Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	pre-mRNA 3'-splice site binding	ZRSR2P1 ZRSR2	1.79e-04	7	59	2	GO:0030628
GeneOntologyCellularComponent	U2AF complex	ZRSR2P1 ZRSR2	1.63e-04	7	59	2	GO:0089701
GeneOntologyCellularComponent	early endosome	HAVCR2 WDR91 TMEM184A CFTR CLN6 ACKR2 INPP5F	3.97e-04	481	59	7	GO:0005769
Domain	U2AF_small	ZRSR2P1 ZRSR2	9.10e-05	5	57	2	IPR009145
Domain	Atg8	GABARAPL1 GABARAP	2.53e-04	8	57	2	PF02991
Domain	Atg8-like	GABARAPL1 GABARAP	2.53e-04	8	57	2	IPR004241
Domain	A2M_N	A2M PZP	4.05e-04	10	57	2	PF01835
Domain	A2M_N	A2M PZP	4.05e-04	10	57	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	A2M PZP	4.05e-04	10	57	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	A2M PZP	4.05e-04	10	57	2	PS00477
Domain	A2M	A2M PZP	4.05e-04	10	57	2	PF00207
Domain	A2M_N_2	A2M PZP	4.05e-04	10	57	2	IPR011625
Domain	A2M_comp	A2M PZP	4.05e-04	10	57	2	IPR011626
Domain	A2M_N_2	A2M PZP	4.05e-04	10	57	2	PF07703
Domain	A2M_recep	A2M PZP	4.05e-04	10	57	2	PF07677
Domain	A2M_comp	A2M PZP	4.05e-04	10	57	2	PF07678
Domain	Macroglobln_a2	A2M PZP	4.05e-04	10	57	2	IPR001599
Domain	Terpenoid_cyclase/PrenylTrfase	A2M PZP	1.36e-03	18	57	2	IPR008930
Domain	fn3	COL7A1 FNDC1 IL20RB EPHA7	1.51e-03	162	57	4	PF00041
Domain	FN3	COL7A1 FNDC1 IL20RB EPHA7	2.44e-03	185	57	4	SM00060
Domain	FN3	COL7A1 FNDC1 IL20RB EPHA7	3.18e-03	199	57	4	PS50853
Domain	FN3_dom	COL7A1 FNDC1 IL20RB EPHA7	3.79e-03	209	57	4	IPR003961
Pubmed	ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells.	ZRSR2P1 ZRSR2	2.83e-06	2	59	2	33691379
Pubmed	A genetic polymorphism in a functional domain of human pregnancy zone protein: the bait region. Genomic structure of the bait domains of human pregnancy zone protein and alpha 2 macroglobulin.	A2M PZP	2.83e-06	2	59	2	1692292
Pubmed	Zrsr2 and functional U12-dependent spliceosome are necessary for follicular development.	ZRSR2P1 ZRSR2	2.83e-06	2	59	2	35198906
Pubmed	Expression of gec1/GABARAPL1 versus GABARAP mRNAs in human: predominance of gec1/GABARAPL1 in the central nervous system.	GABARAPL1 GABARAP	2.83e-06	2	59	2	14625090
Pubmed	Differential binding properties of human pregnancy zone protein- and alpha2-macroglobulin-proteinase complexes to low-density lipoprotein receptor-related protein.	A2M PZP	2.83e-06	2	59	2	11811950
Pubmed	Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1.	ZRSR2P1 ZRSR2	8.48e-06	3	59	2	8586425
Pubmed	Direct binding to GABARAP family members is essential for HIV-1 Nef plasma membrane localization.	GABARAPL1 GABARAP	8.48e-06	3	59	2	28729737
Pubmed	Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic neoplasm in mice.	ZRSR2P1 ZRSR2	8.48e-06	3	59	2	36030305
Pubmed	Effects of C-terminal modifications of GEC1 protein and gamma-aminobutyric acid type A (GABA(A)) receptor-associated protein (GABARAP), two microtubule-associated proteins, on kappa opioid receptor expression.	GABARAPL1 GABARAP	8.48e-06	3	59	2	21388957
Pubmed	GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton.	GABARAPL1 GABARAP	8.48e-06	3	59	2	9892355
Pubmed	Lack of GABARAP-Type Proteins Is Accompanied by Altered Golgi Morphology and Surfaceome Composition.	GABARAPL1 GABARAP	8.48e-06	3	59	2	33374830
Pubmed	Arginine68 is an essential residue for the C-terminal cleavage of human Atg8 family proteins.	GABARAPL1 GABARAP	8.48e-06	3	59	2	23721406
Pubmed	Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism.	GABARAPL1 GABARAP	8.48e-06	3	59	2	20810658
Pubmed	Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin.	A2M PZP	8.48e-06	3	59	2	12183561
Pubmed	Alpha-2 macroglobulin controls trophoblast positioning in mouse implantation sites.	A2M PZP	8.48e-06	3	59	2	14580373
Pubmed	Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways.	HAVCR2 CFTR	8.48e-06	3	59	2	21263071
Pubmed	Activated human plasma carboxypeptidase B is retained in the blood by binding to alpha2-macroglobulin and pregnancy zone protein.	A2M PZP	8.48e-06	3	59	2	8662763
Pubmed	alpha2-macroglobulin- and murinoglobulin-1- deficient mice. A mouse model for acute pancreatitis.	A2M PZP	8.48e-06	3	59	2	10487856
Pubmed	METTL3 promotes hyperoxia-induced pyroptosis in neonatal bronchopulmonary dysplasia by inhibiting ATG8-mediated autophagy.	GABARAPL1 GABARAP	8.48e-06	3	59	2	37478627
Pubmed	Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.	TBC1D19 GABARAPL1 GABARAP	1.32e-05	27	59	3	22354992
Pubmed	Interaction of matrix metalloproteinases-2 and -9 with pregnancy zone protein and alpha2-macroglobulin.	A2M PZP	1.69e-05	4	59	2	9344465
Pubmed	Pharmacokinetic and Pharmacodynamic Investigations of ION-353382, a Model Antisense Oligonucleotide: Using Alpha-2-Macroglobulin and Murinoglobulin Double-Knockout Mice.	A2M PZP	1.69e-05	4	59	2	27031383
Pubmed	Mouse U2af1-rs1 is a neomorphic imprinted gene.	ZRSR2P1 ZRSR2	1.69e-05	4	59	2	9001233
Pubmed	PX-RICS mediates ER-to-Golgi transport of the N-cadherin/beta-catenin complex.	GABARAPL1 GABARAP	1.69e-05	4	59	2	18451111
Pubmed	Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein.	GABARAPL1 GABARAP	1.69e-05	4	59	2	11414770
Pubmed	Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs.	GABARAPL1 GABARAP	1.69e-05	4	59	2	30767700
Pubmed	Rare functional genetic variants in COL7A1, COL6A5, COL1A2 and COL5A2 frequently occur in Chiari Malformation Type 1.	COL7A1 COL6A5	1.69e-05	4	59	2	33974636
Pubmed	Cloning and mapping of the U2af1-rs2 gene with a high transmission distortion in interspecific backcross progeny.	ZRSR2P1 ZRSR2	1.69e-05	4	59	2	7558001
Pubmed	Enzymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase inhibitors.	A2M PZP	1.69e-05	4	59	2	1702714
Pubmed	The protein interaction landscape of the human CMGC kinase group.	A2M GABARAPL1 ZRSR2 ARHGAP12 GABARAP DIDO1 NEB CNOT3	2.21e-05	695	59	8	23602568
Pubmed	Distribution of mRNA coding for alpha-2-macroglobulin, the murinoglobulins, the alpha-2-macroglobulin receptor and the alpha-2-macroglobulin receptor associated protein during mouse embryogenesis and in adult tissues.	A2M PZP	2.82e-05	5	59	2	7514554
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	A2M ZRSR2P1 ZRSR2 TAF1A EMD EPHA7	3.51e-05	363	59	6	14691545
Pubmed	Nix, a receptor protein for mitophagy in mammals.	GABARAPL1 GABARAP	4.23e-05	6	59	2	20200478
Pubmed	p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.	GABARAPL1 GABARAP	4.23e-05	6	59	2	17580304
Pubmed	A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy.	GABARAPL1 GABARAP	4.23e-05	6	59	2	32315611
Pubmed	Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3.	GABARAPL1 GABARAP	4.23e-05	6	59	2	24747438
Pubmed	MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins.	GABARAPL1 GABARAP	4.23e-05	6	59	2	22948227
Pubmed	Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition.	ZRSR2P1 ZRSR2	4.23e-05	6	59	2	33846634
Pubmed	An ALS-associated variant of the autophagy receptor SQSTM1/p62 reprograms binding selectivity toward the autophagy-related hATG8 proteins.	GABARAPL1 GABARAP	5.91e-05	7	59	2	34929165
Pubmed	Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.	GABARAPL1 GABARAP	5.91e-05	7	59	2	24668264
Pubmed	A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA.	ZRSR2P1 ZRSR2	5.91e-05	7	59	2	9237760
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	A2M MEGF8 ENTPD5 PZP F8	7.66e-05	257	59	5	16335952
Pubmed	Autophagy receptor NDP52 regulates pathogen-containing autophagosome maturation.	GABARAPL1 GABARAP	7.87e-05	8	59	2	25771791
Pubmed	Allelic variants between mouse substrains BALB/cJ and BALB/cByJ influence mononuclear cardiomyocyte composition and cardiomyocyte nuclear ploidy.	ZRSR2P1 ZRSR2	7.87e-05	8	59	2	32371981
Pubmed	DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription.	GABARAPL1 GABARAP	7.87e-05	8	59	2	22470510
Pubmed	A screen for retrotransposed imprinted genes reveals an association between X chromosome homology and maternal germ-line methylation.	ZRSR2 NAP1L2	7.87e-05	8	59	2	17291163
Pubmed	TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1.	GABARAPL1 GABARAP	7.87e-05	8	59	2	31685529
Pubmed	Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.	GABARAPL1 GABARAP	7.87e-05	8	59	2	28604719
Pubmed	Mass spectrometry proteomics reveals a function for mammalian CALCOCO1 in MTOR-regulated selective autophagy.	GABARAPL1 GABARAP	7.87e-05	8	59	2	31971854
Pubmed	Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins.	GABARAPL1 GABARAP	1.01e-04	9	59	2	29867141
Pubmed	Targeted inactivation of the mouse alpha 2-macroglobulin gene.	A2M PZP	1.01e-04	9	59	2	7544347
Pubmed	Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth.	GABARAPL1 GABARAP	1.01e-04	9	59	2	21617041
Pubmed	Regulation of endoplasmic reticulum turnover by selective autophagy.	GABARAPL1 GABARAP	1.01e-04	9	59	2	26040720
Pubmed	Sak kinase gene structure and transcriptional regulation.	LYST PLK4	1.01e-04	9	59	2	10607900
Pubmed	The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.	GABARAPL1 GABARAP	1.01e-04	9	59	2	29251248
Pubmed	Nix is a selective autophagy receptor for mitochondrial clearance.	GABARAPL1 GABARAP	1.26e-04	10	59	2	20010802
Pubmed	A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.	GABARAPL1 GABARAP	1.26e-04	10	59	2	19250911
Pubmed	SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation.	GABARAPL1 GABARAP	1.26e-04	10	59	2	31213539
Pubmed	HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα.	GABARAPL1 GABARAP	1.26e-04	10	59	2	30217973
Pubmed	Transcriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesis.	A2M HAVCR2	1.26e-04	10	59	2	21858045
Pubmed	ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8.	GABARAPL1 GABARAP	1.26e-04	10	59	2	28287329
Pubmed	The IAP family member BRUCE regulates autophagosome-lysosome fusion.	GABARAPL1 GABARAP	1.26e-04	10	59	2	29426817
Pubmed	Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set.	SRPX2 NAP1L2 KRI1 IL20RB	1.50e-04	157	59	4	12466305
Pubmed	The DNA methyltransferase DNMT3A contributes to autophagy long-term memory.	GABARAPL1 GABARAP	1.54e-04	11	59	2	32876528
Pubmed	An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.	A2M PZP	1.54e-04	11	59	2	19105203
Pubmed	ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs.	GABARAPL1 GABARAP	1.54e-04	11	59	2	23043107
Pubmed	Methods for Studying Interactions Between Atg8/LC3/GABARAP and LIR-Containing Proteins.	GABARAPL1 GABARAP	1.54e-04	11	59	2	28253953
Pubmed	CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.	GABARAPL1 GABARAP	1.54e-04	11	59	2	25684205
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	WDR91 GABARAPL1 TMEM184A TAF1A DIDO1 EMD FBXO21 CNOT3	1.62e-04	925	59	8	28986522
Pubmed	The human plasma proteome: a nonredundant list developed by combination of four separate sources.	A2M PZP F8 EPHA7	1.81e-04	165	59	4	14718574
Pubmed	Autophagy is essential for mouse sense of balance.	GABARAPL1 GABARAP	1.85e-04	12	59	2	20577052
Pubmed	Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.	A2M KHDRBS1 DIDO1 EMD F8	2.42e-04	329	59	5	34316702
Pubmed	NIMA-related kinase 9-mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1.	GABARAPL1 GABARAP	2.54e-04	14	59	2	31857374
Pubmed	Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage.	GABARAPL1 GABARAP	2.54e-04	14	59	2	36179369
Pubmed	CCT2 is an aggrephagy receptor for clearance of solid protein aggregates.	GABARAPL1 GABARAP	2.93e-04	15	59	2	35366418
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	GABARAPL1 TMEM184A MEGF8 CLN6 KRI1 EMD KLHDC4 NT5DC3	3.16e-04	1021	59	8	26760575
Pubmed	Comparative mapping of the imprinted U2afbpL gene on mouse chromosome 11 and human chromosome 5.	ZRSR2P1 ZRSR2	3.79e-04	17	59	2	7956352
Pubmed	TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.	GABARAPL1 GABARAP	4.75e-04	19	59	2	26347139
Pubmed	TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.	GABARAPL1 GABARAP	5.27e-04	20	59	2	25127057
Pubmed	Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum.	GABARAPL1 GABARAP	6.39e-04	22	59	2	37225996
Pubmed	Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex.	KHDRBS1 CNOT3	6.39e-04	22	59	2	18377426
Pubmed	Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle.	MEGF8 EMD	1.04e-03	28	59	2	28655764
Pubmed	Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development.	KHDRBS1 ARHGAP12	1.04e-03	28	59	2	38324473
Pubmed	Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.	ZRSR2P1 ZRSR2	1.12e-03	29	59	2	32527007
Pubmed	The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II.	KHDRBS1 EMD	1.27e-03	31	59	2	32355176
Pubmed	Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway.	GABARAPL1 GABARAP	1.44e-03	33	59	2	29149599
Pubmed	A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation.	OTUD5 SUV39H1	1.53e-03	34	59	2	10857745
Pubmed	Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.	A2M COL7A1 COL6A5	1.59e-03	135	59	3	28675934
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	A2M PZP	1.53e-04	9	38	2	1234
GeneFamily	Fibronectin type III domain containing	COL7A1 FNDC1 IL20RB EPHA7	3.45e-04	160	38	4	555
GeneFamily	Autophagy related	GABARAPL1 GABARAP	2.18e-03	33	38	2	1022
GeneFamily	Zinc fingers CCCH-type	ZRSR2P1 ZRSR2	2.45e-03	35	38	2	73
GeneFamily	Collagens	COL7A1 COL6A5	4.20e-03	46	38	2	490
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M OTOGL CFTR UNC13C NEB EPHA7	1.62e-07	184	59	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M OTOGL CFTR UNC13C NEB EPHA7	1.62e-07	184	59	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M OTOGL CFTR UNC13C NEB EPHA7	1.62e-07	184	59	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	FLU-Healthy-1\|Healthy / Virus stimulation, Condition and Cluster	HAVCR2 ENTPD5 PZP F8 KNL1	2.22e-06	159	59	5	97c8e16a7ac10ebba96daee97f9fb1d4a404f23b
ToppCell	FLU-Healthy-1\|FLU / Virus stimulation, Condition and Cluster	HAVCR2 ENTPD5 PZP F8 KNL1	2.22e-06	159	59	5	fe2a9f79b058e89214256e736f6e266830cdfa28
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M GABARAPL1 LYST CDC14A EPHA7	5.17e-06	189	59	5	8e583ec4df0f5b79ce5211cc99ecd8616d180bde
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M GABARAPL1 LYST CDC14A EPHA7	5.17e-06	189	59	5	fb2253b8463d08b3d28e952a31a23dea2c2d986b
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-CD4+_CTL\|Int-URO / Disease, condition lineage and cell class	A2M TMEM184A ENTPD5 PZP CDC14A	6.48e-06	198	59	5	717735d755745439f97ba1b71785c73945dfa9c5
ToppCell	Int-URO-Lymphocyte-T_NK-CD4_CTL\|Int-URO / Disease, Lineage and Cell Type	A2M TMEM184A ENTPD5 PZP	5.06e-05	153	59	4	fdc7dfa8f4db90bfdc7180bf178cf6d2dd064d97
ToppCell	10x5'-Lung-Myeloid_Monocytic-Cycling_mono\|Lung / Manually curated celltypes from each tissue	CDC42BPG SUV39H1 PLK4 KNL1	5.46e-05	156	59	4	63b8cf14361b282872bc1c5b65d9fbc83e81a089
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HAVCR2 C1orf54 LYST PLK4	5.73e-05	158	59	4	91d265e95156f16459924d3e4dd11c180e164eee
ToppCell	390C-Myeloid-Dendritic-cDC_proliferating_2\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	TAF1A PLK4 F8 KNL1	6.32e-05	162	59	4	a957c7e347189b72fbd47db3075bb5e879a21c67
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	C1orf54 ENTPD5 KRI1 PLK4	6.47e-05	163	59	4	63b0badaee3b2d827b1f4524510e3384d8f8fcde
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HAVCR2 CDC42BPG DIDO1 KLHDC4	6.47e-05	163	59	4	a24db9d266a40f3bffe4f18d277bc269791b4560
ToppCell	Basal_cells-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	COL7A1 SRPX2 UNC13C NT5DC3	6.94e-05	166	59	4	aea2ae12e4746149ebc6da063ef694381c098f80
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-TRGV4_gdT\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HAVCR2 MEGF8 KRI1 LRRC43	7.61e-05	170	59	4	65c7ed586e7615203a59999549892ed466a89502
ToppCell	facs-Heart-RV-18m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMKLR2 FNDC1 SRPX2 COL6A5	7.61e-05	170	59	4	d7c9a604311974ff87ece43a0f8725a234d262f7
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GABRD FNDC1 PLK4 KNL1	7.79e-05	171	59	4	b0373ed8283ee1792b6a490bff93906546978593
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GABRD FNDC1 PLK4 KNL1	7.79e-05	171	59	4	b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCell	facs-Heart-RV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMKLR2 FNDC1 SRPX2 COL6A5	8.71e-05	176	59	4	c0a084f7a8645262d61971f094689e02bf15b113
ToppCell	facs-Heart-RV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMKLR2 FNDC1 SRPX2 COL6A5	8.71e-05	176	59	4	cccf9201f6e2da7524b911a5961d3b227edab222
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-T_cells-NK_T_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HAVCR2 OTUD5 STARD3NL LRRC43	8.71e-05	176	59	4	dbc4f64cd39b229f2355ca1d0215cc7f6a767dce
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	A2M GABARAPL1 PZP KLHDC4	8.90e-05	177	59	4	84930899eb2978598bc8a351cbcd9e714e46799d
ToppCell	droplet-Lung-30m-Epithelial-alveolar_epithelial\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RGN TMEM184A CFTR EPHA7	9.10e-05	178	59	4	76e71fff99cf64302e2e3c0d66dd8ba0ff13624e
ToppCell	droplet-Lung-30m-Epithelial-alveolar_epithelial-type_II_pneumocyte-type_2_alveolar_epithelial_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RGN TMEM184A CFTR EPHA7	9.10e-05	178	59	4	82f78ea1ea3ff3e2347cd8bc2f06e2a10e96f220
ToppCell	droplet-Lung-30m-Epithelial\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RGN TMEM184A CFTR EPHA7	9.10e-05	178	59	4	5442bc52b8e902da1383f44d97a9f95e471a8d4d
ToppCell	droplet-Lung-30m-Epithelial-alveolar_epithelial-type_II_pneumocyte\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RGN TMEM184A CFTR EPHA7	9.10e-05	178	59	4	523b286ebe0359c7f1902f28cbd71f452626fc0d
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M FNDC1 COL6A5 EPHA7	9.50e-05	180	59	4	f2f6e83127a4a415e65c76a35efa8175fbd5b5d9
ToppCell	facs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC1 SRPX2 COL6A5 CCDC40	9.70e-05	181	59	4	c7f5aedcb74c21fb587a95a16d700e2a38a380ee
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	A2M FNDC1 SRPX2 COL6A5	9.70e-05	181	59	4	c6d2a13df3b74fade3b0c71e285b4c14c8e52413
ToppCell	facs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC1 SRPX2 COL6A5 CCDC40	9.70e-05	181	59	4	0ec9621a078d004bbd25a587757d24b5cf162959
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	A2M FNDC1 SRPX2 COL6A5	9.70e-05	181	59	4	c62b0a2422377ffadaab63edd538e87a06fa5017
ToppCell	normal_Lung-Fibroblasts-Myofibroblasts\|normal_Lung / Location, Cell class and cell subclass	CMKLR2 COL7A1 FNDC1 SRPX2	1.03e-04	184	59	4	0b336489c10e8c3c957795dd845454f03404382b
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_B-B_atypical-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RGN NEB TSPAN3 KNL1	1.06e-04	185	59	4	53960307c6710401c3d52a766c3f4704ace9637f
ToppCell	Control-Endothelial-Endothelial-Vein\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC19A2 CLN6 UNC13C LYST	1.08e-04	186	59	4	92092f11ecce22c14f244e42c499af0822977e6f
ToppCell	droplet-Limb_Muscle-nan-3m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MEGF8 ENTPD5 ASCC2 KRI1	1.15e-04	189	59	4	16a4c92dd7a0d60f3691bd3130a091a9a54730f1
ToppCell	COPD-Lymphoid-T_Cytotoxic\|Lymphoid / Disease state, Lineage and Cell class	A2M GABARAPL1 PZP CDC14A	1.17e-04	190	59	4	10bece40d980d37a01dae8ce887655bf9f93040c
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	A2M TMX3 PARP14 LYST	1.19e-04	191	59	4	9454f642c3621370fa23640b631301346b300950
ToppCell	droplet-Heart-nan-18m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M GABARAPL1 CDC14A EPHA7	1.22e-04	192	59	4	0b9b2eaed45456d7d74ce78a64ef4a26ac2458fb
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Deep_Layer-27\|World / Primary Cells by Cluster	ZRSR2P1 KHDRBS1 GABARAP EPHA7	1.22e-04	192	59	4	cf989f26c0ebdc0cd12e1e41958f063e4fa3e468
ToppCell	metastatic_Brain-Myeloid_cells-Undetermined\|metastatic_Brain / Location, Cell class and cell subclass	A2M HAVCR2 C1orf54 GABARAP	1.24e-04	193	59	4	e7d2833ad48e4db547d046514036948c58c01dde
ToppCell	LAM-Endothelial-LymEndo\|LAM / Condition, Lineage and Cell class	A2M GABRD ACKR2 F8	1.24e-04	193	59	4	68eadc91c2d89edd2412e86dfe134dd7c0ef6ee9
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M GABRD FNDC1 SRPX2	1.24e-04	193	59	4	dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCell	IPF-Lymphoid-T_Cytotoxic\|Lymphoid / Disease state, Lineage and Cell class	A2M GABARAPL1 PZP CDC14A	1.24e-04	193	59	4	3c8a022dbd4f8d25b14fd137ce64c2713a7dbe41
ToppCell	droplet-Tongue-nan-24m-Epithelial-proliferating\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SUV39H1 CLN6 PLK4 KNL1	1.24e-04	193	59	4	f20b90e3f3f5c9a1ae51c5ebe6d3adb954a142f2
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M GABRD FNDC1 SRPX2	1.24e-04	193	59	4	e2ee077fd381bd906e6b4329f22e7d106e422a7f
ToppCell	ASK428-Mesenchymal\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	A2M RGN SRPX2 COL6A5	1.29e-04	195	59	4	2b156163975d9a3d3fda1402acd9831d0fdc9e25
ToppCell	ASK428-Mesenchymal-Fibroblast\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	A2M RGN SRPX2 COL6A5	1.29e-04	195	59	4	c269c0d894a0f55da6495b59d4b9abb9f68df684
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M FNDC1 COL6A5 EPHA7	1.32e-04	196	59	4	2ab9735aa7a7e95dcf6b0bdf0427f7b57f6349ee
ToppCell	droplet-Heart-nan-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M GABARAPL1 CDC14A EPHA7	1.32e-04	196	59	4	e386526332138e636aef2542c11316347a45689c
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TBC1D19 A2M PZP CDC14A	1.34e-04	197	59	4	e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell	distal-mesenchymal-Alveolar_Fibroblast-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	A2M SRPX2 SLC19A2 COL6A5	1.37e-04	198	59	4	7f728ca6d5317890c6fcde3ce6c10c0970d49a05
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-CD8+_T_naive\|Int-URO / Disease, condition lineage and cell class	DENND2C NAP1L2 ASCC2 PLK4	1.37e-04	198	59	4	8c7d00d8c27fb47954d8ac53eebc4582e92b970c
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	A2M HAVCR2 C1orf54 PARP14	1.37e-04	198	59	4	cc808d872d2404a79ec119bb0be62688a30c93a7
ToppCell	ILEUM-inflamed-(8)_Fibroblasts\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	A2M FNDC1 COL6A5 EPHA7	1.40e-04	199	59	4	3a3e2bb21cd0293622b1a975263e918d9ba24265
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	A2M HAVCR2 WDR91 PARP14	1.40e-04	199	59	4	e245851a5bddf56f7e13a7fb7c5fda2fd275dae3
ToppCell	Sigmoid-(5)_Dendritic_cell-(51)_cDC1\|Sigmoid / shred on region, Cell_type, and subtype	GABRD HAVCR2 C1orf54 INPP5F	1.42e-04	200	59	4	4ce0a2238c90622e41fd86ac4b7d82adf4af2c3b
ToppCell	5'-GW_trimst-2-SmallIntestine\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RGN FNDC1 GABARAP TSPAN3	1.42e-04	200	59	4	5bff27963fbfc8d0ce2b6e073fba5121fbe8d5a1
ToppCell	Sigmoid-Dendritic_cell-cDC1\|Sigmoid / Region, Cell class and subclass	GABRD HAVCR2 C1orf54 INPP5F	1.42e-04	200	59	4	3523ec986e8c9e176e08836c974b1de8b56d8b16
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	A2M HAVCR2 WDR91 GABARAP	1.42e-04	200	59	4	74ceebee9af63f8b3ec5857eff1b662752bc3862
ToppCell	Bronchus_Control_(B.)-Immune-TX-DCs\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	A2M HAVCR2 WDR91 C1orf54	1.42e-04	200	59	4	e0beacb88bbdc353a3e883171613027feafcf1ef
Drug	Bethanechol chloride [590-63-6]; Down 200; 20.4uM; HL60; HT_HG-U133A	KHDRBS1 CLN6 DIDO1 INPP5F CDC14A PLK4 F8	7.61e-07	197	59	7	2975_DN
Drug	pyromellitic dianhydride	ACKR2 LYST F8	2.69e-06	11	59	3	CID000006966
Disease	Primary microcephaly	PLK4 KNL1	8.26e-04	22	57	2	C0431350
Disease	Bronchiectasis	CFTR CCDC40	8.26e-04	22	57	2	C0006267

Protein segments in the cluster

Peptide	Gene	Start	Entry
ITYDDYDHFFEDVYT	TSPAN3	36	O60637
DSENSSFYYYDYLDE	ACKR2	16	O00590
SFYYYDYLDEVAFML	ACKR2	21	O00590
SSYYVFYIYVGVADT	CFTR	911	P13569
YFSIDEELVYENFYA	CDC14A	36	Q9UNH5
PYHSVYYEDEYDDTY	ASCC2	606	Q9H1I8
DYYETDEFAIAEYNA	A2M	1451	P01023
TDEFEQGTYIYFDYE	CNOT3	716	O75175
YDYYETDESVVAEYI	PZP	1456	P20742
YYYDYAVEEEEEEEE	NAP1L2	206	Q9ULW6
DSYYDYIWDVTILEY	INTS8	926	Q75QN2
YAFQDEEYLYLVMDY	CDC42BPG	136	Q6DT37
DYESYLEGAVYIDQY	FBXO21	191	O94952
FYAFSYYYDRAVDTD	ENTPD5	326	O75356
YYYDRAVDTDMIDYE	ENTPD5	331	O75356
FLDTECTYDYLFVYD	MEGF8	76	Q7Z7M0
AYANDFASEYYLESE	KNL1	1366	Q8NG31
EEYLDEYYRLDYEDI	KRI1	501	Q8N9T8
EDFFLYIAYSDESVY	GABARAP	101	O95166
DLESYGYSSEDIVYY	GABRD	181	O14764
DYYEDSYEDISAYLL	F8	736	P00451
ETFNLYYYETDYDTG	EPHA7	121	Q15375
YSVEYQGEYESLYTS	IL20RB	66	Q6UXL0
YIEVEYDYEYEAKDR	ARHGAP12	16	Q8IWW6
SLFVAFYDYQAYPEY	PARP14	1781	Q460N5
EDYFLYVAYSDESVY	GABARAPL1	101	Q9H0R8
EAYVIYDEDYEFETS	FNDC1	1556	Q4ZHG4
YSDDTEVEFYITDYS	COL6A5	486	A8TX70
YGDAESEEEYYYTET	CCDC40	86	Q4G0X9
TEEEEVAYISLYSYF	DIDO1	1126	Q9BTC0
YYTQSEDNIYEDIIY	DENND2C	301	Q68D51
EDRYVDTYKYLEEEY	LYST	3201	Q99698
YEEYGYDDTYAEQSY	KHDRBS1	366	Q07666
DYIYYNDVYAFNLDT	KLHDC4	201	Q8TBB5
EYSEYSEYSVEEYQD	COL7A1	2851	Q02388
NDDYYEESYFTTRTY	EMD	91	P50402
ATEIAYYSYIYSVVD	SLC19A2	136	O60779
NSAYYVAYYDDEVDK	INPP5F	646	Q9Y2H2
ITYNYYVTYDFVKDE	LRRC43	336	Q8N309
YYSFDGLEYDYISDC	OTOGL	956	Q3ZCN5
DYFSNYVTEDFTTYI	OTUD5	256	Q96G74
YYVYFDSVRDCYEAF	TMEM184A	116	Q6ZMB5
YMYSYFQTLEDSDSY	TAF1A	76	Q15573
IEIYGFDYDYTLVFY	NT5DC3	96	Q86UY8
VYEVEEPNEYYCYVS	HAVCR2	271	Q8TDQ0
YYIDSLSYSVDAFDY	RGN	166	Q15493
YNYFEDSNYVYLVLE	PLK4	76	O00444
LDYVEDVYTVDAAYY	SUV39H1	301	O43463
ELTQYYFYEYGFDEL	TASOR	296	Q9UK61
GEDEYYQVVYYYTVT	C1orf54	26	Q8WWF1
TLIDSFELLYYYDEY	CLN6	161	Q9NWW5
EFENYSYDLDYYSLE	CMKLR2	11	P46091
LVFKDETYFVYDEYE	TMX3	201	Q96JJ7
DVYTEPYYYKAEDEE	UNC13C	851	Q8NB66
YYPDESYNEVYAEEV	SRPX2	31	O60687
YDYYSSYFDIFLLAV	STARD3NL	91	O95772
EYSEEETYQQFLDFY	ZRSR2P1	231	Q15695
LTASNDDYYFVFEDY	TBC1D19	301	Q8N5T2
DDYYFVFEDYLYQVL	TBC1D19	306	Q8N5T2
EVYSVEFSYDENTVY	WDR91	606	A4D1P6
EYSEEETYQQFLDFY	ZRSR2	226	Q15696
DYEEVVEYYTEEVVY	NEB	6	P20929