Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor binding	HSPG2 DAB2 PICALM WASH6P	6.84e-05	34	130	4	GO:0050750
GeneOntologyMolecularFunction	lipoprotein particle receptor binding	HSPG2 DAB2 PICALM WASH6P	1.18e-04	39	130	4	GO:0070325
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	PCDHA9 NRCAM PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1 HMCN2 CELSR3 HMCN1 PLXNB3	2.26e-08	187	127	11	GO:0007156
GeneOntologyBiologicalProcess	cell-cell adhesion via plasma-membrane adhesion molecules	PCDHA9 NRCAM PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1 HMCN2 CELSR3 HMCN1 PLXNB3	3.84e-06	313	127	11	GO:0098742
GeneOntologyCellularComponent	Schwann cell microvillus	NFASC AKR1B1	1.13e-04	3	129	2	GO:0097454
MousePheno	abnormal node of Ranvier morphology	HSPG2 SH3TC2 NRCAM	3.84e-06	5	103	3	MP:0010732
Domain	Cadherin_tail	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1	1.64e-07	37	126	6	PF15974
Domain	Cadherin_CBD	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1	1.64e-07	37	126	6	IPR031904
Domain	Cadherin_2	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1	4.99e-06	65	126	6	PF08266
Domain	Cadherin_N	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1	4.99e-06	65	126	6	IPR013164
Domain	Cadherin_CS	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1 CELSR3	9.06e-06	109	126	7	IPR020894
Domain	CADHERIN_1	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1 CELSR3	1.15e-05	113	126	7	PS00232
Domain	Cadherin	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1 CELSR3	1.15e-05	113	126	7	PF00028
Domain	CADHERIN_2	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1 CELSR3	1.22e-05	114	126	7	PS50268
Domain	-	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1 CELSR3	1.22e-05	114	126	7	2.60.40.60
Domain	CA	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1 CELSR3	1.29e-05	115	126	7	SM00112
Domain	Cadherin-like	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1 CELSR3	1.36e-05	116	126	7	IPR015919
Domain	Cadherin	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1 CELSR3	1.53e-05	118	126	7	IPR002126
Domain	M_domain	TNRC6C TNRC6A	4.52e-05	2	126	2	PF12938
Domain	GW182_M_dom	TNRC6C TNRC6A	4.52e-05	2	126	2	IPR026805
Domain	Ago_hook	TNRC6C TNRC6A	1.35e-04	3	126	2	PF10427
Domain	BAT2_N	PRRC2C PRRC2B	1.35e-04	3	126	2	PF07001
Domain	TNRC6_PABC-bd	TNRC6C TNRC6A	1.35e-04	3	126	2	IPR032226
Domain	Argonaute_hook_dom	TNRC6C TNRC6A	1.35e-04	3	126	2	IPR019486
Domain	BAT2_N	PRRC2C PRRC2B	1.35e-04	3	126	2	IPR009738
Domain	TNRC6-PABC_bdg	TNRC6C TNRC6A	1.35e-04	3	126	2	PF16608
Domain	PRRC2	PRRC2C PRRC2B	1.35e-04	3	126	2	IPR033184
Domain	Neurofascin/L1/NrCAM_C	NRCAM NFASC	2.69e-04	4	126	2	IPR026966
Domain	G2F	HMCN2 HMCN1	2.69e-04	4	126	2	PF07474
Domain	Helicase_C_2	BRIP1 RTEL1	2.69e-04	4	126	2	PF13307
Domain	DEAD_2	BRIP1 RTEL1	2.69e-04	4	126	2	PF06733
Domain	DEAD_2	BRIP1 RTEL1	2.69e-04	4	126	2	IPR010614
Domain	ATP-dep_Helicase_C	BRIP1 RTEL1	2.69e-04	4	126	2	IPR006555
Domain	Helicase-like_DEXD_c2	BRIP1 RTEL1	2.69e-04	4	126	2	IPR006554
Domain	DNA_helicase_DNA-repair_Rad3	BRIP1 RTEL1	2.69e-04	4	126	2	IPR013020
Domain	NIDOGEN_G2	HMCN2 HMCN1	2.69e-04	4	126	2	PS50993
Domain	GFP	HMCN2 HMCN1	2.69e-04	4	126	2	IPR009017
Domain	Bravo_FIGEY	NRCAM NFASC	2.69e-04	4	126	2	PF13882
Domain	HELICASE_ATP_BIND_2	BRIP1 RTEL1	2.69e-04	4	126	2	PS51193
Domain	Helic_SF1/SF2_ATP-bd_DinG/Rad3	BRIP1 RTEL1	2.69e-04	4	126	2	IPR014013
Domain	G2_nidogen/fibulin_G2F	HMCN2 HMCN1	2.69e-04	4	126	2	IPR006605
Domain	DEXDc2	BRIP1 RTEL1	2.69e-04	4	126	2	SM00488
Domain	HELICc2	BRIP1 RTEL1	2.69e-04	4	126	2	SM00491
Domain	NUT	NUTM2A NUTM2B	4.46e-04	5	126	2	IPR024310
Domain	NUT_N	NUTM2A NUTM2B	4.46e-04	5	126	2	IPR024309
Domain	NUT	NUTM2A NUTM2B	4.46e-04	5	126	2	PF12881
Domain	fn3	NRCAM NFASC CSF3R PTPRK LRRN4 OSMR	8.12e-04	162	126	6	PF00041
Domain	Hematopoietin_rcpt_Gp130_CS	CSF3R OSMR	9.27e-04	7	126	2	IPR003529
Domain	HEMATOPO_REC_L_F2	CSF3R OSMR	1.23e-03	8	126	2	PS01353
Domain	NHL_repeat_subgr	NHLRC1 NHLRC2	1.58e-03	9	126	2	IPR013017
Domain	FN3	NRCAM NFASC CSF3R PTPRK LRRN4 OSMR	1.61e-03	185	126	6	SM00060
Domain	Ig_I-set	HSPG2 NRCAM NFASC HMCN2 HMCN1 PTPRK	1.84e-03	190	126	6	IPR013098
Domain	I-set	HSPG2 NRCAM NFASC HMCN2 HMCN1 PTPRK	1.84e-03	190	126	6	PF07679
Domain	NHL_repeat	NHLRC1 NHLRC2	1.96e-03	10	126	2	IPR001258
Domain	NHL	NHLRC1 NHLRC2	1.96e-03	10	126	2	PF01436
Domain	LAM_G_DOMAIN	HSPG2 COL24A1 CELSR3	2.13e-03	38	126	3	PS50025
Domain	FN3	NRCAM NFASC CSF3R PTPRK LRRN4 OSMR	2.32e-03	199	126	6	PS50853
Domain	Laminin_G_2	HSPG2 COL24A1 CELSR3	2.47e-03	40	126	3	PF02210
Domain	calpain_III	CAPN10 CAPN8	2.85e-03	12	126	2	SM00720
Domain	C2_III	CAPN10 CAPN8	2.85e-03	12	126	2	IPR033883
Domain	Calpain_III	CAPN10 CAPN8	2.85e-03	12	126	2	IPR022683
Domain	DUF4599	SPATA31E1 SPATA31C1	2.85e-03	12	126	2	PF15371
Domain	DUF4599	SPATA31E1 SPATA31C1	2.85e-03	12	126	2	IPR027970
Domain	FN3_dom	NRCAM NFASC CSF3R PTPRK LRRN4 OSMR	2.96e-03	209	126	6	IPR003961
Domain	Calpain_III	CAPN10 CAPN8	3.35e-03	13	126	2	PF01067
Domain	Calpain_domain_III	CAPN10 CAPN8	3.35e-03	13	126	2	IPR022682
Domain	NHL	NHLRC1 NHLRC2	3.35e-03	13	126	2	PS51125
Domain	Calpain_cysteine_protease	CAPN10 CAPN8	3.90e-03	14	126	2	IPR022684
Domain	Peptidase_C2	CAPN10 CAPN8	4.48e-03	15	126	2	PF00648
Domain	CysPc	CAPN10 CAPN8	4.48e-03	15	126	2	SM00230
Domain	Peptidase_C2_calpain_cat	CAPN10 CAPN8	4.48e-03	15	126	2	IPR001300
Domain	CALPAIN_CAT	CAPN10 CAPN8	4.48e-03	15	126	2	PS50203
Domain	Guanylate_kinase_CS	MAGI3 DLG3	5.09e-03	16	126	2	IPR020590
Domain	Sulfatase_CS	ARSJ ARSG	5.09e-03	16	126	2	IPR024607
Domain	SULFATASE_1	ARSJ ARSG	5.75e-03	17	126	2	PS00523
Domain	SULFATASE_2	ARSJ ARSG	5.75e-03	17	126	2	PS00149
Domain	Sulfatase	ARSJ ARSG	6.44e-03	18	126	2	PF00884
Domain	Sulfatase_N	ARSJ ARSG	6.44e-03	18	126	2	IPR000917
Pubmed	Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1	1.36e-11	15	133	6	15640798
Pubmed	Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1	3.34e-11	17	133	6	29911975
Pubmed	CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1	4.99e-11	18	133	6	15570159
Pubmed	Genomic organization of the family of CNR cadherin genes in mice and humans.	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1	4.99e-11	18	133	6	10662547
Pubmed	Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1	3.55e-10	24	133	6	24698270
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1	9.81e-10	28	133	6	15347688
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	PCDHA9 DTX1 DAB2 NFASC PCDHA8 PCDHA6 PCDHA3 PCDHA1 ASAP1 CELSR3 SLC24A1 FYB1	5.80e-09	329	133	12	17474147
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1 CELSR3	1.22e-08	72	133	7	10380929
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1 CELSR3	2.57e-08	80	133	7	10716726
Pubmed	Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.	PCDHA9 PCDHA13 PCDHA8 PCDHA6	6.61e-08	11	133	4	9655502
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1	8.63e-08	57	133	6	32633719
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1	9.60e-08	58	133	6	30377227
Pubmed	Proteins of the CNR family are multiple receptors for Reelin.	PCDHA9 PCDHA13 PCDHA8 PCDHA6	9.88e-08	12	133	4	10612399
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1	2.52e-07	68	133	6	11230163
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1	4.18e-07	74	133	6	10817752
Pubmed	The DNA sequence and comparative analysis of human chromosome 5.	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1	4.53e-07	75	133	6	15372022
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1	5.30e-07	77	133	6	10835267
Pubmed	Genetic effects on carotid intima-media thickness: systematic assessment and meta-analyses of candidate gene polymorphisms studied in more than 5000 subjects.	ADD1 MTHFR NOS3	5.44e-07	5	133	3	20160191
Pubmed	Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.	PCDHA9 DTX1 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1 MYO3B	8.43e-07	193	133	8	22589738
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HSPG2 ARSJ ACACA RHOT2 TNRC6C MAPKAPK5 ARSG ZNF263 TNRC18 CELSR3 MTHFR HPS6 TXNRD3 PCYT2 SNAPC4 PRRC2B AHNAK2	1.17e-06	1105	133	17	35748872
Pubmed	Risks of human conotruncal heart defects associated with 32 single nucleotide polymorphisms of selected cardiovascular disease-related genes.	ADD1 MTHFR NOS3	3.02e-06	8	133	3	16100725
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NRCAM TNRC6C ASAP1 KLHL29 PRRC2C DOCK7 GIGYF2 DLG3 PLXNB3 PRRC2B	4.06e-06	407	133	10	12693553
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	ACACA TARS2 ADD1 ALMS1 PRRC2C TNRC6A GIGYF2 PRRC2B	4.54e-06	242	133	8	34011540
Pubmed	Identifying genetic susceptibilities to diabetes-related complications among individuals at low risk of complications: An application of tree-structured survival analysis.	MTHFR AKR1B1 NOS3	6.43e-06	10	133	3	16928730
Pubmed	A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1	6.80e-06	119	133	6	28625976
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	NRCAM MAGI3 HSPA12A CELSR3 ALMS1 PLXNB3	1.13e-05	130	133	6	12421765
Pubmed	Polymorphic variations in manganese superoxide dismutase (MnSOD) and endothelial nitric oxide synthase (eNOS) genes contribute to the development of type 2 diabetes mellitus in the Chinese Han population.	NOS3 SOD2	1.45e-05	2	133	2	26505452
Pubmed	Association of MTHFR and PICALM polymorphisms with Alzheimer's disease.	PICALM MTHFR	1.45e-05	2	133	2	25359311
Pubmed	Associations between prenatal exposure to cadmium and lead with neural tube defect risks are modified by single-nucleotide polymorphisms of fetal MTHFR and SOD2: a case-control study.	MTHFR SOD2	1.45e-05	2	133	2	34090432
Pubmed	A novel multiplex PCR-RFLP method for simultaneous detection of the MTHFR 677 C > T, eNOS +894 G > T and - eNOS -786 T > C variants among Malaysian Malays.	MTHFR NOS3	1.45e-05	2	133	2	22594584
Pubmed	Neurofascin induces neurites by heterophilic interactions with axonal NrCAM while NrCAM requires F11 on the axonal surface to extend neurites.	NRCAM NFASC	1.45e-05	2	133	2	8922386
Pubmed	Methylentetrahydrofolate reductase and nitric oxide synthase polymorphism in patients with atherosclerosis and diabetes.	MTHFR NOS3	1.45e-05	2	133	2	19330466
Pubmed	The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice.	TF PICALM	1.45e-05	2	133	2	22363754
Pubmed	Low folate levels may be an atherogenic factor regardless of homocysteine levels in young healthy nonsmokers.	MTHFR NOS3	1.45e-05	2	133	2	19913857
Pubmed	No association of C677T methylenetetrahydrofolate reductase and an endothelial nitric oxide synthase polymorphism with recurrent pregnancy loss.	MTHFR NOS3	1.45e-05	2	133	2	15214944
Pubmed	Disinhibition of SOD-2 expression to compensate for a genetically determined NO deficit in endothelial cells--brief report.	NOS3 SOD2	1.45e-05	2	133	2	19696404
Pubmed	Manganese superoxide dismutase gene polymorphism (V16A) is associated with diabetic retinopathy in Slovene (Caucasians) type 2 diabetes patients.	NOS3 SOD2	1.45e-05	2	133	2	18057537
Pubmed	The 894G>T variant in the endothelial nitric oxide synthase gene and spina bifida risk.	MTHFR NOS3	1.45e-05	2	133	2	17479212
Pubmed	Impaired vasorelaxation in inbred mice is associated with alterations in both nitric oxide and super oxide pathways.	NOS3 SOD2	1.45e-05	2	133	2	17664889
Pubmed	Association between Glu298Asp/677C-T single nucleotide polymorphism in the eNOS/MTHRF gene and blood stasis syndrome of ischemic stroke.	MTHFR NOS3	1.45e-05	2	133	2	22940147
Pubmed	[Polymorphisms of α-2-β-adrenergic receptor and endothelial NO-synthase genes in patients with atrial fibrillation].	ADRA2B NOS3	1.45e-05	2	133	2	21942960
Pubmed	Clinical Relevance of MTHFR, eNOS, ACE, and ApoE Gene Polymorphisms and Serum Vitamin Profile among Malay Patients with Ischemic Stroke.	MTHFR NOS3	1.45e-05	2	133	2	26187788
Pubmed	Mammalian hemicentin 1 is assembled into tracks in the extracellular matrix of multiple tissues.	HMCN2 HMCN1	1.45e-05	2	133	2	32035013
Pubmed	[Polymorphisms of 2B-adrenergic receptor and endothelial NO-Synthase genes in genesis of the hereditary sick sinus node syndrome].	ADRA2B NOS3	1.45e-05	2	133	2	21878072
Pubmed	[Polimorfismos asociados a disfunción endotelial y a un estado protrombótico en jóvenes mexicanos con infarto cerebral].	MTHFR NOS3	1.45e-05	2	133	2	30532099
Pubmed	Intron-less processed Pcdhalpha genes in the central nervous system.	PCDHA8 PCDHA6	1.45e-05	2	133	2	14697259
Pubmed	Interaction of eNOS polymorphism with MTHFR variants increase the risk of diabetic nephropathy and its progression in type 2 diabetes mellitus patients.	MTHFR NOS3	1.45e-05	2	133	2	21380725
Pubmed	Endothelial nitric oxide synthetase, methylenetetrahydrofolate reductase polymorphisms, and cardiovascular complications in Tunisian patients with nondiabetic renal disease.	MTHFR NOS3	1.45e-05	2	133	2	19376104
Pubmed	The 894G > T (Glu298Asp) variant in the endothelial NOS gene and MTHFR polymorphisms influence homocysteine levels in patients with cognitive decline.	MTHFR NOS3	1.45e-05	2	133	2	21607713
Pubmed	NOS3 Inhibition Confers Post-Ischemic Protection to Young and Aging White Matter Integrity by Conserving Mitochondrial Dynamics and Miro-2 Levels.	RHOT2 NOS3	1.45e-05	2	133	2	29891729
Pubmed	Autoimmunity in membranous nephropathy targets aldose reductase and SOD2.	AKR1B1 SOD2	1.45e-05	2	133	2	20150532
Pubmed	Effects of six functional SNPs on the urinary 8-isoprostane level in a general Japanese population; Shimane COHRE Study.	MTHFR NOS3	1.45e-05	2	133	2	21725157
Pubmed	Association between SOD2 T-9C and MTHFR C677T polymorphisms and longevity: a study in Jordanian population.	MTHFR SOD2	1.45e-05	2	133	2	20003469
Pubmed	Alu RNA accumulation in hyperglycemia augments oxidative stress and impairs eNOS and SOD2 expression in endothelial cells.	NOS3 SOD2	1.45e-05	2	133	2	26891959
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	ACACA DAB2 PICALM ADD1 ALMS1 TNRC6A DOCK7	1.68e-05	209	133	7	36779422
Pubmed	[Association of genetic factors with clinical peculiarities of hypertensive disease in patients with burdened familial anamnesis].	MTHFR NOS3 SOD2	1.93e-05	14	133	3	19254215
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	NCOA2 TPRN TNRC6C ALMS1 TNRC6A PRRC2B	2.74e-05	152	133	6	38360978
Pubmed	Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere.	HMCN2 HMCN1	4.34e-05	3	133	2	12388743
Pubmed	[Remodeling of the cardiovascular system and development of chronic kidney disease in patients with metabolic syndrome and obesity: role of eNOS, subunit p22-phox of NADPH-oxidase and MTHFR genes].	MTHFR NOS3	4.34e-05	3	133	2	22997914
Pubmed	Increased renal oxidative stress in salt-sensitive human GRK4γ486V transgenic mice.	NOS3 SOD2	4.34e-05	3	133	2	28189851
Pubmed	A TEAD1/p65 complex regulates the eutherian-conserved MnSOD intronic enhancer, eRNA transcription and the innate immune response.	TEAD1 SOD2	4.34e-05	3	133	2	24953189
Pubmed	Endothelial nitric oxide synthase and methylenetetrahydrofolate reductase gene polymorphisms are associated with endothelial dysfunction in young, healthy men.	MTHFR NOS3	4.34e-05	3	133	2	15494775
Pubmed	Lack of associations between polymorphisms in SOD2 (rs2758331), NOS3 (rs1808593), PPARδ (rs9794 and rs10865710) and the risk of osteoarthritis in a Chinese Han population: a case-control study.	NOS3 SOD2	4.34e-05	3	133	2	30839355
Pubmed	Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS gene polymorphisms in atrial fibrillation susceptibility.	MTHFR NOS3	4.34e-05	3	133	2	17551576
Pubmed	Association of acute ischemic stroke with the MTHFR C677T polymorphism but not with NOS3 gene polymorphisms in a Singapore population.	MTHFR NOS3	4.34e-05	3	133	2	19049547
Pubmed	Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.	TNRC6C TNRC6A	4.34e-05	3	133	2	31670606
Pubmed	Stromelysin-1 5A/6A and eNOS T-786C polymorphisms, MTHFR C677T and A1298C mutations, and cigarette-cannabis smoking: a pilot, hypothesis-generating study of gene-environment pathophysiological associations with Buerger's disease.	MTHFR NOS3	4.34e-05	3	133	2	17000887
Pubmed	The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney.	NUTM2E NUTM2B	4.34e-05	3	133	2	26542179
Pubmed	A secreted protein promotes cleavage furrow maturation during cytokinesis.	HMCN2 HMCN1	4.34e-05	3	133	2	21215633
Pubmed	The coagulation factor V Leiden, MTHFRC677T variant and eNOS 4ab polymorphism in young Chinese population with ischemic stroke.	MTHFR NOS3	4.34e-05	3	133	2	18602910
Pubmed	Expression of Mn-SOD, iNOS and eNOS mRNAs in osteoblasts from the maxilla of osteopetrotic mice.	NOS3 SOD2	4.34e-05	3	133	2	22783967
Pubmed	The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor.	NUTM2A NUTM2B	4.34e-05	3	133	2	22456610
Pubmed	[Genetic determinants of hypertension in two national cohorts of Mountain Shoria].	ADRA2B MTHFR	4.34e-05	3	133	2	29039833
Pubmed	The impact of eNOS, MTR and MTHFR polymorphisms on renal graft survival in children and young adults.	MTHFR NOS3	4.34e-05	3	133	2	19349296
Pubmed	Association between genetic and environmental factors and the risk of Alzheimer's disease.	MTHFR NOS3	4.34e-05	3	133	2	19169966
Pubmed	Mthfr deficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1.	MTHFR NOS3	4.34e-05	3	133	2	21169404
Pubmed	[Endothelial dysfunction gene polymorphisms and the rate of liver fibrosis in chronic hepatitis C].	MTHFR NOS3	4.34e-05	3	133	2	24864467
Pubmed	Interaction among 5,10 methylenetetrahydrofolate reductase, plasminogen activator inhibitor and endothelial nitric oxide synthase gene polymorphisms predicts the severity of coronary artery disease in Turkish patients.	MTHFR NOS3	4.34e-05	3	133	2	16845248
Pubmed	Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.	TNRC6C TNRC6A	4.34e-05	3	133	2	34108231
Pubmed	Hemicentins assemble on diverse epithelia in the mouse.	HMCN2 HMCN1	4.34e-05	3	133	2	17015624
Pubmed	IDH2 deficiency impairs mitochondrial function in endothelial cells and endothelium-dependent vasomotor function.	NOS3 SOD2	4.34e-05	3	133	2	26898144
Pubmed	Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.	TNRC6C TNRC6A	4.34e-05	3	133	2	16880270
Pubmed	[Prognostic value of allelic variants affecting the hemostatic system in the development of antiphospholipid syndrome and kidney lesion in patients with systemic lupus erythematosus].	MTHFR NOS3	4.34e-05	3	133	2	25095657
Pubmed	Endothelial nitric oxide synthase gene interactions and the risk of ischaemic stroke.	MTHFR NOS3	4.34e-05	3	133	2	15595935
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	SPATA31E1 DTX1 DAB2 GRM1 PICALM ASAP1 ZNF469 TNRC18 TSHZ1	4.38e-05	430	133	9	35044719
Pubmed	Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction.	NRCAM TF GLCE OSMR SOD2	5.39e-05	105	133	5	24667918
Pubmed	Candidate genes and cerebral palsy: a population-based study.	ADD1 MTHFR NOS3	6.91e-05	21	133	3	18977990
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	DMGDH AFF3 NUTM2D RHOT2 NHLRC2 ARSG NUTM2E COL24A1 MECR NUTM2B DLG3 MRNIP SNAPC4 PLXNB3 PRRC2B	8.52e-05	1242	133	15	30973865
Pubmed	Effect modification by smoking on the association between genetic polymorphisms in oxidative stress genes and colorectal cancer risk.	NOS3 SOD2	8.67e-05	4	133	2	19622717
Pubmed	The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets.	TNRC6C TNRC6A	8.67e-05	4	133	2	23172285
Pubmed	Expression of four immunoglobulin superfamily adhesion molecules (L1, Nr-CAM/Bravo, neurofascin/ABGP, and N-CAM) in the developing mouse spinal cord.	NRCAM NFASC	8.67e-05	4	133	2	7706555
Pubmed	Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing.	TNRC6C TNRC6A	8.67e-05	4	133	2	21063388
Pubmed	Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein.	TNRC6C TNRC6A	8.67e-05	4	133	2	20181956
Pubmed	Severity of Demyelinating and Axonal Neuropathy Mouse Models Is Modified by Genes Affecting Structure and Function of Peripheral Nodes.	SH3TC2 NRCAM	8.67e-05	4	133	2	28355569
Pubmed	Polymorphisms in genes related to oxidative stress (CAT, MnSOD, MPO, and eNOS) and acute toxicities from radiation therapy following lumpectomy for breast cancer.	NOS3 SOD2	8.67e-05	4	133	2	17145829
Pubmed	Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments.	NRCAM NFASC	8.67e-05	4	133	2	11724816
Pubmed	Vertebrate extracellular matrix protein hemicentin-1 interacts physically and genetically with basement membrane protein nidogen-2.	HMCN2 HMCN1	8.67e-05	4	133	2	36007682
Pubmed	Genetic polymorphisms of oxidative and antioxidant enzymes and arsenic-related hypertension.	NOS3 SOD2	8.67e-05	4	133	2	16076760
Pubmed	Selected gene polymorphisms and their interaction with maternal smoking, as risk factors for gastroschisis.	ADD1 NOS3	8.67e-05	4	133	2	17051589
Pubmed	Structural and functional evolution of the L1 family: are four adhesion molecules better than one?	NRCAM NFASC	8.67e-05	4	133	2	10662501
Interaction	PCDHA3 interactions	PCDHA9 GHDC PCDHA8 PCDHA6 PCDHA3 PCDHA1	6.78e-08	34	128	6	int:PCDHA3
Interaction	PCDHA10 interactions	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3	2.31e-07	22	128	5	int:PCDHA10
Interaction	PCDHA8 interactions	PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1 OSMR	1.31e-06	55	128	6	int:PCDHA8
Interaction	PCDHA6 interactions	PCDHA8 PCDHA6 PCDHA3	2.04e-05	9	128	3	int:PCDHA6
Interaction	PCDHA1 interactions	PCDHA8 PCDHA3 PCDHA1	2.04e-05	9	128	3	int:PCDHA1
Cytoband	5q31	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1	1.15e-06	115	133	6	5q31
Cytoband	10q26.12	HSPA12A LINC01561	1.73e-04	7	133	2	10q26.12
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1	2.45e-04	298	133	6	chr5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr9q34	TPRN SH2D3C HMCN2 PNPLA7 SNAPC4 PRRC2B	3.88e-04	325	133	6	chr9q34
Cytoband	10q23.2	NUTM2A NUTM2D	1.10e-03	17	133	2	10q23.2
Cytoband	5p13.1	OSMR FYB1	1.24e-03	18	133	2	5p13.1
Cytoband	12q24.13	DTX1 MAPKAPK5	2.39e-03	25	133	2	12q24.13
GeneFamily	Clustered protocadherins	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1	5.07e-07	64	84	6	20
GeneFamily	Ataxins\|Trinucleotide repeat containing	TNRC6C TNRC18 TNRC6A GIGYF2	5.09e-06	25	84	4	775
GeneFamily	Fibronectin type III domain containing	NRCAM NFASC CSF3R PTPRK PTPRQ LRRN4 OSMR	9.53e-06	160	84	7	555
GeneFamily	Fibulins	HMCN2 HMCN1	5.86e-04	8	84	2	556
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	HSPG2 NRCAM NFASC HMCN2 HMCN1	9.22e-04	161	84	5	593
GeneFamily	C2 domain containing\|Calpains	CAPN10 CAPN8	2.15e-03	15	84	2	975
GeneFamily	DNA helicases	BRIP1 RTEL1	2.77e-03	17	84	2	1167
GeneFamily	Sulfatases	ARSJ ARSG	3.11e-03	18	84	2	410
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRK PTPRQ	4.23e-03	21	84	2	813
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND3 SMCR8	5.97e-03	25	84	2	504
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	MAGI3 DLG3	6.45e-03	26	84	2	904
Coexpression	PEDRIOLI_MIR31_TARGETS_DN	SH3TC2 CWF19L2 NRCAM EMILIN2 PCDHA13 SMPDL3B CSF3R GVINP1 PNPLA7 CFAP70 PLXNB3 SOD2	1.38e-06	413	133	12	M2494
Coexpression	CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN	ARSJ ELP5 DAB2 EMILIN2 ADAMTS5 TEAD1 PICALM ASAP1 KLHL29 OSMR AKR1B1 AHNAK2	4.66e-06	465	133	12	M9192
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ACACA AFF3 MFSD4A MAGI3 CAPN8 PTPRK TMEM108	8.10e-07	170	133	7	a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NRCAM DTX1 MFSD4A GRM1 USP2 HMCN1 MYO3B	1.10e-06	178	133	7	4df6218b20c2f076c22346d23260964cc0d73e65
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ACACA AFF3 MFSD4A MAGI3 CAPN8 PTPRK TMEM108	1.10e-06	178	133	7	f5ed4a6e3eb8056b1be1fb311021710c95bdf888
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Adult / Lineage, Cell type, age group and donor	ACACA AFF3 MFSD4A MAGI3 CAPN8 PTPRK TMEM108	1.43e-06	185	133	7	673f0c688ae6984bc8027df2da335787924f4137
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ACACA AFF3 MFSD4A MAGI3 CAPN8 PTPRK TMEM108	1.43e-06	185	133	7	98b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	ACACA AFF3 MAGI3 TEAD1 CAPN8 PTPRK OSMR	1.83e-06	192	133	7	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DTX1 MFSD4A GRM1 USP2 COL24A1 FECH CFAP70	1.83e-06	192	133	7	ee27d27e3d269764dbe8711d0b37ff9331a298a9
ToppCell	Caecum-B_cell-B_cell_IgG_Plasma\|B_cell / Region, Cell class and subclass	NCOA2 ABRA GRM1 CELSR3 RTP5 DQX1 NOS3	2.17e-06	197	133	7	40c8ff067e8242e2ca083ea04cd6026168191a97
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-B_cells-Pro-B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DTX1 AFF3 SH2D3C RTP5 PNPLA7 SOD2	1.15e-05	168	133	6	c833e3311af2582787d3ff2ad59d802fff865f8f
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D231\|Adult / Lineage, Cell type, age group and donor	ACACA MFSD4A MAGI3 CAPN8 PTPRK TMEM108	1.23e-05	170	133	6	269dee5abca9f6aa079f116f0d8f1d198604d9d4
ToppCell	facs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DTX1 RDH5 MFSD4A PCDHA8 RNF207 NOS3	1.50e-05	176	133	6	460cb302c5b3d609c65b924e1d4e8ea057a68485
ToppCell	Control-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HSPG2 MAGI3 DENND3 MYO3B PTPRQ RNF207	1.54e-05	177	133	6	9af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCell	droplet-Liver-LIVER_HEP-30m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 MFSD4A DENND3 HSPA12A GVINP1 PRRC2C	1.70e-05	180	133	6	dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	ACACA AFF3 MAGI3 CAPN8 CSF3R PTPRK	1.70e-05	180	133	6	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	droplet-Liver-LIVER_HEP\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 MFSD4A DENND3 HSPA12A GVINP1 PRRC2C	1.70e-05	180	133	6	423454e3390080ae03bb3cbb267255ebfe4df080
ToppCell	COPD-Epithelial-Basal\|World / Disease state, Lineage and Cell class	ARSJ TEAD1 CAPN8 PTPRK PTPRQ OSMR	1.75e-05	181	133	6	6d8a886b4afe729f8a05b9c0f4ea9375de735da4
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRCAM GRM1 CAPN8 COL24A1 HMCN1 PTPRQ	1.92e-05	184	133	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	COVID-19-Epithelial_cells-AT2\|COVID-19 / group, cell type (main and fine annotations)	ACACA AFF3 MAGI3 CAPN8 CSF3R PTPRK	1.92e-05	184	133	6	369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCell	facs-Heart-RV-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXS1 RDH5 HSPA12A ADRA2B AOC3 TXNRD3	1.92e-05	184	133	6	9c20b50f8d6ac689d41d5440c835f9db8d04758b
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARSJ ADAMTS5 TEAD1 CFAP70 OSMR NOS3	1.92e-05	184	133	6	f506d0ee48f39d6f59f19554217dfdf0987cc405
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARSJ ADAMTS5 TEAD1 CFAP70 OSMR NOS3	1.92e-05	184	133	6	8bcb1c4bc8ffef74338cdade926a94711de93c64
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRCAM GRM1 CAPN8 COL24A1 HMCN1 PTPRQ	1.92e-05	184	133	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRCAM GRM1 CAPN8 COL24A1 HMCN1 PTPRQ	1.92e-05	184	133	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Heart-RV-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXS1 RDH5 HSPA12A ADRA2B AOC3 TXNRD3	1.92e-05	184	133	6	31dbe6119a3bcd266ae5e9b340c853d9ff680dce
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ACACA MFSD4A MAGI3 CAPN8 PTPRK OSMR	1.92e-05	184	133	6	102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXS1 ADAMTS5 AOC3 DOCK7 DLG3 SNAPC4	1.98e-05	185	133	6	38486b69c48dc5e1c4e1488208fa8954a973eccb
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXS1 ADAMTS5 AOC3 DOCK7 DLG3 SNAPC4	1.98e-05	185	133	6	3c28b5ceba3cfdb6f7e32d5b42e03b6a81a7a658
ToppCell	Control-Epithelial-Club\|World / Disease state, Lineage and Cell class	MAGI3 TEAD1 CAPN8 PTPRK TMEM108 OSMR	2.04e-05	186	133	6	9798428691408e17ff2af2fe2d1b345f074d67e4
ToppCell	LV-10._Endothelium_II\|World / Chamber and Cluster_Paper	HSPG2 SH2D3C ADD1 ASAP1 HMCN1 NOS3	2.11e-05	187	133	6	7876dcb4800c2e54874df3d933efb79307a64a97
ToppCell	facs-Heart-LA-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXS1 RDH5 ADRA2B PTPRK AOC3 TXNRD3	2.11e-05	187	133	6	a12f383b02b07af32cc53a154685df8dba8fbd3f
ToppCell	facs-Heart-LA-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXS1 RDH5 ADRA2B PTPRK AOC3 TXNRD3	2.11e-05	187	133	6	c40c152fa14e6afc9188549534b64ccbaded56b3
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-Pericytes-angiogenic_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXS1 ABRA SH2D3C ADRA2B HMCN2 AOC3	2.17e-05	188	133	6	0a5b93c131ce8514e996b0c2f39e0fc98636c122
ToppCell	RA-10._Endothelium_II\|World / Chamber and Cluster_Paper	HSPG2 ASAP1 HMCN1 TMEM108 OSMR NOS3	2.24e-05	189	133	6	75c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCell	IPF-Epithelial-Club\|IPF / Disease state, Lineage and Cell class	MFSD4A MAGI3 CAPN8 PTPRK TMEM108 OSMR	2.24e-05	189	133	6	f3fcef008ef252b29ac6d567fef27f9acf9cd70f
ToppCell	facs-Heart-RA-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXS1 RDH5 HSPA12A ADRA2B AOC3 TXNRD3	2.30e-05	190	133	6	bfbdf16d488359d7935a419c4c1823288f39c183
ToppCell	facs-Heart-RA-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXS1 RDH5 HSPA12A ADRA2B AOC3 TXNRD3	2.30e-05	190	133	6	eb1f8bb4d903b08e50c2dc173b06c0c79d8e316e
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ACACA AFF3 MAGI3 CAPN8 CSF3R PTPRK	2.37e-05	191	133	6	a0332a4ef629510fb313ec119195c44a3f704a80
ToppCell	IPF-Epithelial-Club\|World / Disease state, Lineage and Cell class	MAGI3 TEAD1 CAPN8 PTPRK TMEM108 OSMR	2.37e-05	191	133	6	3c88a6f1d74bb3b9173cd0ea3a63c6d9570e3954
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ACACA AFF3 MAGI3 TEAD1 CAPN8 PTPRK	2.37e-05	191	133	6	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	Control-Epithelial-Club\|Control / Disease state, Lineage and Cell class	MAGI3 TEAD1 CAPN8 PTPRK TMEM108 OSMR	2.44e-05	192	133	6	d84ed1ea4a03edaa18c804f75afb03bd7b1f0e16
ToppCell	Epithelial-alveolar_epithelial_cell_type_2\|World / Lineage, Cell type, age group and donor	ACACA AFF3 MAGI3 CAPN8 CSF3R PTPRK	2.44e-05	192	133	6	58c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCell	IPF-Epithelial-Club\|Epithelial / Disease state, Lineage and Cell class	ACACA MFSD4A MAGI3 CAPN8 HMCN1 TMEM108	2.44e-05	192	133	6	356e7a820b744a0ac87352a8d0e6e8d9fa9ed7d2
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH2D3C DAB2 DENND3 HMCN1 OSMR NOS3	2.44e-05	192	133	6	9ae05db5bfb8b9d3935c0328e6f2d489d2b1ebfd
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Endothelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH2D3C DAB2 DENND3 HMCN1 OSMR NOS3	2.44e-05	192	133	6	a116db7dec495e5a0ba9c7537057cd1e567d7885
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Endothelial-endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH2D3C DAB2 DENND3 HMCN1 OSMR NOS3	2.44e-05	192	133	6	66defad13bd8e79319741e43ddb056841710b1d7
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ACACA AFF3 MAGI3 CAPN8 CSF3R PTPRK	2.52e-05	193	133	6	fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-Pericytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXS1 NFASC USP2 ADRA2B NUTM2B AOC3	2.52e-05	193	133	6	7631bf3362b4fa061ffeab4879ab12c4708dc4c0
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXS1 NFASC USP2 ADRA2B NUTM2B AOC3	2.52e-05	193	133	6	8d15c63f2ae48d0a00d7ef5fdafa917ab8ad0571
ToppCell	RV-10._Endothelium_II\|World / Chamber and Cluster_Paper	HSPG2 ADD1 ASAP1 HMCN1 TMEM108 OSMR	2.52e-05	193	133	6	2531266bc57339d4e2b22a88817008e32b8c1598
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ACACA AFF3 MAGI3 CAPN8 CSF3R PTPRK	2.52e-05	193	133	6	f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell	LV-10._Endothelium_II\|LV / Chamber and Cluster_Paper	HSPG2 ASAP1 HMCN1 TMEM108 OSMR NOS3	2.59e-05	194	133	6	b6cc849fa08599bff9839ef382d190cc964e273e
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ACACA AFF3 MAGI3 TEAD1 CAPN8 PTPRK	2.59e-05	194	133	6	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	TCGA-Blood_and_Bone_Marrow-Primary_Tumor-Diffuse_large_B-cell_lymphoma-DLBCL-1\|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9	ARSJ TEAD1 PTPRK AOC3 OSMR NOS3	2.59e-05	194	133	6	eaeeb84576270cc3fc59002ba33bff9639bb0b02
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ACACA AFF3 MAGI3 CAPN8 PTPRK TMEM108	2.74e-05	196	133	6	ed76eeb37400ca154feae9b7ebaddb6c434f8b81
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HSPG2 ZBED2 MAGI3 TEAD1 DENND3 LRRN4	2.74e-05	196	133	6	eb68f7954e7c2f86d05e740e95b6e74805a6053f
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 SH2D3C PICALM ASAP1 HMCN1 NOS3	2.82e-05	197	133	6	c10dd1aaec01fb662eac83dfde90e3e426665d65
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 SH2D3C PICALM ASAP1 HMCN1 NOS3	2.82e-05	197	133	6	2844dbcd0a673ed81c99920aa45858651a00736d
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	NCOA2 ACACA AFF3 MAGI3 TEAD1 PTPRK	2.90e-05	198	133	6	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ACACA AFF3 MAGI3 CAPN8 CSF3R PTPRK	2.99e-05	199	133	6	725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ACACA AFF3 MAGI3 CAPN8 CSF3R PTPRK	2.99e-05	199	133	6	8587bd98de7767a575088afbea07a1feb4516b9b
ToppCell	Control_saline-Endothelial-Endothelial-Artery\|Control_saline / Treatment groups by lineage, cell group, cell type	ARSJ MAMLD1 PICALM HMCN1 AKR1B1 NOS3	3.07e-05	200	133	6	65b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCell	control-Neutrophil\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	EMILIN2 PICALM ASAP1 TNRC18 CSF3R GAA	3.07e-05	200	133	6	b5d197472799cc61d7497faed91ac2564ae4930a
ToppCell	Endothelial-G\|World / shred on cell class and cell subclass (v4)	DTX1 DAB2 MFSD4A FEV SLC24A1	3.56e-05	124	133	5	4b72809463f2986b7d1b7ab9de633ac4d7854a92
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D231\|Adult / Lineage, Cell type, age group and donor	NHLRC1 RBPJL NUTM2D MAGI3 CELSR3	4.79e-05	132	133	5	8d30b71776f5f6da55dc78e0c5cb27be460004e3
ToppCell	TCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma-5\|TCGA-Adrenal / Sample_Type by Project: Shred V9	CARMIL3 TNRC6C CELSR3 DQX1 FEV	5.15e-05	134	133	5	d4b175257c47916ed90cdb5c555c2b26530ce8d5
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet-plt_5\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MAMLD1 NFASC FOXD4L1 TMEM108 CFAP70	5.52e-05	136	133	5	27a41463e6f16deb5b1d4f17fefded9959038c07
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet-plt_5\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MAMLD1 NFASC FOXD4L1 TMEM108 CFAP70	5.52e-05	136	133	5	88b5c839d0446c6d6b7e81fc4d48f5e7e96eea11
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c2-CXCR4(low)\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	RDH5 TF CSF3R FYB1 SOD2	9.07e-05	151	133	5	b698ddc74565d47892c09c3f16d78038da2dd5e7
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CARMIL3 SMPDL3B CSF3R GIGYF2 FYB1	1.12e-04	158	133	5	b0508a600994090c6aafd8d779437190a33ad821
ToppCell	facs-Lung-EPCAM-3m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CARMIL3 SMPDL3B CSF3R GIGYF2 FYB1	1.12e-04	158	133	5	a816cc095452308d06f87b77467e2a8c6361fd2a
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-2_VIP_PPAPDC1A\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PCDHA1 SATL1 ADRA2B OSMR LINC01561	1.19e-04	160	133	5	7619c31815e41a42864b34ca825c96a2487a5da9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NRCAM NUTM2A MFSD4A GRM1 MYO3B	1.19e-04	160	133	5	03b88dc7ad41c6ae443cab7e77ec666340bf432e
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FOXS1 NFASC ADARB1 ADRA2B AOC3	1.30e-04	163	133	5	51dee6c21cbeca4e17d1cc386e203f0c403089e8
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	FOXS1 TDRKH NFASC CELSR3 AOC3	1.34e-04	164	133	5	d2218d50e0e2d19f919dcb460b3840687c082810
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DTX1 SH2D3C DAB2 MFSD4A SLC24A1	1.37e-04	165	133	5	50a8513d8d2630861499393a7f102b35366bad37
ToppCell	droplet-Spleen-nan-18m-Hematologic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMILIN2 SMPDL3B HMCN1 CSF3R FYB1	1.41e-04	166	133	5	e841e62cb20235d6233f78f4155fb8c0ffb1ef1b
ToppCell	droplet-Spleen-nan-18m-Hematologic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMILIN2 SMPDL3B HMCN1 CSF3R FYB1	1.41e-04	166	133	5	3ca3ddb663644f0e7f70f9b75833bb54cd9191d3
ToppCell	droplet-Spleen-nan-18m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMILIN2 SMPDL3B HMCN1 CSF3R FYB1	1.41e-04	166	133	5	f751cbd01d4978ded7755874ab60504f6291afd7
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS5 HSPA12A TMEM108 LRRN4 AHNAK2	1.45e-04	167	133	5	7abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS5 HSPA12A TMEM108 LRRN4 AHNAK2	1.45e-04	167	133	5	d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCell	Bronchial_Biopsy-Immune-Mast_cells\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	NRCAM ADARB1 TPSD1 TXNRD3 TMEM108	1.49e-04	168	133	5	45ccc0cb42d21f4853190e8e9ed9a54aefefe738
ToppCell	AT1-AT2_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	ARSJ ZBED2 MAGI3 TMEM108 AHNAK2	1.54e-04	169	133	5	815474855a70498a74e52f6583113c63b7267a0c
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-Pericytes-angiogenic_pericyte\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXS1 SH2D3C PCDHA3 ADRA2B AOC3	1.58e-04	170	133	5	d9ed257d0938442d0bb280e4c4b0c9b657511b46
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NRCAM TF CHRM5 HMCN1 PTPRQ	1.62e-04	171	133	5	121e63ca281ad765d76c2afb3b4d441329b47f81
ToppCell	Endothelial-Endothelial-G\|Endothelial / shred on cell class and cell subclass (v4)	DTX1 DAB2 MFSD4A CFAP70 SLC24A1	1.67e-04	172	133	5	644f8e42ee8d8996f6ae50cdf874559be55509fc
ToppCell	3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SH2D3C CHRM5 ASAP1 MYO3B OSMR	1.71e-04	173	133	5	b57d14e2c2368304cb903562d06ce8228f53857c
ToppCell	Basal_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	NCOA2 MAMLD1 RHOT2 HMCN1 TXNRD3	1.76e-04	174	133	5	a0060be3940043015dcc49a5157de5541aed24a1
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NRCAM MFSD4A GRM1 MYO3B FECH	1.81e-04	175	133	5	e5467dacf81f1f913b1719931cf1a7331434a7e7
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DTX1 COL24A1 HMCN1 PTPRQ CACNA1I	1.86e-04	176	133	5	c6484334187f64cd00cd35e77d8ae436556b4260
ToppCell	PND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DAB2 HSPA12A PTPRQ LRRN4 AHNAK2	1.86e-04	176	133	5	8e7f38de8bf68077e2138f4d06c1f55b0fd096cc
ToppCell	PND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DAB2 HSPA12A PTPRQ LRRN4 AHNAK2	1.86e-04	176	133	5	ed575330a08a6748ea4b28433292c8cfd157d444
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-early_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3TC2 CIART TPRN MFSD4A HMCN1	1.86e-04	176	133	5	7292e014b8f697f0c2e9f47c48333de95cb44a69
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-early_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3TC2 CIART TPRN MFSD4A HMCN1	1.86e-04	176	133	5	88ca2f83d8301633232735f39b0683efe49d0b86
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRM1 COL24A1 PTPRK GLCE TSHZ1	1.91e-04	177	133	5	921783ed0fe20294d2f384d9136924b679df01bb
ToppCell	ASK428-Epithelial-Secretory\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	SH2D3C EMILIN2 ARSG COL24A1 AKR1B1	1.91e-04	177	133	5	66074a288501c136b4e83b883db5f0d8269ee326
ToppCell	cellseq2-Mesenchymal-Myocytic-Myocytic_1-Pericyte\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NRCAM ADAMTS5 DENND3 ASAP1 AOC3	1.91e-04	177	133	5	68263456a3c93cd195b321b309ff59e156d732fe
ToppCell	cellseq2-Mesenchymal-Myocytic-Myocytic_1\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NRCAM ADAMTS5 DENND3 ASAP1 AOC3	1.91e-04	177	133	5	e415e448c37adc102d766235e9953dec32c021f1
ToppCell	metastatic_Brain-T/NK_cells-Exhausted_Tfh\|T/NK_cells / Location, Cell class and cell subclass	ZBED2 ASAP1 CAPN8 TNRC18 PTPRK	1.96e-04	178	133	5	9a3581a0158dfa5a1cc942f8c532afb5e38b272a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DTX1 MFSD4A GRM1 MYO3B FECH	2.06e-04	180	133	5	eee71184ebed2694d3e60f579a44b3cf7dd2cd35
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	ACACA GHDC MAGI3 CFAP70 AKR1B1	2.06e-04	180	133	5	12f3c4c4aa7fe03c0ef847bd4d4942c808015f5f
Disease	1,5 anhydroglucitol measurement	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1	2.25e-09	29	125	6	EFO_0008009
Disease	acute myeloid leukemia (is_implicated_in)	NCOA2 PICALM CSF3R MTHFR NOS3 SOD2	1.59e-06	84	125	6	DOID:9119 (is_implicated_in)
Disease	visceral adipose tissue measurement, body mass index	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1	1.95e-06	87	125	6	EFO_0004340, EFO_0004765
Disease	Abnormality of refraction	BRIP1 PCDHA9 CIART MAMLD1 RDH5 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1 DENND3 ASAP1	3.03e-05	673	125	12	HP_0000539
Disease	atherosclerosis (is_implicated_in)	ADD1 MTHFR NOS3	3.99e-05	16	125	3	DOID:1936 (is_implicated_in)
Disease	age at menopause	NCOA2 ACACA NRCAM TNRC18 CSF3R MTHFR LRRN4 SOD2	4.58e-05	302	125	8	EFO_0004704
Disease	Kuhnt-Junius degeneration (is_implicated_in)	MTHFR NOS3 SOD2	4.83e-05	17	125	3	DOID:10873 (is_implicated_in)
Disease	neutrophil count, basophil count	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1 CSF3R	4.94e-05	224	125	7	EFO_0004833, EFO_0005090
Disease	Acute Confusional Senile Dementia	TF PICALM MTHFR NOS3 SOD2	6.55e-05	99	125	5	C0546126
Disease	Alzheimer's Disease, Focal Onset	TF PICALM MTHFR NOS3 SOD2	6.55e-05	99	125	5	C0750900
Disease	Alzheimer Disease, Early Onset	TF PICALM MTHFR NOS3 SOD2	6.55e-05	99	125	5	C0750901
Disease	Presenile dementia	TF PICALM MTHFR NOS3 SOD2	6.55e-05	99	125	5	C0011265
Disease	Alzheimer Disease, Late Onset	TF PICALM MTHFR NOS3 SOD2	6.55e-05	99	125	5	C0494463
Disease	Familial Alzheimer Disease (FAD)	TF PICALM MTHFR NOS3 SOD2	6.87e-05	100	125	5	C0276496
Disease	Alzheimer's Disease	TF PICALM MTHFR NOS3 SOD2	7.20e-05	101	125	5	C0002395
Disease	response to cisplatin, platinum measurement	SPATA31E1 TEAD1 ADARB1 SPATA31C1	7.65e-05	53	125	4	EFO_0010154, GO_0072718
Disease	Myelocele	MTHFR SOD2	1.06e-04	4	125	2	C0086664
Disease	Meningomyelocele	MTHFR SOD2	1.06e-04	4	125	2	C0025312
Disease	Acquired Meningomyelocele	MTHFR SOD2	1.06e-04	4	125	2	C0751316
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	NHLRC1 TDRKH AFF3 NFASC RHOT2 TEAD1 KLHL29 HSPA12A ALMS1 PTPRK TNRC6A PRRC2B	1.58e-04	801	125	12	EFO_0003888, EFO_0007052, MONDO_0002491
Disease	hypertension (is_implicated_in)	ADD1 ADRA2B GLCE NOS3 SOD2	1.69e-04	121	125	5	DOID:10763 (is_implicated_in)
Disease	Endometrial Stromal Sarcoma	NUTM2A NUTM2B	1.77e-04	5	125	2	C0206630
Disease	Hypoplastic Left Heart Syndrome	PCDHA9 PCDHA13	1.77e-04	5	125	2	C0152101
Disease	thrombocytopenia (is_implicated_in)	BRIP1 MTHFR FYB1	2.02e-04	27	125	3	DOID:1588 (is_implicated_in)
Disease	lobe attachment	NHLRC1 GRM1 ASAP1 HMCN1 MYO3B FECH	2.60e-04	207	125	6	EFO_0007667
Disease	Clear cell sarcoma of kidney	NUTM2E NUTM2B	2.64e-04	6	125	2	C0334488
Disease	Paratuberculosis	TF AOC3	2.64e-04	6	125	2	C0030524
Disease	retinal vasculature measurement	HSPG2 AFF3 RDH5 TEAD1 DENND3 KLHL29 USP2 MYO3B OSMR	3.68e-04	517	125	9	EFO_0010554
Disease	alcoholic liver cirrhosis (is_implicated_in)	MTHFR SOD2	3.69e-04	7	125	2	DOID:14018 (is_implicated_in)
Disease	angle-closure glaucoma (is_implicated_in)	MTHFR NOS3	3.69e-04	7	125	2	DOID:13550 (is_implicated_in)
Disease	MASA syndrome (implicated_via_orthology)	NRCAM NFASC	3.69e-04	7	125	2	DOID:0060246 (implicated_via_orthology)
Disease	platelet component distribution width	SH3TC2 TLCD4 MAMLD1 NHLRC2 ASAP1 PRRC2C DOCK7 DLG3 FYB1 NOS3 GAA	3.78e-04	755	125	11	EFO_0007984
Disease	post-traumatic stress disorder symptom measurement	PCDHA8 PCDHA6 PCDHA3 PCDHA1	4.16e-04	82	125	4	EFO_0008535
Disease	bladder neck obstruction (biomarker_via_orthology)	NOS3 SOD2	6.29e-04	9	125	2	DOID:13948 (biomarker_via_orthology)
Disease	migraine (is_implicated_in)	MTHFR NOS3	6.29e-04	9	125	2	DOID:6364 (is_implicated_in)
Disease	non-syndromic X-linked intellectual disability (implicated_via_orthology)	FTSJ1 DLG3	6.29e-04	9	125	2	DOID:0050776 (implicated_via_orthology)
Disease	Nodular glomerulosclerosis	AOC3 NOS3 SOD2	7.03e-04	41	125	3	C0017667
Disease	neuroticism measurement, cognitive function measurement	PCDHA9 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1 KLHL29 PTPRK TNRC6A	7.05e-04	566	125	9	EFO_0007660, EFO_0008354
Disease	Essential hypertension	ADD1 NOS3	7.84e-04	10	125	2	cv:C0085580
Disease	Essential hypertension, genetic	ADD1 NOS3	7.84e-04	10	125	2	cv:CN305331
Disease	HYPERTENSION, ESSENTIAL	ADD1 NOS3	7.84e-04	10	125	2	145500
Disease	type 2 diabetes mellitus (is_implicated_in)	CAPN10 ADRA2B MTHFR AKR1B1 SOD2	8.26e-04	171	125	5	DOID:9352 (is_implicated_in)
Disease	myocardial infarction (is_implicated_in)	ADD1 ADRA2B MTHFR NOS3	8.47e-04	99	125	4	DOID:5844 (is_implicated_in)
Disease	Diabetic Nephropathy	AOC3 NOS3 SOD2	8.66e-04	44	125	3	C0011881
Disease	type 2 diabetes mellitus (implicated_via_orthology)	AFF3 CAPN10 ALMS1 AOC3	1.05e-03	105	125	4	DOID:9352 (implicated_via_orthology)
Disease	Cardiomyopathy, Dilated	ABRA ALMS1 SOD2	1.12e-03	48	125	3	C0007193
Disease	iron biomarker measurement	TF KLHL29 SOD2	1.12e-03	48	125	3	EFO_0004461
Disease	Male sterility	MTHFR NOS3 SOD2	1.12e-03	48	125	3	C0917731
Disease	Male infertility	MTHFR NOS3 SOD2	1.12e-03	48	125	3	C0021364
Disease	Subfertility, Male	MTHFR NOS3 SOD2	1.12e-03	48	125	3	C0848676
Disease	Essential Hypertension	ADD1 NOS3	1.14e-03	12	125	2	C0085580
Disease	developmental disorder of mental health (implicated_via_orthology)	GIGYF2 DLG3 PLXNB3	1.19e-03	49	125	3	DOID:0060037 (implicated_via_orthology)
Disease	Cardiomyopathy, Familial Idiopathic	ABRA ALMS1 SOD2	1.26e-03	50	125	3	C1449563
Disease	diabetic retinopathy (is_implicated_in)	MTHFR AKR1B1 NOS3	1.26e-03	50	125	3	DOID:8947 (is_implicated_in)
Disease	mean arterial pressure	SH3TC2 CWF19L2 NHLRC2 MAPKAPK5 METTL21A MTHFR TNRC6A NOS3	1.33e-03	499	125	8	EFO_0006340
Disease	Mental Retardation, X-Linked Nonsyndromic	FTSJ1 DLG3	1.35e-03	13	125	2	C3501611
Disease	intracranial aneurysm (biomarker_via_orthology)	AOC3 NOS3	1.35e-03	13	125	2	DOID:10941 (biomarker_via_orthology)
Disease	Skin Abnormalities	ZNF469 SOD2	1.35e-03	13	125	2	C0037268
Disease	diabetic neuropathy (is_implicated_in)	ADRA2B AKR1B1	1.57e-03	14	125	2	DOID:9743 (is_implicated_in)
Disease	anemia (is_implicated_in)	TF MTHFR	1.57e-03	14	125	2	DOID:2355 (is_implicated_in)
Disease	intelligence, self reported educational attainment	AFF3 CELSR3 HPS6 CACNA1I	1.57e-03	117	125	4	EFO_0004337, EFO_0004784
Disease	post-traumatic stress disorder	AFF3 PCDHA8 PCDHA6 PCDHA3 PCDHA1	1.73e-03	202	125	5	EFO_0001358
Disease	household income	AFF3 TEAD1 ADD1 HPS6 TNRC6A CACNA1I	1.92e-03	304	125	6	EFO_0009695
Disease	Diabetic Angiopathies	MTHFR NOS3	2.05e-03	16	125	2	C0011875
Disease	Microangiopathy, Diabetic	MTHFR NOS3	2.05e-03	16	125	2	C0025945
Disease	diabetic retinopathy (implicated_via_orthology)	AKR1B1 NOS3	2.05e-03	16	125	2	DOID:8947 (implicated_via_orthology)
Disease	sickle cell anemia (is_implicated_in)	MTHFR NOS3	2.05e-03	16	125	2	DOID:10923 (is_implicated_in)
Disease	hypertension (implicated_via_orthology)	ADD1 ADRA2B NOS3 SOD2	2.18e-03	128	125	4	DOID:10763 (implicated_via_orthology)
Disease	obesity (implicated_via_orthology)	ADARB1 CAPN8 ALMS1 AOC3 PLXNB3	2.27e-03	215	125	5	DOID:9970 (implicated_via_orthology)
Disease	vital capacity	HSPG2 SH3TC2 PCDHA9 AFF3 PCDHA13 PCDHA8 PCDHA6 PCDHA3 PCDHA1 TEAD1 ZNF263 HMCN1 SNAPC4	2.29e-03	1236	125	13	EFO_0004312
Disease	Necrotizing Enterocolitis	NOS3 SOD2	2.32e-03	17	125	2	C0520459
Disease	1-Methylhistidine measurement	NCOA2 ALMS1	2.32e-03	17	125	2	EFO_0021543
Disease	Night blindness, congenital stationary	RDH5 SLC24A1	2.32e-03	17	125	2	C0339535
Disease	Vascular Diseases	MTHFR SOD2	2.32e-03	17	125	2	C0042373
Disease	Alzheimer disease, psychotic symptoms	TNRC6C PICALM	2.32e-03	17	125	2	EFO_0005940, MONDO_0004975
Disease	essential hypertension (is_implicated_in)	ADD1 NOS3	2.61e-03	18	125	2	DOID:10825 (is_implicated_in)
Disease	non-alcoholic fatty liver disease (is_implicated_in)	MTHFR SOD2	2.61e-03	18	125	2	DOID:0080208 (is_implicated_in)
Disease	myocardial infarction (implicated_via_orthology)	DAB2 NOS3 SOD2	2.80e-03	66	125	3	DOID:5844 (implicated_via_orthology)
Disease	cardiomyopathy (is_implicated_in)	NOS3 SOD2	2.90e-03	19	125	2	DOID:0050700 (is_implicated_in)
Disease	severe acute respiratory syndrome, COVID-19	NCOA2 MAMLD1 NFASC PCDHA6 COL24A1 HSPA12A MYO3B	3.01e-03	447	125	7	EFO_0000694, MONDO_0100096
Disease	creatinine measurement	DMGDH BRIP1 DAB2 CELSR3 ALMS1 PRRC2C DOCK7 GIGYF2 PNPLA7 CFAP70 AKR1B1	3.42e-03	995	125	11	EFO_0004518
Disease	myocardial infarction	TDRKH BRIP1 MAGI3 GIGYF2 NOS3 GAA	3.84e-03	350	125	6	EFO_0000612
Disease	mean platelet volume	NHLRC1 AFF3 NFASC PICALM ASAP1 KLHL29 MTHFR TNRC6A DOCK7 DLG3 NOS3	4.12e-03	1020	125	11	EFO_0004584

Protein segments in the cluster

Peptide	Gene	Start	Entry
AQAPSPWGASGKSTG	AFF3	1101	P51826
QSALSPAGGSGPQTW	ADAMTS5	241	Q9UNA0
PSWGPLSPAVQKGSG	FEV	31	Q99581
TGGPPEADGLVQWKA	GVINP1	436	Q7Z2Y8
VSAVTGPGNQKTWIP	ALMS1	1171	Q8TCU4
QTAGIPTLPWSGSGL	ACACA	251	Q13085
PPSWAALPNSGQGQK	ADRA2B	271	P18089
RQGGSPAKQTTWEGG	ARSG	326	Q96EG1
ISGVEGVPLSTQWGP	GLCE	191	O94923
KNTTPGAALPAGEWG	CAPN10	501	Q9HC96
KDLGPGSPQTQGIIW	CAPN8	61	A6NHC0
KQVWVGSRGLGQGTP	DENND3	1131	A2RUS2
PPGGSKETWGLQETL	CCER1	236	Q8TC90
LGLGTWKSPPGQVTE	AKR1B1	16	P15121
IPDNGTGGSWSLKSP	AOC3	291	Q16853
LSGPGWRVKPGQDQA	RBPJL	96	Q9UBG7
PPVGAGVNSNSWTFK	PCDHA9	856	Q9Y5H5
GGFSLSWKPQPGDVI	OSMR	541	Q99650
TLEWTGGPGGQLPAK	HSPG2	1896	P98160
PPVGAGVNSNSWTFK	PCDHA6	856	Q9UN73
SEVAWGPQKGQAGLT	MRNIP	171	Q6NTE8
LGGVTVTLPQAGPWN	DAB2	501	P98082
PNINGKPSSDPIVGW	MTHFR	486	P42898
PPVGAGVNSNSWTFK	PCDHA8	856	Q9Y5H6
PPVGAGVNSNSWTFK	PCDHA3	856	Q9Y5H8
PWKVPSGNKVTGTIG	MAGI3	1461	Q5TCQ9
SINWTQKLGAGISGP	MAPKAPK5	21	Q8IW41
WGLVGKSNPKTPQGT	SLC24A1	296	O60721
WSNQTFPGLTPKDGA	MFSD4A	201	Q8N468
TWKPLNGFESNGPGL	NRCAM	766	Q92823
PNITWDKDGQPVSGA	HMCN2	4061	Q8NDA2
QPTAGGSNWPLRGSK	ARSJ	331	Q5FYB0
WKTTLPGVVNGANNP	SMPDL3B	306	Q92485
GPGPDQEGSTQAWQK	CARMIL3	1176	Q8ND23
SFGKCPGGRNPWTGV	PCYT2	176	Q99447
SLSPRWGPQAGGTQL	PLXNB3	931	Q9ULL4
RPSGNSSSGGKIWQG	PIN1P1	36	O15428
TDQSGRVWPVNTPGK	CWF19L2	551	Q2TBE0
QQQIPGKPGTFTWQG	CSPP1	1236	Q1MSJ5
APSKLTVGGPWGQSQ	FYB1	316	O15117
WPGNTLGQVGTPGTK	GHDC	166	Q8N2G8
RWEGGDPGVSNQKTP	HSPA12A	86	O43301
WPQGSQGKTLRGSFS	GPR180	16	Q86V85
QPGKAPNFSVNWTVG	ADARB1	631	P78563
KSQSWPVGASSGQPC	DTX1	186	Q86Y01
EPGSGKSTQIPQWCA	DQX1	71	Q8TE96
LGLPTEGSKWDLGNP	PNPLA7	711	Q6ZV29
GGAKGEQQPISSPWD	NHLRC2	326	Q8NBF2
SGVGVGWIRQPPGKA	IGHV2-5	51	P01817
ATGTPPPQINWLKNG	HMCN1	3366	Q96RW7
QPDPWKGSAAKGTGI	NOS3	476	P29474
IATQGPLPGTVGDFW	PTPRQ	2106	Q9UMZ3
PPVGAGVNSNSWTFK	PCDHA1	856	Q9Y5I3
PPVGAGVNSNSWTFK	PCDHA13	856	Q9Y5I0
VWVGTIGSGPKGRNL	BRIP1	646	Q9BX63
KELTWGQNLGSFSPG	METTL21A	121	Q8WXB1
GSPIPTLRWFKNGQG	NFASC	456	O94856
GSLNTSGAGPKSWQV	BABAM1	61	Q9NWV8
RSNSWVNTGGPKAAP	DOCK7	926	Q96N67
IGNSVWGSINTGPPN	GIGYF2	1041	Q6Y7W6
GKRESSLGPWGITNG	CFAP70	791	Q5T0N1
GTGTLPKIALQGSWA	CACNA1I	1981	Q9P0X4
NKGAVPWGNDGGPSS	ASAP1	851	Q9ULH1
PGKSTPKLNGSGPSW	DLG3	91	Q92796
IEWGLGPPSASNSNK	CSF3R	461	Q99062
ETGQPLIGKVWPGST	GAA	471	P10253
GSATKQQGPTPSWSG	MAMLD1	316	Q13495
QDSWVTNGVPPGFGK	DMGDH	321	Q9UI17
SLGPQPWEEGKGLAS	FOXD4L1	301	Q9NU39
KEPWVAGGFPVQGGS	FOXS1	296	O43638
GSNVTGLKPGDWVIP	MECR	116	Q9BV79
NWSKTEEAFPGGPLG	ELP5	91	Q8TE02
TGTAQPSWGVDPKEG	EMILIN2	161	Q9BXX0
IGGGSPIKIWTSKQG	FECH	126	P22830
VVSPTVPGGLSDGQW	CELSR3	1586	Q9NYQ7
KSVSWSEPGGGQVPK	GRM1	891	Q13255
VGTLQEAPVGPWGSA	HPS6	301	Q86YV9
LSIPWGIKQAGFTTG	SLC38A9	136	Q8NBW4
IGGQFSLPWGVETTP	NHLRC1	211	Q6VVB1
PLFRVTQQGPWGSSG	LRRN4	26	Q8WUT4
KGPLANPIWNVTGFT	PTPRK	131	Q15262
QSLTWGLGGPSQSQK	NUTM2A	846	Q8IVF1
QSLTWGLGGPSQSQK	NUTM2B	846	A6NNL0
ASGLLSPEKWGPQGT	NUTM2D	711	Q5VT03
SGEQSLTWGLGGPSQ	NUTM2D	771	Q5VT03
QSLTWGLGGPSQSQK	NUTM2E	846	B1AL46
SQPQWGSGVPRAGKQ	RTEL1	1041	Q9NZ71
WGPISLNNGLVPVGK	RTP5	306	Q14D33
PGGQKIDAVAWNTTP	TARS2	66	Q9BW92
TSEPKGNSWAPNGLS	RNF207	591	Q6ZRF8
TGIVGGQEAPRSKWP	TPSD1	36	Q9BZJ3
TGWGDSNNKAPSGPG	TNRC6C	521	Q9HCJ0
SNNKAPSGPGVWGDS	TNRC6C	526	Q9HCJ0
PGTNWGETLKPGPQQ	TNRC6C	651	Q9HCJ0
KQTGTGWIGGPVPVK	TNRC6C	686	Q9HCJ0
GWIGGPVPVKQKDSS	TNRC6C	691	Q9HCJ0
LVDNGTAAWGKPPSS	TNRC6C	826	Q9HCJ0
KWIPLVNGGTTQGPR	RHOT2	96	Q8IXI1
ETFPGTQGQKGIQPW	GPRASP2	181	Q96D09
TQGQKGIQPWFGPGE	GPRASP2	186	Q96D09
PAPKSWASNKQGGQG	PRRC2C	116	Q9Y520
MKQPGTWQLGRSQPG	SATL1	316	Q86VE3
QNTTKLLGFPSPGWG	SH3TC2	716	Q8TF17
LWKGGDSPGQQEPGS	SPATA31E1	1171	Q6ZUB1
GSLKAPTAGQEGRWP	SPATA31C1	761	P0DKV0
NAGVAGIIGPTPWLT	RDH5	111	Q92781
VPGGTTWAGSSQQKP	SPAG4	66	Q9NPE6
PFASQGANPWSKLSG	SMCR8	36	Q8TEV9
SIRQAQEPTGWLPGG	ABRA	41	Q8N0Z2
TGKPSQATGPSANWA	CHRM5	281	P08912
TWPGTPGSVSGRQLQ	AHNAK2	11	Q8IVF2
GEGTGSPPKWQIGEQ	ADD1	361	P35611
WFPQIAAQKSSLGGG	CIART	191	Q8N365
GPKPDSSWEAGSQGN	LINC01561	36	Q8N1V8
TQTSGPGLPIGFKGW	COL24A1	1631	Q17RW2
LPKSIVNGGSWSGEP	NCOA2	176	Q15596
QPGEKKLTGGSNWQP	PICALM	566	Q13492
KLTGGSNWQPKVAPT	PICALM	571	Q13492
DPGAGGWQEPKSLLS	TNRC18	2486	O15417
SRGPGVNVGTTALWK	ZBED2	86	Q9BTP6
TVPQNTGGKNPDPWA	TF	556	P02787
TEPGGAGEPALWKNT	TDRKH	226	Q9Y2W6
QENTNSVPGGPKSWA	PRRC2B	131	Q5JSZ5
SVPGGPKSWAQLNGK	PRRC2B	136	Q5JSZ5
TKADPLWGGPSLANV	TLCD4	76	Q96MV1
FWTNLSPNGGGEPKG	SOD2	101	P04179
DVVNIWAGQGKASPP	WDR46	421	O15213
PTGQKGASARGFWGP	ZNF469	2716	Q96JG9
APGSWSQVLSQKIGG	FTSJ1	51	Q9UET6
SPPGSGQWKPKVESG	TPRN	241	Q4KMQ1
DFVVPSPQGTSWGLG	TXNRD3	186	Q86VQ6
NGAPEGDWGKTFTVP	SH2D3C	531	Q8N5H7
GAPAAAKPGTSGSWQ	SNAPC4	956	Q5SXM2
FWPGMIQTGQPGSSQ	TEAD1	156	P28347
LWETGKGQAPGPSRS	USP2	236	O75604
GPTPHQGGWKQVEQS	WASH6P	26	Q9NQA3
NGTSAWGKPIDSGPS	TNRC6A	1076	Q8NDV7
TAISKAQNGAPSWGG	TSHZ1	561	Q6ZSZ6
NRLVPAGTWKPGTAG	TMEM108	431	Q6UXF1
PGTQVGQGGKLWDPS	ZNF263	266	O14978
NPGTGPWVTTVAAGN	KLHL29	141	Q96CT2
SLWGAPQKPGSENGL	MYO3B	1236	Q8WXR4