Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionryanodine-sensitive calcium-release channel activity

RYR2 RYR3

1.12e-044872GO:0005219
GeneOntologyCellularComponenthost cell part

GBP6 GBP4

2.60e-046882GO:0033643
GeneOntologyCellularComponenthost intracellular part

GBP6 GBP4

2.60e-046882GO:0033646
GeneOntologyCellularComponenthost cell cytoplasm part

GBP6 GBP4

2.60e-046882GO:0033655
GeneOntologyCellularComponentsymbiont-containing vacuole

GBP6 GBP4

2.60e-046882GO:0020003
GeneOntologyCellularComponentsymbiont-containing vacuole membrane

GBP6 GBP4

2.60e-046882GO:0020005
GeneOntologyCellularComponenthost intracellular region

GBP6 GBP4

2.60e-046882GO:0043656
GeneOntologyCellularComponenthost cell cytoplasm

GBP6 GBP4

2.60e-046882GO:0030430
GeneOntologyCellularComponentcyclin/CDK positive transcription elongation factor complex

CCNT1 CCNT2

6.19e-049882GO:0008024
GeneOntologyCellularComponenttransferase complex

CCNT1 CCNT2 DCAF4L2 JADE3 JADE2 FBXO42 UGT3A1 ANKIB1 PRKDC JADE1 PIGV KDM6A

6.95e-049638812GO:1990234
GeneOntologyCellularComponentsemaphorin receptor complex

PLXNA4 PLXNA2

1.33e-0313882GO:0002116
GeneOntologyCellularComponenthost cellular component

GBP6 GBP4

1.78e-0315882GO:0018995
Domain-

SEH1L AHI1 DCAF4L2 MED16 PLXNA4 WDR18 WSB2 HERC1 PLXNA2 WDFY1 HIRA

3.23e-0733385112.130.10.10
DomainWD40/YVTN_repeat-like_dom

SEH1L AHI1 DCAF4L2 MED16 PLXNA4 WDR18 WSB2 HERC1 PLXNA2 WDFY1 HIRA

3.43e-073358511IPR015943
DomainWD40_repeat

SEH1L AHI1 DCAF4L2 MED16 WDR18 WSB2 HERC2 HERC1 WDFY1 HIRA

4.36e-072728510IPR001680
DomainWD_REPEATS_1

SEH1L AHI1 DCAF4L2 MED16 WDR18 WSB2 HERC2 HERC1 WDFY1 HIRA

5.32e-072788510PS00678
DomainWD_REPEATS_2

SEH1L AHI1 DCAF4L2 MED16 WDR18 WSB2 HERC2 HERC1 WDFY1 HIRA

5.50e-072798510PS50082
DomainWD_REPEATS_REGION

SEH1L AHI1 DCAF4L2 MED16 WDR18 WSB2 HERC2 HERC1 WDFY1 HIRA

5.50e-072798510PS50294
DomainWD40

SEH1L AHI1 DCAF4L2 MED16 WDR18 WSB2 HERC1 WDFY1 HIRA

2.71e-06259859PF00400
DomainWD40

SEH1L AHI1 DCAF4L2 MED16 WDR18 WSB2 HERC1 WDFY1 HIRA

3.59e-06268859SM00320
DomainEPL1

JADE3 JADE2 JADE1

5.01e-068853PF10513
DomainEnhancer_polycomb-like_N

JADE3 JADE2 JADE1

5.01e-068853IPR019542
DomainWD40_repeat_dom

SEH1L AHI1 DCAF4L2 MED16 WDR18 WSB2 HERC1 WDFY1 HIRA

8.23e-06297859IPR017986
DomainRyanrecept_TM4-6

RYR2 RYR3

6.12e-053852IPR009460
DomainRyR

RYR2 RYR3

6.12e-053852PF02026
DomainRyanodine_rcpt

RYR2 RYR3

6.12e-053852IPR003032
DomainRR_TM4-6

RYR2 RYR3

6.12e-053852PF06459
DomainRyan_recept

RYR2 RYR3

6.12e-053852IPR013333
Domain-

KLHL30 ATRNL1 FBXO42 KBTBD2

6.67e-05488542.120.10.80
DomainKelch-typ_b-propeller

KLHL30 ATRNL1 FBXO42 KBTBD2

1.14e-0455854IPR015915
DomainEPHD

JADE3 JADE2 JADE1

1.32e-0422853PS51805
DomainClaudin_CS

CLDN24 CLDN22 CLDN10

1.32e-0422853IPR017974
DomainCLAUDIN

CLDN24 CLDN22 CLDN10

1.32e-0422853PS01346
DomainChemokine-like_2FAM19A2

TAFA4 TAFA2

2.03e-045852PD298472
DomainChemokine-like_FAM19A2

TAFA4 TAFA2

2.03e-045852IPR020350
DomainTAFA

TAFA4 TAFA2

2.03e-045852PF12020
DomainClaudin

CLDN24 CLDN22 CLDN10

2.74e-0428853IPR006187
DomainKelch_1

KLHL30 ATRNL1 FBXO42 KBTBD2

2.91e-0470854PF01344
DomainKelch_1

KLHL30 ATRNL1 FBXO42 KBTBD2

2.91e-0470854IPR006652
DomainRIH_assoc

RYR2 RYR3

3.03e-046852PF08454
DomainRIH_assoc-dom

RYR2 RYR3

3.03e-046852IPR013662
DomainRIH_dom

RYR2 RYR3

3.03e-046852IPR000699
DomainIns145_P3_rcpt

RYR2 RYR3

3.03e-046852IPR014821
DomainRyanodine_recept-rel

RYR2 RYR3

3.03e-046852IPR015925
Domain-

RYR2 RYR3

3.03e-0468521.25.10.30
DomainRYDR_ITPR

RYR2 RYR3

3.03e-046852PF01365
DomainIns145_P3_rec

RYR2 RYR3

3.03e-046852PF08709
DomainPSI

ATRNL1 PLXNA4 PLXNA2

4.10e-0432853PF01437
DomainPlexin_repeat

ATRNL1 PLXNA4 PLXNA2

4.10e-0432853IPR002165
DomainZnf_FYVE_PHD

JADE3 JADE2 ANKIB1 JADE1 WDFY1

5.58e-04147855IPR011011
DomainCyclin_L/T

CCNT1 CCNT2

5.63e-048852IPR015429
DomainG-protein_beta_WD-40_rep

SEH1L WDR18 WSB2 WDFY1

6.11e-0485854IPR020472
DomainPlexin_cytopl

PLXNA4 PLXNA2

7.22e-049852PF08337
DomainPlexin_cytoplasmic_RasGAP_dom

PLXNA4 PLXNA2

7.22e-049852IPR013548
DomainPlexin

PLXNA4 PLXNA2

7.22e-049852IPR031148
DomainPMP22_Claudin

CLDN24 CLDN22 CLDN10

7.96e-0440853PF00822
DomainMIR

RYR2 RYR3

9.00e-0410852PS50919
DomainMIR

RYR2 RYR3

9.00e-0410852PF02815
DomainMIR

RYR2 RYR3

9.00e-0410852SM00472
DomainMIR_motif

RYR2 RYR3

9.00e-0410852IPR016093
DomainGBP_C

GBP6 GBP4

9.00e-0410852PF02841
DomainWD40_repeat_CS

WDR18 WSB2 HERC1 WDFY1 HIRA

9.15e-04164855IPR019775
DomainPSI

ATRNL1 PLXNA4 PLXNA2

1.05e-0344853IPR016201
DomainG_GB1_RHD3_dom

GBP6 GBP4

1.10e-0311852IPR030386
DomainGuanylate-bd_C

GBP6 GBP4

1.10e-0311852IPR003191
DomainGBP

GBP6 GBP4

1.10e-0311852PF02263
DomainGuanylate-bd_N

GBP6 GBP4

1.10e-0311852IPR015894
DomainG_GB1_RHD3

GBP6 GBP4

1.10e-0311852PS51715
DomainPMP22/EMP/MP20/Claudin

CLDN24 CLDN22 CLDN10

1.12e-0345853IPR004031
DomainPSI

ATRNL1 PLXNA4 PLXNA2

1.20e-0346853SM00423
DomainKelch_2

ATRNL1 FBXO42

1.55e-0313852IPR011498
DomainKelch_2

ATRNL1 FBXO42

1.55e-0313852PF07646
DomainZinc_finger_PHD-type_CS

JADE3 JADE2 JADE1

3.24e-0365853IPR019786
DomainRCC1

HERC2 HERC1

3.69e-0320852PF00415
DomainRCC1_1

HERC2 HERC1

4.06e-0321852PS00625
DomainRCC1_2

HERC2 HERC1

4.06e-0321852PS00626
DomainRCC1_3

HERC2 HERC1

4.06e-0321852PS50012
Domain-

JADE3 JADE2 ANKIB1 BIRC7 JADE1 WDFY1 RNF215

4.36e-034498573.30.40.10
DomainReg_chr_condens

HERC2 HERC1

4.46e-0322852IPR000408
Domain-

HERC2 HERC1

4.46e-03228522.130.10.30
Pubmed

Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development.

JADE3 JADE2 JADE1

1.73e-08391314612400
Pubmed

Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.

CHRM3 RYR2 RYR3

3.45e-07691319549818
Pubmed

In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters.

GBP6 GBP4 ABCG2

9.61e-07891316689661
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

SLC6A2 SEPTIN8 AHI1 GBP4 ATRNL1 PGAP1 POP1 ANKRD49 TFIP11 JADE1 HERC1 WDFY1 RNF215

4.93e-061084911311544199
Pubmed

Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease.

RYR2 RYR3

6.77e-06291221531043
Pubmed

Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells.

RYR2 RYR3

6.77e-06291216678258
Pubmed

The SCID mouse: an experimental model for endometriosis.

MKKS PRKDC

6.77e-06291210601104
Pubmed

L-fucose reduces gut inflammation due to T-regulatory response in Muc2 null mice.

PRKDC MUC2

6.77e-06291236584066
Pubmed

Tripeptidyl peptidase II regulates sperm function by modulating intracellular Ca(2+) stores via the ryanodine receptor.

TPP2 RYR3

6.77e-06291223818952
Pubmed

Tissue-specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA.

RYR2 RYR3

6.77e-0629128898078
Pubmed

The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors.

RYR2 RYR3

6.77e-06291214550562
Pubmed

Decreased expression of ryanodine receptors alters calcium-induced calcium release mechanism in mdx duodenal myocytes.

RYR2 RYR3

6.77e-06291214985349
Pubmed

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

DOCK2 CCNT1 CCNT2 TMPRSS13 TFIP11 RYR2

1.37e-0519791620811636
Pubmed

Biology of claudins.

CLDN24 CLDN22 CLDN10

1.63e-051991318480174
Pubmed

Structural Basis for Plexin Activation and Regulation.

PLXNA4 PLXNA2

2.03e-05391227397516
Pubmed

Interactions between plexin-A2, plexin-A4, and semaphorin 6A control lamina-restricted projection of hippocampal mossy fibers.

PLXNA4 PLXNA2

2.03e-05391217296555
Pubmed

Regulation of P-TEFb elongation complex activity by CDK9 acetylation.

CCNT1 CCNT2

2.03e-05391217452463
Pubmed

Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.

RYR2 RYR3

2.03e-05391218403125
Pubmed

Host platelets and, in part, neutrophils mediate lung accumulation of transfused UVB-irradiated human platelets in a mouse model of acute lung injury.

PRKDC ITGA2B

2.03e-05391223028636
Pubmed

Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.

RYR2 RYR3

2.03e-05391218434746
Pubmed

Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin.

RYR2 RYR3

2.03e-05391229730765
Pubmed

Cyclin T2 is essential for mouse embryogenesis.

CCNT1 CCNT2

2.03e-05391219364821
Pubmed

Role of the human and murine cyclin T proteins in regulating HIV-1 tat-activation.

CCNT1 CCNT2

2.03e-05391210329126
Pubmed

SPRY domains in ryanodine receptors (Ca(2+)-release channels).

RYR2 RYR3

2.03e-0539129204703
Pubmed

Identification of multiple cyclin subunits of human P-TEFb.

CCNT1 CCNT2

2.03e-0539129499409
Pubmed

Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells.

PLXNA4 PLXNA2

2.03e-05391218625214
Pubmed

The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.

RYR2 RYR3

2.03e-0539127876312
Pubmed

Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.

RYR2 RYR3

2.03e-05391221881589
Pubmed

Interactions between Tat and TAR and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins T2a or T2b.

CCNT1 CCNT2

2.03e-05391210049833
Pubmed

Role of transmembrane semaphorin Sema6A in oligodendrocyte differentiation and myelination.

PLXNA4 PLXNA2

2.03e-05391222777942
Pubmed

Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).

RYR2 RYR3

2.03e-05391212213830
Pubmed

Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.

RYR2 RYR3

2.03e-0539129242641
Pubmed

Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.

RYR2 RYR3

2.03e-05391222948152
Pubmed

Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.

RYR2 RYR3

2.03e-05391210788707
Pubmed

RYR2 proteins contribute to the formation of Ca(2+) sparks in smooth muscle.

RYR2 RYR3

2.03e-05391215024040
Pubmed

Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.

RYR2 RYR3

2.03e-05391225239916
Pubmed

Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.

RYR2 RYR3

2.03e-0539127621815
Pubmed

Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes.

CCNT1 CCNT2

2.03e-05391210364329
Pubmed

A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.

RYR2 RYR3

2.03e-05391218643873
Pubmed

Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).

RYR2 RYR3

2.03e-05391211159936
Pubmed

Molecular identification of the ryanodine receptor pore-forming segment.

RYR2 RYR3

2.03e-05391210473538
Pubmed

The CDK9-associated cyclins T1 and T2 exert opposite effects on HIV-1 Tat activity.

CCNT1 CCNT2

2.03e-05391210465067
Pubmed

Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.

RYR2 RYR3

2.03e-0539127959768
Pubmed

The organization of proteins in the human red blood cell membrane. A review.

RYR2 RYR3

2.03e-0539124600883
Pubmed

Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.

RYR2 RYR3

2.03e-0539127635066
Pubmed

Multifunctional strands in tight junctions.

CLDN24 CLDN22 CLDN10

2.23e-052191311283726
Pubmed

Claudin-based barrier in simple and stratified cellular sheets.

CLDN24 CLDN22 CLDN10

2.23e-052191312231346
Pubmed

Tight junction proteins.

CLDN24 CLDN22 CLDN10

2.23e-052191312475568
Pubmed

KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation.

JADE3 JADE2 JADE1

2.23e-052191327270040
Pubmed

Tight junctions of the blood-brain barrier.

CLDN24 CLDN22 CLDN10

2.23e-052191310690502
Pubmed

The roles of claudin superfamily proteins in paracellular transport.

CLDN24 CLDN22 CLDN10

2.23e-052191311247307
Pubmed

Structure and function of claudins.

CLDN24 CLDN22 CLDN10

2.95e-052391318036336
Pubmed

The claudins.

CLDN24 CLDN22 CLDN10

2.95e-052391319706201
Pubmed

A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.

RYR2 RYR3

4.05e-05491218206662
Pubmed

The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.

CCNT1 CCNT2

4.05e-05491218566585
Pubmed

Tight junction-based epithelial microenvironment and cell proliferation.

CLDN24 CLDN22

4.05e-05491219029935
Pubmed

Chromosome assignment of four plexin A genes (Plxna1, Plxna2, Plxna3, Plxna4) in mouse, rat, Syrian hamster and Chinese hamster.

PLXNA4 PLXNA2

4.05e-05491211306810
Pubmed

Reversal of autoimmunity by boosting memory-like autoregulatory T cells.

PRKDC G6PC2

4.05e-05491220381385
Pubmed

Ryanodine receptor calcium release channels: lessons from structure-function studies.

RYR2 RYR3

4.05e-05491223413940
Pubmed

PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.

PLXNA4 PLXNA2

4.05e-05491225518740
Pubmed

Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription.

CCNT1 CCNT2

4.05e-05491217289077
Pubmed

Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.

RYR2 RYR3

4.05e-0549129384575
Pubmed

The Cdk9 and cyclin T subunits of TAK/P-TEFb localize to splicing factor-rich nuclear speckle regions.

CCNT1 CCNT2

4.05e-05491211282025
Pubmed

Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.

RYR2 RYR3

4.05e-0549129607712
Pubmed

Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb.

CCNT1 CCNT2

4.05e-05491215563843
Pubmed

Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.

RYR2 RYR3

4.05e-05491223482488
Pubmed

Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation.

CLDN24 CLDN22 CLDN10

4.31e-052691322275141
Pubmed

Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex.

TTLL12 SEH1L PRKDC

6.68e-053091316449650
Pubmed

TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain.

TAFA4 TAFA2

6.74e-05591215028294
Pubmed

Guidance-cue control of horizontal cell morphology, lamination, and synapse formation in the mammalian outer retina.

PLXNA4 PLXNA2

6.74e-05591222593055
Pubmed

Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases.

RYR2 RYR3

6.74e-05591233060591
Pubmed

Expanding antigen-specific regulatory networks to treat autoimmunity.

PRKDC G6PC2

6.74e-05591226886799
Pubmed

Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.

RYR2 RYR3

6.74e-05591223918386
Pubmed

Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA.

CCNT1 CCNT2

6.74e-05591219883659
Pubmed

Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.

RYR2 RYR3

6.74e-05591219011160
Pubmed

Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

DOCK2 SEPTIN8 JADE3 JADE2

6.88e-05839149039502
Pubmed

Semaphorin-Plexin signaling influences early ventral telencephalic development and thalamocortical axon guidance.

PLXNA4 PLXNA2

1.01e-04691228438183
Pubmed

Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.

RYR2 RYR3

1.01e-04691226025922
Pubmed

Roles of semaphorin-6B and plexin-A2 in lamina-restricted projection of hippocampal mossy fibers.

PLXNA4 PLXNA2

1.01e-04691220484647
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

RYR2 RYR3

1.01e-04691223463619
Pubmed

FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.

RYR2 RYR3

1.01e-04691214592808
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

RYR2 RYR3

1.01e-04691220519450
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

RYR2 RYR3

1.01e-04691225966694
Pubmed

HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.

RYR2 RYR3

1.01e-04691219009018
Pubmed

Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.

CCNT1 CCNT2

1.01e-04691224515107
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

RYR2 RYR3

1.01e-04691216844763
Pubmed

7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes.

CCNT1 CCNT2

1.01e-04691211713533
Pubmed

AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells.

CCNT1 CCNT2

1.01e-04691217938200
Pubmed

Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.

CCNT1 POP1 ZNF629 PRKDC PRPF8

1.20e-0418291532239614
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

TTLL12 JADE2 ATRNL1 ANKRD49 TFIP11 RIPK4 PRKDC KIFC3 HERC2 PRPF8 KDM6A RYR3

1.31e-041285911235914814
Pubmed

DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.

CCNT1 DCAF4L2 MED16 WDFY1

1.37e-049991434161765
Pubmed

MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner.

CCNT1 CCNT2

1.41e-04791212832472
Pubmed

Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points.

PLXNA4 PLXNA2

1.41e-04791219063725
Pubmed

Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice.

PLXNA4 PLXNA2

1.41e-04791219655386
Pubmed

The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities.

HERC2 HERC1

1.41e-0479129949213
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

RYR2 RYR3

1.41e-04791211860456
Pubmed

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor.

CCNT1 CCNT2

1.41e-04791215201869
Pubmed

Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.

RYR2 RYR3

1.41e-04791220962236
Pubmed

WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.

SEH1L HERC1 HIRA

1.60e-044091329078390
Pubmed

ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.

JADE3 JADE2 JADE1

1.85e-044291316387653
GeneFamilyWD repeat domain containing

SEH1L AHI1 DCAF4L2 MED16 WDR18 WSB2 HERC1 WDFY1 HIRA

2.94e-07262639362
GeneFamilyRyanodine receptors|Protein phosphatase 1 regulatory subunits

RYR2 RYR3

3.58e-053632287
GeneFamilyClaudins

CLDN24 CLDN22 CLDN10

6.79e-0523633488
GeneFamilyCyclins|P-TEFb complex

CCNT1 CCNT2

7.14e-0546321281
GeneFamilyPlexins

PLXNA4 PLXNA2

4.23e-049632683
GeneFamilyPHD finger proteins

JADE3 JADE2 JADE1

3.82e-039063388
GeneFamilyCyclins

CCNT1 CCNT2

4.26e-0328632473
ToppCellPCW_13-14-Endothelial-Endothelial_immature-endo_immature_arterial1_(12)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DPEP1 GBP4 FUT9 THSD7B TM4SF1 CHRM3

2.92e-0619491632ba2cf9b8726bc3c6e9dc24b54d22ff188bb12b
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

AHI1 ATRNL1 HERC1 CSMD3 CHRM3 RYR2

3.29e-061989160ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

AHI1 ATRNL1 HERC1 CSMD3 CHRM3 RYR2

3.48e-0620091648d801219bc771d6c7e151dc88ca4c179988de85
ToppCellE18.5-samps-Epithelial-Epithelial-non_alveolar-Club_cell|E18.5-samps / Age Group, Lineage, Cell class and subclass

TMPRSS13 KLHL30 FUT9 MUC2 CLDN10

1.38e-0514991582edfecb7981d8c336cf9da7aa7e2b3f7a017a3f
ToppCellE18.5-samps-Epithelial-Epithelial-non_alveolar|E18.5-samps / Age Group, Lineage, Cell class and subclass

TMPRSS13 KLHL30 FUT9 MUC2 CLDN10

1.38e-0514991514a01ae540db8a350ea26a350b2e6ce6c07639d9
ToppCellfacs-Kidney|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UGT3A1 FUT9 ABCG2 CLDN10 ACOT12

2.45e-05168915d2f17a470e04f8f0edb111894027bcfc6ee1a12f
ToppCellsevere_COVID-19-HSPC|severe_COVID-19 / disease group, cell group and cell class (v2)

CLEC9A BIRC7 TM4SF1 CHRM3 CLDN10

2.90e-051749156d35bacf073537b272ff821e604c899fb9ce6a7c
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Endothelial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP6 GBP4 ABCG2 TM4SF1 PLXNA2

3.15e-05177915ca5a30b3e7bcfdd8de01ceaf7449735b5cd503af
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Endothelial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP6 GBP4 ABCG2 TM4SF1 PLXNA2

3.15e-05177915f471f7747d6e8db7546899019af9508f48a14f89
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Endothelial-endothelial_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP6 GBP4 ABCG2 TM4SF1 PLXNA2

3.15e-05177915cd0684b876c2a7d5fe7e2773e8e25bb61ecbc795
ToppCellPND07-28-samps-Endothelial-Postnatal_endothelial-endothelial_cells_C|PND07-28-samps / Age Group, Lineage, Cell class and subclass

GBP4 KLHL30 ABCG2 TM4SF1 CHRM3

3.15e-051779156da88c358b3a2e47fa3472217a38b6b00ad7b280
ToppCellCOVID-19-kidney-PCT-S1/S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

DPEP1 CYP4A11 UGT3A1 CLDN10 SLC47A2

3.24e-0517891523a12d3d971b857d5be8e907334d1f6b49eeeb32
ToppCellCOVID-19-kidney-Stressed_PCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

DPEP1 CYP4A11 UGT3A1 CLDN10 SLC47A2

3.50e-051819156980ea624151da32b7f537f263e40fcb87a02e81
ToppCellhealthy_donor-Myeloid-Monocytic-SC_&_Eosinophil|healthy_donor / Disease condition, Lineage, Cell class and subclass

ITGA2B CHRM3 CLDN10 RYR3 TAFA2

3.60e-051829156bd6c32c48fecd6d03ac8a09e405b3b99bdc12ae
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D175|Adult / Lineage, Cell type, age group and donor

PLXNA4 WDR18 RIPK4 THSD7B RYR3

3.60e-05182915ad4d74d8b19976e1ccc3c5ba8013199338cf6fd8
ToppCell(8)_CD34_progenitor|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

CLEC9A TM4SF1 CHRM3 CLDN10 RYR3

3.99e-05186915943c604a7cd873faf510096d094100512ba2d6bc
ToppCell(8)_CD34_progenitor|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

CLEC9A TM4SF1 CHRM3 CLDN10 RYR3

3.99e-05186915e69a986b8618effd61875fda528a2e44aab11868
ToppCellPCW_13-14-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

GBP4 FUT9 THSD7B TM4SF1 CHRM3

4.20e-05188915b66f1f08827dd6c48583d871f9f33ea41e48bfb2
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ATRNL1 PLXNA4 KIAA1755 CHRM3 PLXNA2

4.20e-051889153004e961d214919e08c7cd5f10c3de5cf85b35a3
ToppCelldroplet-Mammary_Gland-nan-3m-Endothelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP6 GBP4 ABCG2 TM4SF1 PLXNA2

4.31e-051899151d4ad307c0606957dd7bf8da84450e5193cf4a50
ToppCelldroplet-Mammary_Gland-nan-3m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP6 GBP4 ABCG2 TM4SF1 PLXNA2

4.31e-05189915b952026044d5f6c0adce60cf24f6e0199e6f8757
ToppCelldroplet-Mammary_Gland-nan-3m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP6 GBP4 ABCG2 TM4SF1 PLXNA2

4.31e-0518991525781edbd08c6e413740b796ecc8ba1934bd3aa5
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DNAH17 PLXNA4 CLDN22 CLDN10 SLC47A2

4.41e-051909151cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DNAH17 PLXNA4 CLDN22 CLDN10 SLC47A2

4.41e-0519091559bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCellPCW_10-12-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

GBP4 FUT9 THSD7B TM4SF1 CHRM3

4.41e-051909157ba2be2630183df86de21689289a8620a4cd507e
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)

AHI1 JADE3 PGAP1 HERC1 KDM6A

4.53e-051919151ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCelldroplet-Mammary_Gland-nan-18m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR PLXNA4 ABCG2 TM4SF1 PLXNA2

4.64e-05192915945153c41dde6e90d103206955e1707b54eb0665
ToppCelldroplet-Mammary_Gland-nan-18m-Endothelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR PLXNA4 ABCG2 TM4SF1 PLXNA2

4.64e-051929156ab50579c63f31ca2cd41063a99b129f11c07510
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A2 LIFR ABCG2 TM4SF1 CHRM3

4.87e-05194915e8102c8811333f04de7280b7d9b6b85cebb815ac
ToppCellPCW_10-12-Endothelial-Endothelial_immature-endo_immature4_(5)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DPEP1 GBP4 THSD7B TM4SF1 CHRM3

4.87e-0519491553a5e8863d79a052dff0758f389be5ac3883c721
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A2 LIFR ABCG2 TM4SF1 CHRM3

4.87e-051949154b0d63babb8a46ff45731d5f82b29ccaf6c9402d
ToppCellPCW_10-12-Endothelial-Endothelial_immature-endo_immature_arterial1_(12)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DPEP1 GBP4 THSD7B TM4SF1 CHRM3

4.99e-051959153826bfafe85f8aa9a508202ceb2b02e81b090498
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

AHI1 ATRNL1 CSMD3 CHRM3 RYR2

5.12e-05196915676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DPEP1 ABCG2 HERC2 TM4SF1 PLXNA2

5.37e-051989150a4626b51ba8b52acbaf616f0ced850079cd7149
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

AHI1 ATRNL1 CSMD3 CHRM3 RYR2

5.37e-05198915c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

AHI1 ATRNL1 CSMD3 CHRM3 RYR2

5.37e-051989156d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

AHI1 ATRNL1 CSMD3 CHRM3 RYR2

5.37e-051989158ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

AHI1 ATRNL1 CSMD3 CHRM3 RYR2

5.37e-051989154ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellCOVID-19-kidney-Epithelial_(EC)|COVID-19 / Disease (COVID-19 only), tissue and cell type

THSD7B CSMD3 CHRM3 RYR3

1.60e-04133914a8abb6b54862123961ae6defbf251ee6e9575258
ToppCellCOVID-19-kidney-Technical/muscle_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

ATRNL1 THSD7B TAFA4 CSMD3

1.89e-04139914a1945b07f177cde40e7eea03a19236ce76165857
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7.Syt6-Tshz2-Nrep_(Subiculum_and_Entorhinal_Cortex)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CLDN24 TMPRSS13 UGT3A1

2.05e-04569137b7aaa514a3e85250d6279e0770a9409c4b0b199
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7.Syt6-Tshz2-Nrep_(Subiculum_and_Entorhinal_Cortex)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CLDN24 TMPRSS13 UGT3A1

2.05e-045691317c37bdd1f9733c3823e98ed4d1cd0ca9db66e9c
ToppCellParenchymal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ATRNL1 ZNF454 CHRM3 CLDN10

2.11e-0414391492ddc3e3f6ba78dd9daeb272c12503ec2650a874
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CLEC9A UGT3A1 PODXL2 ABCG2

2.17e-04144914f501e11b1d051ca67124137017a79a2d5bb6ae87
ToppCellCOVID-19-kidney-Technical/muscle_(PCT)|kidney / Disease (COVID-19 only), tissue and cell type

THSD7B TAFA4 CSMD3 RYR2

2.28e-04146914c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

ATRNL1 FUT9 THSD7B CSMD3

2.41e-04148914d6ac5972267254651dfbe16bb4e9a62228093cc7
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|COVID-19 / Disease (COVID-19 only), tissue and cell type

ATRNL1 THSD7B TAFA4 CSMD3

2.53e-041509140205318a870e091add66ee4305747dda9f51510d
ToppCelldroplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____proximal_tube_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AHI1 JADE2 PGAP1 PLXNA4

3.09e-041589141d78578dc1f8ba43dacdccae1082c0b9d749f64d
ToppCell10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_dendritic|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CLEC9A MUC2 TM4SF1 CHRM3

3.39e-04162914233011408f022647932c81ebab78f9813e3c6833
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|kidney / Disease (COVID-19 only), tissue and cell type

DOCK2 THSD7B CSMD3 RYR2

3.47e-0416391419c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

PLXNA4 THSD7B CHRM3 RYR3

3.47e-041639141e8730d75cccf7292010683ab4e81a69d8e3bfa9
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FAM53B RIPK4 CLDN10 SLC47A2

3.55e-04164914fe11fcce4ba7f44ba2989ea3705916b67e75f8e7
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FAM53B RIPK4 CLDN10 SLC47A2

3.55e-04164914b6beb8548ac0dd07e8a580a938e5ee4bf25a3c1f
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GBP4 TM4SF1 WDFY1 SHQ1

3.64e-0416591462457b7b74c6eae42d91d65e7dc6df6bf8e061f7
ToppCellNS-control-d_0-4-Myeloid-pDC|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DOCK2 POP1 PLXNA4 KIAA1586

3.64e-041659148b2d43d7c4ee07bd999bd51bc15117ce1fbb2d86
ToppCellcontrol-Myeloid-pDC|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DOCK2 POP1 PLXNA4 KIAA1586

3.64e-04165914243c74adf8d993ff92acbff2768bdc5a1693eca3
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UGT3A1 FUT9 ABCG2 ACOT12

3.72e-041669140868f45d8d39ad39b5cee5e81ac3dd4dc512775d
ToppCelldroplet-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UGT3A1 FUT9 ABCG2 ACOT12

3.89e-04168914dd48da83c32d41a62f80cd7e5e5c64e42776fa27
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLC6A2 LIFR ABCG2 TM4SF1

3.98e-0416991458136b8a0bf2dab45c91a053ef7225ea49ccb871
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLC6A2 LIFR ABCG2 TM4SF1

3.98e-0416991404c6ed38e1d1befba5ef5f37a3c1e045a0b163d6
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXNA4 CSMD3 RYR2 RYR3

3.98e-0416991412bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

CCNT2 ZNF268 ZNF629 CLDN10

4.16e-041719146a2f88c2a62cb2f69797804e24eb1137a3e148de
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

CCNT2 ZNF268 ZNF629 CLDN10

4.16e-041719149be3554626408bb897d1f1c43b3ab4a92651f2e2
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLC6A2 ABCG2 MYRFL TM4SF1

4.25e-04172914fc092a0631555d79e00ef9890cbd806e15bca2d4
ToppCellClub-club-3|World / Class top

KLHL30 FUT9 CLDN22 CLDN10

4.25e-0417291434fbb82a2ec77dd183cf26b38edeb7e936b707bc
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLC6A2 ABCG2 MYRFL TM4SF1

4.25e-04172914745725bd10c82017d678463b8fef0d2dcf09a8fd
ToppCellTCGA-Colorectal-Solid_Tissue_Normal-Colon_normal_tissue|TCGA-Colorectal / Sample_Type by Project: Shred V9

LIFR CLEC9A CD163L1 ABCG2

4.25e-0417291494842346c84542a5243bd765e49f4af8bc5182db
ToppCellTCGA-Colorectal-Solid_Tissue_Normal-Colon_normal_tissue-Colon_normal_tissue|TCGA-Colorectal / Sample_Type by Project: Shred V9

LIFR CLEC9A CD163L1 ABCG2

4.25e-041729145d654dd030ed22a701e15c5f09002951d99a52e8
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell|Adult / Lineage, Cell type, age group and donor

PLXNA4 THSD7B RYR2 RYR3

4.35e-04173914a5331721bd9f9a66530dd4ffe28cb3a5a8cad8fc
ToppCelldroplet-Fat-SCAT-30m-Endothelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP4 ABCG2 TM4SF1 PLXNA2

4.35e-04173914eb58b0189e71e38d4f4f1cf544a82cde8d1c86bc
ToppCell10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-HSC/MPP|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

CLEC9A GBP4 CHRM3 CLDN10

4.35e-0417391434357f0e22c4b6d84582492c82c1ea733ca8477d
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF775 PGAP1 KIAA1586 ZNF454

4.44e-041749149bb8159a62640756d18ecbade3bf32bcbb7dd590
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_ILC|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF775 PGAP1 KIAA1586 ZNF454

4.44e-04174914e70cc623a3a6aceec813ed852fec0c4240561133
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Degenerative_Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DNAH17 PLXNA4 CLDN10 SLC47A2

4.44e-0417491446bd0ef7d0541386de7a901d85d53d0176dc92bf
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF775 PGAP1 KIAA1586 ZNF454

4.44e-04174914b6725086fe5a2b057c7c495ec63c970ac52c2580
ToppCellTCGA-Colorectal-Recurrent_Tumor|TCGA-Colorectal / Sample_Type by Project: Shred V9

CYP4A11 UGT3A1 ITIH1 ACOT12

4.54e-041759147f74961436f88c0e380819095e6104489914d765
ToppCellTCGA-Colorectal-Recurrent_Tumor-Colorectal_Adenocarcinoma|TCGA-Colorectal / Sample_Type by Project: Shred V9

CYP4A11 UGT3A1 ITIH1 ACOT12

4.54e-04175914bee8f31f036dfcf9fc6ed29156554771a9ee3c60
ToppCellfacs-Aorta|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR GBP4 ABCG2 TM4SF1

4.64e-041769140b3491451be02c18a16cdb875645be47eb867a7f
ToppCellFetal_29-31_weeks-Epithelial-lung_goblet_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SYCP2 CLDN22 CHRM3 CLDN10

4.74e-04177914a4c001a8e44142babf9f24dfe6f7b73a70b11b16
ToppCellsevere_COVID-19-HSPC|World / disease group, cell group and cell class (v2)

CLEC9A TM4SF1 CHRM3 CLDN10

4.74e-04177914289f6aed6f054b04b01659434d8c8b467d1bf5dd
ToppCellFetal_29-31_weeks-Epithelial-lung_goblet_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SYCP2 CLDN22 CHRM3 CLDN10

4.74e-04177914363e07b0f347f3716d530a28ead854b98e27d37c
ToppCell10x5'v1-week_17-19-Hematopoietic-HSC/MPP_and_pro-MEP|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

TMPRSS13 ITGA2B CHRM3 CLDN10

4.84e-04178914b8c301d65c0f37941e8e9414d55e90edb6ecc195
ToppCellfacs-Lung-3m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_bronchioalveolar_tree|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMPRSS13 FUT9 CLDN22 RIPK4

4.84e-04178914b89c4d015b44bf538aa39969ef8778877c8023f1
ToppCellfacs-Lung-18m-Endothelial-venous_endothelial-vein_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC6A2 LIFR ABCG2 TM4SF1

4.84e-04178914ebfae386a518ea33911ba3ff40464c94d18ef695
ToppCellfacs-Lung-3m-Epithelial-airway_epithelial-respiratory_basal_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMPRSS13 FUT9 CLDN22 RIPK4

4.84e-04178914fb8f8d95f6b08378fb42c4076ee040276faa296f
ToppCellfacs-Lung-18m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC6A2 LIFR ABCG2 TM4SF1

4.84e-04178914ccd37575b60102f5e647c01546e8ff8fec638bd7
ToppCellfacs-Lung-18m-Endothelial-venous_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC6A2 LIFR ABCG2 TM4SF1

4.84e-0417891487b04753650e45f12299c8456fb980d6c0d5961c
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXNA4 RIPK4 THSD7B TAFA2

4.94e-04179914479116ac65488c60104a053530830763ec1f95b2
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXNA4 RIPK4 THSD7B TAFA2

4.94e-041799141dfc0cb8b369aef35c59f3d4c52603dc9f3728c1
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CYP4A11 KIAA1755 CLDN10 SLC47A2

4.94e-04179914d1ef7e1cb00336118e387b47f4f8120f53584391
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXNA4 RIPK4 THSD7B TAFA2

4.94e-0417991469a1b3b05c921de6343ffe6ad998aa2b804312a7
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DNAH17 PLXNA4 CLDN10 SLC47A2

4.94e-0417991455bc69f107fc710db7617c428575792adfdbbcc1
ToppCelldroplet-Fat-Gat-18m-Endothelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP6 GBP4 ZNF629 TM4SF1

4.94e-0417991408cf9986804a6417a9afb19b50c69a3554f71ec6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DPEP1 CYP4A11 CLDN10 SLC47A2

5.05e-04180914f8bdfd7bf7b3d52c659a29d8f5f80858e79da83e
ToppCell(5)_Epithelial_cells-(5)_Glands_mucous|(5)_Epithelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

CLDN22 CHRM3 CLDN10 RYR2

5.05e-04180914a4118adaf4b09e2ca01b662ed60e7bbf32a24d58
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DPEP1 CYP4A11 CLDN10 SLC47A2

5.05e-041809141363b3254470f6ff98630d1df83a1bdbacc137e0
ToppCelldroplet-Kidney|droplet / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UGT3A1 FUT9 ABCG2 CLDN10

5.05e-041809147e5f497699876ac8e1ce780626c6f5a1f6f5f079
ToppCellCOVID-19-kidney-tDL|COVID-19 / Disease (COVID-19 only), tissue and cell type

DPEP1 UGT3A1 CLDN10 SLC47A2

5.05e-04180914864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PODXL2 THSD7B TAFA4 RYR3

5.05e-04180914b6efdb4d319ef6f87f559acd974e5a71b06a2322
ToppCellFetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ATRNL1 PLXNA4 THSD7B RYR3

5.15e-0418191425915e2500430a902db37d79a749ce2990b69810
DrugConvolamine hydrochloride [500-56-1]; Up 200; 11.8uM; MCF7; HT_HG-U133A

ZSCAN32 JADE3 ATXN7L1 TM4SF1 CHRM3 RYR2 HIRA

9.37e-061918872771_UP
Drugestradiol, USP; Up 200; 0.1uM; PC3; HT_HG-U133A

SEPTIN8 CCNT2 AHI1 ATXN7L1 ZNF629 TFIP11 RYR2

1.18e-051988871208_UP
DrugUngerine nitrate; Down 200; 10.2uM; PC3; HT_HG-U133A

TPP2 CCNT1 CCNT2 PGAP1 FAM53B KDM6A HIRA

1.18e-051988875816_DN
Drugaspirin, USP; Down 200; 100uM; MCF7; HT_HG-U133A_EA

TPP2 CCNT2 MED16 PGAP1 WDR18 PODXL2 RXYLT1

1.22e-05199887984_DN
Diseasecongenital myopathy 1A (implicated_via_orthology)

RYR2 RYR3

2.46e-053852DOID:3529 (implicated_via_orthology)
Diseasemalignant hyperthermia (implicated_via_orthology)

RYR2 RYR3

2.46e-053852DOID:8545 (implicated_via_orthology)
Diseaseosteoarthritis

DPEP1 ZNF268 ATRNL1 KIAA1755 THSD7B CSMD3

4.52e-05222856MONDO_0005178
Diseaselevel of lactase/phlorizin hydrolase in blood serum

CCNT2 THSD7B

1.22e-046852OBA_2042177
Diseaseamino acid measurement

SLC6A2 CCNT2 ABCG2 PRKDC MUC2 CHRM3 PLXNA2 RYR2 RYR3

1.47e-04678859EFO_0005134
Diseasehippocampal volume

FAM53B ABCG2 PLXNA2 RYR2 RYR3 TAFA2

2.22e-04297856EFO_0005035
Diseaseaxin-2 measurement

MED16 ITIH1

3.64e-0410852EFO_0801400
Diseaseurate measurement, bone density

SLC6A2 GBP4 FBXO42 PLXNA4 KIAA1755 RIPK4 PRKDC CHRM3

4.18e-04619858EFO_0003923, EFO_0004531
Diseaseglycerate measurement

THSD7B RYR3

8.40e-0415852EFO_0021029
Diseaseskin sensitivity to sun

DPEP1 HERC2

1.36e-0319852EFO_0004795

Protein segments in the cluster

PeptideGeneStartEntry
HLACKWSNWEIPVST

CCNT2

201

O60583
PVSWVAHKTVQEFWD

CLDN24

136

A6NM45
EKNHWWSHPLPTCDA

CSMD3

1051

Q7Z407
NVLWKTEPFSLWACT

LINC00696

91

Q6ZRV3
VVEAFEWWSKCPRNH

AHI1

511

Q8N157
QQLPHCSQSWAQWKL

C2orf27A

101

P0DPF5
CHFWFTTKSWKPSSE

CHRM3

311

P20309
LSPWGLWKNHVALAC

ABCG2

621

Q9UNQ0
QKWVETFPSACPHWL

CYP4A11

76

Q02928
WDPHFVSCEVIDWVS

ACOT12

416

Q8WYK0
WTEHAKWFPSCQFLL

BIRC7

141

Q96CA5
WICLEEWKKHSSSTG

ANKIB1

546

Q9P2G1
IHLACKWSNWEIPVS

CCNT1

201

O60563
WVDDIQCPKTHISIW

CD163L1

1206

Q9NR16
WANLWKACVTDSTGV

CLDN10

46

P78369
PWSSWIDAAKLHCSD

ATXN7L1

46

Q9ULK2
VWASTHWQGTAVCPL

RBAKDN

81

A6NC62
TWSTTQAWCFPLKEA

KLHL30

341

Q0D2K2
IPWDSTQVICKDWSN

PODXL2

371

Q9NZ53
HTYSPSKNWWNCIVT

FBXO42

211

Q6P3S6
HLWSVQADSPCVANW

MKKS

476

Q9NPJ1
SKDPWHGAEVSCWFI

ITIH1

876

P19827
TLPCCAETHKWAWFR

HERC2

3861

O95714
AWEAPWCTVSEVTKL

KIAA1755

601

Q5JYT7
EKLVCWVVSNWNPEH

FUT9

186

Q9Y231
PNEWAWLECFSTTIK

HERC1

3921

Q15751
NWDPTGTKKIWHCES

KDM6A

1011

O15550
QIPDAWSCAWSLSIH

DCAF4L2

181

Q8NA75
TKWVHVSCALWIPEV

JADE2

271

Q9NQC1
SIWECLPEKDSSLWH

FAM53B

66

Q14153
PSSPWLDWSSHNVKC

PLXNA2

841

O75051
HTWKSNCLPLRFWVN

PLXNA2

1736

O75051
HTWKSNCLPLRFWVN

PLXNA4

1736

Q9HCM2
WDATPFVKSWSNCNH

KIAA1586

746

Q9HCI6
TWKAQSTCHDKLDWL

MUC2

556

Q02817
PCAWQWSAAVVVHDC

KBTBD2

416

Q8IY47
KWQPCHSVPWHSLLN

MYRFL

216

Q96LU7
VQSETKGIWMWCVPH

GBP4

86

Q96PP9
VQSETKGIWMWCVPH

GBP6

71

Q6ZN66
GWTPLHSACKWNNTR

ANKRD49

141

Q8WVL7
WEKWSKSTHCPSVPL

MED16

21

Q9Y2X0
WWIETCKKPDSVSLH

POP1

466

Q99575
PVSWVAHKTVQEFWD

CLDN22

136

Q8N7P3
LHTWLLKWSDEQCAS

DOCK2

1246

Q92608
PAVVNCTAIDWFHEW

DNAH17

2946

Q9UFH2
IKCVWNKNHCESWES

ATRNL1

631

Q5VV63
KWCANPDWIHIDTTP

G6PC2

241

Q9NQR9
DVAWSPHDAWLASCS

HIRA

136

P54198
LTHSCNTPWADNWLV

DPEP1

166

P16444
KSESGDWHCTASWKT

SEH1L

41

Q96EE3
KLCWVSAREHWQPQE

RXYLT1

296

Q9Y2B1
EDTTGEACWWTIHPA

RYR2

151

Q92736
EACWWTIHPASKQRS

RYR2

156

Q92736
GTKWAHVSCALWIPE

JADE3

271

Q92613
HHWSWASDMPLECAI

LIFR

201

P42702
APSCVDASIVEQKWW

TAFA2

81

Q8N3H0
PSCVEASIVIQKWWC

TAFA4

91

Q96LR4
SFTLNLPWTDCGHTW

SLC6A2

166

P23975
PQWVLTAAHCIFWKD

PRSS29P

106

A6NIE9
KLHLETWAGWSSQCL

SLC47A2

271

Q86VL8
SWSSQEHLEWEPACQ

KIFC3

781

Q9BVG8
SANIEWKLTLWTTCG

RNF215

211

Q9Y6U7
PTLCWFETWTNVHDI

SHQ1

306

Q6PI26
TWVSTDHLSIVWCKQ

PGAP1

276

Q75T13
PMWSCIVWELHSGAN

WDR18

16

Q9BV38
KWVHVSCALWIPEVS

JADE1

276

Q6IE81
VACAPWQHWNVLEKT

ITGA2B

136

P08514
HVHWKTWLAIKCSPS

RIPK4

41

P57078
WSIWHTSQENCLKEG

CLEC9A

131

Q6UXN8
CLLWLKDSHCAPTWK

CLUL1

11

Q15846
ATWTYVTTHPWLCLT

PIGV

341

Q9NUD9
QHLSEAWRCWKANIP

PRPF8

711

Q6P2Q9
GVIWTCQSSHWPRDV

UGT3A1

326

Q6NUS8
LASDSKWPWQVSLHF

TMPRSS13

331

Q9BYE2
CPNTVWKIDDLMDWH

ZNF268

151

Q14587
PHEAFSKLWELCCQW

ZSCAN32

51

Q9NX65
SPWAHSANKDSLALW

TBC1D8B

851

Q0IIM8
EACWWTIHPASKQRS

RYR3

146

Q15413
LASSEFTWWQPHAKD

SPATA31D1

351

Q6ZQQ2
IHSKWACWTPVTNIE

SYCP2

611

Q9BX26
GWTHCASFTENWLPI

TPP2

1226

P29144
CGKSFSWWSALTIHQ

ZNF775

451

Q96BV0
KASVEPLNCSSWWPA

SEPTIN8

451

Q92599
WICKPWNLARSLDTH

TTLL12

416

Q14166
WSECTEPKHIVEWNV

TM4SF1

146

P30408
PCWQFISWISHMVAL

PRKDC

3491

P78527
WVSWKCHLKATEASQ

nan

701

Q3C1V9
SSSHWKCASLLEWQC

ZNF454

116

Q8N9F8
GRPHQFDWKSSCETW

WSB2

16

Q9NYS7
NDHSCMQLHWETSPW

THSD7B

656

Q9C0I4
PTPSDWTKACEASWQ

ZNF629

101

Q9UEG4
WTLCNHELCWSHTPK

TMEM202

96

A6NGA9
KWHFNETVLTVWSAP

PPP4C

246

P60510
TEWVISTGHDKCVSW

WDFY1

126

Q8IWB7
KWLQVLCSWLSNSPN

TFIP11

661

Q9UBB9