Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	zf-C2H2	ZNF668 ZNF547 ZNF335 TRPS1 ZNF347 ZNF575 ZNF778 ZNF700 ZNF785 ZNF433	8.09e-04	693	81	10	PF00096
Domain	ZnF_GATA	MTA2 TRPS1	1.19e-03	12	81	2	SM00401
Domain	ZINC_FINGER_C2H2_2	ZNF668 ZNF547 ZNF335 TRPS1 ZNF347 ZNF575 ZNF778 ZNF700 ZNF785 ZNF433	1.87e-03	775	81	10	PS50157
Domain	Znf_GATA	MTA2 TRPS1	1.88e-03	15	81	2	IPR000679
Domain	GATA	MTA2 TRPS1	1.88e-03	15	81	2	PF00320
Domain	ZINC_FINGER_C2H2_1	ZNF668 ZNF547 ZNF335 TRPS1 ZNF347 ZNF575 ZNF778 ZNF700 ZNF785 ZNF433	1.91e-03	777	81	10	PS00028
Domain	GATA_ZN_FINGER_1	MTA2 TRPS1	2.14e-03	16	81	2	PS00344
Domain	GATA_ZN_FINGER_2	MTA2 TRPS1	2.14e-03	16	81	2	PS50114
Domain	Znf_C2H2-like	ZNF668 ZNF547 ZNF335 TRPS1 ZNF347 ZNF575 ZNF778 ZNF700 ZNF785 ZNF433	2.28e-03	796	81	10	IPR015880
Domain	Znf_C2H2	ZNF668 ZNF547 ZNF335 TRPS1 ZNF347 ZNF575 ZNF778 ZNF700 ZNF785 ZNF433	2.47e-03	805	81	10	IPR007087
Domain	ZnF_C2H2	ZNF668 ZNF547 ZNF335 TRPS1 ZNF347 ZNF575 ZNF778 ZNF700 ZNF785 ZNF433	2.54e-03	808	81	10	SM00355
Domain	-	ZNF668 ZNF547 ZNF335 ZNF347 ZNF575 ZNF778 ZNF700 ZNF785 ZNF433	2.66e-03	679	81	9	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF668 ZNF547 ZNF335 ZNF347 ZNF575 ZNF778 ZNF700 ZNF785 ZNF433	3.08e-03	694	81	9	IPR013087
Domain	KRAB	ZNF547 ZNF347 ZNF778 ZNF700 ZNF785 ZNF433	4.62e-03	358	81	6	PS50805
Domain	KRAB	ZNF547 ZNF347 ZNF778 ZNF700 ZNF785 ZNF433	4.62e-03	358	81	6	PF01352
Domain	KRAB	ZNF547 ZNF347 ZNF778 ZNF700 ZNF785 ZNF433	5.34e-03	369	81	6	SM00349
Domain	KRAB	ZNF547 ZNF347 ZNF778 ZNF700 ZNF785 ZNF433	5.41e-03	370	81	6	IPR001909
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MTA2 HSPG2 FLNC VAC14 LRFN1 GBF1 ABL1 SUGP2 CASKIN1 ZNF335 PFAS TOR4A DOCK6 SPEN CEP170B	5.89e-08	1105	84	15	35748872
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MTA2 FLNC SUGP2 RPS15 LARP1 PFAS ATIC UQCRC2 SPEN PCM1 TP53	5.05e-07	653	84	11	22586326
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	KIDINS220 SQSTM1 ATG2B PFAS CEP170B PCM1 AXIN1	7.83e-07	209	84	7	36779422
Pubmed	Human transcription factor protein interaction networks.	HSPG2 SUGP2 RBM33 SQSTM1 TRPS1 MRPS23 RPS15 LARP1 UQCRC2 FOXA1 SPEN PCM1 TP53 SORD MRPL2	1.54e-06	1429	84	15	35140242
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	SLF2 RBM33 SQSTM1 TPRN PFAS BSN SPEN CEP170B PCM1 TP53	1.59e-06	588	84	10	38580884
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	MTA2 FLNC SUGP2 SQSTM1 LARP1 PFAS ATIC UQCRC2 PCM1	2.36e-06	477	84	9	31300519
Pubmed	Insights into selective activation of p53 DNA binding by c-Abl.	ABL1 TP53	5.76e-06	2	84	2	15661746
Pubmed	Attenuated clinical and osteoclastic phenotypes of Paget's disease of bone linked to the p.Pro392Leu/SQSTM1 mutation by a rare variant in the DOCK6 gene.	SQSTM1 DOCK6	5.76e-06	2	84	2	35241069
Pubmed	Stimulation of p53 DNA binding by c-Abl requires the p53 C terminus and tetramerization.	ABL1 TP53	5.76e-06	2	84	2	10629029
Pubmed	The effects of c-Abl mutation on developing B cell differentiation and survival.	ABL1 TP53	5.76e-06	2	84	2	19299624
Pubmed	AMPK β1 reduces tumor progression and improves survival in p53 null mice.	PRKAB1 TP53	5.76e-06	2	84	2	28544264
Pubmed	Homoharringtonine promotes BCR‑ABL degradation through the p62‑mediated autophagy pathway.	ABL1 SQSTM1	5.76e-06	2	84	2	31789418
Pubmed	Starvation induced autophagy promotes the progression of bladder cancer by LDHA mediated metabolic reprogramming.	SQSTM1 AXIN1	5.76e-06	2	84	2	34743698
Pubmed	p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling.	ABL1 TP53	5.76e-06	2	84	2	16380437
Pubmed	Zinc finger protein Zfp335 controls early T-cell development and survival through β-selection-dependent and -independent mechanisms.	ZNF335 TP53	5.76e-06	2	84	2	35113015
Pubmed	c-Abl: activation and nuclear targets.	ABL1 TP53	5.76e-06	2	84	2	10713716
Pubmed	Genetic features of TP53 mutation and its downstream FOXA1 in prostate cancer.	FOXA1 TP53	5.76e-06	2	84	2	35768267
Pubmed	Abl1 deletion in gut stem cells suppresses p53 induction and promotes colitis-associated tumor formation.	ABL1 TP53	5.76e-06	2	84	2	32652042
Pubmed	Meiotic Knockdown and Complementation Reveals Essential Role of RAD51 in Mouse Spermatogenesis.	DMC1 TP53	5.76e-06	2	84	2	28178517
Pubmed	Understanding the impact of 1q21.1 copy number variant.	PRKAB1 CHD1L	5.76e-06	2	84	2	21824431
Pubmed	Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation.	UQCRC2 TP53	5.76e-06	2	84	2	30674441
Pubmed	Mutant p53 dictates the oncogenic activity of c-Abl in triple-negative breast cancers.	ABL1 TP53	5.76e-06	2	84	2	28661474
Pubmed	c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency.	ABL1 TP53	5.76e-06	2	84	2	10805805
Pubmed	The role of autophagy in cadmium-induced acute toxicity in glomerular mesangial cells and tracking polyubiquitination of cytoplasmic p53 as a biomarker.	SQSTM1 TP53	5.76e-06	2	84	2	35624155
Pubmed	Human DDA3 is an oncoprotein down-regulated by p53 and DNA damage.	PSRC1 TP53	5.76e-06	2	84	2	18291097
Pubmed	Genetic disruption of Abl nuclear import reduces renal apoptosis in a mouse model of cisplatin-induced nephrotoxicity.	ABL1 TP53	5.76e-06	2	84	2	23660976
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	THAP4 COL24A1 ZNF668 GBF1 TPRN ZNF335 AMOTL1 TRPS1 PFAS TP53	6.45e-06	689	84	10	36543142
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	FLNC GBF1 SUGP2 TRPS1 LARP1 RITA1 CHD1L MRPL3 FOXA1 SPEN TP53	6.90e-06	857	84	11	25609649
Pubmed	Network organization of the human autophagy system.	MTA2 FLNC GBF1 SQSTM1 PRKAB1 ATG2B PFAS CEP170B	1.10e-05	437	84	8	20562859
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	MTA2 SUGP2 SQSTM1 TPRN TRPS1 BICRAL STK39 RAB11FIP1 FOXA1 CEP170B PCM1 TP53	1.51e-05	1116	84	12	31753913
Pubmed	AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes.	PRKAB1 TP53	1.73e-05	3	84	2	20861022
Pubmed	Involvement of c-Abl, p53 and the MAP kinase JNK in the cell death program initiated in A2E-laden ARPE-19 cells by exposure to blue light.	ABL1 TP53	1.73e-05	3	84	2	19052872
Pubmed	Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation.	TP53 AXIN1	1.73e-05	3	84	2	15526030
Pubmed	Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice.	ABL1 TP53	1.73e-05	3	84	2	11003672
Pubmed	Deacetylation of p53 modulates its effect on cell growth and apoptosis.	MTA2 TP53	1.73e-05	3	84	2	11099047
Pubmed	p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.	SQSTM1 TP53	1.73e-05	3	84	2	28512249
Pubmed	Cooperative roles of c-Abl and Cdk5 in regulation of p53 in response to oxidative stress.	ABL1 TP53	1.73e-05	3	84	2	18490454
Pubmed	Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation.	ABL1 TP53	1.73e-05	3	84	2	12110584
Pubmed	Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53.	SQSTM1 TP53	1.73e-05	3	84	2	16793543
Pubmed	Prognostic values of immune scores and immune microenvironment-related genes for hepatocellular carcinoma.	TP53 AXIN1	1.73e-05	3	84	2	32213661
Pubmed	p53 Protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis.	DMC1 TP53	1.73e-05	3	84	2	14764457
Pubmed	Expression of the zinc importer protein ZIP9/SLC39A9 in glioblastoma cells affects phosphorylation states of p53 and GSK-3β and causes increased cell migration.	SLC39A9 TP53	1.73e-05	3	84	2	27654922
Pubmed	Cross-talk between mutant p53 and p62/SQSTM1 augments cancer cell migration by promoting the degradation of cell adhesion proteins.	SQSTM1 TP53	1.73e-05	3	84	2	35439056
Pubmed	c-Abl inhibits breast cancer tumorigenesis through reactivation of p53-mediated p21 expression.	ABL1 TP53	1.73e-05	3	84	2	27626309
Pubmed	The dual role of p62 in ferroptosis of glioblastoma according to p53 status.	SQSTM1 TP53	1.73e-05	3	84	2	35216629
Pubmed	FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations.	FOXA1 TP53	1.73e-05	3	84	2	35920317
Pubmed	Stabilization and activation of p53 downregulates mTOR signaling through AMPK in mantle cell lymphoma.	PRKAB1 TP53	1.73e-05	3	84	2	19225536
Pubmed	Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion.	RAB11FIP1 TP53	1.73e-05	3	84	2	32640214
Pubmed	Autophagy regulates apoptosis by targeting NOXA for degradation.	SQSTM1 TP53	1.73e-05	3	84	2	29758299
Pubmed	Down-regulation of TRPS1 stimulates epithelial-mesenchymal transition and metastasis through repression of FOXA1.	TRPS1 FOXA1	1.73e-05	3	84	2	26969828
Pubmed	Ablation of ribosomal protein L22 selectively impairs alphabeta T cell development by activation of a p53-dependent checkpoint.	PTCRA TP53	1.73e-05	3	84	2	17555992
Pubmed	TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells.	SQSTM1 ZFYVE1	1.73e-05	3	84	2	22178386
Pubmed	Mouse DDA3 gene is a direct transcriptional target of p53 and p73.	PSRC1 TP53	1.73e-05	3	84	2	12082536
Pubmed	RAD51AP2 is required for efficient meiotic recombination between X and Y chromosomes.	DMC1 RAD51AP2	1.73e-05	3	84	2	35020426
Pubmed	Phosphorylation of the Mdm2 oncoprotein by the c-Abl tyrosine kinase regulates p53 tumor suppression and the radiosensitivity of mice.	ABL1 TP53	1.73e-05	3	84	2	27956626
Pubmed	Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status.	ABL1 TP53	1.73e-05	3	84	2	17409407
Pubmed	Downregulation of beta-catenin by p53 involves changes in the rate of beta-catenin phosphorylation and Axin dynamics.	TP53 AXIN1	1.73e-05	3	84	2	15064706
Pubmed	c-Abl tyrosine kinase activates p21 transcription via interaction with p53.	ABL1 TP53	1.73e-05	3	84	2	17339230
Pubmed	Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway.	AMOTL1 TP53	1.73e-05	3	84	2	30531834
Pubmed	Autophagy gene FIP200 in neural progenitors non-cell autonomously controls differentiation by regulating microglia.	SQSTM1 TP53	1.73e-05	3	84	2	28634261
Pubmed	The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products.	ABL1 TP53	1.73e-05	3	84	2	8612582
Pubmed	The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels.	PRKAB1 TP53	1.73e-05	3	84	2	21907923
Pubmed	EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.	SQSTM1 ATG2B LARP1 ZFYVE1 TP53	3.28e-05	150	84	5	32423001
Pubmed	Expression of BCL2, TP53, FOXA1, and GATA3 in pTa bladder cancer recurrence.	FOXA1 TP53	3.45e-05	4	84	2	38624056
Pubmed	RBP-J-interacting and tubulin-associated protein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma by activating the p53-Fbxw7 pathway.	RITA1 TP53	3.45e-05	4	84	2	25445601
Pubmed	Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C delta.	ABL1 TP53	3.45e-05	4	84	2	15289456
Pubmed	IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway.	PRKAB1 TP53	3.45e-05	4	84	2	21573174
Pubmed	Nuclear accumulations of p53 and Mdm2 are accompanied by reductions in c-Abl and p300 in zinc-depleted human hepatoblastoma cells.	ABL1 TP53	3.45e-05	4	84	2	16636310
Pubmed	c-Abl phosphorylates Hdmx and regulates its interaction with p53.	ABL1 TP53	3.45e-05	4	84	2	19075013
Pubmed	Targeting the PTP1B-Bcr-Abl1 interaction for the degradation of T315I mutant Bcr-Abl1 in chronic myeloid leukemia.	ABL1 SQSTM1	3.45e-05	4	84	2	36086954
Pubmed	The expression of p21 is upregulated by forkhead box A1/2 in p53-null H1299 cells.	FOXA1 TP53	3.45e-05	4	84	2	25281925
Pubmed	p53 target DDA3 binds ASPP2 and inhibits its stimulation on p53-mediated BAX activation.	PSRC1 TP53	3.45e-05	4	84	2	18793611
Pubmed	Development of a high-throughput screen to detect inhibitors of TRPS1 sumoylation.	TRPS1 TP53	3.45e-05	4	84	2	23772552
Pubmed	ZNF768 links oncogenic RAS to cellular senescence.	ZNF778 TP53	3.45e-05	4	84	2	34404770
Pubmed	Abl interconnects oncogenic Met and p53 core pathways in cancer cells.	ABL1 TP53	3.45e-05	4	84	2	21455220
Pubmed	ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer.	ZNF668 TP53	3.45e-05	4	84	2	21852383
Pubmed	Renal cell carcinoma escapes death by p53 depletion through transglutaminase 2-chaperoned autophagy.	SQSTM1 TP53	3.45e-05	4	84	2	27031960
Pubmed	Axin downregulates TCF-4 transcription via beta-catenin, but not p53, and inhibits the proliferation and invasion of lung cancer cells.	TP53 AXIN1	3.45e-05	4	84	2	20122174
Pubmed	MDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity.	TP53 AXIN1	3.45e-05	4	84	2	23826318
Pubmed	Identification of a novel p53-dependent activation pathway of STAT1 by antitumour genotoxic agents.	ABL1 TP53	3.45e-05	4	84	2	17992189
Pubmed	c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression.	ABL1 TP53	3.45e-05	4	84	2	22729085
Pubmed	Non genomic loss of function of tumor suppressors in CML: BCR-ABL promotes IκBα mediated p53 nuclear exclusion.	ABL1 TP53	3.45e-05	4	84	2	26295305
Pubmed	A positive role for c-Abl in Atm and Atr activation in DNA damage response.	ABL1 TP53	3.45e-05	4	84	2	20798688
Pubmed	Differential expression of progesterone receptor, FOXA1, GATA3, and p53 between pre- and postmenopausal women with estrogen receptor-positive breast cancer.	FOXA1 TP53	3.45e-05	4	84	2	24549642
Pubmed	RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J.	RITA1 SPEN	3.45e-05	4	84	2	21102556
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	GBF1 ABL1 SLF2 SQSTM1 LARP1 RAB11FIP1 DOCK6 CEP170B PCM1 TP53	4.34e-05	861	84	10	36931259
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	MTA2 SUGP2 AMOTL1 ATG2B LARP1 SPEN PCM1 TP53	5.58e-05	549	84	8	38280479
Pubmed	Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver.	ABL1 TP53	5.74e-05	5	84	2	22889954
Pubmed	Novel mechanisms of Na+ retention in obesity: phosphorylation of NKCC2 and regulation of SPAK/OSR1 by AMPK.	PRKAB1 STK39	5.74e-05	5	84	2	24808538
Pubmed	Impaired autophagy induces chronic atrophic pancreatitis in mice via sex- and nutrition-dependent processes.	SQSTM1 TP53	5.74e-05	5	84	2	25497209
Pubmed	Axin determines cell fate by controlling the p53 activation threshold after DNA damage.	TP53 AXIN1	5.74e-05	5	84	2	19731416
Pubmed	H2AFX and MDC1 promote maintenance of genomic integrity in male germ cells.	DMC1 TP53	5.74e-05	5	84	2	29437857
Pubmed	DNA mismatch repair-dependent activation of c-Abl/p73alpha/GADD45alpha-mediated apoptosis.	ABL1 TP53	5.74e-05	5	84	2	18480060
Pubmed	A Novel Role of Proline Oxidase in HIV-1 Envelope Glycoprotein-induced Neuronal Autophagy.	SQSTM1 TP53	5.74e-05	5	84	2	26330555
Pubmed	AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation.	TP53 AXIN1	5.74e-05	5	84	2	21057547
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	FLNC GBF1 SUGP2 RBM33 SQSTM1 LARP1 UQCRC2 ZFYVE1 SPEN	6.40e-05	724	84	9	36232890
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	MTA2 THAP4 SUGP2 RBM33 LARP1 BICRAL ATIC SPEN PCM1 TP53 SORD	6.96e-05	1103	84	11	34189442
Pubmed	Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway.	HSPG2 SQSTM1 PCM1	7.04e-05	33	84	3	29149599
Pubmed	The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination.	SQSTM1 TP53	8.59e-05	6	84	2	27528230
Pubmed	Loss of Ribosomal Protein Paralog Rpl22-like1 Blocks Lymphoid Development without Affecting Protein Synthesis.	PTCRA TP53	8.59e-05	6	84	2	35046107
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF668 ZNF547 ZNF335 TRPS1 ZNF347 ZNF575 ZNF778 ZNF700 ZNF785 ZNF433	1.52e-05	718	48	10	28
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	MTA2 TRPS1	7.09e-04	15	48	2	82
GeneFamily	Mitochondrial ribosomal proteins	MRPS23 MRPL3 MRPL2	1.21e-03	79	48	3	646
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RAB11FIP1 C2CD4C	4.10e-03	36	48	2	823
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSPG2 COL24A1 LRFN1 CPXM2 CCDC80 C2CD4C	1.52e-06	188	84	6	b382d18fb09fb2869f3c151efa71540a7f5ed229
ToppCell	3'-Child04-06-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNC KCNN1 DOCK6 KLKB1 TNXB	1.92e-05	173	84	5	85083b9ce20351dd69aa2327ad087b848b4307ff
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D231\|Adult / Lineage, Cell type, age group and donor	FLNC SPSB4 THSD1 C2CD4C TNXB	2.20e-05	178	84	5	c80ca7a2d3f976089a5e71d0cd9ba9a1c0bd2815
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Papillary_Renal_Cell_Carcinoma-8\|TCGA-Kidney / Sample_Type by Project: Shred V9	VAC14 SQSTM1 MRPS23 ATIC MRPL2	2.26e-05	179	84	5	8c6a84602b079bd357c66244371eb23dd9384918
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HSPG2 CPXM2 ZNF700 TNXB ZNF785	2.32e-05	180	84	5	40d4838a0ccb10d5e49266bc8a0037d27b75ccc2
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNC THSD1 C2CD4C KLKB1 TNXB	2.51e-05	183	84	5	764ea07621f77fbd13a877aed5806ae2b3dfb43e
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNC THSD1 C2CD4C KLKB1 TNXB	2.51e-05	183	84	5	38a54216458ad57f356bb4ddf272e1af8036ddeb
ToppCell	metastatic_Lymph_Node-Fibroblasts-COL14A1+_matrix_FBs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	HSPG2 FLNC CPXM2 CCDC80 TNXB	2.64e-05	185	84	5	506eee2c1b6e8acec3aa8b2c66868010006c4c14
ToppCell	390C-Endothelial_cells-Endothelial-F_(Lymphatics)\|390C / Donor, Lineage, Cell class and subclass (all cells)	FLNC SPSB4 THSD1 C2CD4C TNXB	2.85e-05	188	84	5	aa69e3f44d506f5ef358a3374ac5160d847c858f
ToppCell	390C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	FLNC SPSB4 THSD1 C2CD4C TNXB	2.85e-05	188	84	5	1f40b959777d18ad88d239df8cca304f062ba04c
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 FLNC CCDC80 THSD1 TNXB	2.85e-05	188	84	5	26915db8863f4115b46a81982e187322e21600fd
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 FLNC CCDC80 THSD1 TNXB	2.85e-05	188	84	5	3f76c0f912f8f023ea425be7f43593b3d7f967e3
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSPG2 COL24A1 FLNC CCDC80 TNXB	2.85e-05	188	84	5	bba6b273bd47dd0e27fde914e9e6fc9d76fd5176
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 FLNC CCDC80 THSD1 TNXB	2.85e-05	188	84	5	61ee7b152745164293d8a44ef91ee2393efbdca5
ToppCell	wk_15-18-Endothelial-Lymph_endothelial-Intermediate_lymphatic_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FLNC CPXM2 THSD1 C2CD4C TNXB	3.08e-05	191	84	5	d25ac3206fe205a100cfee26431ff32c14c1938f
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	NYAP2 PLCL2 SLC4A10 BSN CEP170B	3.08e-05	191	84	5	5d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCell	Entopeduncular-Neuronal-Inhibitory\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	NYAP2 PLCL2 SLC4A10 BSN CEP170B	3.08e-05	191	84	5	73dae4cdea86aec62393ad7303dc7375a6b3fc86
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSPG2 FLNC CPXM2 CCDC80 TNXB	3.32e-05	194	84	5	5594f7437448cb4b37d2d100f44d30c4a367df26
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNC CCDC80 STK39 FOXA1 TNXB	3.48e-05	196	84	5	2029f58ce6a7b8c35d3a7496c3341391990909ce
ToppCell	Mesenchymal_cells-Arteriolar_fibro.\|Mesenchymal_cells / Lineage and Cell class	HSPG2 CPXM2 QPRT CCDC80 TNXB	3.57e-05	197	84	5	cb321836980e7b4efbb9284c6af7ccd34079d2be
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Mesothelial-1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	COL24A1 KCNN1 CCDC80 BSN TNXB	3.65e-05	198	84	5	2dc0510846cbc296a300b8465e7be9b39f479852
ToppCell	Parenchyma_Control_(B.)-Stromal-TX-Mesothelial-1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	COL24A1 KCNN1 CCDC80 BSN TNXB	3.65e-05	198	84	5	eb7e674d08a7aeb554c1e4797338280581b79989
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Mesothelial-1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	COL24A1 KCNN1 CCDC80 BSN TNXB	3.65e-05	198	84	5	364de83e30d842123fb92367f54b4bea57a47c84
ToppCell	Sepsis-URO-Lymphocyte-B-Plasmablast\|URO / Disease, condition lineage and cell class	DMC1 PTCRA ZNF778 PSRC1 PGBD2	3.74e-05	199	84	5	0df6cafb7f3b607cbe80b6f25b4fd62d421d01ee
ToppCell	NS-moderate-d_0-4-Epithelial\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CCDC80 RAB11FIP1 FOXA1 PCM1 SORD	3.83e-05	200	84	5	64462a18afca3c1a8548a857924b8166058bf958
Disease	omega-6 polyunsaturated fatty acid measurement	NYAP2 PTCRA ZNF335 TRPS1 DOCK6 PSRC1	1.64e-05	197	80	6	EFO_0005680
Disease	cholesterol in medium HDL measurement	NYAP2 TRPS1 DOCK6 PSRC1	2.04e-05	59	80	4	EFO_0021903
Disease	phospholipids in HDL measurement	NYAP2 TRPS1 DOCK6 PSRC1	2.32e-05	61	80	4	EFO_0022293
Disease	obsolete_red blood cell distribution width	NYAP2 ABL1 ZBED6 SQSTM1 PLCL2 UGT2B10 LARP1 STK39 DOCK6 ZFYVE1 TMEM40 AXIN1 SORD	6.43e-05	1347	80	13	EFO_0005192
Disease	drebrin-like protein measurement	NLRP12 KLKB1	7.22e-05	5	80	2	EFO_0020333
Disease	triglyceride measurement, high density lipoprotein cholesterol measurement	NYAP2 GBF1 TRPS1 UGT2B10 DOCK6 PSRC1	1.03e-04	274	80	6	EFO_0004530, EFO_0004612
Disease	rho GTPase-activating protein 30 measurement	NLRP12 KLKB1	1.51e-04	7	80	2	EFO_0802012
Disease	coiled-coil domain-containing protein 80 measurement	CCDC80 KLKB1	2.01e-04	8	80	2	EFO_0020268
Disease	testis-expressed sequence 29 protein measurement	NLRP12 KLKB1	2.01e-04	8	80	2	EFO_0802125
Disease	esophagus squamous cell carcinoma (is_implicated_in)	FOXA1 SPEN TP53	2.51e-04	45	80	3	DOID:3748 (is_implicated_in)
Disease	HEPATOCELLULAR CARCINOMA	TP53 AXIN1	2.58e-04	9	80	2	114550
Disease	Adult Hepatocellular Carcinoma	TP53 AXIN1	2.58e-04	9	80	2	C0279607
Disease	tumor necrosis factor receptor superfamily member 16 measurement	NLRP12 KLKB1	2.58e-04	9	80	2	EFO_0802168
Disease	Hepatocellular carcinoma	TP53 AXIN1	2.58e-04	9	80	2	cv:C2239176
Disease	Small Lymphocytic Lymphoma	RPS15 TP53	3.22e-04	10	80	2	C0855095
Disease	B-lymphoblastic leukemia/lymphoma (is_implicated_in)	ABL1 TP53	3.22e-04	10	80	2	DOID:0080630 (is_implicated_in)
Disease	B-CELL MALIGNANCY, LOW-GRADE	RPS15 TP53	3.22e-04	10	80	2	C1868683
Disease	Ductal Carcinoma	FOXA1 TP53	3.93e-04	11	80	2	C1176475
Disease	hematocrit	DMC1 VAC14 NYAP2 TRPS1 PLCL2 RPS15 PFAS BSN ZFYVE1 TMEM40	4.00e-04	1011	80	10	EFO_0004348
Disease	phospholipids in medium HDL measurement	TRPS1 DOCK6 PSRC1	4.55e-04	55	80	3	EFO_0022295
Disease	free cholesterol to total lipids in very large HDL percentage	NYAP2 TRPS1 DOCK6	4.55e-04	55	80	3	EFO_0022288
Disease	Myeloproliferative disease	ATG2B TP53	4.71e-04	12	80	2	C0027022
Disease	total lipids in medium HDL measurement	TRPS1 DOCK6 PSRC1	5.32e-04	58	80	3	EFO_0022310
Disease	free cholesterol in medium HDL measurement	NYAP2 TRPS1 DOCK6	5.32e-04	58	80	3	EFO_0022267
Disease	free cholesterol in HDL measurement	NYAP2 TRPS1 DOCK6	6.17e-04	61	80	3	EFO_0022264
Disease	total lipids in HDL measurement	NYAP2 TRPS1 DOCK6	6.78e-04	63	80	3	EFO_0022307
Disease	osteoporosis	STK39 AXIN1 HSP90AB3P	1.04e-03	73	80	3	EFO_0003882
Disease	phospholipids in large HDL measurement	NYAP2 TRPS1 DOCK6	1.04e-03	73	80	3	EFO_0022190
Disease	total lipids in large HDL	NYAP2 TRPS1 DOCK6	1.08e-03	74	80	3	EFO_0022189
Disease	stem Cell Growth Factor beta measurement	C12orf42 ZNF700 KLKB1	1.13e-03	75	80	3	EFO_0008292
Disease	lung non-small cell carcinoma (is_marker_for)	ABL1 FOXA1 TP53 AXIN1	1.17e-03	169	80	4	DOID:3908 (is_marker_for)
Disease	osteochondrodysplasia (is_implicated_in)	HSPG2 TRPS1	1.20e-03	19	80	2	DOID:2256 (is_implicated_in)
Disease	peripheral neuropathy, response to docetaxel trihydrate	VAC14 NYAP2	1.20e-03	19	80	2	EFO_0003100, GO_1902519
Disease	free cholesterol in large HDL measurement	NYAP2 TRPS1 DOCK6	1.31e-03	79	80	3	EFO_0022157
Disease	Adenocarcinoma of prostate	FOXA1 AXIN1	1.34e-03	20	80	2	C0007112
Disease	cholesterol in large HDL measurement	NYAP2 TRPS1 DOCK6	1.36e-03	80	80	3	EFO_0021900
Disease	corneal resistance factor	COL24A1 ABL1 CCDC80 FOXA1 ZFYVE1 HSP90AB3P	1.43e-03	451	80	6	EFO_0010067
Disease	Precursor B-cell lymphoblastic leukemia	ABL1 TP53	1.47e-03	21	80	2	C1292769
Disease	triacylglycerol 58:9 measurement	GBF1 TNXB	1.62e-03	22	80	2	EFO_0010443
Disease	linoleic acid measurement	NYAP2 ZNF335 DOCK6 PSRC1	1.66e-03	186	80	4	EFO_0006807
Disease	HMG CoA reductase inhibitor use measurement	NYAP2 TRPS1 UGT2B10 DOCK6	1.76e-03	189	80	4	EFO_0009932
Disease	smoking cessation	NYAP2 CPXM2 RBM33 PLCL2 BSN	1.92e-03	325	80	5	EFO_0004319
Disease	colon adenocarcinoma (is_marker_for)	PFAS FOXA1	2.09e-03	25	80	2	DOID:234 (is_marker_for)
Disease	Bone Diseases, Developmental	ABL1 TRPS1	2.44e-03	27	80	2	C0005941
Disease	phospholipid measurement, intermediate density lipoprotein measurement	ZNF335 TRPS1 PSRC1	2.50e-03	99	80	3	EFO_0004639, EFO_0008595
Disease	oral squamous cell carcinoma (is_implicated_in)	ABL1 TP53	2.62e-03	28	80	2	DOID:0050866 (is_implicated_in)
Disease	opioid use disorder	GBF1 PLCL2 KCNN1	2.64e-03	101	80	3	EFO_0010702

Protein segments in the cluster

Peptide	Gene	Start	Entry
GITGMSHRARPHGIS	nan	71	Q8N976
HREVRGPVLGHTATG	B3GALT5-AS1	6	P59052
SSKGSGRHHILSAGP	GPR20	331	Q99678
GHGKSPDHRGRVSSL	AMOTL1	926	Q8IY63
LHRVGPGDDRHSTKS	CEP170B	326	Q9Y4F5
KPIGGHILAHASTTR	DMC1	286	Q14565
GIHACRRGGVTLGHK	SORD	161	Q00796
KEGSSRTHRPGGKHG	CCDC74B	136	Q96LY2
RGEHTVHVGPRGSVR	C2CD4C	296	Q8TF44
HTPTRHGRNTVCGGK	ATG2B	1586	Q96BY7
HATIRGSHGGRKVPL	CCDC80	26	Q76M96
HRGIKGLVRDSHGKG	CPXM2	641	Q8N436
LLRGGSHFPHGISRV	RAD51AP2	1106	Q09MP3
PGVKRTVTHRTNSGG	RBM33	961	Q96EV2
EGATRGTTEPHSRGH	MTA2	411	O94776
KRGGSLPVRHQTHGS	HSPG2	2376	P98160
HKRGGSLPSHHQTRG	HSPG2	2761	P98160
HVLGAGPHVKRGSNT	UQCRC2	291	P22695
EARPGRHGHSIKRAS	CASKIN1	741	Q8WXD9
HPGGDRTGNHTSRAK	LARP1	656	Q6PKG0
LGSHRLHPATETGGR	PTCRA	191	Q6ISU1
SHSGKRGIPHSLSGL	KIDINS220	1621	Q9ULH0
VHADHGEPIGRGTKV	HSP90AB3P	146	Q58FF7
TKRHRSTPHLDGAGG	LRFN1	726	Q9P244
RASGKPSNVGHRLGH	KCNN1	81	Q92952
KTGGTTSPKHGRAEH	BSN	431	Q9UPA5
GVGRRRTKTPHTFPH	PCM1	71	Q15154
ETGHHAPGLKLRGTG	LCTL	211	Q6UWM7
GGRHGSVSLLRHPGT	FAM218A	51	Q96MZ4
KVTGPRLSGGHSLHE	FLNC	2591	Q14315
TGHVAGTRKTTPGFR	QPRT	131	Q15274
GKEPGGSRAHSSHLK	TP53	356	P04637
AGHRVRESGHKVPVS	PSRC1	321	Q6PGN9
KERGHHGASSSREPV	NYAP2	561	Q9P242
DSPLHRGVHGKTGQL	FOXA1	306	P55317
GPEGHRKTSSRSDHG	BICRAL	936	Q6AI39
KGLLRAHGTHPAIST	DOCK6	306	Q96HP0
HRRTGHGSSGTRKPQ	AXIN1	646	O15169
ASVHLPRIGHATKGF	CHD1L	836	Q86WJ1
RRHKHSSESPGRDKG	ABL1	876	P00519
GSHTLLGAVGEPHRR	CYP26C1	126	Q6V0L0
HGRPGKIHRSATDAD	GBF1	1326	Q92538
TLPKVHRTGAVSGHS	KLKB1	86	P03952
HSHKPDATGGRGLSR	SLC39A9	271	Q9NUM3
HGQTKTHRRPGAVAT	MRPL3	231	P09001
GEARTQHGGSHVSRK	MRPS23	136	Q9Y3D9
ALSQHPHSRKGGLIG	VAC14	61	Q08AM6
GAGTGSAKHRLHPVK	RAB11FIP1	1166	Q6WKZ4
VHVAITNRRGGGKPH	PLCL2	876	Q9UPR0
HLRPGSTAHAAAGKR	SLF2	26	Q8IX21
GGLHSSRPLKRGLSH	RITA1	186	Q96K30
GKGLHRGHTKLAFPS	SQSTM1	156	Q13501
SERAALERHGGHKTP	PRKAB1	6	Q9Y478
EAQGIHISRHTRPKG	C12orf42	186	Q96LP6
HQLGLGGKDVRHSSP	COL24A1	46	Q17RW2
FGHRGSKQLHRGKPV	PGBD2	276	Q6P3X8
VKHGRPGIGATHSSR	RPS15	126	P62841
HLSPGAAGSSRVKHQ	TRPS1	601	Q9UHF7
SQLRVHGGTHTGEKP	ZNF700	431	Q9H0M5
CGLTRHVRTHTGEKP	ZNF778	406	Q96MU6
APELRSHGRSHTGEK	ZNF668	96	Q96K58
ERTGGSPSVRHGSFH	SPEN	1256	Q96T58
HRHPVAQSTDGIRGK	SPSB4	76	Q96A44
PSGHEGAAPGHTRRK	PFAS	11	O15067
RHVGSRGGPSERSHA	THSD1	631	Q9NS62
SKLATHRLAHGGARP	ZNF575	76	Q86XF7
GVHVPLGGRKSHRRH	SLC4A10	51	Q6U841
SGTRLKHHGRQAPGL	SUGP2	706	Q8IX01
GLHHGKRVGPISAVA	TNXB	1846	P22105
ATGKHRRSLGAGYPH	TMEM40	81	Q8WWA1
KSGGRDHTGRIRVHG	MRPL2	81	Q5T653
APGTRRHFSTSRGGH	nan	16	Q5XG85
LGGRVKTLHPAVHAG	ATIC	61	P31939
KHGGRVRTFPHERGN	USB1	66	Q9BQ65
RTHSGGNKRRHPVTV	ZFYVE1	106	Q9HBF4
SHLARHRRVHTGGKP	ZNF347	666	Q96SE7
ALHGPSGVGKSHVGR	TOR4A	191	Q9NXH8
SGVGKSHVGRLLARH	TOR4A	196	Q9NXH8
GKPGSHLGTSTLQRH	ZBED6	161	P86452
RAAGHRSHKRKLSGP	nan	241	Q8N9G6
GDGGRPTFVKNHRVH	ZNF547	136	Q8IVP9
GSNSFTVHPRGLHRG	TPRN	201	Q4KMQ1
LLGHPKTRAFITHGG	UGT2B10	361	P36537
AKKVRRVPGSSGHLH	STK39	361	Q9UEW8
HIQRLHSPDGRKSGT	ZNF335	1121	Q9H4Z2
SNLRRHGRTHTGEKP	ZNF433	631	Q8N7K0
HLTEKKRGAGGHGRT	THAP4	86	Q8WY91
GSLAIHRRAHTGEKP	ZNF785	241	A8K8V0
RGHARTVGHQASPIK	NLRP12	181	P59046