Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessregulation of complement activation

C3 CD46 SVEP1

1.77e-0527393GO:0030449
GeneOntologyBiologicalProcesscomplement activation, classical pathway

C3 CD46 SVEP1

7.84e-0544393GO:0006958
GeneOntologyBiologicalProcessnegative regulation of complement activation, classical pathway

CD46 SVEP1

9.68e-058392GO:0045959
GeneOntologyBiologicalProcessregulation of complement activation, classical pathway

CD46 SVEP1

1.55e-0410392GO:0030450
GeneOntologyBiologicalProcessregulation of humoral immune response

C3 CD46 SVEP1

1.99e-0460393GO:0002920
GeneOntologyBiologicalProcesshumoral immune response mediated by circulating immunoglobulin

C3 CD46 SVEP1

2.19e-0462393GO:0002455
GeneOntologyBiologicalProcessnegative regulation of humoral immune response mediated by circulating immunoglobulin

CD46 SVEP1

2.27e-0412392GO:0002924
GeneOntologyBiologicalProcessnegative regulation of complement activation

CD46 SVEP1

3.12e-0414392GO:0045916
GeneOntologyBiologicalProcesscomplement activation

C3 CD46 SVEP1

3.13e-0470393GO:0006956
GeneOntologyBiologicalProcessnegative regulation of immunoglobulin mediated immune response

CD46 SVEP1

4.11e-0416392GO:0002890
GeneOntologyBiologicalProcessnegative regulation of B cell mediated immunity

CD46 SVEP1

4.11e-0416392GO:0002713
GeneOntologyBiologicalProcessregulation of immunoglobulin mediated immune response

C3 CD46 SVEP1

4.47e-0479393GO:0002889
GeneOntologyBiologicalProcessregulation of B cell mediated immunity

C3 CD46 SVEP1

4.47e-0479393GO:0002712
MousePhenoiris stroma hypoplasia

LGR4 FOXC2

2.85e-054312MP:0006230
MousePhenodecreased renal glomerulus number

LGR4 C1GALT1 FOXC2

3.85e-0530313MP:0004505
MousePhenoabsent palatine bone

BNC2 FOXC2

4.74e-055312MP:0004476
MousePhenoabnormal kidney physiology

LGR4 C3 C1GALT1 GALNT3 CYP19A1 FOXC2

1.43e-04372316MP:0002136
MousePhenoabnormal canal of Schlemm morphology

LGR4 FOXC2

1.70e-049312MP:0005204
MousePhenoabnormal iris stroma morphology

LGR4 FOXC2

2.12e-0410312MP:0005208
MousePhenoabnormal trabecular meshwork morphology

LGR4 FOXC2

2.12e-0410312MP:0005203
MousePhenolymphedema

SVEP1 FOXC2

2.59e-0411312MP:0003390
MousePhenoiris hypoplasia

LGR4 FOXC2

2.59e-0411312MP:0006226
MousePhenoabnormal renal glomerulus morphology

LGR4 C3 C1GALT1 CYP19A1 FOXC2

2.63e-04264315MP:0005325
MousePhenoabnormal nephron morphology

LGR4 C3 C1GALT1 NEK9 CYP19A1 FOXC2

2.98e-04426316MP:0003881
MousePhenodilated capillary

C1GALT1 FOXC2

3.66e-0413312MP:0020326
MousePhenoincreased inflammatory response

USP25 LGR4 LANCL1 TARM1 C3 C1GALT1 LPAR2 COX4I2 CYP19A1

3.95e-041077319MP:0001846
MousePhenoabnormal renal corpuscle morphology

LGR4 C3 C1GALT1 CYP19A1 FOXC2

4.25e-04293315MP:0002827
MousePhenoabnormal lymphatic vessel morphology

SEMA3F SVEP1 FOXC2

4.69e-0469313MP:0001879
MousePhenoabnormal circulating iron level

SEMA3F TAMM41 NEK9 CYP19A1

5.14e-04170314MP:0004152
MousePhenolarge fontanelles

BNC2 CTSK

5.60e-0416312MP:0030388
MousePhenoabnormal male reproductive gland physiology

LGR4 GALNT3 CYP19A1

6.22e-0476313MP:0013327
MousePhenodecreased fetal weight

ELOVL4 LGR4 C3

6.46e-0477313MP:0009431
MousePhenoabnormal kidney cortex morphology

LGR4 C3 C1GALT1 CYP19A1 FOXC2

6.71e-04324315MP:0000521
MousePhenoabnormal renal/urinary system physiology

LGR4 C3 C1GALT1 ACAD8 GALNT3 CYP19A1 FOXC2

6.72e-04695317MP:0005502
MousePhenospinal hemorrhage

C1GALT1 FOXC2

7.12e-0418312MP:0006054
DomainTBC

GRTP1 USP6NL

4.46e-0349382SM00164
DomainSushi

CD46 SVEP1

5.01e-0352382PF00084
DomainRabGAP-TBC

GRTP1 USP6NL

5.20e-0353382PF00566
DomainCCP

CD46 SVEP1

5.40e-0354382SM00032
DomainKelch-typ_b-propeller

FBXO42 KLHL23

5.59e-0355382IPR015915
DomainTBC_RABGAP

GRTP1 USP6NL

5.59e-0355382PS50086
DomainRab-GTPase-TBC_dom

GRTP1 USP6NL

5.59e-0355382IPR000195
DomainSUSHI

CD46 SVEP1

5.79e-0356382PS50923
DomainSushi_SCR_CCP_dom

CD46 SVEP1

6.00e-0357382IPR000436
DomainGal_Oxase/kelch_b-propeller

FBXO42 KLHL23

6.41e-0359382IPR011043
Pubmed

The paramyxoviruses simian virus 5 and mumps virus recruit host cell CD46 to evade complement-mediated neutralization.

C3 CD46

1.23e-06239219457998
Pubmed

The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome.

C3 CD46

1.23e-06239225879158
Pubmed

Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome.

C3 CD46

1.23e-06239218796626
Pubmed

Contribution of the repeating domains of membrane cofactor protein (CD46) of the complement system to ligand binding and cofactor activity.

C3 CD46

3.67e-0633921717583
Pubmed

The Complement Regulatory Protein CD46 Deficient Mouse Spontaneously Develops Dry-Type Age-Related Macular Degeneration-Like Phenotype.

C3 CD46

7.34e-06439227295359
Pubmed

New functional and structural insights from updated mutational databases for complement factor H, Factor I, membrane cofactor protein and C3.

C3 CD46

7.34e-06439225188723
Pubmed

The CD46-Jagged1 interaction is critical for human TH1 immunity.

C3 CD46

1.83e-05639223086448
Pubmed

Atypical postinfectious glomerulonephritis is associated with abnormalities in the alternative pathway of complement.

C3 CD46

1.83e-05639223235567
Pubmed

Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome.

C3 CD46

2.56e-05739220513133
Pubmed

Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome.

C3 CD46

2.56e-05739219861685
Pubmed

C3 Glomerulopathy

C3 CD46

3.42e-05839220301598
Pubmed

Negligible role of antibodies and C5 in pregnancy loss associated exclusively with C3-dependent mechanisms through complement alternative pathway.

C3 CD46

3.42e-05839214670299
Pubmed

Genetic Atypical Hemolytic-Uremic Syndrome

C3 CD46

6.70e-051139220301541
Pubmed

Detection of novel skeletogenesis target genes by comprehensive analysis of a Runx2(-/-) mouse model.

PRKG2 CTSK NPNT

7.07e-057139316829211
Pubmed

Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling.

SVEP1 FOXC2

1.46e-041639228179430
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

SEMA3F C3 SVEP1 NPNT

1.71e-0424839424006456
Pubmed

Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.

LGR4 GALNT3

3.05e-042339224945404
Pubmed

Hemodynamic force is required for vascular smooth muscle cell recruitment to blood vessels during mouse embryonic development.

SEMA3F FOXC2

3.33e-042439230796970
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

SEMA3F LGR4 LANCL1 C1GALT1 CD46 GALNT3 NEK9

3.36e-04120139735696571
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

IPO5 LGR4 LANCL1 C3 NDUFS7 PFKP TAMM41

5.33e-04129739733545068
Pubmed

Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.

C3 CD46

5.58e-043139219344414
Pubmed

Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2.

LGR4 FOXC2

6.33e-043339218424556
Pubmed

Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts.

LPAR2 PLA2G2E

6.33e-043339239002541
Pubmed

Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.

IPO5 C1GALT1

8.84e-043939224556642
Pubmed

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

IPO5 SEMA3F C1GALT1 NDUFS7 PFKP PLA2G2E USP6NL

1.03e-03145139730550785
Pubmed

Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.

GRTP1 USP6NL

1.07e-034339219077034
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

PFKP RBM47 USP6NL

1.09e-0318039335198878
GeneFamilyComplement system|Sushi domain containing

C3 CD46

1.41e-0336282492
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

CD46 SVEP1

3.50e-03572821179
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DRC7 BNC2 CD46 PRKG2 FOXC2

4.35e-0717539559249c9e83952d7277010e7be3c779e26399eb5d
ToppCellfacs-Skin-Anagen-24m-Epithelial-outer_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R3C DRC7 LGR4 YIPF7 NPNT

4.35e-071753955552ff1e13f931c8cd7780726c90b5609497a648
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DRC7 BNC2 CD46 PRKG2 FOXC2

4.35e-07175395b35cc1357495f2a03a6500f807c6e6f8c877734d
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Mesenchymal-ependymal_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DRC7 C3 ACAD8 PFKP RBM47

5.00e-071803959ef79a7c60227e352ac166c7274adb31f585f5ca
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Mesenchymal-Ependyma|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DRC7 C3 ACAD8 PFKP RBM47

5.00e-07180395729f0d7af573c7796d8e28e6eec3af2fc0bd33a2
ToppCell3'-Child04-06-SmallIntestine-Mesenchymal-stromal_related-T_reticular|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PPP1R3C BNC2 C3 CTSK SVEP1

8.00e-071983955c96778cf5623c662c2259fe70f8665c14a161dd
ToppCellmedial-mesenchymal-Airway_Smooth_Muscle|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PPP1R3C COX4I2 NPNT KLHL23 FOXC2

8.41e-07200395c1d9748aaae489d26e24602a5dcbe7f5fa9a5548
ToppCellmedial-mesenchymal-Airway_Smooth_Muscle-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PPP1R3C COX4I2 NPNT KLHL23 FOXC2

8.41e-072003956a5047018b12be3bc4b55a64d42e52e96c624003
ToppCellmedial-2-mesenchymal-Airway_Smooth_Muscle|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PPP1R3C COX4I2 NPNT KLHL23 FOXC2

8.41e-0720039516b00eacbea4d75cf814803d3fc0b82c2b8c0a9c
ToppCellfacs-Kidney-nan-24m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C3 PLA2G2E CTSK SVEP1

1.83e-05180394f9f8245cbcdea18c15e2976c85b72c6807309787
ToppCelldroplet-Kidney-nan-18m-Epithelial-Stroma____kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R3C PRKG2 COX4I2 FOXC2

1.83e-05180394b6f44fdedc33b7d93b0074e8e9c8cc32009d4c4d
ToppCelltumor_Lung-Fibroblasts-Undetermined|tumor_Lung / Location, Cell class and cell subclass

C3 CTSK SVEP1 NPNT

1.87e-0518139453bcab4d6df4a3255d81877ba22fb95d4492ce9f
ToppCellP28-Mesenchymal-mesenchymal_fibroblast|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

C3 PRKG2 SVEP1 NPNT

1.87e-05181394091e7975badd1ffa463a8ec87908be20781ecfd6
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast|E18.5-samps / Age Group, Lineage, Cell class and subclass

PPP1R3C PRKG2 SVEP1 NPNT

1.91e-05182394ceb37c214662a48efb56ab0d015977c6fab478b0
ToppCellfacs-Lung-Endomucin-24m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD46 COX4I2 USP6NL KLHL23

1.91e-05182394be9c312a44868d4ee266a64d066feb8c5bce5687
ToppCellControl-Epithelial_alveolar-AT_2-AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

C3 GALNT3 GRTP1 RBM47

1.91e-05182394e97681a4102f3095d5d9e90ad70f1dc46e90983a
ToppCellPericytes-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

PPP1R3C COX4I2 KLHL23 FOXC2

1.91e-0518239446c213597445b1f4f09dc367f27702d24b201daf
ToppCellfacs-Lung-Endomucin-24m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD46 COX4I2 USP6NL KLHL23

1.91e-0518239474dbb706bcaa0f8c922bf3b0424bce5bb27167fa
ToppCellPericytes-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

PPP1R3C COX4I2 KLHL23 FOXC2

1.95e-051833944617b18da8d699a44e4c47980197b1e7eb951470
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Stroma____kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R3C PRKG2 COX4I2 FOXC2

1.95e-051833948de4b616a06be03e1cb6ae6a9ce6bf06485629d3
ToppCellPericytes-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

PPP1R3C COX4I2 KLHL23 FOXC2

1.99e-05184394cd10d351d91a81dd6dc806cb4e0c8d7861c98e0b
ToppCellControl-Epithelial_alveolar-AT_2-AT2_Progenitor|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

C3 GRTP1 RBM47 NPNT

2.03e-051853948ca1374501eca01d8468130b74d50abfd4329fbe
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRKG2 COX4I2 NPNT KLHL23

2.03e-0518539430df02fbe2828e3c4f3e5c4cda855e74fb31be39
ToppCellfacs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C3 HSD3B7 CTSK SVEP1

2.08e-05186394a7ab70b049742dfe7ee30557031bfac6412edf52
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DRC7 ACAD8 COX4I2 RBM47

2.08e-05186394d4e327cc1d7b618654ffe0ff6475fe8e8cc5cb01
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R3C PRKG2 COX4I2 FOXC2

2.12e-05187394ddfc2d1d9fcc3d8e4d3d015576bb17eebf44ada9
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRKG2 COX4I2 NPNT KLHL23

2.12e-051873948ff9f771d10c372d771c92dfa9006aa81aec4681
ToppCellLA-01._Fibroblast_I|World / Chamber and Cluster_Paper

LGR4 BNC2 C3 SVEP1

2.12e-051873944ea486991f66c29728d127171a07b81404ec0b78
ToppCelldroplet-Kidney-nan-18m-Epithelial-kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R3C PRKG2 COX4I2 FOXC2

2.17e-05188394d1a4cd4db95d8d32b79156290f7867f32824cc87
ToppCellIPF-Stromal-SMC|World / Disease state, Lineage and Cell class

PPP1R3C COX4I2 KLHL23 FOXC2

2.17e-05188394b66264e8f8d536ed2beec31e6746c687718f239b
ToppCellIPF-Stromal-SMC|IPF / Disease state, Lineage and Cell class

PPP1R3C COX4I2 KLHL23 FOXC2

2.17e-05188394e98b24c0de41285f01f7ac194ff0a1b59fd5c333
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PPP1R3C BNC2 SVEP1 NPNT

2.21e-05189394203c80030df08ae112f9ae4043709f455d87ce89
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

C3 PRKG2 SVEP1 NPNT

2.21e-0518939440cbd679dc0548bf5207e1b033c0597886ad6fe1
ToppCelldroplet-Kidney-nan-3m-Epithelial-Stroma____kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R3C PRKG2 COX4I2 KLHL23

2.21e-05189394a959c9d6a0866582688a4204d625c1e5a123e93d
ToppCellfacs-Lung-EPCAM-24m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C3 PRKG2 SVEP1 NPNT

2.21e-05189394324c81285c51f4f8bb1aef428b18fe2c549c2c11
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BNC2 C3 CTSK SVEP1

2.21e-05189394d531399749409d614adca13d181830c6e3287508
ToppCellfacs-Lung-18m-Mesenchymal|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

C3 PRKG2 SVEP1 NPNT

2.21e-05189394bdf8db938aa0863c4fed6fa99dcffd63c8c20c31
ToppCellfacs-Lung-EPCAM-24m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C3 PRKG2 SVEP1 NPNT

2.26e-0519039400fd993675faf53adf985b9316a18c8a33242029
ToppCell10x5'v1-week_17-19-Mesenchymal_myocytic-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ELOVL4 SVEP1 NPNT FOXC2

2.26e-0519039481f8f2cddf4c51b879f315260cd1fca80355a371
ToppCell10x5'v1-week_17-19-Mesenchymal_myocytic|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ELOVL4 SVEP1 NPNT FOXC2

2.26e-05190394877b544decf302e0d41be23dffa1861f79c70914
ToppCell10x5'v1-week_17-19-Mesenchymal_myocytic-stroma-muscle|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ELOVL4 SVEP1 NPNT FOXC2

2.26e-0519039420106e5213f6a7560554b8b4f84b23c5554ba975
ToppCellfacs-Lung-EPCAM-24m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C3 PRKG2 SVEP1 NPNT

2.26e-051903948cda09d761c6b504a744959d587c183f94f1beeb
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

C3 PRKG2 SVEP1 NPNT

2.30e-051913945c4e4e9de14edfae072a2a2882220a31bebf51b2
ToppCellControl-Stromal-SMC|Stromal / Disease state, Lineage and Cell class

SEMA3F COX4I2 KLHL23 FOXC2

2.30e-051913942da83c493e60ad0278848957645277d76737a188
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

C3 PRKG2 SVEP1 NPNT

2.30e-05191394094c9d3270fc1e487ccf10fb4936af5f081f6009
ToppCellfacs-Lung-24m-Mesenchymal|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

C3 PRKG2 SVEP1 NPNT

2.30e-05191394ba02cbdfda6a94374a6472eb88499059979af472
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-alveolar_fibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

C3 PRKG2 SVEP1 NPNT

2.30e-0519139480484d39f34703a33b9bac09826b7a526e883cab
ToppCellRV-01._Fibroblast_I|RV / Chamber and Cluster_Paper

LGR4 BNC2 C3 SVEP1

2.35e-05192394356160b113c3305a61ceeaff33ce3c9da0be2878
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C3 HSD3B7 CTSK SVEP1

2.35e-05192394beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCellPericytes|World / lung cells shred on cell class, cell subclass, sample id

PPP1R3C COX4I2 KLHL23 FOXC2

2.35e-05192394057ad22b878c0c5fb59ed1412ca13db945c57a5a
ToppCellfacs-Lung-EPCAM-18m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C3 PRKG2 SVEP1 NPNT

2.35e-051923945876ff75e273a48e7ad8236423fb41e4ae4c0a91
ToppCell368C-Fibroblasts-Fibroblast-K_(Pericytes)|368C / Donor, Lineage, Cell class and subclass (all cells)

PPP1R3C COX4I2 KLHL23 FOXC2

2.40e-051933945182284dfa7c94027e94172e08f78c86b95d63f4
ToppCellPND28-Mesenchymal-Mesenchymal_structural|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C3 PRKG2 SVEP1 NPNT

2.40e-05193394ec81c1afdae2e0433a22c8c1fa1c6232526ff7e7
ToppCellLV-01._Fibroblast_I|LV / Chamber and Cluster_Paper

LGR4 BNC2 C3 SVEP1

2.40e-05193394dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCell368C-Fibroblasts-Fibroblast-K_(Pericytes)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

PPP1R3C COX4I2 KLHL23 FOXC2

2.40e-051933945ec917931b438dd0e7fb03eb6af459d3ef6b84ba
ToppCell368C-Fibroblasts-Fibroblast-K_(Pericytes)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

PPP1R3C COX4I2 KLHL23 FOXC2

2.40e-051933945260ac95a15cc43a19909badad0c7e3854da920d
ToppCellfacs-Skin-Anagen-3m-Epithelial-bulge_keratinocyte|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R3C LGR4 BNC2 NPNT

2.40e-05193394eba3c70701b051bc1ed1f4db9270cb27a77ffc3e
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C3 PRKG2 SVEP1 NPNT

2.40e-0519339430481fb01c7acf85beae10213f038da86bed6777
ToppCell368C-Fibroblasts-Fibroblast-K_(Pericytes)-|368C / Donor, Lineage, Cell class and subclass (all cells)

PPP1R3C COX4I2 KLHL23 FOXC2

2.40e-051933944f7bab0115469c855160636d168bd6e5d4e2dd2f
ToppCellCOVID-19-Heart-Fib_2|Heart / Disease (COVID-19 only), tissue and cell type

LGR4 BNC2 C3 SVEP1

2.45e-05194394d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCelldroplet-Limb_Muscle-nan-24m-Mesenchymal-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R3C YIPF7 COX4I2 KLHL23

2.45e-05194394fb234d97191c95b7880280c6e4ed5df124ffb0e1
ToppCellRV-02._Fibroblast_II|RV / Chamber and Cluster_Paper

LGR4 BNC2 C3 SVEP1

2.45e-0519439411c79a8c56ece42713b04b321982e41e239f07a5
ToppCellLA-14._Fibroblast_III|World / Chamber and Cluster_Paper

LGR4 BNC2 C3 SVEP1

2.45e-05194394803fa83ceada17c38ca9f933b888f7e7b0b90761
ToppCellLV-02._Fibroblast_II|LV / Chamber and Cluster_Paper

LGR4 BNC2 C3 SVEP1

2.45e-05194394014d2feb5db2a6a35ef759761a41e466e108c3c1
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BNC2 C3 CTSK SVEP1

2.45e-0519439435b30bc954750e939f81a9a7498b8bc2ce69a299
ToppCellfacs-Skin-Anagen-3m-Epithelial-outer_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R3C LGR4 BNC2 NPNT

2.45e-051943945d30d3d41d5f19cdf3077cc609aa2738762cb8c5
ToppCell21-Trachea-Mesenchymal-Mesenchyme_RSPO2+|Trachea / Age, Tissue, Lineage and Cell class

PPP1R3C COX4I2 CTSK SVEP1

2.45e-051943948fc98d2c9d94f3bc6292265e20ab71c4f1f37bb3
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BNC2 C3 CTSK SVEP1

2.50e-05195394f54bc4454270ff06e85596f98199372b50d0179f
ToppCellCOVID-19-Heart-Fib_1|Heart / Disease (COVID-19 only), tissue and cell type

LGR4 BNC2 C3 SVEP1

2.50e-05195394f423baa36ac7cdc383c033e35a7d17e6bf913323
ToppCellLA-02._Fibroblast_II|World / Chamber and Cluster_Paper

LGR4 BNC2 C3 SVEP1

2.50e-05195394a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCellLAM-Mesenchyme|LAM / Condition, Lineage and Cell class

PPP1R3C COX4I2 KLHL23 FOXC2

2.55e-05196394e7918b0cd5eeb675012f871f43f4388471845035
ToppCellPericytes|World / shred by cell class for parenchyma

PPP1R3C COX4I2 KLHL23 FOXC2

2.55e-051963948e7ecbe77d312a7fc6aadd8fd52c13dd1834cc7e
ToppCell(5)_Fibroblast-K_(Pericytes)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

PPP1R3C COX4I2 KLHL23 FOXC2

2.55e-05196394e3c89c5bd674289738d5590ebfd30c605f5156a5
ToppCellLAM-Mesenchyme-Mesenchyme|LAM / Condition, Lineage and Cell class

PPP1R3C COX4I2 KLHL23 FOXC2

2.55e-051963944590fb157797a68dca4295e203702bbae279cd03
ToppCellControl_saline-Epithelial_alveolar-AT_2-Differentiating_AT2|Control_saline / Treatment groups by lineage, cell group, cell type

C3 GALNT3 RBM47 NPNT

2.60e-0519739444a59dfb889577b3160a5b13ada1276771a00241
ToppCellControl_saline-Epithelial_alveolar-AT_2|Control_saline / Treatment groups by lineage, cell group, cell type

C3 GALNT3 RBM47 NPNT

2.60e-05197394b8f62fcd6eb8f47b3cc41f616126f82c68a36e87
ToppCell3'-Pediatric_IBD-SmallIntestine-Mesenchymal-stromal_related|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BNC2 C3 CTSK SVEP1

2.60e-05197394ea9332adf753d7e92f89654320543abb9e6142aa
ToppCellBronchial-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

COX4I2 NPNT KLHL23 FOXC2

2.65e-05198394705118a5db366b43ffd3389c60e4cb392ad3f2e6
ToppCell3'-Pediatric_IBD-SmallIntestine-Mesenchymal-stromal_related-T_reticular|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BNC2 C3 CTSK SVEP1

2.65e-0519839411f21a4a97da10fc6ae604cb627aa3af749d9dff
ToppCellcellseq-Mesenchymal-Myocytic-Myocytic_2|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PPP1R3C COX4I2 KLHL23 FOXC2

2.65e-05198394c7075dce915ab8387309fcb12c5f6a17d4100cda
ToppCelldistal-2-mesenchymal-Vascular_Smooth_Muscle|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

COX4I2 NPNT KLHL23 FOXC2

2.65e-05198394ce05ede69c167b2294630709bb0c223483a6ef75
ToppCelltumor_Lung-Fibroblasts-COL14A1+_matrix_FBs|tumor_Lung / Location, Cell class and cell subclass

BNC2 C3 CTSK SVEP1

2.65e-0519839474f2c7ef702b25a5b99e56121229e678ed992524
ToppCellTransplant_Alveoli_and_parenchyma-Mesenchymal-Smooth_muscle|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X

COX4I2 NPNT KLHL23 FOXC2

2.65e-0519839489986c7756541df364df516329d10775ba0e78a4
ToppCelldistal-mesenchymal-Vascular_Smooth_Muscle|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PPP1R3C COX4I2 NPNT KLHL23

2.65e-051983948d1c74a728040386316fbdcabcdea5fb2b5a76a1
ToppCellcellseq-Mesenchymal-Myocytic-Myocytic_2-VSMC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PPP1R3C COX4I2 KLHL23 FOXC2

2.65e-05198394e967c601101361fc1c48dab0e5b76dc68813276e
ToppCellBronchus_Control_(B.)-Stromal-TX-Smooth_muscle-2|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

PPP1R3C COX4I2 NPNT FOXC2

2.71e-051993942c5ad62919c64ea0242e0984bb9932d2d975f4e3
ToppCellnormal_Lung-Fibroblasts-Smooth_muscle_cells|Fibroblasts / Location, Cell class and cell subclass

COX4I2 NPNT KLHL23 FOXC2

2.71e-05199394d65847ceb68a560798df3f73e6f838e7c3e38a1c
ToppCellFibroblasts-CD34+_Fibroblasts|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

BNC2 C3 CTSK SVEP1

2.71e-0519939413ff7409e200a0b46cdb7924d15ef33639693622
ToppCellTracheal-10x3prime_v2-Stromal-Myofibroblastic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

PPP1R3C COX4I2 KLHL23 FOXC2

2.71e-05199394534dcfe8b65ad92bb8d749d1c7036ad4807e09cd
ToppCellBronchial-10x5prime-Stromal-Fibroblastic-Fibro_immune_recruiting|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

C3 COX4I2 CTSK SVEP1

2.71e-051993940cdbedf09ec72734b86ddab3fec562e066afed92
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_1-AF2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

BNC2 C3 CTSK SVEP1

2.71e-05199394993fa050a095017135a6e723c77cd38b9d782e58
ToppCelldistal-2-mesenchymal-Airway_Smooth_Muscle|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

COX4I2 NPNT KLHL23 FOXC2

2.71e-05199394af226a6c50747dad9ca696463e715913b3ac17c0
ToppCellTracheal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

PPP1R3C COX4I2 KLHL23 FOXC2

2.71e-05199394056a28c36cd58dc695a5ae6f29b62135d6aad819
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

BNC2 C3 CTSK SVEP1

2.71e-05199394f835e7ffe976843b0edbf695762d463da85793f3
ToppCellLung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-2,_SCARA5-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

BNC2 C3 CTSK SVEP1

2.76e-052003940b2614b8513693dd508c9003699049efd9abac52
ToppCell390C-Fibroblasts-Fibroblast-K_(Pericytes)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

PFKP NPNT KLHL23 FOXC2

2.76e-052003942bc7f462a551292de2501028164573935232f899
ToppCellBiopsy_IPF-Mesenchymal-Fibroblasts|Biopsy_IPF / Sample group, Lineage and Cell type

BNC2 C3 CTSK SVEP1

2.76e-05200394d8637f1e62d3fb9476dc51e1b1dc2f4b14b5fcd8
ToppCellproximal-3-mesenchymal-Airway_Smooth_Muscle|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PPP1R3C COX4I2 KLHL23 FOXC2

2.76e-05200394e9a008bfe336002218c63d1c2231986e1b237621
ToppCellproximal-mesenchymal-Airway_Smooth_Muscle|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PPP1R3C COX4I2 KLHL23 FOXC2

2.76e-052003945eeb8eb3fe74f5a8055c52ec77e38237bb63ed90
ToppCellParenchymal-10x3prime_v2-Stromal-Fibroblastic-Fibro_adventitial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

BNC2 C3 CTSK SVEP1

2.76e-05200394fc3c4778841c4b8bac0afb458352614b2c460617
Diseaseatypical hemolytic-uremic syndrome (is_implicated_in)

C3 CD46

3.81e-058352DOID:0080301 (is_implicated_in)
DiseaseC3 glomerulopathy

C3 CD46

4.89e-059352C4087273
Diseasemembranous glomerulonephritis (implicated_via_orthology)

C3 NPNT

4.89e-059352DOID:10976 (implicated_via_orthology)
DiseaseHemolytic-uremic syndrome

C3 CD46

4.89e-059352cv:C0019061
DiseaseAtypical hemolytic-uremic syndrome

C3 CD46

4.89e-059352cv:C2931788
DiseaseAtypical Hemolytic Uremic Syndrome

C3 CD46

6.11e-0510352C2931788
DiseaseHemolytic-Uremic Syndrome

C3 CD46

7.47e-0511352C0019061
Diseasepreterm premature rupture of the membranes, spontaneous preterm birth

LGR4 GALNT3

5.07e-0428352EFO_0006917, MONDO_0012511
Diseaseosteoporosis (is_implicated_in)

LGR4 CYP19A1

6.22e-0431352DOID:11476 (is_implicated_in)
DiseaseComplement deficiency disease

C3 CD46

7.05e-0433352C0272242
Diseasesleep duration

IPO5 YIPF7 PRKG2 NPNT

8.64e-04362354EFO_0005271

Protein segments in the cluster

PeptideGeneStartEntry
GCGGGYMTNAFQYVQ

CTSK

176

P43235
QMHGGYGYLKDYAVQ

ACAD8

371

Q9UKU7
FYMSQYGLYNGGGAS

BNC2

786

Q6ZN30
LMGGQVYFCYDGSPY

HSD3B7

251

Q9H2F3
YYGGGYGSTQATFMV

C3

1261

P01024
AAAAMYGGYAGYIPQ

RBM47

561

A0AV96
QGYGVMEYKAGGCYE

MORN1

96

Q5T089
YYDANQSMYVFGGCT

FBXO42

126

Q6P3S6
YQMHFICNEGYYLIG

CD46

121

P15529
GAAHGLAGIYYYLMQ

LANCL1

216

O43813
MGQCYYNETIGFFYN

LPAR2

1

Q9HBW0
QLYAFGSDYYGCMGV

NEK9

446

Q8TD19
NTYGSYKCYCLNGYM

NPNT

106

Q6UXI9
ELFMGSYNAGYSYIC

ELOVL4

96

Q9GZR5
YCGYLANMGGLAAGA

PFKP

586

Q01813
QATYQLGVMYYDGLG

LRP2BP

91

Q9P2M1
FYYDCGMYSHLQGNL

LGR4

841

Q9BXB1
EQNYYRAAGSYGGMA

FOXC2

21

Q99958
AYGLGVMAQYGGDNY

IPO5

926

O00410
VECMYGRNYQQGSYI

PRKG2

181

Q13237
GCGTQMYFYLQLGGA

OR2T10

96

Q8NGZ9
MTGKSALQYNDYGCY

PLA2G2E

31

Q9NZK7
MNGCIYVTGGYSYSK

KLHL23

506

Q8NBE8
GSACNYYNRVYGEFM

CYP19A1

71

P11511
IMYTCHGLGGNQYFE

GALNT3

531

Q14435
VGYCQGMNFIAGYLI

GRTP1

151

Q5TC63
MLIGSGYDAYCVNGY

DRC7

196

Q8IY82
MCGSYYRNYNGGHGY

KRTAP6-3

1

Q3LI67
YVKQGYMSGGAGYVL

C1GALT1

201

Q9NS00
GGKMSPYTNCYAQRY

COX4I2

31

Q96KJ9
YTDVDCVYMKNVYGG

PPP1R3C

196

Q9UQK1
YVCGTGAYNPMCTYV

SEMA3F

131

Q13275
YVVSMGSCANGGGYY

NDUFS7

146

O75251
LYGTMVSYTCNPGYE

SVEP1

2676

Q4LDE5
YSIYNTEVGYCQGMS

USP6NL

176

Q92738
FGGYRNASAYCLMYI

USP25

641

Q9UHP3
YGAGVYYNSLIMCNG

TAMM41

91

Q96BW9
QFGYVYGMSAIGCLV

YIPF7

171

Q8N8F6
VTAGDAGNYSCMYYQ

TARM1

186

B6A8C7