Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

MYCN NCOA3 REL PITX1 ARNT2

1.43e-04560195GO:0001228
GeneOntologyMolecularFunctiontranscription coregulator activity

CARM1 BCL9L NCOA3 NRG1 MRTFB

1.45e-04562195GO:0003712
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

MYCN NCOA3 REL PITX1 ARNT2

1.50e-04566195GO:0001216
GeneOntologyMolecularFunctiontranscription coactivator activity

CARM1 BCL9L NCOA3 MRTFB

1.68e-04303194GO:0003713
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

MYCN NCOA3 REL KLF18 DLX1 PITX1 ARNT2

2.06e-041412197GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

MYCN NCOA3 REL KLF18 DLX1 PITX1 ARNT2

2.52e-041459197GO:0000977
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

MYCN REL KLF18 DLX1 PITX1 ARNT2

7.75e-041244196GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

MYCN REL KLF18 DLX1 PITX1 ARNT2

8.68e-041271196GO:0000987
GeneOntologyMolecularFunctionnuclear receptor coactivator activity

CARM1 NCOA3

1.52e-0361192GO:0030374
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

CARM1 NCOA3 PITX1 ARNT2

1.95e-03582194GO:0140297
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

CARM1 BCL9L NCOA3 NRG1 MRTFB

3.85e-031160195GO:0030674
GeneOntologyMolecularFunctiontranscription factor binding

CARM1 NCOA3 PITX1 ARNT2

4.95e-03753194GO:0008134
GeneOntologyMolecularFunctionbeta-catenin binding

CARM1 BCL9L

5.73e-03120192GO:0008013
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

NCOA3 PITX1 ARNT2

6.83e-03417193GO:0061629
GeneOntologyMolecularFunctionmolecular adaptor activity

CARM1 BCL9L NCOA3 NRG1 MRTFB

7.47e-031356195GO:0060090
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

CARM1 MYCN BCL9L NCOA3 REL DLX1 MRTFB PITX1 ARNT2

1.39e-061390199GO:0045944
GeneOntologyBiologicalProcesscentral nervous system development

MYCN GRIA1 NRG1 DLX1 MRTFB PITX1 ARNT2

5.92e-051197197GO:0007417
GeneOntologyBiologicalProcessforebrain development

GRIA1 NRG1 DLX1 MRTFB PITX1

6.48e-05489195GO:0030900
GeneOntologyBiologicalProcessbrain development

GRIA1 NRG1 DLX1 MRTFB PITX1 ARNT2

8.73e-05859196GO:0007420
GeneOntologyBiologicalProcesshead development

GRIA1 NRG1 DLX1 MRTFB PITX1 ARNT2

1.27e-04919196GO:0060322
GeneOntologyBiologicalProcessmyoblast differentiation

BCL9L NRG1 PITX1

2.51e-04136193GO:0045445
GeneOntologyBiologicalProcessregulation of gliogenesis

MYCN NRG1 DLX1

3.42e-04151193GO:0014013
GeneOntologyBiologicalProcessregulation of intracellular estrogen receptor signaling pathway

CARM1 NCOA3

4.97e-0436192GO:0033146
GeneOntologyBiologicalProcessnegative regulation of glial cell differentiation

MYCN DLX1

5.84e-0439192GO:0045686
GeneOntologyBiologicalProcessmuscle organ development

BCL9L NRG1 MRTFB PITX1

5.93e-04436194GO:0007517
GeneOntologyCellularComponenttranscription regulator complex

CARM1 BCL9L NCOA3 PITX1 ARNT2

1.55e-04596195GO:0005667
GeneOntologyCellularComponentchromatin

MYCN NCOA3 REL DLX1 PITX1 ARNT2

1.52e-031480196GO:0000785
GeneOntologyCellularComponentRNA polymerase II transcription regulator complex

CARM1 BCL9L NCOA3

1.81e-03272193GO:0090575
GeneOntologyCellularComponentpresynaptic active zone membrane

GRIA1 NRG1

2.26e-0378192GO:0048787
GeneOntologyCellularComponentneuromuscular junction

GRIA1 NRG1

4.58e-03112192GO:0031594
Domain-

MYCN NCOA3 ARNT2

1.02e-041091634.10.280.10
DomainHLH

MYCN NCOA3 ARNT2

1.08e-04111163PF00010
DomainHLH

MYCN NCOA3 ARNT2

1.23e-04116163SM00353
DomainBHLH

MYCN NCOA3 ARNT2

1.26e-04117163PS50888
DomainbHLH_dom

MYCN NCOA3 ARNT2

1.30e-04118163IPR011598
DomainPAS

NCOA3 ARNT2

2.04e-0425162PF00989
DomainPAS_fold

NCOA3 ARNT2

2.04e-0425162IPR013767
DomainPAS

NCOA3 ARNT2

3.36e-0432162SM00091
DomainPAS

NCOA3 ARNT2

3.80e-0434162IPR000014
DomainPAS

NCOA3 ARNT2

3.80e-0434162PS50112
DomainHomeobox_CS

DLX1 PITX1

1.08e-02186162IPR017970
DomainHomeobox

DLX1 PITX1

1.67e-02234162PF00046
DomainHOMEOBOX_1

DLX1 PITX1

1.70e-02236162PS00027
DomainHOX

DLX1 PITX1

1.71e-02237162SM00389
DomainHomeobox_dom

DLX1 PITX1

1.74e-02239162IPR001356
DomainHOMEOBOX_2

DLX1 PITX1

1.74e-02239162PS50071
PathwayREACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA

CARM1 NCOA3 ARNT2

1.19e-04118123M27316
PathwayBIOCARTA_VDR_PATHWAY

CARM1 NCOA3

1.52e-0422122MM1370
PathwayREACTOME_LONG_TERM_POTENTIATION

GRIA1 NRG1

1.66e-0423122M27949
Pubmed

Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene.

CARM1 NCOA3

2.83e-07219216938873
Pubmed

Analysis of the REL, BCL11A, and MYCN proto-oncogenes belonging to the 2p amplicon in chronic lymphocytic leukemia.

MYCN REL

8.48e-07319220575024
Pubmed

Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death.

CARM1 NCOA3

1.70e-06419226267537
Pubmed

A transcriptional switch mediated by cofactor methylation.

CARM1 NCOA3

1.70e-06419211701890
Pubmed

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

NCOA3 REL DLX1 PITX1 ARNT2

2.05e-0640219524722188
Pubmed

Dual role of the arginine methyltransferase CARM1 in the regulation of c-Fos target genes.

CARM1 NCOA3

2.82e-06519218511550
Pubmed

Fertility comparison between wild type and transgenic mice by in vitro fertilization.

NRG1 RBP3

2.82e-06519219844803
Pubmed

Role of nuclear receptor coactivator 3 (Ncoa3) in pluripotency maintenance.

CARM1 NCOA3

2.82e-06519222977234
Pubmed

Regulation of transcription by a protein methyltransferase.

CARM1 NCOA3

2.82e-06519210381882
Pubmed

Steroid receptor coactivator 3 is a coactivator for myocardin, the regulator of smooth muscle transcription and differentiation.

NCOA3 MRTFB

2.82e-06519217360478
Pubmed

Structural and Functional Impacts of ER Coactivator Sequential Recruitment.

CARM1 NCOA3

4.24e-06619228844863
Pubmed

Expression patterns of Brx1 (Rieg gene), Sonic hedgehog, Nkx2.2, Dlx1 and Arx during zona limitans intrathalamica and embryonic ventral lateral geniculate nuclear formation.

DLX1 PITX1

4.24e-0661929347917
Pubmed

Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly.

CARM1 NCOA3

4.24e-06619216923966
Pubmed

Jaw transformation with gain of symmetry after Dlx5/Dlx6 inactivation: mirror of the past?

DLX1 PITX1

4.24e-06619212434331
Pubmed

The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation.

CARM1 NCOA3

5.93e-06719217043108
Pubmed

A census of human transcription factors: function, expression and evolution.

MYCN NCOA3 REL DLX1 PITX1 ARNT2

6.32e-0690819619274049
Pubmed

Neuregulin repellent signaling via ErbB4 restricts GABAergic interneurons to migratory paths from ganglionic eminence to cortical destinations.

NRG1 DLX1

7.90e-06819222376909
Pubmed

Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activities.

CARM1 NCOA3

7.90e-06819211050077
Pubmed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.

MYCN NRG1 DLX1 ARNT2

9.43e-0625119429031500
Pubmed

Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity.

CARM1 NCOA3

1.02e-05919214966289
Pubmed

Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways.

CARM1 NCOA3

1.86e-051219215383283
Pubmed

Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation.

MYCN NCOA3 ARNT2

2.03e-059819318557763
Pubmed

Allocation of paraventricular and supraoptic neurons requires Sim1 function: a role for a Sim1 downstream gene PlexinC1.

DLX1 ARNT2

3.38e-051619217356169
Pubmed

Slit2 activity in the migration of guidepost neurons shapes thalamic projections during development and evolution.

NRG1 DLX1

3.83e-051719221435555
Pubmed

Directed Bmp4 expression in neural crest cells generates a genetic model for the rare human bony syngnathia birth defect.

DLX1 PITX1

3.83e-051719224785830
Pubmed

Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort.

CARM1 NCOA3

3.83e-051719219183483
Pubmed

Threshold-specific requirements for Bmp4 in mandibular development.

DLX1 PITX1

4.30e-051819215936012
Pubmed

Atypical Protein Kinase C-Dependent Polarized Cell Division Is Required for Myocardial Trabeculation.

MYCN NRG1

5.34e-052019226876178
Pubmed

Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy.

MYCN NRG1

5.34e-052019223314057
Pubmed

Mesodermal Tbx1 is required for patterning the proximal mandible in mice.

DLX1 PITX1

6.49e-052219220501333
Pubmed

Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs.

DLX1 PITX1

7.75e-052419218697905
Pubmed

Islet1 regulates establishment of the posterior hindlimb field upstream of the Hand2-Shh morphoregulatory gene network in mouse embryos.

MYCN PITX1

8.42e-052519222438573
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

MYCN NCOA3 REL DLX1 ARNT2

8.73e-0587719520211142
Pubmed

The Vertebrate Genome Annotation browser 10 years on.

CFAP47 SRRM2 PITX1

9.27e-0516319324316575
Pubmed

Full function of exon junction complex factor, Rbm8a, is critical for interneuron development.

GRIA1 DLX1

1.06e-042819233154347
Pubmed

Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action.

CARM1 NCOA3

1.06e-042819224880616
Pubmed

Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons.

NRG1 DLX1

1.06e-042819220392955
Pubmed

Murine chromosomal location of eight members of the hepatocyte nuclear factor 3/fork head winged helix family of transcription factors.

MYCN REL

1.14e-04291927789972
Pubmed

The CARM1-p300-c-Myc-Max (CPCM) transcriptional complex regulates the expression of CUL4A/4B and affects the stability of CRL4 E3 ligases in colorectal cancer.

CARM1 NCOA3

1.48e-043319232140074
Pubmed

The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.

CARM1 MYCN PITX1

1.48e-0419119324146773
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

MYCN DLX1 PITX1 ARNT2

1.90e-0454419428473536
Pubmed

Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.

MYCN NRG1

1.96e-043819229743679
Pubmed

Olig3 regulates early cerebellar development.

MYCN ARNT2

2.18e-044019233591268
Pubmed

Heterozygous variants in SIX3 and POU1F1 cause pituitary hormone deficiency in mouse and man.

MYCN PITX1

2.76e-044519235951005
Pubmed

Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.

CARM1 NCOA3 REL

3.27e-0425019318660489
Pubmed

Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis.

MYCN BCL9L

3.83e-045319224982181
InteractionSP7 interactions

MYCN BCL9L NCOA3 DLX1 PITX1

4.03e-06304175int:SP7
InteractionNCOA3 interactions

CARM1 NCOA3 MRTFB ARNT2

3.16e-05224174int:NCOA3
InteractionTFAP2D interactions

MYCN PITX1 ARNT2

5.41e-0589173int:TFAP2D
InteractionSPAG8 interactions

CARM1 PITX1 RBP3

5.79e-0591173int:SPAG8
InteractionCDX4 interactions

DLX1 PITX1

6.99e-0515172int:CDX4
InteractionDHPS interactions

SRRM2 REL DLX1

7.89e-05101173int:DHPS
InteractionARNT2 interactions

NCOA3 REL ARNT2

8.13e-05102173int:ARNT2
InteractionSMARCE1 interactions

CARM1 MYCN NCOA3 NRG1

8.28e-05287174int:SMARCE1
InteractionTLX3 interactions

BCL9L NCOA3 REL PITX1

8.74e-05291174int:TLX3
InteractionTBR1 interactions

BCL9L NCOA3 PITX1

1.10e-04113173int:TBR1
InteractionCIMIP4 interactions

CARM1 RTL9

1.14e-0419172int:CIMIP4
InteractionTSPOAP1 interactions

REL ARNT2

1.99e-0425172int:TSPOAP1
InteractionPYGO1 interactions

CARM1 BCL9L

2.50e-0428172int:PYGO1
InteractionSMARCC1 interactions

CARM1 SRRM2 MYCN NCOA3

2.54e-04384174int:SMARCC1
Cytoband5q31.1

GRIA1 PITX1

3.12e-04631925q31.1
CytobandEnsembl 112 genes in cytogenetic band chr16p13

SRRM2 MRTFB

1.32e-02426192chr16p13
GeneFamilyBasic helix-loop-helix proteins

MYCN NCOA3 ARNT2

3.49e-05110113420
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFAP47 MYCN DLX1

5.54e-051771936f3b254e56e722cc23495b49e99a4abce0243cb3
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRIA1 DLX1 PITX1

6.02e-051821935d8b7fe18286e27f0f50c5d2d9be56850e2cb8f4
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRIA1 DLX1 PITX1

6.02e-05182193904804813849b7f7f716ba1554d33b07bc0a701e
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MRTFB C12orf54 PITX1

6.31e-05185193e0172e0ab0f1d7151a3c3c63bb7c84d6bda92035
ToppCell3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NRG1 RTL9 PITX1

6.42e-05186193d3509a579871ba6a8c4edd6137b28f271c9dbe70
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SRRM2 NCOA3 REL

7.27e-05194193ff661419b697aef51a53fdeac8d37d870d65f491
ToppCellNeuron-Postmitotic-Inhibitory_Neuron-MGE2|World / Primary Cells by Cluster

GRIA1 DLX1 ARNT2

7.27e-05194193b42fd64b0fb95434a9e4e6586f31d26114a4074b
ToppCellNeuron-Postmitotic-Inhibitory_Neuron-MGE2-10|World / Primary Cells by Cluster

GRIA1 DLX1 ARNT2

7.27e-0519419381e7bc6516ab8d02ccd1c76a56a3533b788c27c8
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal-GABAergic_neurons|GW23 / Sample Type, Dataset, Time_group, and Cell type.

GRIA1 DLX1 ARNT2

7.96e-05200193c6bbd33bca86ac7a76a7ba704b3e141237d04549
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Interneuron|GW23 / Sample Type, Dataset, Time_group, and Cell type.

GRIA1 DLX1

3.25e-0463192c10d344bf32a091deb79e1f128f7dd5e9f4abaa3
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Six3-Inhibitory_Neuron.Gad1Gad2.Six3-Sst_(Reticular_formation)-|Thalamus / BrainAtlas - Mouse McCarroll V32

DLX1 RBP3

5.37e-0481192e58f07266b7bad0af9a9856c678b4e0850c9f6c9
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Six3-Inhibitory_Neuron.Gad1Gad2.Six3-Sst_(Reticular_formation)|Thalamus / BrainAtlas - Mouse McCarroll V32

DLX1 RBP3

5.37e-0481192717751c7a6af08cec7d0e561869e4b292d1f83a5
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal|GW23 / Sample Type, Dataset, Time_group, and Cell type.

GRIA1 DLX1

7.52e-049619256e993d37b7958abe56682422536045550e29b41
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Papillary_Carcinoma-8|TCGA-Breast / Sample_Type by Project: Shred V9

CFAP47 DLX1

8.49e-04102192631b22bd588e5259873b4253435a6e6b3cced346
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal|GW23 / Sample Type, Dataset, Time_group, and Cell type.

GRIA1 DLX1

1.02e-031121929c3fb470708e76a8f8a3cb9aa17ab130c60fee11
ToppCellfacs-Aorta-Heart-24m-Myeloid-professional_antigen_presenting_cell|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLF18 PITX1

1.13e-03118192171afacd54b2e447f9f8c4511e93ff4504cd47cc
ToppCellBAL-Control-cDC_7|Control / Compartment, Disease Groups and Clusters

CARM1 NRG1

1.19e-03121192b49b044a687a31883dfccecf10a183b5ba567f7a
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Neuronal-Interneuron|GW10 / Sample Type, Dataset, Time_group, and Cell type.

DLX1 ARNT2

1.29e-03126192ec445ec097c9c45cd47b8cfa8c140df5b298695e
ToppCellIonocyte-iono-4|World / Class top

FAM13C REL

1.35e-0312919285ee6e16959cb58a58f5b09edf1f78d9ce6a9441
ToppCellILEUM-non-inflamed-(3)_MNP-(3)_moDC|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

NCOA3 REL

1.48e-03135192b7a792a7c0c22d8b703509f134115f0e394d7de0
ToppCellLPS-IL1RA+antiTNF-Endothelial-Epi-like|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BCL9L GRIA1

1.63e-03142192a05b320cf182b2aaf18df7c40045dc65b659bf20
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFAP47 RTL9

1.63e-0314219201c39bb90807fa3031ba4511712440380b6069af
ToppCellLPS-IL1RA+antiTNF-Endothelial-Epi-like-Gen_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BCL9L GRIA1

1.63e-03142192d52da766e031f7409eb5a7a9fa88f48e14a79d8b
ToppCellfacs-Aorta-Heart-24m-Myeloid-nan|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLF18 PITX1

1.87e-03152192525d65c5c8e5580947367afdb1f6e68b49e9e5bb
ToppCellBAL-Mild-Myeloid-MoAM-MoAM2|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

NRG1 ARNT2

1.89e-03153192decc4f3098a9374a6b65c015a9d36380986290bf
ToppCellBAL-Mild-Myeloid-MoAM-MoAM2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NRG1 ARNT2

1.89e-031531925fbb90b8477f9fdabf3be19efd3068fbf70abee6
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BCL9L GRIA1

1.89e-03153192991782d111d66e25b40319d4e6dea40f2c2c0805
ToppCellBAL-Mild-Myeloid-MoAM-MoAM2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NRG1 ARNT2

1.89e-0315319236a28805c0545c2f410c74a6ca0a70d840e75715
ToppCellBAL-Mild-Myeloid-MoAM-MoAM2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

NRG1 ARNT2

1.89e-031531922c46183481e6d5a7fa190a743062509465f88e56
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-midbrain/hindbrain_cells|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

NRG1 RTL9

1.92e-03154192df1b58a20af73fa79c6c069c0117a9ffd85b476f
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRIA1 DLX1

1.94e-0315519272a19a9ecfd13f6769c4b447d3ce01a855ec6ec7
ToppCellTCGA-Thymus-Primary_Tumor-Thymoma-Type_C-8|TCGA-Thymus / Sample_Type by Project: Shred V9

PITX1 ARNT2

1.94e-0315519200eef9f93a753a1fe1ab5fd8dae026e7be556cde
ToppCellPND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_C|PND01-03-samps / Age Group, Lineage, Cell class and subclass

FAM13C PITX1

1.97e-031561926c8f442ed94ae31e6832b68137e98ae78091ac6c
ToppCellLPS-antiTNF-Endothelial-Mes-Like|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYCN RTL9

2.01e-0315819250df52d64d07178975563abd98ce4fddb9f2f7ef
ToppCellfacs-Aorta-Heart-24m-Myeloid|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLF18 PITX1

2.04e-03159192443f6df4a88fa8755adcde4cc12575dff614ecb4
ToppCellCOPD-Epithelial-PNEC|COPD / Disease state, Lineage and Cell class

NRG1 PITX1

2.04e-031591926018124980c55190928409f3bf41d846a118954a
ToppCellIPF-Epithelial-PNEC|IPF / Disease state, Lineage and Cell class

NRG1 PITX1

2.04e-03159192adec82df944fe8699a69ca52534353bef100f2f9
ToppCell390C-Epithelial_cells-Epithelial-H_(AT1)-|390C / Donor, Lineage, Cell class and subclass (all cells)

C12orf54 PITX1

2.07e-0316019218ae6822915d16699beb9047baeef9b006901a35
ToppCellE18.5-Immune-Immune_Myeloid-DC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFAP47 REL

2.07e-031601929f1fec2cf565193c73cc3c8a4f0476e57478e3b8
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_KLHL14|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CFAP47 DLX1

2.07e-031601921d3abf5e30318774bd1862a44a32850f47b79f4c
ToppCellmild_COVID-19_(asymptomatic)-B_intermediate|World / disease group, cell group and cell class (v2)

NCOA3 C12orf54

2.07e-031601926722934e153b72039c3c4308557d0ef879a30638
ToppCell390C-Epithelial_cells-Epithelial-H_(AT1)|390C / Donor, Lineage, Cell class and subclass (all cells)

C12orf54 PITX1

2.07e-03160192830f17bad94de05612fe6d53d39e42a4b3f3e2f3
ToppCellIPF-Epithelial-PNEC|World / Disease state, Lineage and Cell class

NRG1 PITX1

2.09e-03161192133833729ba8b6d3eef326590ca7476b17602cbb
ToppCellE18.5-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFAP47 REL

2.12e-03162192388670cf3acef17df971c0d8ae3ce14398945192
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GRIA1 DLX1

2.12e-03162192d28b2ea1d2c8f3c6a107991573471b6d0c49c4ae
ToppCellMild_COVID-19-Myeloid-MoAM2|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

NRG1 ARNT2

2.12e-03162192e5fc80ab19d513af6a7e677a5e67bfebca2e963b
ToppCellAT1_cells-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

NRG1 ARNT2

2.12e-03162192ae2ba4f21f6f6c512006fa531d670b88be7c04c9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GRIA1 DLX1

2.12e-031621925bbd7130d4dad9035e73a439dda568195c136f31
ToppCellE18.5-Immune-Immune_Myeloid-DC-cDC1|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFAP47 REL

2.12e-031621929333d923225df7bfdf6b3a4c32816751315aec50
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GRIA1 DLX1

2.12e-03162192eed223e61c8162a2fe004ab4e09de5e037be7553
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GRIA1 DLX1

2.12e-03162192e35ddce830e20ebeac1a2c405293fc4a5323dd4a
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel|Children_(3_yrs) / Lineage, Cell type, age group and donor

FAM13C MRTFB

2.14e-03163192977a970b1296234c22178420294cea73506ee02f
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

FAM13C MRTFB

2.14e-03163192ba7d02db0f0e2f9916ec8db52c067c87b6917c23
ToppCellTCGA-Thymus-Primary_Tumor-Thymoma-Type_C|TCGA-Thymus / Sample_Type by Project: Shred V9

PITX1 ARNT2

2.14e-031631922dac87d15051151ccf193760ddd8b82534c3f922
ToppCelldroplet-Liver-nan-3m-Lymphocytic|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BCL9L REL

2.17e-03164192bf0d3ad9016a0b8011a2385bb92f0a4f5edad1d6
ToppCelldroplet-Liver-nan-3m-Lymphocytic-NK/T|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BCL9L REL

2.17e-03164192c33910a6d87580902e9e7bd27afe6ea63b5eff8d
ToppCelldroplet-Liver-nan-3m-Lymphocytic-NK_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BCL9L REL

2.17e-03164192950f87d9dacee45c9004a9bf894543de38f72ee5
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FAM13C MRTFB

2.19e-031651923d14f37b8a9c0ddc1130e60a2e08556bad1fb855
ToppCellEndothelial-endothelial_cell_of_bronchial_vessel|World / Lineage, Cell type, age group and donor

FAM13C MRTFB

2.19e-0316519284e553d699ac56df89a77248f7308b9133e1b683
ToppCellLPS-antiTNF-Endothelial-Mes-Like-Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYCN RTL9

2.22e-031661923b750d4023a0a09d86113aae5a97d84391f7b482
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NRG1 C12orf54

2.22e-03166192c948df4279ff55b0d2739ad08b145c96ef2dbc97
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NRG1 PITX1

2.22e-03166192d1c61270c7b39bb365020eeafe298a8f88aa887e
ToppCellBasal_cells-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

NRG1 PITX1

2.22e-03166192aea2ae12e4746149ebc6da063ef694381c098f80
ToppCellCOVID-19-kidney-PEC|COVID-19 / Disease (COVID-19 only), tissue and cell type

NRG1 ARNT2

2.27e-03168192a086c306be430adf0632ba53e98cd8014d2de330
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP47 NRG1

2.30e-03169192fba841664939c771881ba97f14ef1df6635c04ff
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NRG1 PITX1

2.33e-03170192a7184dc41f90caa753860ed0f65a18133f84bc5f
ToppCellTCGA-Cervix|World / Sample_Type by Project: Shred V9

C12orf54 PITX1

2.33e-03170192a6cbe253bc60f5d5cb361c7e85ed9928a3155ec8
ToppCellfacs-Heart-LV-3m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRG1 REL

2.35e-0317119255b194a9bf4d3e4b5d96e0d1298424359c441cbb
ToppCellfacs|World / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCOA3 MRTFB

2.35e-031711925bcb96ed7fc15548f2dc9cf47482f890640cb39c
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-9|TCGA-Bladder / Sample_Type by Project: Shred V9

BCL9L NCOA3

2.35e-03171192adbcfa4bf6bc1c604535a24435924cdb091e2dd7
ToppCellfacs-Heart-LV-3m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRG1 REL

2.35e-03171192c6fc9ef9735dbf5314a4c7dac2b2954b0985ae4d
ToppCellnucseq-Epithelial-Epithelial_Neuro-Secretory-PNEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NRG1 PITX1

2.35e-03171192f4321133190a3df9d31f5d4021a464d3840145f1
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Activated_DCs|Myeloid_cells / Location, Cell class and cell subclass

MYCN REL

2.35e-03171192ce290930385cac35dbd21a5e91cf0f93cf3e99f8
ToppCellCOVID-19-kidney-Bcells|COVID-19 / Disease (COVID-19 only), tissue and cell type

NCOA3 REL

2.35e-031711928e8fb79968b1a5c34d1d9cad7f9155fabfdb7cc7
ToppCellfacs|World / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NCOA3 MRTFB

2.35e-03171192bb71e816dde44fda6af0ad98d979be9f8740fda6
ToppCellnucseq-Epithelial-Epithelial_Neuro-Secretory-PNEC-PNEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NRG1 PITX1

2.35e-03171192ed4fb6c84579d99df33de5f8f928c3cd2f3d3d72
ToppCellwk_20-22-Epithelial-Proximal_epithelial-Deuterosomal|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CFAP47 PITX1

2.35e-0317119252aec5f6677fe2f7a36fb5b18117a4cffaeff58f
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NRG1 ARNT2

2.38e-031721920c2d0bb767e5ce089b42ad49e8b303a103de2d5c
ToppCell390C-Epithelial_cells-Epithelial-H_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

C12orf54 PITX1

2.38e-03172192aff37b9689b0d30ee7097d997d9588efc475c8fd
ToppCell390C-Epithelial_cells-Epithelial-H_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

C12orf54 PITX1

2.38e-03172192bb542f6ca4eb8167129bc84ca1160a54fbb68731
ToppCellnucseq-Epithelial-Epithelial_Neuro-Secretory|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NRG1 PITX1

2.38e-03172192d0cdedd734406988a9a93d7300c7b1a8b4b45c38
ToppCell10x5'-Lung-Myeloid_Mac-Erythrophagocytic_macrophages|Lung / Manually curated celltypes from each tissue

NRG1 ARNT2

2.38e-03172192075b33b41c521fe2bba567878c68d86f452af680
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NRG1 ARNT2

2.38e-03172192eeed177a03c116e9815a8e086d24efc9643b16a4
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Differentiating_glia|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYCN DLX1

2.38e-03172192bc3ed05fdd94d5e1f19285aea867b1453292baec
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

FAM13C RTL9

2.41e-031731921f16d47f5548e257e4b17f8070c5619780a9c5fd
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCN DLX1

2.41e-03173192f38bf7584e08d15a6e2c116b7c3551ba475a5e14
ToppCellCOVID-19-Heart-Neuronal|Heart / Disease (COVID-19 only), tissue and cell type

GRIA1 DLX1

2.41e-031731926fb5f9e6536a5d57fd8e6657b494047a2d0bc9c7
ToppCellwk_20-22-Epithelial-Proximal_epithelial-Squamous|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

C12orf54 PITX1

2.44e-031741920a4721248ec89bc98ebe119de6e19fbfca8b5098
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Lymphoid_DC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYCN REL

2.44e-0317419216204ff504b7b382b4d90ca35003ad5336020e07
ToppCellwk_15-18-Epithelial-Proximal_epithelial-SMG_basal_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

C12orf54 PITX1

2.44e-03174192aceca0a22bb1e380835e792681cfc9b752fb5496
ToppCellAdult-Epithelial-lung_neuroendocrine_cell_(PNEC)|Adult / Lineage, Cell type, age group and donor

GRIA1 NRG1

2.46e-031751924db1a3c284488b3f6de7568363f176d74e2a4587
ToppCellAdult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231|Adult / Lineage, Cell type, age group and donor

GRIA1 NRG1

2.46e-031751928d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neuron_precursor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYCN DLX1

2.46e-031751922ce8bcf9926862e723219b4246388428d0c3fdee
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma-3|TCGA-Cervix / Sample_Type by Project: Shred V9

REL C12orf54

2.46e-031751920cc215109d9915af47e4d0a120ce2e46910715fa
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW10-Neuronal-GABAergic_neurons|GW10 / Sample Type, Dataset, Time_group, and Cell type.

DLX1 ARNT2

2.46e-03175192d4ff1f197ad4086286e86817cbff24fa718293fc
ToppCellCOVID-19-kidney-CD-IC-A|COVID-19 / Disease (COVID-19 only), tissue and cell type

FAM13C ARNT2

2.49e-0317619245028197364c64e93e3ffe86aff773d47a477d49
ToppCellNasal_Brush-Epithelial-Basal_2|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

MYCN NRG1

2.49e-03176192fc5787946f5a10056d326d070620575ae4081836
ToppCellNasal_Brush-Epithelial-Basal_2|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

MYCN NRG1

2.49e-031761925daaba0853afe7d20d4635169ccd4f96e735b938
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NCOA3 REL

2.49e-03176192d0a3e176df1270968efa79c00dc941c5e1c4f7aa
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NCOA3 REL

2.49e-03176192274458d80f9f3f080248cbf64e4784ef351e7254
Diseaseautosomal dominant intellectual developmental disorder (is_implicated_in)

SRRM2 GRIA1

5.31e-0517192DOID:0060307 (is_implicated_in)
DiseaseAutistic Disorder

GRIA1 DLX1 PITX1

5.97e-04261193C0004352
DiseasePsoriasis

CARM1 REL

6.14e-0457192C0033860
DiseasePustulosis of Palms and Soles

CARM1 REL

6.14e-0457192C0030246
Diseasevisual epilepsy (biomarker_via_orthology)

GRIA1 NRG1

1.52e-0390192DOID:11832 (biomarker_via_orthology)
DiseaseBipolar Disorder

GRIA1 NRG1 DLX1

3.35e-03477193C0005586
DiseaseNeoplastic Cell Transformation

MYCN NRG1

3.57e-03139192C0007621

Protein segments in the cluster

PeptideGeneStartEntry
MTMTTMPESLNSPVS

DLX1

1

P56177
SSPVCMDMNGMSVPT

ARNT2

321

Q9HBZ2
VSSMTVSMPSMAVSP

NRG1

456

Q02297
ISMASPMSIPTNTMH

CARM1

591

Q86X55
MMSPSQFLSSSPLRM

MRTFB

521

Q9ULH7
TQDMFSPDQSSMPMS

BCL9L

866

Q86UU0
KTMPPLGSTMMTSAC

KLF18

56

A0A0U1RQI7
TLMMTTASMSSMAPT

DEFB126

91

Q9BYW3
SMQSIPCMSHSSGMP

GRIA1

886

P42261
MSSTNTMPVSSCTPK

CFAP47

1666

Q6ZTR5
PQMTATASGMMSSMP

RTL9

821

Q8NET4
TSTSQMMPTASGDMC

RTL9

871

Q8NET4
APSSISSMTMPSSMG

PITX1

216

P78337
SSRMSCFSRPSMSPT

SRRM2

2111

Q9UQ35
GRVSSPPNAMMSSRM

NCOA3

1326

Q9Y6Q9
PSTQQFMMPRSSSRC

FAM13C

261

Q8NE31
MSNCSMTPMTSAPRT

C12orf54

66

Q6X4T0
SSPLYASMPTQMAMS

RBP3

886

P10745
MPSCSTSTMPGMICK

MYCN

1

P04198
SDPNMLSNCSVNMMT

REL

486

Q04864