Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR8A1 OR8K1 OR52I1 OR5M9 OR2T27 OR2AP1 OR2T35 OR6C2 OR6C4 OR6C70 OR2T7 OR6C1 OR6C75 OR6C74 OR52E1 OR6C3 OR2T1 OR2T2 OR6C65 OR5AP2 OR2AG1	2.17e-16	431	89	21	GO:0004984
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR8A1 OR8K1 OR52I1 OR5M9 OR2T27 OR2AP1 OR2T35 OR6C2 OR6C4 OR6C70 OR2T7 OR6C1 OR6C75 OR6C74 OR52E1 OR6C3 OR2T1 OR2T2 OR6C65 OR5AP2 OR2AG1	2.19e-10	884	89	21	GO:0004930
GeneOntologyMolecularFunction	intracellularly cAMP-activated cation channel activity	HCN4 HCN1 HCN3 HCN2	7.59e-08	10	89	4	GO:0005222
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR8A1 OR8K1 OR52I1 OR5M9 OR2T27 OR2AP1 OR2T35 OR6C2 OR6C4 OR6C70 OR2T7 OR6C1 OR6C75 OR6C74 OR52E1 OR6C3 OR2T1 OR2T2 OR6C65 IL2RA OR5AP2 OR2AG1	8.01e-08	1353	89	22	GO:0004888
GeneOntologyMolecularFunction	intracellularly cyclic nucleotide-activated monoatomic cation channel activity	HCN4 HCN1 HCN3 HCN2	2.56e-07	13	89	4	GO:0005221
GeneOntologyMolecularFunction	cyclic nucleotide-activated monoatomic ion channel activity	HCN4 HCN1 HCN3 HCN2	2.56e-07	13	89	4	GO:0043855
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	HCN4 HCN1 HCN3 HCN2 ITPR3	3.38e-07	33	89	5	GO:0005217
GeneOntologyMolecularFunction	cAMP binding	HCN4 HCN1 HCN3 HCN2	4.34e-06	25	89	4	GO:0030552
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	HCN4 HCN1 HCN3 HCN2	5.11e-06	26	89	4	GO:0005248
GeneOntologyMolecularFunction	cyclic nucleotide binding	HCN4 HCN1 HCN3 HCN2	2.69e-05	39	89	4	GO:0030551
GeneOntologyMolecularFunction	sodium channel activity	HCN4 HCN1 HCN3 HCN2	8.48e-05	52	89	4	GO:0005272
GeneOntologyMolecularFunction	voltage-gated potassium channel activity	HCN4 HCN1 HCN3 HCN2 KCNH5	9.31e-05	102	89	5	GO:0005249
GeneOntologyMolecularFunction	potassium channel activity	HCN4 HCN1 HCN3 HCN2 KCNH5	2.70e-04	128	89	5	GO:0005267
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	HCN4 HCN1 HCN3 HCN2 ITPR3	4.08e-04	140	89	5	GO:0099094
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	HCN4 HCN1 HCN3 HCN2 KCNH5	5.94e-04	152	89	5	GO:0022843
GeneOntologyMolecularFunction	potassium ion transmembrane transporter activity	HCN4 HCN1 HCN3 HCN2 KCNH5	9.08e-04	167	89	5	GO:0015079
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	HCN4 HCN1 HCN3 HCN2 KCNH5	1.33e-03	182	89	5	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	HCN4 HCN1 HCN3 HCN2 KCNH5	1.40e-03	184	89	5	GO:0022832
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	HCN4 HCN1 HCN3 HCN2 ITPR3	1.72e-03	193	89	5	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	HCN4 HCN1 HCN3 HCN2 ITPR3	1.89e-03	197	89	5	GO:0022834
GeneOntologyMolecularFunction	retinol binding	ADH7 RBP3	2.26e-03	16	89	2	GO:0019841
GeneOntologyMolecularFunction	odorant binding	OR8A1 OR8K1 OR5M9 OR5AP2	2.51e-03	127	89	4	GO:0005549
GeneOntologyMolecularFunction	endonuclease activity	SLFN13 NYNRIN POLQ PGBD5	3.21e-03	136	89	4	GO:0004519
GeneOntologyMolecularFunction	gated channel activity	HCN4 HCN1 HCN3 HCN2 KCNH5 ITPR3	3.80e-03	334	89	6	GO:0022836
GeneOntologyMolecularFunction	monoatomic cation channel activity	HCN4 HCN1 HCN3 HCN2 KCNH5 ITPR3	4.33e-03	343	89	6	GO:0005261
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR8A1 OR8K1 OR52I1 OR5M9 OR2T27 OR2AP1 OR2T35 OR6C2 OR6C4 OR6C70 OR2T7 OR6C1 OR6C75 OR6C74 OR52E1 OR6C3 OR2T1 OR2T2 OR6C65 OR5AP2 OR2AG1	1.54e-16	432	90	21	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR8A1 OR8K1 OR52I1 OR5M9 OR2T27 OR2AP1 OR2T35 OR6C2 OR6C4 OR6C70 OR2T7 OR6C1 OR6C75 OR6C74 OR52E1 OR6C3 OR2T1 OR2T2 OR6C65 OR5AP2 OR2AG1	6.71e-16	465	90	21	GO:0007608
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR8A1 OR8K1 OR52I1 OR5M9 OR2T27 OR2AP1 OR2T35 OR6C2 OR6C4 OR6C70 OR2T7 OR6C1 OR6C75 OR6C74 OR52E1 OR6C3 OR2T1 OR2T2 OR6C65 OR5AP2 ITPR3 OR2AG1	1.37e-15	547	90	22	GO:0007606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR8A1 OR8K1 OR52I1 OR5M9 OR2T27 OR2AP1 OR2T35 OR6C2 OR6C4 OR6C70 OR2T7 OR6C1 OR6C75 OR6C74 OR52E1 OR6C3 OR2T1 OR2T2 OR6C65 OR5AP2 OR2AG1	1.55e-15	485	90	21	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR8A1 OR8K1 OR52I1 OR5M9 OR2T27 OR2AP1 OR2T35 OR6C2 OR6C4 OR6C70 OR2T7 OR6C1 OR6C75 OR6C74 OR52E1 OR6C3 OR2T1 OR2T2 OR6C65 OR5AP2 OR2AG1	7.16e-15	524	90	21	GO:0009593
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR8A1 OR8K1 OR52I1 OR5M9 OR2T27 OR2AP1 OR2T35 OR6C2 OR6C4 OR6C70 OR2T7 OR6C1 OR6C75 OR6C74 OR52E1 OR6C3 OR2T1 OR2T2 OR6C65 OR5AP2 OR2AG1	5.60e-14	582	90	21	GO:0050906
GeneOntologyBiologicalProcess	sensory perception	OR8A1 OR8K1 OR52I1 OR5M9 HMCN1 OR2T27 OR2AP1 OR2T35 OR6C2 OR6C4 OR6C70 OR2T7 OR6C1 OR6C75 ACP3 OR6C74 RBP3 OR52E1 OR6C3 OR2T1 OR2T2 OR6C65 PKHD1L1 OR5AP2 ITPR3 OR2AG1	3.59e-13	1072	90	26	GO:0007600
GeneOntologyBiologicalProcess	detection of stimulus	OR8A1 OR8K1 OR52I1 OR5M9 OR2T27 OR2AP1 OR2T35 OR6C2 OR6C4 OR6C70 OR2T7 OR6C1 OR6C75 OR6C74 OR52E1 OR6C3 OR2T1 OR2T2 OR6C65 OR5AP2 OR2AG1	3.51e-12	722	90	21	GO:0051606
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR8A1 OR8K1 OR52I1 OR5M9 OR2T27 OR2AP1 OR2T35 OR6C2 OR6C4 OR6C70 OR2T7 OR6C1 OR6C75 ACP3 OR6C74 OR52E1 OR6C3 OR2T1 OR2T2 OR6C65 OR5AP2 ITPR3 OR2AG1	2.01e-08	1395	90	23	GO:0007186
GeneOntologyBiologicalProcess	cellular response to cAMP	HCN4 HCN1 HCN3 HCN2 ITPR3	3.44e-06	53	90	5	GO:0071320
GeneOntologyBiologicalProcess	response to cAMP	HCN4 HCN1 HCN3 HCN2 ITPR3	6.64e-05	97	90	5	GO:0051591
GeneOntologyBiologicalProcess	regulation of membrane depolarization	HCN4 HCN1 HCN3 HCN2	1.46e-04	61	90	4	GO:0003254
GeneOntologyBiologicalProcess	cellular response to cGMP	HCN4 HCN2	3.90e-04	7	90	2	GO:0071321
GeneOntologyBiologicalProcess	response to organophosphorus	HCN4 HCN1 HCN3 HCN2 ITPR3	3.96e-04	142	90	5	GO:0046683
GeneOntologyCellularComponent	HCN channel complex	HCN4 HCN1 HCN3 HCN2	3.21e-10	4	90	4	GO:0098855
GeneOntologyCellularComponent	voltage-gated potassium channel complex	HCN4 HCN1 HCN3 HCN2 KCNH5	4.59e-05	91	90	5	GO:0008076
GeneOntologyCellularComponent	potassium channel complex	HCN4 HCN1 HCN3 HCN2 KCNH5	8.69e-05	104	90	5	GO:0034705
GeneOntologyCellularComponent	cation channel complex	HCN4 HCN1 HCN3 HCN2 SLCO6A1 KCNH5	5.37e-04	235	90	6	GO:0034703
HumanPheno	Subcortical band heterotopia	FAT4 LAMB1 TUBGCP2	2.15e-05	10	30	3	HP:0032409
HumanPheno	Subcortical heterotopia	FAT4 LAMB1 TUBGCP2	3.91e-05	12	30	3	HP:0032391
Domain	Olfact_rcpt	OR8A1 OR8K1 OR52I1 OR5M9 OR2T27 OR2AP1 OR2T35 OR6C2 OR6C4 OR6C70 OR6C1 OR6C75 OR6C74 OR6C3 OR2T1 OR2T2 OR6C65 OR5AP2 OR2AG1	2.11e-14	393	88	19	IPR000725
Domain	GPCR_Rhodpsn_7TM	OR8A1 OR8K1 OR52I1 OR5M9 OR2T27 OR2AP1 OR2T35 OR6C2 OR6C4 OR6C70 OR6C1 OR6C75 OR6C74 OR6C3 OR2T1 OR2T2 OR6C65 OR5AP2 OR2AG1	2.37e-10	670	88	19	IPR017452
Domain	7tm_1	OR8A1 OR8K1 OR52I1 OR5M9 OR2T27 OR2AP1 OR2T35 OR6C2 OR6C4 OR6C70 OR6C1 OR6C75 OR6C74 OR6C3 OR2T1 OR2T2 OR6C65 OR5AP2 OR2AG1	2.82e-10	677	88	19	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR8A1 OR8K1 OR52I1 OR5M9 OR2T27 OR2AP1 OR2T35 OR6C2 OR6C4 OR6C70 OR6C1 OR6C75 OR6C74 OR6C3 OR2T1 OR2T2 OR6C65 OR5AP2 OR2AG1	3.43e-10	685	88	19	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR8A1 OR8K1 OR52I1 OR5M9 OR2T27 OR2AP1 OR2T35 OR6C2 OR6C4 OR6C70 OR6C1 OR6C75 OR6C74 OR6C3 OR2T1 OR2T2 OR6C65 OR5AP2 OR2AG1	3.97e-10	691	88	19	PS50262
Domain	GPCR_Rhodpsn	OR8A1 OR8K1 OR52I1 OR5M9 OR2T27 OR2AP1 OR2T35 OR6C2 OR6C4 OR6C70 OR6C1 OR6C75 OR6C74 OR6C3 OR2T1 OR2T2 OR6C65 OR5AP2 OR2AG1	4.07e-10	692	88	19	IPR000276
Domain	Ion_trans_N	HCN4 HCN1 HCN3 HCN2	4.60e-10	4	88	4	PF08412
Domain	Ion_trans_N	HCN4 HCN1 HCN3 HCN2	4.60e-10	4	88	4	IPR013621
Domain	K_chnl_volt-dep_EAG/ELK/ERG	HCN4 HCN1 HCN3 HCN2 KCNH5	4.01e-09	14	88	5	IPR003938
Domain	CNMP_BINDING_1	HCN4 HCN1 HCN3 HCN2 KCNH5	3.77e-07	32	88	5	PS00888
Domain	CNMP_BINDING_2	HCN4 HCN1 HCN3 HCN2 KCNH5	3.77e-07	32	88	5	PS00889
Domain	cNMP	HCN4 HCN1 HCN3 HCN2 KCNH5	5.17e-07	34	88	5	SM00100
Domain	cNMP_binding	HCN4 HCN1 HCN3 HCN2 KCNH5	5.17e-07	34	88	5	PF00027
Domain	cNMP-bd_dom	HCN4 HCN1 HCN3 HCN2 KCNH5	6.01e-07	35	88	5	IPR000595
Domain	CNMP_BINDING_3	HCN4 HCN1 HCN3 HCN2 KCNH5	6.01e-07	35	88	5	PS50042
Domain	cNMP-bd-like	HCN4 HCN1 HCN3 HCN2 KCNH5	9.19e-07	38	88	5	IPR018490
Domain	-	HCN4 HCN1 HCN3 HCN2 KCNH5	3.02e-06	48	88	5	2.60.120.10
Domain	RmlC-like_jellyroll	HCN4 HCN1 HCN3 HCN2 KCNH5	4.10e-06	51	88	5	IPR014710
Domain	Ion_trans_dom	HCN4 HCN1 HCN3 HCN2 KCNH5 ITPR3	1.63e-05	114	88	6	IPR005821
Domain	Ion_trans	HCN4 HCN1 HCN3 HCN2 KCNH5 ITPR3	1.63e-05	114	88	6	PF00520
Domain	cNMP-bd_CS	HCN4 HCN1 HCN2	5.41e-05	16	88	3	IPR018488
Domain	LAMININ_IVB	LAMB4 LAMB1	6.56e-05	3	88	2	PS51116
Domain	Laminin_IV_B	LAMB4 LAMB1	6.56e-05	3	88	2	IPR013015
Domain	LCCL	DCBLD1 CRISPLD1	3.25e-04	6	88	2	PS50820
Domain	LCCL	DCBLD1 CRISPLD1	3.25e-04	6	88	2	SM00603
Domain	LCCL	DCBLD1 CRISPLD1	3.25e-04	6	88	2	PF03815
Domain	LCCL	DCBLD1 CRISPLD1	3.25e-04	6	88	2	IPR004043
Domain	-	DCBLD1 CRISPLD1	3.25e-04	6	88	2	2.170.130.20
Domain	EGF_1	LAMB4 FAT4 HMCN1 CLEC14A HYAL3 LAMB1	1.30e-03	255	88	6	PS00022
Domain	EGF-like_CS	LAMB4 FAT4 HMCN1 CLEC14A HYAL3 LAMB1	1.46e-03	261	88	6	IPR013032
Domain	EGF_2	LAMB4 FAT4 HMCN1 CLEC14A HYAL3 LAMB1	1.58e-03	265	88	6	PS01186
Domain	Laminin_N	LAMB4 LAMB1	2.52e-03	16	88	2	IPR008211
Domain	LAMININ_NTER	LAMB4 LAMB1	2.52e-03	16	88	2	PS51117
Domain	Laminin_N	LAMB4 LAMB1	2.52e-03	16	88	2	PF00055
Domain	LamNT	LAMB4 LAMB1	2.52e-03	16	88	2	SM00136
Domain	EGF	FAT4 HMCN1 CLEC14A HYAL3 LAMB1	5.08e-03	235	88	5	SM00181
Domain	EGF-like_dom	FAT4 HMCN1 CLEC14A HYAL3 LAMB1	6.46e-03	249	88	5	IPR000742
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR8A1 OR8K1 OR52I1 OR5M9 OR2T27 OR2AP1 OR2T35 OR6C2 OR6C4 OR6C70 OR2T7 OR6C1 OR6C75 OR6C74 OR52E1 OR6C3 OR2T1 OR2T2 OR6C65 OR5AP2 OR2AG1	4.81e-16	417	70	21	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR8A1 OR8K1 OR52I1 OR5M9 OR2T27 OR2AP1 OR2T35 OR6C2 OR6C4 OR6C70 OR2T7 OR6C1 OR6C75 OR6C74 RBP3 OR52E1 OR6C3 OR2T1 OR2T2 OR6C65 OR5AP2 ITPR3 OR2AG1	1.84e-14	636	70	23	M41834
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR8A1 OR8K1 OR52I1 OR5M9 OR2T27 OR6C2 OR6C4 OR6C70 OR6C1 OR6C75 OR6C74 OR6C3 OR2T1 OR2T2 OR6C65 OR5AP2 OR2AG1	4.56e-12	389	70	17	M14091
Pathway	REACTOME_POTASSIUM_CHANNELS	HCN4 HCN1 HCN3 HCN2 KCNH5	1.24e-04	98	70	5	MM14545
Pathway	REACTOME_POTASSIUM_CHANNELS	HCN4 HCN1 HCN3 HCN2 KCNH5	1.57e-04	103	70	5	M1073
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR8A1 OR8K1 OR52I1 OR5M9 OR2AP1 OR2T35 OR6C2 OR6C70 OR6C1 OR6C75 OR6C74 OR6C3 OR2T1 OR6C65 OR5AP2 OR2AG1	6.56e-16	340	91	16	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR8A1 OR8K1 OR52I1 OR5M9 OR2AP1 OR2T35 OR6C2 OR6C70 OR6C1 OR6C75 OR6C74 OR6C3 OR2T1 OR6C65 OR5AP2 OR2AG1	6.56e-16	340	91	16	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR8A1 OR8K1 OR52I1 OR5M9 OR2AP1 OR2T35 OR6C2 OR6C70 OR6C1 OR6C75 OR6C74 OR6C3 OR2T1 OR6C65 OR5AP2 OR2AG1	7.53e-16	343	91	16	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR8A1 OR8K1 OR52I1 OR5M9 OR2AP1 OR2T35 OR6C2 OR6C70 OR6C1 OR6C75 OR6C74 OR6C3 OR2T1 OR6C65 OR5AP2 OR2AG1	8.63e-16	346	91	16	14611657
Pubmed	Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.	OR6C2 OR6C4 OR6C70 OR6C1 OR6C75 OR6C74 OR6C3 OR6C65	1.14e-15	24	91	8	24152035
Pubmed	Functional expression of the human HCN3 channel.	HCN4 HCN1 HCN3 HCN2	4.38e-11	4	91	4	16043489
Pubmed	Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.	HCN4 HCN1 HCN3 HCN2	4.38e-11	4	91	4	9405696
Pubmed	Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.	HCN4 HCN1 HCN3 HCN2	4.38e-11	4	91	4	12928435
Pubmed	Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases.	HCN4 HCN1 HCN3 HCN2	4.38e-11	4	91	4	21615589
Pubmed	Hyperpolarization-activated and cyclic nucleotide-gated channels are differentially expressed in juxtaglomerular cells in the olfactory bulb of mice.	HCN4 HCN1 HCN3 HCN2	4.38e-11	4	91	4	20140458
Pubmed	Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder.	HCN4 HCN1 HCN3 HCN2	4.38e-11	4	91	4	22748890
Pubmed	Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.	HCN4 HCN1 HCN3 HCN2	4.38e-11	4	91	4	9630217
Pubmed	Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction.	HCN4 HCN1 HCN3 HCN2	2.19e-10	5	91	4	15564593
Pubmed	Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice.	HCN4 HCN1 HCN3 HCN2	2.19e-10	5	91	4	34429357
Pubmed	Transcription profiling of HCN-channel isotypes throughout mouse cardiac development.	HCN4 HCN1 HCN3 HCN2	1.53e-09	7	91	4	19421833
Pubmed	The human olfactory receptor gene family.	OR8A1 OR8K1 OR52I1 OR5M9 OR2T27 OR2AP1 OR2T35 OR6C4 OR2T7 OR6C74 OR2T1 OR2T2 OR2AG1	1.72e-09	541	91	13	14983052
Pubmed	International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.	HCN4 HCN1 HCN3 HCN2	9.10e-09	10	91	4	16382102
Pubmed	HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age-dependent changes.	HCN4 HCN1 HCN2	1.73e-08	3	91	3	33181864
Pubmed	Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart.	HCN4 HCN1 HCN2	1.73e-08	3	91	3	22652004
Pubmed	Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating.	HCN4 HCN1 HCN2	1.73e-08	3	91	3	21187420
Pubmed	Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart.	HCN4 HCN1 HCN2	1.73e-08	3	91	3	21945247
Pubmed	Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.	HCN4 HCN1 HCN2	1.73e-08	3	91	3	22006928
Pubmed	A family of hyperpolarization-activated mammalian cation channels.	HCN1 HCN3 HCN2	1.73e-08	3	91	3	9634236
Pubmed	Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.	HCN4 HCN1 HCN3 HCN2	4.30e-08	14	91	4	29107716
Pubmed	Hyperpolarization-activated cyclic nucleotide-gated channels in olfactory sensory neurons regulate axon extension and glomerular formation.	OR8A1 HCN4 HCN1 HCN2	5.86e-08	15	91	4	21147989
Pubmed	Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia.	HCN1 HCN3 HCN2	6.92e-08	4	91	3	25042871
Pubmed	Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons.	HCN1 HCN3 HCN2	6.92e-08	4	91	3	26966193
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR8A1 OR8K1 OR5M9 OR2T7 OR6C1 OR2T1 OR2T2 OR2AG1	1.18e-07	219	91	8	12213199
Pubmed	Functional coupling of Tmem74 and HCN1 channels regulates anxiety-like behavior in BLA neurons.	HCN1 HCN3 HCN2	1.73e-07	5	91	3	30886335
Pubmed	Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse.	HCN4 HCN1 HCN2	3.45e-07	6	91	3	25761792
Pubmed	Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts.	HCN4 HCN3 HCN2	6.02e-07	7	91	3	27956497
Pubmed	Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart.	HCN4 HCN1 HCN2	3.75e-06	12	91	3	17482496
Pubmed	Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.	OR2T27 OR2T35 OR2T7 OR2T2	6.58e-06	46	91	4	32126975
Pubmed	Compartmental distribution of hyperpolarization-activated cyclic-nucleotide-gated channel 2 and hyperpolarization-activated cyclic-nucleotide-gated channel 4 in thalamic reticular and thalamocortical relay neurons.	HCN4 HCN2	6.77e-06	2	91	2	16806719
Pubmed	Voltage-dependent opening of HCN channels: Facilitation or inhibition by the phytoestrogen, genistein, is determined by the activation status of the cyclic nucleotide gating ring.	HCN1 HCN2	6.77e-06	2	91	2	19524546
Pubmed	Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4.	HCN4 HCN2	6.77e-06	2	91	2	12813043
Pubmed	The Hyperpolarization-Activated HCN4 Channel is Important for Proper Maintenance of Oscillatory Activity in the Thalamocortical System.	HCN4 HCN2	6.77e-06	2	91	2	30877792
Pubmed	Hyperpolarization-activated cyclic nucleotide-modulated 'HCN' channels confer regular and faster rhythmicity to beating mouse embryonic stem cells.	HCN3 HCN2	6.77e-06	2	91	2	18033814
Pubmed	Two pacemaker channels from human heart with profoundly different activation kinetics.	HCN4 HCN2	6.77e-06	2	91	2	10228147
Pubmed	Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels.	HCN1 HCN2	6.77e-06	2	91	2	12034718
Pubmed	HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease.	HCN1 HCN2	6.77e-06	2	91	2	21076425
Pubmed	In vitro characterization of HCN channel kinetics and frequency dependence in myocytes predicts biological pacemaker functionality.	HCN1 HCN2	6.77e-06	2	91	2	19171659
Pubmed	Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels.	HCN1 HCN2	6.77e-06	2	91	2	17261842
Pubmed	Intracellular Mg2+ is a voltage-dependent pore blocker of HCN channels.	HCN1 HCN2	6.77e-06	2	91	2	18579800
Pubmed	Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels.	HCN4 HCN2	6.77e-06	2	91	2	16777944
Pubmed	Hyperpolarization-activated cation current contributes to spontaneous network activity in developing neocortical cultures.	HCN1 HCN2	6.77e-06	2	91	2	22094222
Pubmed	Peripheral N- and C-terminal domains determine deactivation kinetics of HCN channels.	HCN4 HCN1	6.77e-06	2	91	2	17548059
Pubmed	Colocalization of hyperpolarization-activated, cyclic nucleotide-gated channel subunits in rat retinal ganglion cells.	HCN4 HCN1	6.77e-06	2	91	2	21456027
Pubmed	Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli.	HCN4 HCN1	6.77e-06	2	91	2	11675786
Pubmed	Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy.	HCN1 HCN2	6.77e-06	2	91	2	17931874
Pubmed	Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus.	HCN1 HCN2	6.77e-06	2	91	2	12890777
Pubmed	Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells.	HCN4 HCN2	6.77e-06	2	91	2	12194012
Pubmed	Case-control pharmacogenetic study of HCN1/HCN2 variants and genetic generalized epilepsies.	HCN1 HCN2	6.77e-06	2	91	2	29047147
Pubmed	Functional expression of the hyperpolarization-activated, non-selective cation current I(f) in immortalized HL-1 cardiomyocytes.	HCN1 HCN2	6.77e-06	2	91	2	12433951
Pubmed	An arginine residue in the pore region is a key determinant of chloride dependence in cardiac pacemaker channels.	HCN1 HCN2	6.77e-06	2	91	2	15644313
Pubmed	A leucine zipper motif essential for gating of hyperpolarization-activated channels.	HCN1 HCN2	6.77e-06	2	91	2	23048023
Pubmed	HCN2 and HCN1 channels govern the regularity of autonomous pacemaking and synaptic resetting in globus pallidus neurons.	HCN1 HCN2	6.77e-06	2	91	2	15525777
Pubmed	HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2.	HCN1 HCN2	6.77e-06	2	91	2	22948144
Pubmed	HCN3 ion channels: roles in sensory neuronal excitability and pain.	HCN3 HCN2	6.77e-06	2	91	2	31290157
Pubmed	HCN3 contributes to the ventricular action potential waveform in the murine heart.	HCN1 HCN3	6.77e-06	2	91	2	21903939
Pubmed	Functional heteromerization of HCN1 and HCN2 pacemaker channels.	HCN1 HCN2	6.77e-06	2	91	2	11133998
Pubmed	Minimal molecular determinants of isoform-specific differences in efficacy in the HCN channel family.	HCN1 HCN2	6.77e-06	2	91	2	29980633
Pubmed	Downregulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in the hippocampus of patients with medial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS).	HCN1 HCN2	6.77e-06	2	91	2	32543742
Pubmed	MinK-related peptide 1: A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation.	HCN1 HCN2	6.77e-06	2	91	2	11420311
Pubmed	Molecular composition and functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells.	HCN4 HCN1	6.77e-06	2	91	2	19135060
Pubmed	Processing of retinal signals in normal and HCN deficient mice.	HCN1 HCN2	6.77e-06	2	91	2	22279546
Pubmed	Molecular basis of the effect of potassium on heterologously expressed pacemaker (HCN) channels.	HCN1 HCN2	6.77e-06	2	91	2	12562911
Pubmed	Single-channel properties support a potential contribution of hyperpolarization-activated cyclic nucleotide-gated channels and If to cardiac arrhythmias.	HCN4 HCN2	6.77e-06	2	91	2	15687126
Pubmed	Control of heart rate by cAMP sensitivity of HCN channels.	HCN4 HCN2	6.77e-06	2	91	2	19570998
Pubmed	Mechanotransduction and hyperpolarization-activated currents contribute to spontaneous activity in mouse vestibular ganglion neurons.	HCN1 HCN2	6.77e-06	2	91	2	24638995
Pubmed	Proteolytic processing of HCN2 and co-assembly with HCN4 in the generation of cardiac pacemaker channels.	HCN4 HCN2	6.77e-06	2	91	2	19574228
Pubmed	Evolutionary emergence of N-glycosylation as a variable promoter of HCN channel surface expression.	HCN1 HCN2	6.77e-06	2	91	2	20130205
Pubmed	HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels.	HCN4 HCN2	6.77e-06	2	91	2	17553794
Pubmed	KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents.	HCN4 HCN2	2.03e-05	3	91	2	12856183
Pubmed	Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits.	HCN1 HCN2	2.03e-05	3	91	2	22880098
Pubmed	HCN channels expressed in the inner ear are necessary for normal balance function.	HCN1 HCN2	2.03e-05	3	91	2	22090507
Pubmed	A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase.	HCN4 HCN2	2.03e-05	3	91	2	16079136
Pubmed	EP3 activation facilitates bladder excitability via HCN channels on ICCs.	HCN4 HCN1	2.03e-05	3	91	2	28131828
Pubmed	Interaction of the pacemaker channel HCN1 with filamin A.	HCN1 HCN2	2.03e-05	3	91	2	15292205
Pubmed	Impaired dendritic expression and plasticity of h-channels in the fmr1(-/y) mouse model of fragile X syndrome.	HCN1 HCN2	2.03e-05	3	91	2	22662315
Pubmed	Transcriptional control of pacemaker channel genes HCN2 and HCN4 by Sp1 and implications in re-expression of these genes in hypertrophied myocytes.	HCN4 HCN2	2.03e-05	3	91	2	19471099
Pubmed	Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.	HCN4 HCN1 HCN2	2.23e-05	21	91	3	30270038
Pubmed	Composite co-activator ARC mediates chromatin-directed transcriptional activation.	MED24 ACAD8 MED23	2.95e-05	23	91	3	10235267
Pubmed	PDK1-AKT signaling pathway regulates the expression and function of cardiac hyperpolarization-activated cyclic nucleotide-modulated channels.	HCN4 HCN2	4.05e-05	4	91	2	32184125
Pubmed	Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice.	HCN1 HCN2	4.05e-05	4	91	2	21593326
Pubmed	Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson's disease.	HCN1 HCN3	4.05e-05	4	91	2	21233488
Pubmed	Dendritic excitability of mouse frontal cortex pyramidal neurons is shaped by the interaction among HCN, Kir2, and Kleak channels.	HCN1 HCN2	6.74e-05	5	91	2	16177047
Pubmed	Homozygous MED25 mutation implicated in eye-intellectual disability syndrome.	MED24 MED23	6.74e-05	5	91	2	25792360
Pubmed	Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria.	HCN4 HCN1 HCN2	7.39e-05	31	91	3	17473172
Pubmed	Differential impact of Lhx2 deficiency on expression of class I and class II odorant receptor genes in mouse.	OR8A1 OR52I1 OR2AG1	8.93e-05	33	91	3	17350283
Pubmed	Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation.	HCN4 HCN2	1.01e-04	6	91	2	26005035
Pubmed	Mapping HSA10 homologous loci in cattle.	RBP3 IL2RA	1.41e-04	7	91	2	1655359
Pubmed	Deletion in the N-terminal half of olfactomedin 1 modifies its interaction with synaptic proteins and causes brain dystrophy and abnormal behavior in mice.	OLFM3 HCN3 TUBGCP2	1.48e-04	39	91	3	24095980
Pubmed	TFIIH is negatively regulated by cdk8-containing mediator complexes.	ERCC3 MED23	1.88e-04	8	91	2	10993082
Pubmed	Detection and identification of transcription factors as interaction partners of alien in vivo.	ERCC3 MED23	1.88e-04	8	91	2	17438371
Pubmed	The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1.	MED24 MED23	2.41e-04	9	91	2	9989412
Pubmed	Dchs1-Fat4 regulation of osteogenic differentiation in mouse.	FAT4 SP7	3.67e-04	11	91	2	31358536
Pubmed	NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function.	HCN4 HCN2	4.39e-04	12	91	2	14633990
Pubmed	Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain.	FAT4 NAV1	4.39e-04	12	91	2	23342162
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	HCN4 HCN1 HCN3 HCN2	4.99e-04	139	91	4	16985003
Interaction	HCN4 interactions	HCN4 HCN1 HCN3 HCN2	2.32e-08	9	76	4	int:HCN4
Interaction	HCN3 interactions	HCN4 HCN1 HCN3	8.32e-06	11	76	3	int:HCN3
Interaction	HCN2 interactions	HCN4 HCN1 HCN2	1.43e-05	13	76	3	int:HCN2
Interaction	PEX5L interactions	HCN4 HCN1 HCN3 HCN2	5.12e-05	54	76	4	int:PEX5L
Cytoband	12q13.2	OR2AP1 OR6C2 OR6C4 OR6C70 OR6C1 OR6C75 OR6C74 OR6C3 OR6C65	1.86e-15	55	91	9	12q13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr12q13	KRT3 OR2AP1 OR6C2 OR6C4 OR6C70 OR6C1 OR6C75 OR6C74 OR6C3 LALBA OR6C65 SP7	5.25e-11	423	91	12	chr12q13
Cytoband	1q44	OR2T27 OR2T35 OR2T7 OR2T1 OR2T2	2.84e-06	110	91	5	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2T27 OR2T35 OR2T7 OR2T1 OR2T2	5.98e-06	128	91	5	chr1q44
GeneFamily	Olfactory receptors, family 6	OR6C2 OR6C4 OR6C70 OR6C1 OR6C75 OR6C74 OR6C3 OR6C65	1.86e-11	51	70	8	153
GeneFamily	Cyclic nucleotide gated channels	HCN4 HCN1 HCN3 HCN2	4.25e-08	10	70	4	250
GeneFamily	Olfactory receptors, family 2	OR2T27 OR2AP1 OR2T35 OR2T7 OR2T1 OR2T2 OR2AG1	2.68e-07	113	70	7	149
GeneFamily	Laminin subunits	LAMB4 LAMB1	9.51e-04	12	70	2	626
Coexpression	KONDO_PROSTATE_CANCER_WITH_H3K27ME3	OR8A1 LAMB4 OR6C70 WNT8B OR6C74 LALBA OR2AG1	3.06e-06	194	84	7	M7281
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAT4 VWF CLEC14A NAV1 CRISPLD1 ITPR3	1.83e-06	183	89	6	3427f3cbe6ea81709750e7dd3ff378f03ae65eab
ToppCell	facs-Heart-LA-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B VWF TBKBP1 HMCN1 CLEC14A PKHD1L1	1.95e-06	185	89	6	1ecfca049c0c1110fd1b2256db7cb7abda6afb04
ToppCell	facs-Heart-LA-18m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B VWF TBKBP1 HMCN1 CLEC14A PKHD1L1	1.95e-06	185	89	6	b6df1412b579d40ed5df806f9c54bd1fbb9a1e15
ToppCell	droplet-Lung-LUNG-1m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF HMCN1 CLEC14A NYNRIN LRRC4 CRISPLD1	2.35e-06	191	89	6	9fc674a58f20b47255e4457d5195c8cff17b0414
ToppCell	droplet-Lung-LUNG-1m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF HMCN1 CLEC14A NYNRIN LRRC4 CRISPLD1	2.35e-06	191	89	6	c379a499dabf3c9ed80f47adbb2d949821c5b053
ToppCell	droplet-Lung-1m-Endothelial-venous_endothelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VWF HMCN1 CLEC14A NYNRIN LRRC4 CRISPLD1	2.42e-06	192	89	6	1990dc8a81594018a5bf596be99d0b5f0af0f58f
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	UNC13B ANKRD29 SLFN13 EXPH5 MOCOS ITPR3	2.42e-06	192	89	6	d3634574b2e8d2ded6446969361b70761b331aea
ToppCell	droplet-Lung-1m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VWF HMCN1 CLEC14A NYNRIN LRRC4 CRISPLD1	2.42e-06	192	89	6	845cc9c18b4436b07dd3ce7980052683937546d2
ToppCell	droplet-Lung-1m-Endothelial-venous_endothelial-vein_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VWF HMCN1 CLEC14A NYNRIN LRRC4 CRISPLD1	2.42e-06	192	89	6	c72a082c93a8825adbfef37f889ba3a7052f201b
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF TBKBP1 HMCN1 WTIP CLEC14A ITPR3	2.97e-06	199	89	6	1295f34a350bf48987e2fad411aaac3630efd3f1
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2\|Thalamus / BrainAtlas - Mouse McCarroll V32	VWF CLEC14A MOCOS SLC23A3 ITPR3	7.12e-06	133	89	5	29b0c2c682c6b97823e7d8d8ba1f5114044b30ba
ToppCell	facs-Aorta-Heart-3m-Endothelial-endocardial_endothelial_cells\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADH7 VWF CLEC14A ACP3 PKHD1L1	2.14e-05	167	89	5	a4a795751644b22af616335379e64ae95175180c
ToppCell	facs-Heart-RA-18m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B VWF TBKBP1 HMCN1 PKHD1L1	2.20e-05	168	89	5	06dc5b2d356d3a9454b10bba6f3b9ead2a0a7d46
ToppCell	facs-Heart-RA-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B VWF TBKBP1 HMCN1 PKHD1L1	2.20e-05	168	89	5	1002f058a340763e3d8de0bd1f0547a903526ec6
ToppCell	facs-Heart-LV-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B VWF HMCN1 DCBLD1 PKHD1L1	2.47e-05	172	89	5	f2c17c49b375b28ad47dc6cabda62f1c238023dd
ToppCell	facs-Heart-LV-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B VWF HMCN1 DCBLD1 PKHD1L1	2.47e-05	172	89	5	6ab4f01098dddb789df298ddf97b3c384405ee6c
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKRD29 FAT4 HMCN1 WTIP KIAA0586	2.83e-05	177	89	5	8ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCell	LPS-antiTNF-Hematopoietic_Meg-Ery-Erythroid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AMFR HYAL3 UCP2 PKHD1L1 RHCE	2.91e-05	178	89	5	eafacc8cd3e986d6ca309e05b6e241331a584fa5
ToppCell	LPS-antiTNF-Hematopoietic_Meg-Ery\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AMFR HYAL3 UCP2 PKHD1L1 RHCE	2.91e-05	178	89	5	6a5c31e976852edc7d9e899da8e2a1bf23d36759
ToppCell	LPS-antiTNF-Hematopoietic_Meg-Ery-Erythroid-Erythroid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AMFR HYAL3 UCP2 PKHD1L1 RHCE	2.91e-05	178	89	5	370749834a11d981e9ede26d5f63f0ecb551c015
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAT4 VWF CLEC14A NAV1 CRISPLD1	3.15e-05	181	89	5	4d7793026373cbcf04b15c77f95f1025d07d4c00
ToppCell	facs-Lung-nan-3m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B ANKRD29 VWF PKHD1L1 CRISPLD1	3.32e-05	183	89	5	12e876d6205af8aad74265c668b5e95b9e7487f3
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B VWF HMCN1 LRRC4 PKHD1L1	3.32e-05	183	89	5	6c4a09c02e30e1f24dde39f8cb8c5b453826ee2e
ToppCell	droplet-Heart-4Chambers-21m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLCD3B VWF TBKBP1 HMCN1 CLEC14A	3.40e-05	184	89	5	f17d713af4a97dff4eeeab24c405677ef2ffcf84
ToppCell	droplet-Lung-nan-3m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADH7 VWF CLEC14A PKHD1L1 CRISPLD1	3.49e-05	185	89	5	eeb6f55a6f79adf80247baa2c4b0df44553557ad
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ANKRD29 VWF MED23 CRISPLD1 ITPR3	3.49e-05	185	89	5	87151ab95530e70d61328b336518df58db584acb
ToppCell	droplet-Heart-nan-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B TLCD3B VWF TBKBP1 CLEC14A	3.49e-05	185	89	5	a32d5cb596ebac80eb1ac301055e65d420879ec8
ToppCell	LPS_only-Hematopoietic_Meg-Ery-Erythroid-Erythroid\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AMFR HYAL3 UCP2 PKHD1L1 RHCE	3.59e-05	186	89	5	e5014443e9d6e25943308483e20d48b776ae5373
ToppCell	LPS_only-Hematopoietic_Meg-Ery-Erythroid\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AMFR HYAL3 UCP2 PKHD1L1 RHCE	3.59e-05	186	89	5	affc246a1091e44dc85a5e237c778a7541d5a2b4
ToppCell	LPS_only-Hematopoietic_Meg-Ery\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AMFR HYAL3 UCP2 PKHD1L1 RHCE	3.59e-05	186	89	5	40d1e15402fdfb3b5ae850a2070cd4b68fda3159
ToppCell	metastatic_Lymph_Node-Endothelial_cells-Tumor_ECs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	ANKRD29 FAT4 VWF CLEC14A KIAA0586	3.68e-05	187	89	5	2713f526f86911fbbf6c7a3e69230f2e6bde31c3
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UNC13B ADH7 VWF CLEC14A PKHD1L1	3.68e-05	187	89	5	12129e02638c20d9b7c1c6e512d48bfd966e1029
ToppCell	facs-Heart-LA-24m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B VWF HMCN1 CLEC14A PKHD1L1	3.68e-05	187	89	5	d9943e65eedab73d141eae524e2411653a751705
ToppCell	facs-Heart-LA-24m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B VWF HMCN1 CLEC14A PKHD1L1	3.68e-05	187	89	5	7b13c3b67d66f3afb410141d5471c9e78a4d8623
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UNC13B ADH7 VWF CLEC14A PKHD1L1	3.68e-05	187	89	5	83930ef55191eff9006113feaeabb3c2fa21fd05
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF CLEC14A NAV1 CRISPLD1 ITPR3	3.87e-05	189	89	5	9da012fdfa9a8d488cab710a463a1d70e89f990c
ToppCell	droplet-Pancreas-PANCREAS-30m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF HMCN1 CLEC14A LAMB1 CRISPLD1	3.97e-05	190	89	5	9d5242759546be0089981ef1877e4ed5f81face5
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF CLEC14A NAV1 CRISPLD1 ITPR3	3.97e-05	190	89	5	d87b9e9ca863270a9c7f61674271a6440c97d1f4
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UNC13B ADH7 VWF NYNRIN PKHD1L1	3.97e-05	190	89	5	3cf464664d6aa22b212e60b70885953887e92483
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ANKRD29 OLFM3 VWF CLEC14A NAV1	4.07e-05	191	89	5	b2c86cde341fe350143658c8a8a4a9edbce3f19b
ToppCell	droplet-Heart-HEART-1m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B VWF TBKBP1 HMCN1 PKHD1L1	4.07e-05	191	89	5	4bfdf44d4402a42530d30c89d94946acdda4321b
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF CLEC14A NAV1 CRISPLD1 ITPR3	4.07e-05	191	89	5	3307dbccadb09c62b0e1c0235ec89bb294d748c3
ToppCell	facs-Heart-LA-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B VWF HMCN1 CLEC14A PKHD1L1	4.17e-05	192	89	5	14a816ef116aa992f86edab411f043cf7d07fe04
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF CLEC14A NAV1 CRISPLD1 ITPR3	4.17e-05	192	89	5	285a9d332a1e07b94f222d4b518dd56928b9e075
ToppCell	facs-Heart-LA-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B VWF HMCN1 CLEC14A PKHD1L1	4.17e-05	192	89	5	847822514d747a21d5eb40e04ba9a023fd32bd65
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating1_(8)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	UNC13B ANKRD29 EXPH5 UCP2 SDR42E1	4.27e-05	193	89	5	979980369d2dbee9dc4770d72b93037abd7786eb
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B VWF TBKBP1 HMCN1 PKHD1L1	4.38e-05	194	89	5	c5e77650d7abee339ec38fa78a622bb124db3fa5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 OLFM3 VWF CLEC14A NAV1	4.38e-05	194	89	5	b0c15e7e4bcf30856fb628dedd7ba82df33489f5
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B VWF TBKBP1 HMCN1 PKHD1L1	4.49e-05	195	89	5	df644b4c3ddccd34614ece5a2378000e6bc0fa10
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_B1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TMEM61 HMCN1 HCN3 POLQ	4.85e-05	100	89	4	cb0deaf1c33d2789417e93cc01d94e34a611d20a
ToppCell	LPS_anti-TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	AMFR HYAL3 UCP2 HCN2 PKHD1L1	4.94e-05	199	89	5	565404c155dfac57c020a8f2d09cbf756da20ffd
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF HMCN1 WTIP CLEC14A DCBLD1	4.94e-05	199	89	5	d95d78b2ebc9a20532466e4d4be579b4faf6776f
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF HMCN1 WTIP CLEC14A DCBLD1	4.94e-05	199	89	5	cdcfca94baba66e213cc3ffb0cfb4c75d6ab44ec
ToppCell	LPS_anti-TNF-Hematopoietic_Erythro-Megakary\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	AMFR HYAL3 UCP2 HCN2 PKHD1L1	4.94e-05	199	89	5	6c174dbcc25b980f10a3d1dfe39e613acac73bb6
ToppCell	LPS_anti-TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	AMFR HYAL3 UCP2 HCN2 PKHD1L1	4.94e-05	199	89	5	284ee9632413f6404fc0b0c7c393ad813db834f2
ToppCell	Severe-B_naive-13\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	WTIP OR2T2 ARMH1 SLC23A3	8.65e-05	116	89	4	f81a7c3e9cbf39124232d98e2a3a3e308137f391
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7-Slc17a6.Nptxr-Rorb_(Deep_layer_pyramidal_cells--Layer_5a)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	EXPH5 NEK11 KCNH5 SLC23A3	1.15e-04	125	89	4	be820e4db3da737101f34ea9d2848a3ceb53f417
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Rectal_Adenocarcinoma-5\|TCGA-Colorectal / Sample_Type by Project: Shred V9	UNC13B TMEM61 ACP3 SLCO6A1	1.15e-04	125	89	4	c82b4bddc98b2a2d2ee00c1392df86f9735c0623
ToppCell	Striatum-Endothelial-ENDOTHELIAL_STALK-Flt1_1\|Striatum / BrainAtlas - Mouse McCarroll V32	VWF HMCN1 CLEC14A ITPR3	1.64e-04	137	89	4	306b11b3b9e5fd562d845fb5eaa4ac982864efce
ToppCell	Striatum-Endothelial-ENDOTHELIAL_STALK\|Striatum / BrainAtlas - Mouse McCarroll V32	VWF HMCN1 CLEC14A ITPR3	1.64e-04	137	89	4	d37f425b13bc046baa1f8619b98a16b936f88ff6
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-4\|TCGA-Brain / Sample_Type by Project: Shred V9	OLFM3 FRMPD4 HCN1 KCNH5	2.10e-04	146	89	4	632f52780607c638b5d3dd3fb9251c719f162a35
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-4\|TCGA-Brain / Sample_Type by Project: Shred V9	OLFM3 FRMPD4 HCN1 KCNH5	2.27e-04	149	89	4	ff472ad641efd655905e99a9a4cacd5245ab8854
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_5\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	OR52I1 LAMB1 HCN2 IL2RA	2.90e-04	159	89	4	08a1cd71eac4322fb313324f74fe8e37998f2d7d
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_5\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	OR52I1 LAMB1 HCN2 IL2RA	2.90e-04	159	89	4	9bdfa7f5aa7753fe25b787bd43d694b6093d77eb
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	OR8A1 VWF CLEC14A HYAL3	3.12e-04	162	89	4	25bb1b9709f960fdf90faff56e874f52a8f5d17e
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_4\|356C / Donor, Lineage, Cell class and subclass (all cells)	DCBLD1 POLQ MOCOS EPG5	3.12e-04	162	89	4	7d43d59531cbefe3ac94953b7faf7156b2a31441
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LAMB4 FAT4 VWF CLEC14A	3.19e-04	163	89	4	977a970b1296234c22178420294cea73506ee02f
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	UNC13B EXPH5 KCNH5 SLC23A3	3.19e-04	163	89	4	1e8ab00ecc2d2ba35aa6745c0ed38663e26312e8
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L4-L4_IT_VISp_Rspo1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	UNC13B EXPH5 KCNH5 SLC23A3	3.19e-04	163	89	4	431221a41d396b09170476179590eaf8a55266d8
ToppCell	Adult-Mesenchymal-chondrocyte-D231\|Adult / Lineage, Cell type, age group and donor	HMCN1 NYNRIN NAV1 LAMB1	3.26e-04	164	89	4	2ba57dce5f69a88f0d1e450b9780425e2d9ca7d4
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	OLFM3 VWF CLEC14A NAV1	3.34e-04	165	89	4	a74751e0ec857aa974bec04ccc747c004a8f6e01
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 VWF CLEC14A KCNH5	3.42e-04	166	89	4	ec719368295133da2f7ff587c5329ed6db1dd56d
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage_4\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ADGB ANKRD29 CLEC14A DCBLD1	3.42e-04	166	89	4	8d5d09f25e8903d481c2097fed435e69d42ccdb5
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	UNC13B ANKRD29 HAVCR1 EXPH5	3.50e-04	167	89	4	25af48c640e67848594f5902867ba325fc105da4
ToppCell	10x3'2.3-week_17-19-Hematopoietic-HSC/MPP_and_pro-myeloid_DC_progenitor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	UNC13B ASB13 HCN3 SDR42E1	3.58e-04	168	89	4	2c42588ca9775270591485f9bf805fe8ab9c0671
ToppCell	Control-Hematopoietic_Meg-Ery\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HYAL3 UCP2 PKHD1L1 RHCE	3.66e-04	169	89	4	c2e2a7b89fe4a64d79efafdec037c4104f433061
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF HMCN1 CLEC14A CRISPLD1	3.66e-04	169	89	4	58136b8a0bf2dab45c91a053ef7225ea49ccb871
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF HMCN1 CLEC14A CRISPLD1	3.66e-04	169	89	4	04c6ed38e1d1befba5ef5f37a3c1e045a0b163d6
ToppCell	Control-Hematopoietic_Meg-Ery-Erythroid\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HYAL3 UCP2 PKHD1L1 RHCE	3.66e-04	169	89	4	df1fc1477bbbb285063b9b122b1ac84c87fd7fa8
ToppCell	Control-Hematopoietic_Meg-Ery-Erythroid-Erythroid\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HYAL3 UCP2 PKHD1L1 RHCE	3.66e-04	169	89	4	92986559aa4a744e8b0487b0ae035cfb1fbf9890
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGB LAMB1 LY9 ITPR3	3.74e-04	170	89	4	a121e10099faaeb60251eec162f38caf7c4238c2
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TLCD3B VWF CLEC14A CRISPLD1	3.91e-04	172	89	4	fc092a0631555d79e00ef9890cbd806e15bca2d4
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TLCD3B VWF CLEC14A CRISPLD1	3.91e-04	172	89	4	745725bd10c82017d678463b8fef0d2dcf09a8fd
ToppCell	AT1_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	ANKRD29 WTIP EXPH5 PGBD5	4.00e-04	173	89	4	3afca2a429c634af0220c1aa19ce4cf4ee3e8b3e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADGB TLCD3B SLFN13 POLQ	4.08e-04	174	89	4	84da9faff088d05233183b425385beb054c92d1b
ToppCell	LPS-IL1RA-Hematopoietic_Meg-Ery-Erythroid-Erythroid\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HYAL3 UCP2 PKHD1L1 RHCE	4.17e-04	175	89	4	e4c9b3c6bde390a3892b112b673f93e118220eb9
ToppCell	LPS-IL1RA-Hematopoietic_Meg-Ery-Erythroid\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HYAL3 UCP2 PKHD1L1 RHCE	4.17e-04	175	89	4	4d36da7399c62c170cb603957b35a35efb2c3fbe
ToppCell	LPS-IL1RA-Hematopoietic_Meg-Ery\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HYAL3 UCP2 PKHD1L1 RHCE	4.17e-04	175	89	4	2c39c1b112e873403ad2add8595cc256bf0b97a6
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGB LAMB1 LY9 ITPR3	4.17e-04	175	89	4	f7cd2ef79d91d64976fcdb5f1e7343b24ba27456
ToppCell	wk_20-22-Endothelial-Blood_vessel_endothelial-OMD+_endo\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	VWF HMCN1 CLEC14A CRISPLD1	4.26e-04	176	89	4	52af8f717dbd3b59eeb868b8b7b256a8f3e57d7a
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF CLEC14A CRISPLD1 ITPR3	4.26e-04	176	89	4	27e6b3ae41068d6cfdda3d46da7df2a27567140e
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF CLEC14A CRISPLD1 ITPR3	4.26e-04	176	89	4	d6a5470af9592f34a741265f2ea9651c05c3add3
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-cycling_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF SLFN13 CLEC14A OR2AG1	4.45e-04	178	89	4	462111b61f37338f97ac7dc6c7da1d4316b54445
ToppCell	facs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADH7 VWF PKHD1L1 CRISPLD1	4.45e-04	178	89	4	9f59a9af232d77bb55603a7776dbf9749ea652f2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 VWF CLEC14A NAV1	4.45e-04	178	89	4	5f779a66aa42d1d8e8af17b4a08d5dcc733efd4c
ToppCell	LPS-IL1RA+antiTNF-Hematopoietic_Meg-Ery\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HYAL3 UCP2 PKHD1L1 RHCE	4.54e-04	179	89	4	7329b45376a9e9a4fe34d4aa0b33af6dda0a8e3b
ToppCell	Ciliated_cells-A-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	ADH7 TMEM61 NEK11 MOCOS	4.54e-04	179	89	4	1c41314b6fcfcac8d62034e7037570120d58f20f
ToppCell	LPS-IL1RA+antiTNF-Hematopoietic_Meg-Ery-Erythroid\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HYAL3 UCP2 PKHD1L1 RHCE	4.54e-04	179	89	4	6e4740f99f66d3e9348fa5057cf1030454819aa8
ToppCell	LPS-IL1RA+antiTNF-Hematopoietic_Meg-Ery-Erythroid-Erythroid\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HYAL3 UCP2 PKHD1L1 RHCE	4.54e-04	179	89	4	ee60ac43fb62c09967a26bbcf9306ac5ea2bdc1e
ToppCell	facs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ANKRD29 VWF CLEC14A CRISPLD1	4.64e-04	180	89	4	67c5068b660cd5e727a665cefe3bd5f8ae887221
Drug	HCNs	HCN4 HCN1 HCN3 HCN2	9.19e-07	20	87	4	CID006857665
Disease	meningitis (biomarker_via_orthology)	HCN1 HCN2	8.01e-06	2	84	2	DOID:9471 (biomarker_via_orthology)
Disease	sick sinus syndrome (implicated_via_orthology)	HCN4 HCN1	2.40e-05	3	84	2	DOID:13884 (implicated_via_orthology)
Disease	response to silica exposure, pneumoconiosis	LAMB4 LAMB1	7.96e-05	5	84	2	EFO_0005853, MONDO_0015926
Disease	remnant cholesterol measurement	HAVCR1 TBKBP1 NYNRIN RHCE	2.61e-04	108	84	4	EFO_0010815
Disease	free cholesterol measurement	HAVCR1 TBKBP1 NYNRIN RHCE	3.11e-04	113	84	4	EFO_0008591
Disease	total lipids in small LDL	HAVCR1 TBKBP1 NYNRIN	3.30e-04	47	84	3	EFO_0022168
Disease	total lipids in LDL measurement	HAVCR1 TBKBP1 NYNRIN	4.45e-04	52	84	3	EFO_0022308
Disease	phospholipids in small LDL measurement	HAVCR1 TBKBP1 NYNRIN	6.45e-04	59	84	3	EFO_0022297
Disease	glycerate measurement	HMCN1 SLC23A3	8.21e-04	15	84	2	EFO_0021029
Disease	interleukin-2 receptor subunit alpha measurement	ASB13 IL2RA	1.62e-03	21	84	2	EFO_0010587
Disease	liver fibrosis measurement	VWF IL2RA ITPR3	1.92e-03	86	84	3	EFO_0010576
Disease	intermediate density lipoprotein measurement	HAVCR1 TBKBP1 RHCE	1.99e-03	87	84	3	EFO_0008595
Disease	lipid measurement, lipoprotein measurement	HAVCR1 TBKBP1 NYNRIN	2.19e-03	90	84	3	EFO_0004529, EFO_0004732
Disease	lipid measurement, intermediate density lipoprotein measurement	HAVCR1 TBKBP1 RHCE	2.63e-03	96	84	3	EFO_0004529, EFO_0008595

Protein segments in the cluster

Peptide	Gene	Start	Entry
LASCHMNYGTSVVVG	ADH7	291	P40394
HCLGVYTSNMTASTI	ADNP	666	Q9H2P0
CYLALSMTAVGHSIE	EPG5	1021	Q9HCE0
CTSTTAYISIHNMCA	ACAD8	116	Q9UKU7
CSSAIQTSHMVVYAT	ADGB	406	Q8N7X0
YTASPLHEACMSGSS	ASB13	116	Q8WXK3
VTKALCLHGSSYSMN	ARMH1	401	Q6PIY5
VALGYHVGSVSASTM	FAT4	806	Q6V0I7
CRDSHGTTLLMVAAY	ANKRD29	41	Q8N6D5
FSTCSSHMVVVSISY	OR6C1	236	Q96RD1
SHMVVVSISYGSCIF	OR6C1	241	Q96RD1
FSTCSSHMIVVSIAY	OR6C2	236	Q9NZP2
SHMIVVSIAYGSCIF	OR6C2	241	Q9NZP2
AHISSMLSSGASCAA	ITPR3	1546	Q14573
FSTCSSHMIVVSVSY	OR6C65	236	A6NJZ3
SHMIVVSVSYGSCIF	OR6C65	241	A6NJZ3
FSTCSSHMIVVSITY	OR6C70	236	A6NIJ9
FSTCGSHVCVMLTFY	OR52E1	236	Q8NGJ3
CSSHMTVVSLFYGAA	OR2T1	291	O43869
TCSSHIMVVSVFYGA	OR2T2	241	Q6IF00
MSRASVYAAHTLAGT	LIPM	286	Q5VYY2
AAHLVDSGNYTCMAS	LRIT2	316	A6NDA9
AVVSGSSRMSCVAHS	KRT3	21	P12035
SGYHRADVMQKSSTC	KCNH5	51	Q8NCM2
MSCRSSQSLLHSDGY	IGKV2D-26	41	A0A0A0MRZ7
TCSSHMVVVSLFYGA	OR2T7	231	P0C7T2
HSVYCSTKGALDMLT	DCXR	146	Q7Z4W1
SEMSCSYTLALAHAV	MED23	1201	Q9ULK4
CDLATTLTGTPHYMS	NEK11	186	Q8NG66
ICTMFHTSGYDTQAI	LALBA	46	P00709
FSHVLLSDTGVYTCM	LRRC4	411	Q9HBW1
NVCSMTGSSYHVKSS	EXPH5	581	Q8NEV8
SISCHFDMAVYLATG	LAMB1	341	P07942
SIYSTSDCEHGMASV	TUBGCP2	841	Q9BSJ2
CYLTDSHTSVVGMRN	MOCOS	146	Q96EN8
CSSHLTVVGMFYGAA	OR2AG1	241	Q9H205
CSSHMVVVSLFYGAA	OR2T27	241	Q8NH04
FSTCSSHMIVISLSY	OR2AP1	236	Q8NGE2
CSSHIMVVSVFYGAA	OR2T35	241	Q8NGX2
ATCYAMFIGHATALI	HCN3	336	Q9P1Z3
HKAFSTCASYLMAVT	OR5AP2	241	Q8NGF4
FSTCSSHMIVISLSY	OR6C4	236	Q8NGE1
VGATCYAMFIGHATA	HCN4	501	Q9Y3Q4
QSAHVTDTGRYLCMA	HMCN1	3771	Q96RW7
FSTCSSHMVVVSISY	OR6C74	236	A6NCV1
SHMVVVSISYGSCIF	OR6C74	241	A6NCV1
YSAHDTTVSGLQMAL	ACP3	286	P15309
LGYMISTSISHCESV	PGBD5	171	Q8N414
VGATCYAMFVGHATA	HCN1	381	O60741
ADVTCVFHIASYGMS	SDR42E1	71	Q8WUS8
GSVHYEMQSSICRAA	CRISPLD1	326	Q9H336
FSKLHMGSVAYSCTS	FRMPD4	1011	Q14CM0
TSQDMHTYAACTFLA	POLQ	546	O75417
SMASNYTGRCHAATL	HYAL3	211	O43820
GSLYMLCTGNSSHSS	IL2RA	61	P01589
HAYVCSEASSVTSMT	LY9	336	Q9HBG7
CHFDMTTYLASGGLS	LAMB4	341	A4D0S4
IGCSVAISTYSMLGH	ERCC3	401	P19447
HCTGSYVMALTAAAT	HIRA	781	P54198
CGHLVTYQDSGTMTS	DCBLD1	41	Q8N8Z6
SSSLYCRSGTSVLHM	SLFN13	131	Q68D06
GATCYAMFIGHATAL	HCN2	451	Q9UL51
ACASHVSTMASFLKG	DBNL	96	Q9UJU6
ESFMICGTLYVTNSH	OLFM3	396	Q96PB7
TCSSHLAAVGMFYGS	OR8A1	256	Q8NGG7
FSTCSSHMIVVSISY	OR6C75	236	A6NL08
SHMIVVSISYSSCIF	OR6C75	241	A6NL08
FSDLSTFVCIHMSGY	NYNRIN	1301	Q9P2P1
ALSTCGSHVGVMALY	OR52I1	241	Q8NGK6
GSQVTHSSLEMTCYD	NAV1	281	Q8NEY1
IGCASVSRSSAHMVS	SZT2	2536	Q5T011
MTDGHISCTAVEFSY	TDRD3	6	Q9H7E2
YAMLSLGACSHSRSQ	SERPINA4	86	P29622
SVTLPCHYSGAVTSM	HAVCR1	31	Q96D42
SFLMLCHVAQTYGSE	MED24	496	O75448
HSAGIYLGIAECTSM	SLCO6A1	261	Q86UG4
TCSSHLTVVIMFYGT	OR8K1	246	Q8NGG5
FSTCGSHLTAVSMFY	OR5M9	236	Q8NGP3
STCSSHMIVISISYG	OR6C3	236	Q9NZP0
ISMALAASTSSLGCY	SLC23A3	321	Q6PIS1
AAVCSITGYTHGMHT	AMFR	201	Q9UKV5
CSASGACYSLHHATM	CLEC14A	31	Q86T13
HLASTLRYCMTVSGT	TMEM61	11	Q8N0U2
AFVHAISSAGVMYTL	WNT8B	86	Q93098
ALGQYSSAGHCALTM	UCP2	246	P55851
YILMSHTSGSAAEAF	RBP3	841	P10745
SMTYVHSAVLAGGVA	RHCE	266	P18577
TCSTIGMAHYLTFDG	VWF	866	P04275
HYGSSPLAMLTAACS	SP7	11	Q8TDD2
ESIYQAMTHFACLSS	UNC13B	796	O14795
DASHSTQITCYTRAM	PKHD1L1	91	Q86WI1
MASTAGYIVSTSCKH	TLCD3B	51	Q71RH2
AMGSLYHTDCFTCDS	WTIP	241	A6NIX2
TYCGESSASSLTMAH	TYW1	606	Q9NV66
MCSASHFALITAYGD	TBKBP1	36	A7MCY6
SIYEDSCASHGPMSL	KIAA0586	1376	Q9BVV6