Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein serine kinase activity

TNIK TLK1 MAP4K4 CDK13 DSTYK MINK1

4.25e-05363366GO:0106310
GeneOntologyMolecularFunctionprotein kinase activity

TNIK MST1 TLK1 MAP4K4 CDK13 DSTYK MINK1

8.35e-05600367GO:0004672
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

TNIK TLK1 MAP4K4 CDK13 DSTYK MINK1

1.32e-04446366GO:0004674
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

TNIK MST1 TLK1 MAP4K4 CDK13 DSTYK MINK1

2.35e-04709367GO:0016773
GeneOntologyMolecularFunctionkinase activity

TNIK MST1 TLK1 MAP4K4 CDK13 DSTYK MINK1

3.69e-04764367GO:0016301
GeneOntologyMolecularFunctionhistone H3K4 methyltransferase activity

SETD7 ASH2L

5.88e-0420362GO:0042800
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

TNIK MST1 TLK1 MAP4K4 CDK13 DSTYK MINK1

1.25e-03938367GO:0016772
GeneOntologyMolecularFunctioncyclin binding

CDK13 RBM4

1.81e-0335362GO:0030332
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

SETD7 ASH2L

2.85e-0344362GO:0140938
GeneOntologyBiologicalProcessmicrovillus assembly

TNIK MAP4K4 MINK1

1.55e-0528363GO:0030033
GeneOntologyBiologicalProcessmicrovillus organization

TNIK MAP4K4 MINK1

2.82e-0534363GO:0032528
DomainCNH

TNIK MAP4K4 MINK1

2.36e-0614363SM00036
DomainCNH

TNIK MAP4K4 MINK1

2.95e-0615363PS50219
DomainCNH_dom

TNIK MAP4K4 MINK1

2.95e-0615363IPR001180
DomainCNH

TNIK MAP4K4 MINK1

2.95e-0615363PF00780
DomainSer/Thr_kinase_AS

TNIK TLK1 MAP4K4 CDK13 DSTYK MINK1

5.61e-05357366IPR008271
DomainS_TKc

TNIK TLK1 MAP4K4 CDK13 DSTYK MINK1

5.79e-05359366SM00220
DomainPROTEIN_KINASE_ST

TNIK TLK1 MAP4K4 CDK13 DSTYK MINK1

6.06e-05362366PS00108
DomainProtein_kinase_ATP_BS

TNIK TLK1 MAP4K4 CDK13 DSTYK MINK1

7.81e-05379366IPR017441
DomainPkinase

TNIK TLK1 MAP4K4 CDK13 DSTYK MINK1

8.04e-05381366PF00069
DomainMIR

POMT2 ITPR2

1.61e-0410362PS50919
DomainMIR

POMT2 ITPR2

1.61e-0410362PF02815
DomainMIR

POMT2 ITPR2

1.61e-0410362SM00472
DomainMIR_motif

POMT2 ITPR2

1.61e-0410362IPR016093
DomainPROTEIN_KINASE_ATP

TNIK TLK1 MAP4K4 CDK13 DSTYK MINK1

2.22e-04459366PS00107
DomainProt_kinase_dom

TNIK TLK1 MAP4K4 CDK13 DSTYK MINK1

3.12e-04489366IPR000719
DomainEamA_dom

SLC35G6 SLC35G4

3.24e-0414362IPR000620
DomainEamA

SLC35G6 SLC35G4

3.24e-0414362PF00892
DomainPROTEIN_KINASE_DOM

TNIK TLK1 MAP4K4 CDK13 DSTYK MINK1

3.26e-04493366PS50011
DomainKelch_1

KLHL32 ATRNL1 KLHL4

3.29e-0470363PF01344
DomainKelch_1

KLHL32 ATRNL1 KLHL4

3.29e-0470363IPR006652
DomainMORN

SETD7 RSPH1

3.73e-0415362PF02493
DomainMORN

SETD7 RSPH1

3.73e-0415362IPR003409
DomainKringle

MST1 LPA

4.82e-0417362IPR000001
DomainKringle

MST1 LPA

4.82e-0417362PF00051
DomainKRINGLE_1

MST1 LPA

4.82e-0417362PS00021
DomainKringle_CS

MST1 LPA

4.82e-0417362IPR018056
DomainKR

MST1 LPA

4.82e-0417362SM00130
DomainKRINGLE_2

MST1 LPA

4.82e-0417362PS50070
DomainKinase-like_dom

TNIK TLK1 MAP4K4 CDK13 DSTYK MINK1

5.39e-04542366IPR011009
DomainLIPASE_SER

LIPA LIPG

1.14e-0326362PS00120
DomainKringle-like

MST1 LPA

1.73e-0332362IPR013806
Domain-

KLHL32 ATRNL1

3.85e-03483622.120.10.80
DomainKelch-typ_b-propeller

KLHL32 ATRNL1

5.03e-0355362IPR015915
DomainKelch

KLHL32 KLHL4

5.58e-0358362SM00612
DomainBACK

KLHL32 KLHL4

5.96e-0360362SM00875
DomainBACK

KLHL32 KLHL4

6.15e-0361362PF07707
DomainBACK

KLHL32 KLHL4

6.15e-0361362IPR011705
DomainRRM_1

PABPN1L RBMXL3 RBM4

7.42e-03208363PF00076
DomainRRM

PABPN1L RBMXL3 RBM4

8.33e-03217363SM00360
DomainRRM_dom

PABPN1L RBMXL3 RBM4

9.42e-03227363IPR000504
DomainRRM

PABPN1L RBMXL3 RBM4

9.76e-03230363PS50102
Domain-

PABPN1L RBMXL3 RBM4

1.14e-022443633.30.70.330
DomainNucleotide-bd_a/b_plait

PABPN1L RBMXL3 RBM4

1.33e-02258363IPR012677
PathwayWP_HIPPOYAP_SIGNALING

TNIK MST1 MAP4K4 MINK1

5.51e-0822254M39821
PathwayREACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE

TNIK MAP4K4 MINK1

3.68e-0537253MM14899
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

GRM1 ITPR2

1.35e-0410252M47661
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

GRM1 ITPR2

1.64e-0411252M49033
PathwayKEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY

GRM1 ITPR2

2.33e-0413252M47656
PathwayWP_CHOLESTEROL_METABOLISM

LIPA LIPG LPA

2.71e-0472253M46457
PathwayREACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE

LIPA LIPG LPA

3.06e-0475253M27032
Pubmed

Rap2A links intestinal cell polarity to brush border formation.

TNIK MAP4K4 MINK1

4.59e-071536322797597
Pubmed

PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.

FARSA UPF1 ASH2L USP9X RBM4

2.91e-0621736531685992
Pubmed

RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell.

MAP4K4 RBM4

3.12e-06336229138007
Pubmed

MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1.

TNIK MINK1

3.12e-06336218930710
Pubmed

SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis.

USP9X SNX17

3.12e-06336231671755
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

DCHS1 TNIK FARSA UPF1 GRM1 MAP4K4 USP9X MINK1

5.10e-0696336828671696
Pubmed

RT-PCR of fatty acid elongases.

SLC35G6 SLC35G4

6.24e-0643629056918
Pubmed

Emergence of primate genes by retrotransposon-mediated sequence transduction.

SLC35G6 SLC35G4

6.24e-06436217101974
Pubmed

RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis.

MAP4K4 RBM4

6.24e-06436230200638
Pubmed

The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1.

MAP4K4 MINK1

6.83e-051236235027733
Pubmed

Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.

SETD7 ASH2L

8.07e-051336224619213
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

TNIK UPF1 MAP4K4 ASH2L USP9X RBM4 SNX17

8.09e-05103836726673895
Pubmed

Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells.

FARSA USP9X TM9SF1

9.83e-058636325044020
Pubmed

Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.

LPA SNX17

1.58e-041836223726366
Pubmed

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.

TLK1 ASH2L

1.76e-041936222267201
Pubmed

Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.

SETD7 ASH2L

1.96e-042036219047629
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

TNIK GRM1 USP9X MINK1

2.00e-0428136428706196
Pubmed

Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.

SETD7 ASH2L

2.16e-042136212670868
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

TNIK MAP4K4 ASH2L USP9X

3.02e-0431336438270169
Pubmed

LZTR1 is a regulator of RAS ubiquitination and signaling.

TNIK MAP4K4 MINK1

3.11e-0412736330442766
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

MST1 TLK1 UPF1 MAP4K4 CDK13 ASH2L USP9X

3.66e-04132736732694731
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

MAP4K4 CDK13 ASH2L DSTYK MINK1

5.24e-0465036538777146
Pubmed

Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of mastication.

SETD7 ASH2L

5.39e-043336224705356
Pubmed

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.

FARSA UPF1 MAP4K4 CDK13 USP9X

5.81e-0466536530457570
Pubmed

Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.

MAP4K4 CDK13 USP9X MINK1

7.52e-0439936437536630
Pubmed

Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.

ITGAL ITPR2

7.54e-043936224556642
Pubmed

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.

FLG2 MAP4K4 CDK13 MINK1

7.66e-0440136425852190
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

FARSA UPF1 MAP4K4 USP9X MINK1

7.71e-0470836539231216
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

FARSA LIPA UPF1 FLG2 MAP4K4 RBM4

7.83e-04108236638697112
Pubmed

Update on the Kelch-like (KLHL) gene family.

KLHL32 KLHL4

8.33e-044136223676014
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

TNIK FARSA MAP4K4 RBM4 ITPR2

9.00e-0473336534672954
Pubmed

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.

TNIK UPF1 USP9X ITPR2

9.93e-0443036432581705
InteractionCEP170 interactions

TNIK SETD7 UPF1 USP9X DSTYK SNX17

1.63e-05318356int:CEP170
InteractionSTRIP1 interactions

TNIK MAP4K4 RBM4 MINK1

2.35e-0597354int:STRIP1
CytobandEnsembl 112 genes in cytogenetic band chr8p11

NKX6-3 ASH2L

2.99e-03103362chr8p11
GeneFamilyLipases|Arylacetamide deacetylase family

LIPA LIPG

6.02e-0422302464
GeneFamilyKelch like|BTB domain containing

KLHL32 KLHL4

2.20e-0342302617
GeneFamilyRNA binding motif containing

PABPN1L RBMXL3 RBM4

5.18e-03213303725
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_1|390C / Donor, Lineage, Cell class and subclass (all cells)

POMT2 MST1 CDK13 DSTYK MINK1

3.89e-07186365064b6047215597465bb51a8a1547ef5a226552f9
ToppCelldroplet-Marrow-nan-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIPA ITGAL DSTYK MINK1

1.01e-05168364e979a4fbeb9f21048b47d69e6da75c57650697f2
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like-C|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FARSA RBM4 TM9SF1 KLHL4

1.44e-05184364629cfed10e1112cf30f6a828ce9efbbc6b207789
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

POMT2 MST1 DSTYK MINK1

1.57e-05188364b1ec7c45aedcc3d22cac898c6a3679e7f8b44c77
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

POMT2 MST1 DSTYK MINK1

1.57e-051883642c4e791df69a9df29922f9117e5cac7787c129ce
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like-B|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FARSA RBM4 TM9SF1 KLHL4

1.63e-05190364c41b71ecd49cc5a82be9dde79093490fd2196432
ToppCellBronchial-NucSeq-Stromal-Mesofibroblastic-Mesothelia|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MST1 ATRNL1 ATCAY KLHL4

1.84e-05196364ce13af36fc2932e8125013041742593ff3d07e86
ToppCellBronchial-NucSeq-Stromal-Mesofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MST1 ATRNL1 ATCAY KLHL4

1.84e-0519636496e5c6d155273e82ebafa180df8bb589c3e3e54e
Diseaseremnant cholesterol measurement

LIPG LPA SNX17

2.63e-04108343EFO_0010815
Diseasesphingomyelin measurement

UPF1 LIPG LPA MINK1

2.86e-04278344EFO_0010118
Diseaseomega-3 polyunsaturated fatty acid measurement

LIPG LPA SNX17

3.41e-04118343EFO_0010119
DiseaseC-reactive protein measurement

TLK1 LIPA MAP4K4 LIPG DSTYK LPA SNX17

3.82e-041206347EFO_0004458
Diseasefree cholesterol to total lipids in large VLDL percentage

LIPG LPA

8.37e-0437342EFO_0022281
Diseasecholesteryl esters to total lipids in medium LDL percentage

LIPG LPA

8.37e-0437342EFO_0022252
Diseaseepilepsy (implicated_via_orthology)

TNIK MAP4K4 MINK1

8.73e-04163343DOID:1826 (implicated_via_orthology)
Diseasedegree of unsaturation measurement

LIPG LPA

9.30e-0439342EFO_0022261
DiseaseHypercholesterolemia

LIPA LPA

9.30e-0439342C0020443
Diseasecholesteryl esters to total lipids in small LDL percentage

LIPG LPA

1.08e-0342342EFO_0022255
Diseasecholesteryl esters to total lipids in small HDL percentage

LIPG LPA

1.13e-0343342EFO_0022254

Protein segments in the cluster

PeptideGeneStartEntry
HRSVYVGNVDYGGSA

PABPN1L

146

A6NDY0
SGYRSAENAYGGHRG

BPIFB4

121

P59827
QGPGYSQGYRGHIST

CDK13

1486

Q14004
SIGKHYSSGYGQGDV

ASH2L

471

Q9UBL3
VGEGYGYGHESELSQ

RBM4

321

Q9BWF3
GDYSIGVNGHLSGAY

ITPR2

1706

Q14571
ANGHVTYYLGAGTAG

DCHS1

1886

Q96JQ0
YGQYGSRETSGFGQH

FLG2

556

Q5D862
VGNGTYGQVYKGRHV

MAP4K4

31

O95819
KVVTHGGYYGEGLNA

ATCAY

176

Q86WG3
IGYSLGAHVAGYAGN

LIPG

166

Q9Y5X9
VDLHGSVIDYNYGGG

DSTYK

711

Q6XUX3
GVATYNGFLYVVGGH

KLHL4

611

Q9C0H6
TYQGERAYQHGGVTG

UPF1

1111

Q92900
GVQECYHGNGQSYRG

LPA

366

P08519
GVQECYHGNGQSYQG

LPA

936

P08519
GAIVQGGYGHTSVYD

ATRNL1

461

Q5VV63
YHGAGEQYRGTVSKT

MST1

371

P26927
YVSAVHTEGNYGESG

GRM1

226

Q13255
VGNGTYGQVYKGRHV

MINK1

31

Q8N4C8
SGGHYYSYIIQRNGG

USP9X

1876

Q93008
HYQVTGYGINGTGDS

POMT2

436

Q9UKY4
VKRTHSQGGYGSQGY

FARSA

296

Q9Y285
HVAGFGGLSSQGVYY

NKX6-3

76

A6NJ46
QGVYTYEDGGVLQGT

SETD7

71

Q8WTS6
QRHGQGTYLYAETGS

RSPH1

121

Q8WYR4
AGRHFGYRVLQVGNG

ITGAL

41

P20701
QEGTTGVYTGLGYVQ

SLC35G4

181

P0C7Q5
GGSAYVAYNIHVNGV

SNX17

16

Q15036
GRGHKISDYFEYQGG

TLK1

141

Q9UKI8
VGNGTYGQVYKGRHV

TNIK

31

Q9UKE5
SDRYGVGGHYEENRG

RBMXL3

501

Q8N7X1
QEGITGVYTALGYGQ

SLC35G6

181

P0C7Q6
HVNVEYGKGIGYSSG

ZNF233

286

A6NK53
SGYVSSHFYRQIGGE

TM9SF1

356

O15321
GVAVHNGRIYLVGGY

KLHL32

541

Q96NJ5
EQVYYVGHSQGTTIG

LIPA

166

P38571