Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	histone pre-mRNA 3'end processing complex	LSM11 SYNCRIP	8.70e-05	6	51	2	GO:0071204
Domain	RRM_1	HNRNPDL RBM15B EWSR1 SYNCRIP	2.48e-03	208	51	4	PF00076
Domain	RRM	HNRNPDL RBM15B EWSR1 SYNCRIP	2.89e-03	217	51	4	SM00360
Domain	HMGI/Y_DNA-bd_CS	PPAN EWSR1	3.23e-03	31	51	2	IPR000637
Domain	RRM_dom	HNRNPDL RBM15B EWSR1 SYNCRIP	3.40e-03	227	51	4	IPR000504
Domain	RRM	HNRNPDL RBM15B EWSR1 SYNCRIP	3.56e-03	230	51	4	PS50102
Domain	-	HNRNPDL RBM15B EWSR1 SYNCRIP	4.39e-03	244	51	4	3.30.70.330
Domain	Nucleotide-bd_a/b_plait	HNRNPDL RBM15B EWSR1 SYNCRIP	5.34e-03	258	51	4	IPR012677
Domain	LamG	COL11A2 AGRN	6.43e-03	44	51	2	SM00282
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	HNRNPDL PPAN SERBP1 RRP36 UBAP2L ZC3H4 PRRC2C RRP9 DDX54 RBM15B EWSR1 RCC2 SYNCRIP	1.42e-10	807	52	13	22681889
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	ZNF787 HNRNPDL PPAN SERBP1 ZC3H4 LSG1 PRRC2C DDX54 RBM15B RCC2 SYNCRIP	7.01e-09	713	52	11	29802200
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	ZNF787 PPAN SERBP1 PCNX3 LSG1 PLEKHG3 RRP9 PIEZO1 RBM15B LSM11 INO80 AGRN RCC2 INO80B	2.68e-08	1497	52	14	31527615
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	HNRNPDL PPAN RRP36 UBAP2L ZC3H4 PLEKHG3 RRP9 DDX54 EWSR1 LASP1 RCC2 SYNCRIP	2.78e-08	1024	52	12	24711643
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	HNRNPDL PPAN SERBP1 LSG1 PLEKHG3 PRRC2C RRP9 FHOD1 DDX54 RBM15B EWSR1 RCC2 SYNCRIP	2.89e-08	1257	52	13	36526897
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	HNRNPDL PPAN SERBP1 ZC3H4 PRRC2C DDX54 EWSR1 RCC2 SYNCRIP	4.08e-08	486	52	9	30940648
Pubmed	The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.	HNRNPDL PPAN SERBP1 PRRC2C LSM11 SYNCRIP	8.92e-08	147	52	6	28977470
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	PPAN RRP36 ZC3H4 PRRC2C DDX54 RBM15B EWSR1 ADARB2 RCC2 SYNCRIP	1.13e-07	731	52	10	29298432
Pubmed	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	HNRNPDL SERBP1 UBAP2L PRRC2C EWSR1 LASP1 SYNCRIP	1.15e-07	258	52	7	37794589
Pubmed	Human transcription factor protein interaction networks.	PPAN ZNF608 UBAP2L PRRC2C DDX54 EWSR1 LASP1 INO80 MBD6 RFX5 RCC2 INO80B SYNCRIP	1.28e-07	1429	52	13	35140242
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	HNRNPDL SERBP1 UBAP2L ZC3H4 PRRC2C RBM15B EWSR1 RFX5 RCC2 INO80B SYNCRIP	1.35e-07	954	52	11	36373674
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	HNRNPDL PPAN SERBP1 UBAP2L PRRC2C RRP9 DDX54 RBM15B RCC2 SYNCRIP	1.60e-07	759	52	10	35915203
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	SHANK1 HNRNPDL R3HDM4 UBAP2L PRRC2C EWSR1 LSM11 SYNCRIP	4.12e-07	462	52	8	31138677
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	PPAN SERBP1 ZC3H4 LSG1 RRP9 DDX54 RBM15B EWSR1 INO80 INO80B	4.37e-07	847	52	10	35850772
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	HNRNPDL PPAN SERBP1 PRRC2C RRP9 DDX54 RBM15B EWSR1 LASP1	8.85e-07	701	52	9	30196744
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	HNRNPDL SERBP1 UBAP2L ZC3H4 LSG1 PRRC2C FHOD1 DDX54 EWSR1 LASP1 RCC2 SYNCRIP	8.95e-07	1415	52	12	28515276
Pubmed	Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication.	HNRNPDL SERBP1 DDX54 EWSR1 SYNCRIP	1.07e-06	121	52	5	34029587
Pubmed	Ki-1/57 interacts with PRMT1 and is a substrate for arginine methylation.	SERBP1 EWSR1 SYNCRIP	1.42e-06	15	52	3	16879614
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	HNRNPDL SERBP1 UBAP2L ZC3H4 PRRC2C EWSR1 LSM11 SYNCRIP	1.54e-06	551	52	8	34728620
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SERBP1 ZC3H4 PRRC2C DDX54 RBM15B RCC2	2.05e-06	251	52	6	31076518
Pubmed	Mechanosensitive cation currents through TRPC6 and Piezo1 channels in human pulmonary arterial endothelial cells.	PIEZO1 TRPC6	2.19e-06	2	52	2	35968892
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	HNRNPDL PPAN SERBP1 PRRC2C DDX54 RBM15B EWSR1 SYNCRIP	3.07e-06	605	52	8	28977666
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	PPAN SERBP1 UBAP2L PRRC2C CTDP1 EWSR1 RCC2 SYNCRIP	3.47e-06	615	52	8	31048545
Pubmed	Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.	UBAP2L LSG1 EWSR1 AGRN SYNCRIP	3.73e-06	156	52	5	29961565
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	HNRNPDL PPAN SERBP1 RRP9 DDX54	4.62e-06	163	52	5	22113938
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	ZNF469 PPAN ZC3H4 LSG1 DDX54 EWSR1 LASP1 RCC2	5.38e-06	653	52	8	33742100
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	SERBP1 UBAP2L PRRC2C RRP9 DDX54 EWSR1 RCC2 SYNCRIP	5.38e-06	653	52	8	22586326
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	SERBP1 UBAP2L ZC3H4 PRRC2C DDX54 EWSR1 RCC2 SYNCRIP	5.50e-06	655	52	8	35819319
Pubmed	Piezo1 agonist restores meningeal lymphatic vessels, drainage, and brain-CSF perfusion in craniosynostosis and aged mice.	PIEZO1 TWIST1	6.57e-06	3	52	2	37917195
Pubmed	PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.	HNRNPDL SERBP1 UBAP2L PRRC2C RRP9 DDX54 EWSR1 SYNCRIP	7.07e-06	678	52	8	30209976
Pubmed	The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.	HNRNPDL SERBP1 UBAP2L PRRC2C RCC2 SYNCRIP	9.83e-06	330	52	6	32529326
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	HNRNPDL SERBP1 UBAP2L RRP9 DDX54 EWSR1 RCC2 SYNCRIP	9.98e-06	711	52	8	33022573
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	ZNF787 SERBP1 RRP36 LSG1 PLEKHG3 DDX54 EWSR1 RCC2 SYNCRIP	1.04e-05	949	52	9	36574265
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	ZNF608 PCNX3 RRP36 ZC3H4 PLEKHG3 PIEZO1 FHOD1 LASP1 AGRN INO80B	1.09e-05	1215	52	10	15146197
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	HNRNPDL SERBP1 UBAP2L ZC3H4 LSG1 PRRC2C LASP1 INO80	1.14e-05	724	52	8	36232890
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SHANK1 FAM171A2 UBAP2L ZC3H4 LSG1 PRRC2C EWSR1 AGRN AGAP2	1.16e-05	963	52	9	28671696
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	HNRNPDL RRP9 DDX54 ING5 RBM15B EWSR1 INO80 RFX5 RCC2 SYNCRIP	1.87e-05	1294	52	10	30804502
Pubmed	Functional proteomic analysis of human nucleolus.	PPAN RRP9 DDX54 RCC2	1.97e-05	106	52	4	12429849
Pubmed	Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner.	SHANK1 SERBP1 ITPKA AGAP2 SYNCRIP	2.60e-05	233	52	5	29518331
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	HNRNPDL SERBP1 UBAP2L ZC3H4 PRRC2C EWSR1	2.86e-05	399	52	6	35987950
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	ZNF787 ZC3H4 LSG1 RBM15B EWSR1 INO80 AGRN RCC2 SYNCRIP	2.92e-05	1082	52	9	38697112
Pubmed	SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.	PPAN SERBP1 UBAP2L DDX54 SYNCRIP	3.30e-05	245	52	5	35652658
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PCNX3 PIEZO1 CTDP1 INO80 MBD6 TMEM127 ADGRA2 AGRN ANO8	3.44e-05	1105	52	9	35748872
Pubmed	The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.	PPAN SERBP1 RRP9 DDX54 EWSR1 SYNCRIP	3.66e-05	417	52	6	36537216
Pubmed	Nucleolar proteome dynamics.	RRP36 RRP9 DDX54 EWSR1 ADARB2 SYNCRIP	3.76e-05	419	52	6	15635413
Pubmed	The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.	PPAN SERBP1 PRRC2C DDX54 SYNCRIP	3.85e-05	253	52	5	29911972
Pubmed	Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.	HNRNPDL SERBP1 UBAP2L EWSR1 RCC2 SYNCRIP	3.86e-05	421	52	6	34650049
Pubmed	RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.	HNRNPDL PPAN SERBP1 DDX54 RCC2 SYNCRIP	4.07e-05	425	52	6	21081503
Pubmed	Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop.	HNRNPDL SERBP1 UBAP2L EWSR1 SYNCRIP	4.38e-05	260	52	5	36199071
Pubmed	The N-terminal domain of the Schaaf-Yang syndrome protein MAGEL2 likely has a role in RNA metabolism.	SERBP1 UBAP2L PRRC2C	4.57e-05	46	52	3	34265304
Pubmed	Three proteins of the U7-specific Sm ring function as the molecular ruler to determine the site of 3'-end processing in mammalian histone pre-mRNA.	LSM11 SYNCRIP	6.10e-05	8	52	2	19470752
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	SERBP1 UBAP2L ZC3H4 LSG1 PRRC2C FHOD1 LASP1 RCC2	6.94e-05	934	52	8	33916271
Pubmed	Analysis of HIV-1 Gag protein interactions via biotin ligase tagging.	SERBP1 UBAP2L PRRC2C	7.41e-05	54	52	3	25631074
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	UBAP2L LSG1 PRRC2C INO80 RCC2 SYNCRIP	7.52e-05	475	52	6	31040226
Pubmed	Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases.	SERBP1 PRRC2C EWSR1 LASP1 SYNCRIP	7.96e-05	295	52	5	26209609
Pubmed	The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.	PPAN RRP36 UBAP2L PRRC2C RRP9 DDX54	8.24e-05	483	52	6	36912080
Pubmed	Proteomic analysis of the cullin 4B interactome using proximity-dependent biotinylation in living cells.	HNRNPDL PPAN EWSR1 RCC2	8.27e-05	153	52	4	28225217
Pubmed	RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.	SERBP1 UBAP2L ZC3H4 RCC2	8.92e-05	156	52	4	26170170
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	HNRNPDL SERBP1 UBAP2L ZC3H4 PRRC2C DDX54 RCC2 SYNCRIP	9.09e-05	971	52	8	33306668
Pubmed	TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules.	SERBP1 EWSR1	9.79e-05	10	52	2	18632687
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	HNRNPDL ZC3H4 LSG1 RRP9 DDX54 EWSR1 LASP1 SYNCRIP	1.03e-04	989	52	8	36424410
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	HNRNPDL SERBP1 UBAP2L DDX54 RCC2 BRWD3 ANO8 SYNCRIP	1.28e-04	1021	52	8	26760575
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZNF608 ZC3H4 PIEZO1 INO80 ADGRA2 RCC2	1.35e-04	529	52	6	14621295
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	HNRNPDL PPAN UBAP2L ZC3H4 FHOD1 CTDP1 RBM15B	1.47e-04	774	52	7	15302935
Pubmed	Inactivation of fibroblast growth factor binding protein 3 causes anxiety-related behaviors.	FGFBP3 FOXO4	1.69e-04	13	52	2	20851768
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	HNRNPDL RBM15B EWSR1 ADARB2 SYNCRIP	1.70e-04	347	52	5	16033648
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	PPAN SERBP1 DDX54 AGRN RCC2	1.75e-04	349	52	5	25665578
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	SERBP1 UBAP2L LSG1 PRRC2C LASP1 ANO8	1.99e-04	568	52	6	37774976
Pubmed	Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.	HNRNPDL PPAN RCC2	2.22e-04	78	52	3	28611094
Pubmed	The mammalian INO80 chromatin remodeling complex is required for replication stress recovery.	INO80 INO80B	2.27e-04	15	52	2	25016522
Pubmed	INO80 is required for oncogenic transcription and tumor growth in non-small cell lung cancer.	INO80 INO80B	2.27e-04	15	52	2	27641337
Pubmed	Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling.	INO80 INO80B	2.27e-04	15	52	2	21303910
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF469 ZNF608 ZC3H4 LSG1 ING5 INO80 BRWD3 INO80B	2.36e-04	1116	52	8	31753913
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	HNRNPDL SERBP1 UBAP2L LSG1 RRP9 DDX54 RBM15B RCC2 SYNCRIP	2.38e-04	1425	52	9	30948266
Pubmed	Profiling of Parkin-binding partners using tandem affinity purification.	HNRNPDL SERBP1 PRRC2C SYNCRIP	2.45e-04	203	52	4	24244333
Pubmed	The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins.	SERBP1 UBAP2L PRRC2C RCC2	2.45e-04	203	52	4	35012549
Pubmed	Interactomic analysis of REST/NRSF and implications of its functional links with the transcription suppressor TRIM28 during neuronal differentiation.	SERBP1 DDX54 EWSR1 SYNCRIP	2.54e-04	205	52	4	27976729
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	PPAN SERBP1 UBAP2L PLEKHG3 PRRC2C DDX54 ING5 RCC2 SYNCRIP	2.57e-04	1440	52	9	30833792
Pubmed	Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production.	HNRNPDL PPAN EWSR1 SYNCRIP	2.59e-04	206	52	4	22174317
Pubmed	The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability.	INO80 INO80B	2.60e-04	16	52	2	23979016
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	SHANK1 SERBP1 FAM171A2 UBAP2L PRRC2C LASP1 ANO8 AGAP2	2.70e-04	1139	52	8	36417873
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	HNRNPDL SERBP1 UBAP2L ZC3H4 PRRC2C EWSR1 RCC2 SYNCRIP	2.87e-04	1149	52	8	35446349
Pubmed	The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes.	SERBP1 EWSR1 LASP1 SYNCRIP	2.89e-04	212	52	4	23463506
Pubmed	Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest and Abnormal Chromosome Stability.	INO80 INO80B	2.94e-04	17	52	2	26340092
Pubmed	Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.	HNRNPDL AGRN RCC2 SYNCRIP	3.27e-04	219	52	4	31353912
Pubmed	YY1 functions with INO80 to activate transcription.	INO80 INO80B	3.30e-04	18	52	2	17721549
Pubmed	Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6.	ZNF787 HNRNPDL SYNCRIP	3.38e-04	90	52	3	23151878
Pubmed	Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.	HNRNPDL SERBP1 PRRC2C SYNCRIP	3.50e-04	223	52	4	20020773
Pubmed	A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex.	INO80 INO80B	3.69e-04	19	52	2	16230350
Pubmed	CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.	SERBP1 UBAP2L PRRC2C RCC2 SYNCRIP	4.00e-04	418	52	5	35338135
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	ZC3H4 LSG1 PRRC2C EWSR1 AGRN RCC2	4.08e-04	650	52	6	38777146
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	SERBP1 CTDP1 DDX54 RCC2	4.20e-04	234	52	4	36243803
Pubmed	The RNA-binding protein Snd1/Tudor-SN regulates hypoxia-responsive gene expression.	SERBP1 UBAP2L PRRC2C	4.21e-04	97	52	3	37151849
Pubmed	Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy.	HNRNPDL UBAP2L EWSR1	4.47e-04	99	52	3	31723608
Pubmed	OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer.	SERBP1 RCC2	4.52e-04	21	52	2	30662561
Pubmed	TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.	HNRNPDL LSG1 RRP9 EWSR1 SYNCRIP	4.55e-04	430	52	5	38172120
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	HNRNPDL RRP9 EWSR1 SYNCRIP	4.91e-04	244	52	4	29884807
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	PPAN SERBP1 ZNF608 DDX54 EWSR1 LASP1 RCC2 SYNCRIP	4.94e-04	1247	52	8	27684187
Pubmed	Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS.	UBAP2L DDX54 EWSR1 SYNCRIP	4.99e-04	245	52	4	21182205
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	PPAN UBAP2L LSG1 RRP9 DDX54	5.05e-04	440	52	5	34244565
Interaction	SNRNP70 interactions	ZNF787 HNRNPDL PPAN SERBP1 ZC3H4 LSG1 PLEKHG3 PRRC2C CTDP1 DDX54 RBM15B EWSR1 RCC2 SYNCRIP	9.50e-08	984	51	14	int:SNRNP70
Interaction	WDR5 interactions	HNRNPDL SERBP1 ZNF608 UBAP2L PRRC2C RRP9 DDX54 EWSR1 INO80 MBD6 RCC2 INO80B TWIST1 SYNCRIP	3.75e-07	1101	51	14	int:WDR5
Interaction	HBP1 interactions	DCAF15 PPAN SERBP1 DDX54 EWSR1 SYNCRIP	6.58e-07	123	51	6	int:HBP1
Interaction	MYCN interactions	ZNF787 HNRNPDL PPAN SERBP1 RRP36 UBAP2L ZC3H4 PRRC2C RRP9 DDX54 RBM15B EWSR1 RCC2 INO80B SYNCRIP	9.03e-07	1373	51	15	int:MYCN
Interaction	BRD7 interactions	HNRNPDL PPAN SERBP1 ZC3H4 PRRC2C DDX54 EWSR1 RCC2 TWIST1 SYNCRIP	3.68e-06	637	51	10	int:BRD7
Interaction	RC3H1 interactions	HNRNPDL SERBP1 UBAP2L ZC3H4 PRRC2C RRP9 DDX54 EWSR1 RCC2 SYNCRIP	6.30e-06	677	51	10	int:RC3H1
Interaction	PRMT8 interactions	SERBP1 PRRC2C EWSR1 AGAP2 SYNCRIP	6.46e-06	104	51	5	int:PRMT8
Interaction	UQCR11 interactions	RRP36 ZC3H4 LSG1 RBM15B	9.72e-06	53	51	4	int:UQCR11
Interaction	CSNK2A2 interactions	PPAN SERBP1 HAGHL ZC3H4 PRRC2C CTDP1 DDX54 RCC2 BRWD3 AGAP2	1.05e-05	718	51	10	int:CSNK2A2
Interaction	CFAP141 interactions	RRP36 ZC3H4 LSG1 RBM15B	1.13e-05	55	51	4	int:CFAP141
Interaction	CUL4B interactions	HNRNPDL DCAF15 PPAN SERBP1 PRRC2C EWSR1 RCC2 BRWD3 TWIST1 SYNCRIP	1.19e-05	728	51	10	int:CUL4B
Interaction	OBSL1 interactions	HNRNPDL PPAN RRP36 UBAP2L ZC3H4 RRP9 DDX54 EWSR1 RCC2 TWIST1 SYNCRIP	1.25e-05	902	51	11	int:OBSL1
Interaction	AURKB interactions	PPAN SERBP1 ZC3H4 PLEKHG3 PRRC2C CTDP1 DDX54 MBD6 RCC2 SYNCRIP	1.74e-05	761	51	10	int:AURKB
Interaction	CSNK2A1 interactions	HNRNPDL PPAN SERBP1 HAGHL ZC3H4 PRRC2C RRP9 CTDP1 DDX54 RCC2 BRWD3	2.15e-05	956	51	11	int:CSNK2A1
Interaction	DOT1L interactions	PPAN SERBP1 ZC3H4 LSG1 RRP9 DDX54 RBM15B INO80 INO80B SYNCRIP	2.88e-05	807	51	10	int:DOT1L
Interaction	SMC5 interactions	HNRNPDL SERBP1 UBAP2L ZC3H4 PRRC2C RBM15B EWSR1 RFX5 RCC2 INO80B SYNCRIP	3.25e-05	1000	51	11	int:SMC5
Interaction	WDR77 interactions	HNRNPDL PPAN SERBP1 PRRC2C CTDP1 LSM11 SYNCRIP	3.28e-05	361	51	7	int:WDR77
Interaction	WWP2 interactions	PPAN SERBP1 UBAP2L GGN PRRC2C CTDP1 EWSR1 TMEM127 RCC2 SYNCRIP	4.05e-05	840	51	10	int:WWP2
Interaction	FHOD1 interactions	DCAF15 SERBP1 FHOD1 CTDP1	4.99e-05	80	51	4	int:FHOD1
Interaction	DDRGK1 interactions	ZNF787 HNRNPDL PPAN SERBP1 LSG1 PRRC2C RRP9 GJD3 DDX54 EWSR1 RCC2 SYNCRIP	5.06e-05	1249	51	12	int:DDRGK1
Interaction	PSENEN interactions	RRP36 ZC3H4 LSG1 RBM15B	5.24e-05	81	51	4	int:PSENEN
Interaction	PRRC2A interactions	SERBP1 UBAP2L PRRC2C CTDP1 DDX54 EWSR1 SYNCRIP	5.27e-05	389	51	7	int:PRRC2A
Interaction	ZC3H18 interactions	PPAN RRP36 ZC3H4 PRRC2C DDX54 RBM15B EWSR1 ADARB2 RCC2 SYNCRIP	5.83e-05	877	51	10	int:ZC3H18
Interaction	SELENOI interactions	SERBP1 TRPC6 EWSR1	5.91e-05	30	51	3	int:SELENOI
Interaction	CDV3 interactions	SERBP1 UBAP2L EWSR1 RFX5	6.63e-05	86	51	4	int:CDV3
Interaction	CELF1 interactions	HNRNPDL UBAP2L ZC3H4 PRRC2C EWSR1 SYNCRIP	8.48e-05	288	51	6	int:CELF1
Interaction	LINC02910 interactions	RRP36 ZC3H4 LSG1 RBM15B	9.77e-05	95	51	4	int:LINC02910
Interaction	ALG13 interactions	SERBP1 ZNF608 UBAP2L PRRC2C SYNCRIP	9.79e-05	183	51	5	int:ALG13
Interaction	YTHDF1 interactions	SERBP1 UBAP2L PRRC2C LASP1 TWIST1 SYNCRIP	1.10e-04	302	51	6	int:YTHDF1
Interaction	FLNB interactions	HNRNPDL DCAF15 SERBP1 ZC3H4 PRRC2C AGRN	1.14e-04	304	51	6	int:FLNB
Interaction	TMSB4Y interactions	RRP36 RBM15B EWSR1	1.31e-04	39	51	3	int:TMSB4Y
Interaction	HECTD1 interactions	HNRNPDL PPAN SERBP1 UBAP2L PRRC2C RRP9 DDX54 RBM15B RCC2 SYNCRIP	1.51e-04	984	51	10	int:HECTD1
Interaction	EP300 interactions	HNRNPDL ZNF469 PPAN ZC3H4 LSG1 CTDP1 DDX54 ING5 EWSR1 LASP1 RCC2 TWIST1	1.52e-04	1401	51	12	int:EP300
Interaction	ZNF469 interactions	ZNF469 BRWD3	1.74e-04	8	51	2	int:ZNF469
Interaction	RBMS1 interactions	SERBP1 UBAP2L PRRC2C RFX5 SYNCRIP	1.74e-04	207	51	5	int:RBMS1
Interaction	FBL interactions	SERBP1 RRP36 UBAP2L LSG1 PRRC2C RRP9 DDX54 SYNCRIP	1.87e-04	639	51	8	int:FBL
Interaction	TDRD3 interactions	SERBP1 UBAP2L PRRC2C EWSR1 SYNCRIP	1.95e-04	212	51	5	int:TDRD3
Interaction	EFTUD2 interactions	HNRNPDL SERBP1 UBAP2L ZC3H4 LSG1 PRRC2C FHOD1 DDX54 EWSR1 LASP1 RCC2 SYNCRIP	2.08e-04	1449	51	12	int:EFTUD2
Interaction	SPTAN1 interactions	SHANK1 SERBP1 GJD3 EWSR1 LASP1 AGRN AGAP2	2.38e-04	496	51	7	int:SPTAN1
Interaction	RC3H2 interactions	HNRNPDL SERBP1 UBAP2L PRRC2C RRP9 DDX54 EWSR1 SYNCRIP	2.50e-04	667	51	8	int:RC3H2
Interaction	CDK12 interactions	DCAF15 SERBP1 HAGHL EWSR1 LASP1	2.73e-04	228	51	5	int:CDK12
Interaction	KAT6A interactions	PPAN SERBP1 RRP9 DDX54 ING5 EWSR1 SYNCRIP	2.82e-04	510	51	7	int:KAT6A
Interaction	TXN interactions	HNRNPDL SERBP1 PRRC2C EWSR1 MBD6 SYNCRIP	2.85e-04	360	51	6	int:TXN
Interaction	CDK9 interactions	SERBP1 PRRC2C CTDP1 ING5 RBM15B EWSR1 LASP1 SYNCRIP	2.99e-04	685	51	8	int:CDK9
Interaction	ANAPC15 interactions	RRP36 ZC3H4 LSG1 RBM15B	3.08e-04	128	51	4	int:ANAPC15
Interaction	KHDRBS2 interactions	HNRNPDL SERBP1 EWSR1 SYNCRIP	3.17e-04	129	51	4	int:KHDRBS2
Interaction	RNF113A interactions	SERBP1 UBAP2L ZC3H4 PRRC2C DDX54 EWSR1 RCC2 SYNCRIP	3.20e-04	692	51	8	int:RNF113A
Interaction	MED15 interactions	UBAP2L CTDP1 EWSR1 INO80	3.36e-04	131	51	4	int:MED15
Interaction	RGS14 interactions	SHANK1 SERBP1 ITPKA AGAP2 SYNCRIP	3.45e-04	240	51	5	int:RGS14
Interaction	SAA1 interactions	RRP36 ZC3H4 PLEKHG3	3.46e-04	54	51	3	int:SAA1
Interaction	RACK1 interactions	DCAF15 PPAN SERBP1 GGN PRRC2C DDX54 INO80 SYNCRIP	3.59e-04	704	51	8	int:RACK1
Interaction	JPH3 interactions	RRP36 PLEKHG3 RBM15B	3.65e-04	55	51	3	int:JPH3
Interaction	SRP19 interactions	SERBP1 RRP36 LSG1 PRRC2C DDX54	3.72e-04	244	51	5	int:SRP19
Interaction	FMR1 interactions	SERBP1 FAM171A2 UBAP2L PRRC2C EWSR1 AGAP2 SYNCRIP	3.80e-04	536	51	7	int:FMR1
Interaction	SRP68 interactions	DCAF15 PPAN SERBP1 LSG1 PRRC2C DDX54	3.85e-04	381	51	6	int:SRP68
Interaction	TNIK interactions	SHANK1 ZC3H4 LSG1 EWSR1 AGRN AGAP2	3.85e-04	381	51	6	int:TNIK
Interaction	ACE2 interactions	SHANK1 HNRNPDL SERBP1 UBAP2L PRRC2C RRP9 DDX54 EWSR1 LASP1 AGRN	3.88e-04	1106	51	10	int:ACE2
Interaction	ZFP41 interactions	ZC3H4 PRRC2C AGRN	4.06e-04	57	51	3	int:ZFP41
Interaction	GNL2 interactions	PPAN SERBP1 LSG1 RBM15B INO80B TWIST1	4.13e-04	386	51	6	int:GNL2
Interaction	IL7R interactions	ZNF787 HNRNPDL FAM171A2 SYNCRIP	4.45e-04	141	51	4	int:IL7R
Interaction	MAB21L2 interactions	SERBP1 UBAP2L PRRC2C SYNCRIP	4.69e-04	143	51	4	int:MAB21L2
Interaction	AIF1 interactions	RRP36 ZC3H4	4.81e-04	13	51	2	int:AIF1
Interaction	ZNF394 interactions	DDX54 AGRN	4.81e-04	13	51	2	int:ZNF394
Interaction	DAZL interactions	HNRNPDL UBAP2L PRRC2C SYNCRIP	4.94e-04	145	51	4	int:DAZL
Interaction	ETS2 interactions	CTDP1 EWSR1 TWIST1	4.95e-04	61	51	3	int:ETS2
Interaction	MAGEL2 interactions	SERBP1 UBAP2L PRRC2C	4.95e-04	61	51	3	int:MAGEL2
Interaction	CHD4 interactions	HNRNPDL PPAN SERBP1 PRRC2C DDX54 RBM15B EWSR1 TWIST1 SYNCRIP	5.15e-04	938	51	9	int:CHD4
Interaction	SIRT7 interactions	SERBP1 UBAP2L PRRC2C RRP9 DDX54 EWSR1 RCC2 SYNCRIP	5.19e-04	744	51	8	int:SIRT7
Interaction	TLN1 interactions	HNRNPDL DCAF15 SERBP1 PRRC2C SYNCRIP	5.33e-04	264	51	5	int:TLN1
Interaction	ATG16L1 interactions	HNRNPDL PPAN SERBP1 PLEKHG3 PRRC2C RRP9 DDX54 RBM15B EWSR1 LASP1	5.68e-04	1161	51	10	int:ATG16L1
Interaction	HMGN3 interactions	ZC3H4 PLEKHG3 PRRC2C	5.71e-04	64	51	3	int:HMGN3
Interaction	ZNF768 interactions	ZNF787 SERBP1 EWSR1 INO80B	5.76e-04	151	51	4	int:ZNF768
Interaction	IFI27L1 interactions	RRP36 ZC3H4 RBM15B	5.97e-04	65	51	3	int:IFI27L1
Interaction	REST interactions	SERBP1 DDX54 EWSR1 AGRN SYNCRIP	6.31e-04	274	51	5	int:REST
Interaction	RRP15 interactions	PPAN DDX54 EWSR1 SYNCRIP	6.66e-04	157	51	4	int:RRP15
Interaction	CNTNAP2 interactions	SHANK1 FAM171A2 UBAP2L AGAP2	6.82e-04	158	51	4	int:CNTNAP2
Interaction	DDX17 interactions	HNRNPDL LSG1 EWSR1 MBD6 INO80B SYNCRIP	6.94e-04	426	51	6	int:DDX17
Interaction	FXR2 interactions	SERBP1 UBAP2L PRRC2C DDX54 EWSR1 LASP1	7.29e-04	430	51	6	int:FXR2
Interaction	PCLO interactions	SERBP1 EWSR1 AGAP2	7.42e-04	70	51	3	int:PCLO
Interaction	PRRC2C interactions	HNRNPDL SERBP1 UBAP2L PRRC2C SYNCRIP	8.15e-04	290	51	5	int:PRRC2C
Interaction	MAP2K1 interactions	HNRNPDL SERBP1 RRP9 ING5 AGAP2	8.53e-04	293	51	5	int:MAP2K1
Interaction	AHCY interactions	HNRNPDL SERBP1 PRRC2C EWSR1 RCC2	8.53e-04	293	51	5	int:AHCY
Interaction	HCFC1 interactions	HNRNPDL ZNF608 UBAP2L PRRC2C MBD6	8.53e-04	293	51	5	int:HCFC1
Interaction	VIM interactions	HNRNPDL SERBP1 RRP9 ING5 LASP1 AGRN RCC2 TWIST1	8.62e-04	804	51	8	int:VIM
Cytoband	3p21.2	RRP9 RBM15B	2.13e-04	19	52	2	3p21.2
Cytoband	15q15.1	INO80 ITPKA	1.32e-03	47	52	2	15q15.1
GeneFamily	INO80 complex \|SRCAP complex	INO80 INO80B	3.14e-04	15	32	2	595
GeneFamily	RNA binding motif containing	HNRNPDL RBM15B EWSR1 SYNCRIP	5.20e-04	213	32	4	725
Coexpression	LIAO_METASTASIS	COL11A2 PCNX3 UBAP2L LASP1 AGRN RCC2 TWIST1 SYNCRIP	9.00e-06	540	51	8	M13809
Coexpression	KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN	HNRNPDL PPAN SERBP1 UBAP2L FGFBP3 RRP9 DDX54 EWSR1 TWIST1 SYNCRIP	1.24e-05	950	51	10	M19907
Coexpression	KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN	HNRNPDL PPAN SERBP1 UBAP2L PRRC2C FGFBP3 RRP9 DDX54 EWSR1 SYNCRIP	2.80e-05	1045	51	10	M8525
Coexpression	MARTENS_TRETINOIN_RESPONSE_DN	HNRNPDL SERBP1 HAGHL FGFBP3 GJD3 RBM15B FOXO4 ADGRA2 ITPKA	3.08e-05	839	51	9	M2099
Coexpression	SANSOM_APC_TARGETS_REQUIRE_MYC	PPAN HAGHL RRP9 FHOD1 RCC2	7.59e-05	225	51	5	M1757
Coexpression	SANSOM_APC_TARGETS_REQUIRE_MYC	PPAN HAGHL RRP9 FHOD1 RCC2	8.60e-05	231	51	5	MM737
Disease	Connective Tissue Diseases	ZNF469 COL11A2	2.26e-04	13	51	2	C0009782
Disease	progranulin measurement	FAM171A2 LSG1	6.62e-04	22	51	2	EFO_0004625
Disease	angina pectoris	PCNX3 BRWD3 TWIST1	1.33e-03	125	51	3	EFO_0003913
Disease	aspirin use measurement	PCNX3 TWIST1	2.08e-03	39	51	2	EFO_0007013
Disease	adverse effect, response to xenobiotic stimulus	CTDP1 ADARB2	4.71e-03	59	51	2	EFO_0009658, GO_0009410

Protein segments in the cluster

Peptide	Gene	Start	Entry
NRSMSGPDNRGRGRG	EWSR1	291	Q01844
ERSAAGGRGPRGHKR	CTDP1	906	Q9Y5B0
SRPGAAGPGKRRGVA	ADGRA2	661	Q96PE1
RNGRKGALRVGDGPR	AGRN	1731	O00468
RGGRGASRGATRAKR	BRWD3	1711	Q6RI45
PGLKRGREGGRASTR	AGAP2	326	Q99490
KVSFAERGAGRRRPG	ANO8	616	Q9HCE9
GRSKARRRGPGRGED	R3HDM4	141	Q96D70
SGNGTARAGPRKRGG	RCC2	16	Q9P258
ARARDKPRGSGSGGG	RBM15B	51	Q8NDT2
RGRPRKKSGGSGERN	RFX5	466	P48382
GDRARGGAPGAKRKR	ADARB2	86	Q9NS39
ARPLSRRGKRVGGEG	HAGHL	201	Q6PII5
AAGRGHSARSRGRPK	INO80	1421	Q9ULG1
PSRLAGGAAIKGGRR	HNRNPDL	66	O14979
GGAAIKGGRRRRPDL	HNRNPDL	71	O14979
RGRGGRPNRGSRTDK	SERBP1	376	Q8NC51
GFAGESKPRARNRGR	FGFBP3	161	Q8TAT2
PELLTGRGSGKRGRR	MBD6	846	Q96DN6
AAGAGRRGPGRSRKA	LSM11	126	P83369
MGRRRAPAGGSLGRA	LSG1	1	Q9H089
RTGGQRKGASLARPG	LINC02872	26	A2RU37
RKGASLARPGRGGLA	LINC02872	31	A2RU37
QRSAPGGGGKRYRAV	LASP1	196	Q14847
GASDRRGPERRGGKR	DDX54	786	Q8TDD1
RGGKRDRGQGASRPH	DDX54	796	Q8TDD1
RGARGAAPSRGRGAA	SYNCRIP	501	O60506
ARAKARGGGRGGRRN	FAM104A	31	Q969W3
ESSRGAAGGPRKRRA	PCNX3	456	Q9H6A9
GAVTGPRKGGSRRNA	FOXO4	86	P98177
GARGLSGKSGPRGER	COL11A2	826	P13942
RGQRGPRGATGKSGA	COL11A2	846	P13942
GGIGAPRRRAAALSG	GGN	371	Q86UU5
GARGERRGGRAAAPA	INO80B	256	Q9C086
AGEPRARGAKRRGGQ	ITPKA	51	P23677
GRAATVPRGRGRSRG	FAM171A2	761	A8MVW0
CGSGRGKASPATGRR	GJD3	276	Q8N144
GRGQKEKRGSRGRGR	ING5	131	Q8WYH8
GKRSRRSLEGGGCPA	FHOD1	361	Q9Y613
GGAGGKRAAGRRREH	DCAF15	21	Q66K64
GRCRSLSTKRGRGGG	PLEKHG3	1096	A1L390
KGEPTRRGRGGTFRR	PRRC2C	1336	Q9Y520
MARAGARGLLGGRRP	SHISA8	1	B8ZZ34
GGRQEAAGSRGRRAP	TRPT1	6	Q86TN4
GPGGSLGSRGRRRKL	SHANK1	536	Q9Y566
KSGGPSGRGTERGRR	UBAP2L	161	Q14157
GAGAGAGAGKRRRKA	RRP9	16	O43818
AQARRGPRGASRDGG	PPAN	446	Q9NQ55
YRAGAGAGAGARRPR	RRP36	6	Q96EU6
GAGAGARRPRGARDR	RRP36	11	Q96EU6
SLAKAGSNRRGPGRA	UNQ9370/PRO34162	46	Q6UXP9
RGRRRRQGGAGSAVK	nan	106	Q8N1X5
KEGSSRGRGSRGRGR	ZC3H4	231	Q9UPT8
GRAQGRGRPAKGRRA	ZNF469	3071	Q96JG9
GRGRGKRARSAAAAP	ZNF608	431	Q9ULD9
NGKGRRGSLNASGRR	ZNF608	466	Q9ULD9
KRPSRSGGRVRAAGR	PIEZO1	1911	Q92508
RGSSPRGAAGAAARR	TRPC6	11	Q9Y210
GRKRRSSRRSAGGGA	TWIST1	36	Q15672
GGRRRRSPGGSALPK	TMEM127	11	O75204
GAGAKAAGPRSRRAP	ZNF787	261	Q6DD87