Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-7 ERVK-10 ERVK-24	7.88e-05	37	45	3	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-7 ERVK-10 ERVK-24	8.54e-05	38	45	3	GO:0070001
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	G2E3 RNF39 TRIM47 TRIM44 LONRF1 RNF19B	1.77e-04	372	45	6	GO:0061630
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	G2E3 RNF39 TRIM47 TRIM44 LONRF1 RNF19B	2.55e-04	398	45	6	GO:0061659
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-7 ERVK-10	2.70e-04	11	45	2	GO:0004523
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-7 ERVK-10	4.44e-04	14	45	2	GO:0003964
GeneOntologyMolecularFunction	cyclin-dependent protein serine/threonine kinase activator activity	CDK5R1 CDK5R2	5.84e-04	16	45	2	GO:0061575
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	G2E3 RNF39 TRIM47 TRIM44 LONRF1 RNF19B	6.37e-04	473	45	6	GO:0004842
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	G2E3 RNF39 TRIM47 TRIM44 LONRF1 RNF19B	9.62e-04	512	45	6	GO:0019787
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-7 ERVK-10	1.01e-03	21	45	2	GO:0035613
GeneOntologyMolecularFunction	transition metal ion binding	ERVK-5 ERVK-7 HAMP ERVK-10 ERVK-24 TRIM47 MUC2 TRIM44 RNF19B	1.16e-03	1189	45	9	GO:0046914
GeneOntologyMolecularFunction	aminoacyltransferase activity	G2E3 RNF39 TRIM47 TRIM44 LONRF1 RNF19B	1.17e-03	532	45	6	GO:0016755
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-7 ERVK-10	3.15e-03	37	45	2	GO:0016891
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-7 ERVK-10	3.32e-03	38	45	2	GO:0034061
GeneOntologyMolecularFunction	structural molecule activity	ERVK-5 ERVK-7 CHADL ERVK-10 ERVK-24 MUC2 FBN3	3.55e-03	891	45	7	GO:0005198
GeneOntologyMolecularFunction	zinc ion binding	ERVK-5 ERVK-7 ERVK-10 ERVK-24 TRIM47 TRIM44 RNF19B	3.55e-03	891	45	7	GO:0008270
GeneOntologyMolecularFunction	protein kinase activator activity	CDK5R1 CDK5R2 WNT11	4.59e-03	149	45	3	GO:0030295
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	EPHB4 FCSK CDK5R1 ERVK-7 ERVK-10 TNKS2 DGKK	4.70e-03	938	45	7	GO:0016772
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-7 ERVK-10	4.83e-03	46	45	2	GO:0016893
GeneOntologyMolecularFunction	nucleotidyltransferase activity	ERVK-7 ERVK-10 TNKS2	4.86e-03	152	45	3	GO:0016779
GeneOntologyMolecularFunction	kinase activator activity	CDK5R1 CDK5R2 WNT11	5.50e-03	159	45	3	GO:0019209
GeneOntologyMolecularFunction	cyclin-dependent protein serine/threonine kinase regulator activity	CDK5R1 CDK5R2	5.90e-03	51	45	2	GO:0016538
GeneOntologyMolecularFunction	acyltransferase activity	G2E3 RNF39 TRIM47 TRIM44 LONRF1 RNF19B	7.51e-03	775	45	6	GO:0016746
GeneOntologyBiologicalProcess	superior olivary nucleus development	CDK5R1 CDK5R2	4.65e-06	2	45	2	GO:0021718
GeneOntologyBiologicalProcess	superior olivary nucleus maturation	CDK5R1 CDK5R2	4.65e-06	2	45	2	GO:0021722
GeneOntologyBiologicalProcess	pons maturation	CDK5R1 CDK5R2	1.39e-05	3	45	2	GO:0021586
GeneOntologyBiologicalProcess	hindbrain maturation	CDK5R1 CDK5R2	9.71e-05	7	45	2	GO:0021578
GeneOntologyBiologicalProcess	central nervous system maturation	CDK5R1 CDK5R2	1.66e-04	9	45	2	GO:0021626
GeneOntologyCellularComponent	protein kinase 5 complex	CDK5R1 CDK5R2	1.36e-05	3	45	2	GO:0016533
Domain	CDK5_activator	CDK5R1 CDK5R2	5.18e-06	2	43	2	IPR004944
Domain	CDK5_activator	CDK5R1 CDK5R2	5.18e-06	2	43	2	PF03261
Domain	-	G2E3 RNF39 TRIM47 FGD2 FGD4 LONRF1 RNF19B	6.75e-05	449	43	7	3.30.40.10
Domain	WxxW_domain	MUC5B MUC2	7.72e-05	6	43	2	IPR025155
Domain	Mucin2_WxxW	MUC5B MUC2	7.72e-05	6	43	2	PF13330
Domain	Znf_RING/FYVE/PHD	G2E3 RNF39 TRIM47 FGD2 FGD4 LONRF1 RNF19B	7.75e-05	459	43	7	IPR013083
Domain	TIL	MUC5B MUC2	3.37e-04	12	43	2	PF01826
Domain	C8	MUC5B MUC2	3.37e-04	12	43	2	PF08742
Domain	Unchr_dom_Cys-rich	MUC5B MUC2	3.97e-04	13	43	2	IPR014853
Domain	C8	MUC5B MUC2	3.97e-04	13	43	2	SM00832
Domain	TIL_dom	MUC5B MUC2	4.63e-04	14	43	2	IPR002919
Domain	VWFD	MUC5B MUC2	6.09e-04	16	43	2	PS51233
Domain	VWD	MUC5B MUC2	6.09e-04	16	43	2	SM00216
Domain	VWF_type-D	MUC5B MUC2	6.09e-04	16	43	2	IPR001846
Domain	VWD	MUC5B MUC2	6.09e-04	16	43	2	PF00094
Domain	RING	G2E3 RNF39 TRIM47 LONRF1 RNF19B	6.51e-04	305	43	5	SM00184
Domain	CTCK_1	MUC5B MUC2	7.74e-04	18	43	2	PS01185
Domain	VWC_out	MUC5B MUC2	8.64e-04	19	43	2	SM00215
Domain	Znf_RING	G2E3 RNF39 TRIM47 LONRF1 RNF19B	8.78e-04	326	43	5	IPR001841
Domain	EPHD	G2E3 RAI1	1.16e-03	22	43	2	PS51805
Domain	CT	MUC5B MUC2	1.16e-03	22	43	2	SM00041
Domain	Cys_knot_C	MUC5B MUC2	1.50e-03	25	43	2	IPR006207
Domain	CTCK_2	MUC5B MUC2	1.50e-03	25	43	2	PS01225
Domain	FYVE	FGD2 FGD4	2.02e-03	29	43	2	PF01363
Domain	FYVE	FGD2 FGD4	2.02e-03	29	43	2	SM00064
Domain	Znf_FYVE-rel	FGD2 FGD4	2.77e-03	34	43	2	IPR017455
Domain	VWFC_1	MUC5B MUC2	3.10e-03	36	43	2	PS01208
Domain	VWC	MUC5B MUC2	3.45e-03	38	43	2	SM00214
Domain	Znf_FYVE	FGD2 FGD4	3.45e-03	38	43	2	IPR000306
Domain	VWFC_2	MUC5B MUC2	3.45e-03	38	43	2	PS50184
Domain	-	CDK5R1 CDK5R2	3.82e-03	40	43	2	1.10.472.10
Domain	ZF_FYVE	FGD2 FGD4	3.82e-03	40	43	2	PS50178
Domain	VWF_dom	MUC5B MUC2	4.20e-03	42	43	2	IPR001007
Domain	Cyclin-like	CDK5R1 CDK5R2	4.40e-03	43	43	2	IPR013763
Domain	ZF_RING_1	RNF39 TRIM47 LONRF1 RNF19B	4.42e-03	291	43	4	PS00518
Domain	Znf_FYVE_PHD	G2E3 FGD2 FGD4	4.68e-03	147	43	3	IPR011011
Domain	ZF_RING_2	RNF39 TRIM47 LONRF1 RNF19B	4.81e-03	298	43	4	PS50089
Domain	PRY	RNF39 TRIM47	5.46e-03	48	43	2	SM00589
Domain	PRY	RNF39 TRIM47	5.46e-03	48	43	2	IPR006574
Domain	Znf_RING_CS	RNF39 TRIM47 LONRF1	6.24e-03	163	43	3	IPR017907
Domain	Znf_C3HC4_RING-type	RNF39 TRIM47 LONRF1	7.23e-03	172	43	3	IPR018957
Domain	RhoGEF	FGD2 FGD4	1.07e-02	68	43	2	SM00325
Domain	BBOX	TRIM47 TRIM44	1.10e-02	69	43	2	SM00336
Domain	Butyrophylin	RNF39 TRIM47	1.13e-02	70	43	2	IPR003879
Domain	DH_2	FGD2 FGD4	1.13e-02	70	43	2	PS50010
Domain	RhoGEF	FGD2 FGD4	1.13e-02	70	43	2	PF00621
Domain	DH-domain	FGD2 FGD4	1.16e-02	71	43	2	IPR000219
Domain	-	FGD2 FGD4	1.16e-02	71	43	2	1.20.900.10
Domain	-	TRIM47 TRIM44	1.16e-02	71	43	2	4.10.45.10
Domain	zf-B_box	TRIM47 TRIM44	1.20e-02	72	43	2	PF00643
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-7 ERVK-10 ERVK-24	8.65e-09	4	46	3	10469592
Pubmed	Expression of Pla2g2a prevents carcinogenesis in Muc2-deficient mice.	PLA2G2A MUC2	1.71e-06	2	46	2	19037975
Pubmed	Membrane association facilitates degradation and cleavage of the cyclin-dependent kinase 5 activators p35 and p39.	CDK5R1 CDK5R2	1.71e-06	2	46	2	20518484
Pubmed	[Interleukin-1beta induces MUC2/MUC5B gene expression in human nasal epithelial cells].	MUC5B MUC2	1.71e-06	2	46	2	20873538
Pubmed	An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator.	CDK5R1 CDK5R2	1.71e-06	2	46	2	7592934
Pubmed	Cyclin-dependent kinase 5 activators p35 and p39 facilitate formation of functional synapses.	CDK5R1 CDK5R2	1.71e-06	2	46	2	15908038
Pubmed	Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes.	CDK5R1 CDK5R2	1.71e-06	2	46	2	18507738
Pubmed	Molecular cloning and characterisation of a mouse gene encoding an isoform of the neuronal cyclin-dependent kinase 5 (CDK5) activator.	CDK5R1 CDK5R2	1.71e-06	2	46	2	9655938
Pubmed	Phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5.	CDK5R1 CDK5R2	5.13e-06	3	46	2	24872417
Pubmed	Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease.	CDK5R1 CDK5R2	5.13e-06	3	46	2	15917097
Pubmed	Cyclin-Dependent Kinase 5 Regulates Dendritic Spine Formation and Maintenance of Cortical Neuron in the Mouse Brain.	CDK5R1 CDK5R2	5.13e-06	3	46	2	25404468
Pubmed	CDK5 regulates cell adhesion and migration in corneal epithelial cells.	CDK5R1 CDK5R2	5.13e-06	3	46	2	12496365
Pubmed	Cdk5 is essential for adult hippocampal neurogenesis.	CDK5R1 CDK5R2	5.13e-06	3	46	2	19017796
Pubmed	Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators.	CDK5R1 CDK5R2	5.13e-06	3	46	2	24085300
Pubmed	Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29.	CDK5R1 CDK5R2	5.13e-06	3	46	2	11784720
Pubmed	Preferential targeting of p39-activated Cdk5 to Rac1-induced lamellipodia.	CDK5R1 CDK5R2	5.13e-06	3	46	2	24877974
Pubmed	Mucin gene polymorphisms in otitis media patients.	MUC5B MUC2	5.13e-06	3	46	2	19718741
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-5 ERVK-7 ERVK-10 ERVK-24	7.48e-06	94	46	4	21542922
Pubmed	Polymorphisms in MUC1, MUC2, MUC5B and MUC6 genes are not associated with the risk of chronic atrophic gastritis.	MUC5B MUC2	1.03e-05	4	46	2	21596555
Pubmed	Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis.	CDK5R1 CDK5R2	1.03e-05	4	46	2	15123626
Pubmed	Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype.	MUC5B MUC2	1.03e-05	4	46	2	23807779
Pubmed	Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H.	FGD2 FGD4	1.03e-05	4	46	2	17564959
Pubmed	The Activators of Cyclin-Dependent Kinase 5 p35 and p39 Are Essential for Oligodendrocyte Maturation, Process Formation, and Myelination.	CDK5R1 CDK5R2	1.03e-05	4	46	2	26961956
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-5 ERVK-10	1.03e-05	4	46	2	7983737
Pubmed	Increased expression of MUC5AC and MUC5B promoting bacterial biofilm formation in chronic rhinosinusitis patients.	MUC5B MUC2	1.03e-05	4	46	2	25638393
Pubmed	Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells.	MUC5B MUC2	1.03e-05	4	46	2	17471237
Pubmed	Expression of MUC1, MUC2, MUC5AC and MUC5B in mucinous lesions of the breast.	MUC5B MUC2	1.03e-05	4	46	2	22269464
Pubmed	The mouse secreted gel-forming mucin gene cluster.	MUC5B MUC2	1.03e-05	4	46	2	14984930
Pubmed	p39-associated Cdk5 activity regulates dendritic morphogenesis.	CDK5R1 CDK5R2	1.03e-05	4	46	2	33127972
Pubmed	Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse.	MUC5B MUC2	1.03e-05	4	46	2	12676567
Pubmed	Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells.	MUC5B MUC2	1.03e-05	4	46	2	29869461
Pubmed	The TGF-beta response to Leishmania chagasi in the absence of IL-12.	CDK5R1 CDK5R2	1.71e-05	5	46	2	12516540
Pubmed	Polymorphism of human mucin genes in chest disease: possible significance of MUC2.	MUC5B MUC2	1.71e-05	5	46	2	11062147
Pubmed	Gut commensal bacteria and regional Wnt gene expression in the proximal versus distal colon.	FZD3 WNT11	1.71e-05	5	46	2	24418259
Pubmed	Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission.	CDK5R1 CDK5R2	1.71e-05	5	46	2	14985430
Pubmed	TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles.	TNFRSF19 FZD3	1.71e-05	5	46	2	10764796
Pubmed	The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner.	CDK5R1 CDK5R2	1.71e-05	5	46	2	12223541
Pubmed	Differential expression of MUC genes in endometrial and cervical tissues and tumors.	MUC5B MUC2	1.71e-05	5	46	2	16188033
Pubmed	Comprehensive glycomics comparison between colon cancer cell cultures and tumours: implications for biomarker studies.	MUC5B MUC2	1.71e-05	5	46	2	24840470
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-5 ERVK-7	1.71e-05	5	46	2	11401426
Pubmed	Cdk5 phosphorylates a component of the HDAC complex and regulates histone acetylation during neuronal cell death.	CDK5R1 CDK5R2	2.56e-05	6	46	2	22398430
Pubmed	Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.	MUC5B MUC2	2.56e-05	6	46	2	19110483
Pubmed	Microtubule association of the neuronal p35 activator of Cdk5.	CDK5R1 CDK5R2	2.56e-05	6	46	2	17491008
Pubmed	Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.	TNFRSF19 FZD3 WNT11	3.37e-05	47	46	3	28813421
Pubmed	Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4.	DEFA5 MUC2	3.58e-05	7	46	2	21125297
Pubmed	Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain.	CDK5R1 CDK5R2	3.58e-05	7	46	2	11226314
Pubmed	p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.	CDK5R1 CDK5R2	4.77e-05	8	46	2	11517264
Pubmed	Cdk5 is required for the positioning and survival of GABAergic neurons in developing mouse striatum.	CDK5R1 CDK5R2	7.65e-05	10	46	2	27480591
Pubmed	Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex.	FZD3 WNT11	9.34e-05	11	46	2	18606138
Pubmed	Role of heat-shock factor 2 in cerebral cortex formation and as a regulator of p35 expression.	CDK5R1 CDK5R2	1.12e-04	12	46	2	16600913
Pubmed	Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2.	EPHB4 CDK5R1	2.03e-04	16	46	2	26027726
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-10 ERVK-24	2.58e-04	18	46	2	18664271
Pubmed	Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.	MUC5B MUC2	2.58e-04	18	46	2	18834073
Pubmed	Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting.	EPHB4 MUC5B	2.88e-04	19	46	2	35294885
Pubmed	Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.	FZD3 WNT11	2.88e-04	19	46	2	21623369
Pubmed	Transcriptional regulation of cortical neuron migration by POU domain factors.	CDK5R1 CDK5R2	3.20e-04	20	46	2	11859196
Pubmed	Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina.	FZD3 WNT11	3.89e-04	22	46	2	12815618
Pubmed	Tbr1 regulates differentiation of the preplate and layer 6.	CDK5R1 CDK5R2	4.25e-04	23	46	2	11239428
Pubmed	LGR5 controls extracellular matrix production by stem cells in the developing intestine.	DEFA5 TNFRSF19	4.25e-04	23	46	2	32468660
Pubmed	Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome.	VN1R2 DEFA5	5.04e-04	25	46	2	20003482
Pubmed	Induction of Gastric Cancer by Successive Oncogenic Activation in the Corpus.	TNFRSF19 MUC2	5.04e-04	25	46	2	34391772
Pubmed	Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections.	FZD3 WNT11	5.88e-04	27	46	2	17804636
Pubmed	3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).	FZD3 WNT11	6.79e-04	29	46	2	18364260
Pubmed	NOTCH maintains developmental cardiac gene network through WNT5A.	EPHB4 WNT11	8.28e-04	32	46	2	30347193
Pubmed	WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis.	FZD3 WNT11	9.90e-04	35	46	2	30940800
Pubmed	Dual regulation of planar polarization by secreted Wnts and Vangl2 in the developing mouse cochlea.	FZD3 WNT11	9.90e-04	35	46	2	32907846
Pubmed	Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation.	FZD3 WNT11	1.05e-03	36	46	2	12412008
Pubmed	Hox5 Genes Regulate the Wnt2/2b-Bmp4-Signaling Axis during Lung Development.	FZD3 WNT11	1.05e-03	36	46	2	26235626
Pubmed	Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.	FZD3 WNT11	1.05e-03	36	46	2	24151333
Pubmed	Integrated analysis of Wnt signalling system component gene expression.	FZD3 WNT11	1.11e-03	37	46	2	35831952
Pubmed	Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis.	FZD3 WNT11	1.11e-03	37	46	2	15342465
Pubmed	A complex oscillating network of signaling genes underlies the mouse segmentation clock.	TNFRSF19 GFRA2	1.11e-03	37	46	2	17095659
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	FGD2 FGD4	1.17e-03	38	46	2	11756498
Pubmed	Tissue-specific requirements of beta-catenin in external genitalia development.	FZD3 WNT11	1.17e-03	38	46	2	18635608
Pubmed	Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals.	FZD3 WNT11	1.17e-03	38	46	2	21041481
GeneFamily	Ring finger proteins	RNF39 TRIM47 TRIM44 LONRF1 RNF19B	9.65e-05	275	31	5	58
GeneFamily	CD molecules\|Mucins	MUC5B MUC2	5.85e-04	21	31	2	648
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	FGD2 FGD4	1.28e-03	31	31	2	81
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	FGD2 FGD4	5.70e-03	66	31	2	722
GeneFamily	Sterile alpha motif domain containing	EPHB4 TNKS2	9.94e-03	88	31	2	760
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM47 TRIM44	1.15e-02	95	31	2	59
Coexpression	BUSSLINGER_DUODENAL_PANETH_CELLS	DEFA5 PLA2G2A MUC2	1.72e-06	15	42	3	M40030
Coexpression	GSE5679_CTRL_VS_PPARG_LIGAND_ROSIGLITAZONE_TREATED_DC_DN	FCSK ZC3H7A PLAGL1 CLCN2 RAI1	1.66e-05	200	42	5	M6554
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#1_top-relative-expression-ranked_1000	CDK5R1 FAM193A TNKS2 TRIM44 GFRA2	4.95e-05	209	41	5	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_1000_k1
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#3_top-relative-expression-ranked_1000	PLAGL1 TNFRSF19 FAM193A TNKS2 FGD4 TRIM44	7.11e-05	369	41	6	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k3_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_500	TNFRSF19 CDK5R1 FAM193A TNKS2 TRIM44 GFRA2	1.22e-04	407	41	6	gudmap_developingLowerUrinaryTract_e14.5_ urethra_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_top-relative-expression-ranked_1000	PLAGL1 TNFRSF19 CDK5R1 FAM193A TNKS2 FGD4 TRIM44 GFRA2	1.31e-04	806	41	8	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_1000	PLAGL1 TNFRSF19 CDK5R1 FAM193A TNKS2 CSRNP2 TRIM44 GFRA2	1.31e-04	806	41	8	gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_top-relative-expression-ranked_1000	PLAGL1 TNFRSF19 CDK5R1 FAM193A TNKS2 TRIM44 GFRA2 DGKK	1.45e-04	818	41	8	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#5_top-relative-expression-ranked_500	CDK5R1 FAM193A TNKS2 TRIM44	1.93e-04	149	41	4	gudmap_developingLowerUrinaryTract_e14.5_ urethra_500_k5
CoexpressionAtlas	dev gonad_e12.5_M_SertoliCell_Sox9_top-relative-expression-ranked_1000	CLCN2 RREB1 TRIM47 FZD3 FGD4 CNMD RNF19B TTYH2	2.46e-04	884	41	8	gudmap_dev gonad_e12.5_M_SertoliCell_Sox9_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#2_top-relative-expression-ranked_1000	PLAGL1 TNFRSF19 FAM193A TNKS2 TRIM44	3.22e-04	312	41	5	gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000_k2
CoexpressionAtlas	AravindRamakr_StemCell-HD_top-relative-expression-ranked_500	DEFA5 PLA2G2A MUC2 FBN3 CNMD DGKK	3.28e-04	489	41	6	Arv_SC-HD_500
CoexpressionAtlas	AravindRamakr_StemCell_from_inducedPluripotentialStemCells_derived from_from_fibroblast_top-relative-expression-ranked_500	DEFA5 PLA2G2A MUC2 FBN3 CNMD DGKK	3.28e-04	489	41	6	Arv_SC_fibroblast_500
CoexpressionAtlas	AravindRamakr_StemCell-H9hpx_top-relative-expression-ranked_500	DEFA5 PLA2G2A MUC2 FBN3 CNMD DGKK	3.39e-04	492	41	6	Arv_SC-H9hpx_500
CoexpressionAtlas	AravindRamakr_StemCell-hypoxiaGrown_fromBlastocyst-derived-humanEmbryonicStemCells_top-relative-expression-ranked_500	DEFA5 PLA2G2A MUC2 FBN3 CNMD DGKK	3.39e-04	492	41	6	Arv_SC-hpx_blastocyst_500
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2-Airway\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TNFRSF19 CHADL RNF39 DGKK	5.67e-06	124	42	4	d88bce8a4f023d5b617b2e8e372a94bd1248d20d
Disease	Charcot-Marie-Tooth disease type 4H (implicated_via_orthology)	FGD2 FGD4	1.02e-05	4	39	2	DOID:0110192 (implicated_via_orthology)
Disease	X-linked Aarskog syndrome (implicated_via_orthology)	FGD2 FGD4	1.02e-05	4	39	2	DOID:6683 (implicated_via_orthology)
Disease	HWESASXX measurement	RREB1 CNMD	3.56e-05	7	39	2	EFO_0021147
Disease	allergic conjunctivitis (is_marker_for)	PLA2G2A MUC2	7.61e-05	10	39	2	DOID:11204 (is_marker_for)
Disease	cholangiocarcinoma (is_marker_for)	MUC5B RNF39 MUC2	8.41e-05	64	39	3	DOID:4947 (is_marker_for)
Disease	Charcot-Marie-Tooth disease (implicated_via_orthology)	FGD2 FGD4	4.61e-04	24	39	2	DOID:10595 (implicated_via_orthology)
Disease	primary biliary cholangitis (is_marker_for)	HAMP MUC2	5.01e-04	25	39	2	DOID:12236 (is_marker_for)
Disease	lissencephaly (implicated_via_orthology)	CDK5R1 CDK5R2	5.85e-04	27	39	2	DOID:0050453 (implicated_via_orthology)
Disease	testosterone measurement	ZC3H7A PLAGL1 TNKS2 RREB1 GFRA2 DGKK RAI1	1.26e-03	1275	39	7	EFO_0004908
Disease	monocyte count	DEFA5 PLAGL1 RREB1 FGD2 FGD4 GFRA2 RAI1	1.54e-03	1320	39	7	EFO_0005091
Disease	cystic fibrosis (is_marker_for)	MUC5B MUC2	3.06e-03	62	39	2	DOID:1485 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLRCLGEFLCRRCYR	CDK5R1	151	Q15078
IRLSREECGCDCRLY	CSRNP2	206	Q9H175
HYTRRQCCCDRGRCW	FBN3	311	Q75N90
LLRCLGDFVCRRCYR	CDK5R2	186	Q13319
NYRRRCACDDCSLSH	FAM193A	206	P78312
YRIRVLCCSDDHCRG	MUC5B	1591	Q9HC84
LSRRLQSCYCCDGRE	RAI1	1776	Q7Z5J4
DRCCVTHDCCYKRLE	PLA2G2A	61	P14555
ECLTRHSYRECLGRL	RB1CC1	206	Q8TDY2
CRRRFSKECCFRSHR	DGKK	441	Q5KSL6
GREDLTYALRCRECR	EPHB4	351	P54760
VPCGHSYCRRCLRRE	LONRF1	136	Q17RB8
QEERCVCRDGRLHCR	MUC2	736	Q02817
TRRRHHCRACGYVVC	FGD4	576	Q96M96
NVGHCRRRCLDTERY	DEFB125	31	Q8N687
RLACETRYVARKCGC	ASIC3	316	Q9UHC3
DCYCVCVERSRHRRL	ERVK-5	56	P61583
DCYCVCVERSRHGRL	ERVK-7	56	P61582
ARATCYCRTGRCATR	DEFA5	61	Q01523
DCYCVCVERSRHRRL	ERVK-24	56	P61581
VCRCLADLRDYCQPH	FCSK	776	Q8N0W3
LLQHYERCDVRRCRC	G2E3	226	Q7L622
CLDLRGVCRTDHLCR	GFRA2	251	O00451
RRRHHCRACGYVVCA	FGD2	476	Q7Z6J4
TLPCRRLCQRAYSEC	FZD3	96	Q9NPG1
ACICDNSRRHVACRY	CHADL	36	Q6NUI6
EVCRECGFCYCRRHA	TRIM44	31	Q96DX7
RYCRAERVCLCEACA	TRIM47	191	Q96LD4
CERCFYTRKDVRRHL	PLAGL1	161	Q9UM63
SCPHRSCRDCLRHYL	RNF19B	136	Q6ZMZ0
SCRDCLRHYLRLEIS	RNF19B	141	Q6ZMZ0
NCYCVCVERSRHRRL	ERVK-10	56	P61580
LLEYGRSRCARCRVC	CLCN2	61	P51788
LDHEGICCIECRRSY	CNMD	276	O75829
RCDICCVTFRTHRGL	RREB1	236	Q92766
IFLVAYLVCACHCRR	TTYH2	61	Q9BSA4
YLVCACHCRRDDAVQ	TTYH2	66	Q9BSA4
DRSCYICHRQLLFCR	TNKS2	1086	Q9H2K2
QLDLCRHEVRYGCLR	ZC3H7A	631	Q8IWR0
LHEYAHRACCQCRRD	TNFRSF19	226	Q9NS68
CCYVTCRRCERTVER	WNT11	336	O96014
LRLHRGEARYLCVDC	ZNF526	351	Q8TF50
RRCYPLAGHLLCRRC	WTIP	396	A6NIX2
INCCCDRDCYLLHPR	TCTN3	101	Q6NUS6
LILFSCCCAFRHRRA	WBP1	66	Q96G27
LACEHSFCRACLARR	RNF39	101	Q9H2S5
RLCSICCRRNRRFFH	VN1R2	376	Q8NFZ6
RRRRDTHFPICIFCC	HAMP	56	P81172