Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	dynein intermediate chain binding	TRIM58 DNAH2 DNAH1	1.77e-04	37	59	3	GO:0045505
GeneOntologyCellularComponent	keratohyalin granule	FLG CELA2A	9.76e-05	5	66	2	GO:0036457
GeneOntologyCellularComponent	inner dynein arm	DNAH2 DNAH1	4.35e-04	10	66	2	GO:0036156
GeneOntologyCellularComponent	acrosomal vesicle	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	4.86e-04	206	66	5	GO:0001669
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	5.00e-08	12	61	4	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	5.00e-08	12	61	4	IPR027970
Domain	NPIP	NPIPB15 NPIPB13 NPIPB3 NPIPB5	1.01e-07	14	61	4	IPR009443
Domain	Dynein_heavy_chain_D4_dom	DNAH2 DNAH1	9.31e-04	14	61	2	IPR024317
Domain	Dynein_HC_stalk	DNAH2 DNAH1	9.31e-04	14	61	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH2 DNAH1	9.31e-04	14	61	2	IPR013602
Domain	DHC_N2	DNAH2 DNAH1	9.31e-04	14	61	2	PF08393
Domain	MT	DNAH2 DNAH1	9.31e-04	14	61	2	PF12777
Domain	AAA_8	DNAH2 DNAH1	9.31e-04	14	61	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH2 DNAH1	9.31e-04	14	61	2	IPR011704
Domain	AAA_5	DNAH2 DNAH1	9.31e-04	14	61	2	PF07728
Domain	DHC_fam	DNAH2 DNAH1	1.07e-03	15	61	2	IPR026983
Domain	Dynein_heavy_dom	DNAH2 DNAH1	1.07e-03	15	61	2	IPR004273
Domain	Dynein_heavy	DNAH2 DNAH1	1.07e-03	15	61	2	PF03028
Domain	EGF_Ca-bd_CS	SNED1 FAT3 CUBN	3.93e-03	97	61	3	IPR018097
Domain	EGF_CA	SNED1 FAT3 CUBN	4.16e-03	99	61	3	PS01187
Domain	ASX_HYDROXYL	SNED1 FAT3 CUBN	4.28e-03	100	61	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	SNED1 FAT3 CUBN	5.04e-03	106	61	3	IPR000152
Domain	LAM_G_DOMAIN	FAT3 USH2A	6.84e-03	38	61	2	PS50025
Domain	EGF_CA	SNED1 FAT3 CUBN	7.43e-03	122	61	3	SM00179
Domain	Laminin_G_2	FAT3 USH2A	7.56e-03	40	61	2	PF02210
Domain	EGF-like_Ca-bd_dom	SNED1 FAT3 CUBN	7.77e-03	124	61	3	IPR001881
Domain	LamG	FAT3 USH2A	9.09e-03	44	61	2	SM00282
Domain	EGF_1	SNED1 FAT3 CUBN USH2A	9.64e-03	255	61	4	PS00022
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	1.36e-13	6	67	5	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	1.36e-13	6	67	5	25930072
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A1 SPATA31A3 SPATA31A7 ARMCX4 SPATA31A6 SPATA31A5	5.32e-12	24	67	6	32212159
Pubmed	Hyperglycemia affects neuronal differentiation and Nestin, FOXO1, and LMO3 mRNA expression of human Wharton's jelly mesenchymal stem cells of children from diabetic mothers.	FOXO1 NES	1.10e-05	3	67	2	36413852
Pubmed	Divergent origins and concerted expansion of two segmental duplications on chromosome 16.	NPIPB3 NPIPB5	1.10e-05	3	67	2	11948212
Pubmed	Nestin Mediates Hedgehog Pathway Tumorigenesis.	NES PTCH1	1.10e-05	3	67	2	27496710
Pubmed	A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records.	TRIOBP ILDR1	2.19e-05	4	67	2	27764096
Pubmed	Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing.	FLG CELA2A	3.64e-05	5	67	2	20179351
Pubmed	Vasculature-associated cells expressing nestin in developing bones encompass early cells in the osteoblast and endothelial lineage.	NES PTCH1	3.64e-05	5	67	2	24823376
Pubmed	Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling.	FOXO1 SIN3B	5.46e-05	6	67	2	29056338
Pubmed	Protein phosphatase 4 and Smek complex negatively regulate Par3 and promote neuronal differentiation of neural stem/progenitor cells.	NES PPP4R3A	5.46e-05	6	67	2	24209749
Pubmed	Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.	DNAH2 DNAH1	7.63e-05	7	67	2	9256245
Pubmed	Medulloblastoma Arises from the Persistence of a Rare and Transient Sox2+ Granule Neuron Precursor.	NES PTCH1	1.02e-04	8	67	2	32294450
Pubmed	Proliferation of murine midbrain neural stem cells depends upon an endogenous sonic hedgehog (Shh) source.	NES PTCH1	1.02e-04	8	67	2	23776550
Pubmed	microRNA-205-5p is a modulator of insulin sensitivity that inhibits FOXO function.	FOXO1 SIN3B	1.02e-04	8	67	2	30174230
Pubmed	Smek promotes corticogenesis through regulating Mbd3's stability and Mbd3/NuRD complex recruitment to genes associated with neurogenesis.	NES PPP4R3A	1.30e-04	9	67	2	28467410
Pubmed	The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis.	NES PTCH1	1.30e-04	9	67	2	11748155
Pubmed	Dynein and kinesin regulate stress-granule and P-body dynamics.	DNAH2 DNAH1	1.63e-04	10	67	2	19825938
Pubmed	Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.	NES PTCH1	1.63e-04	10	67	2	22855790
Pubmed	Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway.	ZNF451 PTCH1	2.38e-04	12	67	2	11449277
Pubmed	Smek1/2 is a nuclear chaperone and cofactor for cleaved Wnt receptor Ryk, regulating cortical neurogenesis.	NES PPP4R3A	2.38e-04	12	67	2	29180410
Pubmed	Cytosolic Iron-Sulfur Assembly Is Evolutionarily Tuned by a Cancer-Amplified Ubiquitin Ligase.	TPP1 NSMCE3	2.81e-04	13	67	2	29225034
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH2 DNAH1	3.28e-04	14	67	2	9373155
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	FLG SBF1 NPIPB11 ZNF451 NSMCE3 NME4 PRDM15	3.61e-04	689	67	7	36543142
Pubmed	Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells.	FOXO1 CELA2A	4.31e-04	16	67	2	19635472
Pubmed	Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice.	NES LLGL2	4.31e-04	16	67	2	15037549
Pubmed	Suppressor of fused controls mid-hindbrain patterning and cerebellar morphogenesis via GLI3 repressor.	NES PTCH1	4.88e-04	17	67	2	21289193
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	WDR91 NES SIN3B SF3B1 SBF1 RIPK2 TRIOBP ARMCX4	5.16e-04	963	67	8	28671696
Pubmed	Maternal hyperglycemia activates an ASK1-FoxO3a-caspase 8 pathway that leads to embryonic neural tube defects.	FOXO1 NES	5.48e-04	18	67	2	23982205
Pubmed	alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway.	NES PTCH1	6.12e-04	19	67	2	16543460
Pubmed	Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells.	FOXO1 NES	6.12e-04	19	67	2	16116448
Pubmed	The epigenetic state of EED-Gli3-Gli1 regulatory axis controls embryonic cortical neurogenesis.	NES PTCH1	6.79e-04	20	67	2	35931079
Pubmed	Diencephalic Size Is Restricted by a Novel Interplay Between GCN5 Acetyltransferase Activity and Retinoic Acid Signaling.	NES PTCH1	6.79e-04	20	67	2	28154153
Pubmed	The sequence and analysis of duplication-rich human chromosome 16.	NPIPB11 NPIPB3 NME4	7.12e-04	90	67	3	15616553
Pubmed	Heritability and genetic association analysis of cognition in the Diabetes Heart Study.	FDX1 GLCCI1	7.50e-04	21	67	2	24684796
Pubmed	The DNA Methyltransferase 1 (DNMT1) Controls the Shape and Dynamics of Migrating POA-Derived Interneurons Fated for the Murine Cerebral Cortex.	NES GLCCI1	7.50e-04	21	67	2	29117290
Pubmed	Sertoli Cell Wt1 Regulates Peritubular Myoid Cell and Fetal Leydig Cell Differentiation during Fetal Testis Development.	NES PTCH1	9.01e-04	23	67	2	28036337
Pubmed	Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling.	NES PTCH1	9.01e-04	23	67	2	18728187
Pubmed	The ciliogenic transcription factor RFX3 regulates early midline distribution of guidepost neurons required for corpus callosum development.	NES PTCH1	1.07e-03	25	67	2	22479201
Pubmed	A crucial role for primary cilia in cortical morphogenesis.	NES PTCH1	1.07e-03	25	67	2	19036983
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	SEMA4F SF3B1 STARD9 DNAH2	1.08e-03	233	67	4	37704626
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	FLG NES SF3B1 SBF1 CECR2 TRIOBP COIL NKAPL	1.10e-03	1082	67	8	38697112
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	FOXO1 NES ZNF106 SBF1 STARD9 RIPK2 GLCCI1	1.33e-03	861	67	7	36931259
Pubmed	Primary cilia and Gli3 activity regulate cerebral cortical size.	NES PTCH1	1.44e-03	29	67	2	21976438
Pubmed	Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure.	FOXO1 NES	1.54e-03	30	67	2	22980982
Pubmed	Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex.	SIN3B LRCH4	1.54e-03	30	67	2	16449650
Pubmed	A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.	SNED1 TRIOBP GLCCI1	1.56e-03	118	67	3	30979931
Pubmed	Molecular profiling of the vestibular lamina highlights a key role for Hedgehog signalling.	SNED1 PTCH1	1.64e-03	31	67	2	36971701
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	ZNF106 LLGL2 SF3B1 ZNF451 TRIOBP NSMCE3 COIL GLCCI1	1.66e-03	1155	67	8	20360068
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	ZNF106 SIN3B SF3B1 ZNF451 NSMCE3	1.83e-03	453	67	5	29656893
Pubmed	Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities.	NES PTCH1	1.86e-03	33	67	2	30914320
Pubmed	PAR3 restricts the expansion of neural precursor cells by regulating hedgehog signaling.	NES PTCH1	1.86e-03	33	67	2	36218069
Pubmed	Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex.	FOXO1 SEMA4F PTCH1	1.88e-03	126	67	3	16284245
Cytoband	16p12.2	NPIPB4 NPIPB3 NPIPB5	2.23e-05	37	67	3	16p12.2
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	5.84e-05	8	67	2	chr9q12
Cytoband	9p13.1	SPATA31A1 SPATA31A3	5.67e-04	24	67	2	9p13.1
Cytoband	11p15	TPP1 UBQLN3	1.82e-03	43	67	2	11p15
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	NPIPB4 NPIPB3 NPIPB5	2.08e-03	172	67	3	chr16p12
Cytoband	1q23.1	NES TTC24	2.08e-03	46	67	2	1q23.1
Cytoband	16p11.2	NPIPB13 NPIPB12 NPIPB11	2.79e-03	191	67	3	16p11.2
GeneFamily	Dyneins, axonemal	DNAH2 DNAH1	4.86e-04	17	35	2	536
Coexpression	JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_DN	NPIPB15 SBF1 NPIPB13 NPIPB12 NPIPB11 NPIPB3 ZNF786	8.91e-06	302	64	7	M38975
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNV2 CECR2 FAT3 USH2A UNC80	4.32e-06	160	67	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNV2 CECR2 FAT3 USH2A UNC80	4.32e-06	160	67	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT3 CUBN USH2A UNC80 DNAH1	5.64e-06	169	67	5	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	tumor_Lung-Myeloid_cells-pDCs\|tumor_Lung / Location, Cell class and cell subclass	PALD1 TTC24 FAM221B DIPK2A ANKRD53	7.87e-06	181	67	5	c864ffeb9234b8c29754afc91c85a972889617f4
Disease	Autism Spectrum Disorders	USH2A UNC80 DIPK2A	5.15e-04	85	54	3	C1510586
Disease	mean reticulocyte volume	FOXO1 COMMD1 TRIM58 DNAH2 N4BP2L2 LSM11 PPP4R3A	6.09e-04	799	54	7	EFO_0010701
Disease	hearing impairment	TRIOBP ILDR1 USH2A	7.79e-04	98	54	3	C1384666
Disease	red blood cell density measurement	FOXO1 ZNF106 COMMD1 TRIM58 DNAH2 PPP4R3A PSD4	1.07e-03	880	54	7	EFO_0007978
Disease	pathological myopia	CAPN9 SEMA4F DIPK2A	1.12e-03	111	54	3	EFO_0004207
Disease	eye measurement	FOXO1 SEMA4F	1.12e-03	27	54	2	EFO_0004731

Protein segments in the cluster

Peptide	Gene	Start	Entry
ASHRGGTGTRTWLVD	nan	116	Q8NBF4
SRRTTGQGRKWAAHG	AGPAT4-IT1	61	Q9H0P7
AGRWLHHAGSRAGSS	FDX1	21	P10109
EGAEKRSHQRSASWG	GLCCI1	211	Q86VQ1
DGRWQVHGIVSFGSR	CELA2A	226	P08217
RWSGSASRNHHGSAQ	FLG	636	P20930
SAVRDSGHWGSSGSQ	FLG	1056	P20930
SERWSGSASRNHLGS	FLG	1931	P20930
GSASRNHLGSAWEQS	FLG	1936	P20930
NHLGSAWEQSRDGSR	FLG	1941	P20930
WADSSRHSLVGQGQS	FLG	2216	P20930
ERWSGSASRNHHGSA	FLG	2581	P20930
SHGWTGPSTRGRQGS	FLG	2751	P20930
RWSGSASRNHHGSAQ	FLG	2906	P20930
WSGSASRNHRGSVQE	FLG	3231	P20930
GQASSAVRDSRHWGS	FLG	3321	P20930
AVRDSRHWGSSGSQA	FLG	3326	P20930
DSERWSGSASRNHRG	FLG	3551	P20930
GRSGGSHVWTRSRDP	CECR2	566	Q9BXF3
TGGSWARSEDQASGR	ARMCX4	1706	Q5H9R4
GHDGSTDVQQRAWRS	NPIPB3	96	Q92617
DRQWDDRGTGHVSSG	PPP4R3A	16	Q6IN85
GHDGSTDVQQRAWRS	NPIPB12	96	F8W0I5
SPAQGSGSRHSVWQR	PALD1	406	Q9ULE6
GFHSVDSGSKRWSGN	LRCH4	301	O75427
STARRAGSGSWHSER	ANKRD53	6	Q8N9V6
IRAHGGSGNFSWSSS	NUP210	476	Q8TEM1
LASVWGRADTGRGSH	LSM11	261	P83369
GDRGSGNWRSHRAAV	LLGL2	996	Q6P1M3
HGVSTLGNSSEGRTW	KCNK7	76	Q9Y2U2
AGRGWLQSSDHGQTS	PERP	31	Q96FX8
GGRPRGTDTVSNWHR	FAM221B	386	A6H8Z2
DPSWSGRHRSSRLNG	ILDR1	396	Q86SU0
GLSSQTAGAAGWRRS	COIL	356	P38432
GGLRAQSADTSWRAH	NES	41	P48681
GHDGSTDVQQRAWRS	NPIPB5	96	A8MRT5
GHDGSTDVQQRAWRS	NPIPB4	96	C9JG80
GHDGSTDVQQRAWRS	NPIPB15	96	A6NHN6
HGKWGSVRTSGRSSG	SBF1	1276	O95248
GHDGSTDVQQRAWRS	NPIPB11	96	E5RHQ5
HTLWVRFISDGSGSG	CUBN	1826	O60494
GATGDSSGRTSFSHW	DNAH1	2116	Q9P2D7
GDSNSSAGWKNSIRH	FOXO1	201	Q12778
NLLSRHATWRGTSGG	DIPK2A	366	Q8NDZ4
GISGRAVNDGSWHSV	FAT3	3906	Q8TDW7
SHSRWLRSPQVTGGS	GPR142	51	Q7Z601
GLSWRVDGKSQSRHS	COMMD1	121	Q8N668
VTVHQGSWVRGSTAG	CAPN9	351	O14815
LSGRGSSQASWSGRA	DNAH2	11	Q9P225
GHDGSTDVQQRAWRS	NPIPB13	96	A6NJU9
HGGTNSSAWVEVTTR	USH2A	2706	O75445
WGSQRDAPSRAHTVG	SEMA4F	646	O95754
GGSNSHVSASSRWQE	SPATA31A6	271	Q5VVP1
VRHGSGGPSWTRERT	NME4	26	O00746
SGVEGVWNQHSRSAS	PRDM15	261	P57071
RSGSQASIHGWTEGN	KCNV2	36	Q8TDN2
GGSNSHVSASSRWQE	SPATA31A7	271	Q8IWB4
FSWGASDSHAGVRTG	PSD4	266	Q8NDX1
STEGHSGPSNRARWG	PTCH1	1326	Q13635
LSGARWGRSGSAGHE	SIN3B	21	O75182
GTQTLGSRRHWSSTD	STARD9	3641	Q9P2P6
RSAGQHWARLRGESG	TRIOBP	216	Q9H2D6
RHLERSWSSQEGGLG	TRIOBP	1441	Q9H2D6
TSPRDGADRRWHQGG	SNED1	1196	Q8TER0
SGSIAQHRGSSWGSS	C11orf53	141	Q8IXP5
QHRGSSWGSSLAGAQ	C11orf53	146	Q8IXP5
SWDGCSRSHSRGREG	NKAPL	36	Q5M9Q1
GGSNSHVSASSRWQE	SPATA31A3	271	Q5VYP0
GTKSSFRRGGHTWVS	ZNF451	151	Q9Y4E5
GSSTAGVQHRSSSGW	TTC24	441	A2A3L6
DRGSSWGGSSSAFIH	UNC80	136	Q8N2C7
GGSNSHVSASSRWQE	SPATA31A1	271	Q5TZJ5
GGSNSHVSASSRWQE	SPATA31A5	271	Q5VU36
HGGATSSARKNRWDE	SF3B1	281	O75533
RGASGTVSSARHADW	RIPK2	26	O43353
SGGQAERDRDWSHSG	NSMCE3	11	Q96MG7
IRHSWEGGAIRESSG	nan	686	Q3C1V9
WREGRGASSSVHSGQ	ZNF786	326	Q8N393
SGLATGESGWSQHRQ	WDR91	316	A4D1P6
WTSTHGGSGSRQGRQ	UBQLN3	306	Q9H347
HNGTGRNSSWLSEGT	ZNF106	196	Q9H2Y7
TTIAGSGNWASRDHL	TRIM58	461	Q8NG06
SGAGCWSVSGRHQFR	TPP1	361	O14773
RWGGSLGSHNRVCVT	N4BP2L2	566	Q92802