| Category | Name | IntersectionWithQuery | PValue | GenesInTerm | GenesInQuery | GenesInTermInQuery | ID |
|---|---|---|---|---|---|---|---|
| GeneOntologyMolecularFunction | bitter taste receptor activity | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 TAS2R33 TAS2R36 | 9.01e-23 | 27 | 30 | 10 | GO:0033038 |
| GeneOntologyMolecularFunction | taste receptor activity | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 TAS2R33 TAS2R36 | 9.83e-22 | 33 | 30 | 10 | GO:0008527 |
| GeneOntologyMolecularFunction | G protein-coupled receptor activity | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 TAS2R33 TAS2R36 | 3.68e-07 | 884 | 30 | 10 | GO:0004930 |
| GeneOntologyMolecularFunction | transmembrane signaling receptor activity | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 TAS2R33 TAS2R36 | 1.69e-05 | 1353 | 30 | 10 | GO:0004888 |
| GeneOntologyBiologicalProcess | detection of chemical stimulus involved in sensory perception of bitter taste | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 TAS2R33 TAS2R36 | 1.89e-20 | 44 | 30 | 10 | GO:0001580 |
| GeneOntologyBiologicalProcess | sensory perception of bitter taste | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 TAS2R33 TAS2R36 | 4.96e-20 | 48 | 30 | 10 | GO:0050913 |
| GeneOntologyBiologicalProcess | detection of chemical stimulus involved in sensory perception of taste | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 TAS2R33 TAS2R36 | 7.77e-20 | 50 | 30 | 10 | GO:0050912 |
| GeneOntologyBiologicalProcess | sensory perception of taste | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 TAS2R33 TAS2R36 | 2.95e-18 | 70 | 30 | 10 | GO:0050909 |
| GeneOntologyBiologicalProcess | detection of chemical stimulus involved in sensory perception | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 TAS2R33 TAS2R36 | 9.29e-10 | 485 | 30 | 10 | GO:0050907 |
| GeneOntologyBiologicalProcess | detection of chemical stimulus | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 TAS2R33 TAS2R36 | 1.96e-09 | 524 | 30 | 10 | GO:0009593 |
| GeneOntologyBiologicalProcess | detection of stimulus | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 TAS2R33 TAS2R36 NLRC4 | 2.67e-09 | 722 | 30 | 11 | GO:0051606 |
| GeneOntologyBiologicalProcess | sensory perception of chemical stimulus | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 TAS2R33 TAS2R36 | 2.96e-09 | 547 | 30 | 10 | GO:0007606 |
| GeneOntologyBiologicalProcess | detection of stimulus involved in sensory perception | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 TAS2R33 TAS2R36 | 5.35e-09 | 582 | 30 | 10 | GO:0050906 |
| GeneOntologyBiologicalProcess | sensory perception | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 TAS2R33 TAS2R36 | 1.60e-06 | 1072 | 30 | 10 | GO:0007600 |
| GeneOntologyBiologicalProcess | G protein-coupled receptor signaling pathway | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 TAS2R33 TAS2R36 | 1.67e-05 | 1395 | 30 | 10 | GO:0007186 |
| GeneOntologyCellularComponent | motile cilium | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 MROH2B PRAMEF20 | 3.91e-11 | 355 | 30 | 10 | GO:0031514 |
| GeneOntologyCellularComponent | cilium | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 MROH2B PRAMEF20 | 2.79e-07 | 898 | 30 | 10 | GO:0005929 |
| Domain | T2R | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 | 1.30e-17 | 26 | 28 | 8 | IPR007960 |
| Domain | TAS2R | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 | 1.30e-17 | 26 | 28 | 8 | PF05296 |
| Domain | RUN | 3.27e-04 | 18 | 28 | 2 | SM00593 | |
| Domain | RUN | 3.65e-04 | 19 | 28 | 2 | PS50826 | |
| Domain | RUN | 3.65e-04 | 19 | 28 | 2 | PF02759 | |
| Domain | Run_dom | 3.65e-04 | 19 | 28 | 2 | IPR004012 | |
| Domain | - | 3.07e-03 | 679 | 28 | 5 | 3.30.160.60 | |
| Domain | Znf_C2H2/integrase_DNA-bd | 3.37e-03 | 694 | 28 | 5 | IPR013087 | |
| Domain | HEAT_REPEAT | 4.91e-03 | 70 | 28 | 2 | PS50077 | |
| Domain | ZINC_FINGER_C2H2_2 | 5.39e-03 | 775 | 28 | 5 | PS50157 | |
| Domain | ZINC_FINGER_C2H2_1 | 5.45e-03 | 777 | 28 | 5 | PS00028 | |
| Domain | Znf_C2H2-like | 6.03e-03 | 796 | 28 | 5 | IPR015880 | |
| Domain | Znf_C2H2 | 6.32e-03 | 805 | 28 | 5 | IPR007087 | |
| Domain | ZnF_C2H2 | 6.42e-03 | 808 | 28 | 5 | SM00355 | |
| Pathway | REACTOME_SENSORY_PERCEPTION_OF_TASTE | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 | 8.81e-18 | 31 | 18 | 8 | MM15691 |
| Pathway | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 | 4.30e-17 | 37 | 18 | 8 | MM15067 |
| Pathway | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | 2.18e-14 | 39 | 18 | 7 | M793 | |
| Pathway | KEGG_TASTE_TRANSDUCTION | 1.88e-13 | 52 | 18 | 7 | M5785 | |
| Pathway | WP_GPCRS_ODORANT | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 | 7.88e-12 | 157 | 18 | 8 | MM15872 |
| Pathway | REACTOME_SENSORY_PERCEPTION_OF_TASTE | 1.78e-11 | 47 | 18 | 6 | M42524 | |
| Pathway | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | TAS2R45 TAS2R31 TAS2R43 TAS2R20 CCL28 TAS2R19 TAS2R30 TAS2R46 TAS2R50 | 2.34e-11 | 289 | 18 | 9 | MM15057 |
| Pathway | REACTOME_SENSORY_PERCEPTION | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 | 3.66e-11 | 190 | 18 | 8 | MM15687 |
| Pathway | REACTOME_GPCR_LIGAND_BINDING | TAS2R45 TAS2R31 TAS2R43 TAS2R20 CCL28 TAS2R19 TAS2R30 TAS2R46 TAS2R50 | 8.02e-10 | 430 | 18 | 9 | MM15160 |
| Pathway | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | TAS2R31 TAS2R43 TAS2R20 CCL28 TAS2R19 TAS2R30 TAS2R46 TAS2R50 | 2.00e-09 | 314 | 18 | 8 | M600 |
| Pathway | REACTOME_SIGNALING_BY_GPCR | TAS2R45 TAS2R31 TAS2R43 TAS2R20 CCL28 TAS2R19 TAS2R30 TAS2R46 TAS2R50 | 2.83e-08 | 646 | 18 | 9 | MM14962 |
| Pathway | REACTOME_GPCR_LIGAND_BINDING | TAS2R31 TAS2R43 TAS2R20 CCL28 TAS2R19 TAS2R30 TAS2R46 TAS2R50 | 4.18e-08 | 463 | 18 | 8 | M507 |
| Pathway | REACTOME_SIGNALING_BY_GPCR | TAS2R31 TAS2R43 TAS2R20 CCL28 TAS2R19 TAS2R30 TAS2R46 TAS2R50 | 1.02e-06 | 702 | 18 | 8 | M746 |
| Pathway | REACTOME_SENSORY_PERCEPTION | 9.60e-05 | 636 | 18 | 6 | M41834 | |
| Pubmed | The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 | 5.45e-23 | 12 | 30 | 8 | 12379855 |
| Pubmed | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 | 1.42e-22 | 13 | 30 | 8 | 15938754 | |
| Pubmed | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 | 2.23e-20 | 21 | 30 | 8 | 10761934 | |
| Pubmed | Evolutionary relationships of the Tas2r receptor gene families in mouse and human. | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 | 3.50e-20 | 22 | 30 | 8 | 12734386 |
| Pubmed | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 | 1.18e-19 | 25 | 30 | 8 | 12139982 | |
| Pubmed | Molecular mechanisms of bitter and sweet taste transduction. | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 | 1.71e-19 | 26 | 30 | 8 | 11696554 |
| Pubmed | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 | 2.42e-19 | 27 | 30 | 8 | 12581520 | |
| Pubmed | Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains. | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 | 6.38e-19 | 30 | 30 | 8 | 17273929 |
| Pubmed | Adaptive diversification of bitter taste receptor genes in Mammalian evolution. | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 | 6.38e-19 | 30 | 30 | 8 | 12679530 |
| Pubmed | The molecular receptive ranges of human TAS2R bitter taste receptors. | 4.05e-17 | 23 | 30 | 7 | 20022913 | |
| Pubmed | Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. | 1.95e-16 | 28 | 30 | 7 | 15744053 | |
| Pubmed | 8.83e-16 | 34 | 30 | 7 | 15496549 | ||
| Pubmed | Identification and characterization of human taste receptor genes belonging to the TAS2R family. | 4.31e-13 | 13 | 30 | 5 | 12584440 | |
| Pubmed | 7.19e-07 | 2 | 30 | 2 | 15537898 | ||
| Pubmed | 7.19e-07 | 2 | 30 | 2 | 17702579 | ||
| Pubmed | 7.19e-07 | 2 | 30 | 2 | 33461297 | ||
| Pubmed | 4.31e-06 | 4 | 30 | 2 | 32227702 | ||
| Pubmed | 5.24e-06 | 529 | 30 | 6 | 14621295 | ||
| Pubmed | 2.58e-05 | 9 | 30 | 2 | 24720729 | ||
| Pubmed | 3.24e-04 | 709 | 30 | 5 | 22988430 | ||
| Cytoband | 12p13.2 | 4.66e-16 | 45 | 27 | 7 | 12p13.2 | |
| Cytoband | Ensembl 112 genes in cytogenetic band chr12p13 | 1.17e-09 | 353 | 27 | 7 | chr12p13 | |
| Cytoband | 18q23 | 1.34e-04 | 29 | 27 | 2 | 18q23 | |
| GeneFamily | Taste 2 receptors | TAS2R45 TAS2R31 TAS2R43 TAS2R20 TAS2R19 TAS2R30 TAS2R46 TAS2R50 TAS2R33 TAS2R36 | 7.92e-21 | 39 | 28 | 10 | 1162 |
| GeneFamily | Zinc fingers FYVE-type|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors | 1.05e-03 | 31 | 28 | 2 | 81 | |
| GeneFamily | Zinc fingers C2H2-type|ZF class homeoboxes and pseudogenes | 4.48e-03 | 718 | 28 | 5 | 28 | |
| GeneFamily | Basic leucine zipper proteins|BTB domain containing | 1.82e-02 | 134 | 28 | 2 | 861 | |
| Coexpression | GSE1740_MCSF_VS_MCSF_AND_IFNG_DAY2_DERIVED_MACROPHAGE_DN | 4.23e-05 | 199 | 26 | 4 | M6157 | |
| Coexpression | GSE1112_OT1_VS_HY_CD8AB_THYMOCYTE_RTOC_CULTURE_DN | 4.31e-05 | 200 | 26 | 4 | M6146 | |
| Disease | progression free survival, response to carboplatin, methylcobalamin deficiency type cblE, ovarian serous carcinoma | 4.49e-04 | 42 | 22 | 2 | EFO_0004920, EFO_1001516, GO_0097328, MONDO_0009354 | |
| Disease | vital capacity | 1.86e-03 | 1236 | 22 | 5 | EFO_0004312 | |
| Disease | monocyte percentage of leukocytes | 1.91e-03 | 731 | 22 | 4 | EFO_0007989 | |
| Disease | aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement | 2.41e-03 | 364 | 22 | 3 | EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946 | |
| Disease | myeloid white cell count | 4.68e-03 | 937 | 22 | 4 | EFO_0007988 | |
| Disease | body fat percentage | 5.48e-03 | 488 | 22 | 3 | EFO_0007800 | |
| Disease | phosphatidylethanolamine measurement | 7.31e-03 | 173 | 22 | 2 | EFO_0010228 | |
| Disease | cortical thickness | 8.56e-03 | 1113 | 22 | 4 | EFO_0004840 | |
| Disease | body weight | 1.31e-02 | 1261 | 22 | 4 | EFO_0004338 |
| Peptide | Gene | Start | Entry |
|---|---|---|---|
| KKNGKGNVCHRKKHH | 91 | Q9NRJ3 | |
| RKGHKHGKSCMNPQK | 386 | Q9UKA4 | |
| MKKKAKIGIHHKNSP | 316 | Q8N302 | |
| GEKMKILHALCGKLL | 611 | Q9NRL2 | |
| GLKNLKKMCLFHLTH | 786 | Q9NPP4 | |
| MCIKLHGVNKVGLKK | 91 | Q9P2J3 | |
| HLLCKQMSHKKVGAL | 1361 | O43432 | |
| VVMEHCLKHGLKAKK | 106 | Q7L099 | |
| SLCKHLKKMRLHSKG | 201 | P59542 | |
| SLCKHLKKMQLHGKG | 201 | P59543 | |
| SLCKHLKKMQLHGKG | 201 | P59541 | |
| SLCKHLKKMQLHGKG | 201 | P59538 | |
| SLCKHLKKMQLHSKG | 201 | P0DSN6 | |
| SLCKHLKKMQLHGKG | 201 | P0DTE0 | |
| SLCKHLKKMQLHGKG | 201 | P59537 | |
| SLCKHLKKMQLHGKG | 201 | P59539 | |
| SLCKHLKKMQLHGKG | 201 | P59540 | |
| SLCKHLKKMQLHGEG | 201 | P59544 | |
| VMEHCLKHGLKVKKS | 151 | Q96T51 | |
| GLVHLCCKKLKMLGM | 176 | Q5VT98 | |
| ASGAPHKVKKHKQLM | 1331 | Q7Z745 | |
| GCGVCGKKFKMKHHL | 401 | O43298 | |
| GKKFKMKHHLVGHMK | 406 | O43298 | |
| LKNHMKAHGPKTGSK | 291 | Q92618 | |
| KEHGKQMKKHPCRQC | 1046 | Q9HCE3 | |
| KAHILSHSGMKLHKC | 671 | Q9BYN7 | |
| AKKHGSKCLVHCKMG | 381 | Q76I76 | |
| ACKKMHILKLNRTGK | 251 | Q96DM3 | |
| GAKKMAHQLKRKCHH | 1566 | Q8IUG5 | |
| CLMKAHQGKGLKALA | 1946 | O43149 | |
| KGDMERHCATKKHKG | 891 | Q9C0G0 | |
| MKKHLNTHLLGKHGV | 1606 | Q9C0G0 |