Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	molecular adaptor activity	SPTBN4 FEM1B FCRL2 TRPC4AP HDAC4 NDC80 TONSL SLMAP MED14 MED12L MLLT3 MICAL3 SORBS1 FLRT2 CNTLN MAP2K1 WNK3 PCNT	1.96e-06	1356	75	18	GO:0060090
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	SPTBN4 FEM1B FCRL2 TRPC4AP HDAC4 NDC80 TONSL SLMAP MED14 MED12L SORBS1 FLRT2 CNTLN MAP2K1 WNK3	2.24e-05	1160	75	15	GO:0030674
GeneOntologyMolecularFunction	indanol dehydrogenase activity	AKR1B10 AKR1B15	8.31e-05	4	75	2	GO:0047718
GeneOntologyMolecularFunction	allyl-alcohol dehydrogenase activity	AKR1B10 AKR1B15	8.31e-05	4	75	2	GO:0047655
GeneOntologyMolecularFunction	geranylgeranyl reductase activity	AKR1B10 AKR1B15	2.07e-04	6	75	2	GO:0045550
GeneOntologyMolecularFunction	NADP+ binding	AKR1B10 AKR1B15	4.93e-04	9	75	2	GO:0070401
GeneOntologyMolecularFunction	retinoid binding	UGT1A1 AKR1B10 AKR1B15	7.80e-04	48	75	3	GO:0005501
GeneOntologyMolecularFunction	isoprenoid binding	UGT1A1 AKR1B10 AKR1B15	8.28e-04	49	75	3	GO:0019840
GeneOntologyMolecularFunction	retinal dehydrogenase activity	AKR1B10 AKR1B15	1.23e-03	14	75	2	GO:0001758
GeneOntologyMolecularFunction	aldose reductase (NADPH) activity	AKR1B10 AKR1B15	1.23e-03	14	75	2	GO:0004032
GeneOntologyMolecularFunction	all-trans-retinol dehydrogenase (NADP+) activity	AKR1B10 AKR1B15	1.42e-03	15	75	2	GO:0052650
GeneOntologyCellularComponent	centrosome	NDC80 PSKH1 SLMAP PKHD1 RASSF10 SORBS1 CNTLN CCDC77 MAP2K1 NPHP4 PCNT NIN	1.78e-05	770	75	12	GO:0005813
GeneOntologyCellularComponent	microtubule organizing center	NDC80 PSKH1 SLMAP PKHD1 RASSF10 SORBS1 CNTLN CCDC77 MAP2K1 NPHP4 ODAD3 PCNT NIN	2.12e-05	919	75	13	GO:0005815
GeneOntologyCellularComponent	nuclear protein-containing complex	RGPD2 TFPT HDAC4 EP400 ZNF335 TONSL MED14 MED12L MLLT3 LSM10 CLOCK DIS3 AQR PHC2	3.42e-04	1377	75	14	GO:0140513
GeneOntologyCellularComponent	centriole	CNTLN NPHP4 ODAD3 PCNT NIN	3.86e-04	172	75	5	GO:0005814
Domain	ALDOKETO_REDUCTASE_1	AKR1B10 AKR1B15	6.64e-04	10	73	2	PS00798
Domain	Aldo/ket_reductase_CS	AKR1B10 AKR1B15	6.64e-04	10	73	2	IPR018170
Domain	Aldo/keto_reductase	AKR1B10 AKR1B15	6.64e-04	10	73	2	IPR020471
Domain	ALDOKETO_REDUCTASE_2	AKR1B10 AKR1B15	6.64e-04	10	73	2	PS00062
Domain	ALDOKETO_REDUCTASE_3	AKR1B10 AKR1B15	6.64e-04	10	73	2	PS00063
Domain	-	AKR1B10 AKR1B15	1.75e-03	16	73	2	3.20.20.100
Domain	NADP_OxRdtase_dom	AKR1B10 AKR1B15	1.97e-03	17	73	2	IPR023210
Domain	CarboxyPept-like_regulatory	CPN1 TENM2	1.97e-03	17	73	2	IPR008969
Domain	Aldo_ket_red	AKR1B10 AKR1B15	1.97e-03	17	73	2	PF00248
Domain	Aldo/ket_red/Kv-b	AKR1B10 AKR1B15	1.97e-03	17	73	2	IPR001395
Domain	CH	SPTBN4 MICAL3 UTRN	2.10e-03	65	73	3	SM00033
Domain	CH	SPTBN4 MICAL3 UTRN	2.60e-03	70	73	3	PF00307
Domain	-	SPTBN4 MICAL3 UTRN	2.71e-03	71	73	3	1.10.418.10
Domain	CH	SPTBN4 MICAL3 UTRN	2.93e-03	73	73	3	PS50021
Domain	CH-domain	SPTBN4 MICAL3 UTRN	3.16e-03	75	73	3	IPR001715
Domain	Actinin_actin-bd_CS	SPTBN4 UTRN	3.61e-03	23	73	2	IPR001589
Domain	Spectrin	SPTBN4 UTRN	3.61e-03	23	73	2	PF00435
Domain	ACTININ_2	SPTBN4 UTRN	3.61e-03	23	73	2	PS00020
Domain	ACTININ_1	SPTBN4 UTRN	3.61e-03	23	73	2	PS00019
Domain	TPR_REGION	FEM1B RGPD2 TONSL ZFC3H1	3.98e-03	165	73	4	PS50293
Domain	TPR	FEM1B RGPD2 TONSL ZFC3H1	3.98e-03	165	73	4	PS50005
Domain	Spectrin_repeat	SPTBN4 UTRN	5.71e-03	29	73	2	IPR002017
Domain	Spectrin/alpha-actinin	SPTBN4 UTRN	6.93e-03	32	73	2	IPR018159
Domain	SPEC	SPTBN4 UTRN	6.93e-03	32	73	2	SM00150
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FEM1B IQSEC3 EP400 SRGAP3 MTMR3 MICAL3 SORBS1 TENM2 VPS13B AQR PCNT	1.23e-09	407	75	11	12693553
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	EP400 NDC80 TONSL MED14 MICAL3 CCDC77 UTRN DENND4C PHC2 PCNT NIN	1.37e-07	645	75	11	25281560
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	HDAC4 SLMAP MTMR3 SORBS1 CCDC77 MAP2K1 UTRN DENND4C NIN	5.14e-07	446	75	9	24255178
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	SALL2 EP400 NDC80 INPPL1 TONSL SORBS1 CNTLN DIS3 PCNT NIN	5.47e-07	588	75	10	38580884
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SPRY2 HIVEP2 CLCN7 EP400 INPPL1 ZNF335 MTMR3 MED14 MICAL3 NPHP4 LSM10 PHC2 PCNT	6.39e-07	1105	75	13	35748872
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SPTBN4 SLMAP MED12L WNK3 NIN	2.75e-06	101	75	5	10997877
Pubmed	Role of AKR1B10 and AKR1B8 in the pathogenesis of non-alcoholic steatohepatitis (NASH) in mouse.	AKR1B10 AKR1B15	4.59e-06	2	75	2	34954342
Pubmed	Aldo-keto reductase family 1 member B8 is secreted via non-classical pathway.	AKR1B10 AKR1B15	4.59e-06	2	75	2	25120755
Pubmed	Murine aldo-keto reductase family 1 subfamily B: identification of AKR1B8 as an ortholog of human AKR1B10.	AKR1B10 AKR1B15	4.59e-06	2	75	2	21087085
Pubmed	Tissue-specific expression of two aldose reductase-like genes in mice: abundant expression of mouse vas deferens protein and fibroblast growth factor-regulated protein in the adrenal gland.	AKR1B10 AKR1B15	4.59e-06	2	75	2	8526877
Pubmed	AKR1B8 deficiency drives severe DSS-induced acute colitis through invasion of luminal bacteria and activation of innate immunity.	AKR1B10 AKR1B15	4.59e-06	2	75	2	36518763
Pubmed	1.7 A structure of FR-1, a fibroblast growth factor-induced member of the aldo-keto reductase family, complexed with coenzyme and inhibitor.	AKR1B10 AKR1B15	4.59e-06	2	75	2	7578036
Pubmed	Characterization of the promoter of the gene for a mouse vas deferens protein related to the aldo-keto reductase superfamily: effect of steroid hormones and phorbol esters.	AKR1B10 AKR1B15	4.59e-06	2	75	2	8541228
Pubmed	Impaired Barrier Function and Immunity in the Colon of Aldo-Keto Reductase 1B8 Deficient Mice.	AKR1B10 AKR1B15	4.59e-06	2	75	2	33644071
Pubmed	Impaired self-renewal and increased colitis and dysplastic lesions in colonic mucosa of AKR1B8-deficient mice.	AKR1B10 AKR1B15	4.59e-06	2	75	2	25538260
Pubmed	Functional expression of novel human and murine AKR1B genes.	AKR1B10 AKR1B15	4.59e-06	2	75	2	21276782
Pubmed	Compensatory upregulation of aldo-keto reductase 1B10 to protect hepatocytes against oxidative stress during hepatocarcinogenesis.	AKR1B10 AKR1B15	4.59e-06	2	75	2	31911858
Pubmed	Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.	FEM1B SRGAP3 FLRT2 PCNT	4.99e-06	52	75	4	9455477
Pubmed	USP7 Regulates Cytokinesis through FBXO38 and KIF20B.	GMPS EP400 ZFC3H1 CCDC77 TFAP4	5.42e-06	116	75	5	30804394
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	SPTBN4 FEM1B HDAC4 EP400 SORBS1	9.45e-06	130	75	5	12421765
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	LMBR1L DISP3 TAOK1 MICAL3 ANKRD24 FLRT2 ZFC3H1 NPHP4	1.13e-05	493	75	8	15368895
Pubmed	PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.	EP400 MED14 PHC2 HMG20A	1.22e-05	65	75	4	22496869
Pubmed	Substrate specificity and catalytic efficiency of aldo-keto reductases with phospholipid aldehydes.	AKR1B10 AKR1B15	1.37e-05	3	75	2	17381426
Pubmed	A delayed-early gene activated by fibroblast growth factor-1 encodes a protein related to aldose reductase.	AKR1B10 AKR1B15	1.37e-05	3	75	2	7510692
Pubmed	Expression of three spalt (sal) gene homologues in zebrafish embryos.	SALL2 SALL3	1.37e-05	3	75	2	12590351
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SPTBN4 SPRY2 HIVEP2 MTMR3 MLLT3 TAOK1 ANKRD24 SORBS1 ZFC3H1 UTRN HMG20A PCNT	1.87e-05	1285	75	12	35914814
Pubmed	Regulation and function of Spalt proteins during animal development.	SALL2 SALL3	2.75e-05	4	75	2	19247946
Pubmed	The vertebrate spalt genes in development and disease.	SALL2 SALL3	2.75e-05	4	75	2	16545361
Pubmed	The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2.	INPPL1 SORBS1	2.75e-05	4	75	2	12504111
Pubmed	Identification of genes and networks driving cardiovascular and metabolic phenotypes in a mouse F2 intercross.	AKR1B10 AKR1B15	2.75e-05	4	75	2	21179467
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	HDAC4 ZBTB48 EP400 INPPL1 TONSL RNF11 PCNT	4.05e-05	430	75	7	35044719
Pubmed	CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis.	NDUFA9 CLOCK	4.57e-05	5	75	2	28985504
Pubmed	Comparisons of genomic structures and chromosomal locations of the mouse aldose reductase and aldose reductase-like genes.	AKR1B10 AKR1B15	4.57e-05	5	75	2	10092857
Pubmed	Butylated hydroxyanisole induces distinct expression patterns of Nrf2 and detoxification enzymes in the liver and small intestine of C57BL/6 mice.	AKR1B10 AKR1B15	4.57e-05	5	75	2	26291391
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	ZBTB48 EP400 TONSL MED14 ZFC3H1 DIS3 TFAP4	5.62e-05	453	75	7	29656893
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	GMPS FEM1B TFPT HIVEP2 SLMAP UTRN DIS3 TFAP4 AQR NIN	5.88e-05	1005	75	10	19615732
Pubmed	Zinc finger protein sall2 is not essential for embryonic and kidney development.	SALL2 SALL3	6.84e-05	6	75	2	12482961
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	GMPS SPTBN4 TRPC4AP HIVEP2 HDAC4 ANXA6 MICAL3 ANKRD24 UTRN TFAP4 VPS13B PCNT	7.79e-05	1489	75	12	28611215
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	NDC80 ANXA6 CCDC50 MICAL3 SORBS1 CNTLN CCDC77 PCNT NIN	9.10e-05	853	75	9	28718761
Pubmed	SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses.	IQSEC3 UTRN	9.57e-05	7	75	2	21198641
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	HIVEP2 HDAC4 INPPL1 SORBS1 MAP2K1 UTRN WNK3 DENND4C AQR	9.77e-05	861	75	9	36931259
Pubmed	Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons.	HIVEP2 FLRT2 PALMD	1.04e-04	42	75	3	24997765
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	SALL2 SRGAP3 DIS3 PCNT NIN	1.29e-04	225	75	5	12168954
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	ZNF335 MED14 TAOK1 UTRN DIS3 NIN	1.36e-04	363	75	6	14691545
Pubmed	A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation.	PCNT NIN	2.04e-04	10	75	2	25220058
Pubmed	BCoR, a novel corepressor involved in BCL-6 repression.	HDAC4 MLLT3	2.04e-04	10	75	2	10898795
Pubmed	The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons.	FEM1B TRPC4AP	2.04e-04	10	75	2	29779948
Pubmed	Parkin ubiquitinates and promotes the degradation of RanBP2.	RGPD2 HDAC4	2.04e-04	10	75	2	16332688
Pubmed	Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development.	FLRT2 TENM2	2.04e-04	10	75	2	38713721
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SPTBN4 RGPD2 IQSEC3 HDAC4 SRGAP3 SORBS1 TENM2 WNK3 PCNT	2.26e-04	963	75	9	28671696
Pubmed	RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.	RGPD2 HK1	2.49e-04	11	75	2	17069463
Pubmed	Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.	CCDC77 NPHP4 PCNT NIN	2.87e-04	146	75	4	21399614
Pubmed	Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development.	SALL2 SALL3	2.99e-04	12	75	2	11688560
Pubmed	A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart.	SLMAP MTMR3 SORBS1	3.02e-04	60	75	3	19075228
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	GMPS DFFA EP400 MED14 DIS3 TFAP4 AQR PHC2 HMG20A	3.29e-04	1014	75	9	32416067
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	HK1 CLCN7 SLMAP ZFC3H1 CCDC77 NDUFA9 MAP2K1 VPS13B AQR PCNT NIN	3.33e-04	1487	75	11	33957083
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	DISP3 TAOK1 MICAL3 SORBS1	3.43e-04	153	75	4	10718198
Pubmed	Sox2-Evf2 lncRNA-mediated mechanisms of chromosome topological control in developing forebrain.	AKR1B10 AKR1B15	3.52e-04	13	75	2	33593819
Pubmed	Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool.	PCNT NIN	3.52e-04	13	75	2	17920017
Pubmed	Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3.	SPRY2 FLRT2	3.52e-04	13	75	2	18448090
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	HDAC4 EP400 MLLT3 PHC2	3.79e-04	157	75	4	30186101
Pubmed	p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.	TAOK1 CCDC77 UTRN PCNT	3.97e-04	159	75	4	30581152
Pubmed	Coordinated activity of Spry1 and Spry2 is required for normal development of the external genitalia.	SPRY2 MAP2K1	4.11e-04	14	75	2	24361260
Pubmed	Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.	TAOK1 MICAL3 SORBS1	4.18e-04	67	75	3	29254152
Pubmed	Genetic interaction mapping in mammalian cells using CRISPR interference.	EP400 MED14 PHC2	4.56e-04	69	75	3	28481362
Pubmed	Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.	GMPS MLLT3 DIS3 TFAP4 HMG20A PCNT	4.67e-04	457	75	6	32968282
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	SALL2 SALL3 EP400 MED14	4.78e-04	167	75	4	20362541
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	GMPS HK1 ANXA6 UTRN DIS3 AQR PCNT	5.24e-04	653	75	7	22586326
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	FEM1B SALL3 CCDC50 TAOK1 CCDC77 UTRN DIS3 VPS13B PCNT	5.34e-04	1084	75	9	11544199
Pubmed	A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells.	ZNF335 MLLT3 SORBS1	5.37e-04	73	75	3	22094256
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	HK1 EP400 PHC2 HMG20A	5.95e-04	177	75	4	26206133
Pubmed	Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.	LMBR1L SRGAP3 TENM2	6.05e-04	76	75	3	10574461
Pubmed	An inter-species protein-protein interaction network across vast evolutionary distance.	SPRY2 TFPT NDC80 DDI1 PHC2 HMG20A	6.23e-04	483	75	6	27107014
Pubmed	Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2.	ZNF335 CLOCK TFAP4	6.28e-04	77	75	3	19505873
Pubmed	Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking.	CLCN7 MTMR3	6.87e-04	18	75	2	26598607
Pubmed	Monitoring protein-protein interactions in mammalian cells by trans-SUMOylation.	MAP2K1 PHC2	6.87e-04	18	75	2	21675959
Pubmed	Murine inner cell mass-derived lineages depend on Sall4 function.	SALL2 SALL3	6.87e-04	18	75	2	17060609
Pubmed	Loss of microRNAs in neural crest leads to cardiovascular syndromes resembling human congenital heart defects.	SPRY2 MAP2K1	7.66e-04	19	75	2	20884876
Pubmed	The ciliary protein Ftm is required for ventricular wall and septal development.	MAP2K1 PCNT	7.66e-04	19	75	2	23469020
Pubmed	Next-generation sequencing to generate interactome datasets.	SPRY2 ZBTB48 CLCN7 EP400 LMBR1L DDI1 TFAP4 RNF11 PHC2	7.98e-04	1147	75	9	21516116
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	IQSEC3 SRGAP3 TAOK1 MICAL3 SORBS1	9.36e-04	347	75	5	17114649
Pubmed	Analysis of FGF20-regulated genes in organ of Corti progenitors by translating ribosome affinity purification.	SALL2 SALL3	9.38e-04	21	75	2	32492250
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	PKHD1 ZFC3H1 MAP2K1 AQR	9.73e-04	202	75	4	24639526
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	SPTBN4 IQSEC3 HK1 SRGAP3 AKR1B10 MICAL3 SORBS1 NDUFA9 MAP2K1 UTRN	9.81e-04	1431	75	10	37142655
Pubmed	Interaction network of human early embryonic transcription factors.	HIVEP2 HDAC4 EP400 NDUFA9 TFAP4	9.85e-04	351	75	5	38297188
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	EP400 SLMAP MED12L CLOCK DIS3 NIN	9.98e-04	529	75	6	14621295
Pubmed	DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.	SPTBN4 PCNT	1.03e-03	22	75	2	12812986
Pubmed	Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor.	TFPT INPPL1 SORBS1	1.05e-03	92	75	3	20368287
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	INPPL1 MICAL3 UTRN DENND4C	1.10e-03	209	75	4	36779422
Pubmed	The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map.	SPRY2 TENM2 NIN	1.12e-03	94	75	3	23431145
Pubmed	Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development.	SALL2 SALL3	1.13e-03	23	75	2	20159597
Pubmed	Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity.	NDC80 PCNT	1.13e-03	23	75	2	36973253
Pubmed	Etv transcription factors functionally diverge from their upstream FGF signaling in lens development.	SPRY2 MAP2K1	1.23e-03	24	75	2	32043969
Pubmed	Gene network analysis in a pediatric cohort identifies novel lung function genes.	MED12L MICAL3	1.23e-03	24	75	2	24023788
Pubmed	High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.	MAP2K1 AQR	1.33e-03	25	75	2	26627737
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TFPT EP400 MED14 CCDC50 ZFC3H1 NDUFA9 UTRN AQR PHC2 HMG20A	1.38e-03	1497	75	10	31527615
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	EP400 ZFC3H1 CCDC77 NDUFA9	1.38e-03	222	75	4	37071664
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	EP400 ZNF335 MED14 TAOK1 MICAL3 TFAP4 PHC2	1.41e-03	774	75	7	15302935
Pubmed	Centrosome-related genes, genetic variation, and risk of breast cancer.	NDC80 PCNT NIN	1.42e-03	102	75	3	20508983
Pubmed	Epidermal development requires ninein for spindle orientation and cortical microtubule organization.	PCNT NIN	1.44e-03	26	75	2	30923192
Cytoband	16p13	CLCN7 TFAP4	2.03e-04	13	75	2	16p13
Cytoband	12p13.33	IQSEC3 CCDC77	4.42e-04	19	75	2	12p13.33
Cytoband	Ensembl 112 genes in cytogenetic band chr6p12	CRISP1 PKHD1 IL17F	1.66e-03	142	75	3	chr6p12
Cytoband	7q33	AKR1B10 AKR1B15	2.07e-03	41	75	2	7q33
Cytoband	Ensembl 112 genes in cytogenetic band chr9p22	CNTLN DENND4C	3.44e-03	53	75	2	chr9p22
GeneFamily	Aldo-keto reductases	AKR1B10 AKR1B15	8.00e-04	15	51	2	399
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	GMPS HIVEP2 HDAC4 NDC80 MTMR3 MICAL3 FLRT2 MAP2K1 CLOCK VPS13B AQR PCNT	5.38e-06	856	75	12	M4500
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	TAOK1 CLOCK UTRN VPS13B DENND4C AQR	9.08e-07	193	75	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZBTB48 AKR1B10 GALNT12 ODAD3 PCNT	7.32e-06	159	75	5	7c2f70a7cba880115ccd676fb6c5f18488a5b74f
Disease	Intellectual Disability	IQSEC3 HIVEP2 HK1 HDAC4 SRGAP3 ZNF335 MED12L TAOK1	1.64e-05	447	74	8	C3714756
Disease	smoking status measurement, chronic obstructive pulmonary disease	HDAC4 RASSF10 GALNT12 MICAL3	7.25e-05	88	74	4	EFO_0000341, EFO_0006527
Disease	symmetrical dimethylarginine measurement	AKR1B10 AKR1B15	2.21e-04	9	74	2	EFO_0006523
Disease	chronic obstructive pulmonary disease	HIVEP2 HDAC4 SRGAP3 SLMAP MTMR3 RASSF10 GALNT12 MICAL3	3.26e-04	688	74	8	EFO_0000341
Disease	gestational age	SLMAP CNTLN UTRN TFAP4	4.09e-04	138	74	4	EFO_0005112
Disease	cataract	GMPS MTMR3 FLRT2 PCNT	4.44e-04	141	74	4	MONDO_0005129
Disease	Cleft palate, cleft lip	SPRY2 MTMR3 PKHD1 TENM2 VPS13B	6.90e-04	279	74	5	EFO_0003959, HP_0000175
Disease	Contact Dermatitis	UGT1A1 HDAC4 AKR1B10	7.66e-04	71	74	3	C0011616
Disease	Contact hypersensitivity	UGT1A1 HDAC4 AKR1B10	7.66e-04	71	74	3	C0162351
Disease	FEV/FEC ratio	SPRY2 HIVEP2 HDAC4 SRGAP3 SLMAP MTMR3 RASSF10 GALNT12 MICAL3 TFAP4	9.59e-04	1228	74	10	EFO_0004713
Disease	maximal midexpiratory flow rate	MED12L MICAL3	1.14e-03	20	74	2	EFO_0004313
Disease	nose morphology measurement	SRGAP3 PKHD1 MLLT3 SORBS1 VPS13B	1.44e-03	329	74	5	EFO_0007843
Disease	obesity (is_implicated_in)	HK1 INPPL1 SORBS1	1.57e-03	91	74	3	DOID:9970 (is_implicated_in)
Disease	peak expiratory flow	HDAC4 SLMAP GALNT12 MICAL3 TFAP4 HMG20A	1.58e-03	498	74	6	EFO_0009718
Disease	red blood cell density measurement	HK1 EP400 PSKH1 PKHD1 SORBS1 VPS13B PHC2 HMG20A	1.61e-03	880	74	8	EFO_0007978
Disease	cortical thickness	SLAMF6 SRGAP3 MTMR3 PKHD1 GALNT12 MICAL3 CLOCK TENM2 TFAP4	1.83e-03	1113	74	9	EFO_0004840
Disease	blood cadmium measurement	RASSF10 MLLT3	1.94e-03	26	74	2	EFO_0007576

Protein segments in the cluster

Peptide	Gene	Start	Entry
LTEQITLENQVHQRI	EP400	771	Q96L91
ETLQRLISEQLQQLH	DISP3	146	Q9P2K9
VQRNRLVQHDLQVAK	CCDC50	46	Q8IVM0
LQNDVHVVRRQIREL	CNTLN	1291	Q9NXG0
TLRERHILQQIVNLI	MLLT3	516	P42568
RIHLEEIQVQHQRNQ	CCDC77	251	Q9BR77
AQVLIRFHIQRNVIV	AKR1B10	246	O60218
LLVSRHERRISQIQQ	AQR	406	O60306
LQHTLQQVLDQREEV	DFFA	171	O00273
HILERQVQELQQLLV	ANKRD24	361	Q8TF21
VRVLHLQENNIQTIS	FLRT2	111	O43155
IIDIITHRSNVQRQQ	ANXA6	386	P08133
QEEIVNIHNALRRRV	CRISP1	41	P54107
AIRNQIIRELQVLHE	MAP2K1	106	Q02750
LVLSQDHTIRQQVQR	RASSF10	231	A6NK89
NLVVLQELVVDHNRI	LRRC9	1246	Q6ZRR7
QRIIGRVHLAQIQIE	DDI1	296	Q8WTU0
RVLDQQHILQVQSLQ	MSANTD1	246	Q6ZTZ1
DQHQIQVLEQSILRL	PALMD	71	Q9NP74
KRLHRAQIIQRQLQQ	MICAL3	1846	Q7RTP6
RQILIAEFQRQHEQL	HDAC4	86	P56524
RQQALLLEQQRIHQL	HDAC4	591	P56524
TSTIEQQLQIIHRVR	LSM10	91	Q969L4
LQRQHIKRILQNLEQ	MED12L	1306	Q86YW9
VIQERSRNTVLQQHL	HMG20A	271	Q9NP66
VLRRVRHANIIQLVE	PSKH1	146	P11801
VVRLLLEHYRVQTQQ	FEM1B	61	Q9UK73
LRHLVVVDNRNQVVG	CLCN7	766	P51798
LIQERQEIIARIAQH	FAM214A	366	Q32MH5
RILRVQVNHEKNQNV	HK1	91	P19367
IVQNQQSLIHTQRER	IQSEC3	21	Q9UPP2
IRRVVQHSNVVINLI	NDUFA9	116	Q16795
LQLLQERHQQQLLSV	PCNT	901	O95613
VPIQQETLVVRRKHQ	IL17F	121	Q96PD4
QQSVRTQHLRDLQVI	NPHP4	941	O75161
MRRHLQRIIQQETLQ	MED14	1216	O60244
LNRALNQEQVIAVHI	GMPS	256	P49915
NQRIVQLIQDTRIHI	CPN1	111	P15169
LVETIRQSIQHNNVL	DENND4C	1811	Q5VZ89
LRLQEESVRLHQINI	GALNT12	91	Q8IXK2
IRKQSLQSQIHVQRI	FCRL2	186	Q96LA5
LILEELRVLQQRQIH	SALL2	181	Q9Y467
QIHQLQLIEQIRSQV	SALL3	216	Q9BXA9
REQVHLIQNAIIESR	IZUMO4	111	Q1ZYL8
TIQQRLRQIESGHQQ	MTMR3	1026	Q13615
EQIRIAQRIGLIQHL	RNF11	66	Q9Y3C5
RVHALNNVNRVLQVL	UTRN	86	P46939
ILRQLRNIQVTNHSQ	SLAMF6	126	Q96DU3
RLINIIHVQTLTQEN	TRPC4AP	671	Q8TEL6
HRQVLALQTQRVLLE	LMBR1L	271	Q6UX01
IQTHQERPRVQNQVI	NIN	1416	Q8N4C6
LRLVVQHEINTLRAQ	RGPD2	551	P0DJD1
VKQQNALRHQVVLRQ	ODAD3	161	A5D8V7
HDRIRQLIKSQRVQN	INPPL1	361	O15357
ELIRLQHQTELTNQL	TAOK1	676	Q7L7X3
VLENNVILRITENHQ	TENM2	1431	Q9NT68
HQIRVRAQRLPEVQV	PKHD1	491	P08F94
RNVIVLQTVLQEVRN	DIS3	86	Q9Y2L1
QQVHVLSLDQIRAIR	SPRY2	36	O43597
AQVLIRFHIQRNVTV	AKR1B15	246	C9JRZ8
IHRQQEELRKIQEQL	CLOCK	541	O15516
VQHSVRVLQELNKQR	ZBTB48	6	P10074
IPDRQTVQVIQQALH	PHC2	51	Q8IXK0
EIEQVNERVLNRLHQ	TFPT	91	P0C1Z6
NERVLNRLHQVQRIT	TFPT	96	P0C1Z6
ERVHQIQQILVTLPR	SRGAP3	611	O43295
LQHVLAVVRLQQQLE	TONSL	286	Q96HA7
QVLQAQLQRLHIDTE	SLMAP	546	Q14BN4
IVNPTIVLLQHNREQ	SORBS1	306	Q9BX66
IVLLQHNREQQKRLS	SORBS1	311	Q9BX66
AIQQLQQRGHEIVVL	UGT1A1	46	P22309
EHDLQLLVSQVRQLQ	SPTBN4	1881	Q9H254
QSLIRRVVNNVNIVI	VPS13B	141	Q7Z7G8
VRQHNIQVPEIRVTE	HIVEP2	881	P31629
RLQQALSQEHIIVAQ	ZNF335	1176	Q9H4Z2
RQNLDTIVQAIQHIE	TFAP4	266	Q01664
KLQEQIHRVQQRVTI	ZFC3H1	891	O60293
TEVDQHVRQQLLQRK	WNK3	541	Q9BYP7
IERINHERNELQQTI	NDC80	366	O14777