Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	neonatal lethality, incomplete penetrance	HLTF DACT1 DAAM1 SUCO ALX4 UBE2W	3.44e-05	298	30	6	MP:0011088
Domain	SUN	SUCO SUN2	7.36e-05	6	42	2	PS51469
Domain	SUN_dom	SUCO SUN2	1.03e-04	7	42	2	IPR012919
Domain	Sad1_UNC	SUCO SUN2	1.03e-04	7	42	2	PF07738
Domain	RhoGAP	ARHGAP32 ABR ARHGAP20	3.65e-04	62	42	3	SM00324
Domain	RhoGAP	ARHGAP32 ABR ARHGAP20	3.82e-04	63	42	3	PF00620
Domain	RHOGAP	ARHGAP32 ABR ARHGAP20	4.00e-04	64	42	3	PS50238
Domain	RhoGAP_dom	ARHGAP32 ABR ARHGAP20	4.00e-04	64	42	3	IPR000198
Domain	-	ARHGAP32 ABR ARHGAP20	4.00e-04	64	42	3	1.10.555.10
Domain	Rho_GTPase_activation_prot	ARHGAP32 ABR ARHGAP20	1.02e-03	88	42	3	IPR008936
Domain	RA	RAPGEF2 ARHGAP20	2.96e-03	36	42	2	PF00788
Domain	RA	RAPGEF2 ARHGAP20	3.13e-03	37	42	2	PS50200
Domain	RA_dom	RAPGEF2 ARHGAP20	3.65e-03	40	42	2	IPR000159
Pathway	REACTOME_CDC42_GTPASE_CYCLE	ARHGAP32 GIT2 DAAM1 ABR ARHGAP20	2.03e-05	155	31	5	M41808
Pathway	REACTOME_RHOA_GTPASE_CYCLE	ARHGAP32 DAAM1 ABR ARHGAP20	2.51e-04	142	31	4	MM15576
Pathway	REACTOME_RHOA_GTPASE_CYCLE	ARHGAP32 DAAM1 ABR ARHGAP20	3.02e-04	149	31	4	M41805
Pathway	REACTOME_RHOB_GTPASE_CYCLE	ARHGAP32 DAAM1 ABR	4.57e-04	69	31	3	MM15596
Pathway	REACTOME_RHOB_GTPASE_CYCLE	ARHGAP32 DAAM1 ABR	4.77e-04	70	31	3	M41806
Pathway	REACTOME_RHOC_GTPASE_CYCLE	ARHGAP32 DAAM1 ABR	4.77e-04	70	31	3	MM15597
Pathway	REACTOME_RAC1_GTPASE_CYCLE	ARHGAP32 GIT2 ABR ARHGAP20	5.56e-04	175	31	4	MM15599
Pathway	REACTOME_RHOC_GTPASE_CYCLE	ARHGAP32 DAAM1 ABR	5.62e-04	74	31	3	M41807
Pathway	REACTOME_RAC1_GTPASE_CYCLE	ARHGAP32 GIT2 ABR ARHGAP20	6.71e-04	184	31	4	M41809
Pathway	REACTOME_RAC2_GTPASE_CYCLE	ARHGAP32 GIT2 ABR	9.01e-04	87	31	3	MM15600
Pathway	REACTOME_RAC2_GTPASE_CYCLE	ARHGAP32 GIT2 ABR	9.31e-04	88	31	3	M41810
Pathway	REACTOME_RAC3_GTPASE_CYCLE	ARHGAP32 GIT2 ABR	1.09e-03	93	31	3	MM15609
Pathway	REACTOME_RAC3_GTPASE_CYCLE	ARHGAP32 GIT2 ABR	1.13e-03	94	31	3	M41818
Pathway	REACTOME_CDC42_GTPASE_CYCLE	ARHGAP32 ABR ARHGAP20	1.13e-03	94	31	3	MM15598
Pathway	REACTOME_RHO_GTPASE_CYCLE	ARHGAP32 GIT2 DAAM1 ABR ARHGAP20	2.49e-03	439	31	5	MM15595
Pathway	REACTOME_RHO_GTPASE_CYCLE	ARHGAP32 GIT2 DAAM1 ABR ARHGAP20	2.77e-03	450	31	5	M27078
Pubmed	Patterning of the lateral ganglionic eminence by the Gsh1 and Gsh2 homeobox genes regulates striatal and olfactory bulb histogenesis and the growth of axons through the basal ganglia.	DRD2 TBR1 NPY	4.18e-06	26	42	3	12724834
Pubmed	Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity.	PCNX1 ZMYND11 TBR1	7.19e-06	31	42	3	27321927
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	DRD2 RYR3	8.53e-06	4	42	2	18206662
Pubmed	DNA Damage Regulates Translation through β-TRCP Targeting of CReP.	DACT1 RAPGEF2 SUN2	1.04e-05	35	42	3	26091241
Pubmed	Aberrant RNA methylation triggers recruitment of an alkylation repair complex.	RIF1 SRRM2	2.13e-05	6	42	2	34686315
Pubmed	Potential genetic variants in schizophrenia: a Bayesian analysis.	DRD2 NPY	2.13e-05	6	42	2	17366345
Pubmed	Hypothalamic orexin, OX1, alphaMSH, NPY and MCRs expression in dopaminergic D2R knockout mice.	DRD2 NPY	2.98e-05	7	42	2	19570576
Pubmed	Spatial transcriptome reveals the region-specific genes and pathways regulated by Satb2 in neocortical development.	TBR1 NPY	6.37e-05	10	42	2	39095712
Pubmed	Selective dopamine D2 receptor deletion from Nkx6.2 expressing cells causes impaired cognitive, motivation and anxiety phenotypes in mice.	DRD2 NPY	7.78e-05	11	42	2	37945756
Pubmed	Ablation of Vti1a/1b Triggers Neural Progenitor Pool Depletion and Cortical Layer 5 Malformation in Late-embryonic Mouse Cortex.	TBR1 VTI1B	7.78e-05	11	42	2	33774122
Pubmed	Excess LINC complexes impair brain morphogenesis in a mouse model of recessive TOR1A disease.	TBR1 SUN2	9.32e-05	12	42	2	29868845
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	ARHGAP32 RIF1 ZNF22 GIT2 ABR PPIP5K2 ARHGAP20	1.04e-04	916	42	7	32203420
Pubmed	Sonic hedgehog signaling confers ventral telencephalic progenitors with distinct cortical interneuron fates.	TBR1 NPY	1.10e-04	13	42	2	20159447
Pubmed	Sdmg1 is a conserved transmembrane protein associated with germ cell sex determination and germline-soma interactions in mice.	TMEM184A VTI1B	1.10e-04	13	42	2	18321981
Pubmed	SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.	TBR1 SUN2	1.28e-04	14	42	2	19874786
Pubmed	β-Catenin Deletion in Regional Neural Progenitors Leads to Congenital Hydrocephalus in Mice.	TBR1 NPY	1.28e-04	14	42	2	34460072
Pubmed	Three human ARX mutations cause the lissencephaly-like and mental retardation with epilepsy-like pleiotropic phenotypes in mice.	TBR1 NPY	1.48e-04	15	42	2	19605412
Pubmed	Embryonic and postnatal development of mouse olfactory tubercle.	TBR1 NPY	1.69e-04	16	42	2	31200100
Pubmed	SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis.	TBR1 SMC6	1.69e-04	16	42	2	33200984
Pubmed	Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1.	TBR1 NPY	1.91e-04	17	42	2	19549840
Pubmed	DLX5 regulates development of peripheral and central components of the olfactory system.	TBR1 NPY	1.91e-04	17	42	2	12533617
Pubmed	A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area.	TBR1 NPY	1.91e-04	17	42	2	22090484
Pubmed	Sonic hedgehog expressing and responding cells generate neuronal diversity in the medial amygdala.	TBR1 NPY	1.91e-04	17	42	2	20507551
Pubmed	The p75 neurotrophin receptor is required for the survival of neuronal progenitors and normal formation of the basal forebrain, striatum, thalamus and neocortex.	TBR1 NPY	2.15e-04	18	42	2	31488566
Pubmed	A subpopulation of dorsal lateral/caudal ganglionic eminence-derived neocortical interneurons expresses the transcription factor Sp8.	TBR1 NPY	2.15e-04	18	42	2	22021915
Pubmed	The cell-intrinsic requirement of Sox6 for cortical interneuron development.	TBR1 NPY	2.15e-04	18	42	2	19709629
Pubmed	miRNAs are Essential for the Survival and Maturation of Cortical Interneurons.	TBR1 NPY	2.40e-04	19	42	2	24451661
Pubmed	BS69/ZMYND11 reads and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing.	ZMYND11 SRRM2	2.40e-04	19	42	2	25263594
Pubmed	Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption.	DRD2 NPY	2.40e-04	19	42	2	20554694
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	DAAM1 ZBED4 SUN2	2.59e-04	102	42	3	9734811
Pubmed	Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation.	DRD2 NPY	2.67e-04	20	42	2	17460091
Pubmed	Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon.	TBR1 NPY	2.67e-04	20	42	2	16221724
Pubmed	SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development.	TBR1 NPY	2.95e-04	21	42	2	19657336
Pubmed	Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon.	DRD2 TBR1	3.24e-04	22	42	2	11124115
Pubmed	Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53.	TBR1 NPY	3.24e-04	22	42	2	19020049
Pubmed	The DNA sequence and analysis of human chromosome 14.	DACT1 PCNX1 DAAM1	3.32e-04	111	42	3	12508121
Pubmed	Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C.	TBR1 NPY	3.54e-04	23	42	2	19859539
Pubmed	C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.	RIF1 SRRM2 SUN2	4.07e-04	119	42	3	35776542
Pubmed	The Zinc Finger Transcription Factor Sp9 Is Required for the Development of Striatopallidal Projection Neurons.	DRD2 NPY	4.20e-04	25	42	2	27452460
Pubmed	Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain.	TBR1 NPY	4.54e-04	26	42	2	24507192
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	HLTF RIF1 ZBED4	5.15e-04	129	42	3	23022380
Pubmed	Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons.	TBR1 NPY	5.28e-04	28	42	2	20392955
Pubmed	Satb2 regulates the development of dopaminergic neurons in the arcuate nucleus by Dlx1.	DRD2 NPY	5.28e-04	28	42	2	34564702
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	RIF1 ZNF22 ZMYND11 SRRM2 SUN2 VTI1B SMC6	5.44e-04	1203	42	7	29180619
Pubmed	NPAS1 represses the generation of specific subtypes of cortical interneurons.	TBR1 NPY	5.66e-04	29	42	2	25467980
Pubmed	Severe obesity is associated with novel single nucleotide polymorphisms of the ESR1 and PPARgamma locus in Han Chinese.	DRD2 NPY	6.90e-04	32	42	2	19491387
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	RIF1 SRRM2 SUN2 SMC6	7.58e-04	341	42	4	32971831
Pubmed	Transcription factors Bcl11a and Bcl11b are required for the production and differentiation of cortical projection neurons.	TBR1 NPY	7.79e-04	34	42	2	34963132
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	KCNIP4 MMS22L GIT2 RAB11FIP1 SRRM2 MYCBPAP SUN2	8.00e-04	1284	42	7	17353931
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	RIF1 ABR TMEM184A SUCO POLDIP3 TSFM	8.07e-04	925	42	6	28986522
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	RIF1 GIT2 TBR1 RAB11FIP1 PPIP5K2 VTI1B SMC6	9.45e-04	1321	42	7	27173435
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	ARHGAP32 NCKAP5 MMS22L UBE2W	9.55e-04	363	42	4	14691545
Pubmed	Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes.	RIF1 NCKAP5 ZBED4	1.05e-03	165	42	3	16107646
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	HLTF ZNF22 SRRM2 POLDIP3 SUN2	1.12e-03	655	42	5	35819319
Pubmed	Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes.	ZMYND11 SRRM2	1.19e-03	42	42	2	35705031
Cytoband	14q23.1	DACT1 DAAM1	8.60e-04	47	42	2	14q23.1
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ABR RAB11FIP1	1.31e-03	36	27	2	823
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP32 ARHGAP20	2.52e-03	50	27	2	721
Drug	0316684-0000 [391209-55-5]; Down 200; 10uM; PC3; HT_HG-U133A	PHKA2 GIT2 RAPGEF2 RAB11FIP1 SRRM2 TSFM	1.44e-06	194	42	6	7098_DN
Drug	Monocrotaline [315-22-0]; Down 200; 12.2uM; PC3; HT_HG-U133A	PCNX1 RIF1 ABR ZBED4 SRRM2 TSFM	1.53e-06	196	42	6	7127_DN
Drug	Homochlorcyclizine dihydrochloride [1982-36-1]; Down 200; 10.4uM; MCF7; HT_HG-U133A	PCNX1 ABR ZBED4 SLC35D2 SUN2 TSFM	1.62e-06	198	42	6	7417_DN
Drug	Remoxipride	DRD2 NPY	9.95e-06	3	42	2	ctd:D017330
Drug	Berberine chloride [633-65-8]; Down 200; 10.8uM; HL60; HG-U133A	HLTF GIT2 RAPGEF2 RAB11FIP1 PPIP5K2	2.67e-05	192	42	5	1778_DN
Drug	(-)-Quinpirole hydrochloride [85760-74-3]; Down 200; 15.6uM; MCF7; HT_HG-U133A	PHKA2 RIF1 DRD2 MAP3K12 POLDIP3	2.81e-05	194	42	5	3539_DN
Drug	Disopyramide [3737-09-5]; Up 200; 11.8uM; PC3; HT_HG-U133A	PHKA2 ZNF22 GIT2 RAPGEF2 SLC35D2	2.95e-05	196	42	5	7276_UP
Drug	rosiglitazone; Down 200; 10uM; MCF7; HT_HG-U133A	PHKA2 RIF1 GIT2 DAAM1 RAPGEF2	3.02e-05	197	42	5	1658_DN
Drug	Nifedipine [21829-25-4]; Down 200; 11.6uM; PC3; HT_HG-U133A	PHKA2 ARHGAP32 ZMYND11 GIT2 MAP3K12	3.10e-05	198	42	5	7303_DN
Drug	carmustine; Down 200; 100uM; MCF7; HT_HG-U133A	PHKA2 PCNX1 ZNF22 RAPGEF2 ZBED4	3.17e-05	199	42	5	6888_DN
Drug	Bisoprolol fumarate; Down 200; 9uM; MCF7; HT_HG-U133A	PHKA2 GIT2 RAPGEF2 SRRM2 SUN2	3.17e-05	199	42	5	2642_DN
Drug	Fipexide hydrochloride [34161-23-4]; Up 200; 9.4uM; PC3; HT_HG-U133A	PCNX1 ZMYND11 DRD2 TBR1 POLDIP3	3.25e-05	200	42	5	5737_UP
Disease	anxiety disorder (is_implicated_in)	DRD2 NPY	2.82e-05	6	41	2	DOID:2030 (is_implicated_in)
Disease	inferior temporal gyrus volume measurement	DRD2 DAAM1	1.03e-04	11	41	2	EFO_0010308
Disease	alcohol use disorder (implicated_via_orthology)	DRD2 SRRM2 NPY RYR3	1.55e-04	195	41	4	DOID:1574 (implicated_via_orthology)
Disease	depressive disorder (is_implicated_in)	DRD2 NPY	2.53e-04	17	41	2	DOID:1596 (is_implicated_in)
Disease	lingual gyrus volume measurement	KCNIP4 NCKAP5	3.17e-04	19	41	2	EFO_0010314
Disease	blood rubidium measurement	RIF1 NCKAP5	5.99e-04	26	41	2	EFO_0021529
Disease	Hyperkinesia, Generalized	DRD2 NPY	9.10e-04	32	41	2	C0751217
Disease	Hyperkinesia	DRD2 NPY	9.10e-04	32	41	2	C3887506
Disease	lactate measurement	PNMA5 ARHGAP20	1.35e-03	39	41	2	EFO_0007745
Disease	Memory Disorders	DRD2 NPY	1.64e-03	43	41	2	C0025261
Disease	Memory Loss	DRD2 NPY	1.64e-03	43	41	2	C0751295
Disease	Age-Related Memory Disorders	DRD2 NPY	1.64e-03	43	41	2	C0751292
Disease	Memory Disorder, Spatial	DRD2 NPY	1.64e-03	43	41	2	C0751294
Disease	Memory Disorder, Semantic	DRD2 NPY	1.64e-03	43	41	2	C0751293
Disease	Memory impairment	DRD2 NPY	1.72e-03	44	41	2	C0233794
Disease	Anxiety Disorders	DRD2 NPY	1.72e-03	44	41	2	C0003469
Disease	Anxiety neurosis (finding)	DRD2 NPY	1.72e-03	44	41	2	C1279420
Disease	Anxiety States, Neurotic	DRD2 NPY	1.72e-03	44	41	2	C0376280
Disease	hippocampal CA1 volume	DACT1 DAAM1	2.04e-03	48	41	2	EFO_0009394
Disease	depressive disorder (biomarker_via_orthology)	DRD2 NPY	2.39e-03	52	41	2	DOID:1596 (biomarker_via_orthology)
Disease	Withdrawal Symptoms	DRD2 NPY	2.96e-03	58	41	2	C0087169
Disease	Drug Withdrawal Symptoms	DRD2 NPY	2.96e-03	58	41	2	C0086189
Disease	Substance Withdrawal Syndrome	DRD2 NPY	2.96e-03	58	41	2	C0038587
Disease	Seizures	DRD2 NPY TSFM	3.45e-03	218	41	3	C0036572
Disease	common carotid intimal medial thickness	MMS22L RYR3	3.93e-03	67	41	2	EFO_0004860
Disease	Alcohol abuse	DRD2 NPY	3.93e-03	67	41	2	C0085762

Protein segments in the cluster

Peptide	Gene	Start	Entry
FTSRDMSLKRTPSKK	ABR	626	Q12979
PDRKTSSIAALRMKA	ALX4	386	Q9H161
PKSDMVRTSLRLLTS	GIT2	691	Q14161
ATIPKMLSSLLSERS	OR6K2	76	Q8NGY2
TLLEKSSDRRRSSMP	MMS22L	326	Q6ZRQ5
SASASSKELLMKLRR	TSFM	41	P43897
PLKAEKSMDSLRSLS	PCNX1	361	Q96RV3
RLMKLLPCSAAKTSS	KCNIP4	36	Q6PIL6
KLITFLRTFMKSRPT	ARHGAP32	341	A7KAX9
SLKTALRTKPMRFVT	DAAM1	136	Q9Y4D1
PLLDMKSSRIRSAKP	KLHL15	266	Q96M94
KILRFRSGSLKLMTT	DACT1	821	Q9NYF0
LLLRKMSSSSPDLLS	MAP3K12	601	Q12852
TRTSLKTMSRRKLSQ	DRD2	351	P14416
EKSKFRMSELSSSRP	HLTF	371	Q14527
ASMLSKSTVERLLLP	PPP4R1L	151	Q9P1A2
MTLPTKVLSAHRKSL	PHKA2	716	P46019
ILLRLSDSPSMKKES	POLDIP3	361	Q9BY77
KMKTLAERRRSAPSL	ARHGAP20	36	Q9P2F6
SKKPESRRSSLLSLM	RAB11FIP1	426	Q6WKZ4
SRRSSLLSLMTGKKD	RAB11FIP1	431	Q6WKZ4
STSKLSLPMFTVLRK	SLC35D2	111	Q76EJ3
SLSSPRSKAKSRLSL	SRRM2	761	Q9UQ35
LERSSPLKKITRGMT	TBR1	46	Q16650
RLPALSSRKMDISKT	NCKAP5	1516	O14513
SLPSMIRKIFATLTR	RIF1	846	Q5UIP0
SRKSRSLEKRMLIPS	TMEM184A	396	Q6ZMB5
KSPLSVRSTDMIRLK	PNMA5	276	Q96PV4
AKRRLMTLTKPSREA	RAPGEF2	381	Q9Y4G8
SKKMSTDRKRPSFTL	ZNF540	146	Q8NDQ6
KDSPLRTLKRKSSNM	SUN2	36	Q9UH99
IPLESLRTKALSMLT	RYR3	1686	Q15413
KRSSPETLISDLLMR	NPY	66	P01303
LTKMESTALLRTLPR	nan	36	Q9UF83
TMKSLKKDSRLRITP	MYCBPAP	6	Q8TBZ2
QSMSSLPSSKLIRIL	SMC6	1051	Q96SB8
RTSFPLMRSKSLQLT	SUCO	1071	Q9UBS9
KKLSASSPRMLHRST	ZMYND11	441	Q15326
MRLAKPKAGISRSSS	ZNF22	1	P17026
SIISMLSSCKEKRRP	UBE2W	111	Q96B02
STALRSSPIMRKKVS	PPIP5K2	1166	O43314
RSMSRKVTTNKLLLS	VTI1B	196	Q9UEU0
LLSSRNMSSRKKSPA	ZBED4	106	O75132
YTQSPMKKLTTLSRR	LIPK	206	Q5VXJ0