Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium,diacylglycerol-dependent serine/threonine kinase activity	PRKCA PRKCG	5.09e-05	2	143	2	GO:0004698
GeneOntologyMolecularFunction	histone H3T6 kinase activity	PRKCA PRKCB	5.09e-05	2	143	2	GO:0035403
GeneOntologyMolecularFunction	diacylglycerol-dependent serine/threonine kinase activity	PRKCA PRKCB PRKCG	1.88e-04	16	143	3	GO:0004697
GeneOntologyMolecularFunction	ligase activity	ACACB TTLL5 NARS1 CPS1 LIG4 ACSBG1 ACSM6	2.61e-04	174	143	7	GO:0016874
GeneOntologyMolecularFunction	C-acyltransferase activity	SPTLC3 HADHB ACSM6	4.35e-04	21	143	3	GO:0016408
GeneOntologyCellularComponent	fatty acid beta-oxidation multienzyme complex	ACACB HADHB	1.37e-04	3	142	2	GO:0036125
GeneOntologyCellularComponent	mitochondrial fatty acid beta-oxidation multienzyme complex	ACACB HADHB	1.37e-04	3	142	2	GO:0016507
GeneOntologyCellularComponent	presynaptic cytosol	ANKS1B PRKCA PRKCB PRKCG	3.41e-04	49	142	4	GO:0099523
Domain	Protein_kinase_C_a/b/g	PRKCA PRKCB PRKCG	4.12e-07	3	140	3	IPR014375
Domain	C1_1	DGKG STAC2 PRKCA PRKCB PRKCG	6.74e-05	57	140	5	PF00130
Domain	ZF_DAG_PE_1	DGKG STAC2 PRKCA PRKCB PRKCG	1.18e-04	64	140	5	PS00479
Domain	ZF_DAG_PE_2	DGKG STAC2 PRKCA PRKCB PRKCG	1.18e-04	64	140	5	PS50081
Domain	C1	DGKG STAC2 PRKCA PRKCB PRKCG	1.27e-04	65	140	5	SM00109
Domain	PE/DAG-bd	DGKG STAC2 PRKCA PRKCB PRKCG	1.36e-04	66	140	5	IPR002219
Domain	C2_dom	RPGRIP1 DYSF SYT14 OSBPL6 PRKCA PRKCB PRKCG	2.39e-04	164	140	7	IPR000008
Domain	ATP_grasp_subdomain_1	ACACB TTLL5 CPS1	3.10e-04	18	140	3	IPR013815
Domain	Nebulin	NRAP NEB	3.31e-04	4	140	2	PF00880
Domain	NEBULIN	NRAP NEB	3.31e-04	4	140	2	PS51216
Domain	NEBU	NRAP NEB	3.31e-04	4	140	2	SM00227
Domain	Nebulin	NRAP NEB	3.31e-04	4	140	2	IPR013998
Domain	Nebulin_repeat	NRAP NEB	3.31e-04	4	140	2	IPR000900
Domain	C2	RPGRIP1 DYSF SYT14 PRKCA PRKCB PRKCG	4.62e-04	131	140	6	PF00168
Domain	DAG/PE-bd	PRKCA PRKCB PRKCG	4.97e-04	21	140	3	IPR020454
Domain	CPSASE_1	ACACB CPS1	5.50e-04	5	140	2	PS00866
Domain	C2	RPGRIP1 DYSF SYT14 PRKCA PRKCB PRKCG	5.86e-04	137	140	6	SM00239
Domain	C2	RPGRIP1 DYSF SYT14 PRKCA PRKCB PRKCG	7.08e-04	142	140	6	PS50004
Domain	CPSASE_2	ACACB CPS1	8.20e-04	6	140	2	PS00867
Domain	-	RPGRIP1 DYSF SYT14 PRKCA PRKCB PRKCG	8.78e-04	148	140	6	2.60.40.150
Domain	CbamoylP_synth_lsu-like_ATP-bd	ACACB CPS1	1.14e-03	7	140	2	IPR005479
Domain	BC-like_N	ACACB CPS1	1.14e-03	7	140	2	IPR005481
Domain	CPSase_L_D2	ACACB CPS1	1.14e-03	7	140	2	PF02786
Domain	Biotin_carb_N	ACACB CPS1	1.14e-03	7	140	2	PF00289
Pathway	REACTOME_DISINHIBITION_OF_SNARE_FORMATION	PRKCA PRKCB PRKCG	4.32e-06	5	108	3	M26920
Pathway	BIOCARTA_TCR_PATHWAY	PTPN7 NFATC3 PRKCA PRKCB RAC1	2.06e-05	44	108	5	M19784
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_US27_TO_CXCR4_GNB_G_PLCB_PKC_SIGNALING_PATHWAY	PRKCA PRKCB PRKCG	2.38e-05	8	108	3	M47555
Pathway	KEGG_MEDICUS_REFERENCE_TGFA_EGFR_PLCG_PKC_SIGNALING_PATHWAY	PRKCA PRKCB PRKCG	2.38e-05	8	108	3	M47479
Pathway	KEGG_VEGF_SIGNALING_PATHWAY	NFATC3 PRKCA PRKCB PRKCG RAC1 RAC3	2.49e-05	76	108	6	M1749
Pathway	KEGG_MEDICUS_REFERENCE_TAC3_TACR3_PLC_PKC_SIGNALING_PATHWAY	PRKCA PRKCB PRKCG	5.05e-05	10	108	3	M47644
Pathway	KEGG_MEDICUS_REFERENCE_KISS1_KISS1R_PLCB_PKC_SIGNALING_PATHWAY	PRKCA PRKCB PRKCG	6.90e-05	11	108	3	M47637
Pathway	KEGG_MEDICUS_PATHOGEN_HBV_LHBS_TO_PKC_ERK_SIGNALING_PATHWAY	PRKCA PRKCB PRKCG	9.15e-05	12	108	3	M47597
Pathway	KEGG_MEDICUS_REFERENCE_TRH_TRHR_PLCB_PKC_SIGNALING_PATHWAY	PRKCA PRKCB PRKCG	9.15e-05	12	108	3	M47649
Pathway	KEGG_MEDICUS_REFERENCE_TSH_DUOX2_TG_SIGNALING_PATHWAY	PRKCA PRKCB PRKCG	9.15e-05	12	108	3	M47628
Pathway	BIOCARTA_BCR_PATHWAY	NFATC3 PRKCA PRKCB RAC1	1.12e-04	33	108	4	M9494
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY	PRKCA PRKCB PRKCG	1.18e-04	13	108	3	M47656
Pathway	PID_CD8_TCR_DOWNSTREAM_PATHWAY	STAT4 PTPN7 NFATC3 PRKCA PRKCB	1.38e-04	65	108	5	M272
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PLCG_ERK_SIGNALING_PATHWAY	PRKCA PRKCB PRKCG	1.50e-04	14	108	3	M47383
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PLCG_ERK_SIGNALING_PATHWAY	PRKCA PRKCB PRKCG	1.50e-04	14	108	3	M47384
Pathway	PID_TCR_RAS_PATHWAY	PTPN7 PRKCA PRKCB	1.50e-04	14	108	3	M134
Pathway	KEGG_WNT_SIGNALING_PATHWAY	CTNNBIP1 NFATC3 PRKCA PRKCB PRKCG RAC1 RAC3	1.59e-04	151	108	7	M19428
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_ERK_SIGNALING_PATHWAY	PRKCA PRKCB PRKCG	1.86e-04	15	108	3	M47382
Pathway	REACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD4	PRKCA PRKCB PRKCG	1.86e-04	15	108	3	M27413
Pathway	WP_WNT_SIGNALING_WP428	CTNNBIP1 NFATC3 PRKCA PRKCB PRKCG RAC1	2.29e-04	113	108	6	M39669
Pathway	REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS	PRKCA PRKCB PRKCG	2.75e-04	17	108	3	M5488
Pathway	BIOCARTA_CALCINEURIN_PATHWAY	NFATC3 PRKCA PRKCB	3.28e-04	18	108	3	MM1385
Pathway	BIOCARTA_CALCINEURIN_PATHWAY	NFATC3 PRKCA PRKCB	3.28e-04	18	108	3	M3430
Pathway	KEGG_MEDICUS_REFERENCE_CXCL12_CXCR4_PKC_ERK_SIGNALING_PATHAWAY	PRKCA PRKCB PRKCG	3.88e-04	19	108	3	M47596
Pathway	KEGG_MEDICUS_REFERENCE_GNRH_GNRHR_PLCB_PKC_SIGNALING_PATHWAY	PRKCA PRKCB PRKCG	5.26e-04	21	108	3	M47638
Pathway	BIOCARTA_ION_PATHWAY	PRKCA PRKCB	5.73e-04	5	108	2	MM1574
Pathway	BIOCARTA_PLCD_PATHWAY	PRKCA PRKCB	5.73e-04	5	108	2	MM1587
Pathway	BIOCARTA_ION_PATHWAY	PRKCA PRKCB	5.73e-04	5	108	2	M22059
Pathway	BIOCARTA_PLCD_PATHWAY	PRKCA PRKCB	5.73e-04	5	108	2	M22080
Pathway	BIOCARTA_EDG1_PATHWAY	PRKCA PRKCB RAC1	6.06e-04	22	108	3	M10579
Pathway	BIOCARTA_CREB_PATHWAY	PRKCA PRKCB RAC1	6.06e-04	22	108	3	M9070
Pathway	WP_WNT_SIGNALING_WP363	PRKCA PRKCB PRKCG RAC1	6.17e-04	51	108	4	M39721
Pathway	KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	NFATC3 PRKCA PRKCB PRKCG RAC1 RAC3	6.42e-04	137	108	6	M5669
Pathway	REACTOME_PCP_CE_PATHWAY	PRKCA PRKCB PRKCG RAC1 RAC3	6.97e-04	92	108	5	M27322
Pathway	PID_NFAT_3PATHWAY	NFATC3 PRKCA PRKCB PRKCG	7.15e-04	53	108	4	M113
Pathway	WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING	SHMT2 SLC1A6 PRKCA PRKCB PRKCG LTA	7.19e-04	140	108	6	M42572
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES	PRKCA PRKCB RAC1	7.87e-04	24	108	3	M27553
Pathway	PID_TXA2PATHWAY	PRKCA PRKCB PRKCG RAC1	8.81e-04	56	108	4	M99
Pathway	WP_HIPPO_SIGNALING_REGULATION	NF2 PRKCA PRKCB PRKCG RAC1	9.28e-04	98	108	5	M39830
Pathway	KEGG_MEDICUS_REFERENCE_CCR5_GNB_G_PLCB_G_PKC_SIGNALING_PATHWAY	PRKCA PRKCB PRKCG	1.00e-03	26	108	3	M47557
Pathway	BIOCARTA_AT1R_PATHWAY	PRKCA PRKCB RAC1	1.12e-03	27	108	3	M14899
Pathway	BIOCARTA_PYK2_PATHWAY	PRKCA PRKCB RAC1	1.12e-03	27	108	3	M7739
Pathway	BIOCARTA_ERBB4_PATHWAY	PRKCA PRKCB	1.19e-03	7	108	2	MM1563
Pathway	BIOCARTA_PKC_PATHWAY	PRKCA PRKCB	1.19e-03	7	108	2	MM1572
Pathway	BIOCARTA_ERBB4_PATHWAY	PRKCA PRKCB	1.19e-03	7	108	2	M22043
Pathway	BIOCARTA_PKC_PATHWAY	PRKCA PRKCB	1.19e-03	7	108	2	M22057
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_GH_TO_ITGA_B_RHOA_SIGNALING_PATHWAY	RAC1 RAC3	1.19e-03	7	108	2	M47538
Pathway	WP_WNT_SIGNALING	PRKCA PRKCB PRKCG RAC1	1.22e-03	61	108	4	MM15893
Pathway	PID_IL8_CXCR1_PATHWAY	PRKCA PRKCB PRKCG	1.25e-03	28	108	3	M252
Pathway	PID_ENDOTHELIN_PATHWAY	PRKCA PRKCB PRKCG RAC1	1.37e-03	63	108	4	M8
Pathway	BIOCARTA_BIOPEPTIDES_PATHWAY	PRKCA PRKCB KNG1	1.38e-03	29	108	3	M13494
Pathway	BIOCARTA_GPCR_PATHWAY	NFATC3 PRKCA PRKCB	1.38e-03	29	108	3	MM1495
Pathway	BIOCARTA_GPCR_PATHWAY	NFATC3 PRKCA PRKCB	1.53e-03	30	108	3	M9664
Pathway	WP_WNT_SIGNALING_PATHWAY	CTNNBIP1 PRKCA PRKCB RAC1 MYB	1.56e-03	110	108	5	MM15977
Pathway	KEGG_MEDICUS_REFERENCE_CXCR4_GNB_G_PLCB_PKC_SIGNALING_PATHWAY	PRKCA PRKCB PRKCG	1.68e-03	31	108	3	M47554
Pathway	REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS	PRKCA PRKCB PRKCG	1.68e-03	31	108	3	M7223
Pathway	BIOCARTA_BCR_PATHWAY	NFATC3 PRKCA PRKCB	1.85e-03	32	108	3	MM1355
Pathway	BIOCARTA_PLC_PATHWAY	PRKCA PRKCB	2.02e-03	9	108	2	M22029
Pathway	BIOCARTA_PLC_PATHWAY	PRKCA PRKCB	2.02e-03	9	108	2	MM1551
Pubmed	Cell cycle phase-specific phosphorylation of human topoisomerase II alpha. Evidence of a role for protein kinase C.	PRKCA PRKCB PRKCG TOP2A	2.90e-10	4	145	4	7499337
Pubmed	Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity.	PRKCA PRKCB PRKCG TOP2A	1.44e-09	5	145	4	12569090
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	GPHN ZNF536 HDAC5 IQGAP2 DDX52 MECOM SPAG9 CPS1 HNRNPL NSDHL UBE4A LIG4 BRD8 EIF5B ALYREF TSHZ1 TOP2A RAC1	2.10e-08	857	145	18	25609649
Pubmed	Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals.	PRKCA PRKCB PRKCG	7.10e-08	3	145	3	9814702
Pubmed	Protein and molecular characterization of hippocampal protein kinase C in C57BL/6 and DBA/2 mice.	PRKCA PRKCB PRKCG	7.10e-08	3	145	3	7760054
Pubmed	Desmosomal adhesiveness is developmentally regulated in the mouse embryo and modulated during trophectoderm migration.	PRKCA PRKCB PRKCG	7.10e-08	3	145	3	22819675
Pubmed	Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways.	PRKCA PRKCB PRKCG	7.10e-08	3	145	3	3755548
Pubmed	Phorbol diester-induced alterations in the expression of protein kinase C isozymes and their mRNAs. Analysis in wild-type and phorbol diester-resistant HL-60 cell clones.	PRKCA PRKCB PRKCG	7.10e-08	3	145	3	1714454
Pubmed	Conventional protein kinase C plays a critical role in negative regulation of CD98-induced homotypic aggregation.	PRKCA PRKCB PRKCG	7.10e-08	3	145	3	19895572
Pubmed	Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach.	PRKCA PRKCB PRKCG	7.10e-08	3	145	3	19556521
Pubmed	Calcium-Dependent Protein Kinase C Is Not Required for Post-Tetanic Potentiation at the Hippocampal CA3 to CA1 Synapse.	PRKCA PRKCB PRKCG	7.10e-08	3	145	3	27307229
Pubmed	Serine phosphorylation of syndecan-2 proteoglycan cytoplasmic domain.	PRKCA PRKCB PRKCG	2.83e-07	4	145	3	9244383
Pubmed	Protein kinase C phosphorylation of threonine at position 888 in Ca2+o-sensing receptor (CaR) inhibits coupling to Ca2+ store release.	PRKCA PRKCB PRKCG	2.83e-07	4	145	3	9694886
Pubmed	Characterization of a 7.5-kDa protein kinase C substrate (RC3 protein, neurogranin) from rat brain.	PRKCA PRKCB PRKCG	2.83e-07	4	145	3	8080473
Pubmed	Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication.	PRKCA PRKCB PRKCG	2.83e-07	4	145	3	10871288
Pubmed	Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin.	PRKCA PRKCB PRKCG	2.83e-07	4	145	3	8631738
Pubmed	Regulation of ARNO nucleotide exchange by a PH domain electrostatic switch.	PRKCA PRKCB PRKCG	2.83e-07	4	145	3	10531036
Pubmed	Protein kinase C phosphorylation of syntaxin 4 in thrombin-activated human platelets.	PRKCA PRKCB PRKCG	2.83e-07	4	145	3	10856305
Pubmed	Regulation of spontaneous meiosis resumption in mouse oocytes by various conventional PKC isozymes depends on cellular compartmentalization.	PRKCA PRKCB PRKCG	2.83e-07	4	145	3	15367584
Pubmed	Physiological regulation of Munc18/nSec1 phosphorylation on serine-313.	PRKCA PRKCB PRKCG	2.83e-07	4	145	3	12950453
Pubmed	Presynaptic Short-Term Plasticity Persists in the Absence of PKC Phosphorylation of Munc18-1.	PRKCA PRKCB PRKCG	2.83e-07	4	145	3	34290081
Pubmed	Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins.	PRKCA PRKCB PRKCG	2.83e-07	4	145	3	8662663
Pubmed	Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling.	PRKCA PRKCB PRKCG	2.83e-07	4	145	3	11063746
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	TNPO1 GPHN RPGRIP1 CCP110 HDAC5 IQGAP2 CIP2A SHMT2 E2F5 SPAG9 CEP76 AAR2 NSDHL HAUS1 BUB1 OSBPL6 EIF5B ALYREF PLS3 RAC1	6.52e-07	1321	145	20	27173435
Pubmed	A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells.	PRKCA PRKCB PRKCG	7.05e-07	5	145	3	7513693
Pubmed	Role of two conserved cytoplasmic threonine residues (T410 and T412) in CD5 signaling.	PRKCA PRKCB PRKCG	7.05e-07	5	145	3	11123317
Pubmed	Phosphorylation of vitronectin on Ser362 by protein kinase C attenuates its cleavage by plasmin.	PRKCA PRKCB PRKCG	7.05e-07	5	145	3	9030777
Pubmed	Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a.	PRKCA PRKCB PRKCG	7.05e-07	5	145	3	2590242
Pubmed	PKCα integrates spatiotemporally distinct Ca2+ and autocrine BDNF signaling to facilitate synaptic plasticity.	PRKCA PRKCB PRKCG	7.05e-07	5	145	3	30013171
Pubmed	Rapid State-Dependent Alteration in Kv3 Channel Availability Drives Flexible Synaptic Signaling Dependent on Somatic Subthreshold Depolarization.	PRKCA PRKCB PRKCG	7.05e-07	5	145	3	28228266
Pubmed	Protein kinase C regulates the phosphorylation and cellular localization of occludin.	PRKCA PRKCB PRKCG	7.05e-07	5	145	3	11502742
Pubmed	Regulation of the ErbB3 binding protein Ebp1 by protein kinase C.	PRKCA PRKCB PRKCG	7.05e-07	5	145	3	11325528
Pubmed	Protein kinase C activity regulates the onset of anaphase I in mouse oocytes.	PRKCA PRKCB PRKCG	7.05e-07	5	145	3	15229137
Pubmed	PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control.	PRKCA PRKCB PRKCG	7.05e-07	5	145	3	23824069
Pubmed	Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis.	PRKCA PRKCB PRKCG	7.05e-07	5	145	3	12519779
Pubmed	Cholecystokinin facilitates glutamate release by increasing the number of readily releasable vesicles and releasing probability.	PRKCA PRKCB PRKCG	7.05e-07	5	145	3	20392936
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	TNPO1 IQGAP2 VWA8 DDX52 SHMT2 NBN AAR2 NSDHL UBE4A VPS52 HADHB CKAP2 TOP2A	7.11e-07	560	145	13	35241646
Pubmed	Specific protein kinase C isoforms are required for rod photoreceptor differentiation.	PRKCA PRKCB PRKCG	1.41e-06	6	145	3	22171059
Pubmed	Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current.	PRKCA PRKCB PRKCG	1.41e-06	6	145	3	11306676
Pubmed	Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor.	PRKCA PRKCB PRKCG	1.41e-06	6	145	3	8940188
Pubmed	Localization of protein kinase C isoforms in the optic pathway of mouse embryos and their role in axon routing at the optic chiasm.	PRKCA PRKCB PRKCG	1.41e-06	6	145	3	24863469
Pubmed	Expression and activity of protein kinase C isoenzymes during normal and abnormal murine palate development.	PRKCA PRKCB PRKCG	1.41e-06	6	145	3	10879655
Pubmed	The use of fluorescent phorbol esters in studies of protein kinase C-membrane interactions.	PRKCA PRKCB PRKCG	1.41e-06	6	145	3	12093536
Pubmed	An immunohistochemical study of protein kinase C distribution in fetal mouse vertebral column.	PRKCA PRKCB PRKCG	1.41e-06	6	145	3	7985811
Pubmed	PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5.	PRKCA PRKCB PRKCG	1.41e-06	6	145	3	30485813
Pubmed	Sequence determinants on the NR2A and NR2B subunits of NMDA receptor responsible for specificity of phosphorylation by CaMKII.	PRKCA PRKCB PRKCG	2.45e-06	7	145	3	12147342
Pubmed	The myristoylated alanine-rich C-kinase substrate (MARCKS) is sequentially phosphorylated by conventional, novel and atypical isotypes of protein kinase C.	PRKCA PRKCB PRKCG	2.45e-06	7	145	3	7588787
Pubmed	Protein kinase C isoforms differentially phosphorylate human choline acetyltransferase regulating its catalytic activity.	PRKCA PRKCB PRKCG	2.45e-06	7	145	3	15381704
Pubmed	Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.	PRKCA PRKCB PRKCG	2.45e-06	7	145	3	12958364
Pubmed	14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells.	PRKCA PRKCB PRKCG	2.45e-06	7	145	3	10433554
Pubmed	Conventional protein kinase C-α (PKC-α) and PKC-β negatively regulate RIG-I antiviral signal transduction.	PRKCA PRKCB PRKCG	2.45e-06	7	145	3	22114345
Pubmed	Activation of annexin 7 by protein kinase C in vitro and in vivo.	PRKCA PRKCB PRKCG	2.45e-06	7	145	3	11278415
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	CCP110 MED29 CIP2A TTLL5 MECOM NBN SPAG9 CEP76 BRD8 HAUS1 HADHB CKAP2 AKR1B1	3.36e-06	645	145	13	25281560
Pubmed	Developmental expression of MARCKS and protein kinase C in mice in relation to the exencephaly resulting from MARCKS deficiency.	PRKCA PRKCB PRKCG	3.91e-06	8	145	3	8922669
Pubmed	PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments.	PRKCA PRKCB PRKCG	3.91e-06	8	145	3	12134071
Pubmed	Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C.	PRKCA PRKCB PRKCG	3.91e-06	8	145	3	14699138
Pubmed	Glycogen synthase kinase-3: properties, functions, and regulation.	PRKCA PRKCB PRKCG	3.91e-06	8	145	3	11749387
Pubmed	Distribution of the extended family of protein kinase C isoenzymes in fetal organs of mice: an immunohistochemical study.	PRKCA PRKCB PRKCG	3.91e-06	8	145	3	7606770
Pubmed	Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein.	PRKCA PRKCB PRKCG	3.91e-06	8	145	3	12551925
Pubmed	Protein-protein interaction of zinc finger LIM domains with protein kinase C.	PRKCA PRKCB PRKCG	3.91e-06	8	145	3	8940095
Pubmed	The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development.	PRKCA PRKCB PRKCG	3.91e-06	8	145	3	10882525
Pubmed	Protein kinase C phosphorylation of the metabotropic glutamate receptor mGluR5 on Serine 839 regulates Ca2+ oscillations.	PRKCA PRKCB PRKCG	3.91e-06	8	145	3	15894802
Pubmed	Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation.	PRKCA PRKCB PRKCG	3.91e-06	8	145	3	10212259
Pubmed	Induction of the Galpha(q) signaling cascade by the human immunodeficiency virus envelope is required for virus entry.	PRKCA PRKCB RAC1	3.91e-06	8	145	3	18632858
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	GPHN SFPQ NYAP2 ACACB VWA8 ANKS1B DGKG ANO8 GSTM1 PLAA ACSBG1 CNTNAP2 MAP3K10 PRKCA PRKCB PRKCG HADHB	5.82e-06	1139	145	17	36417873
Pubmed	Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2.	PRKCA PRKCB PRKCG	5.85e-06	9	145	3	14654844
Pubmed	Regulation of HIV-1 gag protein subcellular targeting by protein kinase C.	PRKCA PRKCB PRKCG	5.85e-06	9	145	3	7876252
Pubmed	Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction.	PRKCA PRKCB PRKCG	5.85e-06	9	145	3	12054501
Pubmed	Cypher, a striated muscle-restricted PDZ and LIM domain-containing protein, binds to alpha-actinin-2 and protein kinase C.	PRKCA PRKCB PRKCG	5.85e-06	9	145	3	10391924
Pubmed	Phosphorylation of HIV-1 gag proteins by protein kinase C.	PRKCA PRKCB PRKCG	5.85e-06	9	145	3	8473314
Pubmed	Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes.	PRKCA PRKCB PRKCG	5.85e-06	9	145	3	11700305
Pubmed	aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb.	PRKCA PRKCB PRKCG	5.85e-06	9	145	3	17203073
Pubmed	Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein.	PRKCA PRKCB PRKCG	5.85e-06	9	145	3	7850771
Pubmed	Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report.	PRKCA PRKCB PRKCG	5.85e-06	9	145	3	8206685
Pubmed	Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion.	PRKCA PRKCB PRKCG	5.85e-06	9	145	3	10194441
Pubmed	The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway.	PRKCA PRKCB PRKCG	8.34e-06	10	145	3	1970444
Pubmed	Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtkγ.	PRKCA PRKCB PRKCG	8.34e-06	10	145	3	21482705
Pubmed	Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.	PRKCA PRKCB PRKCG	8.34e-06	10	145	3	11884598
Pubmed	Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A.	PRKCA PRKCB PRKCG	8.34e-06	10	145	3	11035810
Pubmed	Human immunodeficiency virus induces phosphorylation of its cell surface receptor.	PRKCA PRKCB PRKCG	8.34e-06	10	145	3	3259291
Pubmed	Effect of serine and tyrosine phosphorylation on retroviral proteinase substrates.	PRKCA PRKCB PRKCG	8.34e-06	10	145	3	10491200
Pubmed	Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41.	PRKCA PRKCB PRKCG	8.34e-06	10	145	3	2139676
Pubmed	Differential impact of Lhx2 deficiency on expression of class I and class II odorant receptor genes in mouse.	OR52K1 OR51G1 OR52K2 OR52B2	1.08e-05	33	145	4	17350283
Pubmed	Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol.	PRKCA PRKCB PRKCG	1.14e-05	11	145	3	14613966
Pubmed	IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C.	PRKCA PRKCB PRKCG	1.14e-05	11	145	3	8599832
Pubmed	Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C.	PRKCA PRKCB PRKCG	1.14e-05	11	145	3	2182321
Pubmed	Phosphorylation of tau is regulated by PKN.	PRKCA PRKCB PRKCG	1.14e-05	11	145	3	11104762
Pubmed	In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46.	PRKCA PRKCB PRKCG	1.14e-05	11	145	3	8914829
Pubmed	Expression profile of protein kinase C isozymes in preimplantation mouse development.	PRKCA PRKCB PRKCG	1.14e-05	11	145	3	16183862
Pubmed	HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and -delta.	PRKCA PRKCB PRKCG	1.52e-05	12	145	3	11919157
Pubmed	Involvement of protein kinase C in HIV-1 gp120-induced apoptosis in primary endothelium.	PRKCA PRKCB PRKCG	1.52e-05	12	145	3	11141237
Pubmed	HIV-1 Tat and AIDS-associated cancer: targeting the cellular anti-cancer barrier?	PRKCA PRKCB PRKCG	1.52e-05	12	145	3	18577246
Pubmed	c-FLIPL regulates PKC via AP-2 to inhibit Bax-mediated apoptosis induced by HIV-1 gp120 in Jurkat cells.	PRKCA PRKCB PRKCG	1.52e-05	12	145	3	19363595
Pubmed	Distinct and complementary roles for α and β isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose.	PRKCA PRKCB	1.73e-05	2	145	2	26660275
Pubmed	Activation mechanisms of conventional protein kinase C isoforms are determined by the ligand affinity and conformational flexibility of their C1 domains.	PRKCA PRKCG	1.73e-05	2	145	2	12954613
Pubmed	Insulin inhibits phagocytosis in normal human neutrophils via PKCalpha/beta-dependent priming of F-actin assembly.	PRKCA PRKCB	1.73e-05	2	145	2	16673150
Pubmed	Heterogeneity of cellular proliferation within transitional cell carcinoma: correlation of protein kinase C alpha/betaI expression and activity.	PRKCA PRKCB	1.73e-05	2	145	2	16517978
Pubmed	Rac-deficient cerebellar granule neurons die before they migrate to the internal granule layer.	RAC1 RAC3	1.73e-05	2	145	2	36050459
Pubmed	Rac1 and Rac3 have opposite functions in Schwann cells during developmental myelination.	RAC1 RAC3	1.73e-05	2	145	2	33812927
Pubmed	Identification of a Protein Network Driving Neuritogenesis of MGE-Derived GABAergic Interneurons.	RAC1 RAC3	1.73e-05	2	145	2	28066185
Interaction	AGAP2 interactions	GPHN IQGAP2 NMRAL1 ANKS1B NF2 CNTNAP2 PRKCA PRKCB PRKCG RAC1	1.55e-06	210	135	10	int:AGAP2
Interaction	SCP2 interactions	SFPQ HDAC5 VWA8 HNRNPL MYO5C PRKCA	7.45e-06	70	135	6	int:SCP2
Cytoband	11p15.4	OR52B4 OR52K1 OR51Q1 OR51G1 OR52K2 OR52B2	4.46e-05	200	145	6	11p15.4
GeneFamily	C2 domain containing protein kinases	PRKCA PRKCB PRKCG	1.40e-05	10	90	3	835
GeneFamily	Olfactory receptors, family 52	OR52B4 OR52K1 OR52K2 OR52B2	1.03e-04	49	90	4	165
GeneFamily	WD repeat domain containing\|F-box and WD repeat domain containing	FBXW10B FBXW10	1.31e-03	11	90	2	559
GeneFamily	Olfactory receptors, family 51	OR51Q1 OR51G1 OR51B2	1.36e-03	44	90	3	164
Coexpression	KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP	SLC25A21 SFPQ POLA1 NBN E2F5 METTL4 GFM2 HNRNPL GSTM1 SPPL2A PLAA HAUS1 NFATC3 BUB1 CNTNAP2 EIF5B PRKCB ALYREF CKAP2 TOP2A RAC1 MYB	1.56e-06	1290	141	22	M80
Coexpression	FEVR_CTNNB1_TARGETS_DN	CCP110 SFPQ POLA1 CIP2A NMRAL1 E2F5 GSTM1 SPPL2A BUB1 CKAP2 AKR1B1 TOP2A MYB	1.00e-05	555	141	13	M2343
Coexpression	GSE24634_IL4_VS_CTRL_TREATED_NAIVE_CD4_TCELL_DAY10_UP	TDRD1 STAT4 NFATC3 BUB1 CKAP2 MERTK TOP2A MYB	1.24e-05	198	141	8	M4639
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_1000_k-means-cluster#4	CCP110 ZNF536 IQGAP2 NCKAP5 CEP76 FRMD4B UBE4A ACSBG1 CNTNAP2	1.33e-05	225	134	9	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_1000_K4
CoexpressionAtlas	facebase_RNAseq_e10.5_OlfacPit_2500_K0	CCP110 ZNF536 ISYNA1 CIP2A NMRAL1 NCKAP5 E2F5 CEP76 ACVR1C FRMD4B NSDHL BUB1 OSBPL6 LRP4 TSHZ1 IL36G RAC3 MYB	2.15e-05	926	134	18	facebase_RNAseq_e10.5_OlfacPit_2500_K0
ToppCell	10x5'-Lung-Myeloid_Dendritic-Cycling_Dendritic\|Lung / Manually curated celltypes from each tissue	NIPSNAP3B LMCD1 POLA1 CIP2A NCKAP5 TRUB1 CKAP2 TOP2A	9.80e-08	173	144	8	62e0c18cfed9645e34a9d7029c94a8554f773714
ToppCell	droplet-Spleen-nan-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 SLC25A21 POLA1 BUB1 CKAP2 TOP2A MYB	2.70e-06	188	144	7	1a3f95b4fd7611c634666761ddf21f1e58e56af8
ToppCell	COVID-19_Severe-HSPC\|COVID-19_Severe / disease group, cell group and cell class	SPTLC3 ISYNA1 NAP1L3 MECOM SLC1A6 MYO5C MYB	2.79e-06	189	144	7	96015439971e2e5b8d6294ca5a6b873c7774e925
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|LV / Chamber and Cluster_Paper	NRAP ACACB VWA8 DGKG NCKAP5 NCEH1 HADHB	3.10e-06	192	144	7	ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell	COVID-19-kidney-Proliferating_T_cell\|kidney / Disease (COVID-19 only), tissue and cell type	CIP2A STAT4 PTPN7 BUB1 PRKCB TOP2A MYB	3.43e-06	195	144	7	7e05e56f8d0a7a052830c7db12b10dace7d10760
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CIP2A BRD8 BUB1 TSHZ1 CKAP2 PLS3 TOP2A	3.67e-06	197	144	7	29b0a5927f80455eef7b793feabef69fba1a3df1
ToppCell	LPS_only-Endothelial-Endothelial-FOXM1\|LPS_only / Treatment groups by lineage, cell group, cell type	CCP110 CIP2A FICD BUB1 OSBPL6 CKAP2 TOP2A	3.67e-06	197	144	7	038fd92750257d43d5e980fd06d77742b543f11a
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-cycling_ENCC/glia\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF536 SASH1 TSHZ1 CKAP2 SLITRK6 PLS3 TOP2A	3.80e-06	198	144	7	a11ac83dbd69d1c068971266d7c7343d114a6294
ToppCell	Control-Control-Myeloid-immature_Neutrophil\|Control / Disease, condition lineage and cell class	CCP110 NSDHL CRY1 BUB1 CKAP2 TOP2A MYB	4.06e-06	200	144	7	118321ac443feb42aee171baccfc4610f00a8822
ToppCell	critical-Epithelial-FOXN4+\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ISYNA1 KITLG BUB1 ALYREF EPS8L3 TOP2A MYB	4.06e-06	200	144	7	f39db4250ce220a3eb58edee3f7fc3671701d46f
ToppCell	LPS-IL1RA-Hematopoietic_Mast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IQGAP2 STAT4 PTPN7 ACSBG1 PRKCB MYB	6.93e-06	142	144	6	f7d0d5ca9fc3dd929d4fdd59b71bfa623007e992
ToppCell	LPS-IL1RA-Hematopoietic_Mast-Mast_cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IQGAP2 STAT4 PTPN7 ACSBG1 PRKCB MYB	6.93e-06	142	144	6	2a9a070e7c53ac593d46c6c5f6983f07d4413501
ToppCell	LPS-antiTNF-Hematopoietic_Mast-Mast_cells-Mast-cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IQGAP2 ERN2 PTPN7 ACSBG1 PRKCB MYB	7.51e-06	144	144	6	013223bb2f31eb5bebdbd0908b797d28b96c6f7b
ToppCell	Ciliated_cells-B-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	ZNF536 NAP1L3 OSBPL6 SLITRK6 SPAG17 MORN5	9.12e-06	149	144	6	6399c5a2f06d79f020dece252526f1c0c110d569
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SPTLC3 IQGAP2 HEPACAM2 NSDHL HAUS1 SLC4A9	9.12e-06	149	144	6	61d84838a841ed2d6b8c5f86d423a4e6b3dcc9cb
ToppCell	mild_COVID-19_(asymptomatic)-NK_CD56bright\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	SPTLC3 ISYNA1 CPS1 NEB GSTM1 FSIP2	9.85e-06	151	144	6	2470162f4b56bc505db166a6eb0fa54847759df8
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GPHN SPTLC3 IQGAP2 HEPACAM2 STAC2 SLC4A9	1.63e-05	165	144	6	dc570154baed59ed109e5369589448e075ba66a9
ToppCell	control-Epithelial-Ionocyte\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SPTLC3 ZNF383 SLC25A21 NCKAP5 HEPACAM2 STAC2	1.63e-05	165	144	6	5cfba9a46bd8ceeca74a6493057b4d38af6b06fe
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CIP2A BUB1 EPS8L3 CKAP2 TOP2A MYB	1.74e-05	167	144	6	50c29ea660bf07b890e4ac1a1985d0761d863dee
ToppCell	VE-Treg-exh_CD4\|VE / Condition, Cell_class and T cell subcluster	CCP110 LMCD1 ANKS1B GFM2 ANO8 AAR2	1.74e-05	167	144	6	1036ac1ef9440612500137af9d1929672b077e4d
ToppCell	control-Epithelial-Ionocyte\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SPTLC3 ZNF383 SLC25A21 NCKAP5 HEPACAM2 STAC2	1.80e-05	168	144	6	327b02f19f4a8607c033203824fdc60a1254331f
ToppCell	Thalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Thalamus / BrainAtlas - Mouse McCarroll V32	ACVR1C MYO5C PRKCG SLITRK6 FAM237B	1.85e-05	100	144	5	20675fc2ffc5ab63047d38da083b50d470f3db19
ToppCell	Thalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6\|Thalamus / BrainAtlas - Mouse McCarroll V32	ACVR1C MYO5C PRKCG SLITRK6 FAM237B	1.85e-05	100	144	5	1de3895e16f14ff32b901b18ce14d965afaa7e76
ToppCell	Thalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Rora\|Thalamus / BrainAtlas - Mouse McCarroll V32	ACVR1C MYO5C PRKCG SLITRK6 FAM237B	1.85e-05	100	144	5	ff1bdb511700a041a90034d1d30dfc25f51d6c82
ToppCell	COVID-19-Heart-CM_+_Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	NRAP IQGAP2 NCKAP5 FRMD4B PRKCB MERTK	1.93e-05	170	144	6	4232fe937909f93d3736988c707b8f95ce993398
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IQGAP2 METTL4 STAT4 PTPN7 NFATC3 LTA	1.99e-05	171	144	6	246fc7edcefc47437d1df6029f295aca3b34b2b2
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-Ly6g5b+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IQGAP2 METTL4 STAT4 PTPN7 NFATC3 LTA	1.99e-05	171	144	6	1fb4e11f92b48dc2d6e553c22e2571bbd8c223c6
ToppCell	droplet-Lung-nan-21m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO5C KY OSBPL6 CFAP57 SPAG17 MORN5	2.27e-05	175	144	6	3ed22ea41810e73c02db4f2d03745e4ce7e43bb1
ToppCell	droplet-Lung-nan-21m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO5C KY OSBPL6 CFAP57 SPAG17 MORN5	2.27e-05	175	144	6	8fb1e5f6aa68274adf322401db8c7b80e8c554d7
ToppCell	Ciliated_cells-A-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	ZNF536 OSBPL6 CFAP57 SLITRK6 SPAG17 MORN5	2.35e-05	176	144	6	1c364155f46b9a7c995bdc2cc2333c437cd90f5b
ToppCell	3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Differentiating_glia\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF536 VXN ANKS1B ACSBG1 NCEH1 SLITRK6	2.42e-05	177	144	6	0417460bdb012bc43d7254377fa53d79cdab3f34
ToppCell	Ciliated_cells-B-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	ZNF536 OSBPL6 CFAP57 SLITRK6 SPAG17 MORN5	2.42e-05	177	144	6	c38138fb5ad9766c2d240811210c854338cd612e
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-B_cells-Pre-B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	E2F5 IGLV4-69 LIG4 PRKCB PRKCG MYB	2.50e-05	178	144	6	34ef4d36ddfb1cdeaaaf5d952e1ad6dc2785ce1e
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFPQ FMO2 NUP210L SPAG9 PARP14 KITLG	2.50e-05	178	144	6	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GPHN SPTLC3 IQGAP2 HEPACAM2 STAC2 SLC4A9	2.50e-05	178	144	6	51d2188406f04329311b2efd1108fc36617a860e
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NUP210L CIP2A DYSF BUB1 CKAP2 TOP2A	2.50e-05	178	144	6	ea10117026021c959ffc871fc377cdb3e161d264
ToppCell	15-Airway-Epithelial-Multiciliated_precursor\|Airway / Age, Tissue, Lineage and Cell class	MYO5C DNAH17 ERICH2 CFAP57 SPAG17 MORN5	2.50e-05	178	144	6	d8e0a696bdd6af6422d72af0413f9dbd6bc02afa
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC25A21 IQGAP2 ANKS1B NCKAP5 FRMD4B OSBPL6	2.58e-05	179	144	6	d1ef7e1cb00336118e387b47f4f8120f53584391
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF383 NCKAP5 STAT4 BUB1 CKAP2 KNG1	2.58e-05	179	144	6	4166c4e1a8748a79ac6a11fd0b97c5344be2321b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GPHN SPTLC3 IQGAP2 HEPACAM2 STAC2 SLC4A9	2.66e-05	180	144	6	cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-secretory_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIP2A STAT4 BUB1 CKAP2 PLS3 TOP2A	2.75e-05	181	144	6	b203b616584cdbd0bbb0e382b2916d0bd49d3526
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIP2A STAT4 BUB1 CKAP2 PLS3 TOP2A	2.75e-05	181	144	6	c748c16fd20d1949d33ff6290dc9d9016c4dc86c
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNF536 LMCD1 ANKS1B LRP4 TSHZ1 SLITRK6	2.92e-05	183	144	6	12daaea821e49bc94a01e2496331e92a80d27339
ToppCell	PBMC-Control-Myeloid-Neutrophil-immature_Neutrophil\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NSDHL CRY1 BUB1 CKAP2 TOP2A MYB	3.01e-05	184	144	6	a8c6028d745aaa6ee7842259238694cb50ce0526
ToppCell	PBMC-Control-Myeloid-Neutrophil-immature_Neutrophil-Neu_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NSDHL CRY1 BUB1 CKAP2 TOP2A MYB	3.01e-05	184	144	6	081d045f3bc98a36f342de7d50f39c9a888dd7eb
ToppCell	Control-Myeloid_G-immature_Neutrophil\|Control / Disease group, lineage and cell class	NSDHL CRY1 BUB1 CKAP2 TOP2A MYB	3.01e-05	184	144	6	45f873236f7e90fb78c8e291d3b5b92d121acec9
ToppCell	PBMC-Control-Myeloid-Neutrophil-immature_Neutrophil\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	NSDHL CRY1 BUB1 CKAP2 TOP2A MYB	3.01e-05	184	144	6	84c20730cd92b9aaa50077d7b625e37e7f9e91d2
ToppCell	PBMC-Control-Myeloid-Neutrophil-immature_Neutrophil-Neu_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NSDHL CRY1 BUB1 CKAP2 TOP2A MYB	3.01e-05	184	144	6	d31d4116d1d196633784863781fa45673607a421
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCP110 POLA1 BUB1 NCEH1 CKAP2 TOP2A	3.01e-05	184	144	6	16aa8e88bdd51b1d132d5cf33c29963b384a8bae
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-cycling_ENCC/glia\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CIP2A ANKS1B ANKRD18B BUB1 CKAP2 TOP2A	3.10e-05	185	144	6	282b3de8850f3c21704339e8d8737b432a43441a
ToppCell	15-Trachea-Epithelial-Multiciliated_precursor\|Trachea / Age, Tissue, Lineage and Cell class	ISYNA1 MYO5C ERICH2 SPAG17 TOP2A MYB	3.10e-05	185	144	6	9a8b8360d99375b726ca8e3c9a3f9b08919892d7
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM HEPACAM2 STAC2 KITLG PRKCA SLC4A9	3.10e-05	185	144	6	3d73b3e0bceb192257e5cfbe64b7ccb379b6e22d
ToppCell	COPD-Stromal-Pericyte\|Stromal / Disease state, Lineage and Cell class	SASH1 DGKG NCKAP5 FRMD4B STAT4 MERTK	3.30e-05	187	144	6	406ecd1dabb3ed8d871aef159f7bd1e383434953
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	ACACB VWA8 DGKG NCKAP5 NCEH1 HADHB	3.30e-05	187	144	6	78cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCell	COVID-19-kidney-T-cells-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GFM2 STAT4 PTPN7 PRKCB LTA MYB	3.40e-05	188	144	6	15484c05cb496cd98ed3f79a6134c5cec8f09a4d
ToppCell	(1)_T_CD4_reg\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	LMCD1 ANKS1B MYO5C PTPN7 KNG1 MYB	3.50e-05	189	144	6	28f28672fd260bb2a8d64152737a7242347c3174
ToppCell	facs-Trachea-3m-Hematologic-lymphocytic-T_cell-T_cell_of_trachea\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STAT4 PTPN7 BUB1 PRKCB TOP2A MYB	3.50e-05	189	144	6	286fcf22a2766cf435cd22f0986b1ca007d5b75a
ToppCell	COVID-19_Severe-HSPC\|World / disease group, cell group and cell class	ISYNA1 NAP1L3 MECOM SLC1A6 MYO5C MYB	3.50e-05	189	144	6	555c0b13f1508b9e3712b36d77144e73e828bc76
ToppCell	facs-Trachea-3m-Hematologic-lymphocytic\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STAT4 PTPN7 BUB1 PRKCB TOP2A MYB	3.50e-05	189	144	6	815631878564b805f3dc30877c5804c3ddb8641b
ToppCell	facs-Trachea-3m-Hematologic-lymphocytic-T_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STAT4 PTPN7 BUB1 PRKCB TOP2A MYB	3.50e-05	189	144	6	035e5af872fcb8b527fa85dbcaa56e3aaff24531
ToppCell	NS-critical-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ISYNA1 KITLG BUB1 CNTNAP2 EPS8L3 MYB	3.60e-05	190	144	6	7be0f2ff86ca8500a43e0d44e5e292530f9ba0bb
ToppCell	(1)_T_cells-(1)_T_CD4_reg\|(1)_T_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)	LMCD1 ANKS1B SHMT2 MYO5C RAC1 MYB	3.60e-05	190	144	6	ff42af092173c2d4472bb9a02f5a334c272e05a0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM HEPACAM2 STAC2 KITLG PRKCA SLC4A9	3.60e-05	190	144	6	b3bccf4dd95e986db3cee324a6737f5fcc22e8e5
ToppCell	(02)_Cycling_Basal_(regeneration)\|World / shred by cell type and Timepoint	CIP2A SHMT2 BUB1 ALYREF CKAP2 TOP2A	3.60e-05	190	144	6	53f017a11ca5ebe9025558e12cedc409cab2e5aa
ToppCell	NS-moderate-d_16-33-Epithelial-FOXN4+\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CCP110 ISYNA1 KITLG BUB1 EPS8L3 MYB	3.60e-05	190	144	6	250ca4a605c1cccd77d23383e4fe6f91cf3609ba
ToppCell	hematopoetic_progenitors\|World / Lineage and Cell class	ISYNA1 MECOM SLC1A6 MYO5C RAC3 MYB	3.71e-05	191	144	6	bc77789297974587d51f9e4fae22cea5f499354d
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Prolif_T-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CIP2A STAT4 BUB1 PRKCB ALYREF TOP2A	3.71e-05	191	144	6	912e2d10d3423aa7f708fcf2b11da1845f12d7d3
ToppCell	(04)_Pre-ciliated\|World / shred by cell type and Timepoint	CCP110 ISYNA1 CEP76 MORN5 TOP2A MYB	3.71e-05	191	144	6	37cf121e6e80760c8519075b7845b9029958a988
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Prolif_T\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CIP2A STAT4 BUB1 PRKCB ALYREF TOP2A	3.71e-05	191	144	6	77a2746b6d9c53b08d4405411c16fcc5a6c734ce
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEPACAM2 KY CNTNAP2 PRKCA PRKCB SLITRK6	3.82e-05	192	144	6	5b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SPTLC3 ZNF536 LMCD1 ANKS1B LRP4 SLITRK6	3.82e-05	192	144	6	72881b280a415e65f87a80ca1369cbb0b722a0c4
ToppCell	NS-moderate-d_0-4-Lymphoid\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	STAT4 PTPN7 BUB1 CNTNAP2 PRKCB TOP2A	3.82e-05	192	144	6	905217dcfc843d3469e9e71bd33707863b14cc82
ToppCell	human_hepatoblastoma-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	POLA1 CIP2A BUB1 PRKCA CKAP2 TOP2A	3.93e-05	193	144	6	4b9fa2a4424f8abe63fa7bee78db93dda04ab15f
ToppCell	PSB-critical-LOC-Epithelial-FOXN4+\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ISYNA1 BUB1 CNTNAP2 EPS8L3 TOP2A MYB	3.93e-05	193	144	6	b7d9c5bed524423e92f01496a9f8fad11b33a3f7
ToppCell	facs-Thymus-nan-3m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFPQ HNRNPL LIG4 NFATC3 PRKCB MYB	4.05e-05	194	144	6	f1661f9f2439fca5c1012c693b0744c4e3b90a9b
ToppCell	moderate-Epithelial-FOXN4+\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CCP110 ISYNA1 MYO5C KITLG EPS8L3 MYB	4.05e-05	194	144	6	5dffa578149104dda33774361e9e77b227b5f1ce
ToppCell	facs-Thymus-nan\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFPQ HNRNPL LIG4 NFATC3 PRKCB MYB	4.05e-05	194	144	6	cda1b197efb199330ea7ab25a7cee22cae22589d
ToppCell	Control-Myeloid-MoAM4\|Myeloid / Condition, Lineage and Cell class	LRRK1 FRMD4B IGLV2-14 PTPN7 PRKCA PRKCB	4.05e-05	194	144	6	7ab808dd1876b0eec2831caa16d04fd859b1dc50
ToppCell	facs-Thymus-nan-3m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFPQ HNRNPL LIG4 NFATC3 PRKCB MYB	4.05e-05	194	144	6	66c056232ac216780acf4cc8ea325bd8ed1909c9
ToppCell	droplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	POLA1 CIP2A BUB1 NCEH1 CKAP2 TOP2A	4.16e-05	195	144	6	c1435e61e4f0cf457f26ae436936048932ceb0db
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIP2A NMRAL1 LIG4 BUB1 CKAP2 TOP2A	4.16e-05	195	144	6	294c74336fafc1bad237d851efb4a487475078eb
ToppCell	facs-Thymus-nan-3m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFPQ DGKG LIG4 NFATC3 PRKCB MYB	4.16e-05	195	144	6	79114b3c78cc15c413bb58f0673e7215b784a9b6
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SFPQ CIP2A BRD8 BUB1 CKAP2 TOP2A	4.16e-05	195	144	6	742c82c86487314cdb3178012004adb1164bcbdb
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-late_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIP2A NMRAL1 LIG4 BUB1 CKAP2 TOP2A	4.16e-05	195	144	6	5749ea833be84e262e3d0a4fe1a9a373f0ef545f
ToppCell	Basal_cells\|World / lung cells shred on cell class, cell subclass, sample id	ISYNA1 FMO2 ANKRD18B LRP4 SLITRK6 AKR1B1	4.41e-05	197	144	6	24360b660000bdfb999d58fbf4e29585a97e1785
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DGKG E2F5 FPGT HEPACAM2 ANKRD18B MYB	4.41e-05	197	144	6	fd76cc5e12c7e7943a48f739e4f0626ff7211f51
ToppCell	(4)_Endothelial_cells-(41)_EC-arteriolar\|(4)_Endothelial_cells / Cell class and subclass of bone marrow stroma cells in homeostatis	LMCD1 MECOM FRMD4B KITLG LRP4 PLS3	4.41e-05	197	144	6	482e3f8926880afed88ed37553ed2b5ed58b8c99
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_Prolif-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CIP2A IRX6 BUB1 ALYREF CKAP2 TOP2A	4.41e-05	197	144	6	196eaecef7003ed83f323c1f157c6a3594650097
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CIP2A BUB1 ALYREF CKAP2 PLS3 TOP2A	4.53e-05	198	144	6	1fa213e79d828bff6465bde116536dd1b80d94e0
ToppCell	5'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SFPQ CIP2A BRD8 BUB1 CKAP2 TOP2A	4.53e-05	198	144	6	c3dd887c95587f930b7afd32385627a9fa029ca4
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CIP2A CLVS1 BUB1 ALYREF CKAP2 TOP2A	4.53e-05	198	144	6	7225a6194c52b01c581e58d3cda107c4af96dc4f
ToppCell	MS-IIF-Others-HSPC\|IIF / Disease, condition lineage and cell class	SPTLC3 ISYNA1 NIPSNAP3B MYO5C PLS3 MYB	4.66e-05	199	144	6	3384db80f6024bcabe2625f24d5f4e0d3d8caa7e
ToppCell	18-Airway-Mesenchymal-Mesenchyme_RSPO2+\|Airway / Age, Tissue, Lineage and Cell class	CIP2A ANKS1B BUB1 PRKCB CKAP2 TOP2A	4.66e-05	199	144	6	7ac35e8f45dcdc702422dabd8f3e4d03e2bf61af
ToppCell	COVID-19-COVID-19_Severe-Others-HSPC\|COVID-19_Severe / Disease, condition lineage and cell class	SPTLC3 ISYNA1 NAP1L3 MYO5C RAC3 MYB	4.66e-05	199	144	6	25de67b6c9c8d6bb9a538e071a40ef865906c95d
ToppCell	distal-1-Epithelial-Proliferating_Basal\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLC25A21 CPS1 NEB FAM83C BUB1 TOP2A	4.66e-05	199	144	6	93450257180d918c310bca7b5defc74390c48091
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	IQGAP2 LMCD1 ANKS1B LRP4 TSHZ1 SLITRK6	4.66e-05	199	144	6	38cfd367ee8c074c11ba54edeb7a001e375e2687
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	ZNF536 IQGAP2 E2F5 PRKCB ALYREF TOP2A	4.66e-05	199	144	6	358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-Glial_immature-cycling_ENCC/glia\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF536 SASH1 CKAP2 SLITRK6 PLS3 TOP2A	4.66e-05	199	144	6	9940f347973bf976ee23fb4b1cf1f349d96c21df
ToppCell	distal-Epithelial-Proliferating_Basal\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLC25A21 CPS1 NEB FAM83C BUB1 TOP2A	4.79e-05	200	144	6	25cc494ef831511840d8c02ec1bd086635cc7edd
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	LMCD1 ANKS1B LRP4 TSHZ1 SLITRK6 PLS3	4.79e-05	200	144	6	a9ff3210127000b3dd9e97136163c98c2b0817d7
Drug	magnesium	TNPO1 GPHN FMO2 POLA1 DDX52 NARS1 DGKG CPS1 TRUB1 ERN2 GFM2 MYO5C LIG4 DNAH17 BUB1 EIF5B PRKCA PRKCB PRKCG MERTK IL36G PLS3 RAC1 RAC3	1.75e-06	1325	140	24	CID000000888
Drug	Fim 1	MECOM PRKCA PRKCB PRKCG MYB	3.04e-06	37	140	5	CID000132906
Drug	3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Down 200; 13.8uM; MCF7; HT_HG-U133A	ACACB TTLL5 MARCHF6 PRR5 ERN2 KITLG NF2 PRKCA RAC3	3.74e-06	197	140	9	6060_DN
Drug	debromoaplysiatoxin	SLC25A21 PRKCA PRKCB PRKCG	7.56e-06	21	140	4	CID000002967
Drug	myricitrin	LIG4 PRKCA PRKCB PRKCG AKR1B1	8.20e-06	45	140	5	CID005281673
Drug	1,2-dicaprin	SLC25A21 DGKG PRKCA PRKCB PRKCG	1.26e-05	49	140	5	CID000001321
Drug	thiamylal	NF2 CNTNAP2 PRKCA PRKCB PRKCG	1.26e-05	49	140	5	CID003032285
Drug	C-1A	DGKG KY PRKCA PRKCB PRKCG SPAG17	2.11e-05	91	140	6	CID009543473
Drug	C15720	SLC25A21 PRKCA PRKCB PRKCG	2.15e-05	27	140	4	CID000003979
Drug	ilmofosine	PRKCA PRKCB PRKCG RAC1	2.15e-05	27	140	4	CID000055008
Drug	aplysiatoxin	SLC25A21 PRKCA PRKCB PRKCG	2.50e-05	28	140	4	CID000040465
Drug	Atractyloside potassium salt [102130-43-8]; Down 200; 5uM; PC3; HT_HG-U133A	ISYNA1 ACACB VWA8 DDX52 ERN2 LIG4 NF2 BUB1	2.85e-05	195	140	8	7393_DN
Drug	Cefotaxime sodium salt [64485-93-4]; Down 200; 8.4uM; PC3; HT_HG-U133A	GPHN EPHX2 ISYNA1 DDX52 LIG4 NF2 NFATC3 BUB1	3.07e-05	197	140	8	2072_DN
Drug	(+)-Isoproterenol (+)-bitartrate salt [14638-70-1]; Up 200; 11uM; MCF7; HT_HG-U133A	SPTLC3 ACACB NIPSNAP3B CPS1 ERN2 STAT4 BUB1 PRKCA	3.18e-05	198	140	8	3384_UP
Drug	(S)-(-)-Atenolol [93379-54-5]; Up 200; 15uM; HL60; HT_HG-U133A	ACACB TTLL5 ERN2 TDRD1 NF2 ACSBG1 DNAH17 CNTNAP2	3.18e-05	198	140	8	3067_UP
Drug	Gf 109	HDAC5 PRKCA PRKCB PRKCG	3.31e-05	30	140	4	CID000196144
Drug	12-hydroxydaphnetoxin	PRKCA PRKCB	3.75e-05	2	140	2	CID000099841
Drug	N,n,n-tms	PRKCA PRKCB PRKCG IL36G	3.79e-05	31	140	4	CID006439410
Drug	Vanadates	SPTLC3 SLC25A21 ISYNA1 NIPSNAP3B LMCD1 DDX52 RBMS2 VXN NCKAP5 E2F5 PARP14 DYSF GFM2 MYO5C GSTM1 KITLG OSBPL6 PRKCA SLITRK6 MERTK TOP2A	4.71e-05	1302	140	21	ctd:D014638
Drug	bryostatin 1	PRKCA PRKCB PRKCG	4.81e-05	12	140	3	ctd:C046785
Drug	3'-deoxyguanosine	POLA1 GFM2 EIF5B AKR1B1	5.50e-05	34	140	4	CID000165138
Drug	4-O-methyl-TPA	SLC25A21 PRKCA PRKCB PRKCG	5.50e-05	34	140	4	CID000072292
Drug	C22:0	HDAC5 HADHB CKAP2	6.22e-05	13	140	3	CID000008215
Drug	R59949	DGKG CTNNBIP1 PRKCA PRKCB PRKCG	7.18e-05	70	140	5	CID000657356
Drug	HOE 694	GPHN PRKCA PRKCB PRKCG	7.73e-05	37	140	4	CID000123840
Drug	iso-H7	SLC25A21 PRKCA PRKCB PRKCG	7.73e-05	37	140	4	CID000001352
Drug	euxanthone	E2F5 PRKCA PRKCG	7.88e-05	14	140	3	CID005281631
Disease	systemic scleroderma (is_implicated_in)	STAT4 HNRNPL GSTM1 LTA	4.27e-06	24	136	4	DOID:418 (is_implicated_in)
Disease	glutamine measurement, amino acid measurement	TNPO1 RBMS2 CPS1	1.54e-05	11	136	3	EFO_0005134, EFO_0009768
Disease	alcohol use disorder (implicated_via_orthology)	SHMT2 PRKCA PRKCB ALYREF PRKCG RAC1 RAC3	3.52e-05	195	136	7	DOID:1574 (implicated_via_orthology)
Disease	high grade glioma (is_implicated_in)	GSTM1 LIG4 PRKCA LTA	4.22e-05	42	136	4	DOID:3070 (is_implicated_in)
Disease	autosomal dominant intellectual developmental disorder 48 (implicated_via_orthology)	RAC1 RAC3	6.31e-05	3	136	2	DOID:0080235 (implicated_via_orthology)
Disease	erythema nodosum (is_implicated_in)	GSTM1 LTA	2.09e-04	5	136	2	DOID:0080750 (is_implicated_in)
Disease	histidine measurement	TNPO1 RBMS2 CPS1 KNG1	2.49e-04	66	136	4	EFO_0009769
Disease	colorectal cancer (is_implicated_in)	GSTM1 LIG4 NF2 BUB1 RAC1	2.50e-04	121	136	5	DOID:9256 (is_implicated_in)
Disease	mean platelet volume	TNPO1 HDAC5 IQGAP2 NUP210L POLA1 MECOM CPS1 GSTM1 STAC2 BRD8 TTC13 HADHB PLS3 MYB	2.71e-04	1020	136	14	EFO_0004584
Disease	X-24747 measurement	EPHX2 ACOT4	5.80e-04	8	136	2	EFO_0022135
Disease	male homosexuality	ZNF536 SLITRK6	5.80e-04	8	136	2	EFO_0008486
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	ZNF536 FPGT GSTM1 NF2 MERTK	6.30e-04	148	136	5	C0279702
Disease	ceramide measurement	SPTLC3 TTLL5 CPS1 ERN2 STAC2 CNTNAP2	7.95e-04	235	136	6	EFO_0010222
Disease	psoriatic arthritis (is_implicated_in)	STAT4 LTA	1.13e-03	11	136	2	DOID:9008 (is_implicated_in)
Disease	Congenital myopathy (disorder)	NEB KY	1.35e-03	12	136	2	C0270960
Disease	R-6-hydroxywarfarin to R-warfarin ratio measurement	SASH1 PARP14 ACSBG1 DNAH17	1.49e-03	106	136	4	EFO_0803333
Disease	hepatocellular carcinoma (is_implicated_in)	SPAG9 STAT4 HNRNPL GSTM1 NF2	1.55e-03	181	136	5	DOID:684 (is_implicated_in)
Disease	aplastic anemia (is_implicated_in)	NBN GSTM1	1.59e-03	13	136	2	DOID:12449 (is_implicated_in)
Disease	prostate carcinoma (is_implicated_in)	E2F5 PRKCA	1.59e-03	13	136	2	DOID:10286 (is_implicated_in)
Disease	diabetic retinopathy (is_implicated_in)	GSTM1 LTA AKR1B1	1.60e-03	50	136	3	DOID:8947 (is_implicated_in)
Disease	leukemia	GSTM1 LIG4 TOP2A	2.11e-03	55	136	3	C0023418
Disease	phenylalanine measurement	RBMS2 CPS1 KNG1	2.11e-03	55	136	3	EFO_0005001
Disease	allergic disease (is_implicated_in)	GSTM1 LTA	2.13e-03	15	136	2	DOID:1205 (is_implicated_in)
Disease	factor XI measurement, fibrinogen measurement, tissue plasminogen activator measurement, factor VII measurement	CPS1 SPPL2A KNG1	2.22e-03	56	136	3	EFO_0004619, EFO_0004623, EFO_0004694, EFO_0004791
Disease	white matter microstructure measurement	NYAP2 SASH1 MECOM NCKAP5 DYSF FRMD4B SLC4A9	2.27e-03	390	136	7	EFO_0005674
Disease	triacylglycerol 48:1 measurement	NYAP2 SPAG9	2.74e-03	17	136	2	EFO_0010404
Disease	Sarcomatoid Renal Cell Carcinoma	ZNF536 FPGT GSTM1 NF2	2.96e-03	128	136	4	C1266043
Disease	Chromophobe Renal Cell Carcinoma	ZNF536 FPGT GSTM1 NF2	2.96e-03	128	136	4	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	ZNF536 FPGT GSTM1 NF2	2.96e-03	128	136	4	C1266044
Disease	Papillary Renal Cell Carcinoma	ZNF536 FPGT GSTM1 NF2	2.96e-03	128	136	4	C1306837
Disease	Renal Cell Carcinoma	ZNF536 FPGT GSTM1 NF2	2.96e-03	128	136	4	C0007134
Disease	Sjogren's syndrome (is_implicated_in)	STAT4 LTA	3.07e-03	18	136	2	DOID:12894 (is_implicated_in)
Disease	cortical surface area change measurement, age at assessment	ZNF536 SPAG9	3.43e-03	19	136	2	EFO_0008007, EFO_0021503
Disease	Systemic Scleroderma	HDAC5 STAT4	3.43e-03	19	136	2	C0036421
Disease	sensorineural hearing loss (implicated_via_orthology)	DNAH17 SLITRK6	3.43e-03	19	136	2	DOID:10003 (implicated_via_orthology)
Disease	t-tau:beta-amyloid 1-42 ratio measurement	DYTN MINDY3 NCEH1	3.55e-03	66	136	3	EFO_0007708
Disease	venous thromboembolism, fibrinogen measurement	CPS1 SPPL2A LRP4	3.70e-03	67	136	3	EFO_0004286, EFO_0004623
Disease	glycine measurement	TNPO1 NYAP2 VWA8 CPS1	3.78e-03	137	136	4	EFO_0009767
Disease	citrulline measurement	MECOM CPS1	3.79e-03	20	136	2	EFO_0009777
Disease	Prostate cancer, familial	MECOM NBN TSHZ1	4.02e-03	69	136	3	C2931456
Disease	metabolite measurement	EPHX2 FMO2 VXN SHMT2 ACOT4 CPS1 ACSM6 KNG1	4.53e-03	560	136	8	EFO_0004725
Disease	colorectal carcinoma (is_implicated_in)	GSTM1 RAC1	4.59e-03	22	136	2	DOID:0080199 (is_implicated_in)
Disease	gamma-glutamylglutamine measurement	TNPO1 RBMS2	4.59e-03	22	136	2	EFO_0021138
Disease	otitis media (implicated_via_orthology)	MECOM NF2	4.59e-03	22	136	2	DOID:10754 (implicated_via_orthology)
Disease	Leber Congenital Amaurosis	RPGRIP1 MERTK	4.59e-03	22	136	2	C0339527

Protein segments in the cluster

Peptide	Gene	Start	Entry
YALPKGMPENQEKLC	TDRD1	956	Q9BXT4
GQPNFLAPSMKLVKL	nan	571	A8MVM7
KLIQVAPPKQTYMRT	ACSM6	201	Q6P461
KKLCQMILIYEPENP	ERICH2	86	A1L162
IPILMQLKQPANKGF	DDX52	221	Q9Y2R4
KMLNLTHTYPIQKPG	SLC4A9	546	Q96Q91
YKNTPEKVMPQGLVI	BUB1	881	O43683
QAPGYKDVVKRPMDL	BRD8	1136	Q9H0E9
TGNKKQPVIVPMYAA	AFTPH	741	Q6ULP2
DPNYANKVSIPVPKM	FBXW10	341	Q5XX13
KSYQEGLARLPEMKP	AAR2	186	Q9Y312
DIPQNPKVGTKRYMA	ACVR1C	356	Q8NER5
KYIPKMAIRIPTSNP	ANKRD18B	971	A2A2Z9
VSVGILNIKLEMYPP	CEP76	241	Q8TAP6
NYMGRKTKVGLPPLE	HADHB	401	P55084
QVEMILNKPGLKYKP	AKR1B1	166	P15121
PGSLLAPNNVMKLKQ	ANO8	966	Q9HCE9
QDANMPKKPVLGSYR	CKAP2	166	Q8WWK9
KKPYVSLAQQMAPPS	RBMS2	21	Q15434
DKKLAPITYPQGLAM	RAC3	131	P60763
EKKLTPITYPQGLAM	RAC1	131	P63000
NPYPTKGEKIMLAII	IRX6	171	P78412
KEKVYIATQGPMPNT	PTPN7	161	P35236
ANGLLMLPPKTEQYV	GPHN	706	Q9NQX3
ESMPYKLNPKTGLID	SHMT2	191	P34897
KRVGPVAATYPMLNK	ISYNA1	516	Q9NPH2
VAATYPMLNKKGPVP	ISYNA1	521	Q9NPH2
HQQQPEKGPRYLMKL	IGLV4-69	56	A0A075B6H9
QGENKMKNLPVPVYL	SPAG9	661	O60271
LQDKKVGALPYPSMF	MECOM	681	Q03112
IDPAYKKLMEQLGEP	ACACB	2251	O00763
DPNYANKVSIPVPKM	FBXW10B	341	O95170
NLGFPMLAQESYPKK	ANKS1B	416	Q7Z6G8
YNVKNMIPVNKDPIL	SLC25A21	191	Q9BQT8
PEYINLMKNKLDPEG	MINDY3	341	Q9H8M7
VAYGVAMNKLTLPIP	MAP3K10	311	Q02779
LKMPEKYVGQNIGLS	NMRAL1	201	Q9HBL8
LTPSYQTAMKLVPLK	NRAP	461	Q86VF7
MKPPTKQQDGELVGY	MERTK	406	Q12866
PAEIQKEGPKAMLSY	LRRK1	611	Q38SD2
KLEVYPPTMGTHKLQ	KY	401	Q8NBH2
GTIRAMKYPLPLQKE	CFAP57	616	Q96MR6
YILGTQKQQGLMKLP	ERN2	91	Q76MJ5
LMQAGYPPITIRKEQ	FICD	381	Q9BVA6
MENTLLPYLPLQVKK	FSIP2	2616	Q5CZC0
LPYLPLQVKKDLIQM	FSIP2	2621	Q5CZC0
MPLPGYKVREIIQKL	PLS3	46	P13797
FPPLMNPVIYSIKTK	OR51B2	281	Q9Y5P1
PPLMNPIIYSIKTKQ	OR51G1	286	Q8NGK1
PPVMNPIIYSVKNKQ	OR51Q1	286	Q8NH59
PPMLNPIVYGVKTKQ	OR52B2	286	Q96RD2
PPMLNPIIYGIKTKQ	OR52B4	286	Q8NGK2
KPEVLQKYMVDPGRI	NCEH1	171	Q6PIU2
PKPAQPALKMQVLYE	EPS8L3	446	Q8TE67
PKEGVYELAVFQMKP	NIPSNAP3B	141	Q9BS92
IIKSVLPNFLPYNVM	MARCHF6	501	O60337
KILGYMQLRKGPNVV	MT-ND1	26	P03886
MDPNGLSDPYVKLKL	PRKCB	186	P05771
MDPNGLSDPYVKLKL	PRKCG	186	P05129
AQEIKYGPLKMLPQT	MYB	476	P10242
PVQRYKMLIPQLKES	MED29	56	Q9NX70
TKLPVLENVSYMKQP	NYAP2	361	Q9P242
EILPVGTLNVMLPKY	OSBPL6	706	Q9BZF3
IIPMLNPLIYSLQNK	OR8U9	281	P0C7N5
KYSAEMPQLPQDLKG	POLA1	456	P09884
LQYMELIPKEKQPVT	LMCD1	131	Q9NZU5
KLLEIATKPTYPPMN	NF2	471	P35240
GPDPPKNLNTKLQMY	PARP14	16	Q460N5
AKGELVMQYKIIPTP	DGKG	416	P49619
AELTGKMPKEYPLNI	FRMD4B	456	Q9Y2L6
VPLYKNGVKIMGTSP	CPS1	1066	P31327
EQKIMDLYGQPEPVK	IL36G	101	Q9NZH8
VGMVKPEPQIYKFLL	EPHX2	156	P34913
PIPEMGQNGQKKYQI	E2F5	201	Q15329
EEGIMVKQPLSIYKP	LIG4	426	P49917
PPGTKKLVYFIDDMN	DNAH17	2511	Q9UFH2
PSYQEGLKQDIPKMV	DYTN	481	A2CJ06
LLMQYPKAQGSRVPL	FAM83C	596	Q9BQN1
KVAKCLIGVNYPKPM	CRY1	456	Q16526
AVVIYKEPPPNKMAN	ACSBG1	231	Q96GR2
LNKSYDVKNPSPLLM	CCP110	541	O43303
LPSLGKPYKSLMAQE	SLC1A6	536	P48664
GPISYVVVMPKKRQA	HNRNPL	126	P14866
LEPQNKYIMKEPVLN	FMO2	271	Q99518
EKKIYPTVNCQPLGM	KNG1	361	P01042
PLGPLKVYCNMTEDK	CNTNAP2	621	Q9UHC6
MPKYLLGSVNKSVVP	HEPACAM2	76	A8MVW5
KIYILMQNLGPLPND	HORMAD1	156	Q86X24
KLLGPISQKMYAVLP	HDAC5	766	Q9UQL6
QVMPPKYNFPQKITG	FAM237B	116	A0A1B0GVD1
LIKAFMKNPYPGIDS	DUXA	116	A6NLW8
LQTIFLKYPMEKVPG	DYSF	831	O75923
KYGAKMEAPQRVIPV	C18orf63	86	Q68DL7
MGQKYLLPPKSSFLL	METTL4	251	Q8N3J2
ALPLGNPIYQMLELK	FPGT	146	O14772
QQEVKIYFPIMLTPK	NUP210L	456	Q5VU65
PGKAPKLMIYEVSNR	IGLV2-14	61	P01704
PPMVNPIIYGVKTKQ	OR52K1	286	Q8NGK4
PPMVNPIIYGVKTKQ	OR52K2	286	Q8NGK3
IIPMLNPLIYSLQNK	OR8U1	281	Q8NH10
LQGKMSLPVILEPSY	SYT14	371	Q8NB59
KGIQPLLDAVTMYLP	GFM2	336	Q969S9
VIVPPMSQKYPKADS	RPGRIP1	1101	Q96KN7
LPGTFNPMPKLKVLY	SLITRK6	451	Q9H5Y7
NPMPKLKVLYLNNNL	SLITRK6	456	Q9H5Y7
VYGMLNLTPKGKQAP	NARS1	181	O43776
MDPNGLSDPYVKLKL	PRKCA	186	P17252
PMGIYQKQNLTKIPP	NCKAP5	791	O14513
LAKMRIPNYQLSPTK	NBN	421	O60934
VLPMLQAIFYPVQGK	PRR5	126	P85299
PLYLAKLIFQMPQNK	IQGAP2	896	Q13576
LPPPMKELRVKNQYE	EIF5B	906	O60841
YLDLMPNPSLAQVKI	HAUS1	241	Q96CS2
LGMICYNPEFEKLKP	GSTM1	111	P09488
NLPKDYMITLKYVPG	KITLG	46	P21583
KNGTEDLPYAMKPID	NSDHL	156	Q15738
NVDKLGPMIQKYDEP	NAP1L3	321	Q99457
GPMIQKYDEPILKFL	NAP1L3	326	Q99457
ENASVVPLLLYMPGK	SPTLC3	456	Q9NUV7
LKVTYKPGPVAAGMQ	SPAG17	2121	Q6Q759
GGYKNPSMIPIEKAQ	ACOT4	301	Q8N9L9
PLVPGMEVSFYKILQ	CIP2A	491	Q8TCG1
APGKSPEEMYIQQKV	CTNNBIP1	6	Q9NSA3
MGPVSLLPKYQKLNT	CLVS1	1	Q8IUQ0
EDGLPEKLAQKNPMY	SFPQ	456	P23246
KPMTNYQIPQTALLK	VPS52	251	Q8N1B4
VPLLSSQKMVYPGLQ	LTA	146	P01374
LELNKNQPIAMLYKG	TTC13	276	Q8NBP0
NLVSMGLYTPKPQVI	ZNF383	41	Q8NA42
KVIMAENIPENPLKY	STAT4	646	Q14765
QLPKATLRKDVGPMY	STAC2	281	Q6ZMT1
VLMKKGQPALLYLVP	SPPL2A	456	Q8TCT8
SPMPLYILKGHKNTV	PLAA	101	Q9Y263
VKLLGYNEKPINLQM	NFATC3	466	Q12968
YPTLPLMKSGDALKQ	SASH1	766	O94885
QVSLKFKLLDPPNMG	TGM5	506	O43548
PKLIPVLVNGMKYSD	TNPO1	306	Q92973
LEYNLQGPGNMKEKP	ZNF536	616	O15090
LPMLPSYKNFKGTIE	TOP2A	886	P11388
LKKMTEEYPALPQGA	VXN	151	Q8TAG6
IDVNGPKAQLMLRYP	UBXN7	406	O94888
LQKFTGNIMQVPPLY	TRUB1	186	Q8WWH5
GNIMQVPPLYSALKK	TRUB1	191	Q8WWH5
PKDPTNGQMYQKTLL	UBE4A	316	Q14139
DGYNIGLVPMNKIPK	VWA8	1766	A3KMH1
MLDKPVYPATPVKQA	TSHZ1	781	Q6ZSZ6
PKYPVITQPAEMNVK	TTLL5	566	Q6EMB2
KAMKQYNGVPLDGRP	ALYREF	161	Q86V81
QLTNMDPPRKIPKGY	MORN5	106	Q5VZ52
VKIEAIPKPAMYNQL	LRP4	1776	O75096
SGIILVAMNPYKQLP	MYO5C	101	Q9NQX4
EKGKSNYSIMLEPPE	NEB	5696	P20929