Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionintracellularly calcium-gated chloride channel activity

ANO5 ANO6

3.81e-0420292GO:0005229
GeneOntologyMolecularFunctionintracellularly calcium-gated channel activity

ANO5 ANO6

3.81e-0420292GO:0141147
GeneOntologyMolecularFunctionphospholipid scramblase activity

ANO5 ANO6

5.06e-0423292GO:0017128
GeneOntologyMolecularFunctionligand-gated monoatomic anion channel activity

ANO5 ANO6

2.39e-0350292GO:0099095
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ANO5 ANO6

2.48e-0351292GO:0140303
Domain-

GTF2IRD2 GTF2IRD2B

1.39e-0542923.90.1460.10
DomainGTF2I

GTF2IRD2 GTF2IRD2B

1.39e-054292IPR004212
DomainGTF2I

GTF2IRD2 GTF2IRD2B

1.39e-054292PS51139
DomainGTF2I

GTF2IRD2 GTF2IRD2B

1.39e-054292PF02946
DomainAnoct_dimer

ANO5 ANO6

4.87e-057292PF16178
DomainAnoct_dimer

ANO5 ANO6

4.87e-057292IPR032394
DomainAnoctamin

ANO5 ANO6

1.04e-0410292PF04547
DomainAnoctamin

ANO5 ANO6

1.04e-0410292IPR007632
DomainRNaseH-like_dom

GTF2IRD2 GTF2IRD2B

5.12e-0369292IPR012337
DomainZnf_C2H2-like

GTF2IRD2 RLF ZNF214 GTF2IRD2B ZNF473

7.04e-03796295IPR015880
DomainZnF_C2H2

GTF2IRD2 RLF ZNF214 GTF2IRD2B ZNF473

7.49e-03808295SM00355
PathwayREACTOME_INDUCTION_OF_CELL_CELL_FUSION

ANO5 ANO6

1.19e-0413182M46426
Pubmed

Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.

GTF2IRD2 GTF2IRD2B

6.71e-07229215388857
Pubmed

Isolation and characterisation of GTF2IRD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams-Beuren syndrome.

GTF2IRD2 GTF2IRD2B

2.01e-06329215100712
Pubmed

Haploinsufficiency of Gtf2i, a gene deleted in Williams Syndrome, leads to increases in social interactions.

GTF2IRD2 GTF2IRD2B

4.02e-06429221328569
Pubmed

TFII-I gene family during tooth development: candidate genes for tooth anomalies in Williams syndrome.

GTF2IRD2 GTF2IRD2B

4.02e-06429217823943
Pubmed

Evolution of general transcription factors.

GTF2IRD2 GTF2IRD2B

4.02e-06429223229069
Pubmed

GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members.

GTF2IRD2 GTF2IRD2B

4.02e-06429222899722
Pubmed

Identification and characterization of TMEM16E and TMEM16F genes in silico.

ANO5 ANO6

1.00e-05629215067359
Pubmed

ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins.

ANO5 ANO6

1.41e-05729222075693
Pubmed

Anoctamins are a family of Ca2+-activated Cl- channels.

ANO5 ANO6

1.87e-05829222946059
Pubmed

Expression and function of epithelial anoctamins.

ANO5 ANO6

1.87e-05829220056604
Pubmed

Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels.

ANO5 ANO6

3.01e-051029219015192
Pubmed

Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members.

ANO5 ANO6

3.01e-051029223532839
Pubmed

N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis.

ATE1 DNAJC10

3.01e-051029229507222
Pubmed

Structure and function of TMEM16 proteins (anoctamins).

ANO5 ANO6

3.01e-051029224692353
Pubmed

Transcriptional fates of human-specific segmental duplications in brain.

GTF2IRD2 GTF2IRD2B

1.14e-041929230228200
Pubmed

TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis.

TRAF4 DNAJC10

2.88e-043029223973329
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

MICAL3 AP4B1 ATE1 DBT SEC24B

6.39e-0485329528718761
GeneFamilyAnoctamins

ANO5 ANO6

4.68e-0510192865
ToppCellmild-B_intermediate|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ZDHHC21 MICAL3 TRAF4 DNAJC10

8.25e-06200294fe815824e9e4be3f3db73610e3814a7fd533da65
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Mucinous_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

ANO5 RXFP1 MUC2

7.97e-05129293b0c3cbab552e1d540e6b03a691dd245f81715e0b
ToppCelldroplet-Heart-nan-18m-Hematologic-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCR2 RXFP1 ZNF473

1.56e-041622937f425a3983325a5a3ea33f812b15aa010cc55de0
ToppCell356C-Myeloid-Macrophage-SPP1+_Macrophage_4|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

C1QB ZNF473 FRMD6

1.68e-041662938d5d09f25e8903d481c2097fed435e69d42ccdb5
ToppCellfacs-Lung-24m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l14|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CCR2 C1QB PGM2L1

1.77e-04169293813472d429c0b12580b17b440e00a6d8beb7947f
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_memory-B_memory-6|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZDHHC21 MICAL3 TRAF4

1.96e-04175293eaec7fda07a9537d067ca13b607a8ab201caa7c4
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-early_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RXFP1 FRMD6 PREP

2.00e-0417629329cda51a99100ddd2928cadc92da40f001d7e1f4
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-early_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RXFP1 FRMD6 PREP

2.00e-0417629301774a86d7d92f31a056b753f9844f923038003e
ToppCelldroplet-Lung-30m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CCR2 DNAJC10 ZNF473

2.10e-04179293af03705a783e77f75c44fdfa793cfdccbf9dd91c
ToppCellnormal-na-Lymphocytic_B-B_mem-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

ZDHHC21 MICAL3 DNAJC10

2.20e-04182293ee36ea6cb9a5a08aeb83f2b7a249255f0b1a9870
ToppCelldroplet-Marrow-nan-3m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZDHHC21 CCR2 DNAJC10

2.20e-04182293bc8d621be57f76d718d9b0f11e023b0f4dcb668d
ToppCellMild/Remission-B_intermediate-0|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ZDHHC21 TRAF4 MOB3A

2.42e-04188293614032d18f8060bb12d1af7a1cf1cf4d8b2b505b
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PGM2L1 MICAL3 RXFP1

2.46e-041892938c8ca3b30d9be6c854615459a7bfba82b427c8bc
ToppCellCTRL-Lymphoid-B_cell|Lymphoid / Disease state, Lineage and Cell class

ZDHHC21 MICAL3 MOB3A

2.46e-0418929314f3a8c0f4f057ad4e6839b4c3eeaf956d6dc92e
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PGM2L1 MICAL3 RXFP1

2.46e-041892935d902a4660a27548764bf04c6de152b565da835c
ToppCellCF-Lymphoid-B_cell|CF / Disease state, Lineage and Cell class

ZDHHC21 MICAL3 ZC3H8

2.50e-04190293374d8fd63c733178acab07682ed1519693efab45
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZDHHC21 MICAL3 TRAF4

2.50e-041902930db545a4cba7534bad2693e0d565cde7dbc7a586
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-0|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZDHHC21 MICAL3 TRAF4

2.54e-041912935a9a592875fbd0b1429b48db29a760fdc9c2c856
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-0|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZDHHC21 MICAL3 TRAF4

2.54e-04191293b7d17d3ba488378b30f3732f8109f4a7c1673e61
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_B-B_mem-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ZDHHC21 MICAL3 DNAJC10

2.58e-0419229380a71ab3434076803466ccac0df73468889c7dd3
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_B-B_mem|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ZDHHC21 MICAL3 DNAJC10

2.58e-0419229375ce635d669ff77d1fd54e10467f21d5e5d67b08
ToppCellmoderate-Lymphoid-B_cell|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ZDHHC21 MICAL3 TRAF4

2.58e-04192293ae3727503c3b9f4695e565fd3161cc33b898f349
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZDHHC21 MICAL3 TRAF4

2.62e-04193293bbea475d2c4c7b29674ff302529f8f83dd666dcb
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_intermediate|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZDHHC21 MICAL3 TRAF4

2.62e-041932937cc10e8b51091869d46e462f3214999e7b5348b1
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZDHHC21 MICAL3 TRAF4

2.62e-04193293749faa5c592ee354733f5a7363a4277ef3462b93
ToppCellCF-Lymphoid|CF / Disease state, Lineage and Cell class

ZDHHC21 MICAL3 ZC3H8

2.62e-0419329311de07d13a7da223990b56fa89ba7fc1c3dd0122
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ZDHHC21 MICAL3 TRAF4

2.62e-04193293b5e44fe60dc84dc050d4fa3ccec4e257e51dc636
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_intermediate|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ZDHHC21 MICAL3 TRAF4

2.62e-04193293e2cf2f4f142e1b4dda3ded28b5208eef3f301a43
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_intermediate|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

ZDHHC21 MICAL3 TRAF4

2.66e-041942932b61023a602d336ed0de174e9141046173db34e6
ToppCellCOVID-19_Mild-Lymphoid_B-B_intermediate|COVID-19_Mild / Disease group, lineage and cell class

ZDHHC21 MICAL3 TRAF4

2.66e-04194293bf6f72a489c62cbf1a679552d8c5eaaaa0b99d33
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_intermediate-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ZDHHC21 MICAL3 TRAF4

2.66e-04194293f2486b19ac52a48d19f80b38a5536bee3dad745b
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-B_mem-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ZDHHC21 MICAL3 DNAJC10

2.70e-0419529351e6cfecd66a874673d0b79a295489a358bddfd5
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-B_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ZDHHC21 MICAL3 DNAJC10

2.70e-0419529330eccfc08106627fae49b93094bbb40fd6888db2
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MICAL3 DNAJC10 MOB3A

2.70e-04195293481989d2e5bd2582da3d86b0155c4d6615317067
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MICAL3 DNAJC10 MOB3A

2.70e-041952936108a27523d1b93a7fbe35cb95704a5ad9071e3c
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-B_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ZDHHC21 MICAL3 DNAJC10

2.70e-04195293e0b16ba18092e235d37c67f0762c80a5ec1714f8
ToppCellmild_COVID-19-B_intermediate|mild_COVID-19 / disease group, cell group and cell class (v2)

ZDHHC21 MICAL3 TRAF4

2.78e-04197293f669500120646f69355a6f920b892a6f2faeab63
ToppCellmild_COVID-19-B_intermediate|World / disease group, cell group and cell class (v2)

ZDHHC21 MICAL3 TRAF4

2.78e-04197293e909b898b7458071f176b6c04356ea3540589153
ToppCell(5)_Dendritic_cell-(54)_pDC|(5)_Dendritic_cell / shred on Cell_type and subtype

ZDHHC21 TRAF4 ZC3H8

2.82e-04198293fc6c6b60dddd7f2f997af0f87fae33f1c23f34a8
ToppCellKidney-Leukocytes|Kidney / Skin and Kidney Cells in Lupus Nephritis Patients.

CCR2 C1QB MOB3A

2.82e-041982934050553f292ce00d547bc79207d6b9a44f4db34f
ToppCellcontrol-B_intermediate|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ZDHHC21 MICAL3 TRAF4

2.82e-04198293e24345c8cec8c21f7b5163b7326ba8f83a587ce3
ToppCellmild-B_memory|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ZDHHC21 MICAL3 TRAF4

2.86e-04199293e6ac9a0959b0de2c6a99298feb7715aa80ade1dd
ToppCellsevere-B_memory|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ZDHHC21 MICAL3 TRAF4

2.86e-041992936d3436dd65d525aaa23ec02672005380f21c4d0f
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-B-B_intermediate|COVID-19_Mild / Disease, condition lineage and cell class

ZDHHC21 MICAL3 TRAF4

2.86e-041992931c6a08d01f6c1a2a4b6587d3a4522efbd03275e1
ToppCellmild-B_memory|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ZDHHC21 MICAL3 TRAF4

2.86e-04199293025bb65629d9e20c374e8f1ba08c36d1bb569190
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-B-B_intermediate|COVID-19_Severe / Disease, condition lineage and cell class

ZDHHC21 MICAL3 TRAF4

2.86e-04199293ad3c369a67926725917b771094f82ca6dd2af783
ToppCellmild-B_intermediate|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ZDHHC21 MICAL3 TRAF4

2.90e-042002938e3132a1fe3708f725c5c4077878fb87bbea3678
Diseaseresponse to angiotensin-converting enzyme inhibitor

ATE1 PREP

2.49e-0378282EFO_0005325
Diseasesusceptibility to scarlet fever measurement

ATE1 SEC24B

2.56e-0379282EFO_0008409

Protein segments in the cluster

PeptideGeneStartEntry
SCFYVAFFKGKFVGY

ANO5

571

Q75V66
FSSHYKKFFCSYSEP

AP4B1

311

Q9Y6B7
CFYIAFFKGKFVGYP

ANO6

566

Q4KMQ2
YVCFFGYPSFKYSHP

DBT

36

P11182
KFYCKPHYCYRLSGY

MICAL3

811

Q7RTP6
CYKHFYYFVKEFGLI

MOB3A

186

Q96BX8
TFDGKTYTFHGDCYY

MUC2

401

Q02817
KYGYHISKTSYFLCY

PGM2L1

481

Q6PCE3
KAFDRFFIHYPYCYG

PRPF39

116

Q86UA1
YSCHFKKGKRYFYFY

PREP

76

P48147
KHYGKYFEPEAYFPS

FRMD6

171

Q96NE9
VFPFHYKNGTYYDCI

BSPH1

46

Q075Z2
TCKVPGLYYFTYHAS

C1QB

161

P02746
TTFFDYDYGAPCHKF

CCR2

21

P41597
LSYYYMGFYIHSCPK

ATE1

401

O95260
FFPPKSNKAYHYHSY

DNAJC10

636

Q8IXB1
YKYLWGSYPKYKHHC

GTF2IRD2

891

Q86UP8
YKYLWGSYPKYKHHC

GTF2IRD2B

891

Q6EKJ0
SKYSAGCIYYYPSFH

SEC24B

881

O95487
EAFKHLYFEKFPGYY

ACSS3

521

Q9H6R3
YTCNFLGCKKFYYSK

RLF

801

Q13129
HIYFKKFQYCGYAPH

RXFP1

371

Q9HBX9
ECFSPAFYTHKYGYK

TRAF4

331

Q9BUZ4
MFSFCHYYYFLPLKK

ZDHHC21

151

Q8IVQ6
YGCYAAKKYSYGHLP

ZZEF1

1856

O43149
YHFKKGTEICNYSYS

WIPI1

86

Q5MNZ9
PYKCREYYKGFDHNS

ZNF214

581

Q9UL59
PKTHTGYKFYVCNEY

ZNF473

256

Q8WTR7
EYPCKFYHTGTKCYQ

ZC3H8

246

Q8N5P1