Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein phosphatase binding

PPP2CA JUP CTNND1 PPP1R9A INSR

4.07e-05210375GO:0019903
GeneOntologyMolecularFunctionphosphatase binding

PPP2CA JUP CTNND1 PPP1R9A INSR

1.20e-04264375GO:0019902
GeneOntologyMolecularFunctiondipeptidyl-peptidase activity

DPP4 DPP9

2.18e-0412372GO:0008239
GeneOntologyMolecularFunctiontransmembrane transporter binding

PPP2CA PPP2CB FLNA PPP1R9A

2.81e-04172374GO:0044325
GeneOntologyMolecularFunctionkinase binding

PPP2CA FLNA JUP CACNB3 CTNND1 MYOM1 PPP1R9A INSR

3.28e-04969378GO:0019900
GeneOntologyMolecularFunctionprotein kinase binding

PPP2CA FLNA JUP CACNB3 CTNND1 PPP1R9A INSR

9.72e-04873377GO:0019901
GeneOntologyMolecularFunctionprotein domain specific binding

PPP2CA CTNND1 LAT2 EFS INPP5A PPP1R9A INSR

9.85e-04875377GO:0019904
GeneOntologyMolecularFunctionexopeptidase activity

DPP4 DPP9 AEBP1

1.10e-03110373GO:0008238
GeneOntologyMolecularFunctionphosphatase activity

PPP2CA PPP2CB SBF1 INPP5A

1.90e-03287374GO:0016791
GeneOntologyMolecularFunctionaminopeptidase activity

DPP4 DPP9

2.88e-0343372GO:0004177
GeneOntologyMolecularFunctiontau protein binding

PPP2CA PPP2CB

3.28e-0346372GO:0048156
GeneOntologyMolecularFunctionion channel regulator activity

FLNA CACNB3 WNK2

3.33e-03162373GO:0099106
GeneOntologyMolecularFunctioniron ion binding

JMJD6 HEPH ALOX15B

3.56e-03166373GO:0005506
GeneOntologyMolecularFunctionchannel regulator activity

FLNA CACNB3 WNK2

4.07e-03174373GO:0016247
GeneOntologyMolecularFunctiontransporter regulator activity

FLNA CACNB3 WNK2

4.26e-03177373GO:0141108
GeneOntologyMolecularFunctionpotassium channel regulator activity

FLNA WNK2

5.00e-0357372GO:0015459
GeneOntologyMolecularFunctionphosphoprotein phosphatase activity

PPP2CA PPP2CB SBF1

5.12e-03189373GO:0004721
GeneOntologyMolecularFunctionphosphoric ester hydrolase activity

PPP2CA PPP2CB SBF1 INPP5A

5.49e-03386374GO:0042578
GeneOntologyCellularComponentzonula adherens

JUP CTNND1

8.48e-058372GO:0005915
GeneOntologyCellularComponentfocal adhesion

LRP1 DPP4 FLNA JUP EFS ALOX15B

1.00e-04431376GO:0005925
GeneOntologyCellularComponentcell-substrate junction

LRP1 DPP4 FLNA JUP EFS ALOX15B

1.17e-04443376GO:0030055
GeneOntologyCellularComponentFAR/SIN/STRIPAK complex

PPP2CA PPP2CB

4.08e-0417372GO:0090443
GeneOntologyCellularComponentmembrane raft

PPP2CA DPP4 CTNND1 LAT2 INSR

4.19e-04362375GO:0045121
GeneOntologyCellularComponentmembrane microdomain

PPP2CA DPP4 CTNND1 LAT2 INSR

4.29e-04364375GO:0098857
GeneOntologyCellularComponentprotein phosphatase type 2A complex

PPP2CA PPP2CB

4.58e-0418372GO:0000159
GeneOntologyCellularComponentdendrite

LRP1 FLNA CTNND1 KIF1A INPP5A PPP1R9A INSR

6.71e-04858377GO:0030425
GeneOntologyCellularComponentdendritic tree

LRP1 FLNA CTNND1 KIF1A INPP5A PPP1R9A INSR

6.80e-04860377GO:0097447
GeneOntologyCellularComponentaxon

LRP1 PPP2CA FLNA CTNND1 KIF1A PPP1R9A INSR

8.38e-04891377GO:0030424
GeneOntologyCellularComponentgrowth cone

LRP1 FLNA CTNND1 PPP1R9A

8.97e-04245374GO:0030426
GeneOntologyCellularComponentdistal axon

LRP1 PPP2CA FLNA CTNND1 PPP1R9A

9.60e-04435375GO:0150034
GeneOntologyCellularComponentsite of polarized growth

LRP1 FLNA CTNND1 PPP1R9A

1.01e-03253374GO:0030427
GeneOntologyCellularComponentapicolateral plasma membrane

JUP CTNND1

1.12e-0328372GO:0016327
GeneOntologyCellularComponentanchoring junction

LRP1 DPP4 FLNA JUP CTNND1 EFS ALOX15B

1.43e-03976377GO:0070161
GeneOntologyCellularComponentcatenin complex

JUP CTNND1

1.46e-0332372GO:0016342
GeneOntologyCellularComponentcell leading edge

DPP4 CTNND1 DPP9 PPP1R9A INSR

1.78e-03500375GO:0031252
GeneOntologyCellularComponentplasma membrane protein complex

LRP1 FLNA JUP CACNB3 CTNND1 INSR

2.36e-03785376GO:0098797
GeneOntologyCellularComponentaxonal growth cone

LRP1 FLNA

2.88e-0345372GO:0044295
GeneOntologyCellularComponentcell-cell junction

DPP4 FLNA JUP CTNND1 ALOX15B

3.66e-03591375GO:0005911
GeneOntologyCellularComponentphosphatase complex

PPP2CA PPP2CB

4.27e-0355372GO:1903293
GeneOntologyCellularComponentprotein serine/threonine phosphatase complex

PPP2CA PPP2CB

4.27e-0355372GO:0008287
GeneOntologyCellularComponentsomatodendritic compartment

LRP1 FLNA CTNND1 KIF1A INPP5A PPP1R9A INSR

5.17e-031228377GO:0036477
GeneOntologyCellularComponentspindle pole

TUBGCP6 PPP2CA PPP2CB

5.65e-03205373GO:0000922
GeneOntologyCellularComponentadherens junction

JUP CTNND1 ALOX15B

6.20e-03212373GO:0005912
HumanPhenoOsteolysis involving bones of the lower limbs

FLNA KIF1A NOTCH2

7.14e-0613163HP:0009139
HumanPhenoOsteolytic defects of the hand bones

FLNA KIF1A NOTCH2

2.81e-0520163HP:0009699
HumanPhenoOsteolytic defects of the phalanges of the hand

FLNA KIF1A NOTCH2

2.81e-0520163HP:0009771
HumanPhenoOsteolytic defects of bones

FLNA KIF1A NOTCH2

4.33e-0523163HP:0010737
HumanPhenoOsteolysis involving bones of the upper limbs

FLNA KIF1A NOTCH2

4.33e-0523163HP:0045039
HumanPhenoNail dysplasia

FLNA JUP CTNND1 KIF1A NOTCH2 INSR

9.44e-05264166HP:0002164
HumanPhenoOsteolytic defects of the phalanges of the toes

KIF1A NOTCH2

2.56e-048162HP:0010177
HumanPhenoAbsent frontal sinuses

FLNA NOTCH2

2.56e-048162HP:0002688
HumanPhenoFoot acroosteolysis

KIF1A NOTCH2

2.56e-048162HP:0001842
HumanPhenoAbnormal sella turcica morphology

FLNA AEBP1 NOTCH2

2.71e-0442163HP:0002679
DomainArm

JUP CTNND1 ANKAR

3.36e-0531383PF00514
Domain-

DPP4 DPP9

6.02e-0563822.140.10.30
DomainDPPIV_N

DPP4 DPP9

6.02e-056382PF00930
DomainPeptidase_S9B_N

DPP4 DPP9

6.02e-056382IPR002469
DomainARM_REPEAT

JUP CTNND1 ANKAR

7.29e-0540383PS50176
DomainARM

JUP CTNND1 ANKAR

7.29e-0540383SM00185
DomainArmadillo

JUP CTNND1 ANKAR

1.18e-0447383IPR000225
DomainPeptidase_S9

DPP4 DPP9

2.19e-0411382PF00326
DomainPeptidase_S9

DPP4 DPP9

2.19e-0411382IPR001375
DomainGrowth_fac_rcpt_

LRP1 CELSR1 NOTCH2 INSR

2.77e-04156384IPR009030
DomainSer/Thr-sp_prot-phosphatase

PPP2CA PPP2CB

3.10e-0413382IPR006186
DomainSER_THR_PHOSPHATASE

PPP2CA PPP2CB

3.10e-0413382PS00125
DomainPP2Ac

PPP2CA PPP2CB

3.10e-0413382SM00156
DomainASX_HYDROXYL

LRP1 CELSR1 NOTCH2

1.10e-03100383PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

LRP1 CELSR1 NOTCH2

1.30e-03106383IPR000152
DomainCalcineurin-like_PHP_ApaH

PPP2CA PPP2CB

1.47e-0328382IPR004843
DomainMetallophos

PPP2CA PPP2CB

1.47e-0328382PF00149
DomainMetallo-depent_PP-like

PPP2CA PPP2CB

1.69e-0330382IPR029052
Domain-

PPP2CA PPP2CB

1.69e-03303823.60.21.10
DomainEGF_CA

LRP1 CELSR1 NOTCH2

1.94e-03122383SM00179
DomainEGF-like_Ca-bd_dom

LRP1 CELSR1 NOTCH2

2.03e-03124383IPR001881
DomainEGF

LRP1 CELSR1 NOTCH2

2.13e-03126383PF00008
Domain-

JUP CTNND1 ANKAR

1.03e-022223831.25.10.10
DomainEGF_3

LRP1 CELSR1 NOTCH2

1.20e-02235383PS50026
DomainEGF

LRP1 CELSR1 NOTCH2

1.20e-02235383SM00181
PathwayREACTOME_PP2A_MEDIATED_DEPHOSPHORYLATION_OF_KEY_METABOLIC_FACTORS

PPP2CA PPP2CB

1.11e-047332M26992
PathwayREACTOME_REGULATION_OF_CDH19_EXPRESSION_AND_FUNCTION

JUP CTNND1

1.11e-047332M48017
PathwayREACTOME_CDH11_HOMOTYPIC_AND_HETEROTYPIC_INTERACTIONS

JUP CTNND1

1.11e-047332M48038
PathwayREACTOME_REGULATION_OF_CDH11_FUNCTION

JUP CTNND1

1.47e-048332MM17072
PathwayREACTOME_MASTL_FACILITATES_MITOTIC_PROGRESSION

PPP2CA PPP2CB

2.36e-0410332M27176
PathwayREACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1

PPP2CA PPP2CB

2.36e-0410332MM14509
PathwayREACTOME_REGULATION_OF_CDH11_FUNCTION

JUP CTNND1

2.88e-0411332M48015
PathwayREACTOME_REGULATION_OF_GLYCOLYSIS_BY_FRUCTOSE_2_6_BISPHOSPHATE_METABOLISM

PPP2CA PPP2CB

3.46e-0412332M27950
PathwayREACTOME_REGULATION_OF_CDH11_EXPRESSION_AND_FUNCTION

JUP CTNND1

3.46e-0412332MM17071
PathwayREACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1

PPP2CA PPP2CB

4.08e-0413332M1015
PathwayREACTOME_ERKS_ARE_INACTIVATED

PPP2CA PPP2CB

4.08e-0413332MM14811
PathwayWP_DOPAMINE_METABOLISM

PPP2CA PPP2CB

4.08e-0413332M39622
PathwayREACTOME_ERKS_ARE_INACTIVATED

PPP2CA PPP2CB

4.08e-0413332M8410
PathwayREACTOME_SIGNALING_BY_CTNNB1_PHOSPHO_SITE_MUTANTS

PPP2CA PPP2CB

5.47e-0415332M27407
PathwayKEGG_MEDICUS_REFERENCE_COHESIN_DISSOCIATION_IN_PROPHASE

PPP2CA PPP2CB

6.25e-0416332M47870
PathwayREACTOME_DARPP_32_EVENTS

PPP2CA PPP2CB

6.25e-0416332MM14699
PathwayREACTOME_SPRY_REGULATION_OF_FGF_SIGNALING

PPP2CA PPP2CB

6.25e-0416332MM14541
PathwayREACTOME_SPRY_REGULATION_OF_FGF_SIGNALING

PPP2CA PPP2CB

6.25e-0416332M514
PathwayREACTOME_CELL_JUNCTION_ORGANIZATION

FLNA JUP CTNND1

6.50e-0473333MM15126
PathwayREACTOME_PLATELET_SENSITIZATION_BY_LDL

PPP2CA PPP2CB

7.07e-0417332MM15096
PathwayREACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE

PPP2CA PPP2CB

7.07e-0417332M27083
PathwayREACTOME_PLATELET_SENSITIZATION_BY_LDL

PPP2CA PPP2CB

7.07e-0417332M919
PathwayREACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE

PPP2CA PPP2CB

7.94e-0418332MM14759
PathwayKEGG_MEDICUS_REFERENCE_PP2A_AKT_SIGNALING_PATHWAY

PPP2CA PPP2CB

8.86e-0419332M47525
PathwayREACTOME_ERK_MAPK_TARGETS

PPP2CA PPP2CB

8.86e-0419332MM14780
PathwayKEGG_MEDICUS_REFERENCE_CONDENSIN_LOADING

PPP2CA PPP2CB

9.83e-0420332M47876
PathwayREACTOME_CTLA4_INHIBITORY_SIGNALING

PPP2CA PPP2CB

1.09e-0321332M5876
PathwayPID_ECADHERIN_KERATINOCYTE_PATHWAY

JUP CTNND1

1.09e-0321332M184
PathwayREACTOME_CTLA4_INHIBITORY_SIGNALING

PPP2CA PPP2CB

1.09e-0321332MM14996
PathwayREACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION

PPP2CA PPP2CB

1.19e-0322332M6768
PathwayKEGG_MEDICUS_REFERENCE_CD80_CD86_CTLA4_PP2A_SIGNALING_PATHWAY

PPP2CA PPP2CB

1.19e-0322332M47919
PathwayREACTOME_ERK_MAPK_TARGETS

PPP2CA PPP2CB

1.19e-0322332M13408
PathwayWP_ROLES_OF_CERAMIDES_IN_DEVELOPMENT_OF_INSULIN_RESISTANCE

PPP2CA INSR

1.30e-0323332M45533
PathwayREACTOME_DARPP_32_EVENTS

PPP2CA PPP2CB

1.42e-0324332M751
PathwayREACTOME_CELL_CELL_COMMUNICATION

FLNA JUP CTNND1

1.44e-0396333MM14592
PathwayREACTOME_CYCLIN_A_B1_B2_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION

PPP2CA PPP2CB

1.54e-0325332MM15379
PathwayREACTOME_CYCLIN_A_B1_B2_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION

PPP2CA PPP2CB

1.54e-0325332M808
PathwayWP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY

PPP2CA PPP2CB CTNND1

1.67e-03101333MM15829
PathwayWP_WNT_SIGNALING_AND_PLURIPOTENCY

PPP2CA PPP2CB CTNND1

1.67e-03101333M39387
PathwayREACTOME_VEGFR2_MEDIATED_VASCULAR_PERMEABILITY

JUP CTNND1

1.80e-0327332M27422
PathwayREACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION

PPP2CA PPP2CB

1.80e-0327332MM14779
PathwayREACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES

PPP2CA PPP2CB

1.93e-0328332MM15132
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

PPP2CA PPP2CB CACNB3

2.02e-03108333M17034
PathwayREACTOME_NEGATIVE_REGULATION_OF_FGFR3_SIGNALING

PPP2CA PPP2CB

2.07e-0329332M27528
PathwayREACTOME_NEGATIVE_REGULATION_OF_FGFR3_SIGNALING

PPP2CA PPP2CB

2.07e-0329332MM15253
PathwayWP_WNT_SIGNALING_PATHWAY

LRP1 PPP2CA JUP

2.13e-03110333MM15977
PathwayREACTOME_VEGFR2_MEDIATED_VASCULAR_PERMEABILITY

JUP CTNND1

2.22e-0330332MM15170
PathwayREACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK

PPP2CA PPP2CB INSR

2.30e-03113333MM14783
PathwayREACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE

PPP2CA PPP2CB

2.37e-0331332M27400
PathwayREACTOME_NEGATIVE_REGULATION_OF_FGFR4_SIGNALING

PPP2CA PPP2CB

2.37e-0331332M27529
PathwayREACTOME_NEGATIVE_REGULATION_OF_FGFR4_SIGNALING

PPP2CA PPP2CB

2.37e-0331332MM15254
PathwayREACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE

PPP2CA PPP2CB

2.37e-0331332MM15154
PathwayREACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES

PPP2CA PPP2CB

2.37e-0331332M15195
PathwayREACTOME_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION

JUP CTNND1

2.52e-0332332M48012
PathwayREACTOME_CELL_JUNCTION_ORGANIZATION

FLNA JUP CTNND1

2.54e-03117333M19248
PathwayREACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK

PPP2CA PPP2CB INSR

2.60e-03118333M713
PathwayREACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES

PPP2CA PPP2CB JUP CTNND1 INSR

2.68e-03418335MM15587
PathwayREACTOME_NEGATIVE_REGULATION_OF_FGFR1_SIGNALING

PPP2CA PPP2CB

2.68e-0333332M27526
PathwayREACTOME_NEGATIVE_REGULATION_OF_FGFR2_SIGNALING

PPP2CA PPP2CB

2.68e-0333332MM15252
PathwayPID_NCADHERIN_PATHWAY

JUP CTNND1

2.68e-0333332M266
PathwayREACTOME_SIGNALING_BY_WNT_IN_CANCER

PPP2CA PPP2CB

2.84e-0334332M27405
PathwayREACTOME_NEGATIVE_REGULATION_OF_FGFR2_SIGNALING

PPP2CA PPP2CB

2.84e-0334332M27527
PathwayREACTOME_RAF_ACTIVATION

PPP2CA PPP2CB

2.84e-0334332M27556
PathwayWP_GLYCOGEN_METABOLISM

PPP2CA PPP2CB

2.84e-0334332MM15985
PathwayWP_COHESIN_COMPLEX_CORNELIA_DE_LANGE_SYNDROME

PPP2CA PPP2CB

2.84e-0334332M42555
PathwayREACTOME_RAF_ACTIVATION

PPP2CA PPP2CB

3.01e-0335332MM15271
PathwayREACTOME_REGULATION_OF_TP53_DEGRADATION

PPP2CA PPP2CB

3.19e-0336332MM15339
PathwayREACTOME_REGULATION_OF_TP53_EXPRESSION_AND_DEGRADATION

PPP2CA PPP2CB

3.36e-0337332M27641
PathwayREACTOME_SIGNALING_BY_FGFR3

PPP2CA PPP2CB

3.73e-0339332MM15257
PathwayPID_ECADHERIN_NASCENT_AJ_PATHWAY

JUP CTNND1

3.73e-0339332M156
PathwayWP_GLYCOGEN_SYNTHESIS_AND_DEGRADATION

PPP2CA PPP2CB

3.92e-0340332M39595
PathwayREACTOME_SIGNALING_BY_FGFR3

PPP2CA PPP2CB

3.92e-0340332M27532
PathwayREACTOME_SIGNALING_BY_FGFR4

PPP2CA PPP2CB

3.92e-0340332MM15258
PathwayREACTOME_ADHERENS_JUNCTIONS_INTERACTIONS

JUP CTNND1

3.92e-0340332MM15060
PathwayREACTOME_SIGNALING_BY_FGFR4

PPP2CA PPP2CB

4.12e-0341332M27533
PathwayREACTOME_NEGATIVE_REGULATION_OF_MAPK_PATHWAY

PPP2CA PPP2CB

4.32e-0342332MM15274
PathwayREACTOME_NEGATIVE_REGULATION_OF_MAPK_PATHWAY

PPP2CA PPP2CB

4.52e-0343332M27560
PathwayREACTOME_CYCLIN_D_ASSOCIATED_EVENTS_IN_G1

PPP2CA PPP2CB

4.73e-0344332MM15377
PathwayREACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES

PPP2CA PPP2CB FLNA

5.19e-03151333M550
PathwayREACTOME_CYCLIN_D_ASSOCIATED_EVENTS_IN_G1

PPP2CA PPP2CB

5.38e-0347332M29724
PathwayREACTOME_CELL_CELL_COMMUNICATION

FLNA JUP CTNND1

5.59e-03155333M522
PathwayPID_AJDISS_2PATHWAY

JUP CTNND1

5.60e-0348332M142
PathwayREACTOME_CELL_CELL_JUNCTION_ORGANIZATION

JUP CTNND1

5.60e-0348332MM15069
PathwayREACTOME_SIGNALING_BY_FGFR1

PPP2CA PPP2CB

6.07e-0350332MM15255
PathwayREACTOME_SIGNALING_BY_FGFR1

PPP2CA PPP2CB

6.55e-0352332M27530
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

LRP1 CACNB3 CHD1L CTNND1 DPP9 KIF1A INPP5A WNK2 NOTCH2 PPP1R9A ANKAR INSR

3.49e-081489381228611215
Pubmed

Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A.

PPP2CA PPP2CB

1.16e-0623822555176
Pubmed

The role of protein phosphatase 2A catalytic subunit Calpha in embryogenesis: evidence from sequence analysis and localization studies.

PPP2CA PPP2CB

1.16e-06238210543450
Pubmed

Regulation of spindle formation by active mitogen-activated protein kinase and protein phosphatase 2A during mouse oocyte meiosis.

PPP2CA PPP2CB

1.16e-06238211751260
Pubmed

Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities.

PPP2CA PPP2CB

1.16e-06238234902541
Pubmed

Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes.

PPP2CA PPP2CB

1.16e-0623822837763
Pubmed

Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes.

PPP2CA PPP2CB

1.16e-0623821846293
Pubmed

PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte.

PPP2CA PPP2CB

1.16e-06238227096707
Pubmed

Role of a propeller loop in the quaternary structure and enzymatic activity of prolyl dipeptidases DPP-IV and DPP9.

DPP4 DPP9

1.16e-06238222001206
Pubmed

Regional expression of protein phosphatase type 1 and 2A catalytic subunit isoforms in the human heart.

PPP2CA PPP2CB

1.16e-06238211113010
Pubmed

Interaction of filamin A with the insulin receptor alters insulin-dependent activation of the mitogen-activated protein kinase pathway.

FLNA INSR

1.16e-06238212734206
Pubmed

Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.

CCDC50 JUP CTNND1 INSR

1.39e-067538415951569
Pubmed

Isoforms of dipeptidyl aminopeptidase IV from Pseudomonas sp. WO24: role of the signal sequence and overexpression in Escherichia coli.

DPP4 DPP9

3.48e-06338215866709
Pubmed

The effect of CD26-deficiency on dipeptidyl peptidase 8 and 9 expression profiles in a mouse model of Crohn's disease.

DPP4 DPP9

3.48e-06338229693275
Pubmed

The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo.

PPP2CA PPP2CB

3.48e-0633828206937
Pubmed

Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts.

PPP2CA PPP2CB

3.48e-0633827510677
Pubmed

Dipeptidyl peptidases in atherosclerosis: expression and role in macrophage differentiation, activation and apoptosis.

DPP4 DPP9

3.48e-06338223608773
Pubmed

Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway.

LRP1 INSR

3.48e-06338219815552
Pubmed

Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis.

DPP4 DPP9

3.48e-06338216704418
Pubmed

Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2.

PPP2CA PPP2CB

3.48e-06338210441131
Pubmed

Protein phosphatase 2A dephosphorylates CaBP4 and regulates CaBP4 function.

PPP2CA PPP2CB

3.48e-06338223341017
Pubmed

Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively.

PPP2CA PPP2CB

3.48e-0633828383590
Pubmed

Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits.

PPP2CA PPP2CB

3.48e-06338215252037
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

JUP CTNND1 SBF1 NOTCH2 PPP1R9A INSR

6.04e-0642138636976175
Pubmed

The P2Y2 receptor mediates uptake of matrix-retained and aggregated low density lipoprotein in primary vascular smooth muscle cells.

LRP1 FLNA

6.96e-06438227522265
Pubmed

Expression of dipeptidyl peptidase-IV activity and/or structure homologs in human meningiomas.

DPP4 DPP9

6.96e-06438220043068
Pubmed

Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4.

PPP2CA PPP2CB

6.96e-06438211371618
Pubmed

The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.

PPP2CA PPP2CB

6.96e-06438221454489
Pubmed

Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes.

JUP CTNND1

6.96e-0643827876318
Pubmed

The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic.

PPP2CA PPP2CB

6.96e-06438214633983
Pubmed

LRP1 induces anti-PD-1 resistance by modulating the DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage polarisation in bladder cancer.

LRP1 NOTCH2

6.96e-06438238462037
Pubmed

Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse.

PPP2CA PPP2CB

6.96e-06438221998041
Pubmed

Reduced expression of E-cadherin/catenin complex in hepatocellular carcinomas.

JUP CTNND1

6.96e-06438218837082
Pubmed

Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha.

PPP2CA PPP2CB

6.96e-0643829770493
Pubmed

DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk.

FLNA DPP9

6.96e-06438227614019
Pubmed

Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.

PPP2CA PPP2CB

6.96e-0643827616230
Pubmed

Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain.

PPP2CA PPP2CB

6.96e-0643829920888
Pubmed

Epithelial cells as phagocytes: apoptotic epithelial cells are engulfed by mammary alveolar epithelial cells and repress inflammatory mediator release.

LRP1 JMJD6

6.96e-06438215647754
Pubmed

Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia.

JUP CTNND1

1.16e-0553827542250
Pubmed

The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin.

JUP CTNND1

1.16e-0553827651399
Pubmed

N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane.

JUP CTNND1

1.16e-05538212604612
Pubmed

Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain.

PPP2CA PPP2CB

1.16e-05538210640627
Pubmed

Expression and prognostic assessment of dipeptidyl peptidase IV and related enzymes in B-cell chronic lymphocytic leukemia.

DPP4 DPP9

1.16e-05538220534982
Pubmed

Expression and interaction of different catenins in colorectal carcinoma cells.

JUP CTNND1

1.16e-05538211712088
Pubmed

Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver.

DPP4 DPP9

1.16e-05538223704821
Pubmed

Trim32 reduces PI3K-Akt-FoxO signaling in muscle atrophy by promoting plakoglobin-PI3K dissociation.

JUP INSR

1.16e-05538224567360
Pubmed

HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint.

PPP2CA PPP2CB

1.16e-0553829009195
Pubmed

Protein phosphatase 2A interacts with and directly dephosphorylates RelA.

PPP2CA PPP2CB

1.16e-05538211591705
Pubmed

Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice.

PPP2CA PPP2CB

1.16e-05538218596935
Pubmed

Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development.

PPP2CA PPP2CB

1.74e-05638210781942
Pubmed

Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A.

PPP2CA PPP2CB

1.74e-05638220100830
Pubmed

Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis.

PPP2CA PPP2CB

1.74e-05638229735529
Pubmed

Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex.

JUP CTNND1

1.74e-05638211226248
Pubmed

Protein phosphorylation of human brain glutamic acid decarboxylase (GAD)65 and GAD67 and its physiological implications.

PPP2CA PPP2CB

1.74e-05638215147202
Pubmed

STRIPAK components determine mode of cancer cell migration and metastasis.

PPP2CA PPP2CB

1.74e-05638225531779
Pubmed

Alpha 4 associates with protein phosphatases 2A, 4, and 6.

PPP2CA PPP2CB

1.74e-0563829647778
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

PPP2CB FLNA JUP CTNND1 SBF1 WNK2 PPP1R9A EIF3L NUAK2

1.82e-05143138937142655
Pubmed

The ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development.

PPP2CA PPP2CB

2.43e-05738225546391
Pubmed

X-linked microtubule-associated protein, Mid1, regulates axon development.

PPP2CA PPP2CB

2.43e-05738224194544
Pubmed

GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin.

PPP2CA PPP2CB

2.43e-05738210698523
Pubmed

Protein phosphatase 2A and separase form a complex regulated by separase autocleavage.

PPP2CA PPP2CB

2.43e-05738217604273
Pubmed

Gamma-secretase-dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activity.

JUP CTNND1

2.43e-05738219114997
Pubmed

The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn).

JUP CTNND1

2.43e-05738212370829
Pubmed

Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data.

PPP2CA PPP2CB FLNA

2.56e-055238326499835
Pubmed

Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.

CTNND1 SBF1 KIF1A NOTCH2

2.82e-0516038431678930
Pubmed

Claudin-4 localization in epithelial ovarian cancer.

JUP CTNND1 NOTCH2

2.87e-055438336237976
Pubmed

p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected].

PPP2CA PPP2CB

3.24e-0583821330687
Pubmed

Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A.

PPP2CA PPP2CB

3.24e-05838212912990
Pubmed

Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy.

PPP2CA PPP2CB

3.24e-05838235768646
Pubmed

Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution.

PPP2CA PPP2CB

3.24e-05838212370081
Pubmed

The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton.

JUP CTNND1

3.24e-0583829535896
Pubmed

Type 2A protein phosphatase, the complex regulator of numerous signaling pathways.

PPP2CA PPP2CB

3.24e-05838211007961
Pubmed

Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation.

PPP2CA PPP2CB

3.24e-05838216262633
Pubmed

Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons.

PPP2CA PPP2CB

3.24e-05838223462102
Pubmed

Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.

PPP2CA PPP2CB

4.16e-05938218432318
Pubmed

Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2.

PCDH15 NOTCH2

4.16e-05938223144817
Pubmed

The role of notch signaling in the development of intrahepatic bile ducts.

DPP4 NOTCH2

4.16e-05938215578515
Pubmed

Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital.

PPP2CA PPP2CB

4.16e-05938212885400
Pubmed

Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.

PPP2CA FLNA

4.16e-05938211114196
Pubmed

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.

TUBGCP6 PPP2CA PPP2CB CHD1L CTNND1 DPP9

4.69e-0560638636538041
Pubmed

A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells.

JUP CTNND1

6.35e-051138214625392
Pubmed

Igf1r signaling is indispensable for preimplantation development and is activated via a novel function of E-cadherin.

JUP CTNND1

6.35e-051138222479204
Pubmed

MARF1 regulates essential oogenic processes in mice.

PPP2CA PPP2CB

6.35e-051138222442484
Pubmed

Streamlined analysis schema for high-throughput identification of endogenous protein complexes.

INTS6L PPP2CA PPP2CB

6.53e-057138320133760
Pubmed

Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5.

PPP2CA PPP2CB

7.62e-051238212435421
Pubmed

Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT).

JUP CTNND1

7.62e-051238216973135
Pubmed

Regulation of cochlear convergent extension by the vertebrate planar cell polarity pathway is dependent on p120-catenin.

PCDH15 CTNND1

7.62e-051238222318628
Pubmed

Defining desmosomal plakophilin-3 interactions.

JUP CTNND1

7.62e-051238212707304
Pubmed

Two immunologically distinct human DNA polymerase alpha-primase subpopulations are involved in cellular DNA replication.

PPP2CA PPP2CB

7.62e-051238211259605
Pubmed

PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation.

PPP2CA PPP2CB

7.62e-051238234079065
Pubmed

The ins and outs of HIV-1 Tat.

LRP1 DPP4

7.62e-051238221951552
Pubmed

PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum.

PPP2CA PPP2CB

9.00e-051338216717086
Pubmed

Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29.

PPP2CA PPP2CB

9.00e-051338218971272
Pubmed

PP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins.

PPP2CA PPP2CB

9.00e-051338221072166
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

LRP1 DPP4 SBF1 KIF1A INSR

9.07e-0542038528065597
Pubmed

Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr.

PPP2CA PPP2CB

1.05e-04143829013886
Pubmed

Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects.

JUP CTNND1

1.05e-041438217766470
Pubmed

Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production.

PPP2CA PPP2CB

1.05e-04143829400615
Pubmed

Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development.

JUP CTNND1

1.21e-041538218393386
Pubmed

Deletion of Sarcolemmal Membrane-Associated Protein Isoform 3 (SLMAP3) in Cardiac Progenitors Delays Embryonic Growth of Myocardium without Affecting Hippo Pathway.

PPP2CA PPP2CB

1.21e-041538238474134
InteractionTAFA3 interactions

PPP2CA DPP9 KIF1A INSR

1.39e-0578384int:TAFA3
InteractionPPP1R9B interactions

PPP2CA DPP4 PPP2CB FLNA JUP CACNB3 PPP1R9A NUAK2

1.78e-05626388int:PPP1R9B
InteractionSRC interactions

LRP1 DPP4 PPP2CB FLNA JUP CTNND1 EFS INSR

2.71e-05664388int:SRC
InteractionGAD1 interactions

PPP2CA PPP2CB JMJD6

4.60e-0537383int:GAD1
InteractionCAV1 interactions

LRP1 PPP2CA FLNA JUP CTNND1 NOTCH2 PPP1R9A INSR

5.02e-05724388int:CAV1
InteractionINTS6 interactions

INTS6L LRP1 PPP2CA PPP2CB

5.38e-05110384int:INTS6
InteractionWNT3A interactions

LRP1 NOTCH2 INSR

1.07e-0449383int:WNT3A
InteractionFOXD4L6 interactions

TUBGCP6 PPP2CA NOTCH2

1.07e-0449383int:FOXD4L6
CytobandEnsembl 112 genes in cytogenetic band chr22q13

TUBGCP6 CELSR1 SBF1 EIF3L

1.60e-04330384chr22q13
Cytoband12p13.3

ANO2 PRMT8

2.86e-043038212p13.3
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

JUP CTNND1 ANKAR

3.94e-0543283409
GeneFamilyCD molecules|DASH family

DPP4 DPP9

4.83e-0572821205
GeneFamilyProtein phosphatase catalytic subunits|EF-hand domain containing

PPP2CA PPP2CB

1.79e-0413282693
GeneFamilyProtein phosphatase catalytic subunits|STRIPAK complex

PPP2CA PPP2CB

4.32e-04202821371
GeneFamilyActins|Deafness associated genes

PCDH15 CCDC50

1.32e-021132821152
GeneFamilyADAM metallopeptidase domain containing|CD molecules

LRP1 DPP4 INSR

2.25e-02394283471
GeneFamilyFibronectin type III domain containing

MYOM1 INSR

2.53e-02160282555
CoexpressionGSE21774_CD62L_POS_CD56_DIM_VS_CD62L_NEG_CD56_DIM_NK_CELL_UP

INTS6L CELSR1 MYOM1 INPP5A INSR

9.82e-06199385M7491
ToppCellBronchial_Biopsy-Epithelial-Club|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

DPP4 WNK2 NOTCH2 PPP1R9A INSR

6.66e-07196385057d150bdf0cad959fd03ec2d1560a96ba03fae9
ToppCellBronchial_Biopsy-Epithelial-Club|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

DPP4 WNK2 NOTCH2 PPP1R9A INSR

6.83e-071973853f5dfa892a1f631b96eeb6f4cfc284aee51d1ce6
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA MYOM1 AEBP1 WNK2

1.41e-05173384fc2602b2ce051cd4c33957d7e3d041ff8a529883
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA MYOM1 AEBP1 WNK2

1.41e-05173384901b8e6909c1f3849906fad9cee17b8f0bab050d
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_activate-7|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

JUP LAT2 INPP5A NUAK2

1.51e-05176384dde46f06f6fc3f7ba83be91a0ee6231790955e3e
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

CELSR1 PRMT8 WNK2 PPP1R9A

1.83e-05185384cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellAdult-Epithelial-club_cell-D231|Adult / Lineage, Cell type, age group and donor

CELSR1 PRMT8 WNK2 INSR

1.91e-05187384ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-B_cell-B_cell|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CCDC50 JUP CELSR1 NUAK2

1.95e-0518838499fdd305f75ed38dd507e7a17ffe27c26b86e454
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-B_cell|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CCDC50 JUP CELSR1 NUAK2

1.95e-051883845a0519b189e96001d95f9d24363448e8602b8d4d
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-B_cell-B_cell-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CCDC50 JUP CELSR1 NUAK2

1.95e-05188384e8b7c1c2eb2e390ad79b358236468b0f15ea58a5
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA MYOM1 INPP5A WNK2

1.99e-051893847fbe855bfdb47d35e040b04a80fe4b729a3764e8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA MYOM1 INPP5A WNK2

1.99e-0518938406b35abecd29f902cf251fcc1f6ad33db7ab08a2
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA MYOM1 INPP5A WNK2

1.99e-05189384127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCellCOVID-19-lung-Secretory|lung / Disease (COVID-19 only), tissue and cell type

CELSR1 WNK2 PPP1R9A INSR

1.99e-0518938484d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA MYOM1 INPP5A WNK2

1.99e-051893842cfb4d12f75678d1619f4743838a0e954bd57761
ToppCellAdult-Epithelial-club_cell|Adult / Lineage, Cell type, age group and donor

CELSR1 PRMT8 WNK2 INSR

2.03e-05190384756bff697d30aec56c0ebfca94295f084a15bf37
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA MYOM1 INPP5A WNK2

2.08e-051913848e8beb8e8a3b33cac83d3f7ce915a71e3654fdab
ToppCellControl-Stromal_mesenchymal|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCDH15 LRP1 AEBP1 NOTCH2

2.08e-0519138414057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCellfacs-Lung-EPCAM-18m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 FLNA AEBP1 NOTCH2

2.16e-05193384b9ac74357435f2f24aaede62b2a1d31b5d96a12c
ToppCellEpithelial-club_cell|World / Lineage, Cell type, age group and donor

CELSR1 PRMT8 WNK2 PPP1R9A

2.16e-051933842bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCellnucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

JUP CELSR1 WNK2 INSR

2.21e-051943840cd4363627acd419e00d6d32f6dce10430aa6487
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LRP1 DPP4 PPP2CB AEBP1

2.21e-0519438408fad7591c20568de797cf8e206de2d0b1d78aab
ToppCell10x5'v1-week_14-16-Lymphocytic_B-B_lineage-naive_B_cell|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

JUP AEBP1 LAT2 NUAK2

2.21e-051943844a4cc61193344bb151439f63d0584abddde47cf0
ToppCellnucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS-RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

JUP CELSR1 WNK2 INSR

2.21e-05194384a58841b34efe673671a9a059238e044a7254b279
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA MYOM1 INPP5A WNK2

2.21e-05194384b8a130ffae68ffe550bf335460a1ec1035cf8d8d
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DPP4 CELSR1 WNK2 INSR

2.25e-051953842a9a36df1dbc4eac77a8ddbe939ec8a8d6c41464
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 FLNA AEBP1 HEPH

2.25e-0519538449c99553629cdd83ee56a2e508d5bc8d34b8507b
ToppCellCOVID-19-Heart-CM_2|Heart / Disease (COVID-19 only), tissue and cell type

MYOM1 WNK2 PPP1R9A INSR

2.25e-0519538475fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DPP4 CELSR1 WNK2 INSR

2.25e-05195384576142b4e75457c0973051bccc4163bd624496af
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 FLNA AEBP1 HEPH

2.25e-05195384dd281a249854800f737dc22e0f375f66dfb5cf5f
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DPP4 CELSR1 WNK2 INSR

2.25e-051953848f151066ad3ebd9661ea0b733f03c2ce1518f9ad
ToppCellIIH-mDC2-|IIH / Condition, Cell_class and T cell subcluster

CCDC50 CTNND1 LAT2 INSR

2.25e-05195384ed4fcd51d523d960bf3650bf284d400007e55714
ToppCellIIH-mDC2|IIH / Condition, Cell_class and T cell subcluster

CCDC50 CTNND1 LAT2 INSR

2.25e-051953844146912b69041cc1505ddba4125c8e10e0125329
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA MYOM1 AEBP1 WNK2

2.30e-051963841522958a92e0126326a9f0d9fb1c5b5c50b001ea
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DPP4 CELSR1 WNK2 INSR

2.30e-051963848e909c31733762646359fe78b645cbd60237459e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA MYOM1 AEBP1 WNK2

2.30e-051963841c8294014713684b50885e638668f2ce75f357f0
ToppCellVE-mDC2-|VE / Condition, Cell_class and T cell subcluster

CCDC50 CTNND1 LAT2 INSR

2.34e-051973846629588819ec31a7e4f33b94b8c035145a5f6c17
ToppCellVE-mDC2|VE / Condition, Cell_class and T cell subcluster

CCDC50 CTNND1 LAT2 INSR

2.34e-05197384e3172102ad17c92c3038cad37bf933eb04351048
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CELSR1 PRMT8 WNK2 INSR

2.39e-05198384af399569c718f5fd971d73a7926768c9311002a3
ToppCellTracheal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FLNA MYOM1 AEBP1 IRX4

2.44e-051993848ff0fdcbe9661b013913731ec8b53d84836ca865
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PCDH15 LRP1 CCDC50 PPP1R9A

2.44e-0519938419a97e27a4758e794ce7246d295e112b47931a48
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors|1_mon / Sample Type, Dataset, Time_group, and Cell type.

PPP2CB CELSR1 NOTCH2 NUAK2

2.44e-05199384358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_monocytic-monocyte|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CTNND1 ALOX15B INSR

1.64e-04125383a72891c3fb9cdefa9254f8e2e3c4ffa6fc3a5ffc
ToppCell390C-Lymphocytic-NK_cells-NK_cell_D|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CELSR1 LAT2 INSR

2.39e-04142383e5608bbbc04edcdaafe1affc4db7f9d8edba04d9
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

PCDH15 CCDC50 PRMT8

2.50e-04144383fca32b38d23fa4d213e553b929604a2796e9a929
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCDH15 WNK2 ANKAR

2.55e-0414538396712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MYOM1 ALOX15B NUAK2

2.76e-04149383a85a051e0d82430160967e72fa04b55f43e84513
ToppCellPericytes-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

AEBP1 EFS HEPH

2.81e-04150383dbc202bd6db4fb5c8b2abd1200e074a2a9e63a59
ToppCellHealthy_donor-B_cell|World / disease group, cell group and cell class (v2)

CELSR1 INPP5A PPP1R9A

2.81e-04150383a2dfed562de7f58f902b547acec5a13853c80c4c
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MYOM1 ALOX15B NUAK2

2.81e-041503837a381f5ae94eba5eb60dcbf83416b4eb18c279ea
ToppCellLeuk-UTI-Lymphocyte-T_NK-MAIT|Leuk-UTI / Disease, Lineage and Cell Type

DPP4 GPR15 PPP1R9A

2.98e-04153383ac3a1d1b5bf6009df818fd757dad7382d95c60dc
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-midbrain/hindbrain_cells|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

ANO2 LHX5 IRX4

3.04e-04154383df1b58a20af73fa79c6c069c0117a9ffd85b476f
ToppCellE16.5-Immune-Immune_Myeloid-Granulocytic|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GPR15 LAT2 ALOX15B

3.10e-04155383c648512305166d2a2f0e284c127bc802af908071
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PCDH15 CCDC50 PPP1R9A

3.10e-0415538377fdae85d36efb776db977eb424b32487ef222e4
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA MYOM1 AEBP1

3.16e-04156383d5207dbfbcfb885557ea1378dfe6a56d7102e94a
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA MYOM1 AEBP1

3.16e-04156383363f1b661048d25895e2b8681c82894c957b29c0
ToppCell3'_v3-bone_marrow-Lymphocytic_B-Pro-B|bone_marrow / Manually curated celltypes from each tissue

JUP AEBP1 LAT2

3.16e-04156383b093dbba6662e4fffc8aa577587b77f64ac44b56
ToppCellfacs-Lung-EPCAM-3m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 NOTCH2 NUAK2

3.28e-04158383b0508a600994090c6aafd8d779437190a33ad821
ToppCellfacs-Lung-EPCAM-3m-Myeloid-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 NOTCH2 NUAK2

3.28e-04158383ef5feb48161c339c7b71c576bdda61479d29dfac
ToppCellfacs-Lung-EPCAM-3m-Myeloid-Classical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 NOTCH2 NUAK2

3.28e-04158383c6e64b9b3342e37d54baadae8fb7dfb5d246e4cf
ToppCellfacs-Lung-EPCAM-3m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 NOTCH2 NUAK2

3.28e-04158383a816cc095452308d06f87b77467e2a8c6361fd2a
ToppCellLPS-IL1RA-Stromal_mesenchymal-Fibroblasts-MatrixFB_->_Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AEBP1 EFS INSR

3.40e-04160383778faada072e3abfa76a9a06fd4885fb63de7902
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CELSR1 WNK2 INSR

3.46e-041613832d63b279d9a5132e1c09b03930bf9039036d24a2
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCDH15 WNK2 ANKAR

3.52e-04162383bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellBronchial-10x5prime-Stromal-Schwann|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

KIF1A HEPH PPP1R9A

3.52e-04162383afffecc6c504930554aafc12c5bffa53e3c5b016
ToppCellClub_cells-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

CELSR1 KIF1A WNK2

3.65e-041643834e25e6362ef793b08de2f4d1dccb6b1fc9c072a5
ToppCellfacs-MAT-Fat-24m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELSR1 ANKAR ALOX15B

3.65e-04164383e9e34c305c943675688e54ab331c2bdefb2fac68
ToppCellPCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CELSR1 PRMT8 PPP1R9A

3.72e-041653830c714e852f912b5749de4cb0895406673979b2e6
ToppCellPCW_07-8.5-Epithelial-Epithelial_ciliated|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CELSR1 PRMT8 PPP1R9A

3.72e-0416538382530f96aaefe28a13bad0474bbad043f127a86c
ToppCellwk_15-18-Epithelial-Airway_epithelial_progenitor-epi-prox-progenitor_intermediate_|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CELSR1 WNK2 NUAK2

3.72e-04165383f6887c64af0f26e33316bc5587487e24d76ece2a
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DPP4 WNK2 INSR

3.78e-0416638360060b03f2abfa3cc08107ab5a9f578e60e4ae16
ToppCellsevere-Myeloid-pDC|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

CCDC50 DPP4 AEBP1

3.78e-04166383ae38850fde549b8dd6fb12f0ef80b428ade50485
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DPP4 WNK2 INSR

3.78e-04166383ec9161d388db5a257b8d125c14f9dd911d5d5d4a
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DPP4 WNK2 INSR

3.78e-041663834586d6725403f879fc96f67be579022587ce1906
ToppCell3'_v3-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-ILC3|GI_small-bowel / Manually curated celltypes from each tissue

JUP IRX4 PPP1R9A

3.78e-04166383773673a5d0430640439845b264740bfbbdad0cb2
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLNA MYOM1 AEBP1

3.85e-04167383784776d1fcc098f84d3c2eca58fa56cb9428f434
ToppCell3'_v3-GI_small-bowel-Lymphocytic_Invariant-Inducer-like|GI_small-bowel / Manually curated celltypes from each tissue

JUP IRX4 PPP1R9A

3.85e-041673833ae46c6363da76c8e1f5579e6027bf88ed637a44
ToppCellfacs-Lung-24m-Hematologic-myeloid-non-classical_monocyte|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRP1 FLNA NUAK2

3.92e-04168383c861f80aa12caf54a94d93e38539ff41dc5227a6
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CELSR1 WNK2 INSR

3.99e-0416938340b557549fe08c5dc9dba359af35993d68d1640a
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCDH15 MYOM1 AEBP1

3.99e-0416938312bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellfacs-Heart-RV-18m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 DPP4 AEBP1

4.06e-04170383d7c9a604311974ff87ece43a0f8725a234d262f7
ToppCell368C-Myeloid-Dendritic-pDC|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

CCDC50 DPP4 MYOM1

4.13e-04171383714a0b0d0c9886fef64170cf53eb64f0d8a47280
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYOM1 AEBP1 NOTCH2

4.13e-041713834ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCelldroplet-Pancreas-Exocrine|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA AEBP1 NOTCH2

4.13e-0417138392ac4cc3d54da2ea8e202aa59c78e8875356649e
ToppCellfacs-BAT-Fat-18m-Myeloid-nan|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 FLNA NUAK2

4.20e-0417238336fe66a8c0aecee7a19269be23210c0ed7abb155
ToppCell10x3'2.3-week_12-13-Lymphocytic_NK-T_NK-NK_progenitor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

DPP4 CACNB3 PRMT8

4.20e-04172383a126dacd94939851de1403d30f0b63eaad48bfa1
ToppCellfacs-Lung-EPCAM-18m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNB3 LHX5 KIF1A

4.20e-04172383c5caae0b21e35a2d5dcd898fbfa1ef33f92c019f
ToppCellfacs-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNB3 LHX5 KIF1A

4.20e-0417238348d0cfc37d1b1ae48ed8f8b2711abeb609d2bb6e
ToppCellfacs-Lung-EPCAM-18m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNB3 LHX5 KIF1A

4.20e-041723837c085c02b59e24e2a2cd393b5e692f9fb19257fe
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INTS6L FLNA MYOM1

4.27e-041733832415b6ff49f334da570577d4e93484d024a3dbd5
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INTS6L LAT2 ALOX15B

4.27e-041733833612772632ddf11eb48579cae9a8ccab6b3f1f52
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INTS6L FLNA MYOM1

4.27e-041733832acd0693a2dfe04e3c1b2125ea63efe92d13150b
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INTS6L LAT2 ALOX15B

4.27e-041733834dc261ebcdb9bdcfca1451da1bd254f0dc5de203
ToppCellcritical-Epithelial-unknown_epithelial|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

FLNA LAT2 JMJD6

4.27e-041733834144b1cdefa8c37b6ac7a6d249fa5292ffb2b8b2
ToppCellE16.5-Immune-Immune_Myeloid-Granulocytic-Basophil|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GPR15 LAT2 ALOX15B

4.27e-041733832cba41c3d9d3076f703115d19729073a3ac3feb6
ToppCellE16.5-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GPR15 LAT2 ALOX15B

4.27e-0417338311d69a4ab4a87b8820cd3bd204de8c4124450a90
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCDH15 CELSR1 PPP1R9A

4.34e-04174383e2243f1e48e3275753a2b3a69d06eefce69a8ded
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC50 LAT2 NOTCH2

4.34e-041743832f4bc0275cbcaa830d04a4c76e042456908d2277
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP1 FLNA CHD1L

4.34e-04174383d5c22b43531414951666ee7542a66ed9380e2d14
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC50 LAT2 NOTCH2

4.34e-0417438301eff218e71a04201189a0313aaf91437fffed95
DrugC5-substituted pyrrolidine 31

DPP4 DPP9

2.57e-062372CID010339570
DrugSureCN3749646

DPP4 DPP9

7.70e-063372CID011530920
DrugSureCN3745540

DPP4 DPP9

7.70e-063372CID011974437
DrugSureCN3749947

DPP4 DPP9

7.70e-063372CID011974435
DrugAdenosine-5'-[Beta, Gamma-Methylene]Triphosphate

KIF1A INSR

7.70e-063372DB03909
DrugABT-279

DPP4 DPP9

7.70e-063372CID016049769
DrugCyanopyrrolidine 38

DPP4 DPP9

7.70e-063372CID010932707
DrugCyanopyrrolidine 39

DPP4 DPP9

7.70e-063372CID011117606
DrugSureCN3748611

DPP4 DPP9

7.70e-063372CID011974325
DrugDiprolyl-alanine

DPP4 DPP9

7.70e-063372CID000193559
Drug2-propylpentanoic acid; Up 200; 200uM; HL60; HT_HG-U133A

LRP1 DPP4 CACNB3 CELSR1 PPP1R9A

1.49e-051943756173_UP
DrugMedrysone [2668-66-8]; Up 200; 11.6uM; HL60; HT_HG-U133A

LRP1 DPP4 PRMT8 EFS IRX4

1.53e-051953752544_UP
Drugglycylproline 4-nitroanilide

DPP4 DPP9

1.54e-054372ctd:C042892
DrugCefuroxime sodium salt [56238-63-2]; Down 200; 9uM; HL60; HT_HG-U133A

JUP CACNB3 CTNND1 SBF1 JMJD6

1.60e-051973752526_DN
DrugMinoxidil [38304-91-5]; Up 200; 19.2uM; MCF7; HT_HG-U133A

DPP4 CHD1L CTNND1 LAT2 NOTCH2

1.60e-051973754800_UP
Drugprodipine

DPP4 DPP9

2.56e-055372CID000065775
Drugarginyl(PMC)-pyrrolidine-2-nitrile

DPP4 DPP9

2.56e-055372CID000487437
Drugalanylproline-4-nitroanilide

DPP4 DPP9

2.56e-055372ctd:C083013
Drugcathepsin C substrate

DPP4 DPP9

3.84e-056372CID003508173
DrugNVP-DPP728

DPP4 DPP9

3.84e-056372CID009796290
DrugMK-251

DPP4 DPP9

3.84e-056372CID000176160
DrugII 19

DPP4 DPP9

3.84e-056372CID000040321
DrugAC1L1UOE

DPP4 DPP9 NOTCH2

4.04e-0541373CID000010191
DrugEpostatin

DPP4 DPP9

5.37e-057372CID006449105
Drugo-Py

DPP4 DPP9

5.37e-057372CID009942336
DrugCID6451162

DPP4 DPP9

7.15e-058372CID006451162
DrugP32/98

DPP4 DPP9

7.15e-058372CID006918464
Drugimidazolelactate

DPP4 DPP9

7.15e-058372CID000000793
DrugNSC-334212

DPP4 DPP9

9.18e-059372CID000333414
DrugGly-pro-na

DPP4 DPP9

9.18e-059372CID000194319
DrugAppna

DPP4 DPP9

9.18e-059372CID006453929
DrugPhe-pro-ala

DPP4 DPP9

9.18e-059372CID000133668
DrugSureCN475872

DPP4 DPP9

9.18e-059372CID011163584
DrugManganese

DPP4 CELSR1 MYOM1 LAT2 HEPH INSR

1.14e-04480376ctd:D008345
DrugN-phenylphthalimide

DPP4 DPP9

1.15e-0410372CID000068215
DrugVitamin E

PPP2CA PPP2CB

1.15e-0410372DB00163
DrugHxp

DPP4 DPP9

1.15e-0410372CID000449159
DrugX1043

DPP4 DPP9

1.15e-0410372CID011235728
DrugPMSA

DPP4 FLNA

1.40e-0411372CID000125605
DrugKiq

DPP4 DPP9

1.98e-0413372CID011974439
Drugsampatrilat

DPP4 DPP9

1.98e-0413372CID006324648
Drug4-nitroaniline

DPP4 DPP9

1.98e-0413372ctd:C019498
DrugUCF 101

PPP2CA PPP2CB

1.98e-0413372ctd:C501517
DrugGly-pro-mca

DPP4 DPP9

1.98e-0413372CID000125640
DrugAC1MHZPD

DPP4 DPP9

2.31e-0414372CID003035635
Drug7-amino-4-trifluoromethylcoumarin

DPP4 DPP9

2.31e-0414372CID000100641
Drug1-undecanol

EFS ALOX15B

2.31e-0414372CID000008184
DrugAC1L4NWK

DPP4 DPP9

2.66e-0415372CID000189017
DrugAC1L322F

DPP4 DPP9

2.66e-0415372CID000133040
DrugAlsterpaullone; Up 200; 10uM; MCF7; HT_HG-U133A

SBF1 KIF1A LAT2 JMJD6

2.71e-041943747051_UP
DrugRapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A

GPR15 KIF1A LAT2 INSR

2.76e-041953746967_UP
DrugFenoprofen calcium salt dihydrate [53746-45-5]; Up 200; 7.2uM; MCF7; HT_HG-U133A

DPP4 LAT2 PPP1R9A INSR

2.76e-041953744736_UP
DrugPropoxycaine hydrochloride [550-83-4]; Up 200; 12uM; PC3; HT_HG-U133A

CACNB3 KIF1A JMJD6 NUAK2

2.82e-041963747155_UP
DrugPF-00539745-00 [351321-33-0]; Up 200; 10uM; MCF7; HT_HG-U133A

KIF1A LAT2 NOTCH2 PPP1R9A

2.87e-041973745974_UP
DrugLY 294002; Down 200; 0.1uM; MCF7; HT_HG-U133A

CACNB3 CELSR1 KIF1A IRX4

2.87e-041973746935_DN
DrugKetoconazole [65277-42-1]; Up 200; 7.6uM; MCF7; HT_HG-U133A

PPP2CB ANO2 CELSR1 PPP1R9A

2.87e-041973745685_UP
DrugPropidium iodide [25535-16-4]; Up 200; 6uM; PC3; HT_HG-U133A

KIF1A LAT2 ALOX15B INSR

2.87e-041973745803_UP
Drug(R)-(+)-Atenolol [56715-13-0]; Up 200; 15uM; MCF7; HT_HG-U133A

DPP4 GPR15 LAT2 EFS

2.93e-041983744841_UP
DrugIfosfamide [3778-73-2]; Up 200; 15.4uM; PC3; HT_HG-U133A

ANO2 GPR15 IRX4 ALOX15B

2.93e-041983745805_UP
DrugChlorambucil [305-03-3]; Up 200; 13.2uM; PC3; HT_HG-U133A

PPP2CB LAT2 INSR NUAK2

2.93e-041983743788_UP
DrugYohimbine hydrochloride [65-19-0]; Up 200; 10.2uM; PC3; HT_HG-U133A

CACNB3 SBF1 KIF1A NUAK2

2.93e-041983747130_UP
DrugCefadroxil [50370-12-2]; Down 200; 11uM; MCF7; HT_HG-U133A

CACNB3 SBF1 KIF1A JMJD6

2.93e-041983743259_DN
DrugPractolol [6673-35-4]; Up 200; 15uM; PC3; HT_HG-U133A

ANO2 PRMT8 HEPH ALOX15B

2.93e-041983744603_UP
DrugHexamethonium dibromide dihydrate [55-97-0]; Down 200; 10uM; MCF7; HT_HG-U133A

CHD1L CTNND1 SBF1 KIF1A

2.93e-041983741482_DN
Drugvinblastine sulfate; Down 200; 0.1uM; PC3; HT_HG-U133A

DPP4 CACNB3 CHD1L SBF1

2.93e-041983747556_DN
DrugGliquidone [33342-05-1]; Up 200; 7.6uM; MCF7; HT_HG-U133A

LRP1 SBF1 LAT2 JMJD6

2.98e-041993746505_UP
DrugTriamcinolone [124-94-7]; Down 200; 10.2uM; MCF7; HT_HG-U133A

CACNB3 CTNND1 SBF1 IRX4

2.98e-041993747192_DN
Drug9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2; Down 200; 10uM; MCF7; HT_HG-U133A

CACNB3 AEBP1 IRX4 NOTCH2

2.98e-041993747552_DN
DrugSkimmianine [83-95-4]; Up 200; 15.4uM; PC3; HT_HG-U133A

ANO2 PRMT8 KIF1A LAT2

2.98e-041993745766_UP
DrugCromolyn disodium salt [15826-37-6]; Up 200; 7.8uM; PC3; HT_HG-U133A

LRP1 CACNB3 GPR15 KIF1A

2.98e-041993745754_UP
DrugChlorine

PPP2CA DPP4 PPP2CB JUP CACNB3

3.02e-04367375ctd:D002713
DrugFLEC

DPP4 EFS

3.04e-0416372CID000115102
DrugPHA-00851261E [724719-49-7]; Up 200; 1uM; MCF7; HT_HG-U133A

ANO2 LAT2 JMJD6 HEPH

3.04e-042003743968_UP
DrugFoliosidine [2520-38-9]; Up 200; 13uM; MCF7; HT_HG-U133A

PPP2CB ANO2 GPR15 LAT2

3.04e-042003746057_UP
DrugIobenguane sulfate; Up 200; 10.8uM; MCF7; HT_HG-U133A

DPP4 SBF1 ALOX15B INSR

3.04e-042003746002_UP
DrugSpectinomycin dihydrochloride [21736-83-4]; Up 200; 9.8uM; HL60; HT_HG-U133A

LRP1 DPP4 GPR15 IRX4

3.04e-042003742987_UP
DrugPanthenol (D) [81-13-0]; Up 200; 19.4uM; MCF7; HT_HG-U133A

PPP2CB SBF1 KIF1A LAT2

3.04e-042003747455_UP
DrugPalmatine chloride [3486-67-7]; Down 200; 10.4uM; PC3; HT_HG-U133A

KIF1A NOTCH2 INSR NUAK2

3.04e-042003746612_DN
DrugArg-pro

DPP4 DPP9 INSR

3.20e-0482373CID000151003
Drugpyrrolidinium

DPP4 DPP9 NOTCH2

3.56e-0485373CID000031268
Drugl-alanyl-l-proline

DPP4 CHD1L DPP9

3.81e-0487373CID000083525
Drugeuropium

FLNA HEPH INSR

3.81e-0487373CID000023981
Drugcoproporphyrin I

DPP4 DPP9

3.87e-0418372CID000068271
DrugHis-Ser

DPP4 DPP9

3.87e-0418372CID000435727
Drug4,4'-DBP

JUP SBF1

4.32e-0419372CID000007034
Drugbeta-methylphenylalanine

DPP4 DPP9

5.29e-0421372CID000064808
Drug26 C

DPP4 DPP9

5.29e-0421372CID005327159
Drugbeta-Casomorphin 4

DPP4 DPP9

5.29e-0421372CID000173253
Drugdiphenyl phosphonate

DPP4 DPP9

5.29e-0421372CID006327546
DrugTrp-Ala

DPP4 DPP9

6.36e-0423372CID000263475
Drugtosylate

DPP4 DPP9

6.36e-0423372CID000006101
Drugphaeophytin-a

CACNB3 EFS HEPH

6.61e-04105373CID005351507
DrugAC1L320U

PPP2CA PPP2CB

7.53e-0425372CID000133020
Drug5-nitrosalicylaldehyde

DPP4 DPP9

7.53e-0425372CID000066808
Drugmanganese chloride

DPP4 CELSR1 MYOM1 HEPH INSR

8.10e-04456375ctd:C025340
DrugB-Ms

DPP4 EFS NOTCH2

8.39e-04114373CID000445091
DrugArg-pro-pro

DPP4 DPP9

8.79e-0427372CID000152660
DrugDeprolorphin

DPP4 DPP9

9.46e-0428372CID000122318
DrugValboroPro

DPP4 DPP9

9.46e-0428372CID006918572
Drugprotocatechuic acid

DPP4 DPP9 ALOX15B

9.50e-04119373CID000000072
Diseaseseminoma (is_marker_for)

JUP INSR

3.67e-0422382DOID:4440 (is_marker_for)
DiseaseDrug habituation

PCDH15 CHD1L INSR

4.40e-04115383C0013170
DiseaseSubstance-Related Disorders

PCDH15 CHD1L INSR

4.40e-04115383C0236969
DiseaseDrug abuse

PCDH15 CHD1L INSR

4.40e-04115383C0013146
DiseaseDrug Use Disorders

PCDH15 CHD1L INSR

4.40e-04115383C0013222
DiseaseDrug Dependence

PCDH15 CHD1L INSR

4.40e-04115383C1510472
DiseaseSubstance Dependence

PCDH15 CHD1L INSR

4.40e-04115383C0038580
DiseaseSubstance Use Disorders

PCDH15 CHD1L INSR

4.40e-04115383C0038586
DiseaseOrganic Mental Disorders, Substance-Induced

PCDH15 CHD1L INSR

4.40e-04115383C0029231
DiseasePrescription Drug Abuse

PCDH15 CHD1L INSR

4.40e-04115383C4316881
DiseaseSubstance abuse problem

PCDH15 CHD1L INSR

4.52e-04116383C0740858
Diseasediabetes mellitus (implicated_via_orthology)

LRP1 INSR

5.15e-0426382DOID:9351 (implicated_via_orthology)
Diseasepresubiculum volume

DPP4 WNK2

7.33e-0431382EFO_0009400
Diseasehippocampus molecular layer volume

DPP4 WNK2

9.35e-0435382EFO_0009397
Diseasedentate gyrus volume measurement

DPP4 ALOX15B

1.16e-0339382EFO_0010083

Protein segments in the cluster

PeptideGeneStartEntry
MYDDSYVPGFEDSEA

CACNB3

1

P54284
ADSYYYEDGGMKPRV

CCDC50

141

Q8IVM0
DYGDGYVIPNYDDMD

AEBP1

301

Q8IUX7
MDPEETSVYLDYYYA

GPR15

1

P49685
NPEEMTSRDYYFDSY

PRMT8

66

Q9NR22
YTIEGEEERVSYYME

CELSR1

271

Q9NYQ6
YVYVFDGYRMEECAP

ANO2

656

Q9NQ90
RGDRYMLVTYDEPPY

INTS6L

46

Q5JSJ4
QYPYDRYGTMDSGTR

IRX4

131

P78413
IEDSGYKEYYSIPVM

ANKAR

416

Q7Z5J8
RDSQGELMVYPYYGE

NOTCH2

1581

Q04721
YYIEYMESTRDDSPL

JMJD6

116

Q6NYC1
PYDVQYSDIDYMDGK

MGAM2

361

Q2M2H8
MSYPADDYESEAAYD

EIF3L

1

Q9Y262
MEIRGVDLDAPYYNY

LRP1

1591

Q07954
SYPYSEDARQGEQYM

INPP5A

326

Q14642
DESEMLGSTPYTYYG

LHX5

266

Q9H2C1
YYDSVYTERYMGLPT

DPP4

661

P27487
YHLERYPDSYESMSE

TUBGCP6

1426

Q96RT7
GDFGMTRDIYETDYY

INSR

1176

P06213
LFMGDYVDRGYYSVE

PPP2CB

81

P62714
LFMGDYVDRGYYSVE

PPP2CA

81

P67775
EPYGDDMDATYRPMY

JUP

691

P14923
YMYAPEDAEVLRPYS

SBF1

1571

O95248
EISYDVYVYTDMRPG

PCDH15

511

Q96QU1
AYDTGYTERYMDVPE

DPP9

761

Q86TI2
DRGDGMYKVEYTPYE

FLNA

1311

P21333
DYMDYRGYSYERVDG

CHD1L

381

Q86WJ1
EYEGIPMAEEYDYVH

EFS

371

O43281
YEDMIGEEVPSDQYY

CTNND1

321

O60716
RPYAYMYNSDKDTVE

KIF1A

1601

Q12756
EDIPGYYYRDDGMQI

ALOX15B

466

O15296
SEEAYIDPIAMEYYN

LAT2

106

Q9GZY6
IYYSAVDPIKDMYSG

HEPH

881

Q9BQS7
VIVMEYASRGDLYDY

NUAK2

126

Q9H093
VPYASENAIYEMGYT

LINC00643

21

Q86TS7
PEMYEEHYDESVDVY

WNK2

366

Q9Y3S1
DEGLYTIRVRMGEYY

MYOM1

476

P52179
SYYQPDMEYSEIVGL

PPP1R9A

431

Q9ULJ8