Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	cell division site	OR2A7 OR2A4 MAEA	1.48e-04	80	27	3	GO:0032153
GeneOntologyCellularComponent	mitotic spindle midzone	OR2A7 OR2A4	1.91e-04	16	27	2	GO:1990023
GeneOntologyCellularComponent	Flemming body	OR2A7 OR2A4	9.85e-04	36	27	2	GO:0090543
GeneOntologyCellularComponent	spindle midzone	OR2A7 OR2A4	1.22e-03	40	27	2	GO:0051233
GeneOntologyCellularComponent	mitotic spindle pole	OR2A7 OR2A4	1.40e-03	43	27	2	GO:0097431
Domain	DUSP	USP20 USP33	3.01e-05	6	27	2	SM00695
Domain	DUSP	USP20 USP33	3.01e-05	6	27	2	PF06337
Domain	-	USP20 USP33	4.21e-05	7	27	2	3.30.2230.10
Domain	Pept_C19_DUSP	USP20 USP33	4.21e-05	7	27	2	IPR006615
Domain	DUSP	USP20 USP33	4.21e-05	7	27	2	PS51283
Domain	ZnF_UBP	USP20 USP33	1.10e-04	11	27	2	SM00290
Domain	zf-UBP	USP20 USP33	1.81e-04	14	27	2	PF02148
Domain	ZF_UBP	USP20 USP33	1.81e-04	14	27	2	PS50271
Domain	Znf_UBP	USP20 USP33	1.81e-04	14	27	2	IPR001607
Domain	LRR_8	LRRN4 LGR5 NTRK3	1.88e-03	171	27	3	PF13855
Domain	LRRNT	LGR5 NTRK3	2.65e-03	53	27	2	PF01462
Domain	LRR_1	LRRN4 LGR5 NTRK3	3.78e-03	219	27	3	PF00560
Domain	USP_CS	USP20 USP33	4.08e-03	66	27	2	IPR018200
Domain	USP_1	USP20 USP33	4.57e-03	70	27	2	PS00972
Domain	UCH	USP20 USP33	4.70e-03	71	27	2	PF00443
Domain	USP_2	USP20 USP33	4.70e-03	71	27	2	PS00973
Domain	USP_3	USP20 USP33	4.83e-03	72	27	2	PS50235
Domain	USP_dom	USP20 USP33	4.83e-03	72	27	2	IPR028889
Domain	Peptidase_C19_UCH	USP20 USP33	4.83e-03	72	27	2	IPR001394
Domain	Leu-rich_rpt	LRRN4 LGR5 NTRK3	6.83e-03	271	27	3	IPR001611
Domain	Cys-rich_flank_reg_C	LRRN4 NTRK3	7.45e-03	90	27	2	IPR000483
Domain	LRRCT	LRRN4 NTRK3	7.45e-03	90	27	2	SM00082
Pubmed	Deubiquitinases USP20/33 promote the biogenesis of tail-anchored membrane proteins.	USP20 USP33	5.80e-07	2	27	2	33792613
Pubmed	Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation.	OR2A7 OR2A4	1.74e-06	3	27	2	27315375
Pubmed	Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor.	USP20 USP33	1.74e-06	3	27	2	12056827
Pubmed	Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.	USP20 USP33	1.74e-06	3	27	2	12865408
Pubmed	Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 tax to negatively regulate NF-kappaB signaling.	USP20 USP33	3.48e-06	4	27	2	21525354
Pubmed	The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.	USP20 USP33	3.48e-06	4	27	2	19424180
Pubmed	A zonal organization of odorant receptor gene expression in the olfactory epithelium.	OR2A7 OR2A4	3.48e-06	4	27	2	7683976
Pubmed	Dynamic expression pattern of leucine-rich repeat neuronal protein 4 in the mouse dorsal root ganglia during development.	LRRN4 NTRK3	5.80e-06	5	27	2	23701859
Pubmed	USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110.	USP20 USP33	8.69e-06	6	27	2	23486064
Pubmed	MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors.	USP20 USP33	1.22e-05	7	27	2	23166351
Pubmed	Saturation mutagenesis defines novel mouse models of severe spine deformity.	OR2A7 OR2A4	1.62e-05	8	27	2	34142127
Pubmed	Evolution of odorant receptors expressed in mammalian testes.	OR2A7 OR2A4	4.50e-05	13	27	2	11014824
Pubmed	Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb.	OR2A7 OR2A4	5.25e-05	14	27	2	7528109
Pubmed	The DNA sequence and analysis of human chromosome 6.	FANCE LMBRD1 ENPP1 OR2A4 MRPL2	1.05e-04	622	27	5	14574404
Pubmed	OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase.	USP20 USP33	2.84e-04	32	27	2	33669244
Pubmed	Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin.	USP20 USP33	3.02e-04	33	27	2	30323974
Pubmed	A microarray of ubiquitylated proteins for profiling deubiquitylase activity reveals the critical roles of both chain and substrate.	USP20 USP33	3.60e-04	36	27	2	22626734
Pubmed	A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis.	DCAF5 NTRK3	4.01e-04	38	27	2	38346162
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	MACO1 USP20 USP33 NUP210	4.44e-04	468	27	4	31056421
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	REL TRRAP NBR1 RBL1 PRRC2C	4.62e-04	857	27	5	25609649
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	ANTXR2 PRRC2C NUP210	5.09e-04	202	27	3	24639526
Pubmed	The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation.	USP20 USP33	6.95e-04	50	27	2	26275350
Pubmed	The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo.	CDKL3 TRRAP	7.51e-04	52	27	2	28893950
Interaction	FANCE interactions	FANCE TRRAP ENPP1	6.70e-06	30	25	3	int:FANCE
Cytoband	Ensembl 112 genes in cytogenetic band chr6q23	ENPP1 OR2A4	2.24e-03	119	27	2	chr6q23
Cytoband	Ensembl 112 genes in cytogenetic band chr15q25	WHAMM NTRK3	4.00e-03	160	27	2	chr15q25
GeneFamily	Ubiquitin specific peptidases	USP20 USP33	1.40e-03	56	18	2	366
GeneFamily	Olfactory receptors, family 2	OR2A7 OR2A4	5.55e-03	113	18	2	149
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_6\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CDKL3 REL MAEA	1.13e-04	156	27	3	0f2147abcf31a26ee5b2f4d8c5d72232612a33f0
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_6\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CDKL3 REL MAEA	1.13e-04	156	27	3	cb87f12443fdc5538b856f765fcbac9406044e10
ToppCell	Children_(3_yrs)-Immune-dendritic_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	REL ANTXR2 ENPP1	1.24e-04	161	27	3	cd41abb7ae659d3d314281783a0aaad562b26037
ToppCell	11.5-Distal-Mesenchymal-Mesenchyme_SERPINF1-high\|Distal / Age, Tissue, Lineage and Cell class	LRRN4 LGR5 NTRK3	1.53e-04	173	27	3	6989c9cebcd81eccceac7e5a86152676ee959386
ToppCell	facs-Brain_Myeloid-Striatum-24m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANTXR2 TRRAP NUP210	1.63e-04	177	27	3	f6b9d91d46830d0d207b0abd4ee5a4942fd99774
ToppCell	C_00\|World / shred on cell type and cluster	LGR5 PRRC2C NUP210	1.69e-04	179	27	3	da2dadc3266ffebd4a34ac61bfa05fddcadcde4c
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	STARD13 ANTXR2 ENPP1	1.72e-04	180	27	3	fdbd7c22044d9328a1e06e2f9a4451529d1df767
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	STARD13 ANTXR2 ENPP1	1.72e-04	180	27	3	280ff5c8f292be1b88120db5ff1788b750644856
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell-D175\|Adult / Lineage, Cell type, age group and donor	LRRN4 ENPP1 NTRK3	1.77e-04	182	27	3	ad4d74d8b19976e1ccc3c5ba8013199338cf6fd8
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FANCE LGR5 NTRK3	1.89e-04	186	27	3	aa88d9573a237b2b8e6025fee31f69fbce824497
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FANCE LGR5 NTRK3	1.89e-04	186	27	3	ecc5acd111a6ee50d59544d1bdd7ed94e2812aae
ToppCell	facs-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FANCE LGR5 NTRK3	1.89e-04	186	27	3	26458ff8cad5577de4306cffa0ca69eb26940e0d
ToppCell	facs-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FANCE LGR5 NTRK3	1.89e-04	186	27	3	a71397efc68d2916ddc373d92cfd07be58033e1c
ToppCell	facs-Lung-nan-3m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LGR5 ENPP1 NTRK3	2.01e-04	190	27	3	834218fcc59df5e7e52de154272f3d55d81d0dac
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPATC1 REL ANTXR2	2.01e-04	190	27	3	2ff4b50b864a35f22c558d7d585cd2b54612b50c
ToppCell	facs-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LGR5 ENPP1 NTRK3	2.01e-04	190	27	3	c7bd087f36321cec61b98657433b4d19d135791f
ToppCell	PBMC-Severe-cDC_12\|Severe / Compartment, Disease Groups and Clusters	FANCE RBL1 NUP210	2.01e-04	190	27	3	84ee185939bdefb10705b621a70da27701eadcee
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs-Migratory_DCs_L.1.2.1.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPATC1 REL ANTXR2	2.01e-04	190	27	3	5175bf022d55a52988014abe7cece326a8406a38
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-dendritic_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPATC1 REL ANTXR2	2.01e-04	190	27	3	29e60b9b1c86b44550619c01306b8b1bb2e340dc
ToppCell	facs-Lung-3m-Mesenchymal-myofibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LGR5 ENPP1 NTRK3	2.04e-04	191	27	3	fd8331c7abdd999f55ba43d307945c6abfccbf84
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	STARD13 ANTXR2 ENPP1	2.08e-04	192	27	3	4022f208eb5db760abd0aac782a25e8ab63efc64
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	STARD13 ANTXR2 ENPP1	2.08e-04	192	27	3	9333aba0d04203ccccad78d82bf6359922f810a7
ToppCell	COVID-19_Mild\|World / Disease condition and Cell class	WHAMM REL PRRC2C	2.11e-04	193	27	3	7256a5a491536c525b31ae96d47ab5c6303cb73a
ToppCell	P28-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	LGR5 ENPP1 NTRK3	2.14e-04	194	27	3	3c661c6768c3f05d2aba03d329adb257ca201b2d
ToppCell	facs-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LGR5 ENPP1 NTRK3	2.17e-04	195	27	3	c6bb16c0076639c6ddef1a15d8cba44bc29c077d
ToppCell	facs-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LGR5 ENPP1 NTRK3	2.17e-04	195	27	3	ea89f80d3d7e9f737442f7c1aa1791d277ffc90c
ToppCell	BAL-Control-Myeloid-cDC-cDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	REL ANTXR2 ENPP1	2.24e-04	197	27	3	15e683f4a610aad3e06723747c8e56ca25f57414
ToppCell	BAL-Control-Myeloid-cDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	REL ANTXR2 ENPP1	2.24e-04	197	27	3	6ac50c02899531a25885749d5305da788dfa9dbc
ToppCell	BAL-Control-Myeloid-cDC-cDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	REL ANTXR2 ENPP1	2.24e-04	197	27	3	6f83fc049f38f3de6bc5180ad4b51ceb4d5dcdb6
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	WHAMM REL PRRC2C	2.24e-04	197	27	3	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	Control-Myeloid-cDC\|Control / Disease group,lineage and cell class （2021.01.30）	REL ANTXR2 ENPP1	2.24e-04	197	27	3	aef933107da42a763b35041c90950db07707c0cb
ToppCell	BAL-Control-Myeloid-cDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	REL ANTXR2 ENPP1	2.24e-04	197	27	3	513ada82bbbb6a624d89edaa54f8c4a303dfb5e7
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	WHAMM REL PRRC2C	2.27e-04	198	27	3	44417089b62056269cac38d3134ff209c05b7007
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	WHAMM REL PRRC2C	2.27e-04	198	27	3	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	distal-Hematologic-Myeloid_Dendritic_Type_1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	REL ANTXR2 ENPP1	2.31e-04	199	27	3	6fc8c321e2ddd802b9c8edfe16e006c7d4d862fc
ToppCell	lymphoid-NK_cell-NK_cell\|NK_cell / Lineage, cell class and subclass	WHAMM REL PRRC2C	2.31e-04	199	27	3	945fbf5845403a8b22d04963f50ad69c414b6153
Computational	Neighborhood of BAG5	PRRC2C MAEA USP33	1.44e-05	38	14	3	GCM_BAG5
Disease	Large cell carcinoma of lung	TRRAP NTRK3	3.10e-04	32	24	2	C0345958
Disease	Gastric Adenocarcinoma	TRRAP NTRK3	6.14e-04	45	24	2	C0278701
Disease	chemokine (C-C motif) ligand 27 measurement	SLCO1B7 STARD13	1.48e-03	70	24	2	EFO_0008082
Disease	Endometriosis	ENPP1 NTRK3	7.55e-03	161	24	2	C0014175
Disease	Endometrioma	ENPP1 NTRK3	7.55e-03	161	24	2	C0269102
Disease	Leukemia, Myelocytic, Acute	FANCE NTRK3	8.67e-03	173	24	2	C0023467

Protein segments in the cluster

Peptide	Gene	Start	Entry
PPINLTNSNLMAANL	CDKL3	431	Q8IVW4
SVQLNSMLCPAPILN	ANTXR2	271	P58335
QLQNLLPLFCMSPEN	DNHD1	3866	Q96M86
PQLDMSCPLLQQNKQ	NUP210	761	Q8TEM1
LNKLAQPLPMAHCAN	MAEA	321	Q7L5Y9
QLPLFRMNISQCDLP	NTRK3	196	Q16288
ANLSNPLNMLLPLLQ	LMBRD1	346	Q9NUN5
DLMENCIPNNQLSKP	MACO1	366	Q8N5G2
CLNIAMAQRNQDLPP	DCAF5	711	Q96JK2
NLMCDLLNLTPAPNN	ENPP1	571	P22413
NPMLNPLICSLRNSE	OR2A7	281	Q96R45
NPMLNPLICSLRNSE	OR2A4	281	O95047
PSQMDLLCAQLQLPQ	FANCE	321	Q9HB96
MTPNLQQLDCQDSPA	LRRN4	251	Q8WUT4
LDLSMNNISQLLPNP	LGR5	71	O75473
MQCIQIPNGDLQNSP	STARD13	301	Q9Y3M8
LLQSNTLMLPLQPCT	NBR1	351	Q14596
ANAIMCPNRQDLLNP	RBL1	211	P28749
LSCMPSLIAQQQQNP	PRRC2C	2361	Q9Y520
NLPSDLSQQMCLPAS	WHAMM	566	Q8TF30
NLPNCLINQMLSLNR	SLCO1B7	91	G3V0H7
QNLLANPMSNLVLPE	SPATC1	211	Q76KD6
NGLLQQPSALMLLPC	MRPL2	36	Q5T653
NPRLLSMNLENPSCN	REL	511	Q04864
MNAALQALSNCPPLT	USP20	156	Q9Y2K6
PLLPNLLQGLNMLQS	TRRAP	781	Q9Y4A5
MNAALQALSNCPPLT	USP33	196	Q8TEY7
QMENLLLAQPLPDDC	nan	46	Q8TCH9