Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunction[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity

HS3ST3B1 HS3ST3A1

5.90e-062492GO:0033872
GeneOntologyMolecularFunctionalkaline phosphatase activity

CILP2 CILP

8.79e-056492GO:0004035
GeneOntologyMolecularFunction[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity

HS3ST3B1 HS3ST3A1

1.23e-047492GO:0008467
GeneOntologyMolecularFunctiondinucleotide phosphatase activity

CILP2 CILP

2.10e-049492GO:0004551
GeneOntologyMolecularFunctionhormone activity

LHB CGB1 CGB3 CGB7

3.34e-04135494GO:0005179
GeneOntologyMolecularFunctionheparan sulfate sulfotransferase activity

HS3ST3B1 HS3ST3A1

6.07e-0415492GO:0034483
GeneOntologyBiologicalProcessluteinizing hormone signaling pathway involved in ovarian follicle development

LHB CGB1 CGB7

1.18e-075483GO:0035471
GeneOntologyBiologicalProcessluteinizing hormone signaling pathway

LHB CGB1 CGB7

4.11e-077483GO:0042700
GeneOntologyBiologicalProcessglossopharyngeal nerve morphogenesis

HOXB3 HOXD3

3.17e-054482GO:0021615
GeneOntologyBiologicalProcessglossopharyngeal nerve development

HOXB3 HOXD3

5.28e-055482GO:0021563
GeneOntologyBiologicalProcesscranial nerve morphogenesis

SEMA3A HOXB3 HOXD3

5.59e-0532483GO:0021602
GeneOntologyBiologicalProcessnerve development

SEMA3A HOXB3 HOXD3 LARGE1

1.20e-04109484GO:0021675
GeneOntologyBiologicalProcesspositive regulation of translation in response to stress

EIF2AK4 DDX3X

1.47e-048482GO:0032056
GeneOntologyBiologicalProcesspositive regulation of synaptic transmission

SLC8A3 NALCN EIF2AK4 BAIAP3 LARGE1

2.03e-04233485GO:0050806
GeneOntologyBiologicalProcessnegative regulation of transcription by RNA polymerase I

ACTR6 CREBBP

2.88e-0411482GO:0016479
GeneOntologyCellularComponentpituitary gonadotropin complex

LHB CGB1 CGB3 CGB7

1.85e-098494GO:0061696
MousePhenosmall vulva

LHB CGB1 CGB7

2.86e-076353MP:0003527
MousePhenosmall bulbourethral gland

LHB CGB1 CGB7

5.00e-077353MP:0013737
MousePhenosmall external male genitalia

LHB CGB1 CGB7

7.98e-078353MP:0009202
MousePhenoabnormal bulbourethral gland morphology

LHB CGB1 CGB7

3.11e-0612353MP:0001169
MousePhenothin endometrium

LHB CGB1 CGB7

6.41e-0615353MP:0008258
MousePhenoabnormal Leydig cell differentiation

LHB CGB1 CGB7

7.87e-0616353MP:0013602
MousePhenosmall prostate gland

LHB CGB1 CGB7

1.36e-0519353MP:0002774
MousePhenoabnormal external female genitalia morphology

LHB CGB1 CGB7

1.85e-0521353MP:0003126
MousePhenoabnormal sex gland secretion

LHB CGB1 CGB7

2.46e-0523353MP:0002779
MousePhenouterus hypoplasia

LHB CGB1 CGB7

2.46e-0523353MP:0001121
MousePhenodecreased Leydig cell number

LHB CGB1 CGB7

5.02e-0529353MP:0005536
MousePhenodecreased circulating progesterone level

LHB CGB1 CGB7

9.70e-0536353MP:0005185
MousePhenodecreased circulating estradiol level

LHB CGB1 CGB7

1.14e-0438353MP:0005181
MousePhenoabsent mature ovarian follicles

LHB CGB1 CGB7

1.33e-0440353MP:0001132
MousePhenodecreased circulating estrogen level

LHB CGB1 CGB7

1.44e-0441353MP:0003371
MousePhenoabnormal prostate gland size

LHB CGB1 CGB7

1.54e-0442353MP:0004959
MousePhenocervical vertebral fusion

SEMA3A HOXB3 HOXD3

1.54e-0442353MP:0004620
MousePhenoabsent estrous cycle

LHB CGB1 CGB7

1.77e-0444353MP:0009009
MousePhenoovary cyst

LHB CGB1 CGB7

2.03e-0446353MP:0002016
MousePhenoabnormal endometrium morphology

LHB CGB1 CGB7

2.45e-0449353MP:0004896
MousePhenoabnormal circulating progesterone level

LHB CGB1 CGB7

2.60e-0450353MP:0005184
MousePhenofusion of atlas and odontoid process

HOXB3 HOXD3

2.71e-0410352MP:0010701
MousePhenoabnormal circulating estradiol level

LHB CGB1 CGB7

2.92e-0452353MP:0005183
MousePhenoabnormal external male genitalia morphology

LHB CGB1 CGB7

3.09e-0453353MP:0009199
MousePhenoabnormal progesterone level

LHB CGB1 CGB7

3.27e-0454353MP:0011384
MousePhenoabnormal circulating estrogen level

LHB CGB1 CGB7

3.83e-0457353MP:0003369
MousePhenoabnormal tertiary ovarian follicle morphology

LHB CGB1 CGB7

3.83e-0457353MP:0009363
MousePhenodecreased circulating testosterone level

LHB CGB1 CGB7

4.46e-0460353MP:0002780
MousePhenoabsent corpus luteum

LHB CGB1 CGB7

5.91e-0466353MP:0001134
MousePhenosmall epididymis

LHB CGB1 CGB7

7.02e-0470353MP:0004930
MousePhenosplit xiphoid process

SEMA3A CREBBP

7.15e-0416352MP:0004678
MousePhenoabnormal uterus size

LHB CGB1 FAT3 CGB7

7.88e-04168354MP:0004902
MousePhenoabnormal prostate gland morphology

LHB CGB1 CGB7

7.93e-0473353MP:0001158
MousePhenodecreased mature ovarian follicle number

LHB CGB1 CGB7

7.93e-0473353MP:0002682
MousePhenodecreased effector memory T-helper cell number

HCAR1 CARD11

9.09e-0418352MP:0013771
MousePhenoabnormal odontoid process morphology

HOXB3 HOXD3

9.09e-0418352MP:0004659
MousePhenoabnormal mature ovarian follicle morphology

LHB CGB1 CGB7

9.62e-0478353MP:0009364
MousePhenoabnormal Leydig cell morphology

LHB CGB1 CGB7

1.11e-0382353MP:0002786
MousePhenoabnormal oogenesis

LHB CGB1 CGB7 SGO2

1.15e-03186354MP:0001931
MousePhenoabnormal circulating testosterone level

LHB CGB1 CGB7

1.19e-0384353MP:0005180
MousePhenoabnormal circulating androgen level

LHB CGB1 CGB7

1.19e-0384353MP:0009819
MousePhenoabnormal testis interstitial tissue morphology

LHB CGB1 CGB7

1.28e-0386353MP:0011416
MousePhenoabnormal testosterone level

LHB CGB1 CGB7

1.55e-0392353MP:0011385
MousePhenosmall uterus

LHB CGB1 CGB7

1.55e-0392353MP:0002637
MousePhenodecreased oocyte number

LHB CGB1 CGB7

1.70e-0395353MP:0005431
MousePhenoabnormal oocyte number

LHB CGB1 CGB7

1.75e-0396353MP:0020152
MousePhenoabnormal spermatid morphology

LHB CGB1 CGB7 SGO2

2.03e-03217354MP:0006380
DomainGonadotropin_bsu_CS

LHB CGB1 CGB3 CGB7

5.74e-106484IPR018245
DomainGonadotropin_bsu

LHB CGB1 CGB3 CGB7

1.34e-097484IPR001545
DomainGLYCO_HORMONE_BETA_2

LHB CGB1 CGB3 CGB7

1.34e-097484PS00689
DomainGHB

LHB CGB1 CGB3 CGB7

1.34e-097484SM00068
DomainGLYCO_HORMONE_BETA_1

LHB CGB1 CGB3 CGB7

1.34e-097484PS00261
DomainGlyco_hormone_CN

LHB CGB1 CGB3 CGB7

5.13e-0815484IPR006208
DomainCys_knot

LHB CGB1 CGB3 CGB7

5.13e-0815484PF00007
DomainDUF4074

HOXB3 HOXD3

1.94e-053482IPR025281
DomainDUF4074

HOXB3 HOXD3

1.94e-053482PF13293
Domain-

LHB CGB1 CGB3 CGB7

2.61e-05674842.10.90.10
DomainCystine-knot_cytokine

LHB CGB1 CGB3 CGB7

2.61e-0567484IPR029034
DomainWxxW_domain

CILP2 CILP

9.64e-056482IPR025155
DomainMucin2_WxxW

CILP2 CILP

9.64e-056482PF13330
DomainChannel_four-helix_dom

NALCN KCND3 KCNS1

4.23e-0457483IPR027359
Domain-

NALCN KCND3 KCNS1

4.23e-04574831.20.120.350
DomainCarboxyPept-like_regulatory

CILP2 CILP

8.58e-0417482IPR008969
DomainHomeobox_Antennapedia_CS

HOXB3 HOXD3

1.32e-0321482IPR001827
DomainIg_I-set

CILP2 IGFN1 LINGO1 CILP

1.42e-03190484IPR013098
DomainI-set

CILP2 IGFN1 LINGO1 CILP

1.42e-03190484PF07679
DomainANTENNAPEDIA

HOXB3 HOXD3

1.72e-0324482PS00032
DomainK_chnl_volt-dep_Kv

KCND3 KCNS1

2.18e-0327482IPR003968
DomainIGc2

CILP2 IGFN1 LINGO1 CILP

3.08e-03235484SM00408
DomainIg_sub2

CILP2 IGFN1 LINGO1 CILP

3.08e-03235484IPR003598
DomainIon_trans_dom

NALCN KCND3 KCNS1

3.14e-03114483IPR005821
DomainIon_trans

NALCN KCND3 KCNS1

3.14e-03114483PF00520
DomainVG_K_chnl

KCND3 KCNS1

3.25e-0333482IPR028325
DomainSulfotransferase_dom

HS3ST3B1 HS3ST3A1

3.85e-0336482IPR000863
DomainSulfotransfer_1

HS3ST3B1 HS3ST3A1

3.85e-0336482PF00685
DomainIG

SEMA3A CILP2 IGFN1 LINGO1 CILP

4.39e-03421485SM00409
DomainIg_sub

SEMA3A CILP2 IGFN1 LINGO1 CILP

4.39e-03421485IPR003599
PathwayREACTOME_MINERALOCORTICOID_BIOSYNTHESIS

LHB CGB1 CGB7

3.60e-0612373MM14749
PathwayREACTOME_GLYCOPROTEIN_HORMONES

LHB CGB1 CGB7

4.68e-0613373MM14830
PathwayREACTOME_REACTIONS_SPECIFIC_TO_THE_COMPLEX_N_GLYCAN_SYNTHESIS_PATHWAY

LHB CGB1 CGB7

4.68e-0613373MM15701
PathwayREACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS

LHB CGB1 CGB7

7.41e-0615373MM14832
PathwayREACTOME_HORMONE_LIGAND_BINDING_RECEPTORS

LHB CGB1 CGB7

7.41e-0615373MM14972
PathwayREACTOME_ANDROGEN_BIOSYNTHESIS

LHB CGB1 CGB7

7.41e-0615373MM14739
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_THE_AP_2_TFAP2_FAMILY_OF_TRANSCRIPTION_FACTORS

LHB CGB1 CGB7

4.15e-0526373MM15502
PathwayREACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI

LHB CGB1 CGB7

5.80e-0529373MM15699
PathwayREACTOME_METABOLISM_OF_STEROID_HORMONES

LHB CGB1 CGB7

1.66e-0441373MM14757
PathwayREACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS

LHB CGB3

5.98e-0414372M756
PathwayKEGG_MEDICUS_REFERENCE_LHCGR_GNAS_PKA_SIGNALING_PATHWAY

LHB ADCY9

7.86e-0416372M47645
PathwayREACTOME_PEPTIDE_HORMONE_METABOLISM

LHB CGB1 CGB7

8.07e-0470373MM14916
Pubmed

CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice.

LHB CGB1 CGB7 CREBBP

5.20e-11649422508984
Pubmed

Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone.

LHB CGB1 CGB3 CGB7

1.21e-1074946690982
Pubmed

Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection.

LHB CGB3 CGB7

2.63e-09349311861891
Pubmed

Luteinizing hormone induction of ovarian tumors: oligogenic differences between mouse strains dictates tumor disposition.

LHB CGB1 CGB7

2.62e-08549310618427
Pubmed

Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin beta-subunit genes.

LHB CGB3 CGB7

2.62e-0854932424697
Pubmed

Androgen-responsive microRNAs in mouse Sertoli cells.

LHB CGB1 CGB7

2.62e-08549322911753
Pubmed

Cloning of the mouse gonadotropin beta-subunit-encoding genes, II. Structure of the luteinizing hormone beta-subunit-encoding genes.

LHB CGB1 CGB7

2.62e-0854938543188
Pubmed

Isolation and characterization of the human chorionic gonadotropin beta subunit (CG beta) gene cluster: regulation of transcriptionally active CG beta gene by cyclic AMP.

CGB1 CGB3 CGB7

2.62e-0854932468994
Pubmed

Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone.

LHB CGB1 CGB7

2.62e-0854931727547
Pubmed

Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors.

LHB CGB1 CGB7

2.62e-0854937877975
Pubmed

Luteinizing hormone beta promoter stimulation by adenylyl cyclase and cooperation with gonadotropin-releasing hormone 1 in transgenic mice and LBetaT2 Cells.

LHB CGB1 CGB7

2.62e-08549317699734
Pubmed

The pleiotropic effects of excessive luteinizing hormone secretion in transgenic mice.

LHB CGB1 CGB7

2.62e-08549317710732
Pubmed

Targeted disruption of luteinizing hormone beta-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility.

LHB CGB1 CGB7

2.62e-08549315569941
Pubmed

Sulfation of LH does not affect intracellular trafficking.

LHB CGB1 CGB7

2.62e-08549319647136
Pubmed

Expression of the beta subunit of chorionic gonadotropin in transgenic mice.

LHB CGB1 CGB7

2.62e-0854937508931
Pubmed

Elevated luteinizing hormone in prepubertal transgenic mice causes hyperandrogenemia, precocious puberty, and substantial ovarian pathology.

LHB CGB1 CGB7

2.62e-0854939231809
Pubmed

Targeted overexpression of luteinizing hormone causes ovary-dependent functional adenomas restricted to cells of the Pit-1 lineage.

LHB CGB1 CGB7

2.62e-08549312960102
Pubmed

Ovulatory surges of human CG prevent hormone-induced granulosa cell tumor formation leading to the identification of tumor-associated changes in the transcriptome.

LHB CGB1 CGB7

2.62e-08549312040011
Pubmed

An Otx-related homeodomain protein binds an LHbeta promoter element important for activation during gonadotrope maturation.

LHB CGB1 CGB7

2.62e-08549312040015
Pubmed

Transgenic mice with chronically elevated luteinizing hormone are infertile due to anovulation, defects in uterine receptivity, and midgestation pregnancy failure.

LHB CGB1 CGB7

2.62e-08549310342846
Pubmed

Stress levels of glucocorticoids inhibit LHβ-subunit gene expression in gonadotrope cells.

LHB CGB1 CGB7

2.62e-08549322851703
Pubmed

The role of luteinizing hormone-beta gene polymorphism in the onset and progression of puberty in healthy boys.

LHB CGB1 CGB7

2.62e-0854938784083
Pubmed

An i-motif-regulated enhancer, eRNA and adjacent lncRNA affect Lhb expression through distinct mechanisms in a sex-specific context.

LHB CGB1 CGB7

2.62e-08549339158745
Pubmed

Effect of Soluble Adenylyl Cyclase (ADCY10) Inhibitors on the LH-Stimulated cAMP Synthesis in Mltc-1 Leydig Cell Line.

LHB CGB1 CGB7

5.24e-08649333924969
Pubmed

The beta subunit of human chorionic gonadotropin is encoded by multiple genes.

CGB1 CGB3 CGB7

5.24e-0864936194155
Pubmed

Development of a methodology for and assessment of pulsatile luteinizing hormone secretion in juvenile and adult male mice.

LHB CGB1 CGB7

5.24e-08649324092638
Pubmed

Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition.

LHB CGB1 CGB7

5.24e-08649314871891
Pubmed

Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo.

CGB1 CGB3 CGB7

5.24e-0864931371113
Pubmed

AMP-activated protein kinase is a key intermediary in GnRH-stimulated LHβ gene transcription.

LHB CGB1 CGB7

5.24e-08649323518923
Pubmed

Free fatty acids induce Lhb mRNA but suppress Fshb mRNA in pituitary LβT2 gonadotropes and diet-induced obesity reduces FSH levels in male mice and disrupts the proestrous LH/FSH surge in female mice.

LHB CGB1 CGB7

5.24e-08649323525221
Pubmed

Maximal activity of the luteinizing hormone beta-subunit gene requires beta-catenin.

LHB CGB1 CGB7

5.24e-08649317244763
Pubmed

The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of luteinizing hormone.

CGB1 CGB3 CGB7

5.24e-0864936319099
Pubmed

The role of amino acid neurotransmitters in the regulation of pituitary gonadotropin release in fish.

LHB CGB1 CGB7

5.24e-08649310949077
Pubmed

Secretoneurin stimulates the production and release of luteinizing hormone in mouse L{beta}T2 gonadotropin cells.

LHB CGB1 CGB7

5.24e-08649321521715
Pubmed

Dependence of uterine cyclooxygenase2 expression on luteinizing hormone signaling.

LHB CGB1 CGB7

5.24e-08649315814897
Pubmed

Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice.

LHB CGB1 CGB7

5.24e-08649317569755
Pubmed

Functional analysis of LHbeta knockout mice.

LHB CGB1 CGB7

5.24e-08649317350160
Pubmed

Ablation of GalNAc-4-sulfotransferase-1 enhances reproduction by altering the carbohydrate structures of luteinizing hormone in mice.

LHB CGB1 CGB7

5.24e-08649318431515
Pubmed

The calcium component of gonadotropin-releasing hormone-stimulated luteinizing hormone subunit gene transcription is mediated by calcium/calmodulin-dependent protein kinase type II.

LHB CGB1 CGB7

5.24e-08649312746302
Pubmed

Distinct mechanisms involving diverse histone deacetylases repress expression of the two gonadotropin beta-subunit genes in immature gonadotropes, and their actions are overcome by gonadotropin-releasing hormone.

LHB CGB1 CGB7

5.24e-08649317371839
Pubmed

Differential activation of the luteinizing hormone beta-subunit promoter by activin and gonadotropin-releasing hormone: a role for the mitogen-activated protein kinase signaling pathway in LbetaT2 gonadotrophs.

LHB CGB1 CGB7

5.24e-08649313679314
Pubmed

Increases in luteinizing hormone are associated with declines in cognitive performance.

LHB CGB1 CGB7

5.24e-08649317376589
Pubmed

Luteinizing hormone promotes gonadal tumorigenesis in inhibin-deficient mice.

LHB CGB1 CGB7

5.24e-08649318657590
Pubmed

The beta chorionic gonadotropin-beta luteinizing gene cluster maps to human chromosome 19.

CGB1 CGB3 CGB7

5.24e-0864936204923
Pubmed

Different signaling pathways control acute induction versus long-term repression of LHbeta transcription by GnRH.

LHB CGB1 CGB7

5.24e-08649312193554
Pubmed

The role of endocannabinoids in the regulation of luteinizing hormone and prolactin release. Differences between the effects of AEA and 2AG.

LHB CGB1 CGB7

5.24e-08649318308464
Pubmed

A new role for wilms tumor protein 1: differential activities of + KTS and -KTS variants to regulate LHβ transcription.

LHB CGB1 CGB7

5.24e-08649325617744
Pubmed

A map of the hCG beta-LH beta gene cluster.

CGB1 CGB3 CGB7

5.24e-0864932422163
Pubmed

Development of leydig cells in the insulin-like growth factor-I (igf-I) knockout mouse: effects of igf-I replacement and gonadotropic stimulation.

LHB CGB1 CGB7

5.24e-08649314585811
Pubmed

The lack of estrogen and excess luteinizing hormone are responsible for the female ArKO mouse phenotype.

LHB CGB1 CGB7

5.24e-08649320546829
Pubmed

Early growth response protein 1 binds to the luteinizing hormone-beta promoter and mediates gonadotropin-releasing hormone-stimulated gene expression.

LHB CGB1 CGB7

9.16e-08749310319325
Pubmed

Icam5 Expression Exhibits Sex Differences in the Neonatal Pituitary and Is Regulated by Estradiol and Bisphenol A.

LHB CGB1 CGB7

9.16e-08749326789235
Pubmed

Embryonic expression of the luteinizing hormone beta gene appears to be coupled to the transient appearance of p8, a high mobility group-related transcription factor.

LHB CGB1 CGB7

9.16e-08749312429736
Pubmed

Expression of the pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1R) potentiates the effects of GnRH on gonadotropin subunit gene expression.

LHB CGB1 CGB7

9.16e-08749321658369
Pubmed

Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function in mice.

LHB CGB1 CGB7

9.16e-08749324706813
Pubmed

Disruption of the single copy gonadotropin-releasing hormone receptor in mice by gene trap: severe reduction of reproductive organs and functions in developing and adult mice.

LHB CGB1 CGB7

9.16e-08749320068010
Pubmed

Reference intervals for serum testosterone, SHBG, LH and FSH in males from the NORIP project.

LHB CGB1 CGB7

9.16e-08749319929279
Pubmed

Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice.

LHB CGB1 CGB7

9.16e-08749312748296
Pubmed

Assignment of the genes for the alpha and beta subunits of thyrotropin to different mouse chromosomes.

LHB CGB1 CGB7

9.16e-0874936582507
Pubmed

Regulation of LH/FSH expression by secretoglobin 3A2 in the mouse pituitary gland.

LHB CGB1 CGB7

9.16e-08749324514953
Pubmed

Biphasic Roles of Clock Genes and Bone Morphogenetic Proteins in Gonadotropin Expression by Mouse Gonadotrope Cells.

LHB CGB1 CGB7

9.16e-08749334681844
Pubmed

FOXO1 transcription factor inhibits luteinizing hormone β gene expression in pituitary gonadotrope cells.

LHB CGB1 CGB7

9.16e-08749322865884
Pubmed

PPARγ co-activator-1α co-activates steroidogenic factor 1 to stimulate the synthesis of luteinizing hormone and aldosterone.

LHB CGB1 CGB7

9.16e-08749321108604
Pubmed

Ovulation involves the luteinizing hormone-dependent activation of G(q/11) in granulosa cells.

LHB CGB1 CGB7

9.16e-08749323836924
Pubmed

Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2.

LHB CGB1 CGB7

9.16e-08749317299135
Pubmed

Evidence for cross-talk between the LH receptor and LH during implantation in mice.

LHB CGB1 CGB7

9.16e-08749323464498
Pubmed

The orphan nuclear receptors COUP-TFI and COUP-TFII regulate expression of the gonadotropin LHβ gene.

LHB CGB1 CGB7

9.16e-08749320797425
Pubmed

Mutual Effects of Orexin and Bone Morphogenetic Proteins on Gonadotropin Expression by Mouse Gonadotrope Cells.

LHB CGB1 CGB7

9.16e-08749336077179
Pubmed

Cyclic GMP signaling is involved in the luteinizing hormone-dependent meiotic maturation of mouse oocytes.

LHB CGB1 CGB7

9.16e-08749319474061
Pubmed

Anterior pituitary development: short tales from dwarf mice.

LHB CGB1 CGB7

9.16e-0874931505020
Pubmed

A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis.

LHB CGB1 CGB7

9.16e-0874939501026
Pubmed

Stress rapidly suppresses in vivo LH pulses and increases activation of RFRP-3 neurons in male mice.

LHB CGB1 CGB7

9.16e-08749330382693
Pubmed

Absent Progesterone Signaling in Kisspeptin Neurons Disrupts the LH Surge and Impairs Fertility in Female Mice.

LHB CGB1 CGB7

9.16e-08749326076042
Pubmed

LIM homeodomain transcription factor Isl-1 enhances follicle stimulating hormone-beta and luteinizing hormone-beta gene expression and mediates the activation of leptin on gonadotropin synthesis.

LHB CGB1 CGB7

1.46e-07849320702576
Pubmed

The polycystic ovary syndrome-associated gene Yap1 is regulated by gonadotropins and sex steroid hormones in hyperandrogenism-induced oligo-ovulation in mouse.

LHB CGB1 CGB7

1.46e-07849328961951
Pubmed

Gonadotrope-specific deletion of Dicer results in severely suppressed gonadotropins and fertility defects.

LHB CGB1 CGB7

1.46e-07849325525274
Pubmed

Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone.

LHB CGB1 CGB7

1.46e-07849326522847
Pubmed

Gonadotrope and thyrotrope development in the human and mouse anterior pituitary gland.

LHB CGB1 CGB7

1.46e-07849316806148
Pubmed

Transforming growth factor-beta1 null mutation causes infertility in male mice associated with testosterone deficiency and sexual dysfunction.

LHB CGB1 CGB7

1.46e-07849317478551
Pubmed

The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus.

LHB CGB1 CGB7

1.46e-0784937659091
Pubmed

Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism.

LHB CGB1 CGB7

2.19e-07949317959774
Pubmed

Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2.

LHB CGB1 CGB7

2.19e-07949316537498
Pubmed

Pituitary homeobox 1 (Ptx1) is differentially expressed during pituitary development.

LHB CGB1 CGB7

2.19e-07949310067870
Pubmed

Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin.

LHB CGB1 CGB7

2.19e-0794938389457
Pubmed

Hypothalamic dysregulation and infertility in mice lacking the homeodomain protein Six6.

LHB CGB1 CGB7

2.19e-07949321228153
Pubmed

Chromosome assignment of genes encoding the alpha and beta subunits of glycoprotein hormones in man and mouse.

LHB CGB1 CGB7

2.19e-0794936581542
Pubmed

The mouse cyclin E maps to chromosome 7.

LHB CGB1 CGB7

3.13e-07104938833259
Pubmed

Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2.

LHB CGB1 CGB7

3.13e-071049324739304
Pubmed

Steroidogenic Factor 1 Regulates Transcription of the Inhibin B Coreceptor in Pituitary Gonadotrope Cells.

LHB CGB1 CGB7

3.13e-071049335957608
Pubmed

Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis.

LHB CGB1 CGB7

3.13e-071049323728177
Pubmed

Location of the DBP transcription factor gene in human and mouse.

LHB CGB1 CGB7

4.30e-07114938903733
Pubmed

Candidate genes for panhypopituitarism identified by gene expression profiling.

LHB CGB1 CGB7

4.30e-071149321828248
Pubmed

Loss of the protein NUPR1 (p8) leads to delayed LHB expression, delayed ovarian maturation, and testicular development of a sertoli-cell-only syndrome-like phenotype in mice.

LHB CGB1 CGB7

4.30e-071149318495683
Pubmed

Hes1 regulates formations of the hypophyseal pars tuberalis and the hypothalamus.

LHB CGB1 CGB7

4.30e-071149320431921
Pubmed

Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans.

LHB CGB1 CGB7

4.30e-071149316932809
Pubmed

Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development.

LHB CGB1 CGB7

4.30e-071149325915183
Pubmed

Dynamics of ovarian development in the FORKO immature mouse: structural and functional implications for ovarian reserve.

LHB CGB1 CGB7

5.73e-071249312801993
Pubmed

Prenatal expression of cholecystokinin (CCK) in the central nervous system (CNS) of mouse.

LHB CGB1 CGB7

5.73e-071249318462884
Pubmed

Targeted disruption of the murine Plag1 proto-oncogene causes growth retardation and reduced fertility.

LHB CGB1 CGB7

5.73e-071249315606491
Pubmed

Msx1 homeodomain protein represses the αGSU and GnRH receptor genes during gonadotrope development.

LHB CGB1 CGB7

5.73e-071249323371388
Cytoband19q13.32

LHB CGB1 CGB3 CGB7

1.25e-067449419q13.32
Cytoband17p12

HS3ST3B1 HS3ST3A1

1.27e-034949217p12
CytobandEnsembl 112 genes in cytogenetic band chr17p12

HS3ST3B1 HS3ST3A1

2.16e-0364492chr17p12
Cytoband16p13.3

BAIAP3 CREBBP ADCY9

2.28e-0324449316p13.3
GeneFamilySulfotransferases, membrane bound

HS3ST3B1 HS3ST3A1

2.59e-0337372763
GeneFamilyPotassium voltage-gated channels

KCND3 KCNS1

3.03e-0340372274
GeneFamilyHOXL subclass homeoboxes

HOXB3 HOXD3

5.07e-0352372518
GeneFamilyImmunoglobulin like domain containing

SEMA3A CILP2 CILP

7.13e-03193373594
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-6|TCGA-Kidney / Sample_Type by Project: Shred V9

SEMA3A CILP2 CGB1 CGB7 HS3ST3A1 PIF1

1.95e-08156496d249747c7108a0edfc72d24c09b0b0e4ed662b40
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CILP2 TMEM47 LINGO1 HS3ST3B1 HS3ST3A1

2.49e-061974953fe665c0277d091290b63f0dd24c0c6536a45309
ToppCellFetal_29-31_weeks-Immune-dendritic_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SH2B3 HCAR1 CARD11 HS3ST3B1

2.24e-0515049457f21ad380fd1350a2c25d75ad8c3b763ded53ec
ToppCellCOVID-19-Heart-T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC8A3 IGFN1 TMEM132D CARD11

3.73e-05171494b2e753e811a7639956994609f73efcdb62d04f82
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Plasmacytoid_Dendritic_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SH2B3 WNT8B CARD11 HS3ST3B1

3.73e-05171494af1c93eb75f45c042ea475d93db56e4da207e31f
ToppCelldroplet-Kidney-nan-3m-Epithelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCND3 HCAR1 HS3ST3B1 HS3ST3A1

3.82e-05172494073a503dc922e3e3ac3528e249b0f8b74402110b
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA3A CILP2 LINGO1 HOXD3

4.09e-051754949d082ba0e350162aa6e71b668be074b12a27c7ab
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA3A CILP2 LINGO1 HOXD3

4.09e-05175494f641f34b52aec5d047430a6f9d026e915da6c11d
ToppCellfacs-Marrow-T_cells-18m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CARD11 HS3ST3A1 DNTT LARGE1

4.18e-0517649474f851a398c7562dd713bc0d8d488c0037243112
ToppCellfacs-Marrow-T_cells-18m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CARD11 HS3ST3A1 DNTT LARGE1

4.18e-0517649431b5459a978d5cdde0af03a77401e0464d8c95ba
ToppCellfacs-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEMA3A CILP2 LINGO1 HOXD3

4.66e-05181494cc77ac0e223e012767222e45c5dcadc246d1aa7c
ToppCellfacs-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEMA3A CILP2 LINGO1 HOXD3

4.66e-05181494b0fff0defba9aea6fba36e378b05a59986e2573a
ToppCellfacs-Lung-18m-Endothelial-lymphatic_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEMA3A CILP2 LINGO1 HOXD3

4.66e-05181494ecd52f33841f4e9d946a4edad0d58da9b0cc5ffa
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KCND3 HS3ST3B1 HS3ST3A1 LARGE1

4.86e-051834943c516fe5083f02bad1f464ed284010b4131a833c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NALCN HS3ST3B1 HS3ST3A1 LARGE1

4.86e-05183494848fc6dd129150897ee339343e83c645b6e779eb
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KCND3 HS3ST3B1 HS3ST3A1 LARGE1

4.86e-051834949c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_3|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

SEMA3A HOXB3 FAT3 HS3ST3A1

4.86e-05183494f4ea7113ce9099222743d9ff02388d3d8a9e987b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KCND3 HS3ST3B1 HS3ST3A1 LARGE1

5.07e-051854949197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KCND3 HS3ST3B1 HS3ST3A1 LARGE1

5.07e-05185494ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

HOXB3 NALCN FAT3 HS3ST3A1

5.29e-05187494bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NALCN KCND3 TMEM132D BAIAP3

5.40e-05188494c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCellPCW_10-12-Epithelial-Epithelial_neuroendo|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

NALCN KCND3 TMEM132D BAIAP3

5.63e-051904942375e604eacd38f61f3e661ba2f76d286fcceca7
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_2-SCMF|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

HOXB3 TMEM47 NALCN HS3ST3A1

5.86e-0519249467e845e513e76e820f55e2f0d15eb16f2944d05c
ToppCellParenchymal-NucSeq-Stromal-Chondrocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GPR161 CILP ANO7 HS3ST3A1

5.98e-05193494df4afb4848eb9d7d8d39e5c612919663cbbb2514
ToppCellParenchymal-NucSeq-Stromal-Chondrocytic-Chondrocyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GPR161 CILP ANO7 HS3ST3A1

5.98e-05193494ab36d684bde8fe77d11a5188425135328052c58b
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

HOXB3 TMEM47 NALCN HS3ST3A1

5.98e-051934945de87fc94a6e58899ef4124cf4887ed3ff96163a
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GPR161 LINGO1 FAT3 KCNS1

6.22e-05195494787e95fb59c40bba784544b662fac37606ae1427
ToppCellTracheal-10x3prime_v2-Stromal-Mesofibroblastic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

PIK3R4 HOXB3 FAT3 HS3ST3B1

6.47e-05197494d7cef7881abd807a679432766ced609a6efd1067
ToppCellTracheal-10x3prime_v2-Stromal-Mesofibroblastic-Mesothelia|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

PIK3R4 HOXB3 FAT3 HS3ST3B1

6.47e-0519749420a5958512bdb99daeb8f4d244df53e4f048f879
ToppCellBronchial-NucSeq-Stromal-Chondrocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CILP2 ZKSCAN1 HS3ST3B1 HS3ST3A1

6.86e-05200494b7b9441fa7ab0d43741a2ebd5ec1a48d537c6d47
ToppCellBronchial-NucSeq-Stromal-Chondrocytic-Chondrocyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CILP2 ZKSCAN1 HS3ST3B1 HS3ST3A1

6.86e-052004947c673ad0ea503ebd196579684d25d5f9e6a41030
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Slc17a6-Inhibitory_Neuron.Slc17a6-Gad1Gad2.Asb4_(Periventricular_Fiber_System_(Pv))|Thalamus / BrainAtlas - Mouse McCarroll V32

TEX36 IGFN1 ANO7

1.52e-049449382e9178c848468497295c4cc59c662b9279208a1
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Slc17a6-Inhibitory_Neuron.Slc17a6-Gad1Gad2.Asb4_(Periventricular_Fiber_System_(Pv))-|Thalamus / BrainAtlas - Mouse McCarroll V32

TEX36 IGFN1 ANO7

1.52e-0494493be1dcfe287f58d608ccdb47cf9c1d12b5e3aa60d
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Slc17a6|Thalamus / BrainAtlas - Mouse McCarroll V32

TEX36 IGFN1 ANO7

1.52e-0494493576c37fa53fab679f5e8786f5c798e18998186e9
Diseaselutropin subunit beta measurement

LHB CGB3

7.77e-063482EFO_0801773
Diseaseluteinizing hormone measurement

LHB CGB3

9.26e-059482EFO_0007002
Diseasehuman Chorionic Gonadotropin measurement

LHB CGB3

2.00e-0413482EFO_0008156
DiseaseHypogonadotropic hypogonadism

LHB CGB3

2.68e-0415482C0271623
DiseasePrimary hypogonadism

LHB CGB3

2.68e-0415482C0948896
DiseaseHypogonadism, Isolated Hypogonadotropic

LHB CGB3

2.68e-0415482C3489396
Diseasemyelodysplastic syndrome (implicated_via_orthology)

PRPF8 CREBBP

2.68e-0415482DOID:0050908 (implicated_via_orthology)
DiseaseHypogonadism

LHB CGB3

3.06e-0416482C0020619
Diseasecorneal topography

SLC8A3 EIF2AK4 HS3ST3B1

7.51e-04109483EFO_0004345
DiseaseSezary Syndrome

CARD11 CREBBP

8.86e-0427482C0036920
Diseaselate-onset Alzheimers disease

SEMA3A LINGO1 FAT3 HS3ST3B1

1.30e-03292484EFO_1001870
Diseasestroke

SEMA3A SH2B3 PRPF8

1.68e-03144483EFO_0000712
Diseasepulse pressure measurement

PIK3R4 HOXB3 CILP2 HOXD3 FAT3 EIF2AK4 ACCSL PIF1

1.68e-031392488EFO_0005763
Diseaseserum albumin measurement

CILP2 SH2B3 EIF2AK4 ADCY9 TMEM121

2.69e-03592485EFO_0004535
Diseasemotion sickness

HOXB3 HOXD3

2.79e-0348482EFO_0006928

Protein segments in the cluster

PeptideGeneStartEntry
EVARFLTYYCRAPTR

ACCSL

216

Q4AC99
FPGFRDRVYSEVRCL

ACTR6

326

Q9GZN1
PTRYIESEFCRRRRL

FAM228B

216

P0C875
RYCIERVFRPRKLDR

EIF2AK4

1136

Q9P2K8
ELFYFSVPAEACRRR

BAIAP3

1081

O94812
SIHFFRPRCLRTAVY

CREBBP

1436

Q92793
VCNYRDVRFESIRLP

CGB1

106

A6NKQ9
RLDARKFVCEYRRPV

ANO7

741

Q6IWH7
ARKFSYRSRVRPCVV

DDX3X

286

O00571
RDPEVFRCVLNFYRT

KCND3

86

Q9UK17
VVVRRDCPEYDRRFV

LARGE1

661

O95461
DREVVRRLREFYRPF

HS3ST3B1

361

Q9Y662
VCTYRDVRFESIRLP

LHB

76

P01229
VCNYRDVRFESIRLP

CGB7

76

P0DN87
RRVYSRFEPFCKIES

FAM83B

931

Q5T0W9
CYPLRRAIVFTRQLV

OR52A4P

131

A6NMU1
PNYFTCRRARIRDRK

LINGO1

416

Q96FE5
DREVVRRLREFYRPF

HS3ST3A1

376

Q9Y663
VRDDPVLRRLEYFCI

KCNS1

266

Q96KK3
KEFHFNRYLCRPRRV

HOXD3

211

P31249
VCNYRDVRFESIRLP

CGB3

76

P0DN86
RISFVCPRFYRNVRC

FAT3

3771

Q8TDW7
EFHFNRYLCRPRRVE

HOXB3

206

P14651
ERCFPQTQRRFRYAL

ADCY9

106

O60503
ARVFSRAALERYVPR

CYP26C1

146

Q6V0L0
VCYGFIFRVARVKAR

GPR161

206

Q8N6U8
ICLPFRTDYYLRRRH

HCAR1

66

Q9BXC0
RQRDRFTVKAPCYRE

IGFN1

1136

Q86VF2
IPYSLVRAFYCERRR

CARD11

961

Q9BXL7
VRAFYCERRRPVLFT

CARD11

966

Q9BXL7
ETLRLFSRVIPEYCR

ARCN1

81

P48444
PRCFPLRAARLFTRF

PIF1

66

Q9H611
VRCDPRVLHFYATLR

PIF1

601

Q9H611
PCLRVFAFRETREVR

TMEM132D

166

Q14C87
RVDLVLCPYERRAFA

DNTT

431

P04053
ERTSRRRRCTPFYFK

SGO2

1241

Q562F6
ACSRYFPTAKRRTRR

SEMA3A

541

Q14563
QIYRRRTCYARLPFL

PIGW

96

Q7Z7B1
VPESRRCFVKVRAYR

CILP

746

O75339
RCFVKVRAYRSERFL

CILP

751

O75339
VPERRRCFVKVRAYA

CILP2

731

Q8IUL8
FFDTSRRRTCYIAPE

PIK3R4

186

Q99570
RRRTCYIAPERFVDG

PIK3R4

191

Q99570
RLFCRYIDRIHIFFR

PRPF8

1086

Q6P2Q9
RRVTKYFCSRAERPR

WNT8B

326

Q93098
ACTFLEYRRQVRDFP

TMEM121

261

Q9BTD3
FQRYFCREVRDGRAP

SH2B3

71

Q9UQQ2
ISICVGSRRRFYRPV

TMEM47

101

Q9BQJ4
DPEIFRQRFRRFCYQ

ZKSCAN1

51

P17029
VVSSFRRFPRCYKEI

TEX36

136

Q5VZQ5
IFRRRFRQFCYQESP

ZSCAN23

46

Q3MJ62
IRAFRIYFRFELPRT

NALCN

151

Q8IZF0
FAFVCISVLLYRRRP

SLC8A3

871

P57103