Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1D CACNA1F

1.83e-0414292GO:0008331
GeneOntologyMolecularFunctionribosomal small subunit binding

MTIF3 MTIF2

2.73e-0417292GO:0043024
GeneOntologyBiologicalProcessmitochondrial translational initiation

MTIF3 MTIF2

1.91e-062292GO:0070124
GeneOntologyBiologicalProcessimport into cell

CACNA1D CACNA1F HEATR5A INPP5F SLC12A1 SYT8 NSF LEPR

8.48e-051074298GO:0098657
MousePhenoincreased magnesium level

TRMT10A SLC12A1 TRRAP

8.59e-0626223MP:0031659
MousePhenoincreased circulating magnesium level

TRMT10A SLC12A1 TRRAP

8.59e-0626223MP:0010092
MousePhenoincreased creatinine clearance

SLC12A1 LEPR

1.42e-054222MP:0005557
MousePhenoabnormal circulating HDL cholesterol level

ASPM PTPN23 TRMT10A LTK NSF LEPR

5.85e-05460226MP:0000184
MousePhenoabnormal magnesium level

TRMT10A SLC12A1 TRRAP

5.95e-0549223MP:0020883
MousePhenoabnormal circulating magnesium level

TRMT10A SLC12A1 TRRAP

5.95e-0549223MP:0001771
MousePhenoabnormal magnesium ion homeostasis

TRMT10A SLC12A1 TRRAP

6.32e-0550223MP:0011979
MousePhenoabnormal circulating lipoprotein level

ASPM PTPN23 TRMT10A LTK NSF LEPR

1.32e-04533226MP:0010330
MousePhenoabnormal lipoprotein level

ASPM PTPN23 TRMT10A LTK NSF LEPR

1.32e-04533226MP:0010329
MousePhenoabnormal kidney papilla morphology

SLC12A1 LEPR

3.56e-0418222MP:0004193
MousePhenoabnormal kidney pyramid morphology

SLC12A1 LEPR

3.98e-0419222MP:0004192
MousePhenoincreased pancreatic alpha cell number

CACNA1D LEPR

4.42e-0420222MP:0009176
MousePhenoincreased circulating HDL cholesterol level

ASPM PTPN23 LTK LEPR

4.71e-04238224MP:0001556
DomainCAC1F_C

CACNA1D CACNA1F

6.50e-063282PF16885
DomainCAC1F_C

CACNA1D CACNA1F

6.50e-063282IPR031688
DomainVDCC_L_a1su

CACNA1D CACNA1F

1.30e-054282IPR005446
DomainGPHH_dom

CACNA1D CACNA1F

4.53e-057282IPR031649
DomainVDCC_a1su_IQ

CACNA1D CACNA1F

4.53e-057282IPR014873
DomainCa_chan_IQ

CACNA1D CACNA1F

4.53e-057282SM01062
DomainCa_chan_IQ

CACNA1D CACNA1F

4.53e-057282PF08763
DomainGPHH

CACNA1D CACNA1F

4.53e-057282PF16905
DomainVDCCAlpha1

CACNA1D CACNA1F

9.68e-0510282IPR002077
DomainTPR-contain_dom

PTPN23 CRNKL1 TMTC2

1.44e-03150283IPR013026
DomainChannel_four-helix_dom

CACNA1D CACNA1F

3.29e-0357282IPR027359
Domain-

CACNA1D CACNA1F

3.29e-03572821.20.120.350
Domain-

CRNKL1 TMTC2 TRRAP

3.58e-032072831.25.40.10
Domain-

ASPM HEATR5A TRRAP

4.36e-032222831.25.10.10
DomainTPR-like_helical_dom

CRNKL1 TMTC2 TRRAP

4.99e-03233283IPR011990
DomainARM-like

ASPM HEATR5A TRRAP

7.49e-03270283IPR011989
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1D CACNA1F

3.80e-056232M47762
PathwayREACTOME_SIGNALING_BY_LTK

LTK SOS1

1.39e-0411232MM17235
PathwayREACTOME_SIGNALING_BY_LTK

LTK SOS1

1.66e-0412232M48256
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01004

CACNA1D CACNA1F

2.29e-0414232M47692
Pubmed

C-terminal modulator controls Ca2+-dependent gating of Ca(v)1.4 L-type Ca2+ channels.

CACNA1D CACNA1F

6.71e-07229216921373
Pubmed

Identification of mammalian mitochondrial translational initiation factor 3 and examination of its role in initiation complex formation with natural mRNAs.

MTIF3 MTIF2

6.71e-07229212095986
Pubmed

Voltage-Gated Cav1 Channels in Disorders of Vision and Hearing.

CACNA1D CACNA1F

6.71e-07229225966695
Pubmed

Upregulation of renal Na-K-2Cl cotransporter 2 in obese diabetes mellitus via a vasopressin receptor 2-dependent pathway.

SLC12A1 LEPR

2.01e-06329232035616
Pubmed

Genetic dissection of horizontal cell inhibitory signaling in mice in complete darkness in vivo.

CACNA1D CACNA1F

2.01e-06329226024096
Pubmed

Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.

CACNA1D CACNA1F

4.02e-06429220937870
Pubmed

Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.

CACNA1D CACNA1F

1.41e-05729212900400
Pubmed

Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.

CACNA1D CACNA1F

1.87e-05829228330839
Pubmed

NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.

CACNA1D CACNA1F

3.68e-051129218809727
Pubmed

Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study.

MTIF3 MTIF2

5.21e-051329219209188
Pubmed

Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.

CACNA1D CACNA1F

7.00e-051529220188150
Pubmed

Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.

MED24 TRRAP

7.00e-051529218418385
Pubmed

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.

CACNA1D CACNA1F

7.00e-051529224453333
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

ASPM NARS1 MED24 SLC12A1 TRRAP ZRANB1 SOS1

8.64e-05132729732694731
Pubmed

A genetic linkage map of mouse chromosome 2 extending from thrombospondin to paired box gene 1, including the H3 minor histocompatibility complex.

LTK SLC12A1

2.69e-04292928617512
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

MED24 DNAH3 IK TRRAP

3.58e-0441029426949251
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

MED24 PTPN23 TRRAP NSF ZRANB1

3.64e-0475429535906200
Pubmed

Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency.

NARS1 SLC12A1

3.70e-043429235341793
Pubmed

Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC).

CRNKL1 NSF

4.39e-043729216396496
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

CACNA1D CACNA1F

4.63e-043829230786075
Pubmed

Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease.

MED24 MYMK

4.88e-043929238690566
Pubmed

Large-scale structural analysis of the classical human protein tyrosine phosphatome.

NSF LEPR

7.09e-044729219167335
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

ASPM NARS1 PTPN23 CRNKL1 IK TRRAP

7.54e-04135329629467282
Pubmed

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

ASPM CRNKL1 IK TRRAP

7.88e-0450629430890647
InteractionCPPED1 interactions

ASPM NARS1 ZRANB1

2.05e-0619273int:CPPED1
InteractionIARS2 interactions

ASPM NARS1 MTIF3 ZRANB1 MTIF2

2.78e-05273275int:IARS2
InteractionPNPT1 interactions

MTIF3 TRRAP ZRANB1 MTIF2

3.97e-05145274int:PNPT1
InteractionHSDL2 interactions

MTIF3 TRRAP ZRANB1 MTIF2

4.65e-05151274int:HSDL2
InteractionCRYZ interactions

ASPM MTIF3 ZRANB1 MTIF2

5.82e-05160274int:CRYZ
InteractionMRPL43 interactions

MTIF3 LTK ZRANB1 MTIF2

6.56e-05165274int:MRPL43
InteractionADGB interactions

IK TRRAP

7.73e-0510272int:ADGB
InteractionMRPS6 interactions

MTIF3 LTK ZRANB1 MTIF2

8.62e-05177274int:MRPS6
InteractionATP5MF-PTCD1 interactions

MTIF3 ZRANB1 MTIF2

1.20e-0472273int:ATP5MF-PTCD1
InteractionMRPL27 interactions

MED24 MTIF3 ZRANB1 MTIF2

1.20e-04193274int:MRPL27
InteractionPPIA interactions

ASPM CACNA1D PTPN23 HEATR5A IK TRRAP ZRANB1

1.29e-04888277int:PPIA
InteractionCTNNBL1 interactions

CRNKL1 IK TRRAP ZRANB1

1.30e-04197274int:CTNNBL1
InteractionZSCAN2 interactions

TRRAP ZRANB1

1.34e-0413272int:ZSCAN2
InteractionPYCR1 interactions

MTIF3 TRRAP ZRANB1 MTIF2

1.46e-04203274int:PYCR1
InteractionMRPL1 interactions

MTIF3 LTK ZRANB1 MTIF2

1.52e-04205274int:MRPL1
InteractionPYCR2 interactions

MTIF3 LTK ZRANB1 MTIF2

1.64e-04209274int:PYCR2
InteractionMRPL24 interactions

MED24 MTIF3 ZRANB1 MTIF2

1.70e-04211274int:MRPL24
InteractionMRPL22 interactions

MED24 MTIF3 ZRANB1 MTIF2

1.79e-04214274int:MRPL22
InteractionMRPL9 interactions

MTIF3 NSF ZRANB1 MTIF2

1.79e-04214274int:MRPL9
InteractionMKI67 interactions

ASPM MED24 DNAH3 IK TRRAP ZRANB1

1.79e-04648276int:MKI67
InteractionMOB2 interactions

TRRAP ZRANB1 ARHGAP11B

2.11e-0487273int:MOB2
InteractionMRPL37 interactions

MTIF3 LTK ZRANB1 MTIF2

2.21e-04226274int:MRPL37
InteractionMRFAP1 interactions

MTIF3 IK ZRANB1

2.41e-0491273int:MRFAP1
InteractionDHRS2 interactions

DNAH3 ZRANB1 MTIF2

2.57e-0493273int:DHRS2
InteractionSPIN4 interactions

TRRAP ZRANB1

2.61e-0418272int:SPIN4
InteractionERAL1 interactions

MTIF3 TRRAP ZRANB1 MTIF2

2.65e-04237274int:ERAL1
InteractionIBA57 interactions

MTIF3 ZRANB1 MTIF2

2.65e-0494273int:IBA57
InteractionLETM1 interactions

MTIF3 TRRAP ZRANB1 MTIF2

2.69e-04238274int:LETM1
InteractionMRPL42 interactions

MED24 MTIF3 ZRANB1 MTIF2

2.86e-04242274int:MRPL42
InteractionCYP27A1 interactions

TRRAP ZRANB1

2.91e-0419272int:CYP27A1
InteractionTTC39B interactions

TRRAP MTIF2

2.91e-0419272int:TTC39B
InteractionCWC27 interactions

HOXC10 TRRAP ZRANB1

3.18e-04100273int:CWC27
InteractionAKR1C1 interactions

TRRAP ZRANB1

3.24e-0420272int:AKR1C1
InteractionMRPL28 interactions

MTIF3 LTK ZRANB1 MTIF2

3.24e-04250274int:MRPL28
InteractionTTI1 interactions

HEATR5A TRRAP ZRANB1

3.27e-04101273int:TTI1
InteractionRAB1B interactions

LTK TRRAP NSF ZRANB1

3.39e-04253274int:RAB1B
CytobandEnsembl 112 genes in cytogenetic band chr10q26

INPP5F ZRANB1

7.58e-03207292chr10q26
GeneFamilyCalcium voltage-gated channel subunits

CACNA1D CACNA1F

4.11e-0426212253
CoexpressionGAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_UP

NSF LEPR SOS1

2.79e-0626283M14024
DrugPl-cs

NSF PLCXD2 MTIF2 SOS1

1.00e-05107294CID006450086
DrugNicotine

ASPM MED24 CACNA1D CACNA1F NSF MTIF2 LEPR SOS1

2.53e-051000298ctd:D009538
Drugpotassium

CACNA1D CACNA1F INPP5F SLC12A1 IK NSF PLCXD2 SOS1

2.68e-051008298CID000000813
DrugCinnarizine

CACNA1D CACNA1F

5.61e-059292DB00568
DrugNimodipine

CACNA1D CACNA1F

5.61e-059292DB00393
Drugisobutanol

CACNA1D IK SOS1

6.68e-0562293CID000006560
Druggallopamil

CACNA1D CACNA1F IK

8.43e-0567293CID000001234
DrugMibefradil

CACNA1D CACNA1F

8.55e-0511292DB01388
DrugNSC759576

CACNA1D CACNA1F TRMT10A SOS1

9.67e-05191294CID000003075
DiseaseTimothy syndrome (implicated_via_orthology)

CACNA1D CACNA1F

4.47e-064262DOID:0060173 (implicated_via_orthology)
DiseaseHearing Loss, Extreme

CACNA1D TMTC2

1.40e-0420262C0086395
DiseaseComplete Hearing Loss

CACNA1D TMTC2

1.40e-0420262C0581883
DiseaseDeaf Mutism

CACNA1D TMTC2

1.40e-0420262C4082305
DiseasePrelingual Deafness

CACNA1D TMTC2

1.40e-0420262C0011052
DiseaseBilateral Deafness

CACNA1D TMTC2

1.40e-0420262C3665473
DiseaseDeafness, Acquired

CACNA1D TMTC2

1.40e-0420262C0751068
DiseasePrimary microcephaly

ASPM TRMT10A

1.71e-0422262C0431350
DiseaseDeafness

CACNA1D TMTC2

2.21e-0425262C0011053
DiseaseDuchenne muscular dystrophy (implicated_via_orthology)

CACNA1D CACNA1F

4.62e-0436262DOID:11723 (implicated_via_orthology)
Diseasefeeling miserable measurement

MED24 NSF

2.21e-0379262EFO_0009598

Protein segments in the cluster

PeptideGeneStartEntry
QQKKWKIMKKAALLI

ASPM

1986

Q8IZT6
WKALKKVNMKLLVNI

ARHGAP11B

246

Q3KRB8
GRIQKDWKKLVQMKI

PTPN23

231

Q9H3S7
RIVIKKIWKRMKQKL

CACNA1F

1551

O60840
VITKAGMKLKWSKLK

MTIF2

141

P46199
LILVKQKKWQGLQEM

LTK

446

P29376
QWIKKKHLVQITIKK

MTIF3

181

Q9H2K0
NKAVKNVIKKLWKQI

OR4C45

286

A6NMZ5
KEKNVTLLWKPLMKN

LEPR

656

P48357
KKVWIGIKKLLMLIE

NSF

701

P46459
LKLLAMAKLWKKQQQ

CRNKL1

816

Q9BZJ0
VKDICQAIWKLKKVM

HEATR5A

376

Q86XA9
WIKNMEKANKLAVIK

DNAH3

3091

Q8TD57
QVKIWFQNRRMKLKK

HOXC10

311

Q9NYD6
MKVNFLKPNLKVNLW

INPP5F

811

Q9Y2H2
VIKKIWKKTSMKLLD

CACNA1D

1576

Q01668
VKVQLMLNQRKWKKR

SYT8

281

Q8NBV8
NVISKSQLKNIKKMW

NARS1

56

O43776
MKVVNLKQAILQAWK

MED24

1

O75448
GMAKKQAWLIKNKIK

SLC12A1

731

Q13621
MKKWVESITKIIQRK

SOS1

726

Q07889
LIQMKSIWKKKQKNQ

TRIM77

141

I1YAP6
LARISLVKKLMKKWS

PLCXD2

81

Q0VAA5
LVKKLMKKWSVTQNL

PLCXD2

86

Q0VAA5
KLWNIMEKQGLKTSK

TMTC2

821

Q8N394
QWKKISAIIEKRKKM

IK

531

Q13123
SKRQMKKLIKQKQWE

TRMT10A

41

Q8TBZ6
SMKLHNLISKLKKWI

TRRAP

3431

Q9Y4A5
LKKWIKILEAKTKQL

TRRAP

3441

Q9Y4A5
KLKQIKNRMKKTDWL

ZRANB1

251

Q9UGI0
ILIIAAKWLQKMKEK

MYMK

126

A6NI61