Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

NCOA3 EBF1 HOXC10 LHX4 DMRT2 FOXA2 PBX3 EBF3

1.27e-05560408GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

NCOA3 EBF1 HOXC10 LHX4 DMRT2 FOXA2 PBX3 EBF3

1.37e-05566408GO:0001216
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

NCOA1 NCOA3 KLF18 EBF1 HOXC10 LHX4 DMRT2 FOXA2 PBX3 RBMXL1 EBF3 RBMX

1.80e-0514594012GO:0000977
GeneOntologyMolecularFunctionnuclear receptor coactivator activity

NCOA1 NCOA3 MED13

2.47e-0461403GO:0030374
GeneOntologyMolecularFunctiontranscription coactivator activity

NCOA1 NCOA3 MAML2 ARID1A MED13

3.31e-04303405GO:0003713
GeneOntologyMolecularFunctionnuclear receptor binding

NCOA1 NCOA3 ARID1A MED13

5.23e-04187404GO:0016922
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

KLF18 EBF1 HOXC10 DMRT2 FOXA2 PBX3 RBMXL1 EBF3 RBMX

6.47e-041244409GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

KLF18 EBF1 HOXC10 DMRT2 FOXA2 PBX3 RBMXL1 EBF3 RBMX

7.56e-041271409GO:0000987
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

NCOA3 KLF18 EBF1 HOXC10 LHX4 DMRT2 FOXA2 PBX3 EBF3

1.59e-031412409GO:0000981
GeneOntologyMolecularFunctionnuclear thyroid hormone receptor binding

NCOA3 MED13

2.11e-0334402GO:0046966
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

NCOA1 NCOA3 EBF1 MAML2 EYA1 HOXC10 SLC11A1 LHX4 DMRT2 FOXA2 PBX3 RBMXL1 EBF3 MED13 RBMX

8.80e-0913903815GO:0045944
GeneOntologyBiologicalProcessembryonic morphogenesis

NCOA1 NCOA3 HSPG2 EYA1 HOXC10 ARID1A FOXA2 KIF16B

3.82e-05713388GO:0048598
GeneOntologyBiologicalProcessneuron fate specification

EYA1 HOXC10 FOXA2

6.30e-0542383GO:0048665
GeneOntologyBiologicalProcessformation of primary germ layer

EYA1 ARID1A FOXA2 KIF16B

7.84e-05124384GO:0001704
GeneOntologyBiologicalProcesscarbon catabolite activation of transcription from RNA polymerase II promoter

NCOA1 FOXA2

9.19e-058382GO:0000436
GeneOntologyBiologicalProcesscarbon catabolite regulation of transcription from RNA polymerase II promoter

NCOA1 FOXA2

1.18e-049382GO:0000429
GeneOntologyBiologicalProcesscarbon catabolite activation of transcription

NCOA1 FOXA2

1.18e-049382GO:0045991
GeneOntologyBiologicalProcesscarbon catabolite regulation of transcription

NCOA1 FOXA2

1.47e-0410382GO:0045990
GeneOntologyBiologicalProcessembryo development

NCOA1 NCOA3 HSPG2 EYA1 HOXC10 DMRT2 ARID1A FOXA2 PBX3 KIF16B

2.03e-0414373810GO:0009790
GeneOntologyCellularComponentsupraspliceosomal complex

RBMXL1 RBMX

2.03e-054392GO:0044530
GeneOntologyCellularComponentgamma-delta T cell receptor complex

TRGC1 TRGC2

5.06e-056392GO:0042106
GeneOntologyCellularComponentchromatin

NCOA1 NCOA3 EBF1 HOXC10 LHX4 DMRT2 ARID1A FOXA2 PBX3 EBF3 RBMX

5.69e-0514803911GO:0000785
MousePhenoabnormal gland development

NCOA1 NCOA3 ERBB3 EYA1 LHX4 SEC23B

6.93e-06233296MP:0020973
MousePhenoperinatal lethality

HSPG2 ERBB3 EYA1 LHX4 DMRT2 ARID1A FOXA2 PBX3 EBF3 SEC23B

5.51e-0511302910MP:0002081
MousePhenoperinatal lethality, complete penetrance

ERBB3 EYA1 LHX4 DMRT2 ARID1A PBX3 EBF3 SEC23B

7.19e-05712298MP:0011089
MousePhenoabnormal circulating glucagon level

NCOA3 GLS2 FOXA2

7.53e-0540293MP:0002695
DomainDUF1518

NCOA1 NCOA3

1.14e-053372PF07469
DomainDUF1518

NCOA1 NCOA3

1.14e-053372IPR010011
DomainSrc1_rcpt_coact

NCOA1 NCOA3

1.14e-053372IPR008955
DomainNuclear_rcpt_coactivator

NCOA1 NCOA3

1.14e-053372IPR017426
DomainDUF1518

NCOA1 NCOA3

1.14e-053372SM01151
DomainNuc_rcpt_coact_Ncoa-typ

NCOA1 NCOA3

1.14e-053372IPR014920
DomainSRC-1

NCOA1 NCOA3

1.14e-053372IPR014935
DomainSRC-1

NCOA1 NCOA3

1.14e-053372PF08832
Domain-

NCOA1 NCOA3

1.14e-0533724.10.630.10
DomainNuc_rec_co-act

NCOA1 NCOA3

1.14e-053372PF08815
DomainTranscription_factor_COE

EBF1 EBF3

2.29e-054372IPR003523
DomainCOE1_HLH

EBF1 EBF3

2.29e-054372PF16423
DomainCOE1_DBD

EBF1 EBF3

2.29e-054372PF16422
DomainCOE_HLH

EBF1 EBF3

2.29e-054372IPR032201
DomainCOE_DBD

EBF1 EBF3

2.29e-054372IPR032200
DomainCOE

EBF1 EBF3

2.29e-054372PS01345
DomainTranscription_factor_COE_CS

EBF1 EBF3

2.29e-054372IPR018350
DomainNuc_rcpt_coact

NCOA1 NCOA3

5.70e-056372IPR009110
DomainHLH

NCOA1 NCOA3 EBF1 EBF3

7.96e-05116374SM00353
DomainRBM1CTR

RBMXL1 RBMX

1.06e-048372PF08081
DomainRBM1CTR

RBMXL1 RBMX

1.06e-048372IPR012604
DomainRRM_dom_euk

RBMXL1 RBMX

9.41e-0423372IPR003954
DomainRRM_1

RBMXL1 RBMX

9.41e-0423372SM00361
DomainPAS

NCOA1 NCOA3

1.11e-0325372PF00989
DomainPAS_fold

NCOA1 NCOA3

1.11e-0325372IPR013767
DomainIPT

EBF1 EBF3

1.30e-0327372SM00429
DomainTIG

EBF1 EBF3

1.71e-0331372PF01833
DomainPAS

NCOA1 NCOA3

1.82e-0332372SM00091
DomainIPT

EBF1 EBF3

1.82e-0332372IPR002909
DomainPAS

NCOA1 NCOA3

2.06e-0334372IPR000014
DomainPAS

NCOA1 NCOA3

2.06e-0334372PS50112
DomainLAM_G_DOMAIN

HSPG2 CNTNAP5

2.57e-0338372PS50025
DomainLaminin_G_2

HSPG2 CNTNAP5

2.84e-0340372PF02210
DomainLamG

HSPG2 CNTNAP5

3.43e-0344372SM00282
Domain-

ZCCHC2 KIF16B

4.58e-03513723.30.1520.10
DomainPhox

ZCCHC2 KIF16B

4.76e-0352372IPR001683
DomainLaminin_G

HSPG2 CNTNAP5

5.89e-0358372IPR001791
DomainHomeobox_CS

HOXC10 LHX4 PBX3

5.89e-03186373IPR017970
DomainRRM_1

RBMXL1 HNRNPF RBMX

8.01e-03208373PF00076
DomainRRM

RBMXL1 HNRNPF RBMX

8.99e-03217373SM00360
DomainConA-like_dom

HSPG2 CNTNAP5 RFPL3

9.21e-03219373IPR013320
DomainRRM_dom

RBMXL1 HNRNPF RBMX

1.02e-02227373IPR000504
DomainRRM

RBMXL1 HNRNPF RBMX

1.05e-02230373PS50102
DomainHomeobox

HOXC10 LHX4 PBX3

1.10e-02234373PF00046
DomainHOMEOBOX_1

HOXC10 LHX4 PBX3

1.13e-02236373PS00027
DomainHOX

HOXC10 LHX4 PBX3

1.14e-02237373SM00389
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION

NCOA1 NCOA3 EBF1 MED13

1.59e-0584264M1008
PathwayKEGG_MEDICUS_VARIANT_ESR1_POSITIVE_TO_NUCLEAR_INITIATED_ESTROGEN_SIGNALING_PATHWAY

NCOA1 NCOA3

3.26e-055262M48983
PathwayREACTOME_ADIPOGENESIS

NCOA1 NCOA3 EBF1 MED13

4.60e-05110264M48259
PathwayKEGG_MEDICUS_REFERENCE_NUCLEAR_INITIATED_ESTROGEN_SIGNALING_PATHWAY

NCOA1 NCOA3

1.78e-0411262M47503
PathwayPID_ERB_GENOMIC_PATHWAY

NCOA1 NCOA3

3.38e-0415262M119
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

NCOA1 NCOA3 EBF1 MAML2 EYA1 LHX4 ARID1A FOXA2 MED13

7.06e-041432269M509
PathwayBIOCARTA_VDR_PATHWAY

NCOA3 ARID1A

7.39e-0422262MM1370
PathwayBIOCARTA_VDR_PATHWAY

NCOA1 ARID1A

8.81e-0424262M13404
Pubmed

A census of human transcription factors: function, expression and evolution.

NCOA1 NCOA3 EBF1 HOXC10 LHX4 DMRT2 FOXA2 PBX3 EBF3

7.16e-0790840919274049
Pubmed

Polymorphism of Tcrb and Tcrg genes in Biozzi mice: segregation analysis of a new Tcrg haplotype with antibody responsiveness.

TRGC1 TRGC2

1.29e-0624021973682
Pubmed

T cell-specific gamma genes in C57BL/10 mice. Sequence and expression of new constant and variable region genes.

TRGC1 TRGC2

1.29e-0624023486244
Pubmed

The coactivator SRC-1 is an essential coordinator of hepatic glucose production.

NCOA1 NCOA3

1.29e-06240221109193
Pubmed

Steroid receptor coactivator (SRC)-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptor.

NCOA1 NCOA3

1.29e-06240216141356
Pubmed

Immunohistochemical localization of steroid receptor coactivators in chondrosarcoma: an in vivo tissue microarray study.

NCOA1 NCOA3

1.29e-06240224875297
Pubmed

Developmentally ordered V-J recombination in mouse T cell receptor gamma locus is not perturbed by targeted deletion of the Vgamma4 gene.

TRGC1 TRGC2

1.29e-0624029126983
Pubmed

Limited diversity of the rearranged T-cell gamma gene.

TRGC1 TRGC2

1.29e-0624023871915
Pubmed

Mapping genomic organization by field inversion and two-dimensional gel electrophoresis: application to the murine T-cell receptor gamma gene family.

TRGC1 TRGC2

1.29e-0624023375073
Pubmed

Structure, organization, and somatic rearrangement of T cell gamma genes.

TRGC1 TRGC2

1.29e-0624023917858
Pubmed

Allelic differences in TCR gamma-chains alter gamma delta T cell antigen reactivity.

TRGC1 TRGC2

1.29e-0624028046225
Pubmed

Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance.

NCOA1 NCOA3

1.29e-06240216459312
Pubmed

Physical linkage of mouse Tcrg-V genes. II. Regulatory features of the Vg4-Vg3 intergenic region.

TRGC1 TRGC2

1.29e-0624028119740
Pubmed

Organization of the murine T-cell receptor gamma locus.

TRGC1 TRGC2

1.29e-0624028244371
Pubmed

The genomic arrangement of T cell receptor variable genes is a determinant of the developmental rearrangement pattern.

TRGC1 TRGC2

1.29e-06240214691262
Pubmed

New T-cell receptor gamma haplotypes in wild mice and evidence for limited Tcrg-V gene polymorphism.

TRGC1 TRGC2

1.29e-0624028420824
Pubmed

Conservation of Tcrg-V5 and limited allelic sequence polymorphism of the other Tcrg-V genes used by mouse tissue-specific gd-T lymphocytes.

TRGC1 TRGC2

1.29e-0624028550103
Pubmed

Role of accessory factors and steroid receptor coactivator 1 in the regulation of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids.

NCOA1 FOXA2

1.29e-06240211069927
Pubmed

Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cells.

NCOA1 NCOA3 FOXA2

2.46e-062340319737349
Pubmed

The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles.

NCOA1 NCOA3

3.87e-06340221035760
Pubmed

Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia.

RBMXL1 RBMX

3.87e-06340234458856
Pubmed

Distinctive functions of p160 steroid receptor coactivators in proliferation of an estrogen-independent, tamoxifen-resistant breast cancer cell line.

NCOA1 NCOA3

3.87e-06340221059860
Pubmed

RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet.

RBMXL1 RBMX

3.87e-06340217188681
Pubmed

Langerhans cells are not required for epidermal Vgamma3 T cell homeostasis and function.

TRGC1 TRGC2

3.87e-06340221486908
Pubmed

Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1.

NCOA1 NCOA3

3.87e-0634029832502
Pubmed

Absence of the steroid receptor coactivator-3 induces B-cell lymphoma.

NCOA1 NCOA3

3.87e-06340216675958
Pubmed

Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene.

NCOA1 NCOA3

3.87e-0634029506940
Pubmed

Steroid receptor coactivators present a unique opportunity for drug development in hormone-dependent cancers.

NCOA1 NCOA3

3.87e-06340228390937
Pubmed

The characterization of the Olf-1/EBF-like HLH transcription factor family: implications in olfactory gene regulation and neuronal development.

EBF1 EBF3

3.87e-0634029151732
Pubmed

RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene.

RBMXL1 RBMX

3.87e-06340210391207
Pubmed

A mutant form of ERα associated with estrogen insensitivity affects the coupling between ligand binding and coactivator recruitment.

NCOA1 NCOA3

3.87e-06340232963012
Pubmed

Research resource: loss of the steroid receptor coactivators confers neurobehavioral consequences.

NCOA1 NCOA3

3.87e-06340223927929
Pubmed

Expression and significance of androgen receptor coactivators in urothelial carcinoma of the bladder.

NCOA1 NCOA3

3.87e-06340218845648
Pubmed

The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP.

NCOA1 NCOA3

3.87e-06340212138202
Pubmed

Structure and chromosomal locations of mouse steroid receptor coactivator gene family.

NCOA1 NCOA3

3.87e-06340210501088
Pubmed

Estradiol increases cell growth in human astrocytoma cell lines through ERα activation and its interaction with SRC-1 and SRC-3 coactivators.

NCOA1 NCOA3

3.87e-06340222142990
Pubmed

The transcriptional coactivators p/CIP and SRC-1 control insulin resistance through IRS1 in obesity models.

NCOA1 NCOA3

3.87e-06340222859932
Pubmed

The steroid receptor coactivator-1 regulates twist expression and promotes breast cancer metastasis.

NCOA1 NCOA3

3.87e-06340219383905
Pubmed

Genetic polymorphism and exon changes of the constant regions of the human T-cell rearranging gene gamma.

TRGC1 TRGC2

3.87e-0634022879283
Pubmed

The genomic analysis of the impact of steroid receptor coactivators ablation on hepatic metabolism.

NCOA1 NCOA3

3.87e-06340216423883
Pubmed

Dlx1/2 are Central and Essential Components in the Transcriptional Code for Generating Olfactory Bulb Interneurons.

EBF1 PBX3 EBF3

4.53e-062840330796806
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

NCOA1 NCOA3 ARID1A HNRNPF ZMYM4

5.32e-0622040535785414
Pubmed

miR-137 Targets p160 Steroid Receptor Coactivators SRC1, SRC2, and SRC3 and Inhibits Cell Proliferation.

NCOA1 NCOA3

7.73e-06440226066330
Pubmed

Steroid receptor coactivator-1 and its family members differentially regulate transactivation by the tumor suppressor protein p53.

NCOA1 NCOA3

7.73e-06440210551785
Pubmed

P160/SRC/NCoA coactivators form complexes via specific interaction of their PAS-B domain with the CID/AD1 domain.

NCOA1 NCOA3

7.73e-06440218267973
Pubmed

Selective recruitment of p160 coactivators on glucocorticoid-regulated promoters in Schwann cells.

NCOA1 NCOA3

7.73e-06440215331759
Pubmed

Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development.

EBF1 EBF3

7.73e-0644029151733
Pubmed

Unique roles of p160 coactivators for regulation of breast cancer cell proliferation and estrogen receptor-alpha transcriptional activity.

NCOA1 NCOA3

7.73e-06440219095746
Pubmed

Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy.

NCOA1 NCOA3

7.73e-06440222560224
Pubmed

SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene.

RBMXL1 RBMX

7.73e-06440219403048
Pubmed

Cloning of a novel Olf-1/EBF-like gene, O/E-4, by degenerate oligo-based direct selection.

EBF1 EBF3

7.73e-06440212139918
Pubmed

Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death.

NCOA1 NCOA3

7.73e-06440226267537
Pubmed

The ratio of FoxA1 to FoxA2 in lung adenocarcinoma is regulated by LncRNA HOTAIR and chromatin remodeling factor LSH.

SLC11A1 FOXA2

7.73e-06440226658322
Pubmed

Mutation of a lysine residue in a homeodomain generates dominant negative thyroid transcription factor 1.

NCOA1 NCOA3

7.73e-06440215449938
Pubmed

Nuclear receptor coregulator SNP discovery and impact on breast cancer risk.

NCOA1 NCOA3

7.73e-06440220003447
Pubmed

Nuclear hormone receptor coregulator GRIP1 suppresses, whereas SRC1A and p/CIP coactivate, by domain-specific binding of MyoD.

NCOA1 NCOA3

7.73e-06440215563453
Pubmed

Global proteomics of Ubqln2-based murine models of ALS.

SMAP2 SPTLC2 CNN2 SEC23B ANXA11

1.22e-0526140533277362
Pubmed

Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene.

NCOA1 NCOA3

1.29e-05540210652338
Pubmed

Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22.

TRGC1 TRGC2

1.29e-05540215821084
Pubmed

Redundant enhancement of mouse constitutive androstane receptor transactivation by p160 coactivator family members.

NCOA1 NCOA3

1.29e-05540217950690
Pubmed

SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm.

NCOA1 NCOA3

1.29e-05540217476305
Pubmed

Ontogeny of steroid receptor coactivators in the hippocampus and their role in regulating postnatal HPA axis function.

NCOA1 NCOA3

1.29e-05540217854779
Pubmed

Dual role of the arginine methyltransferase CARM1 in the regulation of c-Fos target genes.

NCOA1 NCOA3

1.29e-05540218511550
Pubmed

Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor-alpha: regulation by phosphorylation sites in the A/B region depends on other receptor domains.

NCOA1 NCOA3

1.29e-05540212714702
Pubmed

Transcription factor-specific requirements for coactivators and their acetyltransferase functions.

NCOA1 NCOA3

1.29e-0554029445475
Pubmed

Regulation of transcription by a protein methyltransferase.

NCOA1 NCOA3

1.29e-05540210381882
Pubmed

SRC-1 null mice exhibit moderate motor dysfunction and delayed development of cerebellar Purkinje cells.

NCOA1 NCOA3

1.29e-05540212514218
Pubmed

Ligands specify coactivator nuclear receptor (NR) box affinity for estrogen receptor subtypes.

NCOA1 NCOA3

1.29e-05540211376110
Pubmed

Formation of whisker-related principal sensory nucleus-based lemniscal pathway requires a paired homeodomain transcription factor, Drg11.

EBF1 EBF3

1.29e-05540212917357
Pubmed

Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor.

NCOA1 NCOA3

1.29e-05540218798693
Pubmed

Isoform-selective interactions between estrogen receptors and steroid receptor coactivators promoted by estradiol and ErbB-2 signaling in living cells.

NCOA1 NCOA3

1.29e-05540212554772
Pubmed

SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4.

NCOA1 NCOA3

1.29e-0554029812974
Pubmed

The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding.

NCOA1 NCOA3

1.29e-05540210757795
Pubmed

Lysine 246 of the vitamin D receptor is crucial for ligand-dependent interaction with coactivators and transcriptional activity.

NCOA1 NCOA3

1.29e-05540210224118
Pubmed

Stem cell niche-specific Ebf3 maintains the bone marrow cavity.

EBF1 EBF3

1.29e-05540229563184
Pubmed

Coactivator and corepressor gene expression in rat cerebellum during postnatal development and the effect of altered thyroid status.

NCOA1 NCOA3

1.29e-05540210803578
Pubmed

Expression patterns of the coe/ebf transcription factor genes during chicken and mouse limb development.

EBF1 EBF3

1.29e-05540215261831
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

NCOA1 EBF1 HOXC10 ARID1A PBX3 EBF3 RFPL3

1.48e-0570940722988430
Pubmed

The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety.

NCOA1 NCOA3 HOXC10

1.68e-054340326487511
Pubmed

Temporal/spatial expression of nuclear receptor coactivators in the mouse lung.

NCOA1 NCOA3

1.93e-05640211076796
Pubmed

T cell receptor signaling for γδT cell development.

TRGC1 TRGC2

1.93e-05640230976362
Pubmed

A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro.

NCOA1 NCOA3

1.93e-05640216373399
Pubmed

Mutual antagonism of estrogen receptors alpha and beta and their preferred interactions with steroid receptor coactivators in human osteoblastic cell lines.

NCOA1 NCOA3

1.93e-05640212630920
Pubmed

Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins.

NCOA1 NCOA3

1.93e-05640210777539
Pubmed

Discrete roles for peroxisome proliferator-activated receptor gamma and retinoid X receptor in recruiting nuclear receptor coactivators.

NCOA1 NCOA3

1.93e-05640211027271
Pubmed

Roles of coactivators in hypoxic induction of the erythropoietin gene.

NCOA1 NCOA3

1.93e-05640220368990
Pubmed

Steroid receptor coactivator-3 is required for progesterone receptor trans-activation of target genes in response to gonadotropin-releasing hormone treatment of pituitary cells.

NCOA1 NCOA3

1.93e-05640216728408
Pubmed

Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly.

NCOA1 NCOA3

1.93e-05640216923966
Pubmed

The transcription factor, Lmx1b, is necessary for the development of the principal trigeminal nucleus-based lemniscal pathway.

EBF1 EBF3

1.93e-05640220621716
Pubmed

Family of Ebf/Olf-1-related genes potentially involved in neuronal differentiation and regional specification in the central nervous system.

EBF1 EBF3

1.93e-0564029389446
Pubmed

Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption.

NCOA1 NCOA3

2.70e-05740221195347
Pubmed

BRCA1-IRIS regulates cyclin D1 expression in breast cancer cells.

NCOA1 NCOA3

2.70e-05740216860316
Pubmed

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function.

NCOA1 NCOA3

2.70e-0574029192892
Pubmed

Temporal formation of distinct thyroid hormone receptor coactivator complexes in HeLa cells.

NCOA1 NCOA3

2.70e-05740211117530
Pubmed

Isotype-restricted corepressor recruitment: a constitutively closed helix 12 conformation in retinoic acid receptors beta and gamma interferes with corepressor recruitment and prevents transcriptional repression.

NCOA1 NCOA3

2.70e-05740212665583
Pubmed

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

EBF1 EYA1

2.70e-05740224688116
Pubmed

Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1.

EBF1 EBF3

2.70e-05740224786561
Pubmed

Associations and interactions between Ets-1 and Ets-2 and coregulatory proteins, SRC-1, AIB1, and NCoR in breast cancer.

NCOA1 NCOA3

2.70e-05740215788656
Pubmed

Stoichiometry of the murine gammadelta T cell receptor.

TRGC1 TRGC2

2.70e-05740216418397
Pubmed

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk.

TRGC1 TRGC2

2.70e-0574027477352
InteractionCARM1 interactions

NCOA1 NCOA3 ARID1A HNRNPF SEC23B KIF16B

2.56e-05325376int:CARM1
InteractionEBF4 interactions

EBF1 EBF3

6.85e-057372int:EBF4
InteractionRARB interactions

NCOA1 NCOA3 ARID1A

8.19e-0546373int:RARB
InteractionRORB interactions

NCOA1 NCOA3 ANKS1A

8.74e-0547373int:RORB
InteractionNR1I3 interactions

NCOA1 NCOA3 MED13

9.31e-0548373int:NR1I3
InteractionCREBBP interactions

NCOA1 NCOA3 EBF1 MAML2 ARID1A RFPL3 ANKS1A

9.38e-05599377int:CREBBP
InteractionCRX interactions

NCOA1 NCOA3 ARID1A SMAP2 ZMYM4

9.58e-05254375int:CRX
InteractionHNF4A interactions

NCOA1 NCOA3 ARID1A FOXA2 ZMYM4

1.39e-04275375int:HNF4A
InteractionNCOA1 interactions

NCOA1 NCOA3 ARID1A FOXA2

1.45e-04146374int:NCOA1
InteractionRARG interactions

NCOA1 NCOA3 ARID1A

1.64e-0458373int:RARG
InteractionKLF15 interactions

NCOA1 NCOA3 HNRNPF ZMYM4 ANKS1A

1.78e-04290375int:KLF15
Cytoband7p14

TRGC1 TRGC2

3.17e-04304027p14
Cytoband20p11.23

SEC23B KIF16B

4.08e-043440220p11.23
Cytoband12q13

ERBB3 GLS2

1.77e-037140212q13
CytobandEnsembl 112 genes in cytogenetic band chr1p34

KLF18 SMAP2 ZMYM4

2.16e-03294403chr1p34
CytobandEnsembl 112 genes in cytogenetic band chr12q13

ERBB3 HOXC10 GLS2

5.96e-03423403chr12q13
CytobandEnsembl 112 genes in cytogenetic band chr20p11

FOXA2 SEC23B

7.92e-03153402chr20p11
CytobandEnsembl 112 genes in cytogenetic band chr7p14

TRGC1 TRGC2

1.01e-02174402chr7p14
CytobandEnsembl 112 genes in cytogenetic band chr18q21

ATP8B1 ZCCHC2

1.38e-02205402chr18q21
CytobandEnsembl 112 genes in cytogenetic band chr10q26

EBF3 EDRF1

1.41e-02207402chr10q26
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

NCOA1 NCOA3

3.33e-0417292486
GeneFamilyT cell receptor gamma locus at 7p14

TRGC1 TRGC2

5.63e-0422292375
GeneFamilyRNA binding motif containing

RBMXL1 HNRNPF RBMX

4.70e-03213293725
GeneFamilyBasic helix-loop-helix proteins

NCOA1 NCOA3

1.34e-02110292420
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MCC CNTNAP5 DMRT2 SPTLC2 ANKS1A

4.17e-071694052a21f2cef959526bfe3c8f081f4f7e9dd4e01a37
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MCC CNTNAP5 DMRT2 SPTLC2 ANKS1A

4.68e-071734050bc2aacae60c6d3276b0949eb0748b4ac1f56e54
ToppCellmetastatic_Brain-Myeloid_cells-Alveolar_Mac|Myeloid_cells / Location, Cell class and cell subclass

PCOLCE2 SLC11A1 TRGC1 ANXA11 TRGC2

6.87e-071874057375f70a970a5d5a58b7c33ada2dcf6dcef525c6
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MAML2 EYA1 TMEM132D SPTLC2

1.89e-05177404da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MCC CNTNAP5 DMRT2 SPTLC2

1.89e-05177404f35b04c3557ebbdeba37dec54c8f45880eafb422
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAML2 EYA1 TMEM132D SPTLC2

2.07e-05181404071f9bb5d39070cdc473d9b0e094d196bc702b56
ToppCell10x5'v1-week_14-16-Mesenchymal_osteo-stroma-chondrocyte|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

PCOLCE2 ERBB3 HOXC10 FOXA2

2.30e-0518640480a0a42ca8585cdb1dda57a18c254316a126ee64
ToppCellControl-Myeloid-Macrophage_Alveolar|Control / Disease state, Lineage and Cell class

PCOLCE2 SLC11A1 ANKS1A KIF16B

2.45e-05189404937e876122bc4b94372a4104e9c1a9068c232018
ToppCellCOVID-19-Heart-EC_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

MCC HSPG2 EBF1 EBF3

2.45e-05189404fe49852ba15f948b384d6b4c258927c70b741357
ToppCellCOVID-19-Heart-T_cell|Heart / Disease (COVID-19 only), tissue and cell type

CNTNAP5 TMEM132D TRGC1 TRGC2

2.50e-05190404e6c3a6e01fef6c5b49f72661d4fb0414ba9046bf
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ERBB3 ATP8B1 EYA1 TMEM132D

2.55e-0519140460ff989fe99d243a3d52955223680cdd1f1917a4
ToppCellCTRL-Myeloid-Alveolar_Macrophage|Myeloid / Disease state, Lineage and Cell class

PCOLCE2 SLC11A1 ANKS1A KIF16B

2.66e-0519340480871d963c23a6befe58e5e60b7f7d1a1b227ce2
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

ARID1A SPTLC2 MED13 ZMYM4

2.66e-05193404abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellMacrophages-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

PCOLCE2 SLC11A1 TRGC1 TRGC2

2.71e-0519440454fda501ce1d041285d04c3c96c15983f454bed4
ToppCell10x3'2.3-week_17-19-Mesenchymal_osteo-stroma-osteoblast_precursor|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PCOLCE2 HOXC10 DMRT2 EBF3

2.77e-05195404ec12cfb2fce44cc2de4e198ef5af075e626f0329
ToppCellSepsis-URO|Sepsis / Disease, condition lineage and cell class

PCOLCE2 SLC11A1 SMAP2 TRGC1

3.00e-051994048e6dac82d1d0e759cd567f9c95b70cb4801d7caf
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-CR-CR_Lhx5|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

EBF1 EYA1 EBF3

6.33e-05864032990429ed4438f41ff03f4a9cae8863a528fdd81
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-CR|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

EBF1 EYA1 EBF3

6.33e-058640397467708c90a4bd49deafe3e2ec495c56b448ce1
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CNTNAP5 DMRT2 SPTLC2

2.51e-0413740381cdb216e6c81acf9c2072f9d39e1a42612e1258
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 EBF1 EBF3

2.62e-04139403b07929348ec9ad95d7bce33a7deac0938227b19f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MCC CNTNAP5 DMRT2

3.03e-04146403e887e9de895fd453faa703997ef372cc6410fc49
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CNTNAP5 TRGC1 TRGC2

3.09e-0414740322c9605869dd2e789896cd2790ee8def2605de57
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1|368C / Donor, Lineage, Cell class and subclass (all cells)

EDRF1 TRGC1 TRGC2

3.09e-04147403743767abdb3b5ecad870b617f515b037ce280818
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CNTNAP5 TRGC1 TRGC2

3.09e-04147403ac272595818d25c6b84b107555b3351e912a01a7
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-SMC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ATP8B1 EBF1 CNN2

3.15e-04148403e514b7cf412ddbee249894e089e2204c67bcdbce
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

EDRF1 TRGC1 TRGC2

3.15e-04148403e7bbb5ddf44b11b8495e83863fbf1fd9f3f24472
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ATP8B1 DMRT2 TRGC2

3.21e-0414940368661c8facfb638560bb2e2c20d509941286dacb
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|390C / Donor, Lineage, Cell class and subclass (all cells)

DMRT2 TRGC1 TRGC2

3.47e-04153403ce7a23c687e9e7d83d244046de19c854caded09b
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac1_Htr1d|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CNTNAP5 EYA1 DMRT2

3.61e-0415540379264ff283e36a059040a5aa9fe7337be694cb52
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

EDRF1 TRGC1 TRGC2

3.68e-04156403c11ca6b1b5029c15aab91273cece70a487287839
ToppCellChildren_(3_yrs)-Epithelial-basal_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

MCC EYA1 DMRT2

3.82e-04158403d78e7e52657dc094430291fec07e9c298be9e584
ToppCellCOVID-19-kidney-Epithelial_(EC)|kidney / Disease (COVID-19 only), tissue and cell type

HSPG2 EBF1 TMEM132D

3.96e-041604030d4880f85565d8c540c94a8f8109147b3029279a
ToppCellICU-SEP-Lymphocyte-T_NK-gdT|ICU-SEP / Disease, Lineage and Cell Type

ERBB3 TRGC1 TRGC2

3.96e-041604030a14b1fed54a09c0caf263662b5bd426466c7189
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Calb2_Pdlim5|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MCC EYA1 DMRT2

4.03e-04161403bf70be1de418615b5442ec684552551edaf1f072
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ERBB3 ATP8B1 EYA1

4.03e-041614032d63b279d9a5132e1c09b03930bf9039036d24a2
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PCOLCE2 EBF1 EBF3

4.03e-041614034f25eeabb841b0b9204cdd4e71d5e131e7868184
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PCOLCE2 EBF1 EBF3

4.03e-04161403a006491c991e6a134be20ad75092a91f3b7c3c91
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ERBB3 DMRT2 TMEM132D

4.25e-041644033caf4cdaa0164907893fea61e251fd8b5fa926e4
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EBF1 EXTL2 TRGC2

4.33e-04165403e2aebb2fe197151e019371b8960f76f0c2386f08
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EBF1 EXTL2 TRGC2

4.33e-04165403b087771499aeb31cc4a338d2d0a9392a4ec1ac45
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EBF1 EXTL2 TRGC2

4.33e-04165403d8f8b088fd28a6b9dbd6b51bcaee42000e963321
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

FOXA2 PBX3 EBF3

4.41e-041664036a6ed5c7a43fee9a8a9be42dfa99303815b8e8ef
ToppCellwk_20-22-Epithelial-Airway_epithelial_progenitor|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ERBB3 FOXA2 TMEM132D

4.41e-04166403fcd0bd70b553789092249806ace324b77bd10481
ToppCellwk_20-22-Epithelial-Airway_epithelial_progenitor-epi-stalk_late|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ERBB3 FOXA2 TMEM132D

4.41e-04166403b60954e5625743657d0fd9264b738b46e72fd8a6
ToppCelldroplet-Marrow-BM-30m-Hematologic-proerythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC11A1 CNN2 ANXA11

4.49e-04167403f90cf0f29c14df4f211193326699e599ef955fa4
ToppCell3'_v3-GI_small-bowel-Lymphocytic_B-Memory_B_cells|GI_small-bowel / Manually curated celltypes from each tissue

NCOA3 EBF1 SMAP2

4.56e-041684038e025bb0541746e232b77ac0e31412ae71420c47
ToppCell3'_v3-GI_small-bowel-Lymphocytic_B|GI_small-bowel / Manually curated celltypes from each tissue

NCOA3 EBF1 SMAP2

4.56e-041684035535c1b8b7fde7b59a1bc0580cebdfa963aa1c39
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCOLCE2 EBF1 HOXC10

4.64e-04169403bb43abad2c049b7f4d307737347290e01b3339a3
ToppCellfacs-Liver-Non-hepatocytes-3m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCOLCE2 SLC11A1 TMEM132D

4.64e-0416940344d841fd997a6f26104f16cd00223ecce8352f43
ToppCell356C-Epithelial_cells-Epithelial-D_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PCOLCE2 SLC11A1 TRGC2

4.64e-04169403818ab7a6fd1940a22d3bd99fe15f0af888af6b3e
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCOLCE2 EBF1 HOXC10

4.64e-041694035f18e3f40a5b1b167903f37516ec8181e889c7c5
ToppCell356C-Epithelial_cells-Epithelial-D_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PCOLCE2 SLC11A1 TRGC2

4.64e-04169403f982f2e0d341fa27229f443ebe5c0e4a9e63bda6
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCOLCE2 EBF1 HOXC10

4.64e-041694038bfa2d3bb541d02f55d7c95b8fd156c8403befca
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic-Paneth|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ATP8B1 FOXA2 TRGC2

4.64e-04169403a2f521f68681c0358448fa68329df764659ff52c
ToppCellRA-01._Fibroblast_I|RA / Chamber and Cluster_Paper

PCOLCE2 EBF1 MAML2

4.64e-041694036373562ab3b1765060212a6a53d6543e7e942e80
ToppCellChildren_(3_yrs)-Immune-B_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

NCOA3 EBF1 SMAP2

4.72e-04170403e421f9eedf74baffda1d03707a710ece4b777f29
ToppCelldroplet-Marrow-nan-24m-Hematologic-proerythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC11A1 CNN2 ANXA11

4.81e-04171403b3ea26d181f91ea07074f403e7dca9b6b671b1a2
ToppCellCOVID-19-kidney-Bcells|COVID-19 / Disease (COVID-19 only), tissue and cell type

NCOA3 EBF1 SMAP2

4.81e-041714038e8fb79968b1a5c34d1d9cad7f9155fabfdb7cc7
ToppCellControl-Endothelial_cells-Systemic_venous_endothelial_cells|Control / group, cell type (main and fine annotations)

HSPG2 ATP8B1 EBF3

4.89e-04172403c55dce1ed3ed7312394b4e050e1de852a994e130
ToppCell3'-Airway_Nasal-Endothelial-Blood_vessel_EC|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HSPG2 EBF1 EBF3

4.97e-04173403b7d8702409b86fbc8741a472b84d509ba261a852
ToppCell5'-Adult-Distal_Rectal-Hematopoietic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EYA1 SLC11A1 SMAP2

4.97e-04173403b335ca2a247156eba821943b2b9fc9922230b409
ToppCell367C-Lymphocytic-ILC-ILC-2|367C / Donor, Lineage, Cell class and subclass (all cells)

ZMYM4 TRGC1 TRGC2

4.97e-041734030451450605521fecb27a958628870d268adfb023
ToppCell3'-Airway_Nasal-Endothelial|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HSPG2 EBF1 EBF3

4.97e-04173403383edcd3bb14d3934506260dbbac7167282546af
ToppCell3'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HSPG2 EBF1 EBF3

4.97e-04173403b83c9e274999c9325908616cee4a89d425c8c4ed
ToppCell3'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HSPG2 EBF1 EBF3

4.97e-041734030068c059ef118b5ef85c5b01ad8680ce11493aa5
ToppCell3'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HSPG2 EBF1 EBF3

4.97e-041734033c96e269ca7b7029f533268f68ca4466edd20edd
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HSPG2 ERBB3 HOXC10

4.97e-04173403789ab8b2709f4b8728e3733bc72744e9d92ea5ea
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HSPG2 EBF1 EBF3

5.06e-0417440318ab52d8bbca0507fee220e0c4fc765fc47dda34
ToppCellwk_15-18-Epithelial-Distal_epithelial-type_I_pneumocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

HSPG2 ERBB3 FOXA2

5.06e-041744032cd6638b361ca05ab83d09ce657194aed97873b7
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCOLCE2 SLC11A1 TRGC2

5.06e-04174403048febe84566666234bad24c58c28b7e1e2f8381
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CNTNAP5 DMRT2 SPTLC2

5.06e-041744035f4436863a40f8bca46e2989bca66c02b6be88d4
ToppCell356C-Lymphocytic-ILC|356C / Donor, Lineage, Cell class and subclass (all cells)

DMRT2 TRGC1 TRGC2

5.14e-041754037fa8330ce813c48bd332be618909e5ec8d0f5d7e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CNTNAP5 DMRT2 SPTLC2

5.14e-0417540377c16e615c0fb9c83f29d7e0a547be72635fac81
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RBMX TRGC1 TRGC2

5.23e-04176403dca70f309af24421f8dc708cbd88512814b8e79e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CNTNAP5 DMRT2 SPTLC2

5.23e-0417640325ebc8716aa44e44fce577701e3e82c6745a75ab
ToppCellAdult-Immune-B_cell|Adult / Lineage, Cell type, age group and donor

NCOA3 EBF1 SMAP2

5.23e-041764034aa00dcde907ad83d3aa4bb10439b7b5c4be1e5d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CNTNAP5 DMRT2 SPTLC2

5.23e-04176403c2c4306476989bc2fb30dab00250ef7915842f13
ToppCellAT1_cells-HP_01|World / lung cells shred on cell class, cell subclass, sample id

HSPG2 TMEM132D ANKS1A

5.23e-04176403458720776b0151cd55acc352d509599cb62f0ca8
ToppCellfacs-Large_Intestine-Proximal-24m-Epithelial-epithelial_cell_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCOLCE2 EBF1 MAML2

5.23e-04176403e29a13b8152ee84ca82fd1158d96d3f112e3cde3
ToppCellfacs-Large_Intestine-Proximal-24m-Epithelial-Lgr5-_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCOLCE2 EBF1 MAML2

5.23e-0417640300510bf8ede0945dfcbd58cc8f34fddf914b6e49
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MAML2 EYA1 TMEM132D

5.23e-04176403327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCellControl-B_cells|Control / group, cell type (main and fine annotations)

NCOA3 EBF1 SMAP2

5.23e-041764039125caa27bf790f6b1b960a86c09b4bcb1b58641
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MCC PCOLCE2 DMRT2

5.31e-041774030721199be6d29777dc0f47845aafd027fd376a32
ToppCellCOVID-19-lung-B_cells|lung / Disease (COVID-19 only), tissue and cell type

NCOA3 EBF1 SMAP2

5.31e-04177403f54691e5558091c1734ab15153a10bff15ed171e
ToppCellfacs-Lung-nan-3m-Epithelial-club_cell_of_bronchiole|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERBB3 EYA1 FOXA2

5.31e-04177403e5070934c674a46e070b0d52b9a374516bf6aea1
ToppCellCOVID-19-B_cells-Activated_B_cells|COVID-19 / group, cell type (main and fine annotations)

NCOA3 EBF1 SMAP2

5.31e-04177403653bb62a3744d4024ab3186ee01d410ed62832a6
ToppCellfacs-Lung-nan-3m-Epithelial-Club_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERBB3 EYA1 FOXA2

5.31e-04177403b37d821f4f3204daf7c568ac17a0af0ba97273d6
ToppCellChildren_(3_yrs)-Epithelial-basal_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

MCC EYA1 DMRT2

5.40e-04178403fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MCC MAML2 EYA1

5.40e-04178403e86ed30652c2de70f16430f04b78789b87df4af2
ToppCellPND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HSPG2 ERBB3 FOXA2

5.40e-04178403a3af5d9c55858e36be0498081029ecb0acaeb3d3
ToppCellPND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HSPG2 ERBB3 FOXA2

5.40e-04178403b3b88989bd602cfb55bb5c47731deb99288a8952
ToppCell356C-Lymphocytic-ILC-ILC-1|356C / Donor, Lineage, Cell class and subclass (all cells)

DMRT2 TRGC1 TRGC2

5.40e-0417840340df4bb0978e5e5568c52ad4a5881ea0cdc6941d
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-B_cell-B_cell|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NCOA3 EBF1 SMAP2

5.49e-04179403fad1fbee002fcd424c03460d695559060ce41a3f
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-B_cell|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NCOA3 EBF1 SMAP2

5.49e-041794036d4e4b64e633b2ae8514ffa1e45829d6508dac54
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-B_cell-B_cell-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NCOA3 EBF1 SMAP2

5.49e-0417940361a7cc01fae4115325fce0efaa5bacf8f9af5ba2
ToppCellLA-01._Fibroblast_I|LA / Chamber and Cluster_Paper

PCOLCE2 EBF1 MAML2

5.49e-04179403dcb6ec9ae72b13fe388b72dace2815293fafe8ee
ToppCellChildren_(3_yrs)-Immune-B_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

NCOA3 EBF1 SMAP2

5.58e-0418040340a12eb852373ae3d7c8d9bca376b0ae99f724b3
ToppCellIPF-Lymphoid-B|World / Disease state, Lineage and Cell class

NCOA3 EBF1 SMAP2

5.58e-0418040330f9398c9b784f49470847a025bac90687e997a1
ToppCellCOVID-19-kidney-Bcells|kidney / Disease (COVID-19 only), tissue and cell type

NCOA3 EBF1 SMAP2

5.58e-041804035650fc7ebcdf5e0be9a217a58d36a8386d59fd1b
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HSPG2 EBF1 GLS2

5.58e-0418040339ae8586efd91536e9ac6408d26de7e6d6237c41
DrugDroperidol [548-73-2]; Down 200; 10.6uM; HL60; HT_HG-U133A

NCOA1 ATP8B1 SLC11A1 ARID1A SPTLC2

1.99e-051953951290_DN
DrugRapamycin; Down 200; 0.1uM; HL60; HT_HG-U133A

NCOA1 NCOA3 PCOLCE2 PBX3 EDRF1

1.99e-051953951162_DN
DrugPiromidic acid [19562-30-2]; Down 200; 13.8uM; MCF7; HT_HG-U133A

HSPG2 GLS2 SPTLC2 EDRF1 ANXA11

1.99e-051953954398_DN
DrugOxolinic acid [14698-29-4]; Up 200; 15.4uM; PC3; HT_HG-U133A

MCC NCOA3 HOXC10 ARID1A FOXA2

2.09e-051973952103_UP
DrugSulfinpyrazone [57-96-5]; Down 200; 9.8uM; HL60; HG-U133A

NCOA1 PCOLCE2 ATP8B1 SLC11A1 SEC23B

2.25e-052003951574_DN
Diseaseceramide measurement

ATP8B1 SPTLC2 CNN2 RBMX KIF16B

1.42e-05235395EFO_0010222
DiseaseHypopituitarism

LHX4 FOXA2

1.70e-055392C0020635
DiseaseSarcoidosis

SLC11A1 ANXA11

4.74e-058392C0036202
Diseaseacute lymphoblastic leukemia, response to antineoplastic agent

NCOA3 MAML2

2.87e-0419392EFO_0000220, GO_0097327
Diseasemean platelet volume

EBF1 MAML2 GLS2 SMAP2 CNN2 ANKS1A KIF16B

3.38e-041020397EFO_0004584
DiseaseNasopharyngeal carcinoma

ERBB3 ARID1A

3.87e-0422392C2931822
Diseasegluteofemoral adipose tissue measurement

EBF1 MAML2 EYA1

7.11e-04132393EFO_0803317
Diseasefacial height measurement

DMRT2 MED13 ANKS1A

8.78e-04142393EFO_0007856
Diseaseserum alanine aminotransferase measurement

PCOLCE2 ERBB3 ATP8B1 EYA1 ARID1A KIF16B

9.12e-04869396EFO_0004735
Diseaseposterior thigh muscle fat infiltration measurement

EBF1 EYA1

9.85e-0435392EFO_0020934
Diseaseprostate cancer (is_marker_for)

NCOA1 NCOA3 ERBB3

1.15e-03156393DOID:10283 (is_marker_for)
Diseaseresponse to risperidone

CNTNAP5 PBX3

1.16e-0338392GO_0097336
Diseasehypospadias

EBF1 EYA1

1.22e-0339392EFO_0004209
Diseaselung non-small cell carcinoma (is_marker_for)

ERBB3 ARID1A FOXA2

1.45e-03169393DOID:3908 (is_marker_for)
Diseasenasopharynx carcinoma (is_marker_for)

ERBB3 ARID1A

1.49e-0343392DOID:9261 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
SSGYMPMNQGNLGES

ERBB3

1051

P21860
QDYLSGMAANMSGTF

ANXA11

51

P50995
DAGMDSNYQTEMGSA

ANKS1A

236

Q92625
SGQEGMQAVMSSDYS

ATP8B1

911

O43520
YGQTGSGKSYTMMGN

KIF16B

101

Q96L93
GTYVCTGSNMFAMDQ

HSPG2

1836

P98160
DGGYSMNFNMSSSRG

RBMX

131

P38159
IHTGMGSYQQNSMGS

ARID1A

781

O14497
FMNMQSLNGDSYQGS

PBX3

351

P40426
MGSLQKGNYSSQSGM

EDRF1

661

Q3B7T1
EMQAPGSGNGDQYSM

EXTL2

196

Q9UBQ6
MAAYGQTQFTTGMQQ

EYA1

106

Q99502
TGGQLMNGSFSMDGT

LHX4

281

Q969G2
MNGSFSMDGTGQSYQ

LHX4

286

Q969G2
AGQSSTMTGTYAGQF

SLC11A1

371

P49279
NKMAGNEYMGFSNAT

GLS2

296

Q9UI32
NTAGNGFMAMFSAAE

PCOLCE2

131

Q9UKZ9
AGGSGQSKVMANYMY

MAML2

501

Q8IZL2
MNSGVAMKYGNDSSA

MCC

1

P23508
MQYSGSGNMELISSN

DMRT2

311

Q9Y5R5
TSMNGYGSAAMSNLG

EBF1

486

Q9UH73
SRSAGMYMQSGSDFN

HOXC10

26

Q9NYD6
MTTSTGNQALYGGQM

KLF18

266

A0A0U1RQI7
TGNQNLYGGQMMTST

KLF18

326

A0A0U1RQI7
LYGGQMMTSTGNQTL

KLF18

331

A0A0U1RQI7
STGNQNLYGGQMMTS

KLF18

381

A0A0U1RQI7
NLYGGQMMTSTGNQT

KLF18

386

A0A0U1RQI7
YGGQMMTSTGNQTLY

KLF18

486

A0A0U1RQI7
TGNQALYGGQMMTST

KLF18

606

A0A0U1RQI7
LYGGQMMTSTGNQAL

KLF18

611

A0A0U1RQI7
TSTGNQALYGGQMMT

KLF18

716

A0A0U1RQI7
QALYGGQMMTSTGNQ

KLF18

721

A0A0U1RQI7
MTTSTGNQALYGGQM

KLF18

756

A0A0U1RQI7
TTSTGNQALYGGQMM

KLF18

841

A0A0U1RQI7
NQALYGGQMMTSTGN

KLF18

846

A0A0U1RQI7
GGQMMTSTGNQNLYG

KLF18

851

A0A0U1RQI7
VSTSMNGYGSGAMAS

EBF3

486

Q9H4W6
ANAMGFAGCMSSVQY

CNTNAP5

1156

Q8WYK1
NTYMSMSAAAMGSGS

FOXA2

41

Q9Y261
GNMSAGSMNMSSYVG

FOXA2

56

Q9Y261
GASNGAYSSQVMQGM

HNRNPF

366

P52597
AYSSQVMQGMGVSAA

HNRNPF

371

P52597
DGGYSMNFNMSSSRG

RBMXL1

131

Q96E39
GSQEGNTMKTNDTYM

TRGC1

56

P0CF51
GSQEGNTMKTNDTYM

TRGC2

56

P03986
SQEGQYYGSSSMGLM

TMEM132D

836

Q14C87
VYNNMSITVSMAGGN

NCOA1

1311

Q15788
MGMGANPYGQAAASN

NCOA3

991

Q9Y6Q9
FGSMNSNAAGSMSTQ

MED13

1561

Q9UHV7
ANLTGGYMVMGDSFN

SEC23B

366

Q15437
DNSSMSLQMGYTQGA

CNN2

241

Q99439
GSQANYGMQQMAGFG

ZCCHC2

1091

Q9C0B9
MNFYGANGMMNYGQS

SMAP2

396

Q8WU79
ANGMMNYGQSMSGGN

SMAP2

401

Q8WU79
AAMAYGMGFATNSMN

SPTLC2

231

O15270
MGMQNVSFFDAESGS

RFPL3

251

O75679
SMSYGMPNQTGSENS

ZMYM4

51

Q5VZL5