Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmicrotubule binding

MACF1 WASL SPAG5 GAS2

3.90e-04308234GO:0008017
GeneOntologyMolecularFunctiontubulin binding

MACF1 WASL SPAG5 GAS2

1.33e-03428234GO:0015631
GeneOntologyMolecularFunctionactin binding

MACF1 WASL PLEC GAS2

2.02e-03479234GO:0003779
GeneOntologyMolecularFunctionactin filament binding

MACF1 PLEC GAS2

2.17e-03227233GO:0051015
DomainPlectin_repeat

MACF1 PPL PLEC

6.50e-087243IPR001101
DomainPlectin

MACF1 PPL PLEC

6.50e-087243PF00681
DomainPLEC

MACF1 PPL PLEC

6.50e-087243SM00250
DomainSpectrin_repeat

MACF1 PPL PLEC

6.66e-0629243IPR002017
DomainSpectrin/alpha-actinin

MACF1 PPL PLEC

9.02e-0632243IPR018159
DomainSPEC

MACF1 PPL PLEC

9.02e-0632243SM00150
DomainGAR

MACF1 GAS2

2.37e-056242PS51460
Domain-

MACF1 GAS2

2.37e-0562423.30.920.20
Domain-

MACF1 PLEC

2.37e-0562423.90.1290.10
DomainGAS_dom

MACF1 GAS2

2.37e-056242IPR003108
DomainGAS2

MACF1 GAS2

2.37e-056242PF02187
DomainGAS2

MACF1 GAS2

2.37e-056242SM00243
DomainCH

MACF1 PLEC GAS2

7.73e-0565243SM00033
DomainCH

MACF1 PLEC GAS2

9.64e-0570243PF00307
Domain-

MACF1 PLEC GAS2

1.01e-04712431.10.418.10
DomainCH

MACF1 PLEC GAS2

1.09e-0473243PS50021
DomainCH-domain

MACF1 PLEC GAS2

1.18e-0475243IPR001715
DomainActinin_actin-bd_CS

MACF1 PLEC

3.94e-0423242IPR001589
DomainACTININ_2

MACF1 PLEC

3.94e-0423242PS00020
DomainACTININ_1

MACF1 PLEC

3.94e-0423242PS00019
DomainBTB

BACH2 KLHL31

1.22e-02131242PF00651
DomainBTB

BACH2 KLHL31

1.78e-02160242PS50097
PathwayREACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS

PLEC GAS2

1.38e-0412212MM14908
PathwayREACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS

PLEC GAS2

1.38e-0412212M3634
PathwayREACTOME_INTERLEUKIN_7_SIGNALING

SMARCA4 IL7

2.19e-0415212MM14536
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

DCAF17 INTS2 MACF1 GLG1 USP45 SPAG5 CNTRL PLEC

4.09e-07108424811544199
Pubmed

Cytolinker cross-talk: periplakin N-terminus interacts with plectin to regulate keratin organisation and epithelial migration.

PPL PLEC

4.56e-07224217662978
Pubmed

Plakins: a family of versatile cytolinker proteins.

PPL PLEC

1.37e-06324211854008
Pubmed

EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions.

GPC6 SPAG5 PLEC

1.12e-056324329162697
Pubmed

Differential regulation and impact of fucosyltransferase VII and core 2 β1,6-N-acetyl-glycosaminyltransferase for generation of E-selectin and P-selectin ligands in murine CD4+ T cells.

GLG1 IL7

1.27e-05824223039181
Pubmed

A conserved acetylation switch enables pharmacological control of tubby-like protein stability.

GPC6 IFT140 GLG1 BACH2

1.58e-0522324433187986
Pubmed

Plakin proteins are coordinately cleaved during apoptosis but preferentially through the action of different caspases.

PPL PLEC

1.64e-05924215500642
Pubmed

A human MAP kinase interactome.

MACF1 IFT140 WASL CNTRL PLEC

1.78e-0548624520936779
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

WASL BACH2 SPAG5 CNTRL PLEC VCPIP1

1.97e-0585324628718761
Pubmed

POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.

DENND5B GLG1 SPAG5 PLEC

3.69e-0527724430745168
Pubmed

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.

SMARCA4 IFT140 CNTRL

4.47e-0510024325807483
Pubmed

ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1.

BACH2 CNTRL PLEC

6.43e-0511324334474245
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

DCAF17 DENND5B GLG1 CNTRL GAS2

9.16e-0568624529987050
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

GPC6 INTS2 IFT140 GLG1 BACH2 CCDC160

1.59e-04124224630973865
Pubmed

Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation.

SMARCA4 IKBKE

1.71e-042824230037996
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

SPAG5 PLEC ZKSCAN4 VCPIP1

1.81e-0441824434709266
Pubmed

RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.

SMARCA4 PLEC

1.83e-042924236800290
Pubmed

A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.

SMARCA4 IKBKE GLG1

1.87e-0416224314743216
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

MACF1 GLG1 SPAG5 CNTRL PLEC

1.96e-0480724530575818
Pubmed

Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC.

MACF1 PLEC

2.83e-043624216097034
Pubmed

An Interaction Landscape of Ubiquitin Signaling.

MACF1 GLG1 PLEC VCPIP1

3.08e-0448124428190767
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

SMARCA4 MACF1 GLG1 SPAG5 PLEC VCPIP1

3.21e-04141524628515276
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

SMARCA4 PPL VCPIP1

3.89e-0420824333230847
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

MACF1 SPAG5 VCPIP1

3.94e-0420924336779422
Pubmed

Phosphoproteome analysis of the human mitotic spindle.

PPL SPAG5 PLEC

4.00e-0421024316565220
Pubmed

FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.

SMARCA4 GLG1 PLEC

4.11e-0421224333462405
Pubmed

Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice.

GPC6 GAS2

4.84e-044724215172686
Pubmed

PIP30/FAM192A is a novel regulator of the nuclear proteasome activator PA28γ.

SMARCA4 PLEC

4.84e-044724229934401
Pubmed

The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.

GLG1 WASL GAS2

5.21e-0423024335449600
Pubmed

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

GPC6 MACF1 VCPIP1

5.28e-0423124316452087
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

SMARCA4 MACF1 PLEC

5.48e-0423424336243803
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

MACF1 PPL PLEC VCPIP1

5.66e-0456524425468996
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

INTS2 SPAG5 VCPIP1

6.04e-0424224334011540
Pubmed

Functional proteomics mapping of a human signaling pathway.

MACF1 PPL PLEC VCPIP1

6.69e-0459124415231748
Pubmed

Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.

GPC6 SMARCA4 GLG1

6.72e-0425124328077445
InteractionPSMD14 interactions

DENND5B IKBKE GLG1 SPAG5 CNTRL PLEC

2.15e-05527236int:PSMD14
Cytoband16p13.3

IFT140 PPL

7.19e-0324424216p13.3
CytobandEnsembl 112 genes in cytogenetic band chr16p13

IFT140 PPL

2.07e-02426242chr16p13
GeneFamilyEF-hand domain containing|Plakins

MACF1 PPL PLEC

3.18e-088163939
GeneFamilyBasic leucine zipper proteins|BTB domain containing

BACH2 KLHL31

6.11e-03134162861
CoexpressionBILANGES_SERUM_SENSITIVE_VIA_TSC2

SMARCA4 GLG1 SPAG5

3.29e-0632243MM1307
CoexpressionBILANGES_SERUM_SENSITIVE_VIA_TSC2

SMARCA4 GLG1 SPAG5

3.29e-0632243M2334
CoexpressionGSE2706_UNSTIM_VS_2H_R848_DC_UP

GLG1 SPAG5 CNTRL VCPIP1

2.81e-05195244M4691
CoexpressionAtlasDevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_k-means-cluster#5_top-relative-expression-ranked_500

GPC6 DCAF17 WASL CNTRL

2.66e-05156244gudmap_developingKidney_e15.5_ureter tip_flank cortic collct_500_k5
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-B_cells-Cycling_plasma_cell|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SMARCA4 BACH2 SPAG5 CNTRL

3.68e-06199244c9d15c84b9f8c87b4ea0008be7d5efc5f45efd1a
ToppCelldroplet-Heart-nan-24m-Mesenchymal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPC6 CCDC160 USP45

8.30e-051592437ad3a91d29639b32f6264c91f401c14a35469ac0
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_2|356C / Donor, Lineage, Cell class and subclass (all cells)

INTS2 IL7 VCPIP1

1.16e-041782438b939659f713eea50a1a6e28b571f680ca0b4c12
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DENND5B BACH2 IL7

1.22e-041812430c52dd82e6b3dce3d6bb5c13501bf8383f7121e4
ToppCelldroplet-Marrow-nan-3m-Myeloid-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MACF1 BACH2 CNTRL

1.24e-04182243f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

GPC6 MACF1 BACH2

1.28e-04184243d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_2|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

INTS2 IL7 VCPIP1

1.30e-04185243e06a784a297f357f3f8e761c24fa70722048ab42
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MACF1 BACH2 CNTRL

1.30e-041852437adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCellCOVID-19-lung-B_cells|COVID-19 / Disease (COVID-19 only), tissue and cell type

DENND5B BACH2 CNTRL

1.30e-04185243e8f1ad580f19705b5ca1d7d8867b2125f4891684
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMARCA4 BACH2 SPAG5

1.32e-041862433993f1ef8a33b8a75dfd3db8d4845b5afbb0bb3d
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMARCA4 BACH2 SPAG5

1.32e-04186243ec6d0c29e196e374baa96dd3d506f489c959e77e
ToppCellPND10|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SMARCA4 MACF1 GLG1

1.41e-04190243d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

GPC6 DENND5B MACF1

1.45e-04192243e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellhuman_hepatoblastoma-Tumor_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

GPC6 DENND5B GAS2

1.47e-04193243503a979328c68b096680b71359a26f02fafdff35
ToppCellfacs-Marrow-B-cells-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND5B SMARCA4 BACH2

1.47e-0419324324c34c6635eb7fc2878282803c421b64320e77d8
ToppCelldroplet-Marrow-nan-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMARCA4 BACH2 CNTRL

1.49e-041942438ef0b71fef5b84cfd04973f891215333e7035d1d
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND5B SMARCA4 BACH2

1.49e-041942437ee8ac172c2dee7df7dc4eb222e0985a0089bda8
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMARCA4 BACH2 SPAG5

1.52e-041952435749ea833be84e262e3d0a4fe1a9a373f0ef545f
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMARCA4 BACH2 SPAG5

1.52e-04195243294c74336fafc1bad237d851efb4a487475078eb
ToppCellSepsis-ICU-NoSEP-Lymphocyte-B-B_intermediate|ICU-NoSEP / Disease, condition lineage and cell class

DENND5B BACH2 IL7

1.61e-0419924397a32b664c89e865cf29f83add794d277fa020cd
Drugplakin

MACF1 PPL PLEC GAS2

1.57e-0682244CID000018752
DrugCilligen

PPL PLEC

1.59e-056242CID003085040
DrugAC1L1X4J

PPL PLEC

2.97e-058242CID000011330
DrugCephalosporanic acid, 7-amino [957-68-6]; Down 200; 14.6uM; MCF7; HT_HG-U133A

SMARCA4 IFT140 GLG1 PLEC

4.95e-051962444826_DN
DrugUngerine nitrate; Up 200; 10.2uM; PC3; HT_HG-U133A

SMARCA4 IKBKE IFT140 GLG1

5.04e-051972445816_UP
DrugEthamsylate [2624-44-4]; Down 200; 15.2uM; PC3; HT_HG-U133A

DCAF17 IKBKE GLG1 IL7

5.14e-051982444576_DN
Drug1-methylphenanthrene

SPAG5 PLEC

5.82e-0511242CID000013257
Diseaseresponse to methotrexate, neurotoxicity

GPC6 MACF1

1.08e-0419242EFO_0011057, GO_0031427
DiseaseLeber Congenital Amaurosis

IFT140 USP45

1.45e-0422242C0339527
Diseasecancer (implicated_via_orthology)

SMARCA4 MACF1 ACAP3

1.30e-03268243DOID:162 (implicated_via_orthology)
Diseasemetabolite measurement, diet measurement

SMARCA4 ZKSCAN4

1.52e-0371242EFO_0004725, EFO_0008111
Diseasethyroid peroxidase antibody measurement

GLG1 BACH2

1.57e-0372242EFO_0005666
DiseaseDisproportionate short stature

GPC6 IFT140

1.79e-0377242C0878659
Diseasemigraine disorder

MACF1 WASL C3orf38

2.94e-03357243MONDO_0005277
Diseasecholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement

SMARCA4 MACF1

3.17e-03103242EFO_0008595, EFO_0020944
Diseaseeosinophil measurement

SMARCA4 BACH2

3.48e-03108242EFO_0803540
Diseaseinterleukin-6 measurement

GPC6 BACH2

3.73e-03112242EFO_0004810
Diseasecholesterol:total lipids ratio, intermediate density lipoprotein measurement

SMARCA4 MACF1

4.34e-03121242EFO_0008595, EFO_0020943
Diseaseloneliness measurement

MACF1 C3orf38

4.55e-03124242EFO_0007865
Diseasetriglycerides:total lipids ratio, intermediate density lipoprotein measurement

SMARCA4 MACF1

4.77e-03127242EFO_0008595, EFO_0020947
Diseasetotal blood protein measurement

IKBKE MACF1 BACH2

5.59e-03449243EFO_0004536

Protein segments in the cluster

PeptideGeneStartEntry
IAEQFMQQKLDLGCA

DCAF17

241

Q5H9S7
ERNQLKACMGELLDN

BACH2

691

Q9BYV9
ENMCNLQKLNLAGNE

CNTRL

166

Q7Z7A1
ELLKLMCELGNSAVN

ACAP3

466

Q96P50
EGLSKMRQENFLCDL

KLHL31

61

Q9H511
LCEGMKLLASDLLDN

IKBKE

686

Q14164
KGQELAAMACELQAQ

PPL

651

O60437
NKGMEEGEDNLLCNL

INTS2

976

Q9H0H0
VCALQNEFLGKDMLI

MACF1

2786

Q9UPN3
QIDSGDLMECLIQNK

GLG1

711

Q92896
LNVMKGCLANQADLD

GPC6

271

Q9Y625
NLLGLLDNDEIMALC

C3orf38

16

Q5JPI3
CLNLLNEELEELNMK

CCDC160

146

A6NGH7
NLLEMTFECQNLGKL

DENND5B

976

Q6ZUT9
DQLLDSMKEIGSNCL

IL7

46

P13232
CKENGLDDQLMNLAL

IFT140

1046

Q96RY7
TFMEKLDNGALLCQL

GAS2

56

O43903
CAQDLAMKDELLCQL

SPAG5

746

Q96R06
SLNDLEKDVMLLCQN

SMARCA4

1521

P51532
ELLMGNNKLLCENCT

USP45

631

Q70EL2
TKLQMEAGLCEEQLN

PLEC

536

Q15149
AKLLRDMNQGELFDC

VCPIP1

146

Q96JH7
DQGQELLCCKMALLT

ZKSCAN4

146

Q969J2
NNLDPELKNLFDMCG

WASL

226

O00401