Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnuclear estrogen receptor binding

NCOA2 NCOA6 LATS1 FOXL2

1.81e-0553594GO:0030331
DomainUBA-like

LATS1 UBQLN1 TNRC6B UBALD1

4.95e-0564594IPR009060
DomainDUF4599

SPATA31E1 SPATA31C2

6.34e-0412592PF15371
DomainDUF4599

SPATA31E1 SPATA31C2

6.34e-0412592IPR027970
Domain-

PTPN14 RASAL3 SPTBN2 DAB1 OSBPL6 GAB2

1.43e-033915962.30.29.30
DomainC2_dom

RASAL3 HECW2 OSBPL6 RIMS2

1.79e-03164594IPR000008
DomainPH_dom-like

PTPN14 RASAL3 SPTBN2 DAB1 OSBPL6 GAB2

2.21e-03426596IPR011993
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

SCYL2 NCOA2 NCOA6 PTPN14 LATS1 REPS1 WIZ SPTBN2 ARFGAP1 TNRC6B SCRIB

4.80e-09549641138280479
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

SRRM1 ISLR2 ZSWIM8 PTPN14 WIZ RASAL3 MYO1C POGK CECR2 ZNF629 TNRC6B SCRIB NUFIP1

1.03e-071116641331753913
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

SRRM1 NCOA6 PTPN14 LATS1 ARFGAP1 ZNF629 OSBPL6 SCRIB TESK1 ABTB2 GAB2

4.52e-07861641136931259
Pubmed

LATS1 phosphorylates forkhead L2 and regulates its transcriptional activity.

LATS1 FOXL2

3.33e-06264220407010
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

PTPN14 MAGED1 ARFGAP1 TNRC6B LRRC7 SCRIB

9.17e-0626364634702444
Pubmed

HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading PTPN14.

PTPN14 LATS1

9.99e-06364239248565
Pubmed

PTPN14 acts as a candidate tumor suppressor in prostate cancer and inhibits cell proliferation and invasion through modulating LATS1/YAP signaling.

PTPN14 LATS1

9.99e-06364232645410
Pubmed

PTPN14 forms a complex with Kibra and LATS1 proteins and negatively regulates the YAP oncogenic function.

PTPN14 LATS1

9.99e-06364225023289
Pubmed

Two classes of ovarian primordial follicles exhibit distinct developmental dynamics and physiological functions.

FOXL2 SOHLH1

9.99e-06364224087793
Pubmed

Life-long in vivo cell-lineage tracing shows that no oogenesis originates from putative germline stem cells in adult mice.

FOXL2 SOHLH1

9.99e-06364225453063
Pubmed

Alternative Splicing of Disabled-1 Controls Multipolar-to-Bipolar Transition of Migrating Neurons in the Neocortex.

DAB1 TBR1

9.99e-06364228968791
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

NCOA6 LATS1 UBQLN1 MAGED1 RASAL3 SPATA31E1 ZHX1

1.42e-0543064735044719
Pubmed

Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway.

PTPN14 LATS1 MYO1C

1.50e-052664328720576
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SCYL2 NCOA2 ZSWIM8 UBQLN1 MAGED1 REPS1 WIZ SPTBN2 DENND6B SCRIB NUFIP1

2.07e-051285641135914814
Pubmed

The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy.

PTPN14 LATS1

3.32e-05564232292505
Pubmed

A widely expressed betaIII spectrin associated with Golgi and cytoplasmic vesicles.

ZP1 SPTBN2

4.98e-0566429826670
Pubmed

The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells.

LATS1 SCRIB

4.98e-05664222078877
Pubmed

Human transcription factor protein interaction networks.

NCOA2 NCOA6 MAGED1 WIZ MYO1C ARFGAP1 ZNF629 TNRC6B TBR1 SSBP3 ZHX1

5.44e-051429641135140242
Pubmed

Dual functions of Dab1 during brain development.

DAB1 TBR1

6.96e-05764218981215
Pubmed

High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper layer cortical plate neurons.

DAB1 TBR1

6.96e-05764215249135
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

SRRM1 WIZ MYO1C ARFGAP1 ACBD5 TNRC6B SCRIB GAB2

8.79e-0577764835844135
Pubmed

Oocytes in newborn MRL mouse testes.

ZP1 FOXL2

9.27e-05864218354036
Pubmed

Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin.

DAB1 TBR1

9.27e-05864228213441
Pubmed

Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.

LATS1 SCRIB

1.19e-04964228169360
Pubmed

A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum.

DAB1 TBR1

1.19e-04964231491533
Pubmed

Expression and possible roles of extracellular signal-related kinases 1-2 (ERK1-2) in mouse primordial germ cell development.

FOXL2 SOHLH1

1.19e-04964232418930
Pubmed

Global proteomics of Ubqln2-based murine models of ALS.

SCYL2 LATS1 UBQLN1 MAGED1 ACBD5

1.22e-0426164533277362
Pubmed

AMPK modulates Hippo pathway activity to regulate energy homeostasis.

PTPN14 LATS1

1.49e-041064225751139
Pubmed

Physiological significance of proteolytic processing of Reelin revealed by cleavage-resistant Reelin knock-in mice.

DAB1 TBR1

1.49e-041064232161359
Pubmed

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

TMEM245 TACR3 SCRIB GAB2

1.68e-0414964425231870
Pubmed

The Hippocampal Response to Acute Corticosterone Elevation Is Altered in a Mouse Model for Angelman Syndrome.

NCOA2 NCOA6

1.81e-041164236613751
Pubmed

Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity.

PTPN14 LATS1

1.81e-041164225283809
Pubmed

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

NCOA2 MAGED1 TNRC6B SSBP3

1.82e-0415264438360978
Pubmed

Role of heat-shock factor 2 in cerebral cortex formation and as a regulator of p35 expression.

DAB1 TBR1

2.17e-041264216600913
Pubmed

Absence of Fyn and Src causes a reeler-like phenotype.

DAB1 TBR1

2.57e-041364216162939
Pubmed

Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration.

DAB1 TBR1

2.99e-041464221460838
Pubmed

Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.

NCOA2 NCOA6

2.99e-041464212482968
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

SCYL2 LATS1 REPS1 ARFGAP1 TNRC6B LRRC7 SCRIB

3.20e-0470864739231216
Pubmed

IGF-I promotes neuronal migration and positioning in the olfactory bulb and the exit of neuroblasts from the subventricular zone.

DAB1 TBR1

3.45e-041564219712103
Pubmed

GABRA1 and STXBP1: novel genetic causes of Dravet syndrome.

RIMS2 ABTB2

3.45e-041564224623842
Pubmed

Impaired Reelin-Dab1 Signaling Contributes to Neuronal Migration Deficits of Tuberous Sclerosis Complex.

DAB1 TBR1

3.93e-041664226235615
Pubmed

Local network topology in human protein interaction data predicts functional association.

NCOA2 GAB2

3.93e-041664219641626
Pubmed

Genetic ablation of the Rho GTPase Rnd3 triggers developmental defects in internal capsule and the globus pallidus formation.

ISLR2 TBR1

3.93e-041664233576044
Pubmed

A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex.

DAB1 TBR1

4.45e-041764217694053
Pubmed

Reelin regulates cadherin function via Dab1/Rap1 to control neuronal migration and lamination in the neocortex.

DAB1 TBR1

4.45e-041764221315259
Pubmed

Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.

NCOA2 NCOA6 WIZ

4.92e-048364328794006
Pubmed

Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo.

DAB1 TBR1

5.00e-041864218599437
Pubmed

Lis1-Nde1-dependent neuronal fate control determines cerebral cortical size and lamination.

DAB1 TBR1

5.00e-041864218469343
Pubmed

Common partner Smad-independent canonical bone morphogenetic protein signaling in the specification process of the anterior rhombic lip during cerebellum development.

DAB1 TBR1

5.00e-041864223459943
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

SRRM1 NCOA6 LATS1 MYO1C ARFGAP1 SCRIB ZHX1

5.44e-0477464715302935
Pubmed

αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development.

LATS1 SCRIB

5.59e-041964227405641
Pubmed

Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells.

TACR3 PRLR

5.59e-041964225855264
Pubmed

Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap.

LATS1 SCRIB

5.59e-041964226235047
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

NCOA2 SRRM1 MYO1C SCRIB

5.96e-0420864433230847
Pubmed

T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities.

NCOA2 NCOA6

6.20e-042064211877444
Pubmed

Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons.

DAB1 TBR1

6.20e-042064212130536
Pubmed

Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function.

DAB1 TACR3

6.84e-042164221835343
Pubmed

Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor.

NCOA2 NCOA6

6.84e-042164219596656
Pubmed

Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm.

LATS1 TNRC6B

7.52e-042264222187428
Pubmed

Simultaneous gene deletion of gata4 and gata6 leads to early disruption of follicular development and germ cell loss in the murine ovary.

FOXL2 SOHLH1

7.52e-042264224899573
Pubmed

Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner.

SRRM1 LATS1 MYO1C PTPRQ

7.61e-0422264435941108
Pubmed

Tbr1 regulates differentiation of the preplate and layer 6.

DAB1 TBR1

8.23e-042364211239428
Pubmed

Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP.

PTPN14 LATS1

8.23e-042364226933062
Pubmed

The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number.

LATS1 TBR1

8.96e-042464230523785
Pubmed

Ablation of vacuole protein sorting 18 (Vps18) gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes.

DAB1 TBR1

8.96e-042464222854957
Pubmed

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

ISLR2 POGK CNTN3

9.22e-0410364310819331
Pubmed

Presenilin 1 in migration and morphogenesis in the central nervous system.

DAB1 TBR1

9.73e-042564215163631
Pubmed

Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8.

ZP1 SOHLH1

9.73e-042564216690745
Pubmed

Gse1, a component of the CoREST complex, is required for placenta development in the mouse.

ISLR2 SCRIB

9.73e-042564237019373
Pubmed

Aberrant differentiation of second heart field mesoderm prefigures cellular defects in the outflow tract in response to loss of FGF8.

ISLR2 SCRIB

1.05e-032664237060937
Pubmed

Discovery of novel protein partners of the transcription factor FOXL2 provides insights into its physiopathological roles.

ZSWIM8 FOXL2

1.14e-032764222544055
Pubmed

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.

SRRM1 REPS1 MYO1C OSBPL6 LRRC7

1.18e-0343064532581705
Pubmed

The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone.

DAB1 TBR1

1.22e-032864218794345
Pubmed

Sohlh2 affects differentiation of KIT positive oocytes and spermatogonia.

ZP1 SOHLH1

1.22e-032864219014927
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

CYP1B1 SRRM1 MAGED1 REPS1 MYO1C SPTBN2 ARFGAP1 SCRIB SSBP3

1.23e-03144064930833792
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

NCOA2 MAGED1 REPS1 ARFGAP1 TNRC6B

1.36e-0344464534795231
Pubmed

High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.

OSBPL6 TBR1

1.40e-033064219401682
Pubmed

Lats1/2 inactivation reveals Hippo function in alveolar type I cell differentiation during lung transition to air breathing.

LATS1 SCRIB

1.50e-033164230305289
Pubmed

Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate.

LATS1 FOXL2

1.50e-033164236362374
Pubmed

TBX1 is required for normal stria vascularis and semicircular canal development.

UBQLN1 ABTB2

1.50e-033164231550482
Pubmed

Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.

SRRM1 PTPN14 LATS1 SCRIB

1.57e-0327064424366813
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

CYP1B1 UBQLN1 MAGED1 REPS1 WIZ ACBD5 TNRC6B SSBP3 ZHX1

1.61e-03149764931527615
Pubmed

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.

MYO1C SPTBN2 ZNF629 SCRIB

1.65e-0327464434244482
Pubmed

Wnt signalling regulates paxillin ubiquitination essential for mesodermal cell motility.

UBQLN1 MAGED1

1.70e-033364217558393
Pubmed

Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.

ARFGAP1 DAB1 RIMS2

1.72e-0312864330995482
Pubmed

Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.

DAB1 ZNF629

1.80e-033464223449627
InteractionWWTR1 interactions

SCYL2 NCOA2 NCOA6 PTPN14 LATS1 WIZ ARFGAP1 TNRC6B SCRIB

4.08e-06422609int:WWTR1
InteractionTBXT interactions

NCOA2 NCOA6 WIZ TBR1 SSBP3

2.46e-05116605int:TBXT
InteractionLATS1 interactions

SRRM1 PTPN14 LATS1 FOXL2 MYO1C PTPRQ TNRC6B TBR1

4.59e-05440608int:LATS1
InteractionJPH4 interactions

ZSWIM8 PTPN14 UBQLN1 OSBPL6

5.01e-0568604int:JPH4
InteractionWWC2 interactions

PTPN14 LATS1 REPS1

7.79e-0528603int:WWC2
InteractionYWHAH interactions

NCOA2 SRRM1 NCOA6 PTPN14 LATS1 ARFGAP1 ZNF629 OSBPL6 SCRIB RIMS2 TESK1 GAB2

8.22e-0511026012int:YWHAH
InteractionSAV1 interactions

PTPN14 LATS1 TNRC6B KIF3C ABTB2

8.66e-05151605int:SAV1
Cytoband9q22.1

SPATA31E1 SPATA31C2

3.22e-04196429q22.1
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PTPRQ CNTN3 LRRC7 TACR3 RIMS2 PRLR

1.25e-07162646bf886e22ff2a20353499004b53f25fb9e6574896
Diseasebenign neoplasm (implicated_via_orthology)

LATS1 SCRIB

1.21e-048622DOID:0060072 (implicated_via_orthology)
Diseasekidney cancer (implicated_via_orthology)

LATS1 SCRIB

2.36e-0411622DOID:263 (implicated_via_orthology)
DiseaseIschemic stroke, coronary artery disease

CYP1B1 WIZ RASAL3

9.71e-0492623EFO_0001645, HP_0002140
Diseaseprogranulin measurement

NCOA2 UBQLN1

9.77e-0422622EFO_0004625
DiseasePigmented Basal Cell Carcinoma

PTPN14 LATS1

1.59e-0328622C1368275
DiseaseCarcinoma, Basal Cell

PTPN14 LATS1

1.70e-0329622C4721806

Protein segments in the cluster

PeptideGeneStartEntry
PPPTQAWLQTVSSDP

PABPN1L

11

A6NDY0
QTAPQPTSQRPSWWP

ACBD5

486

Q5T8D3
LESSPAQNWTPPQPR

ARFGAP1

126

Q8N6T3
TPWKTPPQIQPFSQD

DENND6B

446

Q8NEG7
PPVPPNQWTEQSGFL

CECR2

836

Q9BXF3
QTQAQTPTPAPAWPA

ISLR2

311

Q6UXK2
QLSPRTRGSWSQPQP

RASAL3

986

Q86YV0
RTTTWQRPTAPPAPQ

HECW2

831

Q9P2P5
QSPPARQTPPAWQNP

MAGED1

321

Q9Y5V3
IPTWQPNIPVRSNSF

LATS1

451

O95835
VPPSNPWQNWTRTPS

LRRC7

836

Q96NW7
LNGQPQWSALFTLPP

KCNQ1DN

51

Q9H478
RANSTPNPPWSFQRS

FAM124A

346

Q86V42
RSWCQSPQRPPPSTT

KIF3C

761

O14782
WPGTTQPPSPQLLRN

FAM157A

266

C9JC47
SGSPPRQPPQFWDSQ

PEAR1

951

Q5VY43
QSGFLNNSWPLPQPP

FOXL2

196

P58012
QPWSSAPFKPTAQLP

KLKP1

96

Q107X0
QPSAPTWNGNFFPPQ

KCNRG

146

Q8N5I3
WPNPMNATSQFPQPQ

POGK

131

Q9P215
QTTPSPQGRQSPWPL

POM121L12

41

Q8N7R1
QPNSFPWQSPLPCSN

OSBPL6

221

Q9BZF3
PWQSPLPCSNSLPAT

OSBPL6

226

Q9BZF3
NSPPANPSIFSWDPL

MOCS1

391

Q9NZB8
LSWNTPPNPNGRIIS

PTPRQ

116

Q9UMZ3
TRSWSPSVPPPQSRN

RIMS2

1026

Q9UQ26
FTAPTQVPVPPGWNQ

NCOA6

306

Q14686
QPGLFPATQQPWPTV

DAB1

376

O75553
PATQQPWPTVAGQFP

DAB1

381

O75553
SPNDPWPLNPLSIQQ

CYP1B1

6

Q16678
TPPSQPPGNVVWNAT

CNTN3

901

Q9P232
WGSPQQRPPISENSR

GAB2

366

Q9UQC2
KAVRPPLSWPPFSQQ

SOHLH1

236

Q5JUK2
PLSWPPFSQQQTLPV

SOHLH1

241

Q5JUK2
PWPNPNSANSIPYSS

SSBP3

246

Q9BWW4
SPQQSPPTSPHTWRK

REPS1

166

Q96D71
PGAPSPQRWFVTPAN

TBR1

476

Q16650
PESQPFISSTPQFWP

SPATA31C2

331

B4DYI2
QSNSPPPIRRQPTWS

PTPN14

311

Q15678
PNQWLNQFVPPQGSP

SCYL2

861

Q6P3W7
QAPPFPQSTFTPWAS

SPATA31E1

866

Q6ZUB1
LSPRPASPKAQWPQS

WIZ

1011

O95785
EQPPWASPSPTSRQS

SCRIB

1431

Q14160
PVASPAPSQPWANLT

TACR3

61

P29371
PARQARQPPQPITWS

ABTB2

366

Q8N961
TSFRSSPWQQPPPLQ

CHSY3

96

Q70JA7
EPPSTSQAWNPPRAN

CLCN2

416

P51788
QQAPPNQTAPWPESI

NCOA2

1026

Q15596
QGQWPPLTSRALQTP

TXN2

21

Q99757
TSPGVPWPSQSANFP

UHRF1BP1L

1401

A0JNW5
QALQESSPQGPSPWP

ZSCAN10

161

Q96SZ4
PSANPFQQPQWPILS

ZP1

461

P60852
QSPLDSQPQPSGQPW

NUFIP1

96

Q9UHK0
TTWDGTQPRPPPSTQ

SPTBN2

2121

O15020
APPSPVQSQSPSTNW

SRRM1

766

Q8IYB3
NRDPLPNPWAPQTSQ

UBQLN1

316

Q9UMX0
WPLPQPSQHNPRSSY

PRLR

416

P16471
QPKQSWNPFPDFTPQ

ZHX1

556

Q9UKY1
WSPRSGPVLNNNPPA

TESK1

506

Q15569
PGSRPPSRNWNSETP

ZSWIM8

936

A7E2V4
SPTNSVPTPNQTPWP

TMEM245

846

Q9H330
RSPPQSAVPTPWVTF

PRR29

11

P0C7W0
TWNSPPVVPANEPSL

ZNF629

121

Q9UEG4
PPPGNVRPSNSSWSS

TNRC6B

846

Q9UPQ9
PASDWPPLAPQQATS

UBALD1

151

Q8TB05
WFRIPNQFQSDPPAP

HEBP1

101

Q9NRV9
QNVLDTSWPTPPPAL

MYO1C

826

O00159
NLSNRPSFNRTPIPW

MYOZ1

261

Q9NP98