Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncargo receptor activity

COLEC12 VLDLR ASGR1 LRP1

7.08e-0585524GO:0038024
GeneOntologyMolecularFunctionproteoglycan binding

COL2A1 LRP1 GPNMB

3.18e-0451523GO:0043394
GeneOntologyMolecularFunctionzinc ion binding

PHEX UBR5 DTX4 PRIM1 OTUD7A NOS1 FBXO30 CA1 OTUD7B

4.40e-04891529GO:0008270
GeneOntologyMolecularFunctionL-glutamate transmembrane transporter activity

GRIK1 SLC17A6

6.83e-0415522GO:0005313
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

VLDLR LRP1

7.80e-0416522GO:0005041
GeneOntologyMolecularFunctionglutamate-gated receptor activity

GRIA4 GRIK1

8.82e-0417522GO:0004970
GeneOntologyMolecularFunctionapolipoprotein binding

VLDLR LRP1

1.23e-0320522GO:0034185
GeneOntologyMolecularFunctionacidic amino acid transmembrane transporter activity

GRIK1 SLC17A6

1.23e-0320522GO:0015172
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

VLDLR LRP1

1.35e-0321522GO:0030228
GeneOntologyMolecularFunctionsyntaxin-1 binding

STXBP5 UNC13C

1.77e-0324522GO:0017075
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

GRIA4 GRIK1

1.77e-0324522GO:0099507
GeneOntologyMolecularFunctionscaffold protein binding

GRIK1 NOS1 NCK2

1.83e-0393523GO:0097110
GeneOntologyMolecularFunctionmodification-dependent protein binding

OTUD7A CDYL OTUD7B SPIN3

2.02e-03206524GO:0140030
GeneOntologyMolecularFunctionK63-linked polyubiquitin modification-dependent protein binding

OTUD7A OTUD7B

2.08e-0326522GO:0070530
GeneOntologyMolecularFunctionglutamate receptor activity

GRIA4 GRIK1

2.24e-0327522GO:0008066
GeneOntologyMolecularFunctionscavenger receptor activity

COLEC12 LRP1

2.24e-0327522GO:0005044
GeneOntologyMolecularFunctionamyloid-beta binding

CLSTN3 LRP1 GRIA4

2.39e-03102523GO:0001540
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

GRIA4 GRIK1 SLC17A6

2.59e-03105523GO:0015171
GeneOntologyMolecularFunctioncalmodulin binding

MYO1E IQCB1 UNC13C NOS1

3.01e-03230524GO:0005516
GeneOntologyMolecularFunctiontransition metal ion binding

PHEX UBR5 DTX4 PRIM1 OTUD7A NOS1 FBXO30 CA1 OTUD7B

3.30e-031189529GO:0046914
GeneOntologyMolecularFunctionlipoprotein particle binding

COLEC12 VLDLR

3.75e-0335522GO:0071813
GeneOntologyMolecularFunctionprotein-lipid complex binding

COLEC12 VLDLR

3.75e-0335522GO:0071814
GeneOntologyMolecularFunctionSNARE binding

STXBP5 UNC13C GRIK1

5.35e-03136523GO:0000149
GeneOntologyBiologicalProcesssynaptic transmission, glutamatergic

CLSTN3 GRIA4 UNC13C GRIK1 SLC17A6

2.23e-05132535GO:0035249
GeneOntologyBiologicalProcessdisaccharide catabolic process

TREH LCT

3.87e-054532GO:0046352
GeneOntologyCellularComponentpresynaptic membrane

STXBP5 ITSN1 GRIA4 UNC13C GRIK1 CNTN6

6.98e-05277536GO:0042734
GeneOntologyCellularComponentkainate selective glutamate receptor complex

GRIA4 GRIK1

9.40e-056532GO:0032983
GeneOntologyCellularComponentsynaptic membrane

CLSTN3 STXBP5 ITSN1 LRP1 GRIA4 UNC13C GRIK1 CNTN6

1.02e-04583538GO:0097060
GeneOntologyCellularComponentcalyx of Held

ITSN1 UNC13C NOS1

1.04e-0436533GO:0044305
GeneOntologyCellularComponentaxon terminus

ITSN1 GRIA4 UNC13C GRIK1 NOS1

1.89e-04210535GO:0043679
GeneOntologyCellularComponentneuron projection terminus

ITSN1 GRIA4 UNC13C GRIK1 NOS1

3.06e-04233535GO:0044306
GeneOntologyCellularComponentneuron to neuron synapse

CLSTN3 STXBP5 LRP1 GRIA4 GRIK1 NOS1 NCK2

3.35e-04523537GO:0098984
GeneOntologyCellularComponentaxon

ITSN1 LRP1 GRIA4 UNC13C GRIK1 NOS1 CNTN6 EPHA5 SLC17A6

3.65e-04891539GO:0030424
GeneOntologyCellularComponentreceptor complex

VLDLR FLT4 STXBP5 LRP1 GRIA4 GRIK1 EPHA5

6.29e-04581537GO:0043235
GeneOntologyCellularComponentpostsynaptic density membrane

CLSTN3 LRP1 GRIA4 GRIK1

6.73e-04157534GO:0098839
GeneOntologyCellularComponentdistal axon

ITSN1 LRP1 GRIA4 UNC13C GRIK1 NOS1

7.88e-04435536GO:0150034
GeneOntologyCellularComponentpostsynaptic density

CLSTN3 LRP1 GRIA4 GRIK1 NOS1 NCK2

9.50e-04451536GO:0014069
GeneOntologyCellularComponentclathrin-coated pit

VLDLR ITSN1 LRP1

1.10e-0380533GO:0005905
GeneOntologyCellularComponentasymmetric synapse

CLSTN3 LRP1 GRIA4 GRIK1 NOS1 NCK2

1.27e-03477536GO:0032279
GeneOntologyCellularComponentside of membrane

BTN3A3 TREH ASGR1 LRP1 LCT STAC CNTN6 EPHA5

1.52e-03875538GO:0098552
GeneOntologyCellularComponentpresynapse

STXBP5 ITSN1 GRIA4 UNC13C GRIK1 NOS1 CNTN6 SLC17A6

1.65e-03886538GO:0098793
GeneOntologyCellularComponentpostsynaptic specialization

CLSTN3 LRP1 GRIA4 GRIK1 NOS1 NCK2

1.66e-03503536GO:0099572
GeneOntologyCellularComponentpostsynaptic specialization membrane

CLSTN3 LRP1 GRIA4 GRIK1

1.68e-03201534GO:0099634
GeneOntologyCellularComponentterminal bouton

GRIA4 UNC13C GRIK1

1.86e-0396533GO:0043195
GeneOntologyCellularComponentsodium channel complex

GRIA4 GRIK1

2.45e-0329532GO:0034706
GeneOntologyCellularComponentexcitatory synapse

UNC13C CNTN6 SLC17A6

2.54e-03107533GO:0060076
GeneOntologyCellularComponentendocytic vesicle

COLEC12 MYO1E ITSN1 LRP1 GRIA4

2.84e-03384535GO:0030139
GeneOntologyCellularComponentglutamatergic synapse

VLDLR CLSTN3 ITSN1 LRP1 GRIA4 GRIK1 NOS1

4.37e-03817537GO:0098978
MousePhenoabnormal CNS synaptic transmission

COLEC12 VLDLR CLSTN3 CCDC9B STXBP5 SMCHD1 ITSN1 OTUD7A GRIA4 UNC13C GRIK1 NOS1 FBXO30 CA1 EPHA5 SLC17A6

3.02e-089854516MP:0002206
MousePhenoabnormal synaptic transmission

COLEC12 VLDLR CLSTN3 CCDC9B STXBP5 SMCHD1 ITSN1 OTUD7A GRIA4 UNC13C GRIK1 NOS1 FBXO30 CA1 EPHA5 SLC17A6

9.61e-0810704516MP:0003635
MousePhenoabnormal synaptic physiology

COLEC12 VLDLR CLSTN3 CCDC9B STXBP5 SMCHD1 ITSN1 OTUD7A GRIA4 UNC13C GRIK1 NOS1 FBXO30 CA1 EPHA5 SLC17A6

1.04e-0710764516MP:0021009
DomainCezanne-2

OTUD7A OTUD7B

7.90e-062532IPR033477
DomainSH3_1

NPHP1 MYO1E ITSN1 STAC NCK2

1.00e-04164535PF00018
DomainZnf_A20

OTUD7A OTUD7B

1.64e-047532IPR002653
DomainZF_A20

OTUD7A OTUD7B

1.64e-047532PS51036
Domainzf-A20

OTUD7A OTUD7B

1.64e-047532PF01754
DomainZnF_A20

OTUD7A OTUD7B

1.64e-047532SM00259
DomainSH3

NPHP1 MYO1E ITSN1 STAC NCK2

3.61e-04216535SM00326
DomainSH3

NPHP1 MYO1E ITSN1 STAC NCK2

3.61e-04216535PS50002
DomainSH3_domain

NPHP1 MYO1E ITSN1 STAC NCK2

3.93e-04220535IPR001452
DomainOTU

OTUD7A OTUD7B

6.04e-0413532PF02338
DomainATPase_dyneun-rel_AAA

MDN1 DYNC2H1

7.03e-0414532IPR011704
DomainLdl_recept_b

VLDLR LRP1

7.03e-0414532PF00058
DomainLDLRB

VLDLR LRP1

7.03e-0414532PS51120
DomainAAA_5

MDN1 DYNC2H1

7.03e-0414532PF07728
DomainOTU

OTUD7A OTUD7B

8.10e-0415532PS50802
DomainOTU_dom

OTUD7A OTUD7B

8.10e-0415532IPR003323
DomainLY

VLDLR LRP1

8.10e-0415532SM00135
DomainLDLR_classB_rpt

VLDLR LRP1

8.10e-0415532IPR000033
DomainIontro_rcpt

GRIA4 GRIK1

1.17e-0318532IPR001320
DomainLig_chan-Glu_bd

GRIA4 GRIK1

1.17e-0318532PF10613
DomainIono_rcpt_met

GRIA4 GRIK1

1.17e-0318532IPR001508
DomainGlu/Gly-bd

GRIA4 GRIK1

1.17e-0318532IPR019594
DomainLig_chan-Glu_bd

GRIA4 GRIK1

1.17e-0318532SM00918
DomainLig_chan

GRIA4 GRIK1

1.17e-0318532PF00060
DomainPBPe

GRIA4 GRIK1

1.17e-0318532SM00079
DomainANF_lig-bd_rcpt

GRIA4 GRIK1

4.94e-0337532IPR001828
DomainANF_receptor

GRIA4 GRIK1

4.94e-0337532PF01094
DomainPeripla_BP_I

GRIA4 GRIK1

5.47e-0339532IPR028082
Domain-

VLDLR LRP1

5.47e-03395322.120.10.30
DomainLDLR_class-A_CS

VLDLR LRP1

5.75e-0340532IPR023415
DomainEGF-like_CS

VLDLR LAMB4 LRP1 EPHA5

6.38e-03261534IPR013032
DomainC-type_lectin_CS

COLEC12 ASGR1

6.62e-0343532IPR018378
DomainEGF_2

VLDLR LAMB4 LRP1 EPHA5

6.73e-03265534PS01186
DomainLdl_recept_a

VLDLR LRP1

7.23e-0345532PF00057
Domain-

VLDLR LRP1

7.55e-03465324.10.400.10
Domain6-blade_b-propeller_TolB-like

VLDLR LRP1

7.55e-0346532IPR011042
DomainLDLRA_1

VLDLR LRP1

8.20e-0348532PS01209
DomainLDLRA_2

VLDLR LRP1

8.53e-0349532PS50068
DomainLDrepeatLR_classA_rpt

VLDLR LRP1

8.53e-0349532IPR002172
DomainLDLa

VLDLR LRP1

8.53e-0349532SM00192
DomainGrowth_fac_rcpt_

VLDLR LRP1 EPHA5

9.87e-03156533IPR009030
Pubmed

Estimation of Current and Future Physiological States in Insular Cortex.

NOS1 SLC17A6

2.28e-06253231955944
Pubmed

Co-occurrence of Spondyloepiphyseal Dysplasia and X-Linked Hypophosphatemia in a Three-Generation Chinese Family.

COL2A1 PHEX

2.28e-06253237278761
Pubmed

Gene mutation analysis in Iranian children with nephronophthisis: a two-center study.

NPHP1 IQCB1

2.28e-06253225851290
Pubmed

Clearance of coagulation factor VIII in very low-density lipoprotein receptor knockout mice.

VLDLR LRP1

2.28e-06253215327526
Pubmed

The binding sites for the very low density lipoprotein receptor and low-density lipoprotein receptor-related protein are shared within coagulation factor VIII.

VLDLR LRP1

6.83e-06353218277139
Pubmed

The gene mutated in juvenile nephronophthisis type 4 encodes a novel protein that interacts with nephrocystin.

NPHP1 IQCB1

6.83e-06353212244321
Pubmed

Cloning and functional expression of a cDNA encoding the mouse beta 2 subunit of the kainate-selective glutamate receptor channel.

GRIA4 GRIK1

6.83e-0635321379666
Pubmed

SENIOR-LØKEN SYNDROME: A Case Series and Review of the Renoretinal Phenotype and Advances of Molecular Diagnosis.

NPHP1 IQCB1

6.83e-06353233512896
Pubmed

The hepatic uptake of VLDL in lrp-ldlr-/-vldlr-/- mice is regulated by LPL activity and involves proteoglycans and SR-BI.

VLDLR LRP1

6.83e-06353218367731
Pubmed

The relationship among apolipoprotein(a) polymorphisms, the low-density lipoprotein receptor-related protein, and the very low density lipoprotein receptor genes, and plasma lipoprotein(A) concentration in the Czech population.

VLDLR LRP1

6.83e-06353211931574
Pubmed

Supramammillary glutamate neurons are a key node of the arousal system.

NOS1 SLC17A6

6.83e-06353229123082
Pubmed

Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.

ITSN1 OTUD7A GRIA4 NOS1 NCK2

1.28e-0519753536604605
Pubmed

NMDA Receptors in the Lateral Preoptic Hypothalamus Are Essential for Sustaining NREM and REM Sleep.

NOS1 SLC17A6

1.36e-05453235649726
Pubmed

A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy.

NOS1 SLC17A6

1.36e-05453232066723
Pubmed

Hindbrain Double-Negative Feedback Mediates Palatability-Guided Food and Water Consumption.

NOS1 SLC17A6

1.36e-05453232841600
Pubmed

Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomes.

NPHP1 IQCB1

1.36e-05453215661758
Pubmed

Hierarchical neural architecture underlying thirst regulation.

NOS1 SLC17A6

1.36e-05453229489747
Pubmed

Sensory regulation of absence seizures in a mouse model of Gnb1 encephalopathy.

GRIA4 SLC17A6

1.36e-05453236405774
Pubmed

Distinct immunohistochemically defined areas in the medial amygdala in the developing and adult mouse.

NOS1 SLC17A6

1.36e-05453218331873
Pubmed

The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor.

VLDLR LRP1

1.36e-05453215863833
Pubmed

Phenotyping of nNOS neurons in the postnatal and adult female mouse hypothalamus.

NOS1 SLC17A6

1.36e-05453228577305
Pubmed

The pheromone darcin drives a circuit for innate and reinforced behaviours.

NOS1 SLC17A6

1.36e-05453231996852
Pubmed

LDL receptor cooperates with LDL receptor-related protein in regulating plasma levels of coagulation factor VIII in vivo.

VLDLR LRP1

1.36e-05453215840700
Pubmed

Cloning of a complementary deoxyribonucleic acid encoding the murine homolog of the very low density lipoprotein/apolipoprotein-E receptor: expression pattern and assignment of the gene to mouse chromosome 19.

VLDLR LRP1

2.27e-0555328013374
Pubmed

RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.

GRIA4 GRIK1

2.27e-0555321717158
Pubmed

Critical Role of SREBP-1c Large-VLDL Pathway in Environment-Induced Hypertriglyceridemia of Apo AV Deficiency.

VLDLR LRP1

2.27e-05553230700132
Pubmed

GABA and glutamate neurons in the VTA regulate sleep and wakefulness.

NOS1 SLC17A6

2.27e-05553230559475
Pubmed

Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia.

VLDLR LRP1

2.27e-05553212746448
Pubmed

Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo.

VLDLR LRP1

2.27e-05553218992221
Pubmed

Fiber type-specific nitric oxide protects oxidative myofibers against cachectic stimuli.

FBXO32 NOS1

2.27e-05553218461174
Pubmed

Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance.

VLDLR LRP1

2.27e-05553223959870
Pubmed

Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals.

NPHP1 NCK2

2.27e-05553220856870
Pubmed

Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509.

VLDLR LRP1

2.27e-05553218685438
Pubmed

Warm-Sensitive Neurons that Control Body Temperature.

NOS1 SLC17A6

3.40e-05653227616062
Pubmed

Apolipoprotein CI causes hypertriglyceridemia independent of the very-low-density lipoprotein receptor and apolipoprotein CIII in mice.

VLDLR LRP1

3.40e-05653216478678
Pubmed

Ciliopathy-associated protein CEP290 modifies the severity of retinal degeneration due to loss of RPGR.

NPHP1 IQCB1

3.40e-05653226936822
Pubmed

Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus.

VLDLR ITSN1

3.40e-05653228484035
Pubmed

The Forebrain Thirst Circuit Drives Drinking through Negative Reinforcement.

NOS1 SLC17A6

3.40e-05653229268095
Pubmed

Sensory representation and detection mechanisms of gut osmolality change.

NOS1 SLC17A6

3.40e-05653235082448
Pubmed

Mouse models of ocular diseases.

COL2A1 VLDLR GPNMB

4.23e-054453316332269
Pubmed

Glutamate receptors in cortical plasticity: molecular and cellular biology.

GRIA4 GRIK1

4.76e-0575329016303
Pubmed

Glutamate receptors: brain function and signal transduction.

GRIA4 GRIK1

4.76e-0575329651535
Pubmed

The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.

VLDLR LRP1

4.76e-05753212169628
Pubmed

Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains.

OTUD7A OTUD7B

4.76e-05753218281465
Pubmed

An inter-organ neural circuit for appetite suppression.

NOS1 SLC17A6

4.76e-05753235662413
Pubmed

Specific connections of the interpeduncular subnuclei reveal distinct components of the habenulopeduncular pathway.

NOS1 SLC17A6

4.76e-05753228387937
Pubmed

Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate.

GRIA4 GRIK1

4.76e-0575321310861
Pubmed

Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes.

VLDLR LRP1

4.76e-05753223760271
Pubmed

Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality.

NOS1 SLC17A6

4.76e-05753234585668
Pubmed

Transmembrane topology of the glutamate receptor subunit GluR6.

GRIA4 GRIK1

6.34e-0585328163463
Pubmed

Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.

VLDLR LRP1

6.34e-05853210380922
Pubmed

HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes.

LRP1 NOS1

6.34e-05853217360663
Pubmed

A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.

OTUD7A CNTN6

6.34e-05853223650146
Pubmed

scRNA-Seq Reveals New Enteric Nervous System Roles for GDNF, NRTN, and TBX3.

NOS1 SLC17A6

6.34e-05853233444816
Pubmed

HIV-1 protein Tat produces biphasic changes in NMDA-evoked increases in intracellular Ca2+ concentration via activation of Src kinase and nitric oxide signaling pathways.

LRP1 NOS1

8.15e-05953224666322
Pubmed

Targeted inactivation of the mouse alpha 2-macroglobulin gene.

VLDLR LRP1

8.15e-0595327544347
Pubmed

EphrinB1 modulates glutamatergic inputs into POMC-expressing progenitors and controls glucose homeostasis.

EPHA5 SLC17A6

8.15e-05953233253166
Pubmed

Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus.

NPHP1 IQCB1

8.15e-05953229959317
Pubmed

Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data.

GRIA4 GRIK1

8.15e-05953234100982
Pubmed

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.

VLDLR LRP1

8.15e-05953220005821
Pubmed

Expression of glutamate receptor subunit genes during development of the mouse retina.

GRIA4 GRIK1

8.15e-0595329051806
Pubmed

Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome.

NPHP1 ITSN1 NCK2

8.75e-055653322745667
Pubmed

Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.

GRIA4 GRIK1 NOS1 CNTN6 SLC17A6

9.44e-0530053519086053
Pubmed

A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.

DYNC2H1 PRIM1 IQCB1 EPHA5 OTUD7B

9.74e-0530253530561431
Pubmed

New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis.

PHEX ASGR1

1.02e-041053222527485
Pubmed

Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease.

COL2A1 CDYL

1.24e-041153215101818
Pubmed

The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs.

GRIA4 GRIK1

1.49e-041253211891216
Pubmed

Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice.

COL2A1 LRP1

1.76e-041353216207730
Pubmed

Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.

GRIA4 GRIK1

1.76e-041353220859245
Pubmed

Blimp1 regulates the transition of neonatal to adult intestinal epithelium.

TREH LCT

1.76e-041353221878906
Pubmed

Stage-specific association of apolipoprotein A-I and E in developing mouse retina.

VLDLR LRP1

2.05e-041453217389516
Pubmed

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.

VLDLR LRP1

2.05e-041453215082773
Pubmed

Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation.

VLDLR FLT4

2.05e-041453222665518
Pubmed

Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development.

NPHP1 SMCHD1 GRIA4 FBXO30

2.31e-0419653419334288
Pubmed

Positive autofeedback regulation of Ptf1a transcription generates the levels of PTF1A required to generate itch circuit neurons.

NOS1 SLC17A6

2.36e-041553232241803
Pubmed

Generation and characterization of Tmeff2 mutant mice.

NOS1 SLC17A6

2.36e-041553222828515
Pubmed

Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays.

TEAD2 FLT4 STAC EPHA5

2.64e-0420353419953087
Pubmed

Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.

CLSTN3 GRIA4 GRIK1 PADI2 NOS1

2.70e-0437653524154525
Pubmed

A genomic atlas of mouse hypothalamic development.

TBX19 NOS1 EPHA5 SLC17A6

2.74e-0420553420436479
Pubmed

Regional cytoarchitecture of the adult and developing mouse enteric nervous system.

NOS1 SLC17A6

3.05e-041753236070775
Pubmed

ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family.

ADAMTS6 GRIK1

3.05e-041753210464288
Pubmed

Adult mouse cortical cell taxonomy revealed by single cell transcriptomics.

NOS1 SLC17A6

3.43e-041853226727548
Pubmed

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.

VLDLR LRP1

3.43e-041853210827173
Pubmed

Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy.

NPHP1 IQCB1

3.43e-041853221068128
Pubmed

Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders.

DYNC2H1 ITSN1

3.43e-041853227984743
Pubmed

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.

OTUD7A OTUD7B

3.83e-041953223827681
Pubmed

Enhancer viruses for combinatorial cell-subclass-specific labeling.

NOS1 SLC17A6

4.25e-042053233789083
Pubmed

MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.

VLDLR LRP1

4.70e-042153221337463
Pubmed

Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology.

COL2A1 PHEX

4.70e-042153226234751
Pubmed

Stat3 loss in mesenchymal progenitors causes Job syndrome-like skeletal defects by reducing Wnt/β-catenin signaling.

COL2A1 PHEX

4.70e-042153234172578
Pubmed

Nephronophthisis-Related Ciliopathies

NPHP1 IQCB1

4.70e-042153227336129
Pubmed

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.

ADAMTS6 DYNC2H1 LRP1

4.87e-0410053325807483
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

VLDLR FLT4 LRP1

5.01e-0410153323382219
Pubmed

Zbtb20 Regulates Developmental Neurogenesis in the Olfactory Bulb and Gliogenesis After Adult Brain Injury.

NOS1 SLC17A6

5.16e-042253229748916
Pubmed

Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.

GRIA4 GRIK1

5.65e-04235328464923
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

TBX19 TEAD2 GRIA4 GRIK1 PADI2 CNTN6

6.02e-0468653629987050
Pubmed

Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling.

PHEX VLDLR MAMDC2

6.09e-0410853331202927
Pubmed

Glutamate can act as a signaling molecule in mouse preimplantation embryos†.

GRIA4 GRIK1

6.16e-042453235746896
Pubmed

Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.

GRIA4 GRIK1

6.16e-042453222534482
Pubmed

FOXC1 and FOXC2 regulate growth plate chondrocyte maturation towards hypertrophy in the embryonic mouse limb skeleton.

COL2A1 PHEX

6.16e-042453239012257
Cytoband3p22.3

OSBPL10 STAC

5.95e-04315323p22.3
GeneFamilyLow density lipoprotein receptors

VLDLR LRP1

3.31e-0413382634
GeneFamilyOTU domain containing

OTUD7A OTUD7B

5.73e-0417382669
GeneFamilyCyclins|F-boxes other

FBXO32 FBXO30

3.03e-0339382560
ToppCellCOVID-19-Heart-CM_5_(RYR2-)|Heart / Disease (COVID-19 only), tissue and cell type

NPHP1 UNC13C FBXO32 PADI2 NOS1

1.14e-06155535d7e26696fd9c0a759524f331243db43059b33ed9
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|356C / Donor, Lineage, Cell class and subclass (all cells)

ASGR1 PRIM1 FAM13B STAC SPIN3

1.29e-0615953524f87c666eff10c1844c900ffd7ad49fa9f80481
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COLEC12 LRP1 OSBPL10 GPNMB STAC

1.91e-06172535c8ea80042faf923b08ff03d73100533d521d73ef
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COLEC12 ADAMTS6 GRIK1 SLC12A7 CNTN6

2.45e-06181535062f00736eed96e4f4327615d093558dd7d82b20
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COLEC12 ADAMTS6 GRIK1 SLC12A7 CNTN6

2.51e-06182535d3a037268f026eb2f84428b1821022503cef7756
ToppCelldroplet-Lung-nan-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COLEC12 MAMDC2 DTX4 OTUD7A GRIA4

2.58e-06183535a253ad65673fce6cb453e709cb235ce7cbfa18b7
ToppCelldroplet-Lung-nan-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COLEC12 MAMDC2 DTX4 OTUD7A GRIA4

2.58e-06183535ddc45fb591ba0ce3fa05c08051d58286a89ef835
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COLEC12 ADAMTS6 GRIK1 SLC12A7 CNTN6

2.72e-061855350b5a0df58ae2ad8261f40f152775747af4f3937a
ToppCell10x5'-GI_large-bowel-Myeloid_Monocytic|GI_large-bowel / Manually curated celltypes from each tissue

COLEC12 ASGR1 MAMDC2 LRP1 GPNMB

2.95e-06188535d0045fdda757d191dabc7853f6a6e99c0e97d93d
ToppCell10x5'-GI_large-bowel-Myeloid_Monocytic-Classical_monocytes|GI_large-bowel / Manually curated celltypes from each tissue

COLEC12 ASGR1 MAMDC2 LRP1 GPNMB

2.95e-061885350bcf04aa47738f43c1a87dae5dc487738ee86f8c
ToppCellhuman_hepatoblastoma-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

MYO1E UBR5 ITSN1 OSBPL10 CDYL

2.95e-06188535b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIA4 UNC13C GRIK1 NOS1 CA1

3.02e-06189535222e67d3fd106c43b0cae6538dddeaa7be1f759f
ToppCellCOPD-Myeloid-Macrophage_Alveolar|COPD / Disease state, Lineage and Cell class

COLEC12 ASGR1 LRP1 GPNMB STAC

3.10e-06190535006e31606d637033bc81333816ee332773d36b08
ToppCellCOPD-Myeloid-Macrophage_Alveolar|Myeloid / Disease state, Lineage and Cell class

COLEC12 ASGR1 LRP1 GPNMB STAC

3.10e-061905359fc763d65470ba8858b973689c4d4358faab7dd3
ToppCellPND14-Mesenchymal-Mesenchymal_structural|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PHEX COLEC12 VLDLR MAMDC2 LRP1

3.26e-0619253525492568f9cbe097b7bb1db50d8b817c80ea87d7
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PHEX COLEC12 VLDLR MAMDC2 LRP1

3.26e-06192535de9c1536d5aee86f9c62acbc54ca8fa581c00f17
ToppCelldroplet-Kidney-nan-18m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COLEC12 LRP1 GRIA4 GPNMB CNTN6

3.26e-0619253584149a5c6c3b3c9b86aed77cf8e72d99ef099fab
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

COLEC12 MAMDC2 ITSN1 LRP1 GPNMB

3.43e-0619453545708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PHEX COLEC12 VLDLR MAMDC2 LRP1

3.52e-061955353a0cad69cfc150a27a0666f612f5294c817197d7
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PHEX COLEC12 VLDLR MAMDC2 LRP1

3.52e-061955352b8ee7990267bb52b7e6ae03f509ffebf8908122
ToppCellMonocytes-Phagocytic_CD16+_macrophages|World / Immune cells in Kidney/Urine in Lupus Nephritis

MYO1E ASGR1 ITSN1 LRP1 GPNMB

3.79e-0619853509009cc966bf1503c3b15dfa079a6c5f6ad1f507
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

COL2A1 PHEX COLEC12 DYNC2H1 UNC13C

3.79e-061985350c4d2c68a42f8a9e964e2dd28092fe75f5216834
ToppCellBronchus_Control_(B.)-Immune-TX-MoAM-2|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

COLEC12 MAMDC2 ITSN1 LRP1 GPNMB

3.89e-06199535fb63885273d906a85fef178d859d20a311eb8a72
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PHEX COLEC12 CLSTN3 ITSN1 LRP1

3.89e-061995358b86c69aaf60feff53aa782559cfece7342a23de
ToppCellMild-Myeloid-Macrophages-FABP4+|Mild / Condition, Lineage, Cell class and cell subclass

COLEC12 DTX4 LRP1 GPNMB STAC

3.89e-061995357bfd6ca4b0f2683715c24dfd7cf40418b5b8ddf2
ToppCellBAL-Severe-cDC_0|Severe / Compartment, Disease Groups and Clusters

COLEC12 ASGR1 LRP1 GPNMB STAC

3.89e-06199535d39be8b173156bf87baddd3caed4b35597c53ea1
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2|Neuronal / cells hierarchy compared to all cells using T-Statistic

COLEC12 ADAMTS6 GRIK1 SLC12A7 CNTN6

3.98e-06200535501a3b93624df463458a35d3e6648d4ccc941724
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2-L1-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

COLEC12 ADAMTS6 GRIK1 SLC12A7 CNTN6

3.98e-06200535d1f36a8232411933b1494168ec912fd0e5246428
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

PHEX COLEC12 DYNC2H1 ITSN1 LRP1

3.98e-06200535a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Th_Sst|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MYO1E ADAMTS6 GRIK1 GPNMB

1.54e-051265343a14d4eb8803827946c36faeeb7ae2913418d421
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Gabrg1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MYO1E GRIK1 PADI2 NOS1

2.34e-051405342c44e8cc5190226049be7ebc465d685393e701c4
ToppCellCOVID-19-Heart-CM_5_(RYR2-)|COVID-19 / Disease (COVID-19 only), tissue and cell type

UNC13C FBXO32 PADI2 NOS1

2.61e-05144534f92e03dd784e31a9e5dbd4f4c3a6517ea19210cf
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-early_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC9B UNC13C EPHA5 SLC17A6

2.61e-051445341d05aa08603cba28c0c6511767e434c1f592a3aa
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-early_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC9B UNC13C EPHA5 SLC17A6

2.61e-05144534d3f6f5da56794367ee3776bfd3a9dcf893efe0f0
ToppCellfacs-Marrow-Granulocytes-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPHP1 ADAMTS6 MAMDC2 ITSN1

3.48e-05155534cd2f3ad4f131588325a667b6724e530d821fbe30
ToppCellfacs-Marrow-Granulocytes-3m-Hematologic-MPP_Fraction_B|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPHP1 ADAMTS6 MAMDC2 ITSN1

3.48e-051555349b26ade19488511c72b64335011d2dcd81e8f167
ToppCellfacs-Marrow-Granulocytes-3m-Hematologic-hematopoietic_stem_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPHP1 ADAMTS6 MAMDC2 ITSN1

3.48e-051555344246709e27703b94529369abbed5763e4002e79d
ToppCellfacs-Lung-EPCAM-24m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT4 DYNC2H1 SMCHD1 OSBPL10

4.65e-05167534961e722442d786ab15d1e490941d2be265a9057a
ToppCellfacs-Lung-EPCAM-24m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT4 DYNC2H1 SMCHD1 OSBPL10

4.65e-051675343760efc35d4e7e9c2da1a20f9795ddea397e2206
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL2A1 DTX4 STAC EPHA5

4.76e-0516853495dc690c1987b05685d36e6bb20eb79308696e30
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COLEC12 MAMDC2 OTUD7A CNTN6

4.76e-05168534d2b91f2adc95dcfa623f8d7ca2df1c6f884da988
ToppCell10x5'-GI_small-bowel-Myeloid_Mac-Macrophage|GI_small-bowel / Manually curated celltypes from each tissue

COLEC12 LRP1 GPNMB STAC

4.76e-05168534d5b746d6083c2c8155a0ea345ea368bf6617d5ca
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COLEC12 VLDLR MAMDC2 EPHA5

4.87e-05169534031465190cd3623a25ef2b868daab8d932c8ff08
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TBX19 COLEC12 VLDLR PRIM1

4.99e-05170534e20568c8f3f17d94de78229617eb2f7e4c5af2bc
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COLEC12 VLDLR MAMDC2 EPHA5

5.10e-0517153415cb4670ff4234ac46aea8a5911138d6913c4482
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COLEC12 FLT4 ASGR1 GRIK1

5.34e-051735347dc988fc0ba29990567bf1bcdeb3faeeee507eb1
ToppCellP15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PHEX COLEC12 MAMDC2 LRP1

5.46e-051745343c47d069bd836599a8d40eae485c23d4d3487517
ToppCell10x5'-bone_marrow-Myeloid_Mac-Intestinal_macrophages|bone_marrow / Manually curated celltypes from each tissue

COLEC12 MAMDC2 LRP1 GPNMB

5.46e-051745340746344d62aa7ab77c378e9d5a9f9238e741a76b
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COLEC12 ADAMTS6 GRIK1 SLC12A7

5.83e-0517753484116796ca4c7007508c0f1a68a1135c7b922278
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COLEC12 ADAMTS6 GRIK1 SLC12A7

5.96e-051785342a36475c260088f69f3b8c282d910e5eaa5c5c2d
ToppCell21-Trachea-Epithelial-Submucosal_gland|Trachea / Age, Tissue, Lineage and Cell class

TEAD2 TREH DTX4 PADI2

5.96e-051785343e406e38eea0d38dc25edecf703c4c89ec6a28e0
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-4|TCGA-Breast / Sample_Type by Project: Shred V9

TBX19 PADI2 STAC NCK2

5.96e-0517853444b5ba4e8788d3973749a1717e427647ac4c8579
ToppCell(2)_MNPs-(2)_Mono_macro|(2)_MNPs / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

ASGR1 LRP1 GPNMB

6.11e-0564533494f500ccceeedf45b4ded919b237a7fb75827c4
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL2A1 GRIA4 PADI2 CNTN6

6.23e-05180534c72f15763ba707189e29c85db533557f01c7fdb1
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX COLEC12 MAMDC2 LRP1

6.23e-0518053408ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX COLEC12 MAMDC2 LRP1

6.23e-051805349b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX COLEC12 MAMDC2 LRP1

6.36e-051815349e7d0f1afb8d9bc5a209ddb5314df3a25a0274d9
ToppCellfacs-Lung-nan-3m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COLEC12 MAMDC2 LRP1 FBXO30

6.50e-05182534c557de6ccd327c46e0a5423cd9936d78e0abae5f
ToppCellfacs-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COLEC12 MAMDC2 LRP1 FBXO30

6.50e-05182534dbe4b2557cf19e0682ed446f8397d3a1153642f0
ToppCellNS-critical-d_07-13-Epithelial-Ionocyte|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

COLEC12 TEAD2 UNC13C EPHA5

6.64e-05183534ba43bca2b45be1008eebd3f033cecb061fb3a966
ToppCellCOPD-Myeloid-Macrophage_Alveolar|World / Disease state, Lineage and Cell class

COLEC12 ASGR1 LRP1 STAC

6.78e-051845347fd0b227c3750ffb80e41e92c60fcce46656be14
ToppCellControl-Myeloid-Macrophage_Alveolar|World / Disease state, Lineage and Cell class

ASGR1 LRP1 GPNMB STAC

6.92e-0518553485cb81759589a26d83676cffbf2bc37399683c10
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAMDC2 GRIK1 CNTN6 EPHA5

7.07e-05186534d8d559daff4aeef334d403fde4e3ee2e4a6086d0
ToppCellControl-Endothelial-Endothelial-Vein|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CLSTN3 ADAMTS6 UNC13C NOS1

7.07e-0518653492092f11ecce22c14f244e42c499af0822977e6f
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.6.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COLEC12 GPNMB STAC CA1

7.22e-0518753453d41c86f57c00e6148a3eb73f42a842d78d50a1
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

UNC13C GRIK1 NOS1 CA1

7.37e-051885348268574584e5fb869a6cb8bbd7135cd7454a6a25
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

UNC13C GRIK1 NOS1 CA1

7.37e-051885344544552ebd67e9eb3e40d8511bb2b03a6e1178f8
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIA4 GRIK1 NOS1 CA1

7.37e-051885343139540a656c0436b2123ea50741ff8d00112165
ToppCellfacs-Lung-18m-Mesenchymal|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COLEC12 VLDLR MAMDC2 LRP1

7.52e-05189534bdf8db938aa0863c4fed6fa99dcffd63c8c20c31
ToppCellMacrophages-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

DTX4 LRP1 GPNMB STAC

7.52e-05189534c05b4b565c0ce56dbb45fc9503654a2ec1a7e1e9
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COLEC12 VLDLR MAMDC2 LRP1

7.52e-0518953440cbd679dc0548bf5207e1b033c0597886ad6fe1
ToppCellBAL-Severe-Myeloid-TRAM-TRAM1-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

COLEC12 LRP1 GPNMB STAC

7.68e-051905340eef5a8bd88ef8a25a67d9dd522d9472fa4b3d2f
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

UNC13C GRIK1 NOS1 CA1

7.68e-051905342f54da2bee411f8868348a4c37034184b8f58a89
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

UNC13C GRIK1 NOS1 CA1

7.68e-0519053459720dfe9de1b980807644536c919d2a02ba69dd
ToppCellBAL-Severe-Myeloid-TRAM-TRAM1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

COLEC12 LRP1 GPNMB STAC

7.68e-051905342724e8f375d8d9f5f2a77444e0491af264babac5
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX COLEC12 DTX4 LRP1

7.68e-0519053445df8fee00f8949937863159d7aa042e72748d9b
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_2|356C / Donor, Lineage, Cell class and subclass (all cells)

COLEC12 LRP1 GPNMB STAC

7.68e-051905344cce4ddb79b7751d0103e10f71156977e0c34439
ToppCellBAL-Severe-Myeloid-TRAM-TRAM1-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

COLEC12 LRP1 GPNMB STAC

7.68e-0519053411fbd4e9f02750354b3aadf30edc991f8d4f8f41
ToppCellBAL-Severe-Myeloid-TRAM-TRAM1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

COLEC12 LRP1 GPNMB STAC

7.68e-05190534148d43dd72e2e22b2cd68e17fedae6bd98b32aee
ToppCelldroplet-Fat-Gat-18m-Mesenchymal-Cd34+|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COLEC12 VLDLR LRP1 GPNMB

7.83e-051915346cab0334f76c973880bd8d1638856f2f6e4a249a
ToppCelldroplet-Fat-Gat-18m-Mesenchymal|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COLEC12 VLDLR LRP1 GPNMB

7.83e-05191534850c6fff6dc795431ef534fdaa41e4ad50f7367a
ToppCellSevere_COVID-19-Myeloid-TRAM1|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

COLEC12 LRP1 GPNMB STAC

7.83e-05191534bd641aab36276dd952a7265ee79ba455b38d8e6b
ToppCellP07-Mesenchymal-mesenchymal_fibroblast|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PHEX COLEC12 VLDLR LRP1

7.83e-05191534a05e9a7eb137d804570dd7d8905975d735738767
ToppCellControl-Stromal_mesenchymal|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX COLEC12 MAMDC2 LRP1

7.83e-0519153414057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCelldroplet-Fat-Gat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COLEC12 VLDLR LRP1 GPNMB

7.83e-051915348b2b00202d3c98bccbae1b4a23713892fad0ff23
ToppCellBAL-Severe-Myeloid-TRAM-TRAM3|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

COLEC12 DTX4 GPNMB STAC

7.83e-051915342b10a73c5d80e83d67a7121fb004a1aa86a537ef
ToppCellBAL-Severe-Myeloid-TRAM-TRAM3-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

COLEC12 DTX4 GPNMB STAC

7.83e-0519153402e1ae144da7274171e055356d10e8d175c5347f
ToppCellSevere_COVID-19-Myeloid-TRAM3|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

COLEC12 DTX4 GPNMB STAC

7.83e-0519153405867b96199a46a415848409130697c810d18937
ToppCellBAL-Severe-Myeloid-TRAM|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

COLEC12 DTX4 GPNMB STAC

7.83e-051915344c4f50a502e3f6768a89df686fa2830b83b8b33f
ToppCellBAL-Severe-Myeloid-TRAM|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

COLEC12 DTX4 GPNMB STAC

7.83e-05191534de7c88bb46f794291025ef121a89fcd94dea4ffe
ToppCellCOVID-19-lung-Macrophage_PPARGhi_CD5Lhi|lung / Disease (COVID-19 only), tissue and cell type

COLEC12 LRP1 GPNMB STAC

7.83e-05191534dab953682b8c9ed680a799161f837f792a7e4f33
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COLEC12 VLDLR MAMDC2 LRP1

7.83e-05191534997abf0cc5873bed0372c4a333ed307fa72774d2
ToppCellCOVID-19-lung-Macrophage_PPARGhi_CD5Lhi|COVID-19 / Disease (COVID-19 only), tissue and cell type

COLEC12 LRP1 GPNMB STAC

7.99e-05192534bcfb9c005166bc0b4f8ee2dfc0c1540e8bf0e1ff
ToppCelldroplet-Kidney-nan-18m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COLEC12 LRP1 GRIA4 GPNMB

7.99e-0519253438d7a24ae205ef91ed2e0f402d8022f2a9cdb243
ToppCellBAL-Severe-Myeloid-TRAM-TRAM3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

COLEC12 DTX4 GPNMB STAC

7.99e-0519253434505a13b8a47c9286c560122fa7861b9c331a08
ToppCelldroplet-Kidney-nan-18m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COLEC12 LRP1 GRIA4 GPNMB

7.99e-0519253404d155897ed075c359933080e36a4ab2150b6e9f
ToppCellCOVID-19-Myeloid-TRAM1|COVID-19 / Condition, Lineage and Cell class

COLEC12 DTX4 GPNMB STAC

7.99e-0519253452b8578699325b0d35a2d3ba36772096130ccc0c
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX COLEC12 DTX4 LRP1

7.99e-05192534f4fc2b0121f879bab2bee99dfb5ff2c3ca1c0e1b
ToppCellBAL-Severe-Myeloid-TRAM-TRAM3-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

COLEC12 DTX4 GPNMB STAC

7.99e-0519253457c1410ebf90c230993e065eb78385daa3360960
ToppCellSevere-Myeloid-Macrophages-FABP4+|Severe / Condition, Lineage, Cell class and cell subclass

COLEC12 DTX4 GPNMB STAC

7.99e-0519253430aad927ad40d8abaf9d0539bf8cb9d88d16f24d
DiseaseNephronophthisis 1

NPHP1 IQCB1

3.05e-062522C4551979
Diseaseepilepsy (implicated_via_orthology)

LRP1 CDYL UNC13C SLC12A7 NOS1

1.02e-05163525DOID:1826 (implicated_via_orthology)
Diseasenephronophthisis (is_implicated_in)

NPHP1 IQCB1

4.55e-056522DOID:12712 (is_implicated_in)
DiseaseRenal dysplasia and retinal aplasia

NPHP1 IQCB1

6.36e-057522cv:C0403553
DiseaseSenior-Loken syndrome (is_implicated_in)

NPHP1 IQCB1

6.36e-057522DOID:0050576 (is_implicated_in)
DiseaseRenal dysplasia and retinal aplasia (disorder)

NPHP1 IQCB1

1.99e-0412522C0403553
DiseaseMyopia

COL2A1 GRIA4

3.15e-0415522C0027092
Diseasematrix metalloproteinase 12 measurement

DYNC2H1 GRIA4

4.58e-0418522EFO_0010590
Diseaseneutrophil count

TBX19 VLDLR MYO1E DYNC2H1 STXBP5 UNC13C LCT SLC12A7 OTUD7B

6.29e-041382529EFO_0004833
Diseasenephrotic syndrome (biomarker_via_orthology)

VLDLR NOS1

8.20e-0424522DOID:1184 (biomarker_via_orthology)
Diseasecorpus collosum mid-posterior volume measurement

VLDLR UNC13C

8.90e-0425522EFO_0010300
Diseasemigraine disorder, pulse pressure measurement

DYNC2H1 LRP1

9.64e-0426522EFO_0005763, MONDO_0005277
DiseaseCiliopathies

NPHP1 DYNC2H1 IQCB1

9.75e-04110523C4277690
Diseaseplatelet crit

COL2A1 VLDLR MYO1E PRIM1 SLC12A7 FAM13B SPIN3

1.34e-03952527EFO_0007985
DiseaseAlzheimer's disease (is_implicated_in)

VLDLR LRP1 NOS1

1.65e-03132523DOID:10652 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
DQNGPWKWVDGTDYE

ASGR1

216

P07306
WQGWNKRIEYAPGAG

CLSTN3

246

Q9BQT9
WYPQPQIKWSDTKGE

BTN3A3

171

O00478
GDLGWIAFPKNGWEE

EPHA5

71

P54756
EKWWRGNGCPEEDNK

GRIK1

811

P39086
ENDWNEKLYPVWKRG

GPNMB

51

Q14956
APGKGVVWEWENDNG

DTX4

86

Q9Y2E6
WGKDGPQWKHDFLDN

ADAMTS6

116

Q9UKP5
PEWKSGDYWIDPNQG

COL2A1

1291

P02458
WNGPLGVFEWDAFAK

PGK2

336

P07205
WKADRPGNAAWNLAE

MAMDC2

276

Q7Z304
FAVDPGKGWEWGKDD

OTUD7B

391

Q6GQQ9
KWGQKGGPWEFNLRD

MDN1

1936

Q9NU22
DPEWWKCKNARGQVG

NCK2

231

O43639
WMGDNLYWTDDGPKK

LRP1

611

Q07954
GDKWEEPFPAFKSWQ

FAM13B

476

Q9NYF5
GEPPEAGWDYAQWKQ

CCDC9B

226

Q6ZUT6
NKWWYDKGECGPKDS

GRIA4

786

P48058
DYKNWKAGQPDNWGH

COLEC12

686

Q5KU26
AWDADGKGPSIWDNF

LCT

921

P09848
AVDPGKDWEWGKDDN

OTUD7A

401

Q8TE49
EKNNPKKASWTWGPE

PADI2

131

Q9Y2J8
GLQEYEEWKWGKNPT

NOS1

1136

P29475
NNIKNDKYGPWLEWE

PRIM1

281

P49642
EDLWRWQKQNPSGFG

GALE

331

Q14376
AWQSKWEGPEDPLQY

DYNC2H1

4126

Q8NCM8
WGKSRKKNWQYEGPT

CDYL

11

Q9Y232
EKGSSWRNWPGEAKA

FAM193B

791

Q96PV7
WGYDDKNGPEQWSKL

CA1

6

P00915
NKEDPDWWKGEVNGQ

ITSN1

1186

Q15811
DWWKGEVNGQVGLFP

ITSN1

1191

Q15811
ASGKPNPWYTWLKNG

CNTN6

341

Q9UQ52
QAPWWKKLGEESGDE

IQCB1

561

Q15051
FEPDREKKWWQSENG

LAMB4

96

A4D0S4
WGKRKYPEGNSSWQI

FBXO30

661

Q8TB52
PGQNWVKTADGWKRF

FBXO32

11

Q969P5
PASWKQEDNPFSWKN

SLC12A7

796

Q9Y666
PDGWWIAKDAKGNEG

NPHP1

186

O15259
KKQGPWATYAAIEWD

SMCHD1

591

A6NHR9
KFWADLNWGPSGEEA

TEAD2

301

Q15562
QGYSKKEWPINGGNW

STXBP5

426

Q5T5C0
PWKPKYFIQEGDGWV

OSBPL10

741

Q9BXB5
NGGWPSGWEKKEEFV

SLC17A6

551

Q9P2U8
KNGREFSLWDPGQVW

RIBC1

106

Q8N443
PWKEWNQGADLGLDS

UNC13C

656

Q8NB66
HGWKDGDEPLTQWKG

SPIN3

56

Q5JUX0
DWWKGKIQDRIGFFP

STAC

321

Q99469
WDYPGKQAERGKWVP

FLT4

266

P35916
AKGQELQPWTPADWK

TREH

96

O43280
RKYDKNGNLDPWWST

PHEX

591

P78562
WKYVNGEWVPAGKPE

TBX19

101

O60806
KQWGTPDRKLFWGNQ

THEGL

191

P0DJG4
LGEDLQWWPDKDGTK

UBR5

356

O95071
YWSDWGEPAKIEKAG

VLDLR

571

P98155
LKKENWGPWSAGGSR

MYO1E

881

Q12965