Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	WW domain binding	NFE2 TP63 DAZAP2	4.12e-05	25	54	3	GO:0050699
GeneOntologyMolecularFunction	SMAD binding	TGFB1I1 ZMIZ1 USP9Y SMAD9	8.61e-05	86	54	4	GO:0046332
GeneOntologyMolecularFunction	MDM2/MDM4 family protein binding	TP63 TP73	5.49e-04	13	54	2	GO:0097371
GeneOntologyMolecularFunction	transcription factor binding	TGFB1I1 TBX18 NCOR1 EGR2 NAB2 DAZAP2 TP73 CRTC2	8.83e-04	753	54	8	GO:0008134
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	TGFB1I1 TBX18 NCOR1 EGR2 DAZAP2 TP73 CRTC2	9.31e-04	582	54	7	GO:0140297
GeneOntologyMolecularFunction	I-SMAD binding	TGFB1I1 SMAD9	9.51e-04	17	54	2	GO:0070411
GeneOntologyMolecularFunction	p53 binding	TP63 DAZAP2 TP73	1.19e-03	77	54	3	GO:0002039
GeneOntologyMolecularFunction	SUMO ligase activity	EGR2 ZMIZ1	1.32e-03	20	54	2	GO:0061665
GeneOntologyMolecularFunction	mitogen-activated protein kinase kinase kinase binding	TRIM8 DAZAP2	2.24e-03	26	54	2	GO:0031435
GeneOntologyMolecularFunction	protein domain specific binding	SHISA9 NCOR1 EFS EGR2 ABI2 NFE2 TP63 DAZAP2	2.29e-03	875	54	8	GO:0019904
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	EGR2 CBLL2 HECTD4 TRIM8 PEX12 ZMIZ1	2.51e-03	512	54	6	GO:0019787
GeneOntologyMolecularFunction	aminoacyltransferase activity	EGR2 CBLL2 HECTD4 TRIM8 PEX12 ZMIZ1	3.04e-03	532	54	6	GO:0016755
GeneOntologyMolecularFunction	transcription coregulator activity	TGFB1I1 NCOR1 KMT2C NAB2 TRIM8 ZMIZ1	3.98e-03	562	54	6	GO:0003712
GeneOntologyMolecularFunction	SUMO transferase activity	EGR2 ZMIZ1	4.26e-03	36	54	2	GO:0019789
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	EGR2 CBLL2 TRIM8 PEX12 ZMIZ1	4.35e-03	398	54	5	GO:0061659
GeneOntologyMolecularFunction	acyltransferase activity	KMT2C EGR2 CBLL2 HECTD4 TRIM8 PEX12 ZMIZ1	4.68e-03	775	54	7	GO:0016746
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	TBX18 NCOR1 HOXD3 EGR2 NFE2 TP63 IRF7 BATF2 TP73 SMAD9	5.22e-03	1459	54	10	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	TGFB1I1 TBX18 NCOR1 EGR2 TP73	5.30e-03	417	54	5	GO:0061629
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	TBX18 HOXD3 EGR2 NFE2 TP63 IRF7 BATF2 TP73 SMAD9	5.76e-03	1244	54	9	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	TBX18 HOXD3 EGR2 NFE2 TP63 IRF7 BATF2 TP73 SMAD9	6.61e-03	1271	54	9	GO:0000987
GeneOntologyCellularComponent	chromatin	TBX18 NCOR1 HOXD3 EGR2 NFE2 BICRA TP63 IRF7 ZMIZ1 BATF2 TP73 SMAD9	2.66e-04	1480	53	12	GO:0000785
HumanPheno	No social interaction	IQSEC2 TRIM8 SH2B1	1.39e-06	6	22	3	HP:0008763
HumanPheno	Velopharyngeal insufficiency	DGCR2 BICRA TP63 IQSEC2	1.57e-05	37	22	4	HP:0000220
HumanPheno	Abnormal relationship	IQSEC2 TRIM8 SH2B1	3.78e-05	16	22	3	HP:5200024
HumanPheno	Moderate receptive language delay	KMT2C SH2B1	5.33e-05	3	22	2	HP:0011351
Domain	P53	TP63 TP73	2.19e-05	3	51	2	PF00870
Domain	P53	TP63 TP73	2.19e-05	3	51	2	PS00348
Domain	-	TP63 TP73	2.19e-05	3	51	2	4.10.170.10
Domain	p53_DNA-bd	TP63 TP73	2.19e-05	3	51	2	IPR011615
Domain	p53_tetrameristn	TP63 TP73	2.19e-05	3	51	2	IPR010991
Domain	P53_tetramer	TP63 TP73	2.19e-05	3	51	2	PF07710
Domain	p53_tumour_suppressor	TP63 TP73	2.19e-05	3	51	2	IPR002117
Domain	p53/RUNT-type_TF_DNA-bd	TP63 TP73	1.09e-04	6	51	2	IPR012346
Domain	-	TP63 TP73	1.09e-04	6	51	2	2.60.40.720
Domain	p53-like_TF_DNA-bd	TBX18 TP63 TP73	4.08e-04	53	51	3	IPR008967
Domain	LY	LRP5 ROS1	7.50e-04	15	51	2	SM00135
Domain	LDLR_classB_rpt	LRP5 ROS1	7.50e-04	15	51	2	IPR000033
Domain	SMAD_dom-like	IRF7 SMAD9	8.56e-04	16	51	2	IPR017855
Domain	-	IRF7 SMAD9	8.56e-04	16	51	2	2.60.200.10
Domain	SH3_9	EFS ABI2 ARHGEF5	1.26e-03	78	51	3	PF14604
Domain	-	KMT2C CBLL2 TRIM8 PEX12 ZMIZ1 PYGO1	1.35e-03	449	51	6	3.30.40.10
Domain	Znf_RING/FYVE/PHD	KMT2C CBLL2 TRIM8 PEX12 ZMIZ1 PYGO1	1.51e-03	459	51	6	IPR013083
Domain	-	TP63 NAB2 TP73	3.04e-03	106	51	3	1.10.150.50
Domain	GPS	ADGRG2 ADGRD2	3.88e-03	34	51	2	SM00303
Domain	bZIP_1	NFE2 BATF2	3.88e-03	34	51	2	PF00170
Domain	SAM/pointed	TP63 NAB2 TP73	4.01e-03	117	51	3	IPR013761
Domain	GPS	ADGRG2 ADGRD2	4.11e-03	35	51	2	PF01825
Domain	GPS	ADGRG2 ADGRD2	4.34e-03	36	51	2	PS50221
Domain	GPS	ADGRG2 ADGRD2	4.58e-03	37	51	2	IPR000203
Domain	-	LRP5 ROS1	5.08e-03	39	51	2	2.120.10.30
Domain	LDLR_class-A_CS	DGCR2 LRP5	5.34e-03	40	51	2	IPR023415
Domain	SAM_2	TP63 TP73	6.15e-03	43	51	2	PF07647
Domain	Ldl_recept_a	DGCR2 LRP5	6.71e-03	45	51	2	PF00057
Domain	-	DGCR2 LRP5	7.01e-03	46	51	2	4.10.400.10
Domain	6-blade_b-propeller_TolB-like	LRP5 ROS1	7.01e-03	46	51	2	IPR011042
Domain	LDLRA_1	DGCR2 LRP5	7.61e-03	48	51	2	PS01209
Domain	LDLRA_2	DGCR2 LRP5	7.92e-03	49	51	2	PS50068
Domain	LDrepeatLR_classA_rpt	DGCR2 LRP5	7.92e-03	49	51	2	IPR002172
Domain	LDLa	DGCR2 LRP5	7.92e-03	49	51	2	SM00192
Domain	G_PROTEIN_RECEP_F2_2	ADGRG2 ADGRD2	8.24e-03	50	51	2	PS00650
Domain	7tm_2	ADGRG2 ADGRD2	8.24e-03	50	51	2	PF00002
Domain	ZF_RING_2	KMT2C CBLL2 TRIM8 PEX12	8.81e-03	298	51	4	PS50089
Pathway	REACTOME_NGF_STIMULATED_TRANSCRIPTION	EGR2 NAB2	9.99e-05	6	37	2	MM15627
Pathway	REACTOME_ACTIVATION_OF_PUMA_AND_TRANSLOCATION_TO_MITOCHONDRIA	TP63 TP73	2.39e-04	9	37	2	M26946
Pathway	REACTOME_ACTIVATION_OF_ANTERIOR_HOX_GENES_IN_HINDBRAIN_DEVELOPMENT_DURING_EARLY_EMBRYOGENESIS	NCOR1 KMT2C HOXD3 EGR2	2.83e-04	122	37	4	M29689
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_DEATH_RECEPTORS_AND_LIGANDS	TP63 TP73	4.35e-04	12	37	2	M27631
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CASPASE_ACTIVATORS_AND_CASPASES	TP63 TP73	4.35e-04	12	37	2	M27630
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_SEVERAL_ADDITIONAL_CELL_DEATH_GENES_WHOSE_SPECIFIC_ROLES_IN_P53_DEPENDENT_APOPTOSIS_REMAIN_UNCERTAIN	TP63 TP73	5.98e-04	14	37	2	M27629
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ASSOCIATION_WITH_CO_FACTORS	TP63 TP73	5.98e-04	14	37	2	M27638
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ASSOCIATION_WITH_CO_FACTORS	TP63 TP73	5.98e-04	14	37	2	MM15341
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	TGFB1I1 NCOR1 EGR2 BICRA ARHGEF5 TP63 SH2B1 TP73 CRTC2	2.02e-08	430	54	9	35044719
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	TGFB1I1 TBX18 DENND4A HOXD3 NFE2 TP63 NAB2 DAZAP2 IRF7 TP73 PYGO1	8.77e-08	877	54	11	20211142
Pubmed	p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer's disease.	RBFOX3 TP63 TP73	1.27e-06	14	54	3	18786355
Pubmed	p63 and p73 expression in extrahepatic bile duct carcinoma and their clinical significance.	TP63 TP73	2.37e-06	2	54	2	17385050
Pubmed	p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis.	TP63 TP73	2.37e-06	2	54	2	16413471
Pubmed	The role of p53 protein family in gastrointestinal malignancies.	TP63 TP73	2.37e-06	2	54	2	16557273
Pubmed	Tumor-specific p73 up-regulation mediates p63 dependence in squamous cell carcinoma.	TP63 TP73	2.37e-06	2	54	2	17018588
Pubmed	The 5th International p63/p73 Workshop: much more than just tumour suppression.	TP63 TP73	2.37e-06	2	54	2	22240899
Pubmed	Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization.	TP63 TP73	2.37e-06	2	54	2	27716744
Pubmed	Conformational stability and activity of p73 require a second helix in the tetramerization domain.	TP63 TP73	2.37e-06	2	54	2	19763140
Pubmed	Polymorphisms in the p63 and p73 genes are associated with ovarian cancer risk and clinicopathological variables.	TP63 TP73	2.37e-06	2	54	2	23095717
Pubmed	p73 and p63 regulate the expression of fibroblast growth factor receptor 3.	TP63 TP73	2.37e-06	2	54	2	20298673
Pubmed	P634A4 and TAp73 immunocytochemistry in liquid-based cervical cytology--potential biomarkers for diagnosis and progress prediction of cervical neoplasia.	TP63 TP73	2.37e-06	2	54	2	20081800
Pubmed	Distinct p63 and p73 Protein Interactions Predict Specific Functions in mRNA Splicing and Polyploidy Control in Epithelia.	TP63 TP73	2.37e-06	2	54	2	33375680
Pubmed	p63 and p73: roles in development and tumor formation.	TP63 TP73	2.37e-06	2	54	2	15280445
Pubmed	p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53.	TP63 TP73	2.37e-06	2	54	2	10373484
Pubmed	p63 and p73 do not contribute to p53-mediated lymphoma suppressor activity in vivo.	TP63 TP73	2.37e-06	2	54	2	16007185
Pubmed	TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.	TP63 TP73	2.37e-06	2	54	2	24983500
Pubmed	The Role of p63 and p73 in tumor formation and progression: coming of age toward clinical usefulness. Commentary re: F. Koga et al., Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladder. Clin. Cancer Res., 9: 5501-5507, 2003, and P. Puig et al., p73 Expression in human normal and tumor tissues: loss of p73alpha expression is associated with tumor progression in bladder Cancer. Clin. Cancer Res., 9: 5642-5651, 2003.	TP63 TP73	2.37e-06	2	54	2	14654522
Pubmed	Role of p63 and p73 isoforms on the cell death in patients with hepatocellular carcinoma submitted to orthotopic liver transplantation.	TP63 TP73	2.37e-06	2	54	2	28350813
Pubmed	Genome-wide mapping indicates that p73 and p63 co-occupy target sites and have similar dna-binding profiles in vivo.	TP63 TP73	2.37e-06	2	54	2	20644729
Pubmed	The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers.	TP63 TP73	2.37e-06	2	54	2	17446929
Pubmed	Tissue-specific expression of p73 and p63 isoforms in human tissues.	TP63 TP73	2.37e-06	2	54	2	34315849
Pubmed	p63 antagonizes p53 to promote the survival of embryonic neural precursor cells.	TP63 TP73	2.37e-06	2	54	2	19458240
Pubmed	While p73 is essential, p63 is completely dispensable for the development of the central nervous system.	TP63 TP73	2.37e-06	2	54	2	21293190
Pubmed	BMP4 uses several different effector pathways to regulate proliferation and differentiation in the epithelial and mesenchymal tissue compartments of the developing mouse ureter.	TBX18 TP63 SMAD9	3.96e-06	20	54	3	28655168
Pubmed	Neuronal survival and p73/p63/p53: a family affair.	TP63 TP73	7.09e-06	3	54	2	15359011
Pubmed	The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cells.	TP63 TP73	7.09e-06	3	54	2	16181796
Pubmed	Glyoxalase II, a detoxifying enzyme of glycolysis byproduct methylglyoxal and a target of p63 and p73, is a pro-survival factor of the p53 family.	TP63 TP73	7.09e-06	3	54	2	16831876
Pubmed	Evaluating the Influence of a G-Quadruplex Prone Sequence on the Transactivation Potential by Wild-Type and/or Mutant P53 Family Proteins through a Yeast-Based Functional Assay.	TP63 TP73	7.09e-06	3	54	2	33672023
Pubmed	p53 Family isoforms.	TP63 TP73	7.09e-06	3	54	2	18289041
Pubmed	The integrin alpha(v)beta(3-5) ligand MFG-E8 is a p63/p73 target gene in triple-negative breast cancers but exhibits suppressive functions in ER(+) and erbB2(+) breast cancers.	TP63 TP73	7.09e-06	3	54	2	21127199
Pubmed	Differential regulation of vitamin D receptor (VDR) by the p53 Family: p73-dependent induction of VDR upon DNA damage.	TP63 TP73	7.09e-06	3	54	2	17716971
Pubmed	Regulation and function of the p53-related proteins: same family, different rules.	TP63 TP73	7.09e-06	3	54	2	10754563
Pubmed	p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress.	TP63 TP73	7.09e-06	3	54	2	16601753
Pubmed	Differential expression of p53 gene family members p63 and p73 in head and neck squamous tumorigenesis.	TP63 TP73	7.09e-06	3	54	2	11957139
Pubmed	iASPP inhibits p53-independent apoptosis by inhibiting transcriptional activity of p63/p73 on promoters of proapoptotic genes.	TP63 TP73	7.09e-06	3	54	2	22538442
Pubmed	The emerging p53 gene family.	TP63 TP73	7.09e-06	3	54	2	10203277
Pubmed	The tumor suppressors p53, p63, and p73 are regulators of microRNA processing complex.	TP63 TP73	7.09e-06	3	54	2	20485546
Pubmed	Nab proteins are essential for peripheral nervous system myelination.	EGR2 NAB2	7.09e-06	3	54	2	16136673
Pubmed	Melanocyte and keratinocyte carcinogenesis: p53 family protein activities and intersecting mRNA expression profiles.	TP63 TP73	7.09e-06	3	54	2	16363065
Pubmed	p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells.	TP63 TP73	7.09e-06	3	54	2	24809925
Pubmed	Crystal structures of the DNA-binding domain tetramer of the p53 tumor suppressor family member p73 bound to different full-site response elements.	TP63 TP73	7.09e-06	3	54	2	23243311
Pubmed	p53, p63 and p73--solos, alliances and feuds among family members.	TP63 TP73	7.09e-06	3	54	2	11825686
Pubmed	The dominant-negative interplay between p53, p63 and p73: A family affair.	TP63 TP73	7.09e-06	3	54	2	27589690
Pubmed	ΔNp63 regulates select routes of reprogramming via multiple mechanisms.	TP63 TP73	7.09e-06	3	54	2	24013722
Pubmed	Interaction between TP63 and MDM2 genes and the risk of recurrent pregnancy loss.	TP63 TP73	7.09e-06	3	54	2	25218545
Pubmed	The p53 family: guardians of maternal reproduction.	TP63 TP73	7.09e-06	3	54	2	21427767
Pubmed	Physical interaction with Yes-associated protein enhances p73 transcriptional activity.	TP63 TP73	7.09e-06	3	54	2	11278685
Pubmed	[Clinical significance of the expression of p53, p63 and p73 in nasal and paranasal sinus carcinoma].	TP63 TP73	7.09e-06	3	54	2	19119599
Pubmed	p63 and p73 are not required for the development and p53-dependent apoptosis of T cells.	TP63 TP73	7.09e-06	3	54	2	15261144
Pubmed	Expression of p53 family in scars.	TP63 TP73	7.09e-06	3	54	2	14757278
Pubmed	Diverse p63 and p73 isoforms regulate Δ133p53 expression through modulation of the internal TP53 promoter activity.	TP63 TP73	7.09e-06	3	54	2	22075982
Pubmed	Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family.	TP63 TP73	7.09e-06	3	54	2	15837625
Pubmed	Structural evolution of p53, p63, and p73: implication for heterotetramer formation.	TP63 TP73	7.09e-06	3	54	2	19815500
Pubmed	S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation.	TP63 TP73	7.09e-06	3	54	2	16449968
Pubmed	deltaEF1 repressor controls selectively p53 family members during differentiation.	TP63 TP73	7.09e-06	3	54	2	16007124
Pubmed	The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators.	EGR2 NAB2	7.09e-06	3	54	2	21836637
Pubmed	Expression of p53 family genes in urinary bladder cancer: correlation with disease aggressiveness and recurrence.	TP63 TP73	7.09e-06	3	54	2	24213852
Pubmed	Intrinsic aggregation propensity of the p63 and p73 TI domains correlates with p53R175H interaction and suggests further significance of aggregation events in the p53 family.	TP63 TP73	7.09e-06	3	54	2	27447112
Pubmed	p63 and p73 are required for p53-dependent apoptosis in response to DNA damage.	TP63 TP73	7.09e-06	3	54	2	11932750
Pubmed	Tumor suppressors p53, p63TAα, p63TAy, p73α, and p73β use distinct pathways to repress telomerase expression.	TP63 TP73	7.09e-06	3	54	2	22496369
Pubmed	Regulation of the Activity in the p53 Family Depends on the Organization of the Transactivation Domain.	TP63 TP73	7.09e-06	3	54	2	30099987
Pubmed	Nab proteins mediate a negative feedback loop controlling Krox-20 activity in the developing hindbrain.	EGR2 NAB2	7.09e-06	3	54	2	10654606
Pubmed	How the TP53 family proteins TP63 and TP73 contribute to tumorigenesis: regulators and effectors.	TP63 TP73	7.09e-06	3	54	2	24488880
Pubmed	A novel response element confers p63- and p73-specific activation of the WNT4 promoter.	TP63 TP73	7.09e-06	3	54	2	16343436
Pubmed	Novel therapeutic interventions for p53-altered tumors through manipulation of its family members, p63 and p73.	TP63 TP73	7.09e-06	3	54	2	26652033
Pubmed	Adhesion G protein-coupled receptor G2 is dispensable for lumicrine signaling regulating epididymal initial segment differentiation and gene expression†.	ADGRG2 ROS1	7.09e-06	3	54	2	37531264
Pubmed	Differential expression of p53, p63 and p73 proteins in human buccal squamous-cell carcinomas.	TP63 TP73	7.09e-06	3	54	2	12969350
Pubmed	A census of human transcription factors: function, expression and evolution.	TBX18 HOXD3 EGR2 NFE2 TP63 IRF7 BATF2 TP73 SMAD9	1.00e-05	908	54	9	19274049
Pubmed	p63 and p73 repress CXCR5 chemokine receptor gene expression in p53-deficient MCF-7 breast cancer cells during genotoxic stress.	TP63 TP73	1.42e-05	4	54	2	29107083
Pubmed	A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain.	TP63 TP73	1.42e-05	4	54	2	11238924
Pubmed	Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.	TP63 TP73	1.42e-05	4	54	2	15607981
Pubmed	Mutant p53 antagonizes p63/p73-mediated tumor suppression via Notch1.	TP63 TP73	1.42e-05	4	54	2	31712410
Pubmed	Gene expression of cyclin-dependent kinase subunit Cks2 is repressed by the tumor suppressor p53 but not by the related proteins p63 or p73.	TP63 TP73	1.42e-05	4	54	2	17336302
Pubmed	Identification of Daxx interacting with p73, one of the p53 family, and its regulation of p53 activity by competitive interaction with PML.	TP63 TP73	1.42e-05	4	54	2	12954772
Pubmed	p73 Interacts with c-Myc to regulate Y-box-binding protein-1 expression.	DENND4A TP73	1.42e-05	4	54	2	12080043
Pubmed	NCoR1 fine-tunes type-I IFN response in cDC1 dendritic cells by directly regulating Myd88-IRF7 axis under TLR9.	NCOR1 IRF7	1.42e-05	4	54	2	32644192
Pubmed	E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis.	TP63 TP73	1.42e-05	4	54	2	25146927
Pubmed	EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin.	EGR2 NAB2	1.42e-05	4	54	2	20506119
Pubmed	Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies.	TP63 TP73	1.42e-05	4	54	2	29988075
Pubmed	p73 and p63 protein stability: the way to regulate function?	TP63 TP73	1.42e-05	4	54	2	14555234
Pubmed	ASPP1 and ASPP2: common activators of p53 family members.	TP63 TP73	1.42e-05	4	54	2	14729977
Pubmed	Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo.	TP63 TP73	1.42e-05	4	54	2	11925430
Pubmed	Functional interplay between MDM2, p63/p73 and mutant p53.	TP63 TP73	1.42e-05	4	54	2	25417702
Pubmed	The joint effect of cigarette smoking and polymorphisms on LRP5, LEPR, near MC4R and SH2B1 genes on metabolic syndrome susceptibility in Taiwan.	LRP5 SH2B1	1.42e-05	4	54	2	23054017
Pubmed	TNF-α promotes c-REL/ΔNp63α interaction and TAp73 dissociation from key genes that mediate growth arrest and apoptosis in head and neck cancer.	TP63 TP73	1.42e-05	4	54	2	21933882
Pubmed	IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo.	TP63 TP73	1.42e-05	4	54	2	25409149
Pubmed	Thymine-DNA glycosylase interacts with and functions as a coactivator of p53 family proteins.	TP63 TP73	1.42e-05	4	54	2	18951877
Pubmed	The transcriptional repressor hDaxx potentiates p53-dependent apoptosis.	TP63 TP73	1.42e-05	4	54	2	15339933
Pubmed	Physical interaction between Wilms tumor 1 and p73 proteins modulates their functions.	TP63 TP73	1.42e-05	4	54	2	10744705
Pubmed	The p53 family members have distinct roles during mammalian embryonic development.	TP63 TP73	1.42e-05	4	54	2	28211873
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CASC3 NCOR1 ABI2 NHSL2 NISCH IQSEC2 HECTD4 DCHS1 PRRT1	1.60e-05	963	54	9	28671696
Pubmed	Interaction network of human early embryonic transcription factors.	NCOR1 KMT2C EGR2 BICRA NAB2 ZMIZ1	1.74e-05	351	54	6	38297188
Pubmed	An extended regulatory landscape drives Tbx18 activity in a variety of prostate-associated cell lineages.	TBX18 RBFOX3	2.36e-05	5	54	2	30594504
Pubmed	Interaction of regulators Mdm2 and Mdmx with transcription factors p53, p63 and p73.	TP63 TP73	2.36e-05	5	54	2	21088494
Pubmed	The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells.	TP63 TP73	2.36e-05	5	54	2	27889317
Pubmed	Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3.	EGR2 NAB2	2.36e-05	5	54	2	18203138
Pubmed	Molecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2.	TP63 TP73	2.36e-05	5	54	2	23251530
Pubmed	An anterograde pathway for sensory axon degeneration gated by a cytoplasmic action of the transcriptional regulator P53.	TP63 TP73	2.36e-05	5	54	2	33823136
Interaction	PPP2R2C interactions	CBLL2 TP63 REPIN1 SMAD9	2.89e-05	67	53	4	int:PPP2R2C
Interaction	TCF7 interactions	RBFOX3 DAZAP2 ZMIZ1	2.93e-05	23	53	3	int:TCF7
Interaction	NPIPB13 interactions	TP63 TP73	4.06e-05	4	53	2	int:NPIPB13
Interaction	KAT2B interactions	EGR2 NFE2 TP63 IRF7 TP73 SMAD9	5.52e-05	256	53	6	int:KAT2B
Cytoband	7q36.1	KMT2C REPIN1 ZNF783	9.40e-05	74	54	3	7q36.1
Cytoband	Ensembl 112 genes in cytogenetic band chr7q36	KMT2C REPIN1 ZNF783	8.88e-04	159	54	3	chr7q36
Coexpression	WANG_CLIM2_TARGETS_UP	ABI2 TP63 NISCH TRIM8 REPS2 ZNF783 TP73	1.33e-06	270	54	7	M10334
Coexpression	IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR	SIAE ABI2 ARHGEF5 ZMIZ1 REPIN1 SH2B1 C8orf58 SMAD9	2.16e-05	574	54	8	M8215
Coexpression	IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR	SIAE ABI2 ARHGEF5 ZMIZ1 REPIN1 SH2B1 C8orf58 SMAD9	2.96e-05	600	54	8	MM1025
Coexpression	GSE27786_BCELL_VS_CD4_TCELL_DN	NCOR1 ABI2 NHSL2 NAB2 PRRT1	5.48e-05	198	54	5	M4800
Coexpression	GSE360_T_GONDII_VS_B_MALAYI_LOW_DOSE_MAC_DN	IQSEC2 DCHS1 IRF7 ZMIZ1 SH2B1	5.61e-05	199	54	5	M5257
Coexpression	GSE27786_LIN_NEG_VS_MONO_MAC_DN	NCOR1 BICRA DAZAP2 SLC35G6 SH2B1	5.74e-05	200	54	5	M4798
Coexpression	GSE46606_IRF4_KO_VS_WT_UNSTIM_BCELL_DN	TP63 PTPN23 PROB1 IRF7 PRRT1	5.74e-05	200	54	5	M9861
Coexpression	GSE3982_EOSINOPHIL_VS_EFF_MEMORY_CD4_TCELL_UP	MMP25 DENND4A NFE2 ZMIZ1 REPS2	5.74e-05	200	54	5	M5416
Coexpression	YAP1_UP	SIAE BICRA C8orf58	1.26e-04	47	54	3	M2845
Drug	Riboflavine [83-88-5]; Down 200; 10.6uM; MCF7; HT_HG-U133A	TGFB1I1 DENND4A ADGRG2 NAB2 RPRD2 SH2B1	6.02e-06	199	52	6	6822_DN
Disease	testosterone measurement	CASC3 DENND4A EGR2 NHSL2 NISCH IQSEC2 PALM3 LRP5 ZMIZ1 PRRT1 SH2B1	1.11e-05	1275	52	11	EFO_0004908
Disease	testicular cancer (implicated_via_orthology)	TP63 TP73	3.04e-05	5	52	2	DOID:2998 (implicated_via_orthology)
Disease	reticulocyte count	DENND4A NFE2 NISCH HECTD4 PALM3 PEX12 LRP5 ADGRD2	4.54e-04	1045	52	8	EFO_0007986
Disease	otitis media (implicated_via_orthology)	NISCH TP73	6.88e-04	22	52	2	DOID:10754 (implicated_via_orthology)
Disease	response to perphenazine	SHISA9 C4orf54	9.64e-04	26	52	2	GO_0097334
Disease	gamma-glutamyltyrosine measurement	SHISA9 ZMIZ1	1.04e-03	27	52	2	EFO_0021144
Disease	Colorectal Carcinoma	KMT2C EFS TP63 DCHS1 ZMIZ1 SMAD9	1.43e-03	702	52	6	C0009402

Protein segments in the cluster

Peptide	Gene	Start	Entry
DSAPPSPAEAYPITP	ARHGEF5	516	Q12774
EPPDYSPVTHNVPSP	ADGRG2	281	Q8IZP9
NPPRLPETPVEPTYH	C8orf58	271	Q8NAV2
IPQKQHYAPPPSPSS	CBLL2	276	Q8N7E2
PFYSQNPVSDTPPPP	ABI2	391	Q9NYB9
HLPSPDPVTVPYLSP	DENND4A	1626	Q7Z401
PPHPTQDYSGQTPVP	RBFOX3	26	A6NFN3
QTQPDLDHLYSPPPP	EGR2	156	P11161
PPPLHTQLYPGPAQD	PTPN23	1011	Q9H3S7
AHPVPTYAPARQPEP	PALM3	636	A6NDB9
YLPPPHPAQAQLQSP	MMP25	41	Q9NPA2
REPPSPPPSEHLYHQ	DCHS1	2991	Q96JQ0
TLHLPQAPPYTDAPP	DAZAP2	26	Q15038
NDPYSQPPLTPHPAV	KMT2C	2091	Q8NEZ4
SHPEIQQPPPGPESY	NAB2	386	Q15742
LHQPTSPLPLYSPAP	IQSEC2	1361	Q5JU85
LNSDSDPYPPPPTPH	LRP5	1566	O75197
DPYPPPPTPHSQYLS	LRP5	1571	O75197
PESPHQAEPYLSPSP	IRF7	261	Q92985
PHQPYPPPAAASSLD	HOXD3	46	P31249
YENFITSGPDPHPPP	HECTD4	2216	Q9Y4D8
PAPVIPSNTDYPGPH	TP73	111	O15350
PSPAIPSNTDYPGPH	TP63	161	Q9H3D4
PIYTHGDSPAPLPPQ	CASC3	556	O15234
PLPTPLDPEETAYPS	CRTC2	286	Q53ET0
YPAQPLSPGPQPHDS	BATF2	131	Q8N1L9
PAQPGSPYPAPDHSN	EFS	81	O43281
DPPPPYEASIHPDSV	DGCR2	446	P98153
PSVESQPYSDPHIPP	ELP5	231	Q8TE02
QPYSDPHIPPVDPTT	ELP5	236	Q8TE02
PPLHRPEAYPPSSHN	BICRA	1536	Q9NZM4
SPEHPPTTIYHQPPL	C4orf54	1551	D6RIA3
SGLPDSVPHTSPPPY	PRRT1	6	Q99946
SVPHTSPPPYNAPQP	PRRT1	11	Q99946
SLPQKQYPDSPHPVP	RPRD2	956	Q5VT52
PPYELPASTSHVPDP	NFE2	81	Q16621
PLSEYAPPPNPNSDH	PYGO1	51	Q9Y3Y4
TVHPLSAPYPPLDTP	SH2B1	486	Q9NRF2
PPSLVHKPPSVPEEY	NHSL2	881	Q5HYW2
PYEPISPPQVPVVHE	NCOR1	2146	O75376
QCPLYHPSSALPAPP	SIAE	491	Q9HAT2
SSDPLGTRPQHYPPP	SHISA9	396	B4DS77
LTALPTPPPPVHLDY	PEX12	276	O00623
TPPPPVHLDYNSDSP	PEX12	281	O00623
QEPPALGPPAPAHYT	PROB1	666	E7EW31
PEHPQDPIEAPPSLY	REPIN1	361	Q9BWE0
PESPYQHSVDTPPLP	SMAD9	216	O15198
AQSPLFPPHPPSPYT	ADGRD2	596	Q7Z7M1
PPSSPPHYQRVPLSH	REPS2	196	Q8NFH8
SPVPPRVYIHPDSPA	TBX18	216	O95935
APPPAEAPAQYPSEH	NISCH	1096	Q9Y2I1
PPSPSYRTHPHGVPE	ROS1	181	P08922
PSPSEDAPLYPHSPA	USP9Y	2491	O00507
PYLNPPDSTHPSPPS	SLC35G6	6	P0C7Q6
ERPAEPLTPPPSYGH	TGFB1I1	26	O43294
TVPSQEYSHPLPPTP	TRIM8	496	Q9BZR9
EYSHPLPPTPSVPQS	TRIM8	501	Q9BZR9
PVPVANYPHSPVPGN	ZMIZ1	501	Q9ULJ6
LPPYPEHLTSPLSPA	ZNF783	226	Q6ZMS7