Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionTBP-class protein binding

CAND1 CAND2

7.37e-053382GO:0017025
GeneOntologyMolecularFunctiongeneral transcription initiation factor binding

CAND1 CAND2

2.80e-046482GO:0140296
GeneOntologyBiologicalProcessSCF complex assembly

CAND1 CAND2

1.32e-07282GO:0010265
DomainTATA-bd_TIP120

CAND1 CAND2

1.61e-07282IPR013932
DomainTIP120

CAND1 CAND2

1.61e-07282PF08623
DomainHEAT

CAND1 RANBP6 CAND2

8.84e-074883PF02985
Domain-

CAND1 RANBP6 CAND2 ARMCX3

1.31e-06222841.25.10.10
DomainHEAT

CAND1 RANBP6 CAND2

1.57e-065883IPR000357
DomainHEAT_REPEAT

CAND1 RANBP6 CAND2

2.79e-067083PS50077
DomainARM-like

CAND1 RANBP6 CAND2 ARMCX3

2.86e-0627084IPR011989
DomainARM-type_fold

CAND1 RANBP6 CAND2 ARMCX3

7.05e-0633984IPR016024
Domain-

DHX38 YLPM1

3.80e-02746823.40.50.300
Pubmed

TIP120B: a novel TIP120-family protein that is expressed specifically in muscle tissues.

CAND1 CAND2

1.39e-0738210441524
Pubmed

TBP-interacting protein 120B, which is induced in relation to myogenesis, binds to NOT3.

CAND1 CAND2

1.39e-0738212207886
Pubmed

The steady-state repertoire of human SCF ubiquitin ligase complexes does not require ongoing Nedd8 conjugation.

CAND1 CAND2

9.72e-0778221169563
Pubmed

A HECT domain E3 enzyme assembles novel polyubiquitin chains.

CAND1 CAND2

1.30e-0688211278995
Pubmed

Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression.

CAND1 CAND2

3.61e-06138229499133
Pubmed

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.

CAND1 RANBP6 CAND2 ARMCX3

6.04e-066068436538041
Pubmed

Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells.

CAND1 CAND2

1.50e-05268223181366
Pubmed

5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.

RANBP6 CAND2

1.62e-05278223027611
Pubmed

Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.

CAND1 RANBP6 ARMCX3

2.96e-052858332838362
Pubmed

Comprehensive Proteomic Analysis of PGC7-Interacting Proteins.

CAND1 CAND2 ATP1A2

3.02e-052878328712289
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

CAND1 RANBP6 CAND2 ARMCX3

3.91e-059748428675297
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

CAND1 DHX38 YLPM1 PHF14

4.58e-0510148432416067
Pubmed

Novel CUL3 Variant Causing Familial Hyperkalemic Hypertension Impairs Regulation and Function of Ubiquitin Ligase Activity.

CAND1 CAND2

7.34e-05578234878901
Pubmed

Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases.

CAND1 CAND2

8.69e-05628229103612
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

CAND1 PHF14 ARMCX3

1.30e-044698327634302
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

CAND1 DHX38 YLPM1 PHF14

1.31e-0413278432694731
Pubmed

A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development.

CAND1 CAND2

1.72e-04878237495603
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

CAND1 CAND2 ATP1A2

1.85e-045298314621295
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

CAND1 DHX38 RANBP6 ARMCX3

1.87e-0414558422863883
InteractionCLTC interactions

CAND1 DHX38 RANBP6 ATP1A2 ARMCX3

1.84e-0665585int:CLTC
InteractionTNFSF13B interactions

CAND1 RANBP6 CAND2

1.10e-0511983int:TNFSF13B
InteractionRBM3 interactions

CAND1 YLPM1 PHF14

2.82e-0516383int:RBM3
InteractionLRRC17 interactions

RANBP6 ARMCX3

2.88e-052182int:LRRC17
InteractionJMJD6 interactions

CAND1 DHX38 RANBP6

5.59e-0520583int:JMJD6
InteractionCLEC16A interactions

CAND1 RANBP6 CAND2 ARMCX3

5.95e-0562984int:CLEC16A
InteractionTMEM108 interactions

CAND1 CAND2

6.38e-053182int:TMEM108
InteractionSSRP1 interactions

CAND1 DHX38 YLPM1 PHF14

8.30e-0568584int:SSRP1
InteractionDBR1 interactions

CAND1 DHX38

1.07e-044082int:DBR1
InteractionATP1A2 interactions

CAND1 ATP1A2

1.35e-044582int:ATP1A2
InteractionDHX8 interactions

CAND1 DHX38 YLPM1

1.60e-0429283int:DHX8
InteractionFAM177A1 interactions

DHX38 ARMCX3

1.61e-044982int:FAM177A1
InteractionHTR6 interactions

RANBP6 CAND2

2.25e-045882int:HTR6
InteractionPTPN7 interactions

RANBP6 ARMCX3

2.83e-046582int:PTPN7
InteractionKHDRBS1 interactions

CAND1 DHX38 YLPM1

3.29e-0437383int:KHDRBS1
InteractionGNL2 interactions

CAND1 DHX38 RANBP6

3.63e-0438683int:GNL2
InteractionDRG1 interactions

CAND1 CAND2 PHF14

3.69e-0438883int:DRG1
InteractionCHRM3 interactions

RANBP6 CAND2

4.40e-048182int:CHRM3
InteractionIPO5 interactions

CAND1 RANBP6 ARMCX3

4.46e-0441483int:IPO5
InteractionPTPRH interactions

CAND1 CAND2

4.73e-048482int:PTPRH
InteractionRNPS1 interactions

CAND1 DHX38 PHF14

4.82e-0442583int:RNPS1
InteractionSUPT16H interactions

CAND1 DHX38 PHF14

5.41e-0444283int:SUPT16H
InteractionRBMX interactions

CAND1 DHX38 YLPM1

6.11e-0446183int:RBMX
InteractionANKRD50 interactions

YLPM1 ARMCX3

7.80e-0410882int:ANKRD50
InteractionRANBP6 interactions

RANBP6 ARMCX3

8.24e-0411182int:RANBP6
InteractionCCDC59 interactions

RANBP6 ARMCX3

8.39e-0411282int:CCDC59
InteractionSIGLECL1 interactions

RANBP6 CAND2

8.54e-0411382int:SIGLECL1
InteractionARHGAP36 interactions

CAND1 CAND2

8.69e-0411482int:ARHGAP36
InteractionPTPRN interactions

RANBP6 CAND2

9.15e-0411782int:PTPRN
InteractionPTGER3 interactions

CAND2 ARMCX3

9.30e-0411882int:PTGER3
InteractionPACC1 interactions

RANBP6 ARMCX3

9.46e-0411982int:PACC1
InteractionINSIG1 interactions

CAND1 PHF14

1.08e-0312782int:INSIG1
InteractionTACSTD2 interactions

RANBP6 CAND2

1.11e-0312982int:TACSTD2
InteractionHTR2C interactions

CAND1 CAND2

1.13e-0313082int:HTR2C
InteractionPNKD interactions

RANBP6 ARMCX3

1.16e-0313282int:PNKD
InteractionARMCX3 interactions

RANBP6 ARMCX3

1.18e-0313382int:ARMCX3
InteractionPPP4C interactions

CAND1 DHX38

1.34e-0314282int:PPP4C
InteractionTRIM28 interactions

CAND1 DHX38 CAND2 ATP1A2

1.57e-03147484int:TRIM28
InteractionSUZ12 interactions

CAND1 PHF14 ARMCX3

1.61e-0364483int:SUZ12
CoexpressionGSE18791_CTRL_VS_NEWCASTLE_VIRUS_DC_4H_UP

RANBP6 YLPM1 PHF14

2.35e-0519983M4260
CoexpressionERWIN_COHEN_BLOOD_LIVE_VACCINE_TC_83_AGE_23_48YO_VACCINATED_VS_CONTROL_14DY_UP

CAND1 RANBP6 PHF14 ARMCX3

3.01e-0568784M41022
CoexpressionRASHI_RESPONSE_TO_IONIZING_RADIATION_3

CAND1 YLPM1

8.75e-054782MM515
CoexpressionRASHI_RESPONSE_TO_IONIZING_RADIATION_3

CAND1 YLPM1

8.75e-054782M7248
CoexpressionRICKMAN_METASTASIS_UP

CAND1 CAND2 ARMCX3

1.26e-0435083M9752
CoexpressionIVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR

CAND1 YLPM1 PHF14

2.78e-0445883M1606
CoexpressionIVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR

CAND1 YLPM1 PHF14

3.25e-0448383MM1012
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_k-means-cluster#3_top-relative-expression-ranked_1000

CAND1 RANBP6 YLPM1

1.59e-0430783gudmap_developingKidney_e15.5_Peripheral blastema_1000_k3
CoexpressionAtlasDevelopingLowerUrinaryTract_e13.5_bladder mesenchyme_emap-3087_k-means-cluster#4_top-relative-expression-ranked_500

CAND1 RANBP6

2.03e-045882gudmap_developingLowerUrinaryTract_e13.5_bladder mesenchyme_500_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_k-means-cluster#1_top-relative-expression-ranked_1000

CAND1 RANBP6 YLPM1

2.32e-0434983DevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_k1_1000
ToppCellCOVID-19-Heart-CM_5_(RYR2-)|COVID-19 / Disease (COVID-19 only), tissue and cell type

CAND2 ATP1A2

2.81e-0414482f92e03dd784e31a9e5dbd4f4c3a6517ea19210cf
ToppCell10x5'v1-week_12-13-Myeloid_DC-DC-tDC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

CAND2 ATP1A2

3.43e-0415982141c3ed35c7d11fcaec4acd9cb37104cc259db25
ToppCelldroplet-Lung-nan-18m-Lymphocytic-plasma_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAND2 ARMCX3

3.60e-04163825efecdd8a069a822bc9d35b407092925a865e629
ToppCelldroplet-Lung-nan-18m-Lymphocytic-Plasma_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAND2 ARMCX3

3.60e-04163820d94a427f86e62aba12c397c6d7b8cd297f3a0e5
ToppCellTCGA-Colorectal-Solid_Tissue_Normal-Colon_normal_tissue-Colon_normal_tissue-9|TCGA-Colorectal / Sample_Type by Project: Shred V9

CAND2 ATP1A2

3.73e-041668268e6fc7c0040bbe48a93f96ecf28afffdc626845
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAND2 YLPM1

4.10e-0417482f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellPericytes-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

CAND2 ATP1A2

4.29e-0417882a2448d868da2abe48c394c51264aad03e866dfec
ToppCellParenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CAND2 ATP1A2

5.25e-0419782470e23dee4ca35e1fd021b7cdd58fcbc90639837
ToppCellTracheal-10x3prime_v2-Stromal-Schwann|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CAND2 ATP1A2

5.36e-04199828dc65662c3ca1db2ba0091332f0658abc0afc5de
ToppCellTracheal-10x3prime_v2-Stromal-Schwann-Schwann_nonmyelinating|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CAND2 ATP1A2

5.36e-0419982a92718a3f1153b8d2196fd343ed5bc0ebc98cad7
Drug17-AAG; Up 200; 1uM; PC3; HT_HG-U133A

YLPM1 ATP1A2 PHF14

3.41e-05196835919_UP
Diseasecancer (implicated_via_orthology)

CAND1 RANBP6 CAND2

4.01e-0526883DOID:162 (implicated_via_orthology)
Diseasesusceptibility to chronic sinus infection measurement

CAND1 RANBP6

1.45e-046882EFO_0008419
Diseasecreatinine measurement

CAND1 CAND2 ARMCX3

1.89e-0399583EFO_0004518
Diseasechildhood onset asthma

RANBP6 PHF14

3.42e-0333482MONDO_0005405
Diseaseelectrocardiography

CAND2 ATP1A2

8.39e-0353082EFO_0004327
Diseasewellbeing measurement

CAND2 YLPM1

1.40e-0269282EFO_0007869
Diseaseapolipoprotein A 1 measurement

DHX38 YLPM1

2.06e-0284882EFO_0004614

Protein segments in the cluster

PeptideGeneStartEntry
RYNDWSDDDDDSNES

ARMCX3

56

Q9UH62
DDEYSDDDDMSWKVR

CAND1

336

Q86VP6
NDMDDYDSEDDNDWR

PHF14

201

O94880
DWDDRTMNDLEDSYG

ATP1A2

886

P50993
ESEDEYSDDDDMSWK

CAND2

336

O75155
DEDWVNADEMEEDDF

RANBP6

326

O60518
EDDQRQADRDWYMMD

DHX38

316

Q92620
DDWERDQDMDEDYNR

YLPM1

1266

P49750