Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionSH3 domain binding

MICAL1 SHANK2 WAS SH3BP1 RIMS1

1.56e-04143715GO:0017124
GeneOntologyBiologicalProcesssupramolecular fiber organization

MICAL1 ABL2 WAS ARHGEF5 TOGARAM2 SH3BP1 OBSCN FMN2 ZNF207 PRKD1 DYSF WASF1 GOLGA2 PCM1

4.71e-069577214GO:0097435
GeneOntologyBiologicalProcessneuron projection morphogenesis

TNIK PRTG ABL2 NFIX GORASP1 EIF4G2 RIMS1 RERE PIAS2 WASF1 GOLGA2 GFRA3

1.98e-058027212GO:0048812
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

TNIK PRTG ABL2 NFIX GORASP1 EIF4G2 RIMS1 RERE PIAS2 WASF1 GOLGA2 GFRA3

2.43e-058197212GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

TNIK PRTG ABL2 NFIX GORASP1 EIF4G2 RIMS1 RERE PIAS2 WASF1 GOLGA2 GFRA3

2.64e-058267212GO:0048858
GeneOntologyBiologicalProcessregulation of organelle organization

ABL2 WAS ARHGEF5 CASKIN1 BUB1 YLPM1 SEC16A TOGARAM2 SH3BP1 ZNF207 PRKD1 RIMS1 DYSF WASF1 RAD21

5.02e-0513427215GO:0033043
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

TNIK PRTG ABL2 NFIX GORASP1 EIF4G2 RERE REST PIAS2 GOLGA2 GFRA3

5.33e-057487211GO:0048667
GeneOntologyBiologicalProcesscell morphogenesis

TNIK PRTG ABL2 NFIX GORASP1 EIF4G2 RIMS1 RERE REST PIAS2 WASF1 GOLGA2 ZMYM3 GFRA3

5.58e-0511947214GO:0000902
GeneOntologyBiologicalProcessneuron projection development

TNIK PRTG ABL2 NFIX GORASP1 EIF4G2 PRKD1 RIMS1 RERE REST PIAS2 WASF1 GOLGA2 GFRA3

1.22e-0412857214GO:0031175
DomainSurp

CHERP SF3A1

2.24e-046732PF01805
DomainSWAP

CHERP SF3A1

2.24e-046732SM00648
DomainSURP

CHERP SF3A1

2.24e-046732PS50128
DomainSurp

CHERP SF3A1

2.24e-046732IPR000061
DomainRNA_pol_II-bd

CHERP SCAF8

3.12e-047732IPR006903
DomainCTD_bind

CHERP SCAF8

3.12e-047732PF04818
DomainRPR

CHERP SCAF8

4.16e-048732SM00582
DomainCID

CHERP SCAF8

4.16e-048732PS51391
DomainCID_dom

CHERP SCAF8

4.16e-048732IPR006569
DomainWH2

WAS WASF1

1.33e-0314732SM00246
DomainSH3

ABL2 SHANK2 ARHGEF5 CASKIN1 OBSCN

1.57e-03216735SM00326
DomainSH3

ABL2 SHANK2 ARHGEF5 CASKIN1 OBSCN

1.57e-03216735PS50002
DomainSH3_domain

ABL2 SHANK2 ARHGEF5 CASKIN1 OBSCN

1.70e-03220735IPR001452
DomainWH2

WAS WASF1

1.75e-0316732PF02205
Domain-

SHANK2 GORASP1 RIMS1 PDZD4

2.83e-031507342.30.42.10
DomainPDZ

SHANK2 GORASP1 RIMS1 PDZD4

2.90e-03151734PS50106
DomainPDZ

SHANK2 GORASP1 RIMS1 PDZD4

2.97e-03152734IPR001478
DomainWH2_dom

WAS WASF1

3.02e-0321732IPR003124
DomainWH2

WAS WASF1

3.93e-0324732PS51082
Domain-

CHERP SCAF8

4.61e-03267321.25.40.90
DomainSH3_2

SHANK2 ARHGEF5 CASKIN1

4.65e-0386733IPR011511
DomainSH3_2

SHANK2 ARHGEF5 CASKIN1

4.65e-0386733PF07653
DomainENTH_VHS

CHERP SCAF8

5.71e-0329732IPR008942
DomainFN3

PAPPA2 PRTG PTPRB OBSCN

5.96e-03185734SM00060
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

CBLL1 TNIK ZNF462 SHANK2 CASKIN1 YLPM1 SEC16A SH3BP1 ANKRD17 PRKD1 RIMS1 UBN2 WASF1 GOLGA2 PCM1 WNK2

1.58e-10963741628671696
Pubmed

Human transcription factor protein interaction networks.

ZNF462 PRR12 TCERG1 SCAF8 TLE1 NFIX YLPM1 BMS1 SEC16A GON4L ANKRD17 RERE UBN2 PIAS2 ZMYM3 PCM1 RAI2 RAD21

8.17e-101429741835140242
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

ZNF462 PRR12 TLE1 BUB1 SEC16A ANKRD17 RERE PIAS2 ZMYM3 PCM1

2.05e-08418741034709266
Pubmed

WW domains provide a platform for the assembly of multiprotein networks.

CHERP WAS TCERG1 SF3A1 YLPM1 ZNF207 PRRC1

4.08e-0815474716055720
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ZNF462 THAP4 PTPRB SHANK2 MEGF6 SCAF8 NFIX OBSCN ANKRD17 PRKD1 RIMS1 RERE GNAS UBN2 PCM1 WNK2

7.55e-081489741628611215
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

SCAF8 SF3A1 YLPM1 EIF4G2 SEC16A ANKRD17 RIMS1 RERE REST CCDC9 ZMYM3 PCM1

8.42e-08774741215302935
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

PRR12 CHERP SCAF8 NFIX YLPM1 SEC16A PIAS2

1.19e-0718074735198878
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

RNGTT TCERG1 BUB1 SEC16A GNAS UBN2 PIAS2 GOLGA2 ZMYM3 PCM1

4.81e-07588741038580884
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

CBLL1 PRR12 RNGTT SHANK2 TCERG1 SCAF8 BMS1 EIF4G2 RBM42 GON4L ANKRD17 ZNF207 UBN2 ZMYM3 RAD21

5.01e-071497741531527615
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

CBLL1 THAP4 PRR12 CHERP TCERG1 NFIX SF3A1 YLPM1 EIF4G2 RBM42 REST UBN2 ZMYM3 RAD21

5.14e-071294741430804502
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

CBLL1 YBX2 CHERP TCERG1 SF3A1 YLPM1 EIF4G2 SEC16A ZNF207 UBN2 PCM1 RAD21

7.79e-07954741236373674
Pubmed

Interaction network of human early embryonic transcription factors.

ZNF462 PRR12 TLE1 SEC16A RERE UBN2 PIAS2 ZMYM3

8.39e-0735174838297188
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

PRR12 CHERP TLE1 NFIX YLPM1 RERE UBN2

1.73e-0626874733640491
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

THAP4 PRR12 RNGTT TCERG1 SF3A1 EIF4G2 TOGARAM2 ZNF207 UBN2 ZMYM3 PCM1 RAD21

3.50e-061103741234189442
Pubmed

The Golgi protein GM130 regulates centrosome morphology and function.

GORASP1 GOLGA2

4.47e-06274218045989
Pubmed

Hierarchical regulation of WASP/WAVE proteins.

WAS WASF1

4.47e-06274218995840
Pubmed

WASP and SCAR are evolutionarily conserved in actin-filled pseudopod-based motility.

WAS WASF1

4.47e-06274228473602
Pubmed

Identification of Wiskott-Aldrich syndrome protein (WASP) binding sites on the branched actin filament nucleator Arp2/3 complex.

WAS WASF1

4.47e-06274229386393
Pubmed

Inheriting a structural scaffold for Golgi biosynthesis.

GORASP1 GOLGA2

4.47e-06274212111718
Pubmed

GRASP65, a protein involved in the stacking of Golgi cisternae.

GORASP1 GOLGA2

4.47e-0627429346242
Pubmed

GM130 and GRASP65-dependent lateral cisternal fusion allows uniform Golgi-enzyme distribution.

GORASP1 GOLGA2

4.47e-06274216489344
Pubmed

Structural basis for the interaction between the Golgi reassembly-stacking protein GRASP65 and the Golgi matrix protein GM130.

GORASP1 GOLGA2

4.47e-06274226363069
Pubmed

The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment.

GORASP1 GOLGA2

4.47e-06274211781572
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

CHERP GORASP1 SF3A1 BUB1 YLPM1 GNAS CCDC9 GOLGA2 PRRC1 ZMYM3 PCM1 RAD21

5.59e-061155741220360068
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

PRR12 SCAF8 TLE1 YLPM1 BMS1 SEC16A ANKRD17 ZNF207

5.90e-0645774832344865
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

PRR12 TCERG1 SCAF8 CASKIN1 SH3BP1 FMN2 PCM1 RAD21

7.82e-0647574831040226
Pubmed

A human MAP kinase interactome.

ABL2 WAS RASAL3 TCERG1 ANKRD17 PIAS2 GOLGA2 WNK2

9.23e-0648674820936779
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

PRR12 TCERG1 SCAF8 ARHGEF5 GORASP1 BUB1 GON4L ANKRD17 GOLGA2

9.87e-0665074938777146
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

CHERP SF3A1 YLPM1 BMS1 SEC16A ANKRD17 ZMYM3 PCM1 RAD21

1.02e-0565374922586326
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

ZNF462 PRR12 CHERP TCERG1 SF3A1 BMS1 ANKRD17 GOLGA2 ZMYM3 RAD21

1.22e-05847741035850772
Pubmed

Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis--Golgi tethering.

GORASP1 GOLGA2

1.34e-05374211285137
Pubmed

N-WASP involvement in dorsal ruffle formation in mouse embryonic fibroblasts.

WAS WASF1

1.34e-05374217182853
Pubmed

Mapping the interaction between GRASP65 and GM130, components of a protein complex involved in the stacking of Golgi cisternae.

GORASP1 GOLGA2

1.34e-0537429628863
Pubmed

Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins.

SHANK2 CASKIN1

1.34e-05374231727973
Pubmed

Critical conformational changes in the Arp2/3 complex are induced by nucleotide and nucleation promoting factor.

WAS WASF1

1.34e-05374215494313
Pubmed

GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system.

GORASP1 GOLGA2

1.34e-05374210487747
Pubmed

Markers of malignant prostate cancer cells: Golgi localization of α-mannosidase 1A at GM130-GRASP65 site and appearance of high mannose N-glycans on cell surface.

GORASP1 GOLGA2

1.34e-05374232331836
Pubmed

Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins.

ABL2 CHERP SF3A1

1.38e-052274326420826
Pubmed

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

CBLL1 DPYD PIAS2 ADAMTSL4 GOLGA2 ZMYM3 RAI2

2.42e-0540274724722188
Pubmed

Shifted Golgi targeting of glycosyltransferases and α-mannosidase IA from giantin to GM130-GRASP65 results in formation of high mannose N-glycans in aggressive prostate cancer cells.

GORASP1 GOLGA2

2.67e-05474228782625
Pubmed

Interaction between Wiskott-Aldrich Syndrome protein (WASP) and the Fyn protein-tyrosine kinase.

WAS WASF1

2.67e-05474210532312
Pubmed

Motility determinants in WASP family proteins.

WAS WASF1

2.67e-05474212429845
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

TNIK CHERP TCERG1 SF3A1 YLPM1 EIF4G2 SEC16A ANKRD17 PCM1 RAD21

2.82e-05934741033916271
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

TNIK TCERG1 SF3A1 YLPM1 BMS1 SEC16A RBM42 ANKRD17 ZNF207 GNAS GOLGA2 PCM1

3.07e-051371741236244648
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

TNIK ABL2 SHANK2 RIMS1 GNAS WASF1

3.08e-0528174628706196
Pubmed

The functional interactome landscape of the human histone deacetylase family.

YBX2 SF3A1 YLPM1 SEC16A RERE ZMYM3

3.60e-0528974623752268
Pubmed

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.

CHERP RNGTT SF3A1 BUB1 BMS1 EIF4G2 RBM42 ANKRD17 ZNF207 GNAS

3.92e-05971741033306668
Pubmed

Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization.

WAS WASF1

4.45e-05574210563804
Pubmed

The DNA/RNA-binding protein MSY2 marks specific transcripts for cytoplasmic storage in mouse male germ cells.

YBX2 ACR

4.45e-05574215665108
Pubmed

Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells.

WAS WASF1

4.45e-0557429307968
Pubmed

Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism for Golgi checkpoint signalling.

GORASP1 GOLGA2

4.45e-05574215678101
Pubmed

A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex.

WAS WASF1

4.45e-05574212872157
Pubmed

MICAL-1 isoforms, novel rab1 interacting proteins.

MICAL1 GOLGA2

4.45e-05574212788069
Pubmed

Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex.

WAS WASF1

4.45e-05574211052943
Pubmed

Biological insights from 108 schizophrenia-associated genetic loci.

PRR12 DPYD TLE1 PRKD1 RIMS1 GFRA3

4.69e-0530374625056061
Pubmed

A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic.

GORASP1 GOLGA2

6.66e-05674211739401
Pubmed

HIV-1 Nef perturbs the function, structure, and signaling of the Golgi through the Src kinase Hck.

GORASP1 GOLGA2

6.66e-05674221567396
Pubmed

Temporal control of a dendritogenesis-linked gene via REST-dependent regulation of nuclear factor I occupancy.

NFIX REST

6.66e-05674221270437
Pubmed

Characterization of YIPF3 and YIPF4, cis-Golgi Localizing Yip domain family proteins.

GORASP1 GOLGA2

6.66e-05674221757827
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

TNIK RIN3 ABL2 SHANK2 RIMS1 WNK2

7.39e-0532974617474147
Pubmed

Oct4 links multiple epigenetic pathways to the pluripotency network.

NID2 TCERG1 SCAF8 ANKRD17 RAD21

7.49e-0520374522083510
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

TCERG1 SF3A1 EIF4G2 PIAS2 ZMYM3 RAD21

7.76e-0533274632786267
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

ABL2 TCERG1 ARHGEF5 SEC16A FMN2 ANKRD17 GNAS PRRC1 PCM1

8.79e-0586174936931259
Pubmed

Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex.

WAS WASF1

9.31e-0577429889097
Pubmed

Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.

WAS YLPM1 ANKRD17 GOLGA2

9.52e-0511174422558309
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

CBLL1 ZNF462 CHERP TCERG1 SF3A1 YLPM1 BMS1 RBM42 ZNF207 ZMYM3

9.63e-051082741038697112
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

ABL2 SHANK2 CASKIN1 FMN2 RIMS1 PCM1

9.89e-0534774617114649
Pubmed

Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.

CHERP TCERG1 SF3A1 ZNF207

1.09e-0411574417332742
Pubmed

ATG5 is required for B cell polarization and presentation of particulate antigens.

MICAL1 WAS TCERG1 YLPM1 EIF4G2 CCDC9 GOLGA2 PCM1

1.22e-0470174830196744
Pubmed

Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex.

WAS WASF1

1.24e-04874210381382
Pubmed

Casein kinase 1δ functions at the centrosome and Golgi to promote ciliogenesis.

GOLGA2 PCM1

1.24e-04874224648492
Pubmed

Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus.

GORASP1 GOLGA2

1.24e-04874211739402
Pubmed

Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex.

WAS WASF1

1.24e-04874211146629
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

TNIK CHERP SCAF8 TLE1 YLPM1 SEC16A PRRC1 PCM1

1.66e-0473374834672954
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

PRR12 TLE1 NFIX SEC16A GON4L RAI2

2.08e-0439874635016035
Pubmed

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.

CHERP TCERG1 SF3A1 YLPM1 SEC16A ZNF207

2.11e-0439974635987950
Pubmed

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.

EIF4G2 SEC16A ANKRD17 GOLGA2 PCM1

2.21e-0425674533397691
Pubmed

Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.

RNGTT ARHGEF5 GNAS PCM1

2.26e-0413974425476789
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TNIK SCAF8 SEC16A GON4L RERE ZMYM3

2.34e-0440774612693553
Pubmed

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

CBLL1 NID2 CHERP TCERG1 TLE1 SF3A1 SEC16A SH3BP1 ZNF207 RERE GNAS

2.40e-041451741130550785
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

CHERP SCAF8 SF3A1 BUB1 YLPM1 GNAS RAD21

2.42e-0458274720467437
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

TCERG1 SEC16A KIAA1549 GOLGA2 PDZD4

2.51e-0426374534702444
Pubmed

Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.

PRR12 YBX2 SF3A1 WASF1

2.52e-0414374432560809
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

RASAL3 ARHGEF5 BUB1 YLPM1 PRRC1 WNK2

3.14e-0443074635044719
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

CHERP TCERG1 SF3A1 YLPM1 BMS1 EIF4G2 ZNF207 CCDC9

3.17e-0480774822681889
Pubmed

The DNA sequence and biological annotation of human chromosome 1.

PAPPA2 ABL2 MEGF6 OBSCN FMN2 GON4L RERE TMEM222 ADAMTSL4

3.36e-04103174916710414
Pubmed

The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.

SH3BP1 RBM42 ZNF207 DYSF RAD21

3.40e-0428174524163370
Pubmed

WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.

WAS WASF1

3.43e-041374216723544
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

TCERG1 SF3A1 YLPM1 BMS1 PIAS2

3.51e-0428374530585729
Pubmed

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.

DPYD RERE BANK1

3.67e-046574323453885
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

TCERG1 EIF4G2 SEC16A ZNF207 UBN2 PIAS2

3.73e-0444474634795231
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

YLPM1 EIF4G2 ANKRD17 PRKD1 PCM1 WNK2

4.60e-0446274631138677
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

TCERG1 TLE1 NFIX SF3A1 BMS1 ANKRD17 WASF1 ZMYM3

4.72e-0485774825609649
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

YBX2 CHERP YLPM1 SEC16A ANKRD17 RERE GNAS

4.92e-0465574735819319
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

CBLL1 ZNF462 ZNF207 REST CCDC9 RAD21

4.97e-0446974627634302
Pubmed

Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules.

REST RAD21

5.26e-041674222780989
Pubmed

Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.

ZNF462 REST ZMYM3

5.38e-047474329795351
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PRR12 RIN3 SHANK2 MEGF6 CASKIN1 SEC16A OBSCN DYSF WNK2

5.54e-04110574935748872
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

NID2 RASAL3 SEC16A KIAA1549 FMN2 ANKRD17 RERE ZMYM3 PCM1

5.95e-04111674931753913
Pubmed

A method to identify cDNAs based on localization of green fluorescent protein fusion products.

YLPM1 ZNF207

5.95e-041774210716735
InteractionEGR2 interactions

ZNF462 PRR12 TLE1 SEC16A RERE UBN2 PIAS2 GOLGA2

1.72e-07171728int:EGR2
InteractionTLE3 interactions

CBLL1 PRR12 CHERP SCAF8 TLE1 NFIX ZNF207 RERE UBN2 GOLGA2

8.70e-073767210int:TLE3
InteractionAR interactions

ZNF462 PRR12 ABL2 CHERP TLE1 NFIX YLPM1 SEC16A PNRC1 PRKD1 RERE GNAS UBN2 PIAS2 PCM1

1.80e-069927215int:AR
InteractionSNRNP40 interactions

CBLL1 ZNF462 CHERP RNGTT TCERG1 SCAF8 SF3A1 BMS1 RBM42 GON4L ZNF207 UBN2

2.43e-066377212int:SNRNP40
InteractionWBP4 interactions

CHERP WAS TCERG1 SF3A1 RBM42 ZNF207

2.55e-06109726int:WBP4
InteractionQPRT interactions

TLE1 SF3A1 EIF4G2 ANKRD17 ADAMTSL4

1.25e-0584725int:QPRT
InteractionSP7 interactions

PRR12 TCERG1 SCAF8 TLE1 NFIX YLPM1 RERE PIAS2

1.27e-05304728int:SP7
InteractionITSN2 interactions

RIN3 WAS YLPM1 KIAA1549 ANKRD17 GOLGA2

1.43e-05147726int:ITSN2
InteractionCYFIP2 interactions

TNIK PRR12 YBX2 RIN3 TCERG1 SF3A1 CASKIN1 WASF1

1.96e-05323728int:CYFIP2
InteractionDTX2 interactions

PRR12 CHERP SCAF8 NFIX YLPM1 SEC16A PIAS2 GOLGA2

2.29e-05330728int:DTX2
InteractionYWHAH interactions

RIN3 ABL2 TCERG1 ARHGEF5 SEC16A FMN2 ANKRD17 PRKD1 RIMS1 PIAS2 WASF1 PRRC1 PCM1 WNK2

2.99e-0511027214int:YWHAH
InteractionTRIP10 interactions

ABL2 WAS SF3A1 SH3BP1 WASF1

4.43e-05109725int:TRIP10
InteractionSORBS2 interactions

TNIK ABL2 WAS WASF1 GOLGA2

4.83e-05111725int:SORBS2
InteractionALG13 interactions

PRR12 SCAF8 TLE1 SEC16A RERE PCM1

4.91e-05183726int:ALG13
InteractionCRK interactions

MICAL1 RIN3 ABL2 RNGTT ARHGEF5 BUB1 SH3BP1 WASF1

5.14e-05370728int:CRK
InteractionRCOR1 interactions

TNIK BUB1 SEC16A ANKRD17 REST PIAS2 GOLGA2 ZMYM3 PCM1

6.42e-05494729int:RCOR1
InteractionSORBS3 interactions

PNMA5 MICAL1 RIN3 ABL2 CHERP ADAMTSL4

8.49e-05202726int:SORBS3
InteractionFEV interactions

ZNF462 PRR12 TLE1 UBN2 PIAS2 ZMYM3

8.72e-05203726int:FEV
InteractionARHGAP12 interactions

PRR12 SHANK2 YLPM1 WASF1

1.03e-0468724int:ARHGAP12
InteractionAGAP2 interactions

TNIK ABL2 SHANK2 RIMS1 GNAS WASF1

1.05e-04210726int:AGAP2
InteractionGRB2 interactions

PNMA5 MICAL1 RIN3 ABL2 WAS TCERG1 ARHGEF5 YLPM1 SH3BP1 PNRC1 WASF1

1.27e-048067211int:GRB2
InteractionSMG7 interactions

PRR12 SCAF8 TLE1 YLPM1 SEC16A ANKRD17 PCM1

1.42e-04319727int:SMG7
InteractionHOMER1 interactions

TNIK SHANK2 RASAL3 PIAS2 WASF1

1.45e-04140725int:HOMER1
InteractionABI1 interactions

TNIK RIN3 ABL2 TCERG1 WASF1 PCM1

1.46e-04223726int:ABI1
InteractionSIX2 interactions

TLE1 ANKRD17 PRKD1

1.49e-0429723int:SIX2
InteractionCRKL interactions

RIN3 ABL2 WAS MEGF6 ARHGEF5 PNRC1

1.61e-04227726int:CRKL
InteractionNEBL interactions

NUTM1 NID2 GOLGA2 PCM1

1.84e-0479724int:NEBL
InteractionSMC5 interactions

CBLL1 YBX2 CHERP TCERG1 SF3A1 YLPM1 EIF4G2 SEC16A ZNF207 UBN2 PCM1 RAD21

2.04e-0410007212int:SMC5
InteractionMEN1 interactions

ZNF462 PRR12 CHERP TCERG1 SF3A1 YLPM1 BMS1 ANKRD17 RERE GOLGA2 ZMYM3 RAD21

2.65e-0410297212int:MEN1
InteractionGSC interactions

ZNF462 PRR12 TLE1 RERE

2.66e-0487724int:GSC
InteractionPRPS2 interactions

RIN3 ARHGEF5 SF3A1 PRKD1 GOLGA2 RAD21

2.88e-04253726int:PRPS2
InteractionCRX interactions

ZNF462 PRR12 TLE1 RERE UBN2 ZMYM3

2.95e-04254726int:CRX
InteractionHDAC4 interactions

PRR12 TCERG1 SCAF8 CASKIN1 SH3BP1 FMN2 REST GOLGA2 PCM1 RAD21

3.00e-047447210int:HDAC4
InteractionSNRPA interactions

RASAL3 TCERG1 ARHGEF5 SF3A1 YLPM1 RBM42 ZNF207 ENOX2

3.16e-04482728int:SNRPA
InteractionPAX6 interactions

ZNF462 PRR12 TLE1 NFIX UBN2 ZMYM3 RAD21

3.29e-04366727int:PAX6
InteractionNCK2 interactions

TNIK MICAL1 ABL2 WAS YLPM1 WASF1

3.48e-04262726int:NCK2
GeneFamilyPDZ domain containing

SHANK2 GORASP1 RIMS1 PDZD4

5.02e-041524441220
GeneFamilyWiskott-Aldrich Syndrome protein family

WAS WASF1

6.80e-041644214
GeneFamilyAnkyrin repeat domain containing

SHANK2 CASKIN1 ANKRD17 BANK1

2.79e-03242444403
GeneFamilyFibronectin type III domain containing

PRTG PTPRB OBSCN

6.91e-03160443555
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

GON4L RERE

7.37e-0353442532
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ARHGEF5 OBSCN

1.12e-0266442722
GeneFamilyRNA binding motif containing

SCAF8 RBM42 ENOX2

1.50e-02213443725
GeneFamilySterile alpha motif domain containing

SHANK2 CASKIN1

1.94e-0288442760
CoexpressionZHONG_PFC_C3_ASTROCYTE

MICAL1 DPYD SHANK2 MEGF6 NFIX OBSCN RERE UBN2 PDZD4

1.34e-06389739M39102
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

ZNF462 SHANK2 MEGF6 WDR97 TCERG1 NFIX CASKIN1 KIAA1549 RIMS1 UBN2 PIAS2 WASF1 PDZD4

1.03e-0511067313M39071
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MICAL1 CASKIN1 REST WNK2 RAI2

1.95e-06123745a45d6907c041ad3f3218cd46dccfc25d4bd961cb
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPPA2 CLCA4 WAS RASAL3 GFRA3

6.44e-061577457fdc0094dd5729990a91a30c1982a14c74650b52
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid-microglial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPPA2 CLCA4 WAS RASAL3 GFRA3

6.44e-06157745c762b03e254c73222094725ca8ac1c8eb428bccb
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPPA2 CLCA4 WAS RASAL3 GFRA3

6.44e-061577456b5b08bb5520fcf6f4c0560f7ed7645ec179806d
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-bronchial_smooth_muscle_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF462 DPYD ARHGEF5 RIMS1 WASF1

1.58e-051897454dc32b463546bbe7250dddd281b92ad17ec22da1
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Airway_Smooth_Muscle|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF462 DPYD ARHGEF5 RIMS1 WASF1

1.58e-051897450d06bf0d7191d13a1c4f30a7881e7ea1093bfd6f
ToppCellhuman_hepatoblastoma-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

TCERG1 PRKD1 RERE PCM1 RAD21

1.70e-05192745916fbec1c7ab7969bda711886ac88e877e30c280
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

PTPRB ACR KIAA1549 RIMS1 DYSF

1.79e-0519474568004855b23fe1e31e8452d70effabc78a4a0bd3
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

PTPRB OBSCN KIAA1549 RIMS1 DYSF

1.79e-0519474540842a7160f337bfc191ee15fbda3e3d38a04c57
ToppCell(02)_Cycling_Basal_(regeneration)-(4)_1wkpi|(02)_Cycling_Basal_(regeneration) / shred by cell type and Timepoint

MICAL1 RASAL3 DYSF GFRA3

2.64e-05103744942cc6f9699f777638e59aee40a402a16fdbb2e7
DrugChlorambucil [305-03-3]; Down 200; 13.2uM; PC3; HT_HG-U133A

TNIK PAPPA2 RNGTT TLE1 BUB1 PCM1

3.24e-051897363788_DN
DrugBendroflumethiazide [73-48-3]; Down 200; 9.4uM; PC3; HT_HG-U133A

RIN3 WAS GON4L RERE GOLGA2 PCM1

3.75e-051947363758_DN
DrugRapamycin; Down 200; 0.1uM; PC3; HT_HG-U133A

NID2 RIN3 RBM42 PIAS2 GOLGA2 PCM1

3.86e-051957361207_DN
DrugDapsone [80-08-0]; Down 200; 16.2uM; PC3; HT_HG-U133A

NID2 RIN3 RNGTT NFIX GNAS PCM1

3.86e-051957365078_DN
DrugTobramycin [32986-56-4]; Down 200; 8.6uM; MCF7; HT_HG-U133A

RNGTT TLE1 BUB1 REST GOLGA2 PCM1

3.97e-051967364162_DN
DrugAjmalicine hydrochloride [4373-34-6]; Down 200; 10.2uM; PC3; HT_HG-U133A

TNIK RNGTT BUB1 CCDC9 GOLGA2 ENOX2

4.09e-051977366360_DN
DrugZaprinast [37762-06-4]; Up 200; 14.8uM; HL60; HG-U133A

CBLL1 RNGTT WAS TLE1 BUB1 PRRC1

4.21e-051987361611_UP
DrugMethimazole [60-56-0]; Down 200; 35uM; PC3; HT_HG-U133A

NID2 MICAL1 SHANK2 RERE REST GOLGA2

4.21e-051987364550_DN
DrugLoracarbef [121961-22-6]; Up 200; 10.8uM; MCF7; HT_HG-U133A

ABL2 TLE1 PRKD1 RERE GNAS ENOX2

4.21e-051987365492_UP
DrugLisuride (S)(-) [18016-80-3]; Up 200; 11.8uM; PC3; HT_HG-U133A

PAPPA2 ABL2 RNGTT GON4L RERE ENOX2

4.21e-051987366682_UP
Diseasepresubiculum volume

TNIK WAS WNK2

5.96e-0531723EFO_0009400
Diseasecortical thickness

TNIK ZNF462 PRTG RIN3 NFIX YLPM1 FMN2 RERE DYSF BANK1 WNK2

7.68e-0511137211EFO_0004840
Diseasereaction time measurement

TNIK DPYD NFIX RIMS1 RERE DYSF BANK1 PRRC1

2.00e-04658728EFO_0008393
Diseaseurticaria, response to non-steroidal anti-inflammatory, angioedema

RIMS1 BANK1

2.09e-049722EFO_0005531, EFO_0005532, EFO_0005533
Diseasecortical surface area measurement

TNIK PRTG RIN3 MEGF6 NFIX PRKD1 RERE REST DYSF BANK1 WNK2

3.97e-0413457211EFO_0010736
DiseaseIntellectual Disability

ZNF462 PRR12 SHANK2 GON4L GNAS WASF1

7.85e-04447726C3714756
Diseasecognitive function measurement, self reported educational attainment

PRR12 DPYD NFIX PRKD1 BANK1

1.77e-03355725EFO_0004784, EFO_0008354
Diseasesleep duration

TNIK PRR12 DPYD PNRC1 BANK1

1.93e-03362725EFO_0005271
Diseasebrain measurement, neuroimaging measurement

TNIK ZNF462 PRTG RIN3 NFIX WNK2

2.25e-03550726EFO_0004346, EFO_0004464

Protein segments in the cluster

PeptideGeneStartEntry
QEPLMSSRPPLPPPR

BANK1

501

Q8NDB2
PTPGRPLTPQPIQMP

GNAS

391

P84996
VRIPQMPAPPHPRTP

ADAMTSL4

646

Q6UY14
MEKNPREAPPVVPPL

BUB1

351

O43683
AGRPVMPPPQVPLPT

ABL2

1036

P42684
MIQSATPPPPTTRPP

ACR

296

P10323
MEDVRIHEPLPPPPP

ARHGEF5

716

Q12774
KRPAPARPTMPPPQV

SH3BP1

566

Q9Y3L3
MSIPQIRNPSLPPPE

DPYD

166

Q12882
SQVPPPEVRMTVPPL

ANKRD17

2126

O75179
TPLEPPPIVVVVMGP

BMS1

76

Q14692
PIPQPRLPTPTLEMT

CFAP91

471

Q7Z4T9
PVLVSVPMRLPLPPA

RASAL3

741

Q86YV0
PVPVPIPIPIPMPQS

RAI2

241

Q9Y5P3
PPRPEPPPGLMALEV

RBM42

326

Q9BTD8
QMEIPPVELPPEEPP

RAD21

496

O60216
MQPIPAPPVQRPSPA

KIAA1549

1491

Q9HCM3
EPPPPREPPLHMEPI

REST

796

Q13127
PTPQLLPPTERPMSP

CASKIN1

806

Q8WXD9
TITMIDRPPPPPPHI

PTPRB

1441

P23467
AMPVPIKPTPALPPV

FOXB2

361

Q5VYV0
MSAPPVLRPPSPLLP

PRKD1

1

Q15139
PPPVARPVPLPMPDS

NFIX

436

Q14938
DTELMPPPPPKRPRP

RNGTT

581

O60942
VPPPIPPDMPVVKEI

ENOX2

86

Q16206
PNPLPLRLPEMEPLV

PCM1

1901

Q15154
ALPMVTTAPPPLPRI

PNRC1

31

Q12796
KLRPPTPPMVILEPP

PDZD4

86

Q76G19
LTPDPEMEPPPKPPR

MICAL1

821

Q8TDZ2
ELRNQMAEPPPPEPP

GOLGA2

441

Q08379
MIPPSAQPPRTQTPP

EIF4G2

496

P78344
TPLQPPPPVQRVMDP

GORASP1

291

Q9BQQ3
PPREPPPQPIMPSVF

NUTM1

41

Q86Y26
CVSVRDRMVPPPPPP

PRTG

711

Q2VWP7
RPPTVPPPMQELPDL

RIMS1

11

Q86UR5
PPPTEIPERFIMPPD

CBLL1

211

Q75N03
PPPITPPPGHIIAQM

CBLL1

381

Q75N03
PPLQPPVDPVVKARM

OBSCN

511

Q5VST9
PTVAPPMVRPTPRPD

NID2

1086

Q14112
PMVRPTPRPDVTPPS

NID2

1091

Q14112
RKPTPIPIPPMVIGQ

PAPPA2

841

Q9BXP8
PKDIRLPPPMPPSER

CHERP

671

Q8IWX8
MVRPLNPRPLPPVVL

GFRA3

1

O60609
MQPPEIPAPAHRPPE

CCDC9

396

Q9Y3X0
PPSKMVLRIPHPIQP

GON4L

1031

Q3T8J9
PLAVLPMEPLPPEPV

C1orf127

531

Q8N9H9
PMEPLPPEPVRPAAL

C1orf127

536

Q8N9H9
IPQPPPLQGTEMLPP

FMN2

896

Q9NZ56
PPVAMLQIPVAPAVP

SCAF8

636

Q9UPN6
IYPLPEDPAIPMPPR

DYSF

1551

O75923
EMQQPSPPIPPVHPD

PIAS2

131

O75928
MPELPRTAKQPPVPP

RIN3

446

Q8TB24
SVPPRPLLPLQPGMP

MEGF6

31

O75095
VPRPMPLIQSIPTTP

TOGARAM2

171

Q6ZUX3
PPPAVPSVPPLVTSM

PRRC1

76

Q96M27
QPPREQPLPPAPLAM

RERE

911

Q9P2R6
PPPPPMPLQLEAHLR

PRR12

841

Q9ULL5
MPPPLPPTPDQVIVR

SF3A1

376

Q15459
VPRPPTMPPPVRTTV

SF3A1

576

Q15459
VRLPPGSVIAPMPPI

SF3A1

606

Q15459
PMPPIIHAPRINVVP

SF3A1

616

Q15459
PPIMAPRPPPMIVPT

SF3A1

636

Q15459
PRPPPMIVPTAFVPA

SF3A1

641

Q15459
MEEAVILPFRIPPPP

SHANK2

1381

Q9UPX8
IPMVTPPPPPVFSLL

CLCA4

286

Q14CN2
AEVMPQVRSPPLEPP

PNMA5

136

Q96PV4
RPPSVAPPPMVAEIP

YBX2

186

Q9Y2T7
VQPARTPPMLRPVDP

TNIK

576

Q9UKE5
TPPMLRPVDPQIPHL

TNIK

581

Q9UKE5
FDPPPHMRVPTIPPN

TLE1

421

Q04724
VPLQMPPTEIHPPCP

TEX13D

256

A0A0J9YY54
EPPMSLQREPPRPEP

UBN2

81

Q6ZU65
ARVPMFPVPLPPGPL

SEC16A

1966

O15027
PTTAIPAFPPVMVPP

TCERG1

351

O14776
TVAPVPDMVVPPPRE

WDR97

1516

A6NE52
EMRRQEPLPPPPPPS

WAS

306

P42768
SLPPPVMPPALPATV

YLPM1

541

P49750
LLPPPPPPPRMAEVE

TMEM222

11

Q9H0R3
PPVPRPGIPPMTQAQ

ZNF207

211

O43670
PMPDPVVPPVSLQDP

ZNF462

201

Q96JM2
HVPLMPPSPPSQVIP

WASF1

466

Q92558
VPPQMPPIPVVPPIT

WNK2

791

Q9Y3S1
PSREPPKMNPVVEPL

THAP4

411

Q8WY91
VLPIPVPIFVPVPMH

ZMYM3

866

Q14202