Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein xylosyltransferase activity

XYLT1 XYLT2

1.11e-052672GO:0030158
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH12 DNAH10 DNAH2

2.84e-0518673GO:0008569
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH12 DNAH10 DNAH2

1.11e-0428673GO:0051959
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH12 DNAH10 DNAH2

2.59e-0437673GO:0045505
GeneOntologyMolecularFunctionUDP-xylosyltransferase activity

XYLT1 XYLT2

5.98e-0411672GO:0035252
GeneOntologyMolecularFunctionxylosyltransferase activity

XYLT1 XYLT2

5.98e-0411672GO:0042285
GeneOntologyCellularComponentinner dynein arm

DNAH12 DNAH10 DNAH2

3.89e-0610683GO:0036156
GeneOntologyCellularComponentaxonemal dynein complex

DNAH12 DNAH10 DNAH2

7.19e-0525683GO:0005858
GeneOntologyCellularComponentmitotic cohesin complex

STAG1 STAG2

2.17e-047682GO:0030892
GeneOntologyCellularComponentcohesin complex

STAG1 STAG2

5.63e-0411682GO:0008278
GeneOntologyCellularComponentdynein complex

DNAH12 DNAH10 DNAH2

7.25e-0454683GO:0030286
DomainATPase_dyneun-rel_AAA

DNAH12 MDN1 DNAH10 DNAH2

1.39e-0714664IPR011704
DomainAAA_5

DNAH12 MDN1 DNAH10 DNAH2

1.39e-0714664PF07728
DomainXylT

XYLT1 XYLT2

1.23e-052662IPR024448
DomainXylo_C

XYLT1 XYLT2

1.23e-052662PF12529
DomainDynein_heavy_chain_D4_dom

DNAH12 DNAH10 DNAH2

1.49e-0514663IPR024317
DomainDynein_heavy_dom-2

DNAH12 DNAH10 DNAH2

1.49e-0514663IPR013602
DomainDHC_N2

DNAH12 DNAH10 DNAH2

1.49e-0514663PF08393
DomainAAA_8

DNAH12 DNAH10 DNAH2

1.49e-0514663PF12780
DomainDHC_fam

DNAH12 DNAH10 DNAH2

1.86e-0515663IPR026983
DomainDynein_heavy_dom

DNAH12 DNAH10 DNAH2

1.86e-0515663IPR004273
DomainDynein_heavy

DNAH12 DNAH10 DNAH2

1.86e-0515663PF03028
DomainSTAG

STAG1 STAG2

7.35e-054662IPR013721
DomainSCD

STAG1 STAG2

7.35e-054662PS51425
DomainSCD

STAG1 STAG2

7.35e-054662IPR020839
DomainSTAG

STAG1 STAG2

7.35e-054662PF08514
DomainAAA+_ATPase

DNAH12 MDN1 DNAH10 CFTR DNAH2

1.56e-04144665IPR003593
DomainAAA

DNAH12 MDN1 DNAH10 CFTR DNAH2

1.56e-04144665SM00382
DomainMob1_phocein

MOB3C MOB3A

2.55e-047662PF03637
DomainMOB_kinase_act_fam

MOB3C MOB3A

2.55e-047662IPR005301
Domain-

MOB3C MOB3A

2.55e-0476621.20.140.30
DomainMob1_phocein

MOB3C MOB3A

2.55e-047662SM01388
DomainGlyco_trans_14

XYLT1 XYLT2

3.40e-048662IPR003406
DomainDHC_N1

DNAH10 DNAH2

3.40e-048662PF08385
DomainBranch

XYLT1 XYLT2

3.40e-048662PF02485
DomainDynein_heavy_dom-1

DNAH10 DNAH2

3.40e-048662IPR013594
DomainDynein_HC_stalk

DNAH10 DNAH2

1.09e-0314662IPR024743
DomainMT

DNAH10 DNAH2

1.09e-0314662PF12777
DomainFerritin-like_SF

MOB3C MOB3A

1.09e-0314662IPR009078
DomainARM-type_fold

FOCAD DOCK2 STAG1 RANBP6 HUWE1 STAG2

1.24e-03339666IPR016024
DomainARM-like

DOCK2 STAG1 RANBP6 HUWE1 STAG2

2.65e-03270665IPR011989
Domain-

TBC1D10B PDE9A

2.71e-03226621.10.1300.10
DomainPDEase_catalytic_dom

TBC1D10B PDE9A

2.97e-0323662IPR002073
Domain-

DNAH12 MDN1 DHX58 DNAH10 CFTR YLPM1 DNAH2 NOD2

4.63e-037466683.40.50.300
DomainP-loop_NTPase

DNAH12 MDN1 DHX58 DNAH10 CFTR YLPM1 DNAH2 NOD2

9.78e-03848668IPR027417
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH12 DNAH10 DNAH2

1.09e-0427493M47755
PathwayKEGG_MEDICUS_REFERENCE_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_LINKAGE_TETRASACCHARIDE

XYLT1 XYLT2

1.18e-045492M47914
PathwayKEGG_MEDICUS_REFERENCE_ESTABLISHMENT_OF_COHESION

STAG1 STAG2

2.46e-047492M47869
PathwayREACTOME_NEF_AND_SIGNAL_TRANSDUCTION

DOCK2 HCK

3.27e-048492M26997
PathwayKEGG_MEDICUS_REFERENCE_COHESIN_LOADING

STAG1 STAG2

4.20e-049492M47868
PathwayKEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT

DNAH12 DNAH10 DNAH2

4.42e-0443493M47669
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH12 DNAH10 DNAH2

5.05e-0445493M47670
PathwayREACTOME_COHESIN_LOADING_ONTO_CHROMATIN

STAG1 STAG2

5.23e-0410492M27178
PathwayREACTOME_COHESIN_LOADING_ONTO_CHROMATIN

STAG1 STAG2

5.23e-0410492MM14892
PathwayREACTOME_ESTABLISHMENT_OF_SISTER_CHROMATID_COHESION

STAG1 STAG2

6.38e-0411492M27177
PathwayREACTOME_ESTABLISHMENT_OF_SISTER_CHROMATID_COHESION

STAG1 STAG2

6.38e-0411492MM14891
PathwayREACTOME_MITOTIC_TELOPHASE_CYTOKINESIS

STAG1 STAG2

9.01e-0413492M27661
PathwayREACTOME_MITOTIC_TELOPHASE_CYTOKINESIS

STAG1 STAG2

9.01e-0413492MM15363
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

FOCAD HAUS4 MDN1 NF2 SZT2 PCNX4 PITX1 FLCN HUWE1 GBA2 MPRIP ITPR3 NOD2

2.33e-071105691335748872
Pubmed

The functional interactome landscape of the human histone deacetylase family.

ZNF609 MDN1 STAG1 YLPM1 HUWE1 STAG2 ZMYM3

1.77e-0628969723752268
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH12 DNAH10 DNAH2

2.68e-06146939373155
Pubmed

STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells.

STAG1 STAG2

3.88e-06269234648034
Pubmed

STAG Mutations in Cancer.

STAG1 STAG2

3.88e-06269231421907
Pubmed

Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis.

IRF4 NOD2

3.88e-06269218188453
Pubmed

Xylosyltransferase-deficient human HEK293 cells show a strongly reduced proliferation capacity and viability.

XYLT1 XYLT2

3.88e-06269231677793
Pubmed

Distinct and overlapping roles of STAG1 and STAG2 in cohesin localization and gene expression in embryonic stem cells.

STAG1 STAG2

3.88e-06269232778134
Pubmed

Serum xylosyltransferase: a new biochemical marker of the sclerotic process in systemic sclerosis.

XYLT1 XYLT2

3.88e-06269210383739
Pubmed

Expression of xylosyltransferases I and II and their role in the pathogenesis of arthrofibrosis.

XYLT1 XYLT2

3.88e-06269231973761
Pubmed

High xylosyltransferase activity in children and during mineralization of osteoblast-like SAOS-2 cells.

XYLT1 XYLT2

3.88e-06269218763033
Pubmed

Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II.

XYLT1 XYLT2

3.88e-06269211099377
Pubmed

Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer.

STAG1 STAG2

3.88e-06269229649003
Pubmed

Nuclear import and export signals of human cohesins SA1/STAG1 and SA2/STAG2 expressed in Saccharomyces cerevisiae.

STAG1 STAG2

3.88e-06269222715410
Pubmed

Synthetic lethal interaction between the tumour suppressor STAG2 and its paralog STAG1.

STAG1 STAG2

3.88e-06269228430577
Pubmed

Xylosyltransferase gene variants and their role in essential hypertension.

XYLT1 XYLT2

3.88e-06269219197251
Pubmed

Cohesin subunits, STAG1 and STAG2, and cohesin regulatory factor, PDS5b, in oral squamous cells carcinomas.

STAG1 STAG2

3.88e-06269227341316
Pubmed

Cloning and recombinant expression of active full-length xylosyltransferase I (XT-I) and characterization of subcellular localization of XT-I and XT-II.

XYLT1 XYLT2

3.88e-06269216569644
Pubmed

Xylosyltransferase 2 deficiency and organ homeostasis.

XYLT1 XYLT2

3.88e-06269232965647
Pubmed

Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts.

STAG1 STAG2

3.88e-06269228691904
Pubmed

Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres.

STAG1 STAG2

3.88e-06269222415365
Pubmed

Distinct functions of human cohesin-SA1 and cohesin-SA2 in double-strand break repair.

STAG1 STAG2

3.88e-06269224324008
Pubmed

A conserved sequence in the T-cell receptor beta-chain promoter region.

TRBV12-4 TRBV12-3

3.88e-0626923259318
Pubmed

Development of a xylosyltransferase-I-selective UPLC MS/MS activity assay using a specific acceptor peptide.

XYLT1 XYLT2

3.88e-06269233609631
Pubmed

The T cell receptor from an influenza-A specific murine CTL clone.

TRBV12-4 TRBV12-3

3.88e-0626922784852
Pubmed

Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells.

STAG1 STAG2

3.88e-06269219822671
Pubmed

Human xylosyltransferase II is involved in the biosynthesis of the uniform tetrasaccharide linkage region in chondroitin sulfate and heparan sulfate proteoglycans.

XYLT1 XYLT2

3.88e-06269217189265
Pubmed

Biosynthesis of chondroitin and heparan sulfate in chinese hamster ovary cells depends on xylosyltransferase II.

XYLT1 XYLT2

3.88e-06269217189266
Pubmed

STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.

STAG1 STAG2

3.88e-06269232467316
Pubmed

Specialized functions of cohesins STAG1 and STAG2 in 3D genome architecture.

STAG1 STAG2

3.88e-06269232294612
Pubmed

Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation.

STAG1 STAG2

3.88e-06269231495782
Pubmed

Xylosyltransferase II is a significant contributor of circulating xylosyltransferase levels and platelets constitute an important source of xylosyltransferase in serum.

XYLT1 XYLT2

3.88e-06269219389916
Pubmed

The xylosyltransferase Iota gene polymorphism c.343G>T (p.A115S) is associated with decreased serum glycosaminoglycan levels.

XYLT1 XYLT2

3.88e-06269219014925
Pubmed

The xylosyltransferase I gene polymorphism c.343G>T (p.A125S) is a risk factor for diabetic nephropathy in type 1 diabetes.

XYLT1 XYLT2

3.88e-06269217003309
Pubmed

Xylosyltransferase activity in seminal plasma of infertile men.

XYLT1 XYLT2

3.88e-06269211814476
Pubmed

Impact of polymorphisms in the genes encoding xylosyltransferase I and a homologue in type 1 diabetic patients with and without nephropathy.

XYLT1 XYLT2

3.88e-06269216164625
Pubmed

Interaction between superantigen and T-cell receptor Vbeta element determines levels of superantigen-dependent cell-mediated cytotoxicity of CD8(+) T cells in induction and effector phases.

TRBV12-4 TRBV12-3

3.88e-06269219659929
Pubmed

First isolation of human UDP-D-xylose: proteoglycan core protein beta-D-xylosyltransferase secreted from cultured JAR choriocarcinoma cells.

XYLT1 XYLT2

3.88e-06269211087729
Pubmed

Single-molecule imaging reveals a direct role of CTCF's zinc fingers in SA interaction and cluster-dependent RNA recruitment.

STAG1 STAG2

1.16e-05369238742641
Pubmed

Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications.

STAG1 STAG2

1.16e-05369224335498
Pubmed

Analysis of the T cell receptor (TcR) regions in the NOD, NON and CTS mouse strains define new TcR V alpha haplotypes and new deletions in the TcR V beta region.

TRBV12-4 TRBV12-3

1.16e-0536921532150
Pubmed

A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease.

SLC22A5 NOD2

1.16e-05369215685536
Pubmed

Functional variants of OCTN cation transporter genes are associated with Crohn disease.

SLC22A5 NOD2

1.16e-05369215107849
Pubmed

Contribution of OCTN variants within the IBD5 locus to pediatric onset Crohn's disease.

SLC22A5 NOD2

1.16e-05369216771961
Pubmed

Evidence for common genetic control in pathways of inflammation for Crohn's disease and psoriatic arthritis.

SLC22A5 NOD2

1.16e-05369216255050
Pubmed

Pseudoxanthoma Elasticum

XYLT1 XYLT2

1.16e-05369220301292
Pubmed

Characterization of the interaction between the cohesin subunits Rad21 and SA1/2.

STAG1 STAG2

1.16e-05369223874961
Pubmed

Variants of OCTN1-2 cation transporter genes are associated with both Crohn's disease and ulcerative colitis.

SLC22A5 NOD2

1.16e-05369216441470
Pubmed

The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn's disease.

SLC22A5 NOD2

1.16e-05369216344054
Pubmed

OCTN and CARD15 gene polymorphism in Chinese patients with inflammatory bowel disease.

SLC22A5 NOD2

1.16e-05369218756601
Pubmed

Molecular modeling in the age of clinical genomics, the enterprise of the next generation.

CFTR NOD2

1.16e-05369228204942
Pubmed

Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2.

STAG1 STAG2

1.16e-05369236898992
Pubmed

T cell receptor genes in an alloreactive CTL clone: implications for rearrangement and germline diversity of variable gene segments.

TRBV12-4 TRBV12-3

1.16e-0536923490968
Pubmed

Prevalence of SLC22A4, SLC22A5 and CARD15 gene mutations in Hungarian pediatric patients with Crohn's disease.

SLC22A5 NOD2

1.16e-05369217006998
Pubmed

Role of CARD15, DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases.

SLC22A5 NOD2

2.32e-05469217451203
Pubmed

Risk factors for perianal Crohn's disease: the role of genotype, phenotype, and ethnicity.

SLC22A5 NOD2

2.32e-05469217509030
Pubmed

rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.

SLC22A5 NOD2

2.32e-05469217786191
Pubmed

Tandem linkage and unusual RNA splicing of the T-cell receptor beta-chain variable-region genes.

TRBV12-4 TRBV12-3

2.32e-0546923470773
Pubmed

Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population.

HUWE1 SLC1A3

2.32e-05469233581058
Pubmed

NOD2 ligation subverts IFN-alpha production by liver plasmacytoid dendritic cells and inhibits their T cell allostimulatory activity via B7-H1 up-regulation.

IRF4 NOD2

2.32e-05469219890047
Pubmed

Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease.

SLC22A5 NOD2

2.32e-05469216437728
Pubmed

SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs.

STAG1 STAG2

2.32e-0546929305759
Pubmed

B Cell Defects Observed in Nod2 Knockout Mice Are a Consequence of a Dock2 Mutation Frequently Found in Inbred Strains.

DOCK2 NOD2

2.32e-05469230012848
Pubmed

Association of organic cation transporter risk haplotype with perianal penetrating Crohn's disease but not with susceptibility to IBD.

SLC22A5 NOD2

2.32e-05469216344053
Pubmed

Return to quiescence of mouse neural stem cells by degradation of a proactivation protein.

HUWE1 SLC1A3

2.32e-05469227418510
Pubmed

Relationship between CARD15, SLC22A4/5, and DLG5 polymorphisms and early-onset inflammatory bowel diseases: an Italian multicentric study.

SLC22A5 NOD2

2.32e-05469216670523
Pubmed

Murine T-cell receptor mutants with deletions of beta-chain variable region genes.

TRBV12-4 TRBV12-3

2.32e-0546923456168
Pubmed

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.

IARS2 MDN1 SZT2 ANGEL1 RANBP6 KEAP1 HUWE1 SLC1A3

2.67e-0560669836538041
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

DNAH12 MDN1 DNAH2 FLCN OR2T1 SLC1A3 STAG2 ITPR3

3.84e-0563869831182584
Pubmed

Genetic susceptibility has a more important role in pediatric-onset Crohn's disease than in adult-onset Crohn's disease.

SLC22A5 NOD2

3.86e-05569217476680
Pubmed

STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis.

STAG1 STAG2

3.86e-05569212034751
Pubmed

The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population.

SLC22A5 NOD2

3.86e-05569218162085
Pubmed

NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6.

IRF4 NOD2

3.86e-05569224670424
Pubmed

Identification and characterization of SA/Scc3p subunits in the Xenopus and human cohesin complexes.

STAG1 STAG2

3.86e-05569210931856
Pubmed

Essential Roles of Cohesin STAG2 in Mouse Embryonic Development and Adult Tissue Homeostasis.

STAG1 STAG2

3.86e-05569232783938
Pubmed

Germline organization of the murine T cell receptor beta-chain genes.

TRBV12-4 TRBV12-3

3.86e-0556922821625
Pubmed

Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4.

IRF4 NOD2

3.86e-05569228434881
Pubmed

Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult- and pediatric-onset inflammatory bowel disease in Italy.

SLC22A5 NOD2

3.86e-05569218698678
Pubmed

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

DOCK2 ANGPT1 DNAH10 SLC22A5 MPRIP

4.87e-0519969523382691
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

ZNF609 MDN1 HUWE1 ZMYM3

5.62e-051046949205841
Pubmed

Lack of evidence for association of primary sclerosing cholangitis and primary biliary cirrhosis with risk alleles for Crohn's disease in Polish patients.

SLC22A5 NOD2

5.79e-05669218715515
Pubmed

Inflammatory response gene polymorphisms and their relationship with colorectal cancer risk.

SLC22A5 NOD2

5.79e-05669218433468
Pubmed

Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2.

STAG1 STAG2

5.79e-05669215737063
Pubmed

Protein requirements for sister telomere association in human cells.

STAG1 STAG2

5.79e-05669217962804
Pubmed

Cryo-EM structure of the human cohesin-NIPBL-DNA complex.

STAG1 STAG2

5.79e-05669232409525
Pubmed

Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.

DNAH12 DNAH2

8.09e-0576929256245
Pubmed

Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts.

STAG1 STAG2

8.09e-05769215855230
Pubmed

Genetic polymorphisms associated with inflammatory bowel disease do not confer risk for primary sclerosing cholangitis.

SLC22A5 NOD2

8.09e-05769217100974
Pubmed

HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.

STAG1 STAG2

8.09e-05769222885700
Pubmed

Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability.

ZNF609 DNAH10 KLHL42 SLC1A3

1.04e-0412269431615875
Pubmed

Molecular characterization of human homologs of yeast MOB1.

MOB3C MOB3A

1.08e-04869219739119
Pubmed

Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization.

STAG1 STAG2

1.08e-04869229867216
Pubmed

A potential role for human cohesin in mitotic spindle aster assembly.

STAG1 STAG2

1.08e-04869211590136
Pubmed

Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.

STAG1 STAG2

1.38e-04969217349791
Pubmed

Differential transcriptional regulation of individual TCR V beta segments before gene rearrangement.

TRBV12-4 TRBV12-3

1.38e-04969211160223
Pubmed

Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression.

STAG1 STAG2

1.38e-04969216682347
Pubmed

Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase.

STAG1 STAG2

1.38e-04969217112726
Pubmed

RAD21L, a novel cohesin subunit implicated in linking homologous chromosomes in mammalian meiosis.

STAG1 STAG2

1.73e-041069221242291
Pubmed

NEDD4L-mediated Merlin ubiquitination facilitates Hippo pathway activation.

NF2 HUWE1

1.73e-041069233058421
Pubmed

Structural basis and regulation of the reductive stress response.

BEX1 FLCN

1.73e-041069234562363
InteractionKRT34 interactions

DOCK2 PDE9A BEX1 CFTR SLC22A5 PITX1 RAB3IL1 HCK

4.88e-06283688int:KRT34
GeneFamilyDyneins, axonemal

DNAH12 DNAH10 DNAH2

1.16e-0517483536
GeneFamilyMOB kinase activators|STRIPAK complex

MOB3C MOB3A

1.44e-047482647
GeneFamilyCohesin complex

STAG1 STAG2

1.91e-0484821060
GeneFamilyGlucosaminyl (N-acetyl) transferases/xylosyltransferases

XYLT1 XYLT2

1.91e-048482441
GeneFamilyKelch like|BTB domain containing

KLHL42 KEAP1

5.55e-0342482617
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANGPT1 DPY19L2 MAP4K3 PCNX4 LRRN2

3.39e-0615068587968ce885a4959616f0321f58517fe8029ba1b1
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK2 DHX58 DNAH10 SLC1A3 ADCY3

5.09e-061636858dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK2 DHX58 DNAH10 SLC1A3 ADCY3

5.09e-06163685fd243ca223079033be480a24817a399f281fa4d4
ToppCellControl-Myeloid-Dendritic_cells|Control / group, cell type (main and fine annotations)

DOCK2 XYLT1 LRRC8C SLC1A3 HCK

8.24e-0618068525ad95c3c30e3b82abe93bd77ba003f5c2241f7c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANGPT1 DPY19L2 MAP4K3 LRRN2 OPHN1

9.66e-06186685d65fa6d8e8a195ea10cfde1499d096d6acf7a634
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANGPT1 DPY19L2 MAP4K3 LRRN2 OPHN1

9.66e-0618668508632045d499e61dd96ff29a5a9a208afe58dc58
ToppCellFetal_29-31_weeks-Immune-monocyte-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DOCK2 XYLT1 IRF4 HCK NOD2

1.07e-05190685ad297172a74a80ed5c10f921e15efd1da0fd2d6b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 RGL1 TMC8 SLC1A3 HCK

1.13e-0519268586d792682ba51696f503c79625dd20f87bcf651f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 RGL1 TMC8 SLC1A3 HCK

1.13e-05192685d0ad6a205ad50a3c523fa68676996b289eabc5de
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 RGL1 TMC8 SLC1A3 HCK

1.15e-05193685bd08555f02db8bc903caacae57e80bb91e2556ce
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 RGL1 TMC8 SLC1A3 HCK

1.15e-05193685f597fefc54327a1ad136e2f66b6e81cc5c761eb7
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 RGL1 TMC8 SLC1A3 HCK

1.15e-05193685374d0526a071e973c3f43b4564f78f6933bb67ed
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 RGL1 TMC8 SLC1A3 HCK

1.21e-0519568591a3c439f10c03c5d51d904f512b6a08040edc76
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 TMC8 IRF4 SLC1A3 HCK

1.21e-051956852d485373bfd9bb4bb9236bf0b31d03e132c8018f
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 TMC8 IRF4 SLC1A3 HCK

1.21e-05195685ce8215d503cad3a9bc7d5d2be4adb57408015593
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 RGL1 SLC1A3 HCK NOD2

1.27e-051976858af4a1e35ce9fb4ea3d26ab619599efb7eac43a5
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK2 RGL1 RAB3IL1 SLC1A3 HCK

1.31e-05198685c7dbf24caae5c4ef285845d13055de9e07281bb3
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

FOCAD ZNF609 STAG1 MAP4K3 OPHN1

1.34e-0519968594b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellParenchymal-NucSeq-Immune_Myeloid-Dendritic_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK2 XYLT1 IRF4 HCK NOD2

1.37e-05200685f19b729b03b5f225b9ed676f0ac31071a4354da3
ToppCellBronchial-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD14|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK2 XYLT1 MOB3A HCK NOD2

1.37e-052006855432bdf495431cd26f6e4cd585100f3652588913
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ANGPT1 DPY19L2 MAP4K3 LRRN2

1.10e-0416268436ddebe3bb172c992739353b7b049b2dde98b559
ToppCell10x5'-GI_large-bowel-Lymphocytic_T_CD4-Tfh|GI_large-bowel / Manually curated celltypes from each tissue

TRBV12-4 PDE9A SERINC1 TMC8

1.13e-041636844104d3b9748b39cb0744c9be76db21bdda566a0d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DPY19L2 MAP4K3 PCNX4 CFTR

1.18e-041656849bd332e5ede759a00a47728ea5558c215efdd77a
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC1-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SYT15B IRF4 SERPINF2 ZNF891

1.21e-04166684c8a7d94ed762e5e045ab5f74eef691ddc5f74993
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

DNAH2 TMC8 IRF4 ITPR3

1.24e-04167684063ec29b32e40aaa138a691da3a79ee8eef0c2be
ToppCellLPS-IL1RA-Lymphocytic_NKT-T_cells-T-cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK2 TBC1D10B TMC8 IRF4

1.36e-04171684539ea88acc6f948efdeae8b69e5c5ffaee29f1d9
ToppCellcontrol-Myeloid-Monocyte-derived_Macrophage|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DOCK2 LRRC8C IRF4 HCK

1.36e-04171684e828b684744a4fdf6b63ec033c4f000b39ca0d51
ToppCellLPS-IL1RA-Lymphocytic_NKT-T_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK2 TBC1D10B TMC8 IRF4

1.39e-041726840fc692be845d4225ff8b63bf9195724fc8510c2c
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

FOCAD ANGEL1 ADCY3 NOD2

1.39e-04172684da959c1abadafd79b7a0088a25eb8ef8efa3a0c2
ToppCell367C-Myeloid-Dendritic-cDC_activated|367C / Donor, Lineage, Cell class and subclass (all cells)

DHX58 IRF4 SERPINF2 HCK

1.42e-0417368494f99f7e7813d6e53e0bedf97087400b1bf00129
ToppCellNS-control-d_0-4-Myeloid-Monocyte-derived_Macrophage|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DOCK2 LRRC8C IRF4 HCK

1.45e-04174684758984730cd1c3ccf6866a3a8f03d6e002f3edb6
ToppCellnormal_Lymph_Node-Myeloid_cells-pDCs|Myeloid_cells / Location, Cell class and cell subclass

DNAH10 IRF4 ZNF891 OPHN1

1.45e-041746842274648b80dd74f3c948a779bba3391095964c34
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DPY19L2 MAP4K3 PCNX4 CFTR

1.48e-0417568477c16e615c0fb9c83f29d7e0a547be72635fac81
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DPY19L2 PCNX4 CFTR UNC80

1.48e-0417568498947a226b5a2ac7091ff9d34243ea7736add973
ToppCellnormal_Lymph_Node-Myeloid_cells-pDCs|normal_Lymph_Node / Location, Cell class and cell subclass

DNAH10 IRF4 ZNF891 OPHN1

1.52e-04176684476794ef75ce5ab732d78cfeb4944e2f841e3e92
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DPY19L2 PCNX4 CFTR LRRN2

1.52e-04176684c2c4306476989bc2fb30dab00250ef7915842f13
ToppCellLPS-antiTNF-Lymphocytic_NKT-T_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK2 TBC1D10B TMC8 IRF4

1.52e-04176684ea27e18407b8a13e8212830da859efeb8f158690
ToppCellLPS-antiTNF-Lymphocytic_NKT-T_cells-T-cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK2 TBC1D10B TMC8 IRF4

1.52e-04176684bfbab3c5b738b3b0b1540f2059d0245fbd8c0031
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 RGL1 SLC1A3 HCK

1.58e-0417868424e8c62060455159235985f456af0c5023a7f3f5
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 RGL1 SLC1A3 HCK

1.58e-041786844f1cc954d4d9b5b2b75a4cf995ba81e2ada27084
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DPY19L2 PCNX4 SLC22A5 SERPINF2

1.62e-0417968427ad6a609fe1f7532b142d0147bccf918704a6dd
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Non-classical_Monocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 XYLT1 TMC8 HCK

1.69e-041816848657d35cd3dff6c89d0fde67d7e7e81e1d6c8884
ToppCellCOVID-19-kidney-Mito-rich_(Imm)|kidney / Disease (COVID-19 only), tissue and cell type

DOCK2 TMC8 IRF4 NOD2

1.69e-041816848448c2ad560cfd48bfe9dc1dd3a64373e6a622dd
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANGPT1 DPY19L2 MAP4K3 OPHN1

1.76e-041836842f0ee40e69ad1259e56e8ee4b352736900eb8901
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANGPT1 DPY19L2 MAP4K3 OPHN1

1.76e-041836842e831a4d99c6f983793df71c0994124c943c6da9
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

DNAH12 DPY19L2 DNAH10 DNAH2

1.80e-041846845daff849625f2f41d56615569c0ed59cd733b34c
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_2|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

FOCAD DHX58 MAP4K3 KLHL42

1.83e-04185684e06a784a297f357f3f8e761c24fa70722048ab42
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D175|Adult / Lineage, Cell type, age group and donor

DOCK2 RGL1 RAB3IL1 HCK

1.83e-04185684ab5704b96f1d368911308797d10c7c52766ab134
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 TMC8 SLC1A3 HCK

1.87e-04186684e152bdd837366e3e0b8bcfdb4d53f0685f2e803a
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Endothelial_Myeloid|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK2 TMC8 SLC1A3 HCK

1.91e-041876845ce7cf02990465b6f793205e4be07e8337b3570a
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia-Micro_L1-6_C1QC|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK2 TMC8 SLC1A3 HCK

1.91e-0418768417a37fc3a1d62fef3137e5ff26a84c0b8c80e124
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Endothelial_Myeloid-Micro|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK2 TMC8 SLC1A3 HCK

1.91e-041876841b0eb29394040555516677b9de75c15e769c4c53
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK2 TMC8 SLC1A3 HCK

1.91e-0418768411c773cf3dc1e725b7e4d8edd676c8a94a231d2a
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK2 TMC8 SLC1A3 HCK

1.95e-041886845df5a0890e17d19f55770525345a656253696887
ToppCellhuman_hepatoblastoma-NK.T_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

DOCK2 XYLT1 TMC8 IRF4

1.95e-0418868471b7599e7e1d63cc0c8518c0501533755951d58f
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia-Micro_L1-6_C1QC|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK2 TMC8 SLC1A3 HCK

1.95e-041886849e923b0d79495ee1a3a097741a877f25d439eda3
ToppCellAdult-Epithelial-ciliated_cell-D231|Adult / Lineage, Cell type, age group and donor

DNAH12 DPY19L2 DNAH10 DNAH2

1.95e-0418868434b11f72ca73153d02edcd09b38983ad1a504659
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Endothelial_Myeloid-Micro|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK2 TMC8 SLC1A3 HCK

1.95e-0418868414dbc985abc2012c9f53deb243d465e4175f419f
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 TMC8 SLC1A3 HCK

1.95e-041886840d7296ad26e97ad91c6927a6cfe4e6e70a74c5a6
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia-Micro_L1-6_C1QC|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK2 TMC8 SLC1A3 HCK

1.99e-04189684389ccb68acb82893709f256315111470cf4beed3
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ANGPT1 DPY19L2 MAP4K3 LRRN2

1.99e-0418968490aae7e806882bebfad78a78e9a16cf56af3ecd4
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK2 TMC8 SLC1A3 HCK

1.99e-0418968458465b9407fbce91cca8f199950d6e0054c38fbc
ToppCellCOVID-19-Heart-Macrophage|COVID-19 / Disease (COVID-19 only), tissue and cell type

DOCK2 RGL1 SLC1A3 HCK

1.99e-041896842586f4088721c5debec86c2b211b739fd33713eb
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Endothelial_Myeloid-Micro|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK2 TMC8 SLC1A3 HCK

1.99e-041896847ac78441a15a82218deaafd47accff2ea5c8de20
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 RGL1 SLC1A3 HCK

2.03e-04190684788ff9d8888d2dd25b7e1d7e0e5d57751ce86f19
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 TMC8 SLC1A3 HCK

2.03e-041906847c402aa47f1bd7decacc366c1ed1a37e39b95c73
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Endothelial_Myeloid|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK2 TMC8 SLC1A3 HCK

2.03e-04190684d4f954e0748898df69e1710df558564db703dd61
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 TMC8 SLC1A3 HCK

2.07e-0419168451f5af610983aa73b9f4ece6f27d281ebff89a04
ToppCellhuman_hepatoblastoma-Inflammatory_Monocytes|World / Sample and Cell Type and Tumor Cluster (all cells)

DOCK2 XYLT1 SLC1A3 HCK

2.07e-041916843b59bfc6c106ae8a3fbcd4a74bd128c485724921
ToppCellAdult-Immune-monocyte-D175|Adult / Lineage, Cell type, age group and donor

DOCK2 XYLT1 HCK NOD2

2.07e-04191684cbebb4d9550fdcd606cb3685ac9546c6b73fd422
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 TMC8 SLC1A3 HCK

2.07e-04191684c72e62cf5b45c04ee5e7719db31f917c4f76b1e4
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 TMC8 SLC1A3 HCK

2.07e-041916848fd6bdc9d2b1c8d364221d7bc68d03921b668ab5
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 SLC1A3 HCK NOD2

2.16e-041936843e3d7cb3e7242ec9c9677e07e303835649852b52
ToppCellChildren_(3_yrs)-Immune-monocyte-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

DOCK2 XYLT1 HCK NOD2

2.16e-0419368458e1930a1d80ad3729ab9604ac8ebf7308232a3d
ToppCellControl-Myeloid-Monocyte-derived_macrophages|Control / group, cell type (main and fine annotations)

DOCK2 RGL1 SLC1A3 HCK

2.16e-04193684a6b3bd01e585e2e3fbe9bf693a2e385773123f8e
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)|Adult / Lineage, Cell type, age group and donor

DOCK2 RGL1 RAB3IL1 SLC1A3

2.16e-0419368431c0978ba78c9516d498aec0798902e57555e557
ToppCellImmune-interstitial_macrophage_(C1Q_positive)|World / Lineage, Cell type, age group and donor

DOCK2 RGL1 SLC1A3 HCK

2.16e-0419368464d598162a256ac6c9f8280c8a9133661dfbb10f
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 TMC8 SLC1A3 HCK

2.20e-0419468496f16bcd393a0d3f8df479b172b5360ae5a1e663
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 TMC8 SLC1A3 HCK

2.20e-041946840866ab6792cee274a71991d5c37a37f574ff446e
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

DOCK2 RGL1 SLC1A3 HCK

2.20e-04194684663e7e7fe48157e808b4f1a0ea6ad41944e857a2
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 RGL1 SLC1A3 HCK

2.20e-041946841dce6d4b6ac41f80677e3e4c335a4f383bd76f85
ToppCellhuman_hepatoblastoma-NK.T_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

DOCK2 XYLT1 TMC8 IRF4

2.20e-04194684997b02a22d7c89a8fd5615bb79a2a8a34fc3fee6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 RGL1 SLC1A3 HCK

2.20e-04194684c95d5c4ad0210ebd672926558cc8331e6396a854
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Non-classical_Monocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 XYLT1 SLC1A3 HCK

2.24e-041956841d58585557bf8e9ce4d514e128d3a902b526331d
ToppCellCOVID-19-Myeloid-Monocyte-derived_macrophages|COVID-19 / group, cell type (main and fine annotations)

DOCK2 RGL1 SLC1A3 HCK

2.24e-04195684c172c5599379c29123340621a36bfb1fc90c2115
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|lung / Disease (COVID-19 only), tissue and cell type

DOCK2 RGL1 SLC1A3 HCK

2.24e-04195684148fff8c3c9ba45ec36e98dff1be57e3f8294506
ToppCellChildren_(3_yrs)-Immune-monocyte-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DOCK2 XYLT1 SLC1A3 HCK

2.24e-0419568481a28289eda1a8a1a31b7357106f64ac5000e172
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 XYLT1 HCK NOD2

2.24e-0419568462dc745e1aa3e2e58afa16c7bb2cf9b03d4e8105
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Non-classical_Monocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 XYLT1 HCK NOD2

2.24e-0419568410ce1b6961f10372d1f65388cbf3626a5fcd6840
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 RGL1 SLC1A3 HCK

2.24e-04195684247803cf58c6d9c561a52aa34e581188ddad197e
ToppCellLA-08._Macrophage|LA / Chamber and Cluster_Paper

DOCK2 RGL1 SLC1A3 HCK

2.24e-041956845e1d5bdb8874091f5a2b1d0a8cc9008165718a97
ToppCellhuman_hepatoblastoma-Inflammatory_Monocytes|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

DOCK2 XYLT1 SLC1A3 HCK

2.24e-04195684ba7f85e5307d96ac5ad7c952f8d094db9ca1790c
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANGPT1 DPY19L2 MAP4K3 LRRN2

2.24e-041956843f517c6fc372bdcaf45b3af373414f13cbebd4ba
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 TMC8 SLC1A3 HCK

2.24e-041956847b6c69df943842b566a596e30bb50dbe80dccc83
ToppCellBronchial-NucSeq|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations

ZNF609 STAG1 MAP4K3 OPHN1

2.29e-04196684ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCellAdult-Immune-monocyte-D122|Adult / Lineage, Cell type, age group and donor

DOCK2 XYLT1 SLC1A3 HCK

2.29e-0419668416b0acb6157534938ca83d4e909471e33a7d3c52
ToppCellCOVID-19-lung-Macrophage_metabolically_active|lung / Disease (COVID-19 only), tissue and cell type

DOCK2 RGL1 SLC1A3 HCK

2.29e-04196684a753d76d764c181eecb0e17a794a2e7d0ff70136
ToppCellChildren_(3_yrs)-Immune-monocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

DOCK2 XYLT1 HCK NOD2

2.29e-04196684cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCellCOVID-19-lung-Macrophage_metabolically_active|COVID-19 / Disease (COVID-19 only), tissue and cell type

DOCK2 RGL1 SLC1A3 HCK

2.29e-041966841b7928f4eee94d4bb6ea410bab68a471dba12979
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|COVID-19 / Disease (COVID-19 only), tissue and cell type

DOCK2 RGL1 SLC1A3 HCK

2.29e-041966847026c1fc33425e5476063d17c79e4b79356a9e01
Drug0393-0188; Down 200; 10uM; MCF7; HT_HG-U133A

RGL1 ZNF609 PDE9A SZT2 HUWE1 HCK ITPR3

1.60e-061966677531_DN
Drugtemephos

STAG1 KEAP1 SLC1A3 STAG2

2.47e-0633664CID000005392
DrugIsosorbide dinitrate [87-33-2]; Down 200; 17uM; HL60; HT_HG-U133A

CUL5 XYLT2 NF2 SLC22A5 FLCN RAB3IL1

2.23e-051966662183_DN
DrugAmodiaquin dihydrochloride dihydrate [6398-98-7]; Down 200; 8.6uM; HL60; HG-U133A

ZNF609 STAG1 BEX1 YLPM1 ANGEL1 ZMYM3

2.23e-051966661570_DN
DrugGibberellic acid [77-06-5]; Up 200; 11.6uM; HL60; HT_HG-U133A

NF2 SZT2 HUWE1 RAB3IL1 SLC1A3 NOD2

2.36e-051986662910_UP
DrugGibberellic acid [77-06-5]; Down 200; 11.6uM; MCF7; HT_HG-U133A

CUL5 ZNF609 NF2 SZT2 RAB3IL1 ADCY3

2.43e-051996667330_DN
DiseasePseudoxanthoma Elasticum, Incomplete

XYLT1 XYLT2

1.39e-053642C1867450
DiseasePseudoxanthoma elasticum

XYLT1 XYLT2

1.39e-053642cv:C0033847
DiseaseAutosomal recessive inherited pseudoxanthoma elasticum

XYLT1 XYLT2

1.39e-053642cv:C1275116
DiseasePSEUDOXANTHOMA ELASTICUM

XYLT1 XYLT2

1.39e-053642264800
DiseaseGronblad-Strandberg Syndrome

XYLT1 XYLT2

1.39e-053642C0376359
DiseasePseudoxanthoma Elasticum

XYLT1 XYLT2

2.77e-054642C0033847
DiseaseRenal carcinoma

NF2 FLCN

4.61e-055642C1378703
Diseaserenal cell carcinoma (implicated_via_orthology)

NF2 FLCN

6.91e-056642DOID:4450 (implicated_via_orthology)
DiseaseMalignant neoplasm of kidney

NF2 FLCN SDHB

1.29e-0445643C0740457
Diseasepseudoxanthoma elasticum (is_implicated_in)

XYLT1 XYLT2

1.65e-049642DOID:2738 (is_implicated_in)
Diseasepulmonary sarcoidosis (is_implicated_in)

CFTR NOD2

1.65e-049642DOID:13406 (is_implicated_in)
Diseasegastrointestinal stromal tumor (is_implicated_in)

NF2 SDHB

2.52e-0411642DOID:9253 (is_implicated_in)
Diseasewaist-hip ratio, body mass index

DOCK2 KEAP1

3.01e-0412642EFO_0004340, EFO_0004343
Diseasesmoking cessation

XYLT1 STAG1 IRF4 LRRN2 ITPR3

7.04e-04325645EFO_0004319
Diseaseserum IgG glycosylation measurement

DOCK2 ANGPT1 DNAH10 SLC22A5 FLCN MPRIP

9.47e-04523646EFO_0005193
DiseaseMental Retardation, X-Linked

ZMYM3 OPHN1

1.81e-0329642C1136249
Diseasereticulocyte measurement

CUL5 RGL1 ANGPT1 DNAH10 SLC22A5 TMC8 RAB3IL1 ADCY3

1.93e-031053648EFO_0010700
DiseaseCrohn's disease (is_implicated_in)

SLC22A5 NOD2

1.94e-0330642DOID:8778 (is_implicated_in)
Diseaseasthma, cardiovascular disease

SLC22A5 RANBP6

1.94e-0330642EFO_0000319, MONDO_0004979

Protein segments in the cluster

PeptideGeneStartEntry
LYLSTLRWFQMRIEM

CFTR

1091

P13569
MVEWLREVGMPADYV

CUL5

476

Q93034
EMMQARTYPLRWFLL

SERPINF2

266

P08697
RQPILQYRWDMMHRL

BEX1

56

Q9HBH7
WMYRSLMRISERPSV

CYLC2

76

Q14093
TSQRQYMLRIELMDW

ANGPT1

366

Q15389
YMLRIELMDWEGNRA

ANGPT1

371

Q15389
LQIMSEYLWDPERRM

ATP1B4

86

Q9UN42
LVRQDAEPMFWEIMR

RAB3IL1

351

Q8TBN0
TWAAVPRDRMLMFEE

RGL1

346

Q9NZL6
RRLWMEAMDGKEPIY

OPHN1

356

O60890
EMEWQRKLRSMPLIY

ITPR3

2181

Q14573
WMIMNDRLTEYPLVI

DPY19L2P1

166

Q6NXN4
MEQLFPRRCTWLYVM

MAP4K3

596

Q8IVH8
RYPVLMSRRVCWMII

OR2T1

181

O43869
RSVQLWPAMEYLAML

MDN1

2926

Q9NU22
EIVSGWLEMLMVYPR

MPRIP

136

Q6WCQ1
MMDRIYLINSWPFLL

FLCN

176

Q8NFG4
VHNYMMPPLDRSWRD

IRF4

166

Q15306
DSRWFEMLPNLEILM

LRRN2

181

O75325
TALSAPRYMDLLMDW

MOB3A

111

Q96BX8
PRYMDLLMDWIEAQI

MOB3A

116

Q96BX8
YLGRFQDRLMWIMIL

PCNX4

656

Q63HM2
EEIMLQPLWESRDRY

PDE9A

536

O76083
EIMLLPQWIHYTMVR

DNAH12

456

Q6ZR08
WMIMNDRLTEYPLII

DPY19L2

171

Q6NUT2
LLREWYMIISREMFN

HUWE1

4061

Q7Z6Z7
LYQMTPEMWEERITA

NF2

176

P35240
LYNIMMRCWKNRPEE

HCK

486

P08631
DMRRLIGFSIRDMWY

DOCK2

1061

Q92608
AYMRPLSIWAMQLAL

GBA2

876

Q9HCG7
EAIMRLVAVIMWYAP

SLC1A3

276

P43003
MELRSYQWEVIMPAL

DHX58

1

Q96C10
VYEMRRWNEALVTNM

ADCY3

881

O60266
YPERNEWRMITAMNT

KEAP1

491

Q14145
MPLSEDFVWMRARLQ

HAUS4

151

Q9H6D7
RMIPLMERIAWEIAE

DNAH10

386

Q8IVF4
DRSRVDWMLLYQGMV

DNAH10

1666

Q8IVF4
EIQQQWMLYMIRLDR

DNAH2

816

Q9P225
YFIRDWRMLLVALTM

SLC22A5

251

O76082
MEWLLELMGYIRNVA

FOCAD

1641

Q5VW36
RYMALLMDWIEGLIN

MOB3C

116

Q70IA8
NRYPDMSMREEIAVW

PITX1

111

P78337
NMRIEYVAMAPWPLE

SZT2

436

Q5T011
AMLEQVAMTERYRLW

SYN3

321

O14994
VEMMDRRPYWCISRQ

IARS2

511

Q9NSE4
VEYFRWPMLLNMRDN

RANBP6

911

O60518
EDAEEWTYPMRREMQ

STYX

16

Q8WUJ0
MMTLTNWYRYEPSRE

SERINC1

401

Q9NRX5
EDHYWEQLEPSLRMM

ANGEL1

301

Q9UNK9
YLQSMRDLLEMTDWP

XYLT1

401

Q86Y38
YAMMDKRLIWQLREP

TMC8

41

Q8IU68
FEDMAMYLTREEWRP

ZNF436

16

Q9C0F3
MYLTREEWRPLDAAQ

ZNF436

21

Q9C0F3
RRYIMEMLPITDWTA

UNC80

2561

Q8N2C7
PEQRWYMNRFVGILM

TM9SF4

491

Q92544
MPGFIWLIRSLYEMQ

NOD2

736

Q9HC29
MTFQMSLRREDVWLP

STAG2

1026

Q8N3U4
MYTRGRELEHWDEML

SYT15B

441

X6R8R1
MDPILWYRQEAEPRM

ZNF609

1126

O15014
LFWYRQTMMRGLELL

TRBV12-3

51

P01733
PWLLVIRSMERVMYV

SCAND2P

281

Q9GZW5
TEQMMERREDVWLPL

STAG1

1031

Q8WVM7
RQRIDPVLYMTEWFM

TBC1D10B

511

Q4KMP7
PMDMYDRSLDNEWDR

YLPM1

1296

P49750
LFWYRQTMMRGLELL

TRBV12-4

51

A0A0B4J2E0
VLMQAYRWMIDSRDD

SDHB

211

P21912
EMSMREDVYQRIVWL

THOP1

111

P52888
MYLRSMRDLLEVPGW

XYLT2

306

Q9H1B5
EWMMLDSAQRSLYRD

ZNF891

56

A8MT65
PLWYSVIPMDRSMLE

ZMYM3

1331

Q14202
PPSMLRYEEMTERWF

KLHL42

216

Q9P2K6
DDMRELPPWMYGLRN

LRRC8C

501

Q8TDW0