Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentCLOCK-BMAL transcription complex

CLOCK NPAS2

7.27e-055572GO:1990513
DomainCul7

CUL9 HERC2

2.64e-053562PF11515
DomainCPH_domain

CUL9 HERC2

2.64e-053562IPR021097
DomainAPC_su10/DOC_dom

CUL9 HERC2

1.84e-047562IPR004939
DomainDOC

CUL9 HERC2

1.84e-047562PS51284
DomainAPC10

CUL9 HERC2

1.84e-047562SM01337
DomainANAPC10

CUL9 HERC2

1.84e-047562PF03256
DomainNuc_translocat

CLOCK NPAS2

2.44e-048562IPR001067
DomainRib_L2_dom2

CUL9 HERC2

1.31e-0318562IPR014722
Domain-

CUL9 HERC2

1.31e-03185622.30.30.30
DomainPAS_fold_3

CLOCK NPAS2

2.15e-0323562IPR013655
DomainPAS_3

CLOCK NPAS2

2.15e-0323562PF08447
DomainPAS

CLOCK NPAS2

2.53e-0325562PF00989
DomainPAS_fold

CLOCK NPAS2

2.53e-0325562IPR013767
DomainPAC

CLOCK NPAS2

2.74e-0326562IPR001610
DomainPAC

CLOCK NPAS2

2.74e-0326562SM00086
DomainPAC

CLOCK NPAS2

2.74e-0326562PS50113
DomainHECT

HERC2 NEDD4

2.95e-0327562PF00632
DomainHECTc

HERC2 NEDD4

2.95e-0327562SM00119
DomainHECT_dom

HERC2 NEDD4

2.95e-0327562IPR000569
DomainHECT

HERC2 NEDD4

2.95e-0327562PS50237
DomainPAS

CLOCK NPAS2

4.13e-0332562SM00091
DomainPAS

CLOCK NPAS2

4.66e-0334562IPR000014
DomainPAS

CLOCK NPAS2

4.66e-0334562PS50112
DomainBROMODOMAIN_1

BRD4 ASH1L

5.50e-0337562PS00633
DomainBromodomain

BRD4 ASH1L

5.79e-0338562PF00439
DomainBROMODOMAIN_2

BRD4 ASH1L

6.72e-0341562PS50014
Pubmed

Genetic differences between five European populations.

TLR1 EXOC2 HERC2

8.77e-08658320616560
Pubmed

Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice.

FBXW10B FBXW10

2.73e-06258237450367
Pubmed

FBXW10 promotes hepatocarcinogenesis in male patients and mice.

FBXW10B FBXW10

2.73e-06258231400758
Pubmed

Association between restless legs syndrome and CLOCK and NPAS2 gene polymorphisms in schizophrenia.

CLOCK NPAS2

2.73e-06258224824748
Pubmed

NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators.

CLOCK NPAS2

8.19e-06358226895328
Pubmed

Circadian variation of blood pressure and the vascular response to asynchronous stress.

CLOCK NPAS2

8.19e-06358217360665
Pubmed

Peripheral circadian oscillators require CLOCK.

CLOCK NPAS2

8.19e-06358217637349
Pubmed

Association of Per1 and Npas2 with autistic disorder: support for the clock genes/social timing hypothesis.

CLOCK NPAS2

8.19e-06358217264841
Pubmed

Association of CLOCK, ARNTL, and NPAS2 gene polymorphisms and seasonal variations in mood and behavior.

CLOCK NPAS2

8.19e-06358226134245
Pubmed

Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors.

CLOCK NPAS2

8.19e-06358211441146
Pubmed

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration.

CLOCK NPAS2

8.19e-06358224270424
Pubmed

Breast cancer risk, nightwork, and circadian clock gene polymorphisms.

CLOCK NPAS2

8.19e-06358224919398
Pubmed

CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock.

CLOCK NPAS2

8.19e-06358217417633
Pubmed

Control of Toll-like receptor-mediated T cell-independent type 1 antibody responses by the inducible nuclear protein IκB-ζ.

TLR1 CD79A

1.64e-05458225124037
Pubmed

Genetic components of the circadian clock regulate thrombogenesis in vivo.

CLOCK NPAS2

1.64e-05458218413500
Pubmed

Kindlin-3 maintains marginal zone B cells but confines follicular B cell activation and differentiation.

CD79A FERMT3

1.64e-05458234888947
Pubmed

ARNTL (BMAL1) and NPAS2 gene variants contribute to fertility and seasonality.

CLOCK NPAS2

1.64e-05458220368993
Pubmed

Functionally Complete Excision of Conditional Alleles in the Mouse Suprachiasmatic Nucleus by Vgat-ires-Cre.

CLOCK NPAS2

1.64e-05458229671710
Pubmed

Circadian modulation of gene expression, but not glutamate uptake, in mouse and rat cortical astrocytes.

CLOCK NPAS2

1.64e-05458219829696
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

CLPTM1L SLC15A4 ASH1L ASTN2 HERC2 PIGU MTCH1 ADCY2

1.98e-0569758828298427
Pubmed

FBXW10-S6K1 promotes ANXA2 polyubiquitination and KRAS activation to drive hepatocellular carcinoma development in males.

FBXW10B FBXW10

2.72e-05558237277019
Pubmed

Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators.

CLOCK NPAS2

2.72e-05558218316400
Pubmed

Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis.

TRAF3IP2 CD79A

2.72e-05558223123062
Pubmed

CLOCK gene variants associate with sleep duration in two independent populations.

CLOCK NPAS2

2.72e-05558220149345
Pubmed

Model-based prediction of human hair color using DNA variants.

EXOC2 HERC2

2.72e-05558221197618
Pubmed

Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock.

CLOCK NPAS2

2.72e-05558211439184
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

CLPTM1L MTX2 MRPL47 SYNE2 ELP1 PRKCQ CRYBG3 HERC2 PIGU TIMM44 MTCH1

3.18e-051496581132877691
Pubmed

The trophoblast clock controls transport across placenta in mice.

CLOCK NPAS2

5.71e-05758233913482
Pubmed

The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors.

CLOCK NPAS2

5.71e-0575829576906
Pubmed

Transcriptional architecture and chromatin landscape of the core circadian clock in mammals.

CLOCK NPAS2

5.71e-05758222936566
Pubmed

The methamphetamine-sensitive circadian oscillator does not employ canonical clock genes.

CLOCK NPAS2

7.60e-05858219204282
Pubmed

A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.

EXOC2 HERC2

7.60e-05858218483556
Pubmed

Genetic determinants of hair, eye and skin pigmentation in Europeans.

EXOC2 HERC2

1.22e-041058217952075
Pubmed

Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study.

CLOCK NPAS2

1.22e-041058219934327
Pubmed

Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder.

CLOCK NPAS2

1.22e-041058216528748
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

CLPTM1L MTX2 MRPL47 SYNE2 ELP1 CHD1 CRYBG3 HERC2 PIGU TIMM44

1.59e-041487581033957083
Pubmed

Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.

CLOCK NPAS2

1.78e-041258214645221
Pubmed

Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.

MTX2 UBP1 BRD4 EXOC2 HERC2 TIMM44

2.60e-0453358625544563
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

MRPL47 BRD4 ASH1L CHD1 HERC2 CCNC

2.60e-0453358630554943
Pubmed

Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.

EXOC2 HERC2

2.83e-041558223548203
Pubmed

PER2 variantion is associated with depression vulnerability.

CLOCK NPAS2

3.23e-041658219693801
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

UBP1 BRD4 ASH1L EXOC2 RFX2 CLOCK NPAS2

3.82e-0480858720412781
Pubmed

CLOCK is suggested to associate with comorbid alcohol use and depressive disorders.

CLOCK NPAS2

4.11e-041858220180986
Pubmed

NPAS2 and PER2 are linked to risk factors of the metabolic syndrome.

CLOCK NPAS2

4.11e-041858219470168
Pubmed

Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance.

CLOCK NPAS2

4.11e-041858220174623
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SYNE2 SORCS2 MAPK8IP3

4.22e-048758312465718
Pubmed

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.

PRKCQ CERT1 ALPI NEDD4

4.25e-0421058416537572
Pubmed

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.

ELP1 CUL9 CHD1 HERC2

4.40e-0421258433853758
Pubmed

Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.

CLOCK NPAS2

4.59e-041958220072116
Pubmed

Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption.

CLOCK NPAS2

4.59e-041958220554694
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

KNTC1 UBP1 BRD4 SYNE2 TIMM44

5.33e-0439858535016035
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

CUL9 HERC2 NEDD4

5.46e-049558329643511
Pubmed

Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia.

CLOCK NPAS2

5.62e-042158219839995
Pubmed

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.

SYNE2 ELP1 PRKCQ MYRF

6.27e-0423358432290105
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

CLPTM1L UBP1 SYNE2 ELP1 PIGU ADCY2

6.71e-0463858631182584
Pubmed

Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

LMTK2 ADCY2 MAPK8IP3

7.11e-0410458310470851
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

CLPTM1L MTX2 ELP1 HERC2 PIGU MTCH1

7.81e-0465758636180527
Pubmed

Variability in Streptavidin-Sepharose Matrix Quality Can Significantly Affect Proximity-Dependent Biotinylation (BioID) Data.

MTX2 MRPL47 HERC2 PIGU TIMM44

8.20e-0443858532628020
Pubmed

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

HERC2 NEDD4

8.66e-042658226949039
Pubmed

Same but different - Molecular comparison of human KTI12 and PSTK.

ELP1 CRYBG3

9.34e-042758233417976
Pubmed

NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation.

CERT1 NEDD4

9.34e-042758228931009
Pubmed

Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria.

MTX2 MTCH1

1.00e-032858228057766
Pubmed

A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.

CLPTM1L NEDD4

1.23e-033158224292274
Pubmed

Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.

CLPTM1L MTX2 LMBR1 PIGU

1.52e-0329658434186245
GeneFamilyWD repeat domain containing|F-box and WD repeat domain containing

FBXW10B FBXW10

2.59e-0411402559
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B1|367C / Donor, Lineage, Cell class and subclass (all cells)

SLC15A4 SYNE2 LMTK2 LMBR1 PRKCQ

1.99e-06161575f470b662566131dfe69a2fd01186ac8491196396
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DRC7 SYNE2 PRKCQ HERC2 PIGU

1.99e-061615755fba13f0aa5002f7eefe219e2c6a07e163f1a50d
DrugNitrofurantoin [67-20-9]; Up 200; 16.8uM; PC3; HT_HG-U133A

CD1A ASH1L CUL9 RFX2 MYRF ADCY2 MAPK8IP3

5.66e-071995673674_UP
DrugChicago sky blue 6B [2610-05-1]; Down 200; 4uM; PC3; HT_HG-U133A

TRAF3IP2 DNAH3 ASH1L ASTN2 MYRF MAPK8IP3

8.31e-061955666626_DN
DrugGemfibrozil [25812-30-0]; Up 200; 16uM; MCF7; HT_HG-U133A

ASH1L CUL9 ASTN2 PRKCQ OSMR ADCY2

8.56e-061965665488_UP
DrugCTK2H7103

KNTC1 LCTL SLC15A4 BRD4 TLR1 ALPI

1.23e-05209566CID005462309
Diseasecutaneous melanoma, hair color

CLPTM1L SYNE2 HERC2 PIGU

5.16e-0662544EFO_0000389, EFO_0003924
Diseasenevus count, cutaneous melanoma

CLPTM1L SYNE2 HERC2 PIGU

2.38e-0591544EFO_0000389, EFO_0004632
Diseaseinsulin-like growth factor-binding protein 3 measurement

SORCS2 MAPK8IP3

3.28e-055542EFO_0801703
Diseaselevel of Phosphatidylcholine (O-18:2_16:0) in blood serum

SORCS2 MYRF

1.47e-0410542OBA_2045132
DiseaseImmature Reticulocyte Fraction Measurement

OSMR FERMT3

1.47e-0410542EFO_0009253
DiseaseBipolar Disorder

SORCS2 ASTN2 CLOCK ADCY2 NEDD4 NPAS2

2.32e-04477546C0005586
Diseaseintraocular pressure measurement

TRAF3IP2 EXOC2 HERC2 MAPK8IP3 NEDD4 NPAS2

3.28e-04509546EFO_0004695
Diseaselinoleic acid measurement

LIPG CERT1 MYRF MTCH1

3.78e-04186544EFO_0006807
DiseaseSeasonal Affective Disorder

CLOCK NPAS2

3.88e-0416542C0085159
Diseaseage of onset of asthma

TLR1 MYRF NPAS2

4.15e-0479543OBA_2001001
Diseaselevel of Phosphatidylinositol (18:0_18:1) in blood serum

LIPG MYRF

4.94e-0418542OBA_2045155
Diseaseesterified cholesterol measurement, high density lipoprotein cholesterol measurement

LIPG MYRF

5.51e-0419542EFO_0004612, EFO_0008589
Diseaselimited scleroderma

TLR1 EXOC2

5.51e-0419542EFO_1001017
Diseasevery low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio

LIPG SYNE2 CERT1 MYRF

7.35e-04222544EFO_0008317, EFO_0020943
Diseaselevel of Phosphatidylinositol (18:0_20:4) in blood serum

LIPG MYRF

8.11e-0423542OBA_2045158
Diseasecholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement

LIPG SYNE2 CERT1

9.00e-04103543EFO_0008595, EFO_0020944
Diseasesuntan

EXOC2 HERC2 PIGU

9.00e-04103543EFO_0004279
Diseasefree cholesterol measurement

LIPG CERT1 MYRF

1.18e-03113543EFO_0008591
Diseasecerebral infarction (is_implicated_in)

LIPG MYRF

1.29e-0329542DOID:3526 (is_implicated_in)
DiseaseIntellectual Disability

BRD4 ASH1L PIGU CERT1 MAPK8IP3

1.34e-03447545C3714756
Diseasevery low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

LIPG SYNE2 CERT1 MYRF

1.39e-03264544EFO_0008317, EFO_0020944
Diseasenon-melanoma skin carcinoma

CLPTM1L EXOC2 HERC2 PIGU

1.41e-03265544EFO_0009260
Diseasecutaneous melanoma

CLPTM1L SYNE2 HERC2

1.43e-03121543EFO_0000389
Diseasecholesterol:total lipids ratio, intermediate density lipoprotein measurement

LIPG SYNE2 CERT1

1.43e-03121543EFO_0008595, EFO_0020943
Diseasemelanoma

CLPTM1L EXOC2 PIGU

1.61e-03126543EFO_0000756
Diseaseprostate cancer (implicated_via_orthology)

MEP1A CHD1

1.67e-0333542DOID:10283 (implicated_via_orthology)
Diseasesphingomyelin measurement

LIPG SYNE2 CERT1 MYRF

1.68e-03278544EFO_0010118
Diseasephosphatidylcholine measurement

LIPG SYNE2 PRKCQ MYRF

1.82e-03284544EFO_0010226

Protein segments in the cluster

PeptideGeneStartEntry
QLPYDILWQWKHNQL

ASH1L

2051

Q9NR48
LHFYTQSVWVKSGLW

CRYBG3

2781

Q68DQ2
LKTLWKHQFAWPFQQ

BRD4

71

O60885
ILYWFANSTQWTKAN

FBXW10

121

Q5XX13
NANVTWWRVLHGNYT

CD79A

61

P11912
IQYLIKWKGWSHIHN

CHD1

316

O14646
WRQQWLENGTLYFHV

ASTN2

161

O75129
WVGNYSTTVKWNQVL

OSMR

81

Q99650
FLTKGQQWIWLQTHY

NPAS2

316

Q99743
WQSSHYLQWILDKQD

CCNC

6

P24863
ILYWFANSTQWTKAN

FBXW10B

121

O95170
YIHGWQDRWVVLKNN

CERT1

36

Q9Y5P4
LLGQKYNHSVDWWSF

PRKCQ

551

Q04759
QNGWLYVHSAVANWK

MAPK8IP3

976

Q9UPT6
GYSANHQVIQWFWKA

NEDD4

1216

P46934
WQQKGGTYWVRYIHV

HERC2

2611

O95714
YIQWLNGSLIHGLWN

LMBR1

96

Q8WVP7
WIASFYNHSWKQNLV

CD1A

31

P06126
YNHSWKQNLVSGWLS

CD1A

36

P06126
SQLPNFWKLWISYVN

EXOC2

461

Q96KP1
WHSYNTTWRSKQQGL

LCTL

241

Q6UWM7
KIQLTWEGASQSWYN

LIPG

411

Q9Y5X9
HSLWQVPYFSKAWQR

KNTC1

2006

P50748
QTKYSNIWSLGVTLW

LMTK2

326

Q8IWU2
QLWTVGNYHWYLKQS

ELP1

321

O95163
SYSVFWQQNQKGSIW

OVOS2

1011

Q6IE36
VLWHLWIYAGSANSN

PIGU

371

Q9H490
NLVQEWLAKHQGAWY

ALPI

251

P09923
QAAFLHLWWTVYQNN

GYG2

276

O15488
HLWWTVYQNNVLPLY

GYG2

281

O15488
SQYLQFKTWWIDGVQ

ERVK-5

361

Q9HDB9
IGLQKWQYDVWSHDV

ADCY2

396

Q08462
IKQASGHWETWTQYI

DNAH3

2016

Q8TD57
TTNDQQGYVVHKWSW

C3orf20

451

Q8ND61
QNIYWEHLSIRGFIW

TMEM63B

416

Q5T3F8
LGIESLWNHKNYWIN

DRC7

336

Q8IY82
VQVFWQSTGRTYWVH

CUL9

416

Q8IWT3
YLLSKQGKSWHYQLW

C19orf54

286

Q5BKX5
SKNYTYIWWLNGQSL

PSG4

266

Q00888
NWFYWSINLGAILSL

SLC15A4

196

Q8N697
WPLNHILAYQKQWEV

MTX2

151

O75431
WIHCWKYLSVQGQLF

MTCH1

356

Q9NZJ7
LTKWLESSQHTLNYW

SYNE2

4956

Q8WXH0
NLQFHYIEKLWLSFW

RFX2

386

P48378
FQWQWLYQLLVEGST

GPR108

471

Q9NPR9
VNIWWDQILSGYQHN

MEP1A

176

Q16819
PNLTVFYWWIGHSLQ

SORCS2

901

Q96PQ0
FKQWVIPWHLNKRYN

MRPL47

181

Q9HD33
QLVWHTTVWYFSISN

TLR1

266

Q15399
FLTKGQQWIWLQTHY

CLOCK

341

O15516
KSWYSWLINSFVNGV

CLPTM1L

426

Q96KA5
TWLQNTHVYSWPKNK

TRAF3IP2

531

O43734
LYTSWLKPVNAFNVW

TUBD1

366

Q9UJT1
NWKRKIIAVYSGHQW

PRSS35

361

Q8N3Z0
QWLLQTHWTLDKYGI

FERMT3

71

Q86UX7
ASIQGFSSKIIHWYW

TRGV11

41

A0A075B6L2
LQYTEHQQLEGWKWN

UBP1

126

Q9NZI7
LGVVLHKDSKWYQQW

TIMM44

231

O43615
YETLKNWWLQQYSHD

SLC25A23

356

Q9BV35
GHKWALKALWNYLSQ

TTLL4

831

Q14679
IKWQPHQQNKWATLY

MYRF

351

Q9Y2G1