Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP-dependent activity

DNHD1 KIF27 HSPA4L ABCB5 KIF21A RNF213 CHD1 FANCM HELB ACSL3 ACSL4 ATP6V1H SHOC1 KIF14 MACF1 DNAH5 ATP2B1 DNAH9 HSPA4 TOP2A TOP2B

3.83e-0861416521GO:0140657
GeneOntologyMolecularFunctiontestosterone 16-alpha-hydroxylase activity

CYP3A4 CYP3A5 CYP3A43

2.20e-0641653GO:0008390
GeneOntologyMolecularFunctiontestosterone 6-beta-hydroxylase activity

CYP3A4 CYP3A5 CYP3A43

5.47e-0651653GO:0050649
GeneOntologyMolecularFunctionvitamin D 23-hydroxylase activity

CYP3A4 CYP3A5 CYP3A43

5.47e-0651653GO:0062179
GeneOntologyMolecularFunction1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity

CYP3A4 CYP3A5 CYP3A43

5.47e-0651653GO:0062181
GeneOntologyMolecularFunctionvitamin D3 25-hydroxylase activity

CYP3A4 CYP3A5 CYP3A43

1.09e-0561653GO:0030343
GeneOntologyMolecularFunctionvitamin D 24-hydroxylase activity

CYP3A4 CYP3A5 CYP3A43

1.09e-0561653GO:0070576
GeneOntologyMolecularFunctionATP hydrolysis activity

KIF27 ABCB5 KIF21A RNF213 CHD1 FANCM HELB ATP6V1H SHOC1 KIF14 MACF1 DNAH5 ATP2B1 DNAH9

1.86e-0544116514GO:0016887
GeneOntologyMolecularFunctionvitamin D 25-hydroxylase activity

CYP3A4 CYP3A5 CYP3A43

1.89e-0571653GO:0070643
GeneOntologyMolecularFunctionmicrotubule motor activity

DNHD1 KIF27 KIF21A KIF14 DNAH5 DNAH9

2.46e-05701656GO:0003777
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor

CYP3A4 CYP3A5 CYP3A43

3.01e-0581653GO:0033695
GeneOntologyMolecularFunctioncaffeine oxidase activity

CYP3A4 CYP3A5 CYP3A43

3.01e-0581653GO:0034875
GeneOntologyMolecularFunctionestrogen 2-hydroxylase activity

CYP3A4 CYP3A5 CYP3A43

3.01e-0581653GO:0101021
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNHD1 HOOK3 DNAH5 DNAH9

7.88e-05281654GO:0051959
GeneOntologyMolecularFunctionestrogen 16-alpha-hydroxylase activity

CYP3A4 CYP3A5 CYP3A43

8.71e-05111653GO:0101020
GeneOntologyMolecularFunctionretinoic acid 4-hydroxylase activity

CYP3A4 CYP3A5 CYP3A43

1.89e-04141653GO:0008401
GeneOntologyMolecularFunctionpalmitoyl-CoA ligase activity

ACSL3 ACSL4

2.03e-0431652GO:0090433
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH or CH2 groups

CYP3A4 CYP3A5 CYP3A43

2.34e-04151653GO:0016725
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNHD1 HOOK3 DNAH5 DNAH9

2.40e-04371654GO:0045505
GeneOntologyMolecularFunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

TOP2A TOP2B

4.03e-0441652GO:0003918
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNHD1 DNAH5 DNAH9

4.13e-04181653GO:0008569
GeneOntologyMolecularFunctioncytoskeletal motor activity

DNHD1 KIF27 KIF21A KIF14 DNAH5 DNAH9

4.47e-041181656GO:0003774
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

RRAS2 KIF27 ABCB5 KIF21A RNF213 CHD1 FANCM HELB ATP6V1H SHOC1 KIF14 MACF1 DNAH5 GNL1 ATP2B1 DNAH9

7.11e-0477516516GO:0017111
GeneOntologyMolecularFunctionpyrophosphatase activity

RRAS2 KIF27 ABCB5 KIF21A RNF213 CHD1 FANCM HELB ATP6V1H SHOC1 KIF14 MACF1 DNAH5 GNL1 ATP2B1 DNAH9

1.62e-0383916516GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

RRAS2 KIF27 ABCB5 KIF21A RNF213 CHD1 FANCM HELB ATP6V1H SHOC1 KIF14 MACF1 DNAH5 GNL1 ATP2B1 DNAH9

1.64e-0384016516GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

RRAS2 KIF27 ABCB5 KIF21A RNF213 CHD1 FANCM HELB ATP6V1H SHOC1 KIF14 MACF1 DNAH5 GNL1 ATP2B1 DNAH9

1.64e-0384016516GO:0016818
GeneOntologyMolecularFunctionDNA topoisomerase activity

TOP2A TOP2B

1.84e-0381652GO:0003916
GeneOntologyMolecularFunctionaryl hydrocarbon receptor binding

ARNT ARNT2

2.35e-0391652GO:0017162
GeneOntologyMolecularFunctionsteroid hydroxylase activity

CYP3A4 CYP3A5 CYP3A43

2.75e-03341653GO:0008395
GeneOntologyBiologicalProcessmicrotubule-based movement

DNHD1 STK36 IFT140 KIF27 COPG1 KIF21A COPG2 RFX3 MAPK8IP3 SYNE2 KIF14 TEKT1 CCR6 TRAK2 DNAH5 DNAH9

1.96e-0649316316GO:0007018
GeneOntologyBiologicalProcessalkaloid catabolic process

CYP3A4 CYP3A5 CYP3A43

4.79e-0651633GO:0009822
GeneOntologyBiologicalProcessmicrotubule-based transport

STK36 IFT140 KIF27 COPG1 COPG2 RFX3 MAPK8IP3 SYNE2 TRAK2 DNAH5 DNAH9

5.65e-0625316311GO:0099111
GeneOntologyBiologicalProcessresolution of meiotic recombination intermediates

FANCM SHOC1 TOP2A TOP2B

1.06e-05181634GO:0000712
GeneOntologyBiologicalProcessmicrotubule-based process

ROCK2 DNHD1 STK36 IFT140 KIF27 COPG1 KIF21A COPG2 RFX3 MAPK8IP3 SPICE1 HOOK3 SYNE2 CEP135 KIF14 TEKT1 MACF1 CCR6 TRAK2 DNAH5 DNAH9 GEN1

3.17e-05105816322GO:0007017
GeneOntologyBiologicalProcessalkaloid metabolic process

CYP3A4 CYP3A5 CYP3A43

3.93e-0591633GO:0009820
GeneOntologyBiologicalProcesslipid hydroxylation

CYP3A4 CYP3A5 CYP3A43

3.93e-0591633GO:0002933
GeneOntologyBiologicalProcesspositive regulation of single stranded viral RNA replication via double stranded DNA intermediate

TOP2A TOP2B

6.21e-0521632GO:0045870
GeneOntologyBiologicalProcessoxidative demethylation

CYP3A4 CYP3A5 CYP3A43

1.01e-04121633GO:0070989
GeneOntologyBiologicalProcessepithelial cilium movement involved in extracellular fluid movement

STK36 KIF27 RFX3 DNAH5 DNAH9

1.03e-04591635GO:0003351
GeneOntologyBiologicalProcessextracellular transport

STK36 KIF27 RFX3 DNAH5 DNAH9

1.30e-04621635GO:0006858
GeneOntologyBiologicalProcessintra-Golgi vesicle-mediated transport

COPG1 COPG2 COG8 COG6

1.63e-04351634GO:0006891
GeneOntologyBiologicalProcessDNA recombination

DCAF1 SLF1 FANCM HELB SHOC1 PRMT1 CCR6 MAD2L2 GEN1 TOP2A TOP2B

1.72e-0436816311GO:0006310
GeneOntologyBiologicalProcesscilium assembly

DNHD1 STK36 IFT140 RPGRIP1L KIF27 RFX3 CC2D2B SYNE2 CEP135 TEKT1 CPLANE1 DNAH5

2.21e-0444416312GO:0060271
HumanPhenoVentriculomegaly

CUL4B STK36 KRT5 FLNB IFT140 RRAS2 KRT14 RPGRIP1L ACADVL KIF21A RNF213 EXTL3 FANCM COG8 GPC3 COG6 FBXO28 CEP135 KIF14 MAD2L2 CPLANE1 POMK DNAH5 DNAH9 SEMA3E

1.34e-057906825HP:0002119
DomainCyt_P450_E_grp-II

CYP3A4 CYP3A5 CYP3A43

6.68e-0651653IPR002402
DomainCyt_P450_E_CYP3A

CYP3A4 CYP3A5 CYP3A43

1.33e-0561653IPR008072
DomainPrefoldin

KRT4 KRT14 KRT19 KIF21A CEP135 TRAK2

4.19e-05721656IPR009053
DomainCoatomer_g_Cpla

COPG1 COPG2

7.76e-0521652IPR032154
Domain-

TOP2A TOP2B

7.76e-05216523.40.50.670
DomainDTHCT

TOP2A TOP2B

7.76e-0521652IPR012542
DomainDNA_gyraseB

TOP2A TOP2B

7.76e-0521652PF00204
Domain-

COPG1 COPG2

7.76e-05216522.60.40.1480
Domain-

TOP2A TOP2B

7.76e-05216523.90.199.10
DomainTopoIIA_CS

TOP2A TOP2B

7.76e-0521652IPR018522
DomainCOP-gamma_platf

COPG1 COPG2

7.76e-0521652PF08752
DomainCoatomer_g_Cpla

COPG1 COPG2

7.76e-0521652PF16381
DomainCoatomer_gsu_app_Ig-like-sub

COPG1 COPG2

7.76e-0521652IPR013040
DomainTopo_IIA

TOP2A TOP2B

7.76e-0521652IPR001241
DomainDNA_topoisoIV

TOP2A TOP2B

7.76e-0521652PF00521
DomainDUF1712

CCZ1B CCZ1

7.76e-0521652PF08217
DomainTopo_IIA_A/C_ab

TOP2A TOP2B

7.76e-0521652IPR013758
DomainTopo_IIA_A_a

TOP2A TOP2B

7.76e-0521652IPR013757
DomainTopo_IIA_cen_dom

TOP2A TOP2B

7.76e-0521652IPR013759
DomainTOP4c

TOP2A TOP2B

7.76e-0521652SM00434
DomainTOP2c

TOP2A TOP2B

7.76e-0521652SM00433
DomainTopo_IIA-like_dom

TOP2A TOP2B

7.76e-0521652IPR013760
DomainTopo_IIA_bsu_dom2

TOP2A TOP2B

7.76e-0521652IPR013506
DomainDTHCT

TOP2A TOP2B

7.76e-0521652PF08070
Domain-

TOP2A TOP2B

7.76e-05216521.10.268.10
DomainTOPRIM_C

TOP2A TOP2B

7.76e-0521652IPR031660
DomainTOPRIM_C

TOP2A TOP2B

7.76e-0521652PF16898
DomainCoatomer_gsu

COPG1 COPG2

7.76e-0521652IPR017106
DomainDUF1712_fun

CCZ1B CCZ1

7.76e-0521652IPR013176
DomainTopo_IIA_A/C

TOP2A TOP2B

7.76e-0521652IPR002205
DomainTOPOISOMERASE_II

TOP2A TOP2B

7.76e-0521652PS00177
DomainCullin_repeat-like_dom

CUL4B CUL2 COG8

1.40e-04121653IPR016159
DomainDynein_HC_stalk

DNHD1 DNAH5 DNAH9

2.29e-04141653IPR024743
DomainDynein_heavy_dom-2

DNHD1 DNAH5 DNAH9

2.29e-04141653IPR013602
DomainDHC_N2

DNHD1 DNAH5 DNAH9

2.29e-04141653PF08393
DomainMT

DNHD1 DNAH5 DNAH9

2.29e-04141653PF12777
DomainArg_repress_C-like

TOP2A TOP2B

2.31e-0431652IPR024946
DomainSynapsin_pre-ATP-grasp_dom

SYN1 SYN2

2.31e-0431652IPR020897
DomainSynapsin_ATP-bd_dom

SYN1 SYN2

2.31e-0431652IPR020898
Domain-

TOP2A TOP2B

2.31e-04316523.30.1360.40
DomainSYNAPSIN_1

SYN1 SYN2

2.31e-0431652PS00415
DomainSYNAPSIN_2

SYN1 SYN2

2.31e-0431652PS00416
DomainSynapsin_C

SYN1 SYN2

2.31e-0431652PF02750
DomainSynapsin_N

SYN1 SYN2

2.31e-0431652PF10581
DomainSynapsin_CS

SYN1 SYN2

2.31e-0431652IPR019735
DomainSynapsin_P_site

SYN1 SYN2

2.31e-0431652IPR019736
DomainSynapsin

SYN1 SYN2

2.31e-0431652PF02078
DomainSynapsin

SYN1 SYN2

2.31e-0431652IPR001359
DomainCH

FLNB SYNE2 MACF1 MICAL3 ARHGEF6

2.73e-04651655SM00033
DomainDHC_fam

DNHD1 DNAH5 DNAH9

2.85e-04151653IPR026983
DomainDynein_heavy

DNHD1 DNAH5 DNAH9

2.85e-04151653PF03028
DomainDynein_heavy_dom

DNHD1 DNAH5 DNAH9

2.85e-04151653IPR004273
DomainCH

FLNB SYNE2 MACF1 MICAL3 ARHGEF6

3.86e-04701655PF00307
Domain-

FLNB SYNE2 MACF1 MICAL3 ARHGEF6

4.12e-047116551.10.418.10
DomainToprim

TOP2A TOP2B

4.60e-0441652PF01751
DomainClathrin_a/coatomer_app_sub_C

COPG1 COPG2

4.60e-0441652IPR015873
DomainToprim_domain

TOP2A TOP2B

4.60e-0441652IPR006171
DomainTOPRIM

TOP2A TOP2B

4.60e-0441652PS50880
Domain-

COPG1 COPG2

4.60e-04416523.30.310.30
DomainCH

FLNB SYNE2 MACF1 MICAL3 ARHGEF6

4.69e-04731655PS50021
DomainCH-domain

FLNB SYNE2 MACF1 MICAL3 ARHGEF6

5.31e-04751655IPR001715
DomainACTININ_2

FLNB SYNE2 MACF1

1.05e-03231653PS00020
DomainACTININ_1

FLNB SYNE2 MACF1

1.05e-03231653PS00019
DomainActinin_actin-bd_CS

FLNB SYNE2 MACF1

1.05e-03231653IPR001589
DomainPeptidase_M13_C

PHEX KEL

1.58e-0371652IPR018497
DomainPeptidase_M13

PHEX KEL

1.58e-0371652IPR000718
DomainPeptidase_M13_N

PHEX KEL

1.58e-0371652PF05649
DomainCullin_CS

CUL4B CUL2

1.58e-0371652IPR016157
DomainPeptidase_M13_N

PHEX KEL

1.58e-0371652IPR008753
DomainCULLIN

CUL4B CUL2

1.58e-0371652SM00182
DomainPeptidase_M13

PHEX KEL

1.58e-0371652PF01431
DomainCullin_neddylation_domain

CUL4B CUL2

2.10e-0381652IPR019559
DomainDHC_N1

DNAH5 DNAH9

2.10e-0381652PF08385
DomainNuc_translocat

ARNT ARNT2

2.10e-0381652IPR001067
DomainCullin_Nedd8

CUL4B CUL2

2.10e-0381652PF10557
DomainCoatomer/calthrin_app_sub_C

COPG1 COPG2

2.10e-0381652IPR009028
DomainCullin_Nedd8

CUL4B CUL2

2.10e-0381652SM00884
DomainDynein_heavy_dom-1

DNAH5 DNAH9

2.10e-0381652IPR013594
DomainIntermediate_filament_CS

KRT4 KRT5 KRT14 KRT19

2.33e-03631654IPR018039
DomainCullin_homology

CUL4B CUL2

2.68e-0391652IPR016158
DomainCullin

CUL4B CUL2

3.33e-03101652PF00888
DomainCULLIN_2

CUL4B CUL2

3.33e-03101652PS50069
DomainCullin_N

CUL4B CUL2

3.33e-03101652IPR001373
DomainCULLIN_1

CUL4B CUL2

3.33e-03101652PS01256
DomainP-loop_NTPase

DNHD1 RRAS2 KIF27 ABCB5 KIF21A RNF213 CARD10 CHD1 FANCM HELB KIF14 DLG3 CARD11 DNAH5 GNL1 DNAH9

3.50e-0384816516IPR027417
DomainIF

KRT4 KRT5 KRT14 KRT19

3.79e-03721654PS00226
DomainFilament

KRT4 KRT5 KRT14 KRT19

3.98e-03731654PF00038
DomainIF

KRT4 KRT5 KRT14 KRT19

4.60e-03761654IPR001664
Domain-

SKIL SP110

4.83e-031216523.10.390.10
DomainCoatomer/clathrin_app_Ig-like

COPG1 COPG2

4.83e-03121652IPR013041
Domain-

HSPA4L HSPA4

4.83e-031216522.60.34.10
DomainHSP70_peptide-bd

HSPA4L HSPA4

4.83e-03121652IPR029047
DomainSAND_dom-like

SKIL SP110

4.83e-03121652IPR010919
DomainKinesin_motor_CS

KIF27 KIF21A KIF14

5.64e-03411653IPR019821
Domain-

SYN1 SYN2

5.68e-031316523.40.50.20
Domain-

HSPA4L HSPA4

5.68e-031316521.20.1270.10
DomainHeat_shock_70_CS

HSPA4L HSPA4

5.68e-03131652IPR018181
DomainHSP70_C

HSPA4L HSPA4

5.68e-03131652IPR029048
DomainKinesin-like_fam

KIF27 KIF21A KIF14

6.45e-03431653IPR027640
DomainDynein_heavy_chain_D4_dom

DNAH5 DNAH9

6.58e-03141652IPR024317
PathwayREACTOME_XENOBIOTICS

CYP3A4 CYP3A5 CYP3A43 ARNT ARNT2

1.38e-06231235M5372
PathwayREACTOME_XENOBIOTICS

CYP3A4 CYP3A5 CYP3A43 ARNT ARNT2

2.15e-06251235MM14846
PathwayBIOCARTA_ACETAMINOPHEN_PATHWAY

CYP3A4 CYP3A5 CYP3A43

3.52e-0581233MM1547
PathwayKEGG_MEDICUS_PATHOGEN_HIV_VPR_TO_CDC25_CELL_CYCLE_G2M

CUL4B DCAF1 CCNB3

1.02e-04111233M47573
PathwayWP_NPHP1_DELETION_SYNDROME

FLNB RPGRIP1L MAPK3

1.02e-04111233M48099
PathwayREACTOME_BIOSYNTHESIS_OF_MARESINS

CYP3A4 CYP3A5 CYP3A43

1.35e-04121233MM15616
PathwayWP_TYPE_2_PAPILLARY_RENAL_CELL_CARCINOMA

CUL2 DVL2 ARNT ARNT2

2.09e-04341234M39771
PathwayWP_OMEGA9_FATTY_ACID_SYNTHESIS

ACSL3 ACSL4 ELOVL6

2.20e-04141233M39780
PathwayWP_OMEGA9_FATTY_ACID_SYNTHESIS

ACSL3 ACSL4 ELOVL6

2.20e-04141233MM15840
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP3A4 CYP3A5 CYP3A43 ARNT ARNT2

2.36e-04641235M5650
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP3A4 CYP3A5 CYP3A43 ARNT ARNT2

2.72e-04661235MM14839
PathwayREACTOME_ATORVASTATIN_ADME

CYP3A4 CYP3A5 CYP3A43

2.73e-04151233MM15697
PathwayWP_MITOCHONDRIAL_LONG_CHAIN_FATTY_ACID_BETAOXIDATION

ACADVL ACSL3 ACSL4

3.34e-04161233MM15841
PathwayWP_MITOCHONDRIAL_LONG_CHAIN_FATTY_ACID_BETAOXIDATION

ACADVL ACSL3 ACSL4

4.03e-04171233M39365
PathwayREACTOME_MISCELLANEOUS_SUBSTRATES

CYP3A4 CYP3A5 CYP3A43

4.81e-04181233MM14843
PathwayREACTOME_SEROTONIN_NEUROTRANSMITTER_RELEASE_CYCLE

PPFIA2 SYN1 SYN2

4.81e-04181233MM14702
PathwayREACTOME_SEROTONIN_NEUROTRANSMITTER_RELEASE_CYCLE

PPFIA2 SYN1 SYN2

4.81e-04181233M27043
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

CUL2 FLNB THOC7 COPG1 HSPA4L RNF213 COPG2 CARD10 TWF2 HMGCR ITPRID2 EXTL3 ADAM10 ARFGEF3 ACSL3 ATP6V1H HOOK3 COG6 SYNE2 PEX19 KIF14 PRMT1 MICAL3 CABIN1 ATP2B1 HSPA4 TOP2A TOP2B

3.37e-1014401682830833792
Pubmed

Joint effects of inflammation and androgen metabolism on prostate cancer severity.

CYP3A4 CYP3A5 CYP3A43 MSR1

1.82e-087168418566991
Pubmed

Immunolocalization patterns of cytokeratins during salivary acinar cell development in mice.

KRT4 KRT5 KRT14 KRT19

1.08e-0710168429181608
Pubmed

Liver maturation deficiency in p57(Kip2)-/- mice occurs in a hepatocytic p57(Kip2) expression-independent manner.

KRT19 CYP3A4 CYP3A5 CYP3A43

1.08e-0710168426165599
Pubmed

Downregulation of mouse hepatic CYP3A protein by 3-methylcholanthrene does not require cytochrome P450-dependent metabolism.

CYP3A4 CYP3A5 CYP3A43

1.11e-073168323846873
Pubmed

Regulation of the expression of two female-predominant CYP3A mRNAs (CYP3A41 and CYP3A44) in mouse liver by sex and growth hormones.

CYP3A4 CYP3A5 CYP3A43

1.11e-073168312147261
Pubmed

Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasone.

CYP3A4 CYP3A5 CYP3A43

1.11e-07316831339292
Pubmed

Predominantly neuronal expression of cytochrome P450 isoforms CYP3A11 and CYP3A13 in mouse brain.

CYP3A4 CYP3A5 CYP3A43

1.11e-073168312617959
Pubmed

Intergenic mRNA molecules resulting from trans-splicing.

CYP3A4 CYP3A5 CYP3A43

1.11e-073168311726664
Pubmed

High fat diet induced obesity is mitigated in Cyp3a-null female mice.

CYP3A4 CYP3A5 CYP3A43

1.11e-073168329738703
Pubmed

A novel female-specific member of the CYP3A gene subfamily in the mouse liver.

CYP3A4 CYP3A5 CYP3A43

1.11e-073168310775455
Pubmed

Concordant up-regulation of cytochrome P450 Cyp3a11, testosterone oxidation and androgen receptor expression in mouse brain after xenobiotic treatment.

CYP3A4 CYP3A5 CYP3A43

1.11e-073168319226368
Pubmed

Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation.

CYP3A4 CYP3A5 CYP3A43

1.11e-073168319188337
Pubmed

Human gut microbiota influences drug-metabolizing enzyme hepatic Cyp3a: A human flora-associated mice study.

CYP3A4 CYP3A5 CYP3A43

1.11e-073168337258238
Pubmed

Effect of Naringenin, Quercetin, and Sesamin on Xenobiotica-Metabolizing CYP1A and CYP3A in Mice Offspring after Maternal Exposure to Persistent Organic Pollutants.

CYP3A4 CYP3A5 CYP3A43

1.11e-073168328567424
Pubmed

A useful model capable of predicting the clearance of cytochrome 3A4 (CYP3A4) substrates in humans: validity of CYP3A4 transgenic mice lacking their own Cyp3a enzymes.

CYP3A4 CYP3A5 CYP3A43

1.11e-073168325005602
Pubmed

Cloning, sequencing, heterologous expression, and characterization of murine cytochrome P450 3a25*(Cyp3a25), a testosterone 6beta-hydroxylase.

CYP3A4 CYP3A5 CYP3A43

1.11e-073168311284050
Pubmed

Collaborated regulation of female-specific murine Cyp3a41 gene expression by growth and glucocorticoid hormones.

CYP3A4 CYP3A5 CYP3A43

1.11e-073168314733933
Pubmed

Genetic variations in androgen metabolism genes and associations with prostate cancer in South African men.

CYP3A4 CYP3A5 CYP3A43

1.11e-073168321081028
Pubmed

Mouse cytochrome P450 (Cyp3a11): predominant expression in liver and capacity to activate aflatoxin B1.

CYP3A4 CYP3A5 CYP3A43

1.11e-07316839143324
Pubmed

Lentiviral transgenic microRNA-based shRNA suppressed mouse cytochromosome P450 3A (CYP3A) expression in a dose-dependent and inheritable manner.

CYP3A4 CYP3A5 CYP3A43

1.11e-073168322291988
Pubmed

CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer.

CYP3A4 CYP3A5 CYP3A43

1.11e-073168315548719
Pubmed

CYP3A-mediated generation of aldehyde and hydrazine in atazanavir metabolism.

CYP3A4 CYP3A5 CYP3A43

1.11e-073168321148252
Pubmed

Different diets cause alterations in the enteric environment and trigger changes in the expression of hepatic cytochrome P450 3A, a drug-metabolizing enzyme.

CYP3A4 CYP3A5 CYP3A43

1.11e-073168323370405
Pubmed

Selective inactivation of mouse liver cytochrome P-450IIIA by cannabidiol.

CYP3A4 CYP3A5 CYP3A43

1.11e-07316832402224
Pubmed

Genetic analysis of sensitization and tolerance to cocaine.

CYP3A4 CYP3A5 CYP3A43

1.11e-07316837932176
Pubmed

Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism.

CYP3A4 CYP3A5 CYP3A43

1.11e-073168326212543
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

KRT5 KRT14 RPGRIP1L CCDC18 RNF213 COPG2 ITPRID2 SPICE1 ACSL3 ACSL4 PHKA1 PTPN14 SYNE2 CEP135 PEX19 PHLPP1 KIF14 MICAL3 MAPK3 ATP2B1

1.95e-0710491682027880917
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

KRT5 FGFR1OP2 RPGRIP1L ACADVL HSPA4L VPS13C POLG RNF213 CCDC90B ITPRID2 ARFGEF3 ACSL3 ACSL4 PTPN14 TRABD FBXO28 SYNE2 PEX19 CCDC25 TRAK2 SUCO GNL1 GEN1 TOP2A

2.56e-0714961682432877691
Pubmed

Hepatocyte nuclear factor 4α regulates expression of the mouse female-specific Cyp3a41 gene in the liver.

CYP3A4 CYP3A5 CYP3A43

4.41e-074168321088200
Pubmed

Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism.

CYP3A4 CYP3A5 CYP3A43

4.41e-074168336050438
Pubmed

A novel form of mouse cytochrome P450 3A (Cyp3a-16). Its cDNA cloning and expression in fetal liver.

CYP3A4 CYP3A5 CYP3A43

4.41e-07416837813478
Pubmed

Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism.

CYP3A4 CYP3A5 CYP3A43

4.41e-074168317975676
Pubmed

Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice.

CYP3A4 CYP3A5 CYP3A43

4.41e-074168331633069
Pubmed

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans.

CYP3A4 CYP3A5 CYP3A43

4.41e-074168327638959
Pubmed

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

CYP3A4 CYP3A5 CYP3A43

4.41e-074168310935643
Pubmed

Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver.

CYP3A4 CYP3A5 CYP3A43

4.41e-074168323709690
Pubmed

Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model.

CYP3A4 CYP3A5 CYP3A43

4.41e-074168326903378
Pubmed

iTAG-RNA Isolates Cell-Specific Transcriptional Responses to Environmental Stimuli and Identifies an RNA-Based Endocrine Axis.

CYP3A4 CYP3A5 CYP3A43

4.41e-074168332130917
Pubmed

CYP3A4 and pregnane X receptor humanized mice.

CYP3A4 CYP3A5 CYP3A43

4.41e-074168317936928
Pubmed

Genomic characterization and regulation of CYP3a13: role of xenobiotics and nuclear receptors.

CYP3A4 CYP3A5 CYP3A43

4.41e-074168312958193
Pubmed

Cytokeratin expression during mouse embryonic and early postnatal mammary gland development.

KRT5 KRT14 KRT19

4.41e-074168319937336
Pubmed

Unchanged cytochrome P450 3A (CYP3A) expression and metabolism of midazolam, triazolam, and dexamethasone in mdr(-/-) mouse liver microsomes.

CYP3A4 CYP3A5 CYP3A43

4.41e-074168310230766
Pubmed

Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration.

CYP3A4 CYP3A5 CYP3A43

4.41e-074168325319358
Pubmed

The transcription factor E4bp4 regulates the expression and activity of Cyp3a11 in mice.

CYP3A4 CYP3A5 CYP3A43

4.41e-074168330796914
Pubmed

Mouse aortic muscle cells respond to oxygen following cytochrome P450 3A13 gene transfer.

CYP3A4 CYP3A5 CYP3A43

4.41e-074168323656416
Pubmed

Molecular cloning and functional expression of a mouse cytochrome P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate aflatoxin B1 (AFB1).

CYP3A4 CYP3A5 CYP3A43

4.41e-07416837803471
Pubmed

A map of the mouse Cyp3a locus.

CYP3A4 CYP3A5 CYP3A43

4.41e-074168314509827
Pubmed

Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans.

CYP3A4 CYP3A5 CYP3A43

4.41e-074168323125282
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

ROCK2 EFCAB5 KRT5 FLNB KRT14 ACADVL KRT19 HSPA4L PPFIA2 ABCB5 KIF21A SIK1 PHEX ACSL3 ACSL4 CEP112 SYNE2 MACF1 DLG3 CADPS2 ATP2B1 TOP2A TOP2B

5.17e-0714421682335575683
Pubmed

Sterol 27-hydroxylase gene dosage and the antiatherosclerotic effect of Rifampicin in mice.

CYP3A4 CYP3A5 CYP3A43

1.10e-065168329191818
Pubmed

Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.

CYP3A4 CYP3A5 CYP3A43

1.10e-065168311266076
Pubmed

Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity.

CYP3A4 CYP3A5 CYP3A43

1.10e-065168319920203
Pubmed

Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures.

CYP3A4 CYP3A5 CYP3A43

1.10e-065168329125184
Pubmed

P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel.

CYP3A4 CYP3A5 CYP3A43

1.10e-065168323090875
Pubmed

Multiple cytochrome P450 isozymes in murine skin: induction of P450 1A, 2B, 2E, and 3A by dexamethasone.

CYP3A4 CYP3A5 CYP3A43

1.10e-06516838006463
Pubmed

Glycine N-methyltransferase inhibits aristolochic acid nephropathy by increasing CYP3A44 and decreasing NQO1 expression in female mouse hepatocytes.

CYP3A4 CYP3A5 CYP3A43

1.10e-065168329725048
Pubmed

Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes.

CYP3A4 CYP3A5 CYP3A43

1.10e-065168318156313
Pubmed

OATP1A/1B, CYP3A, ABCB1, and ABCG2 limit oral availability of the NTRK inhibitor larotrectinib, while ABCB1 and ABCG2 also restrict its brain accumulation.

CYP3A4 CYP3A5 CYP3A43

1.10e-065168332087611
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

KRT5 THOC7 KRT14 RPGRIP1L KRT19 ZNF507 TWF2 ITPRID2 ARFGEF3 ARNT PTPN14 KIF14 MACF1 MAD2L2

1.16e-065881681438580884
Pubmed

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.

CUL4B DOCK2 DCAF1 ROCK2 FLNB COPG2 HELB DNAH9 DCAF4

1.70e-06226168931452512
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

ROCK2 KRT5 FLNB KRT14 KRT19 HSPA4L PPFIA2 ARHGEF12 TWF2 NT5DC3 MAPK8IP3 ATP6V1H SYN1 SYN2 KCNQ3 MACF1 DLG3 MICAL3 LRRC7 MAPK3 ATP2B1 HSPA4

1.71e-0614311682237142655
Pubmed

Induction and genetic regulation of mouse hepatic cytochrome P450 by cannabidiol.

CYP3A4 CYP3A5 CYP3A43

2.19e-06616838043019
Pubmed

Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model.

CYP3A4 CYP3A5 CYP3A43

2.19e-066168326265742
Pubmed

Cytochrome P-450 3A13 and endothelin jointly mediate ductus arteriosus constriction to oxygen in mice.

CYP3A4 CYP3A5 CYP3A43

2.19e-066168321193583
Pubmed

Activated sterol regulatory element-binding protein-2 suppresses hepatocyte nuclear factor-4-mediated Cyp3a11 expression in mouse liver.

CYP3A4 CYP3A5 CYP3A43

2.19e-066168320926756
Pubmed

Individual and combined roles of CYP3A, P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel.

CYP3A4 CYP3A5 CYP3A43

2.19e-066168321351274
Pubmed

Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice.

CYP3A4 CYP3A5 CYP3A43

2.19e-066168322503787
Pubmed

Upregulation of CYP2e1 and CYP3a activities in histamine-deficient histidine decarboxylase gene targeted mice.

CYP3A4 CYP3A5 CYP3A43

2.19e-066168314642533
Pubmed

LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver.

CYP3A4 CYP3A5 CYP3A43

2.19e-066168315930522
Pubmed

Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation.

KRT5 KRT14 KRT19 GPC3 FGF7 MAPK3

2.79e-0681168639217171
Pubmed

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.

CUL4B DOCK2 KRT5 FLNB COPG1 ACADVL KRT19 RNF213 COPG2 ACSL3 FBXO28 KIF14 MACF1 PRMT1 MAPK3 TOP2A

3.75e-068441681625963833
Pubmed

The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons.

CYP3A4 CYP3A5 CYP3A43

3.82e-067168311137287
Pubmed

Cyp3a deficiency enhances androgen receptor activity and cholesterol synthesis in the mouse prostate.

CYP3A4 CYP3A5 CYP3A43

3.82e-067168327137100
Pubmed

Effects of infection of MRSA on the expression and activity of renal cytochrome P450s in mice.

CYP3A4 CYP3A5 CYP3A43

3.82e-067168330944282
Pubmed

Distinct stem cells contribute to mammary gland development and maintenance.

KRT5 KRT14 KRT19

3.82e-067168321983963
Pubmed

Cyp3a11-mediated testosterone-6β-hydroxylation decreased, while UGT1a9-mediated propofol O-glucuronidation increased, in mice with diabetes mellitus.

CYP3A4 CYP3A5 CYP3A43

3.82e-067168327514509
Pubmed

A novel transmembrane MSP-containing protein that plays a role in right ventricle development.

CYP3A4 CYP3A5 CYP3A43

3.82e-067168315533722
Pubmed

Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.

RPGRIP1L CCDC18 ARHGEF12 SPICE1 ARFGEF3 PHKA1 PTPN14 SYNE2 KIF14

4.01e-06251168929778605
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ITPRID2 MAPK8IP3 COG6 SYNE2 ARNT2 PHLPP1

4.24e-0687168612465718
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

CUL4B KRT5 RPGRIP1L KRT19 VPS13C ZNF507 DVL2 ATP6V1H PTPN14 HOOK3 CEP135 KIF14 MICAL3 CPLANE1 FHIP1A TOP2A

4.29e-068531681628718761
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

DCAF1 ROCK2 CUL2 FLNB RRAS2 COPG1 HSPA4L CHD1 TYK2 ACSL3 ATP6V1H PTPN14 PEX19 PRMT1 MAPK3 ATP2B1 HSPA4

5.50e-069741681728675297
Pubmed

Identification and characterization of human FNBP3 gene in silico.

CYP3A4 CYP3A5 CYP3A43

6.09e-068168312964049
Pubmed

Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis.

CYP3A4 CYP3A5 CYP3A43

6.09e-068168318488193
Pubmed

Lessons from keratin transgenic and knockout mice.

KRT5 KRT14 KRT19

6.09e-06816839932492
Pubmed

Intestinal cytochrome P450 3A plays an important role in the regulation of detoxifying systems in the liver.

CYP3A4 CYP3A5 CYP3A43

6.09e-068168318794335
Pubmed

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials.

CYP3A4 CYP3A5 CYP3A43

6.09e-068168330910785
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

ROCK2 CUL2 FLNB HSPA4L KIF21A DVL2 ACSL3 SYNE2 SYN1 MACF1 GNL1 TOP2A

6.12e-064981681236634849
Pubmed

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.

CUL4B CUL2 EFCAB5 FLNB RRAS2 COPG1 HSPA4L COPG2 ACSL3 ACSL4 ATP6V1H TRABD PRMT1 MAPK3 ATP2B1 HSPA4

6.16e-068781681637223481
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

RRAS2 HSPA4L PPFIA2 MAPK8IP3 SYN1 SYN2 MACF1 MICAL3 LRRC7 JPH3

8.01e-063471681017114649
Pubmed

Molecular Characterization of the Genital Organizer: Gene Expression Profile of the Mouse Urethral Plate Epithelium.

KRT19 CYP3A4 CYP3A5 CYP3A43

8.45e-0627168427173853
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

CUL4B DCAF1 IFT140 DVL2 L1TD1 RNF213 C16orf96 SKIL SP110 TYK2 PTPN14 ZNHIT6 CCNB3 TRABD TEKT1 MACF1 TOP2A UNC80

8.46e-0611161681831753913
Pubmed

Type II keratins precede type I keratins during early embryonic development.

KRT5 KRT14 KRT19

9.10e-069168316180309
Pubmed

Identification of genetic variants associated with response to statin therapy.

CYP3A4 CYP3A5 HMGCR

9.10e-069168319667110
Pubmed

Chromosomal assignments of genes coding for components of the mixed-function oxidase system in mice. Genetic localization of the cytochrome P-450PCN and P-450PB gene families and the nadph-cytochrome P-450 oxidoreductase and epoxide hydratase genes.

CYP3A4 CYP3A5 CYP3A43

9.10e-06916833917435
Pubmed

Family-based genome-wide association scan of attention-deficit/hyperactivity disorder.

SLC9A9 CEP112 ELOVL6

9.10e-069168320732626
Pubmed

The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature.

CYP3A4 CYP3A5 CYP3A43

9.10e-06916837678494
Pubmed

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.

IFT140 TWF2 RFX3 FREM2 CPLANE1 DNAH5

9.51e-06100168625807483
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

ROCK2 FLNB HSPA4L DVL2 ARHGEF12 COPG2 SPICE1 ATP6V1H MACF1 PRMT1 MICAL3 LRRC7 ATP2B1 HSPA4

9.72e-067081681439231216
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

KRT5 FLNB RRAS2 KRT14 ACADVL CHD1 ITPRID2 ACSL3 HOOK3 SYNE2 KIF14 MACF1 PRMT1 ATP2B1 HSPA4 TOP2A TOP2B

1.05e-0510241681724711643
InteractionPXN interactions

CCDC18 DVL2 ARHGEF12 ADAM10 NT5DC3 SPICE1 ARNT PTPN14 KIF14 MACF1 MAPK3 HSPA4 ARHGEF6

4.18e-0633416613int:PXN
InteractionSPAG5 interactions

RPGRIP1L KRT19 SPICE1 HOOK3 COG6 FBXO28 ARNT2 PHLPP1 KIF14 IQCE

5.14e-0619516610int:SPAG5
Cytoband7q21.1

CYP3A4 CYP3A5 CYP3A43

2.66e-06816837q21.1
GeneFamilyCytochrome P450 family 3

CYP3A4 CYP3A5 CYP3A43

1.30e-05811331002
GeneFamilySynapsins

SYN1 SYN2

1.16e-04311321325
GeneFamilyCalcium voltage-gated channel subunits|Membrane associated guanylate kinases

CARD10 DLG3 CARD11

5.57e-04261133904
GeneFamilyTopoisomerases

TOP2A TOP2B

5.71e-04611321050
GeneFamilyComponents of oligomeric golgi complex

COG8 COG6

1.06e-0381132493
GeneFamilyCullins

CUL4B CUL2

1.06e-03811321032
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

RPGRIP1L INPP4B CADPS2

1.46e-03361133823
GeneFamilyPDZ domain containing

DVL2 ARHGEF12 DLG3 CARD11 LRRC7

2.66e-0315211351220
GeneFamilyKinesins|Pleckstrin homology domain containing

KIF27 KIF21A KIF14

2.97e-03461133622
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

TYK2 PTPN14 FRMD6

3.76e-035011331293
GeneFamilyX-linked mental retardation|Angiotensin receptors

ACSL4 DLG3 ARHGEF6

4.44e-03531133103
GeneFamilyDyneins, axonemal

DNAH5 DNAH9

4.95e-03171132536
GeneFamilyHeat shock 70kDa proteins

HSPA4L HSPA4

4.95e-03171132583
GeneFamilyBasic helix-loop-helix proteins

OLIG3 ARNT ARNT2 OLIG2

5.02e-031101134420
GeneFamilyWD repeat domain containing|DDB1 and CUL4 associated factors

DCAF1 DCAF4

5.55e-03181132498
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

ROCK2 CUL2 FLNB RRAS2 CHD1 ADAM10 ACSL3 ACSL4 ATP6V1H ELL2 SYNE2 ARNT2 CEP135 PHLPP1 KIF14 MACF1 MICAL3 SUCO ATP2B1 TOP2A

6.56e-0785616820M4500
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

KRT14 PPFIA2 KIF21A MFSD6 SYT6 ITGA8 ARHGEF12 NT5DC3 MSR1 ARFGEF3 ACSL4 FRY ARNT2 KCNN3 SYN2 KCNQ3 DLG3 MICAL3 LRRC7 ATP2B1 CCDC144A JPH3 SEMA3E

6.79e-07110616823M39071
CoexpressionLAKE_ADULT_KIDNEY_C22_ENDOTHELIAL_CELLS_GLOMERULAR_CAPILLARIES

GPX3 ITGA8 ARHGEF12 RFX3 CEP112 SLCO2A1 MACF1 CADPS2

2.99e-061371688M39241
CoexpressionPYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_UP

FGFR1OP2 SLF1 KRT19 CCDC18 SIK1 SKIL SPICE1 SHOC1 GEN1

4.96e-061951689M13736
CoexpressionSAENZ_DETOX_PATHWAY_AND_CARCINOGENESIS_DN

CYP3A4 CYP3A5 CYP3A43 SLCO2A1

7.28e-06201684MM1104
CoexpressionGSE17721_LPS_VS_PAM3CSK4_1H_BMDC_DN

POLG ARHGEF12 ITPRID2 SKIL FRMD6 KCNN3 CADPS2 SEMA3E

4.52e-051991688M3912
CoexpressionGSE7460_TREG_VS_TCONV_ACT_WITH_TGFB_UP

HSPA4L NT5DC3 ANGPTL1 AXDND1 FRMD6 DLG3 CCR6 DNAH5

4.52e-051991688M5692
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

ROCK2 FLNB RRAS2 CHD1 ADAM10 ACSL3 CEP135 PHLPP1 KIF14 MICAL3 ATP2B1 TOP2A

5.02e-0546616812M13522
CoexpressionINAMURA_LUNG_CANCER_SCC_UP

KRT5 KRT14 TOP2A

7.06e-05131683M1253
CoexpressionBUSSLINGER_ESOPHAGEAL_PROLIFERATING_BASAL_CELLS

KRT5 KRT14 KRT19 SYNE2 TOP2A

8.81e-05701685M40002
CoexpressionHAMAI_APOPTOSIS_VIA_TRAIL_UP

CUL4B CUL2 SLF1 HSPA4L VPS13C L1TD1 CHD1 COG6 CEP112 SYNE2 KIF14 CPLANE1 SUCO TOP2B

8.99e-0565616814M18979
CoexpressionGSE8685_IL15_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP

DPY19L3 VPS13C CC2D2B ELL2 PHLPP1 ATP2B1 TOP2A

9.75e-051651687M337
CoexpressionLIN_MELANOMA_COPY_NUMBER_UP

POLG RNF213 COPG2 ARNT DNAH5

1.01e-04721685M346
CoexpressionGSE7509_UNSTIM_VS_FCGRIIB_STIM_MONOCYTE_DN

IFT140 POLG FRY CEP135 MACF1 MICAL3 CABIN1

1.01e-041661687M6826
CoexpressionNAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP

CUL4B CCZ1B FLNB THOC7 CCDC90B SIK1 HMGCR ADAM10 SP110 COG8 CCNG1 ACSL3 ACSL4 ZNHIT6 CCZ1 SYNE2 MACF1 OTULINL HSPA4 IQCE

1.07e-04121516820M41122
CoexpressionGSE3920_IFNA_VS_IFNB_TREATED_ENDOTHELIAL_CELL_UP

TRPM6 DPY19L3 TTBK1 SYNE2 MACF1 OTULINL ELOVL6

1.13e-041691687M6700
CoexpressionAtlasFacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3

ROCK2 VPS13C POLG KIF21A CCDC18 CHD1 FANCM RFX3 ACSL4 CEP135 SYN1 KIF14 MICAL3 GEN1 HSPA4

1.47e-0553216215Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000

ROCK2 HSPA4L KIF21A CCDC18 DVL2 CHD1 ADAM10 ACSL4 FREM2 SYNE2 CEP135 SYN1 KCNN3 PHLPP1 CCDC25 MICAL3 OLIG2 ATP2B1 GEN1 HSPA4 TOP2B

2.15e-0598916221Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

MROH9 SLC9A9 SYT6 ITGA8 MSR1 PHEX GPC3 MACF1 FGF7 CADPS2 SEMA3E

2.16e-101941681171d3c7448b1734de54187f902f65649f9283bd4c
ToppCellCOPD-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

RRAS2 KIF21A RFX3 ARFGEF3 KLRF1 SYNE2 CARD11 DNAH5 DNAH9 TOP2A

2.71e-0918816810186fe1ea328c942910190a4240262c0d8642ea3b
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MROH9 SLC9A9 ITGA8 MSR1 PHEX GPC3 MACF1 FGF7 CADPS2 SEMA3E

3.49e-09193168109f69edc97b868d23998abc98928a2e89a885ef8a
ToppCellMS-CD8-proli_CD4|MS / Condition, Cell_class and T cell subcluster

FLNB RPGRIP1L FANCM ZFY SPICE1 HELB ARNT2 MICAL3 CABIN1

1.98e-0817216890b6dd257110b3f17fa71ab18a165b091a9d5ae9a
ToppCellControl-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

RRAS2 KRT19 ARHGEF12 ARFGEF3 FREM2 SYNE2 ROS1 CADPS2 FHIP1A

5.12e-0819216891bfd022d5b87cf8a5d5069f559339a553a52a0a2
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

KRT19 ARHGEF12 ARFGEF3 CEP112 SYNE2 TEKT1 CADPS2 DNAH5 DNAH9

5.85e-081951689fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

KRT19 ARHGEF12 ARFGEF3 CEP112 SYNE2 TEKT1 CADPS2 DNAH5 DNAH9

5.85e-081951689eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

KRT19 ARHGEF12 ARFGEF3 SYNE2 TEKT1 MACF1 DNAH5 DNAH9 TOP2A

6.12e-0819616896d02d494196e3f857d53eea46d9419690d43beca
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

KRT19 ARHGEF12 ARFGEF3 SYNE2 TEKT1 MACF1 DNAH5 DNAH9 TOP2A

6.12e-081961689af4cdc61830685a888a1209826c23bcf54a43084
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / Treatment groups by lineage, cell group, cell type

KRT19 KIF21A ARFGEF3 ACSL4 TRABD SYNE2 GALNT5 CADPS2 FHIP1A

6.39e-0819716891a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLF1 PPFIA2 COPG2 FRY SYN2 KCNQ3 LRRC7 ATP2B1 UNC80

6.67e-0819816890ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

RNF213 CHD1 INPP4B HELB SYNE2 MACF1 PCNX1 CCDC144A

2.93e-0717116882e9a20f8980b78325c52065a9c14ab3656267c05
ToppCellControl-Epithelial_cells-Airway_club|Control / group, cell type (main and fine annotations)

FNIP2 ARFGEF3 FREM2 KCNQ3 ROS1 CADPS2 DNAH5 FHIP1A

4.51e-071811688c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCelldroplet-Marrow-nan-3m-Myeloid-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROCK2 VPS13C SIK1 CHD1 MSR1 MACF1 ATP2B1 TOP2B

4.71e-071821688f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK36 PPFIA2 ARFGEF3 FREM2 ROS1 DNAH5 DNAH9 UNC80

5.11e-0718416882cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK36 PPFIA2 ARFGEF3 FREM2 ROS1 DNAH5 DNAH9 UNC80

5.11e-0718416882b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK36 PPFIA2 ARFGEF3 FREM2 ROS1 DNAH5 DNAH9 UNC80

5.11e-071841688ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK36 KIF27 FREM2 FRMD6 TEKT1 DNAH5 DNAH9 FHIP1A

5.33e-07185168805bc89a566b0db90ae06506e067190a4739a0974
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RIN3 ITGA8 INPP4B MSR1 FGF7 LRRC7 CABIN1 SEMA3E

5.33e-0718516881ac6a32cc56d5d819649bdd99518e2ead0eead4c
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROCK2 VPS13C SIK1 CHD1 MSR1 MACF1 ATP2B1 TOP2B

5.33e-0718516887adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCellPND14-Epithelial-Epithelial_Airway|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIF27 KRT19 HSPA4L KIF21A TEKT1 DNAH5 DNAH9 SEMA3E

5.78e-0718716881399c703505211c510b3f14c7a2aa9930566c473
ToppCellFibroblast-A|World / shred on cell class and cell subclass (v4)

RRAS2 GPX3 ITGA8 BRINP1 PHEX GPC3 MACF1 FGF7

6.02e-0718816886740bed5fb8f45b6eea17041894b804214c2a4ae
ToppCellPND28-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RPGRIP1L KIF27 KRT19 HSPA4L KIF21A TEKT1 OSCP1 DNAH5

6.26e-071891688fa1ff8b7fa53f3148d9117d6e598097f03af5eb2
ToppCellLA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

ROCK2 FLNB PPFIA2 ITGA8 NT5DC3 INPP4B FRY MACF1

6.26e-0718916886b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCellPND28-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RPGRIP1L KIF27 KRT19 HSPA4L KIF21A TEKT1 OSCP1 DNAH5

6.26e-071891688565063f9e3dd79164321f8a394bd12c176baf202
ToppCellPND28-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RPGRIP1L KIF27 KRT19 HSPA4L KIF21A TEKT1 OSCP1 DNAH5

6.26e-071891688497be236848ebf5ad75d1f0c71e6261f5d3521da
ToppCellP07-Mesenchymal-mesenchymal_fibroblast|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RRAS2 GPX3 ITGA8 BRINP1 PHEX GPC3 MACF1 FGF7

6.78e-071911688a05e9a7eb137d804570dd7d8905975d735738767
ToppCellPND07-Epithelial-Epithelial_Airway|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KRT4 KRT5 KRT14 KRT19 HSPA4L C16orf96 TEKT1 DNAH5

6.78e-071911688b55500eb416f4f339031acad16b2737e5b891d8e
ToppCellP03-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RRAS2 GPX3 ITGA8 PHEX GPC3 MACF1 FGF7 MICAL3

7.05e-0719216882802fae55683345ff94a1ecf73b6fbee4f17481e
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ARFGEF3 ACSL4 FREM2 KCNQ3 ROS1 CADPS2 DNAH5 FHIP1A

7.05e-071921688cc9911e182a289779a2612bc213daae5607689e7
ToppCellP07-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RRAS2 GPX3 ITGA8 BRINP1 PHEX GPC3 MACF1 FGF7

7.05e-0719216880afb9dbe468e0be442c326e11c5fc0f699b32f23
ToppCellPND14-Mesenchymal-Mesenchymal_structural|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RRAS2 GPX3 ITGA8 BRINP1 PHEX GPC3 MACF1 FGF7

7.05e-07192168825492568f9cbe097b7bb1db50d8b817c80ea87d7
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RRAS2 GPX3 ITGA8 BRINP1 PHEX GPC3 MACF1 FGF7

7.05e-071921688de9c1536d5aee86f9c62acbc54ca8fa581c00f17
ToppCellEpithelial-club_cell|World / Lineage, Cell type, age group and donor

FNIP2 INPP4B ARFGEF3 PTPN14 CADPS2 DNAH5 FHIP1A SEMA3E

7.34e-0719316882bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RRAS2 GPX3 ITGA8 BRINP1 PHEX GPC3 MACF1 FGF7

7.34e-0719316888d05805295c5d3aa93aeb38be5fbefa81e1be1f0
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RRAS2 GPX3 ITGA8 BRINP1 PHEX GPC3 MACF1 FGF7

7.34e-0719316881b2cc627b2aa002b442358bd1188d470e67ce7d9
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RRAS2 GPX3 ITGA8 BRINP1 PHEX GPC3 MACF1 FGF7

7.93e-071951688cbe518b465b4ef32797ae6b608219207c08493df
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RRAS2 GPX3 ITGA8 BRINP1 PHEX GPC3 MACF1 FGF7

7.93e-071951688b616ee6f1d878935d293c8e0a8bbc5b4385301f0
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RRAS2 GPX3 ITGA8 BRINP1 PHEX GPC3 MACF1 FGF7

7.93e-0719516881c1135be421af98cd0077bec1ff2c4158d42aa21
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RRAS2 GPX3 ITGA8 BRINP1 PHEX GPC3 MACF1 FGF7

7.93e-0719516883a0cad69cfc150a27a0666f612f5294c817197d7
ToppCellPND10-Mesenchymal-Mesenchymal_structural|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RRAS2 GPX3 ITGA8 BRINP1 PHEX GPC3 MACF1 FGF7

7.93e-07195168811d421bbbb71425d59cbdd673e052e00d5f0a768
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RRAS2 GPX3 ITGA8 BRINP1 PHEX GPC3 MACF1 FGF7

7.93e-0719516882b8ee7990267bb52b7e6ae03f509ffebf8908122
ToppCellControl-Multiplet-Multiplet|Control / Disease state, Lineage and Cell class

RRAS2 KRT19 ARHGEF12 ARFGEF3 SYNE2 ROS1 CADPS2 FHIP1A

7.93e-07195168806ac685855e14e4dd2cbe6d0e73f894f2eeff91f
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RRAS2 GPX3 ITGA8 BRINP1 PHEX GPC3 MACF1 FGF7

7.93e-0719516881f005ee1da66b539bd200aaa98f46edbbc7f12e4
ToppCellPND07-Mesenchymal-Mesenchymal_structural|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RRAS2 GPX3 ITGA8 BRINP1 PHEX GPC3 MACF1 FGF7

7.93e-0719516882f9a274b26fc528a85f50933ec2f4db1dc9da0ca
ToppCellControl-Multiplet|Control / Disease state, Lineage and Cell class

RRAS2 KRT19 ARHGEF12 ARFGEF3 SYNE2 ROS1 CADPS2 FHIP1A

7.93e-071951688618900c80bea09d46dad3f741bd1bff8bf0a64ee
ToppCellPND03-Mesenchymal-Mesenchymal_structural|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RRAS2 GPX3 ITGA8 BRINP1 PHEX GPC3 MACF1 FGF7

7.93e-071951688136b06b0931a69b1241101f68c01c44c70365fd9
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RRAS2 GPX3 ITGA8 BRINP1 PHEX GPC3 MACF1 FGF7

7.93e-07195168810f307aef8f4d9e71c501d5bcedb84d3be7a4d1b
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROCK2 VPS13C GPX3 TMOD4 CHD1 ANGPTL1 ACSL3 CEP112

7.93e-0719516885c86fddd6d0530beecf45ea5ba6b823123847696
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RRAS2 GPX3 ITGA8 BRINP1 PHEX GPC3 MACF1 FGF7

8.24e-07196168814246f00c90741a5f8683f377e22e3a7c99661b9
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RRAS2 GPX3 ITGA8 BRINP1 PHEX GPC3 MACF1 FGF7

8.24e-0719616882a885eed52f9b002c7995e11e450c7e8d7ae69e6
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RPGRIP1L KIF27 RFX3 SYNE2 KCNN3 CPLANE1 DNAH5 DNAH9

8.56e-07197168874a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FLNB INPP4B ARFGEF3 PTPN14 SYNE2 DNAH5 FHIP1A SEMA3E

8.89e-0719816881408e02e053ad3406229bfe8189da03be6366e81
ToppCellLPS_only-Epithelial_airway-airway_epithelial-Ciliated|LPS_only / Treatment groups by lineage, cell group, cell type

STK36 KIF27 TEKT1 OSCP1 DNAH5 DNAH9 IQCE SEMA3E

8.89e-0719816886d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCellcellseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SERPINA3 GPX3 ITGA8 ANGPTL1 PHEX GPC3 MACF1 FGF7

8.89e-071981688f1374f7a50244d59c766ac41f44c08c9117407d2
ToppCellproximal-mesenchymal-Alveolar_Fibroblast|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SERPINA3 CYP3A5 GPX3 ITGA8 PHEX GPC3 MACF1 FGF7

9.24e-0719916887f4840ae6a888380feca722543e5e52783f3e35d
ToppCellproximal-3-mesenchymal-Alveolar_Fibroblast|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SERPINA3 CYP3A5 GPX3 ITGA8 PHEX GPC3 MACF1 FGF7

9.24e-071991688301d02bbb37e6f1d24b6e865bc3fe3e91260eb30
ToppCellproximal-mesenchymal-Alveolar_Fibroblast-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SERPINA3 CYP3A5 GPX3 ITGA8 PHEX GPC3 MACF1 FGF7

9.24e-0719916889a16e519fb0651a7c4d8e05b931df4fb3b0eb3d1
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Airway-Club|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

KRT4 SERPINA3 KRT19 SYT6 ARFGEF3 FREM2 TEKT1 DNAH5

9.24e-0719916888649c2380285a668782d75eb076ce548eed0911d
ToppCellLPS_IL1RA-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ROCK2 FLNB ARHGEF12 RNF213 ITPRID2 SYNE2 MACF1 MAPK3

9.59e-0720016885c092b2ecc081b5d04476c56333c338cd89ab984
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

SLF1 COPG2 FRY SYN2 KCNQ3 LRRC7 ATP2B1 UNC80

9.59e-07200168848d801219bc771d6c7e151dc88ca4c179988de85
ToppCellLPS_IL1RA-Endothelial-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ROCK2 FLNB ARHGEF12 RNF213 ITPRID2 SYNE2 MACF1 MAPK3

9.59e-07200168872ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ROCK2 FLNB SLF1 ARHGEF12 RNF213 ITPRID2 SYNE2 MACF1

9.59e-072001688dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

RNF213 CHD1 INPP4B HELB SYNE2 MACF1 PCNX1

2.18e-0615616871545169694f686d28648a68b552c2ae606599d66
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC9A9 RIN3 TLR10 FRY CARD11 OTULINL ARHGEF6

3.29e-06166168763dc58864268b4e7779e4c45155022556fc634f9
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCDC18 ITGA8 GPC3 CEP112 KIF14 GEN1 TOP2A

3.70e-061691687563c267edaade0e5df192ad953801ef9768d4270
ToppCellLPS-antiTNF-Lymphocytic_B-B_cells-B-cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK2 PPFIA2 ANGPTL1 TLR10 CARD11 CCR6 GEN1

4.49e-0617416879eb3504f9340517ef5d056503044fbdb9ffeb714
ToppCellLPS-antiTNF-Lymphocytic_B|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK2 PPFIA2 ANGPTL1 TLR10 CARD11 CCR6 GEN1

4.49e-061741687cc493654ea3517bc6a145c7f787f304929636f86
ToppCellP15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RRAS2 GPX3 ITGA8 PHEX GPC3 MACF1 FGF7

4.49e-0617416873c47d069bd836599a8d40eae485c23d4d3487517
ToppCellLPS-antiTNF-Lymphocytic_B-B_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK2 PPFIA2 ANGPTL1 TLR10 CARD11 CCR6 GEN1

4.49e-061741687b4c2d1c029fcd0d4926aa79a5b789c713919dcf3
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RRAS2 TMOD4 PHEX GPC3 MACF1 KEL GALNT5

4.84e-061761687d30241fb8119834d6e7b59efec3f92fc7a3d1247
ToppCellCOVID-19-B_cells-Activated_B_cells|COVID-19 / group, cell type (main and fine annotations)

DOCK2 SP110 ANGPTL1 TLR10 CARD11 MICAL3 ATP2B1

5.02e-061771687653bb62a3744d4024ab3186ee01d410ed62832a6
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIF21A ARFGEF3 ACSL4 SYNE2 GALNT5 CADPS2 FHIP1A

5.40e-061791687fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCellMatrixFB-Fibroblast-A|MatrixFB / shred on cell class and cell subclass (v4)

RRAS2 VPS13C GPX3 BRINP1 PHEX GPC3 MACF1

5.61e-061801687adc64ad6033af705dd7b9163a83e20ef5c59f6eb
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

KRT4 FLNB INPP4B ARFGEF3 PTPN14 DNAH5 SEMA3E

6.03e-061821687215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KRT19 KIF21A ACSL4 ROS1 GALNT5 CADPS2 FHIP1A

6.03e-06182168717ed11a7ea366dd3106400511d5e628d3f1a9c3e
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ARHGEF12 FREM2 PTPN14 CADPS2 DNAH5 FHIP1A SEMA3E

6.47e-061841687102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIF21A ARFGEF3 ACSL4 ROS1 GALNT5 CADPS2 FHIP1A

6.47e-061841687ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCellIPF-Epithelial-ATII|IPF / Disease state, Lineage and Cell class

KRT19 ARFGEF3 FREM2 KCNQ3 ROS1 CADPS2 FHIP1A

6.71e-061851687563b4e6d92bb5d77a3829556116a8e99aebac615
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

GPX3 ITGA8 INPP4B MSR1 FGF7 UNC80 SEMA3E

6.71e-0618516879f19f04fc4d97dfc2dd78cde77b515f1cb5d51ec
ToppCellIPF-Epithelial-ATII|World / Disease state, Lineage and Cell class

KRT19 ARFGEF3 FREM2 KCNQ3 ROS1 CADPS2 FHIP1A

6.95e-0618616876a4ff2da0af0f5e590d9f9daa5b5e9ac8c868947
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIF21A ARFGEF3 ACSL4 ROS1 GALNT5 CADPS2 FHIP1A

6.95e-061861687e83718fabb057100835d3357df407f283d23fe16
ToppCellfacs-Lung-EPCAM-3m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPGRIP1L KIF27 KIF21A TEKT1 DNAH5 DNAH9 SEMA3E

7.20e-06187168704dba2ed09ee4180830bdf0191921696697ea234
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SLC9A9 ITGA8 INPP4B MSR1 FGF7 UNC80 SEMA3E

7.20e-06187168713731298bc562ec29582f5da1b4c97261284f6f1
ToppCellControl-T_cells|Control / group, cell type (main and fine annotations)

DOCK2 INPP4B HELB KLRF1 SYNE2 PCNX1 CARD11

7.20e-061871687f4e8e0eba58da89b56587667555a5d4754e108c7
ToppCellfacs-Lung-EPCAM-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPGRIP1L KIF27 KIF21A TEKT1 DNAH5 DNAH9 SEMA3E

7.20e-061871687805dafe22f835ece4dd091d8030d0a63b52a48dd
ToppCellCOVID-19-Epithelial_cells-Airway_basal|COVID-19 / group, cell type (main and fine annotations)

TRPM6 KRT5 KRT19 ARFGEF3 PTPN14 DNAH5 FHIP1A

7.20e-0618716878407a82e98f56a94ea26562bcb6bbe00a8f41661
ToppCellP15-Mesenchymal|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RRAS2 GPX3 ITGA8 GPC3 MACF1 FGF7 OTULINL

7.45e-061881687f1ba0b661621a65c91432e62ba73531bdf18e7c1
ToppCellEpithelial-Epithelial-D_(Ciliated)|Epithelial / shred on cell class and cell subclass (v4)

RPGRIP1L SLF1 KIF27 HSPA4L TEKT1 DNAH5 DNAH9

7.45e-0618816878f30535a32968a81a304315a49c0d90a77d36948
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

VPS13C RNF213 CHD1 SYNE2 MACF1 PCNX1 SUCO

7.45e-061881687ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellPND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIF27 HSPA4L KIF21A C16orf96 TEKT1 DNAH5 DNAH9

7.71e-06189168702c6128a9ab5818e0881dcadafdad5f08b9a67cf
ToppCellPND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIF27 HSPA4L KIF21A C16orf96 TEKT1 DNAH5 DNAH9

7.71e-061891687164ea92ff6a1aa2ead1c9b8f64f99a9d65437232
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ACSL4 PTPN14 SYNE2 ARNT2 MICAL3 DNAH5 FHIP1A

7.71e-0618916878c8ca3b30d9be6c854615459a7bfba82b427c8bc
ToppCellPND10-Epithelial-Epithelial_Airway|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIF27 KRT19 HSPA4L KIF21A TEKT1 DNAH5 DNAH9

7.71e-061891687407d8a59969d83f014600aae1a55092283a13970
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ACSL4 PTPN14 SYNE2 ARNT2 MICAL3 DNAH5 FHIP1A

7.71e-0618916875d902a4660a27548764bf04c6de152b565da835c
ToppCellControl-Epithelial-ATII|Control / Disease state, Lineage and Cell class

KRT19 ARFGEF3 FREM2 KCNQ3 ROS1 CADPS2 FHIP1A

7.98e-061901687d50902a3abcc18aafa36d83cc2c6e07d7f7cb197
ToppCellPND14-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIF27 HSPA4L KIF21A TEKT1 DNAH5 DNAH9 SEMA3E

7.98e-06190168735248a8be476ea8d06d67c3d98a25be1f7c150b7
ToppCellPND14-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIF27 HSPA4L KIF21A TEKT1 DNAH5 DNAH9 SEMA3E

7.98e-0619016875f5206f9e725070d865f4c891ff08bb750e58582
ToppCellRV-15._Ventricular_Cardiomyocyte_III|RV / Chamber and Cluster_Paper

FNIP2 RRAS2 ARHGEF12 MAPK8IP3 ELL2 MICAL3 FHIP1A

7.98e-06190168793c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCellPND14-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIF27 HSPA4L KIF21A TEKT1 DNAH5 DNAH9 SEMA3E

7.98e-061901687088e3f39a1e5e11354d6e7458e8e6a39f14936b3
ComputationalGenes in the cancer module 68.

KRT4 KRT5 KRT14 KRT19

9.73e-05261024MODULE_68
ComputationalKeratin.

KRT4 KRT5 KRT14 KRT19

9.73e-05261024MODULE_298
Drugobeticholic acid

RRAS2 CYP3A4 CYP3A5 CYP3A43 GPX3 HMGCR TYK2 ACSL4 PRMT1 ROS1 MAPK3 ELOVL6

1.28e-0628316712ctd:C464660
Drugolomoucine II

KRT4 KRT5 KRT14 KRT19 HSPA4

1.42e-06271675CID005494414
Drugeucalyptol

CYP3A4 CYP3A5 HMGCR

1.54e-0641673ctd:C010087
Drugazidopine

CYP3A4 CYP3A5 ABCB5 CABIN1 TOP2B

1.71e-06281675CID000656406
Drugnaphthoquinone

SERPINA3 CYP3A4 CYP3A5 HMGCR MAPK3 ELOVL6 TOP2B

2.04e-06801677CID000008530
DrugVelcade (bortezomib

KRT4 KRT5 KRT14 KRT19 CYP3A4 CYP3A5 CCNG1 CCNB3 FGF7 CCR6 MAPK3 HSPA4 TOP2B

4.13e-0637416713CID000093860
DrugAC1L1SX8

CYP3A4 CYP3A5 CYP3A43 ABCB5

7.89e-06181674CID000060278
Druglovastatin acid

CYP3A4 ABCB5 HMGCR SYNE2

1.23e-05201674CID000064727
DrugDigocin

CYP3A4 CYP3A5 ABCB5 HMGCR SLCO2A1 TOP2B

1.27e-05701676CID000003062
Drug4-phenylbutyl isothiocyanate

CYP3A4 CYP3A5 MAPK3

1.33e-0571673CID000124881
Drugpyrazoloacridine

ABCB5 EXTL3 FGF7 TOP2B

1.84e-05221674CID005351360
DrugtBCEU

CYP3A5 ABCB5 TOP2B

2.11e-0581673CID000164059
DrugR7 1

CYP3A4 CYP3A5 HMGCR

2.11e-0581673CID000001949
DrugOC144-093

CYP3A4 ABCB5 KEL

2.11e-0581673CID006450807
Drugprobenecid

CYP3A4 CYP3A5 ABCB5 SLCO2A1 KEL OSCP1 TOP2B

3.50e-051231677CID000004911
DrugAC1NOLIT

CYP3A4 CYP3A5 MAPK3

4.48e-05101673CID005090286
DrugAC1L2XOG

CYP3A4 CYP3A5 ABCB5

4.48e-05101673CID000130599
Drugalternariol monomethyl ether

ARNT TOP2A TOP2B

4.48e-05101673ctd:C018206
DrugEpirubicin

CHD1 TOP2A

5.35e-0521672DB00445
Drug4-hydroxymidazolam

CYP3A4 CYP3A5

5.35e-0521672ctd:C042940
DrugDexrazoxane

TOP2A TOP2B

5.35e-0521672DB00380
Drugnorverapamil

CYP3A4 CYP3A5

5.35e-0521672ctd:C016904
Drug5,6-dihydro-2H-pyran-2-one

CYP3A4 CYP3A5

5.35e-0521672CID000520660
Drugnotopterol

CYP3A4 CYP3A5

5.35e-0521672CID005320227
DrugN-acetyl-S--(1,2,3,4,4-pentachlorobutadienyl)cysteine sulfoxide

CYP3A4 CYP3A5

5.35e-0521672ctd:C114289
DrugF14512

TOP2A TOP2B

5.35e-0521672ctd:C534191
DrugDaunorubicin

TOP2A TOP2B

5.35e-0521672DB00694
Drug6 beta-hydroxytestosterone

CYP3A4 CYP3A5

5.35e-0521672ctd:C025591
DrugCQA 206-291

CYP3A4 CYP3A5

5.35e-0521672ctd:C059483
Drugfructus schizandrae, radix ginseng, radix ophiopogonis drug combination

CYP3A4 CYP3A5

5.35e-0521672ctd:C009252
DrugSR-12813

CYP3A4 CYP3A5 ABCB5 HMGCR

5.75e-05291674CID000446313
Drugellipticine

CYP3A4 MAPK3 TOP2A TOP2B

5.75e-05291674ctd:C034192
Drugbifonazole

CYP3A4 CYP3A5 HMGCR

6.12e-05111673CID000002378
DrugAC1L7R8G

CYP3A4 CYP3A5 POLG

8.12e-05121673CID000315219
Drug7-hydroxyellipticine

CYP3A4 CYP3A5 TOP2B

8.12e-05121673CID000125663
Drug1,3-dimethylpurine-2,6,8-trione

CYP3A4 CYP3A5 KEL

8.12e-05121673CID014754220
DrugSanguinarine [2447-54-3]; Down 200; 12uM; MCF7; HT_HG-U133A

CUL2 FLNB VPS13C POLG ADAM10 SYNE2 MACF1 MICAL3

8.61e-0519116784168_DN
Drug4-Aminopyridine

SYN1 GALNT5 MAPK3 JPH3

9.68e-05331674ctd:D015761
Drugdiflomotecan

CYP3A4 CYP3A5 ABCB5 FGF7

9.68e-05331674CID000219023
DrugGallamine triethiodide [65-29-2]; Up 200; 4.4uM; MCF7; HT_HG-U133A

CUL4B DCAF1 KRT4 IFT140 MAPK8IP3 PCNX1 ARHGEF6 IQCE

9.94e-0519516786215_UP
DrugAconitine [302-27-2]; Down 200; 6.2uM; MCF7; HT_HG-U133A

RIN3 RPGRIP1L CYP3A4 SIK1 SKIL ADAM10 MAPK8IP3 TRABD

9.94e-0519516782776_DN
DrugDiethylcarbamazine citrate [1642-54-2]; Up 200; 10.2uM; HL60; HT_HG-U133A

ROCK2 CYP3A5 ARHGEF12 MAPK8IP3 SLCO2A1 MACF1 DCAF4 IQCE

9.94e-0519516782394_UP
Drug6-Furfurylaminopurine [525-79-1]; Down 200; 18.6uM; HL60; HT_HG-U133A

FLNB ITPRID2 SKIL ADAM10 FRY TRABD MACF1 PCNX1

1.03e-0419616782511_DN
DrugTHDCA

CYP3A4 CYP3A5 ABCB5

1.05e-04131673CID000119046
DrugSolasodine [126-17-0]; Up 200; 9.6uM; PC3; HT_HG-U133A

IFT140 CYP3A5 ITGA8 BRINP1 SP110 MAPK8IP3 PHEX ARNT

1.11e-0419816783749_UP
DrugPHA-00851261E [724719-49-7]; Up 200; 1uM; PC3; HT_HG-U133A

ITGA8 MAPK8IP3 KLRF1 PRDM11 GPC3 SLCO2A1 ELOVL6 CADPS2

1.18e-0420016783776_UP
DrugAC1L85AO

CYP3A4 CYP3A5 ABCB5 CABIN1 TOP2B

1.24e-04661675CID000372705
DrugTetracycline

TRPM6 SERPINA3 ACADVL CYP3A4 ABCB5 GPX3 DVL2 HMGCR TYK2 CCNG1 ARNT CCNB3 MAPK3 ELOVL6 TOP2A

1.26e-0466816715ctd:D013752
Drug9-hydroxyellipticine

CYP3A4 CYP3A5 TOP2B

1.33e-04141673CID000091643
DrugAD 288

ABCB5 MAPK3 TOP2B

1.33e-04141673CID000073553
Drugtroglitazone

CYP3A4 HSPA4L CYP3A5 ABCB5 MSR1 CCNG1 ACSL4 CCNB3 FGF7 MAPK3 ELOVL6 HSPA4 TOP2B

1.42e-0452616713CID000005591
Drughypericin

CYP3A4 CYP3A5 CYP3A43 ABCB5 PHEX MAPK3

1.47e-041081676CID005281051
Drugsatraplatin

CYP3A4 EXTL3 FGF7 CABIN1

1.53e-04371674CID006918220
Drugerythralosamine

CYP3A4 CYP3A5

1.60e-0431672CID000352196
Drug3-methoxymorphinan

CYP3A4 CYP3A5

1.60e-0431672ctd:C028657
Drugfluoroanilinoazatoxin

ABCB5 TOP2B

1.60e-0431672CID000378896
Drugdechloroethylcyclophosphamide

CYP3A4 CYP3A5

1.60e-0431672ctd:C064445
Drug6 beta-hydroxydexamethasone

CYP3A4 CYP3A5

1.60e-0431672CID000063050
Drugterritrem C

CYP3A4 CYP3A5

1.60e-0431672CID000160306
DrugNSC688503

ABCB5 TOP2B

1.60e-0431672CID000390744
DrugCp-100356

CYP3A4 ABCB5

1.60e-0431672CID000196918
DrugBIBW22BS

ABCB5 TOP2B

1.60e-0431672CID000132088
Drugtryptophan ethyl ester

KRT4 KRT5

1.60e-0431672CID000081996
DrugR101933

CYP3A4 ABCB5

1.60e-0431672CID000219080
Drughispidulin

SYN1 MAPK3

1.60e-0431672ctd:C055957
Drugmethylazatoxin

ABCB5 TOP2B

1.60e-0431672CID000148162
Drug1-hydroxymethylmidazolam

CYP3A4 CYP3A5

1.60e-0431672ctd:C040081
Drug9-hydroxyellipticine

CYP3A4 TOP2A

1.60e-0431672ctd:C008009
DrugWp159

ABCB5 TOP2B

1.60e-0431672CID003060549
DrugN-acetyl-S-pentachloro-1,3-butadienylcysteine

CYP3A4 CYP3A5

1.60e-0431672ctd:C049739
Diseasenon-syndromic X-linked intellectual disability (implicated_via_orthology)

ACSL3 ACSL4 DLG3

1.38e-0591643DOID:0050776 (implicated_via_orthology)
DiseaseEpidermolysis bullosa simplex 1A, generalized severe

KRT5 KRT14

3.07e-0521642cv:C0079295
DiseaseEpidermolysis bullosa simplex

KRT5 KRT14

3.07e-0521642cv:C0079298
DiseaseEpidermolysis bullosa simplex with mottled pigmentation

KRT5 KRT14

3.07e-0521642C0432316
Diseaseepidermolysis bullosa simplex Dowling-Meara type (implicated_via_orthology)

KRT5 KRT14

3.07e-0521642DOID:0060735 (implicated_via_orthology)
DiseaseEPIDERMOLYSIS BULLOSA SIMPLEX 1A, GENERALIZED SEVERE

KRT5 KRT14

3.07e-0521642131760
DiseaseEPIDERMOLYSIS BULLOSA SIMPLEX, AUTOSOMAL RECESSIVE 1

KRT5 KRT14

3.07e-0521642C3715082
DiseaseB cell deficiency (implicated_via_orthology)

TOP2A TOP2B

3.07e-0521642DOID:2115 (implicated_via_orthology)
Diseasenon-syndromic X-linked intellectual disability 63 (implicated_via_orthology)

ACSL3 ACSL4

3.07e-0521642DOID:0112050 (implicated_via_orthology)
DiseaseMalignant neoplasm of breast

KRT5 FLNB KRT14 CYP3A4 EFCAB13 ADAM10 SP110 INPP4B PTPN14 HOOK3 SPATA21 SYNE2 MACF1 LRRC7 GALNT5 DNAH9 GEN1 TOP2A

3.20e-05107416418C0006142
DiseaseMental Retardation, X-Linked Nonsyndromic

ACSL4 DLG3 ARHGEF6

4.63e-05131643C3501611
DiseaseEPIDERMOLYSIS BULLOSA SIMPLEX, AUTOSOMAL RECESSIVE (disorder)

KRT5 KRT14

9.18e-0531642C1832926
DiseaseEpidermolysis Bullosa Herpetiformis Dowling-Meara

KRT5 KRT14

9.18e-0531642C0079295
DiseaseEpidermolysis Bullosa Simplex Kobner

KRT5 KRT14

9.18e-0531642C0079299
DiseaseWeber-Cockayne Syndrome

KRT5 KRT14

9.18e-0531642C0080333
DiseasePrimary Ciliary Dyskinesia

STK36 RPGRIP1L DNAH5 DNAH9

1.36e-04471644C4551720
Diseasemetabolonic lactone sulfate measurement

CYP3A4 CYP3A5 CYP3A43

1.53e-04191643EFO_0800659
Diseasehydrocephalus (implicated_via_orthology)

STK36 KIF27 POMK

1.53e-04191643DOID:10908 (implicated_via_orthology)
DiseaseDowling-Degos disease 1

KRT5 ADAM10

1.83e-0441642C4552092
Diseasenon-obstructive coronary artery disease

PHLPP1 ATP2B1

1.83e-0441642EFO_1001483
DiseaseReticulate acropigmentation of Kitamura

KRT5 ADAM10

1.83e-0441642C0406811
Diseasetacrolimus measurement

CYP3A4 CYP3A5

1.83e-0441642EFO_0008458
DiseaseEpidermolysis Bullosa

KRT5 KRT14

1.83e-0441642C0014527
Diseaseautism spectrum disorder (implicated_via_orthology)

SLC9A9 CHD1 BRINP1 SYN1 SYN2 CADPS2

2.14e-041521646DOID:0060041 (implicated_via_orthology)
Diseasedowling-degos disease

KRT5 ADAM10

3.04e-0451642C3714534
DiseaseEpidermolysis Bullosa Simplex

KRT5 KRT14

3.04e-0451642C0079298
Diseasecerebellar ataxia (is_implicated_in)

RPGRIP1L POLG

3.04e-0451642DOID:0050753 (is_implicated_in)
DiseaseCongenital muscular dystrophy (disorder)

SYNE2 POMK

4.54e-0461642C0699743
DiseaseSjogren-Larsson syndrome (implicated_via_orthology)

ACSL3 ACSL4

4.54e-0461642DOID:14501 (implicated_via_orthology)
DiseaseIschemic stroke

TMOD4 MSR1 TTBK1 ZNHIT6 ARNT2 PCNX1 ATP2B1 JPH3

4.81e-043241648HP_0002140
DiseasePolydactyly

IFT140 RPGRIP1L FREM2 GPC3 CPLANE1

5.06e-041171645C0152427
Diseaseintellectual disability (is_implicated_in)

RPGRIP1L ACSL4 ARHGEF6

6.13e-04301643DOID:1059 (is_implicated_in)
Diseaseepidermolysis bullosa simplex (is_implicated_in)

KRT5 KRT14

6.33e-0471642DOID:4644 (is_implicated_in)
DiseaseLarge cell carcinoma of lung

TRPM6 TTBK1 ROS1

7.43e-04321643C0345958
DiseaseMental Retardation, X-Linked 1

ACSL4 DLG3 ARHGEF6

7.43e-04321643C2931498
Diseaseeosinophil percentage of leukocytes

CUL2 RIN3 KIF27 CCDC18 C16orf96 CHD1 COG6 TRABD CARD11 OTULINL OLIG2 DCAF4

9.92e-0474616412EFO_0007991
Diseaseadult respiratory distress syndrome (implicated_via_orthology)

SERPINA3 HSPA4

1.08e-0391642DOID:11394 (implicated_via_orthology)
Diseaselung cancer (is_marker_for)

GPX3 CCNG1 ACSL3

1.33e-03391643DOID:1324 (is_marker_for)
Diseaseciliopathy (implicated_via_orthology)

RPGRIP1L CC2D2B TEKT1

1.43e-03401643DOID:0060340 (implicated_via_orthology)
Diseasetriglyceride measurement, very low density lipoprotein cholesterol measurement

RRAS2 HMGCR ADAM10 TRABD SYNE2 MACF1

1.63e-032241646EFO_0004530, EFO_0008317
Diseaseendometrial carcinoma, endometriosis

TLR10 CEP112

1.63e-03111642EFO_0001065, EFO_1001512
DiseaseBarrett's esophagus (is_implicated_in)

GPX3 MSR1

1.63e-03111642DOID:9206 (is_implicated_in)
DiseaseEmery-Dreifuss muscular dystrophy (implicated_via_orthology)

HOOK3 SYNE2

1.95e-03121642DOID:11726 (implicated_via_orthology)
Diseasemethionine sulfone measurement

CYP3A4 CYP3A43

1.95e-03121642EFO_0800072
Diseaseacute myeloid leukemia (implicated_via_orthology)

TOP2A TOP2B

1.95e-03121642DOID:9119 (implicated_via_orthology)
DiseaseColorectal Carcinoma

ABCB5 CHD1 BRINP1 ACSL4 GMCL2 ARNT ZNHIT6 CCNB3 SLCO2A1 DLG3 JPH3

1.97e-0370216411C0009402
Diseasesevere acute respiratory syndrome (is_marker_for)

SERPINA3 MSR1 FGF7

2.28e-03471643DOID:2945 (is_marker_for)
DiseaseProstatic Neoplasms

SERPINA3 CYP3A4 CYP3A5 CYP3A43 GPX3 CHD1 MSR1 ACSL4 MAPK3 TOP2A

2.43e-0361616410C0033578
DiseaseMalignant neoplasm of prostate

SERPINA3 CYP3A4 CYP3A5 CYP3A43 GPX3 CHD1 MSR1 ACSL4 MAPK3 TOP2A

2.43e-0361616410C0376358
Diseaseurate measurement, bone density

TRPM6 PPFIA2 ABCB5 CCNG1 KIF14 CADPS2 CABIN1 OLIG2 DNAH9 JPH3

2.52e-0361916410EFO_0003923, EFO_0004531
Diseasehepatocellular carcinoma (implicated_via_orthology)

POLG CCNG1 GPC3

2.57e-03491643DOID:684 (implicated_via_orthology)
Diseaseunipolar depression, anxiety

BRINP1 LRRC7

2.67e-03141642EFO_0003761, EFO_0005230
DiseaseHermansky-Pudlak syndrome (implicated_via_orthology)

CCZ1B CCZ1

2.67e-03141642DOID:3753 (implicated_via_orthology)
Diseaseovarian carcinoma (is_implicated_in)

CCNG1 CABIN1

3.07e-03151642DOID:4001 (is_implicated_in)
DiseaseSitus ambiguus

DNAH5 DNAH9

3.07e-03151642C0266642
DiseaseMetastatic melanoma

ROCK2 SIK1 TTBK1

3.40e-03541643C0278883
Diseasethyroid volume

FGF7 DNAH5

3.50e-03161642EFO_0004865
DiseaseFEV/FEC ratio

EFCAB5 VPS13C ITGA8 BRINP1 INPP4B FREM2 SYNE2 KCNN3 MICAL3 MAPK3 DNAH5 ATP2B1 HSPA4 TOP2B JPH3

3.63e-03122816415EFO_0004713
Diseasepneumonia, COVID-19

COPG1 CARD11 UNC80 IQCE

3.70e-031131644EFO_0003106, MONDO_0100096
Diseaseeosinophil count

CUL2 RIN3 KIF27 ABCB5 CCDC18 C16orf96 CHD1 COG6 TRABD SYN2 PCNX1 CARD11 CCR6 OTULINL OLIG2 HSPA4 DCAF4

3.92e-03148816417EFO_0004842
Diseasecancer (implicated_via_orthology)

FRMD6 MACF1 DLG3 MAPK3 TOP2A TOP2B

3.96e-032681646DOID:162 (implicated_via_orthology)
Diseaseneuroblastoma

DOCK2 KRT5 L1TD1 DNAH5

4.07e-031161644EFO_0000621
Diseaseserum non-albumin protein measurement

EFCAB13 SP110 ARNT ELL2 PHLPP1 CARD11 CCR6

4.19e-033611647EFO_0004568
Diseasedrug-Induced dyskinesia, response to levodopa

EXTL3 ADAM10

4.43e-03181642EFO_0010747, EFO_1000904
DiseaseMeckel syndrome type 1

RPGRIP1L KIF14

4.43e-03181642C3714506
Diseaserheumatoid arthritis, ACPA-positive rheumatoid arthritis, rheumatoid factor seropositivity measurement

TYK2 COG6 CCR6

5.24e-03631643EFO_0000685, EFO_0007791, EFO_0009459
Diseasechronic obstructive pulmonary disease

EFCAB5 RIN3 ITGA8 PRDM11 SYN2 MICAL3 DNAH5 HSPA4 DCAF4 TOP2B

5.29e-0368816410EFO_0000341
DiseaseFamilial aplasia of the vermis

RPGRIP1L CPLANE1

5.46e-03201642cv:C0431399

Protein segments in the cluster

PeptideGeneStartEntry
EIMDRIYKNVMSKVQ

ACSL4

376

O60488
RRNKMTAYITELSDM

ARNT

101

P27540
VRILQDEQYLMASDM

DCAF4

376

Q8WV16
NYMIAMRLAQLSEEK

CARD10

206

Q9BWT7
YQMTRERMTQAEEES

ELL2

131

O00472
KEERYLMLFSNVLIM

ARHGEF6

466

Q15052
TDIQIMEYTLANMAK

BRINP1

281

O60477
IKDLDSQTMMVLVNY

SERPINA3

196

P01011
RMRKYQMTGVEEVTQ

ADAM10

181

O14672
VQMEYLDMVVNETLR

CYP3A5

351

P20815
TREKAFEQMYEEMLQ

ABCB5

891

Q2M3G0
NVKMDILSYMRRQAA

GPX3

206

P22352
KARSMTDVYLLNMAI

CCR6

76

P51684
EDTNVRLNKMESEYM

CEP112

386

Q8N8E3
RLNKMESEYMAQTQS

CEP112

391

Q8N8E3
KESRNMNSRVTQLYM

ANGPTL1

121

O95841
QEVVNLKSYMERNML

CCDC144CP

986

Q8IYA2
ESMKTINLLQRMNIY

DPY19L3

121

Q6ZPD9
LDSQVMTALKMERYL

DNHD1

276

Q96M86
RVTDMFTDQEKQLME

CCDC90B

176

Q9GZT6
DNIYINIFDEMMTEK

CC2D2B

966

Q6DHV5
EQILRMEMSALQKQY

CHD1

711

O14646
SQMVRMLDILAEYLK

CHD1

811

O14646
MSLNIITVTLNMEKY

DVL2

261

O14641
TMNRMTVVQAYINEK

ATP2B1

481

P20020
VEEDKSSTMQYVILM

ARHGEF12

536

Q9NZN5
MLKDEVRTLTYRNSM

PRMT1

66

Q99873
LTDYMNRQIEITSDM

CCNB3

1146

Q8WWL7
RNKMTQYITELSDMV

ARNT2

76

Q9HBZ2
KTTNLEEMRIAMETY

IQCE

241

Q6IPM2
QYRFTVSDLMRMEKI

CCNG1

126

P51959
MMFYIDLKQTNDVLL

DCAF1

356

Q9Y4B6
QLSEMLLYMIKEGTT

KIF14

811

Q15058
KLVTVDTTMYEMQAL

OR10A7

186

Q8NGE5
AKILSDMRSQYEVMA

KRT19

246

P08727
VQEKNAMVRYESELM

MICAL3

1901

Q7RTP6
TMTSDILKMQLYVEE

MAD2L2

191

Q9UI95
REMLNLYIENEGKMI

HSPA4

591

P34932
MIQTYVEHIERSKMQ

MAPK8IP3

171

Q9UPT6
YQMEVEAVTRKMENL

RPGRIP1L

526

Q68CZ1
MLVYLDMSKNRIETV

LRRC7

231

Q96NW7
KMEEKYQLTARLNME

GPC3

76

P51654
SRILNEMRDQYEKMA

KRT14

281

P02533
YLSKMISMDIEQVIT

HMGCR

311

P04035
YLALDNKMIVEMLRT

PHKA1

531

P46020
NKMIVEMLRTDLSYL

PHKA1

536

P46020
QMVNMYQDILTELSK

INPP4B

306

O15327
MARLLREYQELMNTK

KRT5

446

P13647
DMLSRIKYLQTRIDM

KCNQ3

556

O43525
INDSEMRAIYMKSLR

FANCM

1556

Q8IYD8
NMIAEMQLTKAIVYI

FREM2

2346

Q5SZK8
MQLTKAIVYIEEMSS

FREM2

2351

Q5SZK8
ARMLREYQELMSVKL

KRT4

416

P19013
LQMEYLDMVVNETLR

CYP3A4

351

P08684
RIDIQMKNRMDGTYA

FLNB

691

O75369
QLYNEEMKMKVLERD

KIF27

1131

Q86VH2
VMDDGTNEYKIIMLN

PCNX1

1916

Q96RV3
LSKMQNVMYDLITEL

KCNN3

631

Q9UGI6
TVEKFQEEMNSYMLI

COG8

386

Q96MW5
TYEELQREMKKSLMD

POLG

451

P54098
SYEMSKEQLMSQEER

GNL1

136

P36915
TLEAMRDVYIVQDLM

MAPK3

111

P27361
MYMQNTVSLEEELRK

HOOK3

346

Q86VS8
ALYQIKEMMQLTRDN

MFSD6

701

Q6ZSS7
MSKDSSYLQERIMVI

MROH9

131

Q5TGP6
IYSLRNQEMKSAMQR

OR4D6

286

Q8NGJ1
MDLELAMLRQQTMVY

ITPRID2

976

P28290
DELRSYSSLMKVENM

CCDC25

181

Q86WR0
LSCEYKMENVTRMVV

ITGA8

711

P53708
EMASRVEQSYQKVMA

MACF1

931

Q9UPN3
RNYILMLTSSLEEMK

OLIG3

131

Q7RTU3
IMLYQVTEVYEQMKT

OTULINL

246

Q9NUU6
EERVYNVSAEIMAMK

MSR1

216

P21757
MLVSIQARSKDISYM

OR7D4

81

Q8NG98
ALELIMSKYREQMFR

FGFR1OP2

96

Q9NVK5
ETTQKARFEMVLDLM

PEX19

241

P40855
MLERFEKYMEDIQSN

CEP135

511

Q66GS9
IMEQMALLQETAYER

COG6

211

Q9Y2V7
IYITEDMLMSRKLNG

FRMD6

481

Q96NE9
MNMSVLTLQEYEFEK

ELOVL6

1

Q9H5J4
MSGYQRLMKEVTEDL

EFCAB5

231

A4FU69
IEQLKMYEMLVTQSH

FHIP1A

116

Q05DH4
MQDEERYMTLNVQSK

KLRF1

1

Q9NZS2
VERIMSETYMLIKQV

CABIN1

1881

Q9Y6J0
KEYERREDFQMQLMT

DOCK2

1366

Q92608
VQMEYLDMVVNETLR

CYP3A43

351

Q9HB55
GNQIEMMKDRYITLD

C16orf96

756

A6NNT2
SESVRQMLQDEMFKL

CPLANE1

2041

Q9H799
MESVMKEQEQYIATQ

CCDC18

1111

Q5T9S5
VIEVINDKDMSYMTV

GALNT5

616

Q7Z7M9
EDRLQEMYLKSKMLS

FNIP2

1056

Q9P278
VMLTYEREEVLMNSL

EXTL3

666

O43909
QMIDFYKDLVTQRVM

AXDND1

301

Q5T1B0
DIRYESMINTMLKDL

ARFGEF3

1551

Q5TH69
MTYLKIQSFINRMEE

CCZ1

201

P86791
VLQELRDISSMAMEY

FBXO28

196

Q9NVF7
RSQTGVQILMKIEYM

ZNHIT6

396

Q9NWK9
KNDMANMYVLLRAVS

CUL2

291

Q13617
MTYLKIQSFINRMEE

CCZ1B

201

P86790
MENMYIEELRSSVNL

CADPS2

301

Q86UW7
DQTLRRMCYLTIKEM

COPG2

81

Q9UBF2
ITDGTMLQAIERYMK

COPG2

131

Q9UBF2
MLQAIERYMKQAIVD

COPG2

136

Q9UBF2
KSIEALMEMNRRQTY

DLG3

746

Q92796
SAITREKEMLSNLYM

EFCAB13

141

Q8IY85
SYLTQMDVKLVFVME

GEN1

61

Q17RS7
ITDSTMLQAIERYMK

COPG1

131

Q9Y678
MLQAIERYMKQAIVD

COPG1

136

Q9Y678
IQMFNKDLDAVRMIY

DNAH9

571

Q9NYC9
REIYEISMQLMQILE

FRY

1271

Q5TBA9
QEVVNLKSYMERNML

CCDC144A

1176

A2RUR9
MKNNYNIMEIRTVAV

FGF7

91

P21781
STIQMLFYMEKREAL

IFT140

231

Q96RY7
YKHRMNTVMLQLEEV

CARD11

361

Q9BXL7
RQYQIDAAIVRIMKM

CUL4B

846

Q13620
LMTDLEKNALIMYSR

HELB

286

Q8NG08
LMFQRTIESYVDKRM

DNAH5

2626

Q8TE73
TEMRLVNEMYQTSLR

DNAH5

3831

Q8TE73
EEMNTKYQRDIREAM

PPFIA2

316

O75334
LQEIRTMMTQLKSYL

RIN3

641

Q8TB24
MLTVRRMELKADQLY

PDHA2

66

P29803
MDQVSLLISVMDYDR

SYT6

441

Q5T7P8
SAMLEQIAMSDRYKL

SYN1

341

P17600
SAMLEQIAMSDRYKL

SYN2

341

Q92777
KEQTVQYILTMVDDM

ATP6V1H

86

Q9UI12
TLRYGKIMIMTDQDQ

TOP2B

551

Q02880
MERQSRVMSEKDEYQ

SLC9A9

1

Q8IVB4
KNFIQLETYSEVMMV

TLR10

531

Q9BXR5
MEEVMRTYLKQQEKL

SKIL

531

P12757
MDNRNTQMYTEEEKT

SPATA21

1

Q7Z572
EESQKELESYMMRAQ

SYNE2

851

Q8WXH0
DNMVQRLETDFKMTL

RFX3

546

P48380
ELKIMNTEQYIQTMT

NT5DC3

416

Q86UY8
LFVMQVEMDVYTTLK

GMCL2

266

Q8NEA9
EDYMKRLHSMSQETI

PRDM11

261

Q9NQV5
MLREKMEYSAQLQAA

PTPN14

726

Q15678
VTYMEASAKIRMNVD

RRAS2

151

P62070
QVMETKDMLYIVTEF

SIK1B

91

A0A0B4J2F2
QVMETKDMLYIVTEF

SIK1

91

P57059
NYEKASDNIIMRLMA

SHOC1

931

Q5VXU9
NTIYIDEVLCMQMRK

TEKT1

381

Q969V4
RNYILMLTNSLEEMK

OLIG2

156

Q13516
MLVNIQTENKAISYM

OR7D2

81

Q96RA2
YQKVLDTLRDAMMSQ

POMK

331

Q9H5K3
GLLDNSIITKRMYME

SP110

36

Q9HB58
DIISTMFNRKFMEEL

OSCP1

51

Q8WVF1
ILTQAYKRMAEEAMQ

STK36

301

Q9NRP7
RLSIMKEILSDQYQM

SPICE1

91

Q8N0Z3
EKLARMVMLQYVTES

ACADVL

381

P49748
IMDRIYKNVMNKVSE

ACSL3

386

O95573
LYMMVLRVVNQEEKS

SLCO2A1

536

Q92959
MRVSTEEELKFLQMA

RNF213

3776

Q63HN8
RVEQMTKTYNDIDMV

TRAK2

101

O60296
YQLIMSVFENSMKER

TTBK1

286

Q5TCY1
KLTISNRQDELMYML

UNC80

1896

Q8N2C7
TSERVTEMYFQLKEM

TRPM6

1176

Q9BX84
LLNSYIENEGKMIMQ

HSPA4L

596

O95757
SEITRLQMELMEYKT

KIF21A

391

Q7Z4S6
ELCQYRVSMLKMDES

TRABD

106

Q9H4I3
RTSEAMYNKMNISEL

PHEX

291

P78562
MEIDMTYQLKVIQQS

ROCK2

686

O75116
MIDLLESVDYMVRNA

VPS13C

341

Q709C8
VALMETKNREGLNYM

ROS1

2261

P08922
KTLLVYDMNLREMEN

THOC7

66

Q6I9Y2
LEELSQRYRKQMEEM

SUCO

936

Q9UBS9
IAAILDMYTLMSNKQ

TMOD4

131

Q9NZQ9
GALRETMYRTQKEMQ

SLF1

236

Q9BQI6
LRYGKIMIMTDQDQD

TOP2A

531

P11388
EETLSQKRFLMNTEM

ZNF507

406

Q8TCN5
VERLQALYMIRMKDS

USP41

161

Q3LFD5
TKNEEEYMVNTFIVM

PHLPP1

1236

O60346
LKVITIYNQEMESME

SEMA3E

461

O15041
KMVNYIQMKLDLERE

TWF2

196

Q6IBS0
REKMVYMTVNDSQQE

ZFY

291

P08048
SQQMVMVKYLATLER

TYK2

251

P29597
MSQLVEEMLLKQRDF

KEL

346

P23276
LELQEEKLSNYRMEM

JPH3

601

Q8WXH2
IQDLMFEEMRETLKN

L1TD1

61

Q5T7N2