:ZFP37
Interaction	ZNF667 interactions	ZNF423 ZFP37 ZFP62 RBAK	3.63e-06	53	40	4	int:ZNF667
Interaction	ZSCAN21 interactions	ZKSCAN7 ZNF423 ZFP37 ZFP62 RBAK	5.26e-06	128	40	5	int:ZSCAN21
Interaction	ZNF287 interactions	ZNF423 ZFP37 ZFP62 RBAK	5.99e-06	60	40	4	int:ZNF287
Interaction	CTCFL interactions	ZNF423 ZFP37 ZFP62 RBAK	6.83e-06	62	40	4	int:CTCFL
Interaction	ZNF787 interactions	ZNF423 ZFP37 ZFP62 RBAK	7.76e-06	64	40	4	int:ZNF787
Interaction	ZNF423 interactions	ZNF423 ZFP37 ZFP62 RBAK	1.31e-05	73	40	4	int:ZNF423
Interaction	PRDM5 interactions	TYK2 ZNF423 ZFP37 ZFP62	1.89e-05	80	40	4	int:PRDM5
Interaction	MYNN interactions	ZNF423 ZFP37 ZFP62	3.45e-05	32	40	3	int:MYNN
Interaction	GABRA5 interactions	GABRA1 GABRA3	3.83e-05	5	40	2	int:GABRA5
Interaction	GLI3 interactions	ZNF423 ZFP37 ZFP62 RBAK	4.20e-05	98	40	4	int:GLI3
Interaction	ZFP62 interactions	ZNF423 ZFP37 ZFP62 RBAK	4.37e-05	99	40	4	int:ZFP62
Interaction	PRDM4 interactions	ZNF423 ZFP37 RBAK	1.50e-04	52	40	3	int:PRDM4
Interaction	ZNF768 interactions	ZNF423 ZFP37 ZFP62 RBAK	2.24e-04	151	40	4	int:ZNF768
Interaction	ZBTB48 interactions	ZNF423 ZFP37 ZFP62 ZNF121	2.67e-04	158	40	4	int:ZBTB48
Interaction	ZNF8 interactions	ZNF423 ZFP37 ZFP62	3.62e-04	70	40	3	int:ZNF8
Interaction	ZNF24 interactions	ZNF620 ZFP37 ZFP62 RBAK	3.85e-04	174	40	4	int:ZNF24
Interaction	ZBTB17 interactions	ZNF423 ZFP37 ZFP62	4.79e-04	77	40	3	int:ZBTB17
Interaction	LTBP2 interactions	ZNF12 ZNF555 RBAK	6.39e-04	85	40	3	int:LTBP2
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	TYK2 C3P1 ZNF555 OR7A17 OR10H3 ZNF121 ZNF557	5.24e-06	797	40	7	chr19p13
Cytoband	7p22.1	ZNF12 RBAK	7.81e-04	47	40	2	7p22.1
Cytoband	19p13.2	TYK2 C3P1 ZNF557	1.06e-03	229	40	3	19p13.2
Cytoband	12q24.31	CFAP251 TMEM120B	2.24e-03	80	40	2	12q24.31
Cytoband	Ensembl 112 genes in cytogenetic band chr7p22	ZNF12 RBAK	6.13e-03	134	40	2	chr7p22
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF620 ZNF12 ZKSCAN7 ZNF555 ZNF544 CASZ1 ZNF423 ZFP37 ZFP62 RBAK ZNF121 ZNF557	3.92e-10	718	29	12	28
GeneFamily	Gamma-aminobutyric acid type A receptor subunits	GABRA1 GABRA3	4.18e-04	19	29	2	563
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_MedNas_2500_K1	KIAA1549L PDE10A LEF1 GIN1 ZNF423 ZFP37 FAT3 KIF11 GABRA1 GABRA3	7.13e-06	1060	36	10	facebase_RNAseq_e10.5_Emin_MedNas_2500_K1
ToppCell	E15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ZKSCAN7 KIAA1549L MUC2 RBAK GABRA1	2.63e-07	154	40	5	e65e4636646164610f33f7bbac0d879a3ea55986
ToppCell	droplet-Liver-Hepatocytes-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC160 TMEM120B PDE10A INPP5K GABRA3	6.52e-07	185	40	5	60206c7322b4ddb2010040aac70561df842c9843
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ADAMTS6 LEF1 CASZ1 FAT3 KIF11	7.44e-07	190	40	5	e83fa8b711aa79a1767818474f1c193b674b1c31
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)-D231\|Adult / Lineage, Cell type, age group and donor	PDE10A ADAMTS6 CASZ1 ZNF423	2.25e-05	185	40	4	07f9f38f0739d7c830641723a38385550ac1ac92
ToppCell	droplet-Liver-Hepatocytes-21m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC160 PDE10A INPP5K GABRA3	2.25e-05	185	40	4	efcfbf5a48b3ea9a425183e5c2eec6a9585415a0
ToppCell	droplet-Liver-Hepatocytes-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC160 PDE10A INPP5K GABRA3	2.25e-05	185	40	4	642088ace9230d38b0579853c54ff4dd8b5d5df4
ToppCell	Control-Endothelial-Endothelial-Vein\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KIAA1549L PDE10A ADAMTS6 ZNF423	2.30e-05	186	40	4	92092f11ecce22c14f244e42c499af0822977e6f
ToppCell	COVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	KIAA1549L PDE10A ADAMTS6 ZNF423	2.35e-05	187	40	4	2d20193a6cacdfa4877457c97b0077408942186c
ToppCell	Endothelial-endothelial_cell_of_artery\|World / Lineage, Cell type, age group and donor	KIAA1549L PDE10A ADAMTS6 ZNF423	2.45e-05	189	40	4	fdd89c71113ac99b7c800c6def8888e512ff1128
ToppCell	Bronchial-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_venous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KIAA1549L PDE10A ADAMTS6 ZNF423	3.00e-05	199	40	4	3a4deea6e11a0555d27497b7c9983350797aac69
ToppCell	Sepsis-Bac-SEP-Lymphocyte-T/NK-NK_CD56bright\|Bac-SEP / Disease, condition lineage and cell class	ZNF620 TMEM120B LEF1 DPEP3	3.05e-05	200	40	4	ebab762fe5209c23c5a9ac9281f728fafa433af3
Drug	Zolpidem	GABRA1 GABRA3	9.02e-06	3	40	2	DB00425
Drug	Flumazenil	GABRA1 GABRA3	1.80e-05	4	40	2	DB01205
Drug	Eszopiclone	GABRA1 GABRA3	3.00e-05	5	40	2	DB00402
Drug	Zopiclone	GABRA1 GABRA3	3.00e-05	5	40	2	DB01198
Drug	Lorazepam	GABRA1 GABRA3	3.00e-05	5	40	2	ctd:D008140
Drug	DMCM	CCKAR GABRA1 GABRA3	4.06e-05	38	40	3	CID000104999
Drug	Meprobamate	GABRA1 GABRA3	4.49e-05	6	40	2	DB00371
Drug	Quazepam	GABRA1 GABRA3	6.28e-05	7	40	2	DB01589
Drug	Adinazolam	GABRA1 GABRA3	8.37e-05	8	40	2	DB00546
Drug	Fludiazepam	GABRA1 GABRA3	8.37e-05	8	40	2	DB01567
Drug	Clotiazepam	GABRA1 GABRA3	8.37e-05	8	40	2	DB01559
Drug	Cinolazepam	GABRA1 GABRA3	8.37e-05	8	40	2	DB01594
Drug	Prazepam	GABRA1 GABRA3	8.37e-05	8	40	2	DB01588
Drug	Estazolam	GABRA1 GABRA3	8.37e-05	8	40	2	DB01215
Drug	Halazepam	GABRA1 GABRA3	8.37e-05	8	40	2	DB00801
Drug	1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane	GABRA1 GABRA3	8.37e-05	8	40	2	ctd:C091518
Drug	tiotidine	GABRA1 GABRA3	1.08e-04	9	40	2	ctd:C023990
Drug	Ethchlorvynol	GABRA1 GABRA3	1.08e-04	9	40	2	DB00189
Drug	AC1L18T4	CRAT INPP5K	1.08e-04	9	40	2	CID000000246
Drug	Diazepam	GABRA1 GABRA3	1.08e-04	9	40	2	DB00829
Drug	Secobarbital	GABRA1 GABRA3	1.34e-04	10	40	2	DB00418
Drug	Chlordiazepoxide	GABRA1 GABRA3	1.34e-04	10	40	2	DB00475
Drug	Metharbital	GABRA1 GABRA3	1.34e-04	10	40	2	DB00463
Drug	Pentobarbital	GABRA1 GABRA3	1.34e-04	10	40	2	DB00312
Drug	Talbutal	GABRA1 GABRA3	1.34e-04	10	40	2	DB00306
Drug	Clobazam	GABRA1 GABRA3	1.34e-04	10	40	2	DB00349
Drug	Butalbital	GABRA1 GABRA3	1.34e-04	10	40	2	DB00241
Drug	Butabarbital	GABRA1 GABRA3	1.34e-04	10	40	2	DB00237
Drug	Bromazepam	GABRA1 GABRA3	1.34e-04	10	40	2	DB01558
Drug	Barbituric acid derivative	GABRA1 GABRA3	1.34e-04	10	40	2	DB01496
Drug	Barbital	GABRA1 GABRA3	1.34e-04	10	40	2	DB01483
Drug	Hexobarbital	GABRA1 GABRA3	1.34e-04	10	40	2	DB01355
Drug	Aprobarbital	GABRA1 GABRA3	1.34e-04	10	40	2	DB01352
Drug	Amobarbital	GABRA1 GABRA3	1.34e-04	10	40	2	DB01351
Drug	Heptabarbital	GABRA1 GABRA3	1.34e-04	10	40	2	DB01354
Drug	Butethal	GABRA1 GABRA3	1.34e-04	10	40	2	DB01353
Drug	Clonazepam	GABRA1 GABRA3	1.34e-04	10	40	2	DB01068
Drug	Methylphenobarbital	GABRA1 GABRA3	1.34e-04	10	40	2	DB00849
Drug	Oxazepam	GABRA1 GABRA3	1.34e-04	10	40	2	DB00842
Drug	Primidone	GABRA1 GABRA3	1.34e-04	10	40	2	DB00794
Drug	Midazolam	GABRA1 GABRA3	1.34e-04	10	40	2	DB00683
Drug	Flurazepam	GABRA1 GABRA3	1.34e-04	10	40	2	DB00690
Drug	Thiopental	GABRA1 GABRA3	1.64e-04	11	40	2	DB00599
Drug	Alprazolam	GABRA1 GABRA3	1.64e-04	11	40	2	DB00404
Drug	Temazepam	GABRA1 GABRA3	1.64e-04	11	40	2	DB00231
Drug	Nitrazepam	GABRA1 GABRA3	1.64e-04	11	40	2	DB01595
Drug	Lorazepam	GABRA1 GABRA3	1.64e-04	11	40	2	DB00186
Drug	Phenobarbital	GABRA1 GABRA3	1.64e-04	11	40	2	DB01174
Drug	Triazolam	GABRA1 GABRA3	1.64e-04	11	40	2	DB00897
Drug	Clorazepate	GABRA1 GABRA3	1.64e-04	11	40	2	DB00628
Drug	Ciclopirox ethanolamine [41621-49-2]; Up 200; 15uM; HL60; HT_HG-U133A	SPTLC3 PIGA CRAT ZNF557	2.43e-04	174	40	4	2456_UP
Drug	methylclofenapate	CRAT INPP5K	3.56e-04	16	40	2	CID000030602
Drug	phentolamine; Down 200; 11.5uM; MCF7; HT_HG-U133A_EA	PIGA NRF1 INPP5K DMXL1	3.75e-04	195	40	4	1138_DN
Drug	Delcorine; Down 200; 8.4uM; PC3; HT_HG-U133A	MANBA NRF1 LEF1 CASZ1	3.75e-04	195	40	4	3715_DN
Drug	Trapidil [15421-84-8]; Down 200; 19.4uM; HL60; HT_HG-U133A	SPTLC3 TMEM120B NRF1 INPP5K	3.82e-04	196	40	4	3136_DN
Drug	Alfuzosin hydrochloride [81403-68-1]; Up 200; 9.4uM; MCF7; HT_HG-U133A	SPTLC3 PDE10A NRF1 CRAT	3.89e-04	197	40	4	5242_UP
Drug	LY 294002; Up 200; 0.1uM; MCF7; HT_HG-U133A	TYK2 SPTLC3 CASZ1 ZFP37	3.97e-04	198	40	4	6976_UP
Drug	Scopolamine hydrochloride [55-16-3]; Up 200; 11.8uM; HL60; HT_HG-U133A	CRAT LEF1 ZNF423 INPP5K	3.97e-04	198	40	4	3018_UP
Drug	SB 203580; Down 200; 1uM; PC3; HT_HG-U133A	SPTLC3 NRF1 CASZ1 INPP5K	3.97e-04	198	40	4	7066_DN
Drug	Felbinac [5728-52-9]; Down 200; 18.8uM; MCF7; HT_HG-U133A	TMEM120B CRAT ZNF423 ZFP37	3.97e-04	198	40	4	3398_DN
Drug	Griseofulvin [126-07-8]; Down 200; 11.2uM; PC3; HT_HG-U133A	KIAA1549L NRF1 CASZ1 INPP5K	3.97e-04	198	40	4	7363_DN
Drug	Indapamide [26807-65-8]; Up 200; 10.6uM; MCF7; HT_HG-U133A	SPTLC3 MUC2 LEF1 CCKAR	3.97e-04	198	40	4	3970_UP
Drug	SR 27897	ZKSCAN7 CCKAR	4.03e-04	17	40	2	CID000122077
Drug	dihydroxyaflavinine	GABRA1 GABRA3	4.03e-04	17	40	2	CID000156857
Drug	Gelsemine [509-15-9]; Up 200; 12.4uM; MCF7; HT_HG-U133A	OR7A17 PDE10A MUC2 CCKAR	4.05e-04	199	40	4	4177_UP
Disease	4-ethylphenylsulfate measurement	NRF1 ADAMTS6 LEF1	1.59e-06	18	38	3	EFO_0021148
Disease	primary aldosteronism	CASZ1 CCKAR	5.15e-04	26	38	2	MONDO_0001422
Disease	Hepatic fibrosis	DNAAF9 KIAA1549L	1.83e-03	49	38	2	HP_0001395
Disease	Crohn Disease	TYK2 MUC2	1.90e-03	50	38	2	C0010346
Disease	obesity (implicated_via_orthology)	TYK2 LEF1 CCKAR	2.67e-03	215	38	3	DOID:9970 (implicated_via_orthology)
Disease	sarcoidosis	TYK2 MANBA	3.10e-03	64	38	2	MONDO_0019338
Disease	Bipolar Disorder	PDE10A CCKAR GABRA1 GABRA3	3.22e-03	477	38	4	C0005586
Disease	Alcohol abuse	CCKAR GABRA1	3.39e-03	67	38	2	C0085762
Disease	Antihypertensive use measurement	PDE10A LEF1 CASZ1	4.79e-03	265	38	3	EFO_0009927
Disease	Alcoholic Intoxication, Chronic	PDE10A CCKAR GABRA1	4.94e-03	268	38	3	C0001973

Protein segments in the cluster

Peptide	Gene	Start	Entry
TYARTHTHSVFMSSN	nan	11	Q6ZS92
VYTSTSDVMTHENFH	CASZ1	561	Q86V15
TSYAIAMHFHLSTSQ	CRAT	541	P43155
ASLSRFSYSHMSASV	CCKAR	411	P32238
RHFGSSDTFSTHMSL	DMXL1	1826	Q9Y485
MASSEFHSDHRLSYS	ADAMTS6	16	Q9UKP5
VTHISFSHDSQYMAT	CFAP251	696	Q8TBY9
SSLSVDTSMSRFSHH	LEF1	231	Q9UJU2
TLMNAYSSRSHSVFS	KIF11	226	P52732
YSSRSHSVFSVTIHM	KIF11	231	P52732
SFSVFRPSSYHIMVS	MUC2	481	Q02817
YSTSTMEQHHFSQTV	PDE10A	576	Q9Y233
QVHVATYTEHSMLSA	NRF1	26	Q16656
RSSTGEYVVMTTHFH	GABRA3	256	P34903
QSSTGEYVVMTTHFH	GABRA1	231	P14867
PTYMYARTGHTTSTH	KIAA1549L	711	Q6ZVL6
STCVSHLTVVVMHYS	OR10H3	241	O60404
HYSKSDTQTHTMFLA	PARP12	606	Q9H0J9
TQMLTHRSSDGTYHT	C3P1	171	Q6ZMU1
SHFSLSLRGYSSHMT	INPP5K	291	Q9BT40
SHALMTYSTARISFV	FAT3	3761	Q8TDW7
YASSMVTSSSILDHF	CCDC160	306	A6NGH7
RSYFSHGMISSHITE	DNAAF9	266	Q5TEA3
HSDYSMTLSVRVHTW	MANBA	711	O00462
ESSTKFRHHMYTNVS	DPEP3	231	Q9H4B8
SHHYVSTFLSGVMLT	TMEM120B	191	A0PK00
FHTSNRSHVYAIIMT	GIN1	151	Q9NXP7
HNSHTSATASVMYTV	OR7A17	266	O14581
RVHSHSAVYASSMSP	SPTLC3	391	Q9NUV7
RVTIIHSHSSFSAMA	PIGA	121	P37287
FSYSSAFRRHMITHT	ZNF555	321	Q8NEP9
VFSRMSNLTVHYRSH	RBAK	631	Q9NYW8
TFSCSSSFTVHQRMH	ZNF620	316	Q6ZNG0
TYSTSHAVSVKMHTV	ZNF121	126	P58317
FARSSYLVMHQRTHT	ZNF544	641	Q6NX49
YMSYSSLINHKSTHS	ZFP62	206	Q8NB50
VFSYSSSLMVHQRTH	ZKSCAN7	671	Q9P0L1
AFSRMSYLTVHYRTH	ZNF12	641	P17014
LTVHYMTTSTHYVCE	ZNF423	681	Q2M1K9
FTSNSYLSVHTRMHN	ZNF557	406	Q8N988
SSSLTYHMRTHTGES	ZFP37	501	Q9Y6Q3
YETASLMSQVSHTHL	TYK2	656	P29597