Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessembryonic digit morphogenesis

HOXA11 FREM2 TBX3 HOXC11 HOXD11 TBX2

3.69e-0974376GO:0042733
GeneOntologyBiologicalProcessembryonic limb morphogenesis

HOXA11 FREM2 TBX3 HOXC11 HOXD11 TBX2

2.39e-07148376GO:0030326
GeneOntologyBiologicalProcessembryonic appendage morphogenesis

HOXA11 FREM2 TBX3 HOXC11 HOXD11 TBX2

2.39e-07148376GO:0035113
GeneOntologyBiologicalProcessappendage morphogenesis

HOXA11 FREM2 TBX3 HOXC11 HOXD11 TBX2

8.86e-07185376GO:0035107
GeneOntologyBiologicalProcesslimb morphogenesis

HOXA11 FREM2 TBX3 HOXC11 HOXD11 TBX2

8.86e-07185376GO:0035108
GeneOntologyBiologicalProcessembryonic skeletal joint morphogenesis

HOXA11 HOXC11 HOXD11

1.50e-0613373GO:0060272
GeneOntologyBiologicalProcessatrioventricular canal development

TBX3 FOXN4 TBX2

1.91e-0614373GO:0036302
GeneOntologyBiologicalProcesslimb development

HOXA11 FREM2 TBX3 HOXC11 HOXD11 TBX2

2.69e-06224376GO:0060173
GeneOntologyBiologicalProcessappendage development

HOXA11 FREM2 TBX3 HOXC11 HOXD11 TBX2

2.69e-06224376GO:0048736
GeneOntologyBiologicalProcessembryonic skeletal joint development

HOXA11 HOXC11 HOXD11

3.55e-0617373GO:0072498
GeneOntologyBiologicalProcessureteric peristalsis

TBX3 TBX2

9.38e-063372GO:0072105
GeneOntologyBiologicalProcesspositive regulation of chondrocyte development

HOXA11 HOXD11

9.38e-063372GO:1902761
GeneOntologyBiologicalProcessureter smooth muscle contraction

TBX3 TBX2

9.38e-063372GO:0014849
GeneOntologyBiologicalProcessorgan induction

HOXA11 HOXC11 HOXD11

1.34e-0526373GO:0001759
GeneOntologyBiologicalProcessmammary placode formation

TBX3 TBX2

1.87e-054372GO:0060596
GeneOntologyBiologicalProcessregionalization

HOXA11 TBX3 TDRD6 HOXC11 HOXD11 FOXN4 TBX2

1.94e-05478377GO:0003002
GeneOntologyBiologicalProcessregulation of animal organ formation

HOXA11 HOXC11 HOXD11

2.54e-0532373GO:0003156
GeneOntologyBiologicalProcessatrioventricular canal morphogenesis

TBX3 TBX2

3.12e-055372GO:1905222
GeneOntologyBiologicalProcessembryonic organ morphogenesis

HOXA11 TBX3 HOXC11 HOXD11 FOXN4 TBX2

3.47e-05351376GO:0048562
GeneOntologyBiologicalProcesspattern specification process

HOXA11 TBX3 TDRD6 HOXC11 HOXD11 FOXN4 TBX2

3.57e-05526377GO:0007389
GeneOntologyBiologicalProcessanatomical structure formation involved in morphogenesis

FZD8 HOXA11 CACNA1S TBX3 ABCA2 KLK4 HOXC11 HOXD11 FOXN4 LPA TBX2

3.81e-0514833711GO:0048646
GeneOntologyBiologicalProcessproximal/distal pattern formation

HOXA11 HOXC11 HOXD11

3.96e-0537373GO:0009954
GeneOntologyBiologicalProcessembryonic forelimb morphogenesis

HOXA11 TBX3 HOXD11

3.96e-0537373GO:0035115
GeneOntologyBiologicalProcesscardiac jelly development

TBX3 TBX2

4.68e-056372GO:1905072
GeneOntologyBiologicalProcessembryonic organ development

HOXA11 TBX3 HOXC11 HOXD11 FOXN4 LPA TBX2

5.37e-05561377GO:0048568
GeneOntologyBiologicalProcessspecification of animal organ identity

HOXA11 HOXC11 HOXD11

5.40e-0541373GO:0010092
GeneOntologyBiologicalProcesspositive regulation of animal organ morphogenesis

HOXA11 HOXC11 HOXD11

5.40e-0541373GO:0110110
GeneOntologyBiologicalProcessdevelopmental induction

HOXA11 HOXC11 HOXD11

5.40e-0541373GO:0031128
GeneOntologyBiologicalProcessanterior/posterior pattern specification

HOXA11 TBX3 TDRD6 HOXC11 HOXD11

7.54e-05247375GO:0009952
GeneOntologyBiologicalProcessforelimb morphogenesis

HOXA11 TBX3 HOXD11

8.69e-0548373GO:0035136
GeneOntologyBiologicalProcessregulation of chondrocyte development

HOXA11 HOXD11

8.71e-058372GO:0061181
GeneOntologyBiologicalProcessmammary gland formation

TBX3 TBX2

1.12e-049372GO:0060592
GeneOntologyBiologicalProcessembryonic morphogenesis

HOXA11 FREM2 TBX3 HOXC11 HOXD11 FOXN4 TBX2

2.38e-04713377GO:0048598
GeneOntologyBiologicalProcessheart looping

TBX3 FOXN4 TBX2

3.03e-0473373GO:0001947
GeneOntologyBiologicalProcessurinary tract smooth muscle contraction

TBX3 TBX2

3.24e-0415372GO:0014848
GeneOntologyBiologicalProcessperistalsis

TBX3 TBX2

3.24e-0415372GO:0030432
GeneOntologyBiologicalProcessanimal organ formation

HOXA11 HOXC11 HOXD11

3.68e-0478373GO:0048645
GeneOntologyBiologicalProcessectodermal placode morphogenesis

TBX3 TBX2

3.70e-0416372GO:0071697
GeneOntologyBiologicalProcessectodermal placode formation

TBX3 TBX2

3.70e-0416372GO:0060788
GeneOntologyBiologicalProcessdetermination of heart left/right asymmetry

TBX3 FOXN4 TBX2

3.83e-0479373GO:0061371
GeneOntologyBiologicalProcessembryonic heart tube morphogenesis

TBX3 FOXN4 TBX2

3.97e-0480373GO:0003143
GeneOntologyBiologicalProcessbranching morphogenesis of an epithelial tube

HOXA11 TBX3 HOXD11 TBX2

4.25e-04198374GO:0048754
GeneOntologyBiologicalProcessectodermal placode development

TBX3 TBX2

4.70e-0418372GO:0071696
GeneOntologyBiologicalProcessmuscle cell fate commitment

TBX3 TBX2

4.70e-0418372GO:0042693
GeneOntologyBiologicalProcessmetanephros development

HOXA11 HOXC11 HOXD11

6.57e-0495373GO:0001656
GeneOntologyBiologicalProcessmorphogenesis of an epithelium

HOXA11 FREM2 TBX3 HOXD11 FOXN4 TBX2

7.50e-04619376GO:0002009
GeneOntologyBiologicalProcessembryo development

HOXA11 FREM2 TBX3 TDRD6 HOXC11 HOXD11 FOXN4 LPA TBX2

7.89e-041437379GO:0009790
GeneOntologyBiologicalProcessmorphogenesis of a branching epithelium

HOXA11 TBX3 HOXD11 TBX2

8.20e-04236374GO:0061138
GeneOntologyBiologicalProcessembryonic heart tube development

TBX3 FOXN4 TBX2

8.31e-04103373GO:0035050
GeneOntologyBiologicalProcessanterior/posterior axis specification, embryo

TBX3 TDRD6

8.43e-0424372GO:0008595
GeneOntologyBiologicalProcesstripartite regional subdivision

TBX3 TDRD6

8.43e-0424372GO:0007351
GeneOntologyBiologicalProcesspositive regulation of chondrocyte differentiation

HOXA11 HOXD11

8.43e-0424372GO:0032332
GeneOntologyBiologicalProcessepithelial tube morphogenesis

HOXA11 TBX3 HOXD11 FOXN4 TBX2

8.80e-04421375GO:0060562
GeneOntologyBiologicalProcessregulation of steroid biosynthetic process

HSD3B1 ABCA2 CYP7A1

9.03e-04106373GO:0050810
GeneOntologyBiologicalProcessdorsal/ventral pattern formation

HOXA11 HOXD11 FOXN4

9.28e-04107373GO:0009953
GeneOntologyBiologicalProcessembryonic skeletal system morphogenesis

HOXA11 HOXC11 HOXD11

9.79e-04109373GO:0048704
GeneOntologyBiologicalProcessregulation of animal organ morphogenesis

HOXA11 HOXC11 HOXD11

1.00e-03110373GO:2000027
GeneOntologyBiologicalProcessresponse to ketone

HOXA11 HSD3B1 PTGDR TBX2

1.08e-03254374GO:1901654
GeneOntologyBiologicalProcessmorphogenesis of a branching structure

HOXA11 TBX3 HOXD11 TBX2

1.14e-03258374GO:0001763
GeneOntologyBiologicalProcessphasic smooth muscle contraction

TBX3 TBX2

1.32e-0330372GO:0014821
GeneOntologyBiologicalProcesscell fate specification

HOXA11 TBX3 TBX2

1.39e-03123373GO:0001708
GeneOntologyBiologicalProcessendocardial cushion formation

TBX3 TBX2

1.50e-0332372GO:0003272
GeneOntologyBiologicalProcesscellular senescence

TBX3 MAPKAPK5 TBX2

1.55e-03128373GO:0090398
GeneOntologyBiologicalProcessregulation of cholesterol biosynthetic process

ABCA2 CYP7A1

1.60e-0333372GO:0045540
GeneOntologyBiologicalProcessregulation of sterol biosynthetic process

ABCA2 CYP7A1

1.60e-0333372GO:0106118
GeneOntologyBiologicalProcessblastoderm segmentation

TBX3 TDRD6

1.79e-0335372GO:0007350
GeneOntologyBiologicalProcessregulation of steroid metabolic process

HSD3B1 ABCA2 CYP7A1

1.81e-03135373GO:0019218
GeneOntologyBiologicalProcessmyoblast differentiation

TBX3 LPA TBX2

1.85e-03136373GO:0045445
GeneOntologyBiologicalProcesspositive regulation of cartilage development

HOXA11 HOXD11

1.90e-0336372GO:0061036
GeneOntologyBiologicalProcesstissue morphogenesis

HOXA11 FREM2 TBX3 HOXD11 FOXN4 TBX2

2.01e-03750376GO:0048729
GeneOntologyBiologicalProcessembryonic skeletal system development

HOXA11 HOXC11 HOXD11

2.35e-03148373GO:0048706
GeneOntologyBiologicalProcesschondrocyte development

HOXA11 HOXD11

2.46e-0341372GO:0002063
GeneOntologyBiologicalProcessdetermination of left/right symmetry

TBX3 FOXN4 TBX2

2.63e-03154373GO:0007368
GeneOntologyBiologicalProcessendocardial cushion morphogenesis

TBX3 TBX2

2.82e-0344372GO:0003203
GeneOntologyBiologicalProcesstube development

FZD8 HOXA11 TBX3 HOXD11 FOXN4 LPA ADAM7 TBX2

2.92e-031402378GO:0035295
GeneOntologyBiologicalProcessleft/right pattern formation

TBX3 FOXN4 TBX2

3.04e-03162373GO:0060972
GeneOntologyBiologicalProcesscell fate commitment

HOXA11 TBX3 FOXN4 TBX2

3.05e-03338374GO:0045165
GeneOntologyBiologicalProcessdetermination of bilateral symmetry

TBX3 FOXN4 TBX2

3.20e-03165373GO:0009855
GeneOntologyBiologicalProcessspecification of symmetry

TBX3 FOXN4 TBX2

3.20e-03165373GO:0009799
GeneOntologyBiologicalProcesscartilage development involved in endochondral bone morphogenesis

HOXA11 HOXD11

3.22e-0347372GO:0060351
GeneOntologyBiologicalProcesstube morphogenesis

FZD8 HOXA11 TBX3 HOXD11 FOXN4 LPA TBX2

3.44e-031125377GO:0035239
MousePhenoincreased cardiac muscle contractility

FZD8 TBX3 CSNK1G2 ADAM7

1.18e-0569294MP:0005599
MousePhenoincreased lumbar vertebrae number

HOXA11 HOXD11

2.49e-054292MP:0004650
MousePhenoabnormal carpal bone morphology

HOXA11 TBX3 HOXD11

5.47e-0536293MP:0000554
DomainDUF3528

HOXA11 HOXC11 HOXD11

7.77e-093383PF12045
DomainDUF3528

HOXA11 HOXC11 HOXD11

7.77e-093383IPR021918
DomainTBX

TBX3 TBX2

4.03e-062382IPR022582
DomainTBX

TBX3 TBX2

4.03e-062382PF12598
DomainTF_T-box

TBX3 TBX2

5.38e-0417382IPR001699
DomainTBOX_3

TBX3 TBX2

5.38e-0417382PS50252
DomainTBOX

TBX3 TBX2

5.38e-0417382SM00425
DomainTF_T-box_CS

TBX3 TBX2

5.38e-0417382IPR018186
DomainT-box

TBX3 TBX2

5.38e-0417382PF00907
Domain-

TBX3 TBX2

5.38e-04173822.60.40.820
DomainTBOX_1

TBX3 TBX2

5.38e-0417382PS01283
DomainTBOX_2

TBX3 TBX2

5.38e-0417382PS01264
DomainHomeobox_metazoa

HOXA11 HOXC11 HOXD11

8.08e-0490383IPR020479
DomainKinase-like_dom

NEK3 ACAD10 MAPKAPK5 CSNK1G2 SGK3

4.60e-03542385IPR011009
Domainp53-like_TF_DNA-bd

TBX3 TBX2

5.20e-0353382IPR008967
DomainSer/Thr_kinase_AS

NEK3 MAPKAPK5 CSNK1G2 SGK3

5.80e-03357384IPR008271
DomainS_TKc

NEK3 MAPKAPK5 CSNK1G2 SGK3

5.92e-03359384SM00220
DomainPROTEIN_KINASE_ST

NEK3 MAPKAPK5 CSNK1G2 SGK3

6.09e-03362384PS00108
DomainHomeobox_CS

HOXA11 HOXC11 HOXD11

6.35e-03186383IPR017970
DomainPkinase

NEK3 MAPKAPK5 CSNK1G2 SGK3

7.28e-03381384PF00069
PathwayREACTOME_FORMATION_OF_THE_URETERIC_BUD

HOXA11 HOXC11 HOXD11

1.25e-0521313M48244
PathwayREACTOME_KIDNEY_DEVELOPMENT

HOXA11 HOXC11 HOXD11

1.37e-0446313M48243
PathwayWP_DEVELOPMENT_OF_URETERIC_COLLECTION_SYSTEM

HOXA11 FREM2 HOXD11

3.03e-0460313M40048
Pubmed

Generation and expression of a Hoxa11eGFP targeted allele in mice.

HOXA11 HOXC11 HOXD11

1.30e-08539318942146
Pubmed

Hox11 expression characterizes developing zeugopod synovial joints and is coupled to postnatal articular cartilage morphogenesis into functional zones in mice.

HOXA11 HOXC11 HOXD11

1.30e-08539334010606
Pubmed

The formation of the thumb requires direct modulation of Gli3 transcription by Hoxa13.

HOXA11 TBX3 HOXD11 TBX2

1.41e-082439431896583
Pubmed

Non-homeodomain regions of Hox proteins mediate activation versus repression of Six2 via a single enhancer site in vivo.

HOXA11 HOXC11 HOXD11

4.55e-08739319716816
Pubmed

Hox11 genes establish synovial joint organization and phylogenetic characteristics in developing mouse zeugopod skeletal elements.

HOXA11 HOXC11 HOXD11

7.27e-08839320978074
Pubmed

Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton.

HOXA11 HOXC11 HOXD11

7.27e-08839312869760
Pubmed

Hox11 paralogous genes are essential for metanephric kidney induction.

HOXA11 HOXC11 HOXD11

7.27e-08839312050119
Pubmed

Tetrapod axial evolution and developmental constraints; Empirical underpinning by a mouse model.

HOXA11 HOXC11 HOXD11

7.27e-08839326238020
Pubmed

Targeted disruption of Hotair leads to homeotic transformation and gene derepression.

HOXA11 HOXC11 HOXD11

1.56e-071039324075995
Pubmed

Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo.

HOXA11 HOXC11 HOXD11

4.70e-071439318485340
Pubmed

Hoxa11 and Hoxd11 regulate branching morphogenesis of the ureteric bud in the developing kidney.

HOXA11 HOXC11 HOXD11

4.70e-071439311493536
Pubmed

The mouse Ulnaless mutation deregulates posterior HoxD gene expression and alters appendicular patterning.

HOXA11 HOXC11 HOXD11

4.70e-07143939342041
Pubmed

Twist1 activity thresholds define multiple functions in limb development.

TBX3 HOXD11 TBX2

5.88e-071539320732316
Pubmed

Distal Limb Patterning Requires Modulation of cis-Regulatory Activities by HOX13.

HOXA11 HOXC11 HOXD11

7.23e-071639327974206
Pubmed

A Hox Code Defines Spinocerebellar Neuron Subtype Regionalization.

HOXA11 HOXC11 HOXD11

7.23e-071639331747609
Pubmed

Hox patterning of the vertebrate rib cage.

HOXA11 HOXC11 HOXD11

8.77e-071739317626057
Pubmed

Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development.

TBX3 HOXD11 TBX2

1.05e-061839320386744
Pubmed

Complex functional redundancy of Tbx2 and Tbx3 in mouse limb development.

TBX3 TBX2

1.23e-06239235506352
Pubmed

The T-box transcription factors TBX2 and TBX3 in mammary gland development and breast cancer.

TBX3 TBX2

1.23e-06239223624936
Pubmed

The transcription factors TBX2 and TBX3 interact with human papillomavirus 16 (HPV16) L2 and repress the long control region of HPVs.

TBX3 TBX2

1.23e-06239223388722
Pubmed

Identification of TBX2 and TBX3 variants in patients with conotruncal heart defects by target sequencing.

TBX3 TBX2

1.23e-06239230223900
Pubmed

Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome.

TBX3 TBX2

1.23e-06239210468588
Pubmed

Absence of mutations in the HOXA11 and HOXD11 genes in children with congenital renal malformations.

HOXA11 HOXD11

1.23e-06239219255789
Pubmed

Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11.

HOXA11 HOXD11

1.23e-0623927596412
Pubmed

Comprehensive microarray analysis of Hoxa11/Hoxd11 mutant kidney development.

HOXA11 HOXD11

1.23e-06239216581055
Pubmed

Functional equivalence and rescue among group 11 Hox gene products in vertebral patterning.

HOXA11 HOXD11

1.23e-0623928660870
Pubmed

Stratification based on methylation of TBX2 and TBX3 into three molecular grades predicts progression in patients with pTa-bladder cancer.

TBX3 TBX2

1.23e-06239225394776
Pubmed

The anti-proliferative function of the TGF-β1 signaling pathway involves the repression of the oncogenic TBX2 by its homologue TBX3.

TBX3 TBX2

1.23e-06239225371204
Pubmed

Hox10 genes function in kidney development in the differentiation and integration of the cortical stroma.

HOXA11 HOXC11 HOXD11

1.25e-061939321858105
Pubmed

FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis.

TBX3 HOXD11 TBX2

1.71e-062139316207751
Pubmed

Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs.

HOXA11 HOXC11 HOXD11

1.98e-062239326283362
Pubmed

TBX3 is essential for establishment of the posterior boundary of anterior genes and upregulation of posterior genes together with HAND2 during the onset of limb bud development.

TBX3 HOXD11 TBX2

2.27e-062339338828908
Pubmed

Expression of Drosophila omb-related T-box genes in the developing human and mouse neural retina.

TBX3 TBX2

3.67e-06339211726608
Pubmed

T-box family reunion.

TBX3 TBX2

3.67e-0633929196325
Pubmed

Functional specificity of the Hoxa13 homeobox.

HOXA11 HOXD11

3.67e-06339211688568
Pubmed

Chromatoid Body Protein TDRD6 Supports Long 3' UTR Triggered Nonsense Mediated mRNA Decay.

TDRD6 UPF2

3.67e-06339227149095
Pubmed

Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes.

TBX3 TBX2

3.67e-06339220025935
Pubmed

Deletion of a HoxD enhancer induces transcriptional heterochrony leading to transposition of the sacrum.

HOXA11 HOXD11

3.67e-0633929250683
Pubmed

Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family.

TBX3 TBX2

3.67e-0633928988164
Pubmed

The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator.

TBX3 TBX2

3.67e-06339212000749
Pubmed

Nonsense in the testis: multiple roles for nonsense-mediated decay revealed in male reproduction.

TDRD6 UPF2

3.67e-06339228444146
Pubmed

Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher.

GALC PTGDR

3.67e-06339216624958
Pubmed

TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.

TBX3 TBX2

3.67e-06339211748239
Pubmed

The mouse Hoxc11 gene: genomic structure and expression pattern.

HOXC11 HOXD11

3.67e-0633929510030
Pubmed

The human HOX gene family.

HOXA11 HOXC11 HOXD11

4.67e-06293932574852
Pubmed

Ndrg2 regulates vertebral specification in differentiating somites.

HOXA11 HOXC11 HOXD11

6.32e-063239322819676
Pubmed

Hoxa 11 is upstream of Integrin alpha8 expression in the developing kidney.

HOXA11 HOXD11

7.34e-06439212060755
Pubmed

Tbx3 represses E-cadherin expression and enhances melanoma invasiveness.

TBX3 TBX2

7.34e-06439218829543
Pubmed

Genome-wide analysis of CpG island methylation in bladder cancer identified TBX2, TBX3, GATA2, and ZIC4 as pTa-specific prognostic markers.

TBX3 TBX2

7.34e-06439222284968
Pubmed

Evidence of a role for T-box genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity.

TBX3 TBX2

7.34e-0643928798150
Pubmed

Atlas of Hox gene expression in the developing kidney.

HOXA11 HOXC11 HOXD11

1.07e-053839315042701
Pubmed

Complete mutation analysis panel of the 39 human HOX genes.

HOXA11 HOXC11 HOXD11

1.07e-053839311857506
Pubmed

Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster.

HOXA11 HOXC11 HOXD11

1.16e-053939333257809
Pubmed

Altered Hox expression and increased cell death distinguish Hypodactyly from Hoxa13 null mice.

HOXA11 HOXD11

1.22e-05539210470645
Pubmed

Genetic analysis of a Hoxd-12 regulatory element reveals global versus local modes of controls in the HoxD complex.

HOXA11 HOXD11

1.22e-0553929521905
Pubmed

The level of BMP4 signaling is critical for the regulation of distinct T-box gene expression domains and growth along the dorso-ventral axis of the optic cup.

TBX3 TBX2

1.22e-05539217173667
Pubmed

A Hox-Eya-Pax complex regulates early kidney developmental gene expression.

HOXA11 HOXD11

1.22e-05539217785448
Pubmed

Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development.

TBX3 TBX2

1.22e-0553928853987
Pubmed

Regulation of number and size of digits by posterior Hox genes: a dose-dependent mechanism with potential evolutionary implications.

HOXA11 HOXD11

1.22e-0553929391088
Pubmed

Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence.

TBX3 TBX2

1.22e-05539222002537
Pubmed

Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis.

TBX3 TBX2

1.22e-0553921375456
Pubmed

Duplication of the Hoxd11 gene causes alterations in the axial and appendicular skeleton of the mouse.

HOXA11 HOXD11

1.22e-05539212217321
Pubmed

Quantification of Hox and surfactant protein-B transcription during murine lung development.

HOXA11 HOXC11 HOXD11

1.25e-054039319204410
Pubmed

Reduction of Hox gene expression by histone H1 depletion.

HOXA11 HOXC11 HOXD11

1.56e-054339322701719
Pubmed

Nomenclature for human homeobox genes.

HOXA11 HOXC11 HOXD11

1.67e-05443931973146
Pubmed

Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway.

TBX3 TBX2

1.83e-05639216222716
Pubmed

Reduced sodium channel function unmasks residual embryonic slow conduction in the adult right ventricular outflow tract.

TBX3 TBX2

1.83e-05639223661717
Pubmed

Lack of genetic interaction between Tbx20 and Tbx3 in early mouse heart development.

TBX3 TBX2

1.83e-05639223936153
Pubmed

Genetic analysis of a conserved sequence in the HoxD complex: regulatory redundancy or limitations of the transgenic approach?

HOXA11 HOXD11

1.83e-0563929733096
Pubmed

Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud.

TBX3 TBX2

1.83e-05639218410737
Pubmed

Evolution of mouse T-box genes by tandem duplication and cluster dispersion.

TBX3 TBX2

1.83e-0563928878690
Pubmed

Hotair Is Dispensible for Mouse Development.

HOXC11 HOXD11

1.83e-05639227977683
Pubmed

Excess of ovarian nerve growth factor impairs embryonic development and causes reproductive and metabolic dysfunction in adult female mice.

HSD3B1 MAOA TET3

2.04e-054739332892421
Pubmed

Vertebrate homeobox gene nomenclature.

HOXA11 HOXC11 HOXD11

2.04e-05473931358459
Pubmed

Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly.

FZD8 FREM2 TBX3

2.32e-054939321795542
Pubmed

New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice.

HOXA11 HOXC11 HOXD11

2.46e-055039328188179
Pubmed

Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis.

TBX3 TBX2

2.56e-05739222203979
Pubmed

Choline kinase beta is required for normal endochondral bone formation.

HOXA11 HOXD11

2.56e-05739224637075
Pubmed

Expression of Tbx2 and Tbx3 in the developing hypothalamic-pituitary axis.

TBX3 TBX2

2.56e-05739218534921
Pubmed

Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field.

TBX3 TBX2

2.56e-05739216556915
Pubmed

Mesomelic dysplasias associated with the HOXD locus are caused by regulatory reallocations.

HOXA11 HOXD11

2.56e-05739234408147
Pubmed

Genetic interaction of Gli3 and Alx4 during limb development.

HOXA11 HOXD11

2.56e-05739215968591
Pubmed

Dynamic expression of Tbx2 and Tbx3 in developing mouse pancreas.

TBX3 TBX2

3.42e-05839221867776
Pubmed

A combined analysis of genomic and primary protein structure defines the phylogenetic relationship of new members if the T-box family.

TBX3 TBX2

3.42e-0583929503012
Pubmed

AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins.

HOXA11 HOXD11

3.42e-0583929343407
Pubmed

An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus.

TBX3 TBX2

3.42e-0583927920656
Pubmed

Bone morphology is regulated modularly by global and regional genetic programs.

HOXA11 HOXD11

4.39e-05939231221640
Pubmed

Reshuffling genomic landscapes to study the regulatory evolution of Hox gene clusters.

HOXC11 HOXD11

4.39e-05939221670281
Pubmed

Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod.

HOXA11 HOXD11

4.39e-05939214668414
Pubmed

"Self-regulation," a new facet of Hox genes' function.

HOXA11 HOXD11

4.39e-05939223913823
Pubmed

Dynamic expression of Tbx2 subfamily genes in development of the mouse reproductive system.

TBX3 TBX2

5.48e-051039222223620
Pubmed

Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43.

TBX3 TBX2

5.48e-051039218285513
Pubmed

Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis.

TBX3 TBX2

5.48e-051039217519333
Pubmed

MyoR modulates cardiac conduction by repressing Gata4.

TBX3 TBX2

5.48e-051039225487574
Pubmed

Structural and functional differences in the long non-coding RNA hotair in mouse and human.

HOXC11 HOXD11

5.48e-051039221637793
Pubmed

Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3.

HOXD11 TBX2

5.48e-051039222841643
Pubmed

High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.

HOXA11 TBX3 HSD3B1 HOXD11 TBX2

6.68e-0538339519453261
Pubmed

Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy.

TBX3 TBX2

6.70e-051139217668378
Pubmed

Recombineering-based dissection of flanking and paralogous Hox gene functions in mouse reproductive tracts.

HOXA11 HOXD11

6.70e-051139223760953
Pubmed

Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling.

TBX3 TBX2

6.70e-051139214723846
CytobandEnsembl 112 genes in cytogenetic band chr12q24

TBX3 ACAD10 MAPKAPK5 FOXN4

4.21e-04415394chr12q24
GeneFamilyHOXL subclass homeoboxes

HOXA11 HOXC11 HOXD11

6.25e-0552273518
GeneFamilyT-boxes

TBX3 TBX2

3.24e-0418272766
ComputationalGenes in the cancer module 470.

ABCA2 MAOA

4.29e-0416212MODULE_470
DiseaseLimb Deformities, Congenital

HOXA11 TBX3 HOXD11

1.22e-0617373C0206762
Diseasecarbohydrate intake measurement

ACAD10 MAPKAPK5

8.37e-0434372EFO_0010811
Diseaseaspirin use measurement

ACAD10 LPA

1.10e-0339372EFO_0007013
DiseaseHypercholesterolemia

CYP7A1 LPA

1.10e-0339372C0020443
Diseaseblood copper measurement

ACAD10 MAPKAPK5

1.80e-0350372EFO_0007578
DiseaseAcute Cerebrovascular Accidents

TBX3 LPA

2.10e-0354372C0751956
DiseaseCerebrovascular accident

TBX3 LPA

2.76e-0362372C0038454
Diseaselow density lipoprotein cholesterol measurement, physical activity

CYP7A1 LPA

3.12e-0366372EFO_0003940, EFO_0004611

Protein segments in the cluster

PeptideGeneStartEntry
YYYGMPFTLVDSCWP

ARSF

161

P54793
DRMQCESPPVYSGYY

ELFN1

216

P0C7U0
YTCALRPMYIYGEGS

HSD3B1

181

P14060
QGISYPGGMCLPYYS

ADAM7

301

Q9H2U9
YVMEYCPGLIYKDPS

ACAD10

361

Q6JQN1
MCSLPVIYRAYYGAF

PTGDR

276

Q13258
LYDPLYHPSMFCAGG

KLK4

181

Q9Y5K2
CYTAYFPPGIMTQYG

MAOA

406

P21397
YYGPLAFMYMGSASP

OR5H14

251

A6NHG9
IYVMLCGYPPFYSKH

MAPKAPK5

231

Q8IW41
PYEVCMKGIPYIAAY

MFHAS1

381

Q9Y4C4
YVPKYSPMNAEYGCL

FREM2

2926

Q5SZK8
YYFGPCGKYNAMVLE

CSNK1G2

106

P78368
FLCYDPYSGDIYTMP

KBTBD7

356

Q8WVZ9
SNMYLPSCTYYVSGP

HOXA11

11

P31270
YSLGCAFPYAAYSMP

PAQR6

126

Q6TCH4
MAFACTYVGTPYYVP

NEK3

156

P51956
PLCKGIGYNYTYMPN

FZD8

41

Q9H461
AYGGPSYPGMLVCIY

CACNA1S

626

Q13698
AASMYLPGCAYYVAP

HOXD11

11

P31277
EPGSYVQMFPYPCYT

ABCA2

681

Q9BZC7
TPEYYPNAGLIMNYC

LPA

291

P08519
TPEYYPNAGLIMNYC

LPA

861

P08519
NLYLPSCTYYMPEFS

HOXC11

31

O43248
MTRYFCCGSYFPGYP

KRTAP7-1

1

Q8IUC3
KYYYMPFGSGATICP

CYP7A1

431

P22680
ASYYEQLPYGRCGLM

GALC

311

P54803
KGMYSCPCYYYPNRA

DNAH2

4376

Q9P225
YGLPPFYCRDVAEMY

SGK3

356

Q96BR1
TMVENAYYYCNPPPA

UPF2

746

Q9HAU5
YPKPIYSYSCLIAMA

FOXN4

191

Q96NZ1
YFRMPVVTYPCALYG

TDRD6

366

O60522
FPYPYTYMAAAAAAS

TBX3

601

O15119
CSEPGSYFPYKHSYM

SHISAL2B

46

A6NKW6
ELCPGYSNPNYMYLA

RMDN2

351

Q96LZ7
GLFPYPYTYMAAAAA

TBX2

571

Q13207
YCLRGMDYYASGAPC

SMRP1

206

Q8NCR6
CRPSDPYSMNSVYSY

TET3

1246

O43151
GYFGPKCYMILFYPE

TAS1R2

806

Q8TE23
PVPYLYFDMGAAVLC

TMEM101

51

Q96IK0
YRGDIYFCTGYDPPM

HEBP1

161

Q9NRV9