| GeneOntologyMolecularFunction | DNA-binding transcription factor activity, RNA polymerase II-specific | ZNF599 FOXN1 ZNF793 ZNF383 TSHZ3 ZNF676 ZNF211 ZNF146 ZNF585A ZNF670 ZNF559 ZNF674 ZNF846 ZNF329 ZNF506 ISL2 ZNF480 ZNF208 ZNF215 ZNF615 ISL1 ZNF723 ZNF227 ZNF112 ZNF91 USF2 ZNF850 ZNF416 ZNF879 NOTCH1 ZBTB14 ZNF260 ZNF345 ZNF71 ZNF585B ZNF445 ZNF707 | 4.33e-22 | 1412 | 79 | 37 | GO:0000981 |
| GeneOntologyMolecularFunction | RNA polymerase II transcription regulatory region sequence-specific DNA binding | ZNF599 ZNF793 ZNF383 ZNF671 ZNF676 ZNF211 ZNF146 ZNF585A ZNF670 ZNF559 ZNF674 ZNF846 ZNF329 NSD1 ZNF506 ZNF480 ZNF208 ZNF215 ZNF615 ISL1 ZNF723 ZNF227 ZNF112 ZNF91 USF2 ZNF850 ZNF416 ZNF879 ZBTB14 ZNF260 ZNF345 ZNF71 ZNF585B ZNF445 ZNF707 | 1.59e-19 | 1459 | 79 | 35 | GO:0000977 |
| GeneOntologyMolecularFunction | cis-regulatory region sequence-specific DNA binding | ZNF793 ZNF383 ZNF671 ZNF676 ZNF211 ZNF146 ZNF585A ZNF670 NSD1 ZNF506 ISL2 ZNF480 ZNF208 ZNF215 ZNF615 ISL1 ZNF723 ZNF227 ZNF112 ZNF91 USF2 ZNF850 ZNF416 ZNF879 NOTCH1 ZBTB14 ZNF260 ZNF345 ZNF71 ZNF585B ZNF445 ZNF707 | 2.58e-18 | 1271 | 79 | 32 | GO:0000987 |
| GeneOntologyMolecularFunction | RNA polymerase II cis-regulatory region sequence-specific DNA binding | ZNF793 ZNF383 ZNF671 ZNF676 ZNF211 ZNF146 ZNF585A ZNF670 NSD1 ZNF506 ZNF480 ZNF208 ZNF215 ZNF615 ISL1 ZNF723 ZNF227 ZNF112 ZNF91 USF2 ZNF850 ZNF416 ZNF879 ZBTB14 ZNF260 ZNF345 ZNF71 ZNF585B ZNF445 ZNF707 | 1.39e-16 | 1244 | 79 | 30 | GO:0000978 |
| GeneOntologyMolecularFunction | DNA-binding transcription activator activity, RNA polymerase II-specific | FOXN1 ZNF585A ZNF208 ZNF615 ISL1 ZNF227 ZNF112 ZNF91 ZNF850 NOTCH1 ZNF345 ZNF71 ZNF585B ZNF445 | 3.69e-08 | 560 | 79 | 14 | GO:0001228 |
| GeneOntologyMolecularFunction | DNA-binding transcription activator activity | FOXN1 ZNF585A ZNF208 ZNF615 ISL1 ZNF227 ZNF112 ZNF91 ZNF850 NOTCH1 ZNF345 ZNF71 ZNF585B ZNF445 | 4.21e-08 | 566 | 79 | 14 | GO:0001216 |
| GeneOntologyMolecularFunction | zinc ion binding | BLM TCEA3 ZNF146 ADAMTS15 NSD1 ZNF208 POLR1B ZNF214 ZNF91 CHORDC1 TRIP12 | 7.39e-04 | 891 | 79 | 11 | GO:0008270 |
| GeneOntologyBiologicalProcess | positive regulation of transcription by RNA polymerase II | FOXN1 ZNF585A RRP1B ISL2 ZNF208 ZNF615 ISL1 ZNF227 ZNF112 ZNF91 USF2 ZNF850 NOTCH1 ZNF345 ZNF71 ZNF585B ZNF445 | 1.93e-05 | 1390 | 80 | 17 | GO:0045944 |
| GeneOntologyBiologicalProcess | visceral motor neuron differentiation | ISL2 ISL1 | 4.45e-05 | 3 | 80 | 2 | GO:0021524 |
| Domain | zf-C2H2 | ZNF599 ZNF793 ZNF383 TSHZ3 ZNF671 ZNF676 ZNF211 ZNF146 ZNF585A ZNF670 ZNF559 ZNF674 ZNF846 ZNF329 ZNF506 ZNF480 ZNF208 ZNF214 ZNF215 ZNF615 ZNF227 ZNF112 ZNF91 ZNF850 ZNF416 ZNF879 ZBTB14 ZNF260 ZNF345 ZNF71 ZNF585B ZNF445 ZNF707 | 3.96e-27 | 693 | 77 | 33 | PF00096 |
| Domain | - | ZNF599 ZNF793 ZNF383 ZNF671 ZNF676 ZNF211 ZNF146 ZNF585A ZNF670 ZNF559 ZNF674 ZNF846 ZNF329 ZNF506 ZNF480 ZNF208 ZNF214 ZNF215 ZNF615 ZNF227 ZNF112 ZNF91 ZNF850 ZNF416 ZNF879 ZBTB14 ZNF260 ZNF345 ZNF71 ZNF585B ZNF445 ZNF707 | 4.19e-26 | 679 | 77 | 32 | 3.30.160.60 |
| Domain | Znf_C2H2/integrase_DNA-bd | ZNF599 ZNF793 ZNF383 ZNF671 ZNF676 ZNF211 ZNF146 ZNF585A ZNF670 ZNF559 ZNF674 ZNF846 ZNF329 ZNF506 ZNF480 ZNF208 ZNF214 ZNF215 ZNF615 ZNF227 ZNF112 ZNF91 ZNF850 ZNF416 ZNF879 ZBTB14 ZNF260 ZNF345 ZNF71 ZNF585B ZNF445 ZNF707 | 8.26e-26 | 694 | 77 | 32 | IPR013087 |
| Domain | KRAB | ZNF599 ZNF793 ZNF383 ZNF671 ZNF676 ZNF211 ZNF585A ZNF670 ZNF559 ZNF674 ZNF846 ZNF506 ZNF480 ZNF208 ZNF214 ZNF215 ZNF615 ZNF227 ZNF112 ZNF91 ZNF850 ZNF416 ZNF879 ZNF585B ZNF445 ZNF707 | 8.57e-26 | 358 | 77 | 26 | PS50805 |
| Domain | ZINC_FINGER_C2H2_2 | ZNF599 ZNF793 ZNF383 TSHZ3 ZNF671 ZNF676 ZNF211 ZNF146 ZNF585A ZNF670 ZNF559 ZNF674 ZNF846 ZNF329 ZNF506 ZNF480 ZNF208 ZNF214 ZNF215 ZNF615 ZNF227 ZNF112 ZNF91 ZNF850 ZNF416 ZNF879 ZBTB14 ZNF260 ZNF345 ZNF71 ZNF585B ZNF445 ZNF707 | 1.42e-25 | 775 | 77 | 33 | PS50157 |
| Domain | ZINC_FINGER_C2H2_1 | ZNF599 ZNF793 ZNF383 TSHZ3 ZNF671 ZNF676 ZNF211 ZNF146 ZNF585A ZNF670 ZNF559 ZNF674 ZNF846 ZNF329 ZNF506 ZNF480 ZNF208 ZNF214 ZNF215 ZNF615 ZNF227 ZNF112 ZNF91 ZNF850 ZNF416 ZNF879 ZBTB14 ZNF260 ZNF345 ZNF71 ZNF585B ZNF445 ZNF707 | 1.54e-25 | 777 | 77 | 33 | PS00028 |
| Domain | KRAB | ZNF599 ZNF793 ZNF383 ZNF671 ZNF676 ZNF211 ZNF585A ZNF670 ZNF559 ZNF674 ZNF846 ZNF506 ZNF480 ZNF208 ZNF214 ZNF215 ZNF615 ZNF227 ZNF112 ZNF91 ZNF850 ZNF416 ZNF879 ZNF585B ZNF445 ZNF707 | 1.88e-25 | 369 | 77 | 26 | SM00349 |
| Domain | KRAB | ZNF599 ZNF793 ZNF383 ZNF671 ZNF676 ZNF211 ZNF585A ZNF670 ZNF559 ZNF674 ZNF846 ZNF506 ZNF480 ZNF208 ZNF214 ZNF215 ZNF615 ZNF227 ZNF112 ZNF91 ZNF850 ZNF416 ZNF879 ZNF585B ZNF445 ZNF707 | 2.02e-25 | 370 | 77 | 26 | IPR001909 |
| Domain | Znf_C2H2-like | ZNF599 ZNF793 ZNF383 TSHZ3 ZNF671 ZNF676 ZNF211 ZNF146 ZNF585A ZNF670 ZNF559 ZNF674 ZNF846 ZNF329 ZNF506 ZNF480 ZNF208 ZNF214 ZNF215 ZNF615 ZNF227 ZNF112 ZNF91 ZNF850 ZNF416 ZNF879 ZBTB14 ZNF260 ZNF345 ZNF71 ZNF585B ZNF445 ZNF707 | 3.32e-25 | 796 | 77 | 33 | IPR015880 |
| Domain | Znf_C2H2 | ZNF599 ZNF793 ZNF383 TSHZ3 ZNF671 ZNF676 ZNF211 ZNF146 ZNF585A ZNF670 ZNF559 ZNF674 ZNF846 ZNF329 ZNF506 ZNF480 ZNF208 ZNF214 ZNF215 ZNF615 ZNF227 ZNF112 ZNF91 ZNF850 ZNF416 ZNF879 ZBTB14 ZNF260 ZNF345 ZNF71 ZNF585B ZNF445 ZNF707 | 4.74e-25 | 805 | 77 | 33 | IPR007087 |
| Domain | ZnF_C2H2 | ZNF599 ZNF793 ZNF383 TSHZ3 ZNF671 ZNF676 ZNF211 ZNF146 ZNF585A ZNF670 ZNF559 ZNF674 ZNF846 ZNF329 ZNF506 ZNF480 ZNF208 ZNF214 ZNF215 ZNF615 ZNF227 ZNF112 ZNF91 ZNF850 ZNF416 ZNF879 ZBTB14 ZNF260 ZNF345 ZNF71 ZNF585B ZNF445 ZNF707 | 5.34e-25 | 808 | 77 | 33 | SM00355 |
| Domain | KRAB | ZNF599 ZNF793 ZNF383 ZNF671 ZNF211 ZNF585A ZNF670 ZNF559 ZNF674 ZNF846 ZNF506 ZNF480 ZNF208 ZNF214 ZNF215 ZNF615 ZNF227 ZNF112 ZNF91 ZNF850 ZNF416 ZNF879 ZNF585B ZNF445 ZNF707 | 2.36e-24 | 358 | 77 | 25 | PF01352 |
| Domain | zf-C2H2_6 | ZNF671 ZNF676 ZNF211 ZNF670 ZNF846 ZNF329 ZNF506 ZNF480 ZNF208 ZNF615 ZNF227 ZNF91 ZNF850 ZNF416 ZNF879 ZNF260 ZNF345 ZNF71 ZNF445 | 2.36e-17 | 314 | 77 | 19 | PF13912 |
| Domain | zf-H2C2_2 | ZNF599 ZNF383 ZNF846 ZNF345 | 2.59e-07 | 14 | 77 | 4 | PF13465 |
| Domain | ABC_A | ABCA10 ABCA9 | 1.08e-03 | 12 | 77 | 2 | IPR026082 |
| Domain | EGF_extracell | ATRN DNER NOTCH1 | 1.95e-03 | 60 | 77 | 3 | IPR013111 |
| Domain | EGF_2 | ATRN DNER NOTCH1 | 1.95e-03 | 60 | 77 | 3 | PF07974 |
| Domain | DEAD/DEAH_box_helicase_dom | BLM DDX49 DDX27 | 3.41e-03 | 73 | 77 | 3 | IPR011545 |
| Domain | DEAD | BLM DDX49 DDX27 | 3.41e-03 | 73 | 77 | 3 | PF00270 |
| Domain | hEGF | DNER NOTCH1 | 5.92e-03 | 28 | 77 | 2 | PF12661 |
| Domain | DEAD_ATP_HELICASE | DDX49 DDX27 | 7.22e-03 | 31 | 77 | 2 | PS00039 |
| Domain | RNA-helicase_DEAD-box_CS | DDX49 DDX27 | 8.15e-03 | 33 | 77 | 2 | IPR000629 |
| Domain | Helicase_C | BLM DDX49 DDX27 | 9.84e-03 | 107 | 77 | 3 | PF00271 |
| Domain | HELICc | BLM DDX49 DDX27 | 9.84e-03 | 107 | 77 | 3 | SM00490 |
| Domain | Helicase_C | BLM DDX49 DDX27 | 1.01e-02 | 108 | 77 | 3 | IPR001650 |
| Domain | Q_MOTIF | DDX49 DDX27 | 1.02e-02 | 37 | 77 | 2 | PS51195 |
| Domain | RNA_helicase_DEAD_Q_motif | DDX49 DDX27 | 1.02e-02 | 37 | 77 | 2 | IPR014014 |
| Domain | HELICASE_CTER | BLM DDX49 DDX27 | 1.03e-02 | 109 | 77 | 3 | PS51194 |
| Domain | HELICASE_ATP_BIND_1 | BLM DDX49 DDX27 | 1.03e-02 | 109 | 77 | 3 | PS51192 |
| Domain | DEXDc | BLM DDX49 DDX27 | 1.03e-02 | 109 | 77 | 3 | SM00487 |
| Domain | Helicase_ATP-bd | BLM DDX49 DDX27 | 1.06e-02 | 110 | 77 | 3 | IPR014001 |
| Pathway | REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION | BLM ZNF599 ZNF793 ZNF383 ZNF671 ZNF676 ZNF211 ZNF585A ZNF670 ZNF559 ZNF506 ZNF480 ZNF208 ZNF214 ZNF215 ZNF615 ZNF227 ZNF112 ZNF416 NOTCH1 ZNF71 ZNF585B ZNF445 ZNF707 | 1.71e-10 | 1387 | 57 | 24 | M734 |
| Pathway | REACTOME_GENERIC_TRANSCRIPTION_PATHWAY | BLM ZNF383 ZNF585A ZNF670 ZNF208 ZNF112 ZNF91 ZNF850 ZNF416 NOTCH1 ZNF585B ZNF445 | 4.59e-05 | 768 | 57 | 12 | MM14851 |
| Pathway | REACTOME_GENE_EXPRESSION_TRANSCRIPTION | BLM ZNF383 ZNF585A ZNF670 ZNF208 POLR1B ZNF112 ZNF91 ZNF850 ZNF416 NOTCH1 ZNF585B ZNF445 | 1.73e-04 | 1022 | 57 | 13 | MM15436 |
| Pubmed | Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. | ZNF383 ZNF211 ZNF670 ZNF480 ZNF208 ZNF615 ZNF227 ZNF91 ZNF445 ZNF707 | 1.36e-11 | 181 | 80 | 10 | 37372979 |
| Pubmed | Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. | ZNF585A ZNF670 ZNF208 ZNF91 ZNF850 ZNF585B ZNF445 | 2.07e-11 | 49 | 80 | 7 | 9630514 |
| Pubmed | Specific and ubiquitous expression of different Zn finger protein genes in the mouse. | ZNF585A ZNF850 ZNF585B | 4.07e-07 | 7 | 80 | 3 | 3143103 |
| Pubmed | Expression patterns of the three Teashirt-related genes define specific boundaries in the developing and postnatal mouse forebrain. | TSHZ3 ISL2 ISL1 | 6.51e-07 | 8 | 80 | 3 | 15834955 |
| Pubmed | SoxC Transcription Factors Promote Contralateral Retinal Ganglion Cell Differentiation and Axon Guidance in the Mouse Visual System. | ISL2 ISL1 NOTCH1 | 1.39e-06 | 10 | 80 | 3 | 28215559 |
| Pubmed | Notch1 control of oligodendrocyte differentiation in the spinal cord. | ISL2 ISL1 NOTCH1 | 1.91e-06 | 11 | 80 | 3 | 12186854 |
| Pubmed | A Disintegrin and Metalloproteinase10 (ADAM10) Regulates NOTCH Signaling during Early Retinal Development. | ISL2 ISL1 NOTCH1 | 1.91e-06 | 11 | 80 | 3 | 27224017 |
| Pubmed | Teashirt 3 regulates development of neurons involved in both respiratory rhythm and airflow control. | TSHZ3 ISL2 ISL1 | 1.91e-06 | 11 | 80 | 3 | 20631175 |
| Pubmed | Altered neuronal lineages in the facial ganglia of Hoxa2 mutant mice. | ISL2 ISL1 NOTCH1 | 4.19e-06 | 14 | 80 | 3 | 18164701 |
| Pubmed | A novel familial 11p15.4 microduplication associated with intellectual disability, dysmorphic features, and obesity with involvement of the ZNF214 gene. | ZNF214 ZNF215 | 5.23e-06 | 2 | 80 | 2 | 22052655 |
| Pubmed | Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease. | ZNF585A ZNF585B | 5.23e-06 | 2 | 80 | 2 | 37668106 |
| Pubmed | The zinc finger-only protein Zfp260 is a novel cardiac regulator and a nuclear effector of alpha1-adrenergic signaling. | ZNF146 ZNF260 | 5.23e-06 | 2 | 80 | 2 | 16166646 |
| Pubmed | Morphogenetic targets and genetics of undescended testis. | ZNF214 ZNF215 | 5.23e-06 | 2 | 80 | 2 | 20980787 |
| Pubmed | Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas. | FOXN1 NSD1 | 5.23e-06 | 2 | 80 | 2 | 36206767 |
| Pubmed | Cloning, characterization, and chromosome assignment of Zfp146 the mouse ortholog of human ZNF146, a gene amplified and overexpressed in pancreatic cancer, and Zfp260 a closely related gene. | ZNF146 ZNF260 | 5.23e-06 | 2 | 80 | 2 | 10449921 |
| Pubmed | Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome. | ZNF214 ZNF215 | 5.23e-06 | 2 | 80 | 2 | 10762538 |
| Pubmed | Chromosomal region 11p15 is associated with male factor subfertility. | ZNF214 ZNF215 | 5.23e-06 | 2 | 80 | 2 | 12970396 |
| Pubmed | Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. | ZNF208 ZNF112 ZNF91 | 6.42e-06 | 16 | 80 | 3 | 8467795 |
| Pubmed | Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease. | ATRN ZNF793 SYNJ1 ZNF329 DNER ZNF214 ZNF227 MBD4 TRIP12 WDR26 TF DDX27 ZNF879 | 7.11e-06 | 1285 | 80 | 13 | 35914814 |
| Pubmed | Asymmetric activation of Dll4-Notch signaling by Foxn4 and proneural factors activates BMP/TGFβ signaling to specify V2b interneurons in the spinal cord. | ISL2 ISL1 NOTCH1 | 7.79e-06 | 17 | 80 | 3 | 24257627 |
| Pubmed | SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis. | ISL2 ISL1 NOTCH1 | 7.79e-06 | 17 | 80 | 3 | 21478884 |
| Pubmed | Wilms Tumor Predisposition | BLM BRCA2 NSD1 | 9.33e-06 | 18 | 80 | 3 | 20301471 |
| Pubmed | Teashirt 1 (Tshz1) is essential for the development, survival and function of hypoglossal and phrenic motor neurons in mouse. | TSHZ3 ISL2 ISL1 | 1.11e-05 | 19 | 80 | 3 | 31427287 |
| Pubmed | Glycine release from radial cells modulates the spontaneous activity and its propagation during early spinal cord development. | ISL2 ISL1 | 1.57e-05 | 3 | 80 | 2 | 20053920 |
| Pubmed | Differential Islet-1 expression among lumbosacral spinal motor neurons in prenatal mouse. | ISL2 ISL1 | 1.57e-05 | 3 | 80 | 2 | 19236857 |
| Pubmed | Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation. | FOXN1 NOTCH1 | 1.57e-05 | 3 | 80 | 2 | 19103190 |
| Pubmed | Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity. | FOXN1 NOTCH1 | 1.57e-05 | 3 | 80 | 2 | 31562298 |
| Pubmed | Initial trajectories of sensory axons toward laminar targets in the developing mouse spinal cord. | ISL2 ISL1 | 1.57e-05 | 3 | 80 | 2 | 9100133 |
| Pubmed | ECEL1 mutation implicates impaired axonal arborization of motor nerves in the pathogenesis of distal arthrogryposis. | ISL2 ISL1 | 1.57e-05 | 3 | 80 | 2 | 26951213 |
| Pubmed | Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition. | FOXN1 BRCA2 | 1.57e-05 | 3 | 80 | 2 | 21555554 |
| Pubmed | Interaction with BRCA2 suggests a role for filamin-1 (hsFLNa) in DNA damage response. | FLNA BRCA2 | 1.57e-05 | 3 | 80 | 2 | 11602572 |
| Pubmed | Sex steroid blockade enhances thymopoiesis by modulating Notch signaling. | FOXN1 NOTCH1 | 1.57e-05 | 3 | 80 | 2 | 25332287 |
| Pubmed | Islet-1 expression in thoracic spinal motor neurons in prenatal mouse. | ISL2 ISL1 | 1.57e-05 | 3 | 80 | 2 | 21651972 |
| Pubmed | Expression of sorting nexin 18 (SNX18) is dynamically regulated in developing spinal motor neurons. | ISL2 ISL1 | 1.57e-05 | 3 | 80 | 2 | 21339182 |
| Pubmed | An integrated physical map of 210 markers assigned to the short arm of human chromosome 11. | ZNF214 ZNF215 | 1.57e-05 | 3 | 80 | 2 | 7959730 |
| Pubmed | Emergence of sigh rhythmogenesis in the embryonic mouse. | ISL2 ISL1 | 1.57e-05 | 3 | 80 | 2 | 24591570 |
| Pubmed | The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing. | BLM FLNA DDX49 RRP1B RBM19 POLR1B TF DDX27 | 1.58e-05 | 483 | 80 | 8 | 36912080 |
| Pubmed | The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. | BLM ATRN FLNA ZNF146 IGF2R RRP1B ZNF329 ZNF227 ZNF850 HSDL1 ZNF260 ZNF707 | 1.91e-05 | 1203 | 80 | 12 | 29180619 |
| Pubmed | Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation. | ISL2 FGF13 ISL1 | 2.29e-05 | 24 | 80 | 3 | 21734270 |
| Pubmed | The Krüppel-like zinc finger protein GLIS3 transactivates neurogenin 3 for proper fetal pancreatic islet differentiation in mice. | ISL2 ISL1 NOTCH1 | 2.60e-05 | 25 | 80 | 3 | 21786021 |
| Pubmed | The structural role of radial glial endfeet in confining spinal motor neuron somata is controlled by the Reelin and Notch pathways. | ISL2 ISL1 NOTCH1 | 2.93e-05 | 26 | 80 | 3 | 23988635 |
| Pubmed | Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. | FOXN1 NOTCH1 | 3.13e-05 | 4 | 80 | 2 | 18824585 |
| Pubmed | Coinheritance of BRCA1 and BRCA2 mutations with Fanconi anemia and Bloom syndrome mutations in Ashkenazi Jewish population: possible role in risk modification for cancer development. | BLM BRCA2 | 3.13e-05 | 4 | 80 | 2 | 15726604 |
| Pubmed | Generation and characterization of Rgs4 mutant mice. | ISL2 ISL1 | 3.13e-05 | 4 | 80 | 2 | 15870291 |
| Pubmed | Robo1 and 2 Repellent Receptors Cooperate to Guide Facial Neuron Cell Migration and Axon Projections in the Embryonic Mouse Hindbrain. | ISL2 ISL1 | 3.13e-05 | 4 | 80 | 2 | 30685539 |
| Pubmed | Necdin plays a role in the serotonergic modulation of the mouse respiratory network: implication for Prader-Willi syndrome. | ISL2 ISL1 | 3.13e-05 | 4 | 80 | 2 | 18272695 |
| Pubmed | KPC2 relocalizes HOXA2 to the cytoplasm and decreases its transcriptional activity. | ISL2 ISL1 | 3.13e-05 | 4 | 80 | 2 | 26303204 |
| Pubmed | Timeless Maintains Genomic Stability and Suppresses Sister Chromatid Exchange during Unperturbed DNA Replication. | BLM BRCA2 | 3.13e-05 | 4 | 80 | 2 | 19112184 |
| Pubmed | A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. | BLM BRCA2 | 3.13e-05 | 4 | 80 | 2 | 22789542 |
| Pubmed | Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification. | ISL2 ISL1 | 3.13e-05 | 4 | 80 | 2 | 22025611 |
| Pubmed | A new role for angiogenin in neurite growth and pathfinding: implications for amyotrophic lateral sclerosis. | ISL2 ISL1 | 3.13e-05 | 4 | 80 | 2 | 17468498 |
| Pubmed | Increased apoptosis of motoneurons and altered somatotopic maps in the brachial spinal cord of Hoxc-8-deficient mice. | ISL2 ISL1 | 3.13e-05 | 4 | 80 | 2 | 9486801 |
| Pubmed | BRCA2 localization to the midbody by filamin A regulates cep55 signaling and completion of cytokinesis. | FLNA BRCA2 | 3.13e-05 | 4 | 80 | 2 | 22771033 |
| Pubmed | Prenatal methamphetamine exposure causes dysfunction in glucose metabolism and low birthweight. | ISL2 ISL1 | 3.13e-05 | 4 | 80 | 2 | 36353228 |
| Pubmed | Identification of STAM1 as a novel effector of ventral projection of spinal motor neurons. | ISL2 ISL1 | 3.13e-05 | 4 | 80 | 2 | 27161150 |
| Pubmed | Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons. | ISL2 ISL1 NOTCH1 | 3.29e-05 | 27 | 80 | 3 | 24496616 |
| Pubmed | Multimodal Hox5 activity generates motor neuron diversity. | TSHZ3 ISL2 ISL1 | 4.10e-05 | 29 | 80 | 3 | 39289460 |
| Pubmed | Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression. | ZNF506 ZNF208 ZNF91 | 4.10e-05 | 29 | 80 | 3 | 14563677 |
| Pubmed | GDE2 regulates subtype-specific motor neuron generation through inhibition of Notch signaling. | ISL2 ISL1 NOTCH1 | 4.55e-05 | 30 | 80 | 3 | 21943603 |
| Pubmed | The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling. | ISL2 ISL1 NOTCH1 | 5.03e-05 | 31 | 80 | 3 | 22508726 |
| Pubmed | The DNA sequence and biology of human chromosome 19. | ZNF146 DDX49 ZNF208 ZNF112 USF2 ZNF71 | 5.09e-05 | 284 | 80 | 6 | 15057824 |
| Pubmed | Retinal axon misrouting at the optic chiasm in mice with neural tube closure defects. | ISL2 ISL1 | 5.20e-05 | 5 | 80 | 2 | 10862153 |
| Pubmed | Sonic hedgehog regulates the position of the trigeminal ganglia. | ISL2 ISL1 | 5.20e-05 | 5 | 80 | 2 | 14499653 |
| Pubmed | Forced expression of Phox2 homeodomain transcription factors induces a branchio-visceromotor axonal phenotype. | ISL2 ISL1 | 5.20e-05 | 5 | 80 | 2 | 17208219 |
| Pubmed | The IGF2 receptor is a USF2-specific target in nontumorigenic mammary epithelial cells but not in breast cancer cells. | IGF2R USF2 | 5.20e-05 | 5 | 80 | 2 | 12857727 |
| Pubmed | Distinct timing of neurogenesis of ipsilateral and contralateral retinal ganglion cells. | ISL2 ISL1 | 5.20e-05 | 5 | 80 | 2 | 29761490 |
| Pubmed | Expression patterns of Hox10 paralogous genes during lumbar spinal cord development. | ISL2 ISL1 | 5.20e-05 | 5 | 80 | 2 | 16495162 |
| Pubmed | Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene. | ISL2 ISL1 | 5.20e-05 | 5 | 80 | 2 | 9806916 |
| Pubmed | Targeting of the EphA4 tyrosine kinase receptor affects dorsal/ventral pathfinding of limb motor axons. | ISL2 ISL1 | 5.20e-05 | 5 | 80 | 2 | 10887087 |
| Pubmed | Genetics of mirror movements identifies a multifunctional complex required for Netrin-1 guidance and lateralization of motor control. | ISL2 ISL1 | 5.20e-05 | 5 | 80 | 2 | 37172092 |
| Pubmed | Delayed neurogenesis leads to altered specification of ventrotemporal retinal ganglion cells in albino mice. | ISL2 ISL1 | 5.20e-05 | 5 | 80 | 2 | 24885435 |
| Pubmed | Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells. | ISL2 ISL1 | 5.20e-05 | 5 | 80 | 2 | 9000074 |
| Pubmed | Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development. | FOXN1 NOTCH1 | 5.20e-05 | 5 | 80 | 2 | 32255245 |
| Pubmed | The embryonic development of hindbrain respiratory networks is unaffected by mutation of the planar polarity protein Scribble. | ISL2 ISL1 | 5.20e-05 | 5 | 80 | 2 | 28583412 |
| Pubmed | Notch post-translationally regulates β-catenin protein in stem and progenitor cells. | ISL1 NOTCH1 | 5.20e-05 | 5 | 80 | 2 | 21841793 |
| Pubmed | The transcriptional control of trunk neural crest induction, survival, and delamination. | ISL2 ISL1 NOTCH1 | 6.66e-05 | 34 | 80 | 3 | 15691760 |
| Pubmed | Genetic identification of an embryonic parafacial oscillator coupling to the preBötzinger complex. | ISL2 ISL1 | 7.79e-05 | 6 | 80 | 2 | 19578380 |
| Pubmed | Necdin protects embryonic motoneurons from programmed cell death. | ISL2 ISL1 | 7.79e-05 | 6 | 80 | 2 | 21912643 |
| Pubmed | Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases sigma and delta. | ISL2 ISL1 | 7.79e-05 | 6 | 80 | 2 | 16738228 |
| Pubmed | Generation of a novel functional neuronal circuit in Hoxa1 mutant mice. | ISL2 ISL1 | 7.79e-05 | 6 | 80 | 2 | 11466434 |
| Pubmed | Glial cell line-derived neurotrophic factor and developing mammalian motoneurons: regulation of programmed cell death among motoneuron subtypes. | ISL2 ISL1 | 7.79e-05 | 6 | 80 | 2 | 10864958 |
| Pubmed | The relative efficiency of homology-directed repair has distinct effects on proper anaphase chromosome separation. | BLM BRCA2 | 7.79e-05 | 6 | 80 | 2 | 21459848 |
| Pubmed | LncRNA Litchi is a regulator for harmonizing maturity and resilient functionality in spinal motor neurons. | ISL2 ISL1 | 7.79e-05 | 6 | 80 | 2 | 38433925 |
| Pubmed | Regulation of continuous but complex expression pattern of Six1 during early sensory development. | ISL2 ISL1 | 7.79e-05 | 6 | 80 | 2 | 29106072 |
| Pubmed | Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo. | ISL2 ISL1 | 7.79e-05 | 6 | 80 | 2 | 9272948 |
| Pubmed | Heterogeneous Origin of Gonadotropin Releasing Hormone-1 Neurons in Mouse Embryos Detected by Islet-1/2 Expression. | ISL2 ISL1 | 7.79e-05 | 6 | 80 | 2 | 32083082 |
| Pubmed | Pax6 influences the time and site of origin of glial precursors in the ventral neural tube. | ISL2 ISL1 | 7.79e-05 | 6 | 80 | 2 | 9828088 |
| Pubmed | Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis. | ISL2 ISL1 | 7.79e-05 | 6 | 80 | 2 | 28892058 |
| Pubmed | Semaphorin 3A-Neuropilin-1 signaling regulates peripheral axon fasciculation and pathfinding but not developmental cell death patterns. | ISL2 ISL1 | 7.79e-05 | 6 | 80 | 2 | 20345923 |
| Pubmed | Expression of Deltex1 during mouse embryogenesis: comparison with Notch1, 2 and 3 expression. | ISL1 NOTCH1 | 7.79e-05 | 6 | 80 | 2 | 11731257 |
| Pubmed | Juxtaposition of CNR protocadherins and reelin expression in the developing spinal cord. | ISL2 ISL1 | 7.79e-05 | 6 | 80 | 2 | 11312598 |
| Pubmed | The HMG box transcription factor gene Sox14 marks a novel subset of ventral interneurons and is regulated by sonic hedgehog. | ISL2 ISL1 | 7.79e-05 | 6 | 80 | 2 | 10677261 |
| Pubmed | Netrin-1 acts as a repulsive guidance cue for sensory axonal projections toward the spinal cord. | ISL2 ISL1 | 7.79e-05 | 6 | 80 | 2 | 18842897 |
| Pubmed | Short-term lineage analysis of dorsally derived Olig3 cells in the developing spinal cord. | ISL2 ISL1 | 7.79e-05 | 6 | 80 | 2 | 16145668 |
| Pubmed | RAG-2 deficiency results in fewer phosphorylated histone H2AX foci, but increased retinal ganglion cell death and altered axonal growth. | ISL2 ISL1 | 7.79e-05 | 6 | 80 | 2 | 31811168 |
| Pubmed | Integrity of developing spinal motor columns is regulated by neural crest derivatives at motor exit points. | ISL2 ISL1 | 7.79e-05 | 6 | 80 | 2 | 12575949 |
| Pubmed | Spatiotemporal features of early neuronogenesis differ in wild-type and albino mouse retina. | ISL2 ISL1 | 7.79e-05 | 6 | 80 | 2 | 12040030 |
| Pubmed | Activation of Six1 Expression in Vertebrate Sensory Neurons. | ISL2 ISL1 | 7.79e-05 | 6 | 80 | 2 | 26313368 |
| Pubmed | Breathing without CO(2) chemosensitivity in conditional Phox2b mutants. | ISL2 ISL1 | 7.79e-05 | 6 | 80 | 2 | 21900566 |
| Pubmed | Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. | TCEA3 ZNF670 ZNF506 ISL2 ZNF208 ZNF91 USF2 ZNF260 ZNF445 | 1.00e-04 | 808 | 80 | 9 | 20412781 |
| Interaction | TRIM28 interactions | ZNF383 ZNF211 ZNF670 BRCA2 RRP1B ZNF674 DZIP3 ZNF480 ZNF208 POLR1B ZNF615 ZNF227 ZNF112 ZNF91 TRIP12 WDR26 ZNF416 HSDL1 NOTCH1 ZNF585B ZNF445 ZNF707 | 1.79e-08 | 1474 | 77 | 22 | int:TRIM28 |
| Interaction | ANOS1 interactions | BLM TSHZ3 RRP1B NSD1 TRIP12 DDX27 | 1.80e-05 | 143 | 77 | 6 | int:ANOS1 |
| Interaction | NDEL1 interactions | ZNF599 ZNF211 ZNF91 ZNF260 ZNF445 ZNF707 | 3.90e-05 | 164 | 77 | 6 | int:NDEL1 |
| Interaction | LHX1 interactions | BLM ZNF146 ISL2 ISL1 DDX27 | 4.67e-05 | 103 | 77 | 5 | int:LHX1 |
| Interaction | TRIM39 interactions | ZNF383 ZNF214 ZNF112 ZNF416 ZNF707 | 5.85e-05 | 108 | 77 | 5 | int:TRIM39 |
| Interaction | ZNF467 interactions | BLM ZNF211 NSD1 ZNF480 DDX27 ZNF445 | 6.35e-05 | 179 | 77 | 6 | int:ZNF467 |
| Cytoband | Ensembl 112 genes in cytogenetic band chr19q13 | ZNF599 ZNF793 ZNF383 ZNF671 ZNF211 ZNF146 ZNF585A ZNF329 ZNF480 ZNF615 ZNF227 ZNF112 USF2 ZNF850 ZNF416 ZNF260 ZNF345 ZNF71 ZNF585B | 1.68e-13 | 1192 | 80 | 19 | chr19q13 |
| Cytoband | 19q13.12 | ZNF793 ZNF383 ZNF585A ZNF850 ZNF260 ZNF345 ZNF585B | 5.01e-11 | 72 | 80 | 7 | 19q13.12 |
| Cytoband | 19p12 | ZNF676 DDX49 ZNF208 ZNF723 ZNF91 | 5.54e-07 | 90 | 80 | 5 | 19p12 |
| Cytoband | Ensembl 112 genes in cytogenetic band chr19p12 | ZNF676 ZNF208 ZNF723 ZNF91 | 6.42e-05 | 122 | 80 | 4 | chr19p12 |
| Cytoband | 19q13.4 | ZNF211 ZNF416 ZNF71 | 3.66e-04 | 79 | 80 | 3 | 19q13.4 |
| Cytoband | 2q36.3 | DNER TRIP12 | 6.77e-04 | 22 | 80 | 2 | 2q36.3 |
| GeneFamily | Zinc fingers C2H2-type|ZF class homeoboxes and pseudogenes | ZNF599 ZNF793 ZNF383 TSHZ3 ZNF671 ZNF676 ZNF211 ZNF146 ZNF585A ZNF670 ZNF559 ZNF674 ZNF846 ZNF329 ZNF506 ZNF480 ZNF208 ZNF214 ZNF215 ZNF615 ZNF227 ZNF112 ZNF91 ZNF850 ZNF416 ZNF879 ZBTB14 ZNF260 ZNF345 ZNF71 ZNF585B ZNF445 ZNF707 | 1.13e-28 | 718 | 67 | 33 | 28 |
| GeneFamily | LIM class homeoboxes | ISL2 ISL1 | 8.72e-04 | 12 | 67 | 2 | 522 |
| GeneFamily | ATP binding cassette subfamily A | ABCA10 ABCA9 | 1.20e-03 | 14 | 67 | 2 | 805 |
| Coexpression | NIKOLSKY_BREAST_CANCER_19Q13.1_AMPLICON | ZNF793 ZNF383 ZNF585A ZNF260 ZNF345 ZNF585B | 4.43e-11 | 22 | 79 | 6 | M8692 |
| Coexpression | MIKKELSEN_NPC_ICP_WITH_H3K4ME3 | ZNF585A ZNF670 ZNF208 ZNF112 ZNF91 ZNF416 ABCA9 ZNF260 ZNF585B | 1.87e-05 | 497 | 79 | 9 | MM863 |
| Coexpression | GSE22601_DOUBLE_POSITIVE_VS_CD4_SINGLE_POSITIVE_THYMOCYTE_UP | RRP1B STK17B ZNF329 ZNF112 ZNF91 ZNF879 | 2.86e-05 | 196 | 79 | 6 | M6227 |
| Coexpression | GSE24142_ADULT_VS_FETAL_EARLY_THYMIC_PROGENITOR_UP | CPQ STK17B ZNF329 DNER FGF13 ZNF260 | 3.20e-05 | 200 | 79 | 6 | M4576 |
| ToppCell | Fetal_brain-organoid_Tanaka_cellReport-GW13-Mesenchymal-Mesoderm|GW13 / Sample Type, Dataset, Time_group, and Cell type. | ZNF383 TSHZ3 ZNF211 ZNF846 ZNF214 ZNF71 | 1.64e-06 | 200 | 80 | 6 | 0f4b8b0868bda406fe6bf01d1b722510fdfd0168 |
| Drug | prantal | IGF2R NSD1 ZNF214 ZNF215 | 2.13e-07 | 16 | 77 | 4 | CID000006126 |
| Drug | Urosiol [128-13-2]; Down 200; 10.2uM; MCF7; HT_HG-U133A | ATRN RRP1B RBM19 DZIP3 PLCH1 USF2 ZBTB14 | 5.19e-06 | 200 | 77 | 7 | 6484_DN |
| Disease | delta/notch like EGF Repeat Containing protein measurement | DNER TRIP12 | 6.55e-06 | 2 | 76 | 2 | EFO_0010781 |
| Disease | delta and Notch-like epidermal growth factor-related receptor measurement | DNER TRIP12 | 1.96e-05 | 3 | 76 | 2 | EFO_0802458 |
| Disease | uveal melanoma (is_implicated_in) | BRCA2 MBD4 | 3.92e-05 | 4 | 76 | 2 | DOID:6039 (is_implicated_in) |
| Disease | Acute lymphocytic leukemia | BLM NOTCH1 | 1.36e-04 | 7 | 76 | 2 | C0023449 |
| Disease | triacylglycerol 58:12 measurement | DNER TRIP12 | 4.25e-04 | 12 | 76 | 2 | EFO_0010439 |
| Disease | nephroblastoma (is_implicated_in) | IGF2R BRCA2 | 5.84e-04 | 14 | 76 | 2 | DOID:2154 (is_implicated_in) |
| Disease | type 1 diabetes mellitus (is_implicated_in) | IGF2R ISL1 TF | 1.39e-03 | 85 | 76 | 3 | DOID:9744 (is_implicated_in) |
| Disease | apolipoprotein B measurement | IGF2R BRCA2 ZNF329 MACROD1 ZNF112 ABCA10 ABCA9 | 1.60e-03 | 663 | 76 | 7 | EFO_0004615 |
| Disease | congenital heart disease (is_implicated_in) | ISL1 NOTCH1 | 1.74e-03 | 24 | 76 | 2 | DOID:1682 (is_implicated_in) |
| Disease | cerebral amyloid deposition measurement | ZNF850 ZBTB14 ZNF260 | 1.92e-03 | 95 | 76 | 3 | EFO_0007707 |
| Disease | Miller Dieker syndrome | BLM BRCA2 | 2.54e-03 | 29 | 76 | 2 | C0265219 |
