Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA polymerase II CTD heptapeptide repeat kinase activity

CDK12 CDK13

2.05e-0510142GO:0008353
GeneOntologyMolecularFunctionRNA polymerase II CTD heptapeptide repeat modifying activity

CDK12 CDK13

1.15e-0423142GO:0140994
GeneOntologyMolecularFunctioncyclin-dependent protein serine/threonine kinase activity

CDK12 CDK13

1.96e-0430142GO:0004693
GeneOntologyMolecularFunctioncyclin-dependent protein kinase activity

CDK12 CDK13

1.96e-0430142GO:0097472
GeneOntologyMolecularFunctioncyclin binding

CDK12 CDK13

2.68e-0435142GO:0030332
GeneOntologyMolecularFunctionprotein kinase activity

CDK12 CDK13 WNK2 CHKA

6.35e-04600144GO:0004672
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

CDK12 CDK13 WNK2 CHKA

1.19e-03709144GO:0016773
GeneOntologyMolecularFunctionkinase activity

CDK12 CDK13 WNK2 CHKA

1.57e-03764144GO:0016301
GeneOntologyMolecularFunctionprotein serine kinase activity

CDK12 CDK13 WNK2

1.87e-03363143GO:0106310
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

CDK12 CDK13 WNK2 CHKA

3.32e-03938144GO:0016772
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

CDK12 CDK13 WNK2

3.35e-03446143GO:0004674
GeneOntologyMolecularFunctionkinase binding

CDK12 CDK13 HTT STRIP1

3.73e-03969144GO:0019900
GeneOntologyCellularComponentcyclin/CDK positive transcription elongation factor complex

CDK12 CDK13

1.50e-059142GO:0008024
GeneOntologyCellularComponentnuclear cyclin-dependent protein kinase holoenzyme complex

CDK12 CDK13

6.33e-0518142GO:0019908
GeneOntologyCellularComponentcarboxy-terminal domain protein kinase complex

CDK12 CDK13

1.14e-0424142GO:0032806
GeneOntologyCellularComponenttranscription elongation factor complex

CDK12 CDK13

6.28e-0456142GO:0008023
GeneOntologyCellularComponentcyclin-dependent protein kinase holoenzyme complex

CDK12 CDK13

7.45e-0461142GO:0000307
GeneOntologyCellularComponentserine/threonine protein kinase complex

CDK12 CDK13

4.81e-03157142GO:1902554
GeneOntologyCellularComponentprotein kinase complex

CDK12 CDK13

5.61e-03170142GO:1902911
DomainKinase-like_dom

CDK12 CDK13 WNK2 CHKA

7.42e-04542154IPR011009
DomainSer/Thr_kinase_AS

CDK12 CDK13 WNK2

2.66e-03357153IPR008271
DomainS_TKc

CDK12 CDK13 WNK2

2.70e-03359153SM00220
DomainPROTEIN_KINASE_ST

CDK12 CDK13 WNK2

2.76e-03362153PS00108
DomainPkinase

CDK12 CDK13 WNK2

3.19e-03381153PF00069
DomainPROTEIN_KINASE_ATP

CDK12 CDK13 WNK2

5.38e-03459153PS00107
DomainProt_kinase_dom

CDK12 CDK13 WNK2

6.42e-03489153IPR000719
DomainPROTEIN_KINASE_DOM

CDK12 CDK13 WNK2

6.56e-03493153PS50011
DomainARM-like

MN1 HTT

1.93e-02270152IPR011989
Domain-

ZFHX2 RCOR2

2.11e-022831521.10.10.60
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_DNA_REPAIR_GENES

CDK12 CDK13

3.86e-044792MM15328
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_DNA_REPAIR_GENES

CDK12 CDK13

6.72e-046292M27618
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

CDK12 KMT2C CDK13 HTT

7.84e-03138794M734
Pubmed

Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing.

CDK12 CDK13

1.74e-07215225561469
Pubmed

Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.

CDK12 CDK13

1.74e-07215224999027
Pubmed

CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1.

CDK12 CDK13

1.74e-07215220952539
Pubmed

Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer.

CDK12 CDK13

1.74e-07215235857807
Pubmed

Human CDK12 and CDK13, multi-tasking CTD kinases for the new millenium.

CDK12 CDK13

1.74e-07215230319007
Pubmed

CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1.

CDK12 CDK13

5.21e-07315237026485
Pubmed

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.

CDK12 CDK13

1.04e-06415222012619
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

TULP4 ZFHX2 KMT2C CDK13 WNK2 HTT TSPYL2

1.24e-06148915728611215
Pubmed

Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells.

CDK12 CDK13

1.73e-06515222547058
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TULP4 CDK12 KMT2C CDK13 WNK2 HTT

3.97e-06110515635748872
Pubmed

Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

ZFHX2 WNK2 STRIP1

1.09e-0510215311214970
Pubmed

Cyclin-dependent kinases: a family portrait.

CDK12 CDK13

1.14e-051215219884882
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

TULP4 NYAP1 WNK2 TSPYL2

2.82e-0543015435044719
Pubmed

Combinatorial CRISPR screen identifies fitness effects of gene paralogues.

CDK12 CDK13 HTT

6.53e-0518615333637726
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

PCED1B KMT2C CDK13 HTT CHKA

1.75e-04132715532694731
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

MN1 CDK12 CDK13 STRIP1

2.73e-0477415415302935
GeneFamilyCyclin dependent kinases

CDK12 CDK13

5.54e-052682496
CoexpressionGSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_DN

TULP4 MN1 TSPYL2

1.58e-04189153M8275
CoexpressionGSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_8H_UP

CDK12 TSPYL2 CHKA

1.65e-04192153M8272
CoexpressionGSE17974_1.5H_VS_72H_IL4_AND_ANTI_IL12_ACT_CD4_TCELL_UP

CDK12 STRIP1 TSPYL2

1.81e-04198153M4247
CoexpressionGSE22886_NAIVE_CD4_TCELL_VS_12H_ACT_TH2_UP

ZFHX2 MN1 TSPYL2

1.83e-04199153M4526
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#4_top-relative-expression-ranked_1000

TULP4 CDK12 KMT2C CHKA

1.58e-06127154gudmap_developingGonad_e16.5_epididymis_1000_k4
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#3_top-relative-expression-ranked_1000

TULP4 KMT2C HTT CHKA

3.36e-05275154gudmap_developingGonad_e14.5_ epididymis_1000_k3
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_top-relative-expression-ranked_1000

TULP4 CDK12 KMT2C HTT CHKA

1.55e-04790155gudmap_developingGonad_e16.5_epididymis_1000
ToppCell(09)_Ionocytes-(3)_72hpi|(09)_Ionocytes / shred by cell type and Timepoint

ZFHX2 MN1 RCOR2

6.33e-06110153fce7d5a0617fc664b657f5bb9abb290e7cc234cb
ComputationalNeighborhood of ATM

CDK13 HTT

2.16e-042792GCM_ATM
Diseasetransient cerebral ischemia (biomarker_via_orthology)

WNK2 HTT CHKA

6.42e-05157153DOID:224 (biomarker_via_orthology)
DiseaseHypermetropia

TULP4 CDK12

1.23e-03103152HP_0000540
DiseaseIntellectual Disability

MN1 KMT2C HTT

1.37e-03447153C3714756
Diseaselipoprotein A measurement

TULP4 CHKA

1.45e-03112152EFO_0006925
DiseaseAcute Myeloid Leukemia, M1

MN1 KMT2C

1.80e-03125152C0026998
DiseaseAcute Myeloid Leukemia (AML-M2)

MN1 KMT2C

1.80e-03125152C1879321
Diseaseprostate cancer (is_marker_for)

KMT2C CDK13

2.79e-03156152DOID:10283 (is_marker_for)
DiseaseLeukemia, Myelocytic, Acute

MN1 KMT2C

3.41e-03173152C0023467
Diseaseforced expiratory volume

TULP4 MN1 CDK12

6.82e-03789153EFO_0004314
Diseaseplatelet crit

TULP4 MN1 CDK13

1.14e-02952153EFO_0007985

Protein segments in the cluster

PeptideGeneStartEntry
LPPLPPIPALPQQPP

CDK12

551

Q9NYV4
PIPALPQQPPLPPSQ

CDK12

556

Q9NYV4
LPLLQPQLLQPPPPP

CDK13

41

Q14004
PQLLQPPPPPPPLLF

CDK13

46

Q14004
LQPRLAPNQPPPPLI

RCOR2

476

Q8IZ40
TPLPQPPPPTQLLPI

KMT2C

1536

Q8NEZ4
PPQRLPLLPLLSPQP

PCED1B

306

Q96HM7
PLLPLLSPQPPPPIL

PCED1B

311

Q96HM7
LPQPPPQAQPLLPQP

HTT

51

P42858
LPPLPPLPPQPQFLP

DMRTB1

271

Q96MA1
QQPPLALPPPPPLPL

CHKA

51

P35790
QPHPALPLPLPLPPQ

NYAP1

756

Q6ZVC0
PPQQQPPPPPGLLVR

MN1

356

Q10571
LIVNNKQPQPPPPPP

STRIP1

11

Q5VSL9
IIQNPPPLSLPPPPQ

TULP4

766

Q9NRJ4
PPPLLRLPLPPPQQR

TSPYL2

31

Q9H2G4
LPNALLQPPPQPPEP

ZFHX2

2396

Q9C0A1
QPALPPQPTLPPQPV

WNK2

941

Q9Y3S1
LPPQPVLPPQPALPV

WNK2

986

Q9Y3S1