Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent activity	HSP90B1 MCM8 CENPE ATP13A1 MYO9B DDX52 CCT7 MORC2 DNAH7 DNAH1 BLM BPTF SLFN13 ABCB11 MACF1 SLFN11 ACSM2A ACSM2B	2.43e-06	614	161	18	GO:0140657
GeneOntologyMolecularFunction	ATP hydrolysis activity	HSP90B1 MCM8 ATP13A1 MYO9B DDX52 CCT7 MORC2 DNAH7 BLM SLFN13 ABCB11 MACF1 SLFN11	6.16e-05	441	161	13	GO:0016887
GeneOntologyMolecularFunction	benzoate-CoA ligase activity	ACSM2A ACSM2B	1.93e-04	3	161	2	GO:0018858
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	PUS3 CMTR1 MCM8 DDX52 REV3L TRMT2B POLR3A FAN1 BLM DUS2 BPTF DCLRE1C SLFN13 SLFN11 EXOSC7	2.35e-04	645	161	15	GO:0140640
GeneOntologyMolecularFunction	decanoate-CoA ligase activity	ACSM2A ACSM2B	3.84e-04	4	161	2	GO:0102391
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DOCK3 HSP90B1 ATP13A1 USP11 LONRF1 UBR4 MRPS35 CCT7 HUWE1 ACTR3B REV3L UBASH3A CPNE5 INTS8 FAN1 RCBTB1 PRKAR1A MACF1 ASTN2 TLN2 ATIC ATM GFPT2 ARHGAP21 AGTPBP1	4.24e-09	1285	170	25	35914814
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DOCK3 KCTD12 KNTC1 GBF1 CMTR1 ATP13A1 RC3H1 MORC2 FAN1 PARP4 SETD2 MACF1 ASTN2 SSH2 MGA	2.36e-08	493	170	15	15368895
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	BDP1 KNTC1 CENPE MYO9B USP11 HUWE1 NCKAP5L RUFY1 BLM SETD2 NFATC3 BANP MACF1 SLFN11 ZMYM6	2.31e-07	588	170	15	38580884
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	ASXL1 GBF1 HK3 CMTR1 MYO9B USP11 DDX52 UBR4 APOA2 HUWE1 REV3L MORC2 BLM BPTF RCBTB1 BANP MGA AGTPBP1	2.45e-07	857	170	18	25609649
Pubmed	Defining the membrane proteome of NK cells.	HSP90B1 GBF1 CHERP DRG2 CENPE MED16 ATP13A1 MYO9B DDX52 UBR4 LPCAT4 DGKA RHOT2 HUWE1 POLR3A PARP4 PRKAR1A ATIC LAS1L KDSR	1.26e-06	1168	170	20	19946888
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	KCTD12 KNTC1 HSP90B1 GBF1 CHERP ATP13A1 DDX52 UBR4 MRPS35 DUOX2 CCT7 APOB HUWE1 F2 POLR3A DFFA TGM3 PRKAR1A CSTF3 TLN2 ATIC ATM	1.95e-06	1425	170	22	30948266
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	CENPE UBR4 HUWE1 NCKAP5L DNAH7 ANKRD30A GFPT2 SDK1	2.07e-06	170	170	8	23314748
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DOCK3 KCTD12 GBF1 ATP13A1 MYO9B LONRF1 SPEG MAEA UBR4 SLC10A3 ICE1 RHOT2 HUWE1 REV3L TLNRD1 BANP NPRL3 TLN2 ARHGAP21	2.22e-06	1105	170	19	35748872
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	MCM8 ARRDC4 USP11 DDX52 LPCAT4 L1TD1 RHOT2 REV3L NCKAP5L BPTF SETD2 ACTL8 PCDH19 ASS1 MACF1 SLFN11 TRAF3IP3 MGA AGTPBP1	2.56e-06	1116	170	19	31753913
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	L1TD1 ICE1 SFMBT2 BPTF SETD2 PHF3 LAS1L MGA	2.79e-06	177	170	8	26206133
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	MED16 USP11 UBR4 CCT7 MORC2 POLR3A BLM BPTF S100A11 DFFA SETD2 PAPOLA PHF3 ASS1 CSTF3 ATIC ATM	1.09e-05	1014	170	17	32416067
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	MAEA UBR4 MRPS35 MSL1 SETD2 PRKAR1A MACF1 SLFN11 LAS1L	1.13e-05	282	170	9	23667531
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	DOCK3 GBF1 CENPE UBR4 ICE1 PKD1L2 SFMBT2 PHF3 MACF1 TLN2	1.25e-05	361	170	10	26167880
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	KNTC1 CHERP DRG2 CENPE ATP13A1 ICE1 HUWE1 NCKAP5L SETD2 PHF3 BANP ATIC MGA AGTPBP1	1.64e-05	733	170	14	34672954
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CHERP USP11 DDX52 UBR4 HUWE1 BLM BPTF TGM3 PHF3 MACF1 ATIC ATM LAS1L	2.16e-05	653	170	13	22586326
Pubmed	Factor XIa and Thrombin Generation Are Elevated in Patients with Acute Coronary Syndrome and Predict Recurrent Cardiovascular Events.	F2 F11	2.38e-05	2	170	2	27419389
Pubmed	Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation.	F2 F11	2.38e-05	2	170	2	36724509
Pubmed	Ratio of Apolipoprotein A-II/B Improves Risk Prediction of Postoperative Survival After Carotid Endarterectomy.	APOA2 APOB	2.38e-05	2	170	2	25953375
Pubmed	Factor XI-dependent reciprocal thrombin generation consolidates blood coagulation when tissue factor is not available.	F2 F11	2.38e-05	2	170	2	15072993
Pubmed	Comparative analyses of disease risk genes belonging to the acyl-CoA synthetase medium-chain (ACSM) family in human liver and cell lines.	ACSM2A ACSM2B	2.38e-05	2	170	2	19634011
Pubmed	Activation of factor XI by products of prothrombin activation.	F2 F11	2.38e-05	2	170	2	21527525
Pubmed	The role of high molecular weight kininogen and prothrombin as cofactors in the binding of factor XI A3 domain to the platelet surface.	F2 F11	2.38e-05	2	170	2	10823824
Pubmed	ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2.	DCLRE1C ATM	2.38e-05	2	170	2	19779458
Pubmed	High expression of CPNE5 and CPNE9 predicts positive prognosis in multiple myeloma.	CPNE9 CPNE5	2.38e-05	2	170	2	33780365
Pubmed	The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population.	ACSM2A ACSM2B	2.38e-05	2	170	2	16521160
Pubmed	Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM.	BLM ATM	2.38e-05	2	170	2	12034743
Pubmed	Artemis-dependent DNA double-strand break formation at stalled replication forks.	DCLRE1C ATM	2.38e-05	2	170	2	23465063
Pubmed	Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B.	ACSM2A ACSM2B	2.38e-05	2	170	2	29948332
Pubmed	Metabolism of apolipoprotein A-II containing triglyceride rich ApoB lipoproteins in humans.	APOA2 APOB	2.38e-05	2	170	2	26071654
Pubmed	Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.	SLFN13 SLFN11	2.38e-05	2	170	2	37833372
Pubmed	Protein kinase A subunit expression is altered in Bloom syndrome fibroblasts and the BLM protein is increased in adrenocortical hyperplasias: inverse findings for BLM and PRKAR1A.	BLM PRKAR1A	2.38e-05	2	170	2	18401830
Pubmed	Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase.	DCLRE1C ATM	2.38e-05	2	170	2	22730303
Pubmed	Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair.	DCLRE1C ATM	2.38e-05	2	170	2	21596788
Pubmed	CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM.	ATM PLEKHO1	2.38e-05	2	170	2	16325375
Pubmed	Mitosis. Microtubule detyrosination guides chromosomes during mitosis.	CENPE TTL	2.38e-05	2	170	2	25908662
Pubmed	Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.	SLFN13 SLFN11	2.38e-05	2	170	2	29563550
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	KNTC1 HSP90B1 MYLK PDGFA PCDHGA4 DDX52 UBR4 LPCAT4 DGKA MRPS35 DUOX2 MSL1 APOB SFMBT2 BPTF PKHD1 ANKRD30A MACF1 ATM ARHGAP21	2.77e-05	1442	170	20	35575683
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	PUS3 CCT7 APOB HUWE1 RUFY1 DNAH7 BLM SEC24D SLFN13 MGA CLEC16A SDK1 ARHGAP21 CDON	3.10e-05	777	170	14	35844135
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	HSP90B1 CHERP CCT7 HUWE1 INTS8 BLM PARP4 CSTF3 MACF1 TLN2 ATM LAS1L	3.21e-05	582	170	12	20467437
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ASXL1 SPEG PHF3 PCDH19 MACF1 KATNIP CLEC16A ARHGAP21 VPS13B AGTPBP1	3.48e-05	407	170	10	12693553
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	BDP1 CENPE SPEG APOA2 MORC2 F2 RUFY1 BLM ASS1 ATM ARHGAP21	3.65e-05	497	170	11	36774506
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	HSP90B1 GBF1 HEATR4 SRRM4 INSRR APOB DNAH7 BPTF CSTF3 AGTPBP1	4.53e-05	420	170	10	28065597
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	MED16 USP11 CCT7 HUWE1 BLM SETD2 PHF3 GFPT2 LAS1L EXOSC7	6.67e-05	440	170	10	34244565
Pubmed	Genetic heterogeneity of plasma lipoproteins in the mouse: control of low density lipoprotein particle sizes by genetic factors.	APOA2 APOB	7.10e-05	3	170	2	1971301
Pubmed	Factor XI activation in a revised model of blood coagulation.	F2 F11	7.10e-05	3	170	2	1652157
Pubmed	Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination.	DCLRE1C ATM	7.10e-05	3	170	2	23836881
Pubmed	USP37 regulates DNA damage response through stabilizing and deubiquitinating BLM.	BLM ATM	7.10e-05	3	170	2	34606619
Pubmed	Expression of mucin 3 and mucin 5AC in arthritic synovial tissue.	MUC3B MUC5AC	7.10e-05	3	170	2	18163520
Pubmed	Thrombin-induced cell proliferation and platelet-derived growth factor-AB release from A172 human glioblastoma cells.	PDGFA F2	7.10e-05	3	170	2	17958740
Pubmed	Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA.	SLFN13 SLFN11	7.10e-05	3	170	2	38875319
Pubmed	A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis.	DCLRE1C ATM	7.10e-05	3	170	2	21147755
Pubmed	GBF1 and Arf1 interact with Miro and regulate mitochondrial positioning within cells.	GBF1 RHOT2	7.10e-05	3	170	2	30459446
Pubmed	Taking the next step forward - Diagnosing inherited infantile cholestatic disorders with next generation sequencing.	PKHD1 ABCB11	7.10e-05	3	170	2	25771912
Pubmed	The risk for developing cancer in Israeli ATM, BLM, and FANCC heterozygous mutation carriers.	BLM ATM	7.10e-05	3	170	2	26778106
Pubmed	LINE1 contributes to autoimmunity through both RIG-I- and MDA5-mediated RNA sensing pathways.	L1TD1 MGA	7.10e-05	3	170	2	29525183
Pubmed	Association of common genetic variations and idiopathic venous thromboembolism. Results from EDITh, a hospital-based case-control study.	F2 F11	7.10e-05	3	170	2	20352152
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	HSP90B1 CMTR1 CCT7 MORC2 PHF3 PKHD1 TLN2	7.80e-05	208	170	7	33230847
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	KCTD12 DRG2 CENPE UBR4 HUWE1 PEX5L NFATC3 PRKAR1A MACF1 TLN2 SSH2 MGA TNR ARHGAP21 WNK3	8.35e-05	963	170	15	28671696
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	MSL1 ICE1 RHOT2 BLM SETD2 ZBTB25 PHF3 CSTF3 ATM MGA	8.48e-05	453	170	10	29656893
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	KCTD12 KNTC1 HSP90B1 GBF1 DRG2 USP11 MAEA UBR4 CCT7 HUWE1 RUFY1 DFFA SEC24D MYG1 PAPOLA ASS1 PRKAR1A MACF1 ATIC	9.86e-05	1455	170	19	22863883
Pubmed	Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain.	UBR1 UBR4 CCT7 HUWE1	1.06e-04	50	170	4	17550899
Pubmed	A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors.	HSP90B1 GBF1 CCT7 ATM	1.06e-04	50	170	4	23703321
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	SPEG UBR4 DNAH1 PCDH19 ARHGAP21 ZMYM6	1.11e-04	153	170	6	10718198
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	UBR1 GBF1 HUWE1 MORC2 BLM BPTF S100A11 SETD2 PAPOLA PHF3 TLN2 ATM AGTPBP1	1.21e-04	774	170	13	15302935
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	UBR1 HSP90B1 MYO9B USP11 DDX52 UBR4 CCT7 RHOT2 HUWE1 ARMCX1 POLR3A BLM TGM3 ASS1 MACF1 ATIC LAS1L MGA	1.21e-04	1353	170	18	29467282
Pubmed	The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.	MYLK NEK10 LONRF1 MSL1 HUWE1 DFFA MYG1	1.27e-04	225	170	7	25277244
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	ASXL1 GBF1 PHF3 MACF1 TLN2 CLEC16A DAGLA	1.27e-04	225	170	7	12168954
Pubmed	The common viral insertion site Evi12 is located in the 5'-noncoding region of Gnn, a novel gene with enhanced expression in two subclasses of human acute myeloid leukemia.	HSP90B1 TTC41P	1.42e-04	4	170	2	15827139
Pubmed	A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.	UBR1 UBR4	1.42e-04	4	170	2	16055722
Pubmed	ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation.	HUWE1 ATM	1.42e-04	4	170	2	26711340
Pubmed	Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice.	APOB ATM	1.42e-04	4	170	2	15863839
Pubmed	TRIM26 promotes non-small cell lung cancer survival by inducing PBX1 degradation.	UBR4 HUWE1	1.42e-04	4	170	2	37324936
Pubmed	Endogenous gamma-H2AX-ATM-Chk2 checkpoint activation in Bloom's syndrome helicase deficient cells is related to DNA replication arrested forks.	BLM ATM	1.42e-04	4	170	2	17634426
Pubmed	FANCD2-controlled chromatin access of the Fanconi-associated nuclease FAN1 is crucial for the recovery of stalled replication forks.	FAN1 BLM	1.42e-04	4	170	2	25135477
Pubmed	A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.	DCLRE1C ATM	1.42e-04	4	170	2	15574327
Pubmed	ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation.	BLM ATM	1.42e-04	4	170	2	15539948
Pubmed	Nox4 and Duox1/2 Mediate Redox Activation of Mesenchymal Cell Migration by PDGF.	PDGFA DUOX2	1.42e-04	4	170	2	27110716
Pubmed	The substrate recognition domains of the N-end rule pathway.	UBR1 UBR4	1.42e-04	4	170	2	19008229
Pubmed	Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B.	DCLRE1C ATM	1.42e-04	4	170	2	17242184
Pubmed	Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells.	ACSM2A ACSM2B	1.42e-04	4	170	2	32830538
Pubmed	The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.	HUWE1 ATM	1.42e-04	4	170	2	22213803
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	HUWE1 CPNE5 NCKAP5L SFMBT2 WNK3	1.43e-04	101	170	5	10997877
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	CHERP ARRDC4 USP11 DDX52 UBR4 HUWE1 PRKAR1A ATM	1.63e-04	313	170	8	38270169
Pubmed	Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.	F2 CLEC16A L3MBTL4	1.65e-04	22	170	3	20694011
Pubmed	Functional proteomics mapping of a human signaling pathway.	UBR4 L1TD1 RHOT2 HUWE1 SEC24D MYG1 PAPOLA PRKAR1A MACF1 MGA SDK1	1.69e-04	591	170	11	15231748
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	ASXL1 CCT7 FBXW2 MSL1 BPTF S100A11 TGM3 LAS1L MGA L3MBTL4	1.74e-04	495	170	10	27705803
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	MAEA MRPS35 APOB HUWE1 DNAH1 SETD2 PRKAR1A MACF1 EXOSC7 AGTPBP1	1.77e-04	496	170	10	31343991
Pubmed	Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease.	APOA2 APOB ABCB11 KDSR	2.03e-04	59	170	4	20855565
Pubmed	Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma.	MTF1 ATM	2.35e-04	5	170	2	19286843
Pubmed	Subcellular localization of the Schlafen protein family.	SLFN13 SLFN11	2.35e-04	5	170	2	18355440
Pubmed	Primary Ciliary Dyskinesia Associated Disease-Causing Variants in CCDC39 and CCDC40 Cause Axonemal Absence of Inner Dynein Arm Heavy Chains DNAH1, DNAH6, and DNAH7.	DNAH7 DNAH1	2.35e-04	5	170	2	39056782
Pubmed	Identification of disulfide-linked apolipoprotein species in human lipoproteins.	APOA2 APOB	2.35e-04	5	170	2	8245722
Pubmed	Expression and regulatory effects of murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma.	SLFN13 SLFN11	2.35e-04	5	170	2	24089532
Pubmed	Apixaban, a direct factor Xa inhibitor, inhibits tissue-factor induced human platelet aggregation in vitro: comparison with direct inhibitors of factor VIIa, XIa and thrombin.	F2 F11	2.35e-04	5	170	2	20589316
Pubmed	Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis.	SLFN13 SLFN11	2.35e-04	5	170	2	29528433
Pubmed	DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination.	DCLRE1C ATM	2.35e-04	5	170	2	18316419
Pubmed	[Assessment of five thrombophilic genetic polymorphisms among couples with habitual abortion].	F2 KDSR	2.35e-04	5	170	2	16711541
Pubmed	DNA double strand break repair enzymes function at multiple steps in retroviral infection.	DCLRE1C ATM	2.35e-04	5	170	2	20003485
Pubmed	Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA.	CHERP MYO9B	2.35e-04	5	170	2	10729222
Pubmed	Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.	PRKAR1A ACSM2A ACSM2B	2.44e-04	25	170	3	19372376
GeneFamily	Fibronectin type III domain containing	MYLK INSRR PTPRM ASTN2 TNR SDK1 CDON	4.92e-05	160	108	7	555
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR1 UBR4	7.28e-04	7	108	2	785
GeneFamily	Schlafen family	SLFN13 SLFN11	7.28e-04	7	108	2	1110
GeneFamily	Copines	CPNE9 CPNE5	1.24e-03	9	108	2	829
GeneFamily	Sterile alpha motif domain containing\|MBT domain containing	SFMBT2 L3MBTL4	1.24e-03	9	108	2	1263
GeneFamily	EF-hand domain containing	DGKA DUOX2 RHOT2 DNAH7 S100A11 MACF1	2.02e-03	219	108	6	863
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	MYLK SPEG PTPRM SDK1 CDON	2.81e-03	161	108	5	593
GeneFamily	Tubulin tyrosine ligase family	TTLL2 TTL	3.07e-03	14	108	2	779
GeneFamily	Chaperonins	MKKS CCT7	3.53e-03	15	108	2	587
GeneFamily	Dyneins, axonemal	DNAH7 DNAH1	4.53e-03	17	108	2	536
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	BDP1 UBR1 CDK17 MYO9B ANKRD10 UBR4 DGKA FBXW2 ICE1 HUWE1 REV3L UBASH3A SFMBT2 BPTF SETD2 PAPOLA NFATC3 PHF3 PRKAR1A MACF1 SLFN11 TRAF3IP3 ATM SSH2 PLEKHO1 VPS13B	3.24e-06	1492	168	26	M40023
Coexpression	LAKE_ADULT_KIDNEY_C4_PROXIMAL_TUBULE_EPITHELIAL_CELLS_S2	BDP1 PTPRM PKHD1 SSH2 ACSM2A SDK1 ACSM2B L3MBTL4	1.88e-05	176	168	8	M39223
Coexpression	GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP	KNTC1 ASXL1 GBF1 MYO9B BPTF SETD2 MACF1 ATM	2.21e-05	180	168	8	M8239
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRM PKHD1 MACF1 SSH2 ACSM2A SDK1 VPS13B ACSM2B L3MBTL4	5.39e-08	192	169	9	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOCK3 DUOX2 SFMBT2 TGM3 PKHD1 ABCB11 ACSM2B L3MBTL4	2.03e-07	162	169	8	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BDP1 CDK17 BPTF SLFN13 PHF3 MACF1 ATM VPS13B	9.66e-07	199	169	8	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KCTD12 DRG2 CENPE POLR3A MACF1 ASTN2 MGA	5.42e-06	178	169	7	c87945146b2734141f07b39d268e0d8086ee0364
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SRRM4 APOB PKD1L2 DNAH1 PKHD1 TLN2 SDK1	6.73e-06	184	169	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SRRM4 APOB PKD1L2 DNAH1 PKHD1 TLN2 SDK1	6.73e-06	184	169	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SRRM4 APOB PKD1L2 DNAH1 PKHD1 TLN2 SDK1	6.73e-06	184	169	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ASS1 PKHD1 TLN2 ACSM2A SDK1 ACSM2B L3MBTL4	8.59e-06	191	169	7	3c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ASS1 PKHD1 TLN2 ACSM2A SDK1 ACSM2B L3MBTL4	8.59e-06	191	169	7	1c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DNAH7 FRK PKHD1 ASTN2 ACSM2A ACSM2B L3MBTL4	9.19e-06	193	169	7	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FRK PKHD1 ASTN2 ACSM2A SDK1 ACSM2B L3MBTL4	9.51e-06	194	169	7	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK3 PKHD1 ABCB11 EDDM13 ACSM2B L3MBTL4	1.94e-05	145	169	6	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1\|343B / Donor, Lineage, Cell class and subclass (all cells)	THNSL1 ACTR3B UBASH3A CPNE5 ATM MUC5AC	2.26e-05	149	169	6	2a7f71da51c85e04de2123164914122480e60d66
ToppCell	COVID-19-lung-Mesothelial\|lung / Disease (COVID-19 only), tissue and cell type	LYPD6 SPEG PEX5L CPNE5 GFPT2 CDON	2.93e-05	156	169	6	e1f563869b3bf997eaa2e756e31b53db1a478903
ToppCell	15-Airway-Mesenchymal-Airway_Smooth_Muscle\|Airway / Age, Tissue, Lineage and Cell class	DOCK3 MYLK SPEG SRRM4 CPNE5 L3MBTL4	4.01e-05	165	169	6	531804467601e1ee1f771cffa21501f6d464ae10
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	CHERP RC3H1 SETD2 NFATC3 KATNIP MGA	4.15e-05	166	169	6	32d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell	droplet-Lung-nan-3m-Lymphocytic-Regulatory_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACTR3B UBASH3A ANKRD55 ASS1 NPRL3 TRAF3IP3	4.44e-05	168	169	6	1df3c8c7a6dceb901805eaba7f86f9943f4f1a9d
ToppCell	droplet-Lung-nan-3m-Lymphocytic-regulatory_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACTR3B UBASH3A ANKRD55 ASS1 NPRL3 TRAF3IP3	4.44e-05	168	169	6	1586451d437b70b2dffe41d782b694702dcaf50b
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-regulatory_T_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ACTR3B UBASH3A ANKRD55 ASS1 NPRL3 TRAF3IP3	5.06e-05	172	169	6	425970e9ce8943f7e2ba6ca958e7a3a29baa798c
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ACTR3B UBASH3A ANKRD55 ASS1 NPRL3 TRAF3IP3	5.06e-05	172	169	6	ca0cc0e92b6cdce5016f18fcb2ec1508cb222502
ToppCell	TCGA-Liver\|World / Sample_Type by Project: Shred V9	APOA2 APOB F2 F11 CFHR4 ABCB11	5.39e-05	174	169	6	452932f08cf53e5949672a025d78cecb874aa4b0
ToppCell	TCGA-Colorectal-Recurrent_Tumor\|TCGA-Colorectal / Sample_Type by Project: Shred V9	F2 F11 CFHR4 CYP4F22 ACSM2A ACSM2B	5.57e-05	175	169	6	7f74961436f88c0e380819095e6104489914d765
ToppCell	TCGA-Colorectal-Recurrent_Tumor-Colorectal_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	F2 F11 CFHR4 CYP4F22 ACSM2A ACSM2B	5.57e-05	175	169	6	bee8f31f036dfcf9fc6ed29156554771a9ee3c60
ToppCell	COVID-19-kidney-PCT-S3-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	APOA2 APOB F2 F11 ABCB11 ACSM2B	5.75e-05	176	169	6	b6497324e3e52f514ce556a3fa0c3011c45dcc7b
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NEK10 DNAH7 DNAH1 WDR97 SLFN13 MDH1B	6.12e-05	178	169	6	3b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MKKS PCDHGA4 DNAH1 BLM ASS1 KCTD14	6.31e-05	179	169	6	b44e2d53b82c3c141bfc6539054b19708200a0d9
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-myocytic-myofibroblast\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYLK SPEGNB NPIPA7 PCDH19 MDH1B RSPO2	6.71e-05	181	169	6	fc51468c74534b60b4e786bd512d0f1c5dc05de7
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PUS3 CENPE LPCAT4 TTL GFPT2 LINC02694	7.13e-05	183	169	6	f142b320023eef00b48d4820c46214c9794d37e7
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-5_PVALB_TRIM67\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PKD1L2 SFMBT2 BLM PTPRM PKHD1 L3MBTL4	7.35e-05	184	169	6	7f6c8912677764d438ab0555faca344d74c2f483
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ASS1 PKHD1 TLN2 ACSM2A ACSM2B L3MBTL4	7.80e-05	186	169	6	5784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	UBR1 KLHL24 MYLK PARP4 NFATC3 VPS13B	7.80e-05	186	169	6	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	COVID-19-kidney-Mito-rich_PCT\|kidney / Disease (COVID-19 only), tissue and cell type	ASS1 PKHD1 ASTN2 ACSM2A ACSM2B L3MBTL4	8.03e-05	187	169	6	738ec2611b4be6a08eedad16b57fba84e1f11fef
ToppCell	COVID-19-kidney-PCT-S2\|kidney / Disease (COVID-19 only), tissue and cell type	PKHD1 ASTN2 ACSM2A SDK1 ACSM2B L3MBTL4	8.52e-05	189	169	6	0be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCell	pdx-Tumor_cells-T8\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	F11 ASS1 ABCB11 ACSM2A ACSM2B L3MBTL4	8.77e-05	190	169	6	b05db0de9b6ae01dd30074453f7de44f7397631e
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LYPD6 PTPRM ASS1 RSPO2 ASTN2 SDK1	8.77e-05	190	169	6	305fbef734c350cfbf786ca7ff6e07093aab56ea
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	KNTC1 UBR1 GBF1 HUWE1 MACF1 AGTPBP1	9.02e-05	191	169	6	9454f642c3621370fa23640b631301346b300950
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYLK PKHD1 ACSM2A SDK1 ACSM2B L3MBTL4	9.02e-05	191	169	6	1cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK3 MYLK NEK10 PKHD1 ASTN2 CLEC16A	9.02e-05	191	169	6	9032aa974aa1b7b1095b8d1b58dcb087358a5001
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK3 MYLK NEK10 PKHD1 ASTN2 CLEC16A	9.02e-05	191	169	6	5717809a1476c20f65bce722c5a57cff92ee0d7a
ToppCell	human_hepatoblastoma-Tumor_cells-T8\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	F11 ASS1 ABCB11 ACSM2A ACSM2B L3MBTL4	9.29e-05	192	169	6	e785135262f4c9cc66c403bf362bb34643b212c5
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LYPD6 ANKRD55 BLM PTPRM ASS1 ASTN2	9.55e-05	193	169	6	4979862c0c16e6b4baa4c79894f1d237c861f5a5
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LYPD6 ANKRD55 BLM PTPRM RSPO2 ASTN2	9.55e-05	193	169	6	53bcd50892c379b2a571751f6eb1062436339fe7
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LYPD6 BLM PTPRM ASS1 ASTN2 SDK1	9.55e-05	193	169	6	c4b22b62f3cc7bf0ec0eba76e1504c236290bbc9
ToppCell	Parenchymal-NucSeq-Stromal-Mesofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LYPD6 PRSS38 SPEG PEX5L CPNE5 GFPT2	1.01e-04	195	169	6	a52685f76eca269a7d2de8dfc317439483e233fa
ToppCell	(1)_T_cells-(1)_T_CD4_naive\|(1)_T_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)	DGKA ANKRD55 BPTF SETD2 PHF3 ATM	1.01e-04	195	169	6	d3fa551bc6f5ee5890af1040415e61ecd5d46201
ToppCell	Parenchymal-NucSeq-Stromal-Mesofibroblastic-Mesothelia\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LYPD6 PRSS38 SPEG PEX5L CPNE5 GFPT2	1.01e-04	195	169	6	224deeba2f60def6543a55bb4f5ee6c7fdab3f02
ToppCell	Control-Neu_4\|Control / 5 Neutrophil clusters in COVID-19 patients	BDP1 HSP90B1 GBF1 MCM8 CENPE MGA	1.04e-04	196	169	6	b8b7b54ca17a08fa775507bb22b1c7248ada8f40
ToppCell	LPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	NEK10 DUOX2 NME9 DNAH7 DNAH1 MDH1B	1.16e-04	200	169	6	96701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Pericyte-Pericyte_3\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	MYLK TMEM61 PDGFA SPEGNB EGFL6 CORO6	1.16e-04	200	169	6	9169a9ec8e9ab95d90a64c5a19ac666a5cf82313
ToppCell	mLN-Macrophage-LYVE1_Macrophage\|Macrophage / Region, Cell class and subclass	HSP90B1 ATP13A1 MRPS35 CCT7 INTS8 BPTF	1.16e-04	200	169	6	e3c15e0e1c2602b0cc9ab8cc50c978d265350c94
ToppCell	LPS_IL1RA-Epithelial_airway-airway_epithelial-Ciliated\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	NEK10 DUOX2 NME9 DNAH7 DNAH1 MDH1B	1.16e-04	200	169	6	4992dbf0514d674017315dbd20d91dfec0c608e9
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BDP1 BPTF SETD2 PHF3 MACF1 ATM	1.16e-04	200	169	6	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	LYPD6 ANKRD55 BLM PTPRM RSPO2 ASTN2	1.16e-04	200	169	6	107854f4855fc99c9f7e737eb246f0d868e6c5fd
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_3\|LPS_only / Treatment groups by lineage, cell group, cell type	MYLK TMEM61 PDGFA SPEGNB EGFL6 AMER2	1.16e-04	200	169	6	7c62678cf408aaaf98d6df0fb27814d2007c4521
Computational	Genes upregulated in subsets of cells of a given type within various tumors	BDP1 BPTF PHF3 MACF1 ATM	7.15e-05	49	96	5	GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_CHROMATIN
Drug	0179445-0000 [211246-22-9]; Down 200; 10uM; MCF7; HT_HG-U133A	ANKRD10 MORC2 BLM BPTF BANP PTCD2 CSTF3 KATNIP ATM VPS13B	1.03e-06	185	165	10	4755_DN
Drug	Helveticoside [630-64-8]; Down 200; 7.4uM; MCF7; HT_HG-U133A	MKKS THNSL1 MORC2 ARMCX1 DUS2 ACTL8 PTCD2 ASTN2 PLEKHO1	8.95e-06	186	165	9	3851_DN
Drug	Digitoxigenin [143-62-4]; Down 200; 10.6uM; MCF7; HT_HG-U133A	MKKS THNSL1 PDGFA MORC2 ARMCX1 DUS2 PTCD2 MACF1 ASTN2	1.15e-05	192	165	9	4801_DN
Drug	Naltrexone hydrochloride dihydrate [16676-29-2]; Down 200; 9.6uM; HL60; HG-U133A	DRG2 GIN1 MYO9B TRMT2B DUS2 NFATC3 MTF1 ATM EXOSC7	1.20e-05	193	165	9	1363_DN
Disease	X-21319 measurement	ACSM2A ACSM2B	3.03e-05	2	163	2	EFO_0800807
Disease	X-11478 measurement	ACSM2A ACSM2B	9.07e-05	3	163	2	EFO_0021242
Disease	Uterine leiomyoma, estrogen-receptor positive breast cancer	MCM8 NEK10 ASTN2	1.27e-04	18	163	3	EFO_1000649, HP_0000131
Disease	endoplasmin measurement	HSP90B1 TTC41P	1.81e-04	4	163	2	EFO_0801570
Disease	total blood protein measurement	TTC41P ANKRD55 DNAH1 FRK SETD2 NFATC3 RCBTB1 PKHD1 MACF1 CLEC16A	2.10e-04	449	163	10	EFO_0004536
Disease	3-hydroxyhexanoate measurement	ACSM2A ACSM2B	3.00e-04	5	163	2	EFO_0800378
Disease	indoleacetoylcarnitine measurement	ACSM2A ACSM2B	4.48e-04	6	163	2	EFO_0800106
Disease	familial combined hyperlipidemia (is_marker_for)	APOA2 APOB	4.48e-04	6	163	2	DOID:13809 (is_marker_for)
Disease	glucose metabolism disease (implicated_via_orthology)	HK3 INSRR DGKA	4.90e-04	28	163	3	DOID:4194 (implicated_via_orthology)
Disease	sugar consumption measurement	PKHD1 PRKAR1A RSPO2 VPS13B L3MBTL4	5.53e-04	120	163	5	EFO_0010158
Disease	Ovarian Mucinous Adenocarcinoma	MYLK NEK10 SPEG	6.64e-04	31	163	3	C1335167
Disease	Familial hypercholesterolemia	APOA2 APOB	8.31e-04	8	163	2	cv:C0020445
Disease	common bile duct neoplasm (is_marker_for)	APOB MUC5AC	8.31e-04	8	163	2	DOID:4608 (is_marker_for)
Disease	Intellectual Disability	PUS3 BPTF SETD2 MTF1 ASS1 MACF1 ATIC LAS1L ZMYM6	8.91e-04	447	163	9	C3714756
Disease	celiac disease (is_implicated_in)	MYO9B F2	1.33e-03	10	163	2	DOID:10608 (is_implicated_in)
Disease	polybrominated biphenyl measurement, gestational serum measurement, fetal genotype effect measurement, polybrominated diphenyl ether measurement	PEX5L PTPRM	1.61e-03	11	163	2	EFO_0007959, EFO_0007961, EFO_0007962, EFO_0007964
Disease	phospholipids:total lipids ratio	APOA2 APOB DUS2 BPTF PRKAR1A MACF1	1.69e-03	227	163	6	EFO_0020946
Disease	response to angiotensin-converting enzyme inhibitor, Cough	ACTR3B PKD1L2 VPS13B	2.11e-03	46	163	3	EFO_0005325, HP_0012735
Disease	Hyperlipoproteinemia Type IIb	APOA2 APOB	2.27e-03	13	163	2	C1704417
Disease	Adenoid Cystic Carcinoma	INSRR SETD2 ATM MGA	2.33e-03	100	163	4	C0010606
Disease	cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement	APOA2 APOB DNAH1 DUS2 BPTF MACF1	2.38e-03	243	163	6	EFO_0004612, EFO_0020944
Disease	apolipoprotein A 1 measurement	CMTR1 ANKRD10 APOB DUS2 FRK NFATC3 BANP PTCD2 ABCB11 MACF1 MGA PLEKHO1	2.74e-03	848	163	12	EFO_0004614
Disease	free cholesterol to total lipids in small HDL percentage	APOA2 APOB PRKAR1A	2.84e-03	51	163	3	EFO_0022285
Disease	thrombosis (is_implicated_in)	F2 F11	3.04e-03	15	163	2	DOID:0060903 (is_implicated_in)
Disease	bilirubin measurement	UBR1 MYO9B APOB REV3L PKD1L2 MTF1 ASTN2 L3MBTL4	3.29e-03	442	163	8	EFO_0004570
Disease	Hyperlipoproteinemia Type IIa	APOA2 APOB	3.46e-03	16	163	2	C0745103
Disease	non-alcoholic fatty liver disease	DRG2 POLR3A BPTF ACSM2A ACSM2B	3.48e-03	182	163	5	EFO_0003095
Disease	leukemia	BLM SETD2 ATM	3.52e-03	55	163	3	C0023418
Disease	spinal stenosis	MRPS35 ASTN2	3.91e-03	17	163	2	EFO_0007490
Disease	alkaline phosphatase measurement	ELP5 ATP13A1 C8orf74 APOB CFHR4 DUS2 FRK NFATC3 PTCD2 PRKAR1A ABCB11 MACF1 ARHGAP21	4.29e-03	1015	163	13	EFO_0004533
Disease	glucose homeostasis measurement, acute insulin response measurement	PTPRM ASTN2	4.38e-03	18	163	2	EFO_0006831, EFO_0006896
Disease	Hypercholesterolemia, Familial	APOA2 APOB	4.38e-03	18	163	2	C0020445
Disease	cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	GBF1 APOA2 APOB DNAH1 BPTF MACF1	4.44e-03	276	163	6	EFO_0004612, EFO_0020943
Disease	Cleft palate, cleft lip	PKHD1 TLN2 TRAF3IP3 LINC02694 SDK1 VPS13B	4.67e-03	279	163	6	EFO_0003959, HP_0000175
Disease	Hereditary Non-Polyposis Colon Cancer Type 2	FAN1 ATM	4.88e-03	19	163	2	C1333991
Disease	Colorectal cancer, hereditary nonpolyposis, type 1	FAN1 ATM	4.88e-03	19	163	2	C2936783
Disease	free cholesterol in very large HDL measurement	APOA2 APOB PRKAR1A	4.93e-03	62	163	3	EFO_0022273

Protein segments in the cluster

Peptide	Gene	Start	Entry
PSIKTICLRLDSIEA	BANP	51	Q8N9N5
LERESISTTPKCFLE	DDX52	561	Q9Y2R4
ESLTVEVLRTKGPCV	BDP1	261	A6H8Y1
TASLECVKEETPRAA	AMER2	231	Q8N7J2
LRCSAIPENSVKEVL	EGFL6	256	Q8IUX8
VRRQAKEPCVESLVS	APOA2	21	P02652
LRETKGCSITEAVTI	C8orf74	76	Q6P047
LCISGTEEPEKTLRA	ANKRD10	326	Q9NXR5
SIPRAIVESVESCEI	ACTL8	271	Q9H568
IVESVESCEISLRPL	ACTL8	276	Q9H568
EVDTVASECPSLRIK	ACSM2A	166	Q08AH3
ASECPSLRIKLLVSE	ACSM2A	171	Q08AH3
VSCPLKADSKAVIRE	ATP13A1	721	Q9HD20
IPSCIAIRESAKVVD	ACTR3B	31	Q9P1U1
ESLRETVSQKDVCVP	ANKRD30A	926	Q9BXX3
TSIFETIDRKPIIDC	ABCB11	391	O95342
TACVKLLSQESRTEP	ANKRD55	311	Q3KP44
ACDILAIDKSLTPVT	DFFA	46	O00273
RVLDDVSIRSPETKC	BPTF	1291	Q12830
CPTSLSVVKDRNLTE	CAVIN4	141	Q5BKX8
TSQECLAVRTLDPLV	AGTPBP1	301	Q9UPW5
VELSINPLASCKTDV	ASTN2	606	O75129
LSTVTLRTACPLVDD	ASTN2	1181	O75129
VSRVCAVRQKIPDSL	ASXL1	1066	Q8IXJ9
TSLARPCIARKQVEI	ASS1	91	P00966
AEIENCSSRLIVPKA	ARRDC4	216	Q8NCT1
ICTQTFDETIRKPIS	RC3H1	16	Q5TC82
TLLSPQEIASIRKAC	RCBTB1	11	Q8NDN9
CLELVTEFSPKLRQV	INTS8	596	Q75QN2
VTICSPKVNSVIREA	PCDH19	1041	Q8TAB3
ISRESCEKSEPLLIT	PCDHGA4	811	Q9Y5G9
LCKSEPLTTERVRTT	MKKS	11	Q9NPJ1
SLCSVSIEKALPEDR	MYLK	1151	Q15746
SLLSIRQDDKVVCPR	MAEA	366	Q7L5Y9
CDLPKVVSRAENLSV	LPCAT4	141	Q643R3
VDLEPVSPRSCLTKV	NCKAP5L	761	Q9HCH0
VSPRSCLTKVELAKS	NCKAP5L	766	Q9HCH0
IATELRDAPEKTLAC	MCM8	141	Q9UJA3
LEPCAVTRSTVKISE	MGA	471	Q8IWI9
SVVDPALRPKTCISE	KATNIP	1596	O60303
IVRTRDPEKLASCDI	MYG1	76	Q9HB07
VSCSSVVLRTLRKPA	LPAR4	221	Q99677
DCLKRVSSEPVLSVQ	LONRF1	406	Q17RB8
TRIIPTDIISDLSEC	DDX58	116	O95786
PLDSSQKVREALTCE	DUOX2	791	Q9NRD8
EKVTDTISRCLTPDA	NEK10	756	Q6ZWH5
CLKLPVAQRRTVSIE	SLC10A3	406	P09131
SIVDSISSEERKLPC	MYF6	221	P23409
LCETKSEAIARPVTS	PEX5L	86	Q8IYB4
CKIPNTVEEAVRIIT	CSTF3	646	Q12996
IDCSPALVRVIKTTS	NPRL3	276	Q12980
ATAKVITDPDILKTC	DGKA	631	P23743
SPRVECVLAELKGVT	LAS1L	301	Q9Y4W2
PKLSEDSVSVLVLRC	KNTC1	376	P50748
VDRKNPSLVCVATIA	L3MBTL4	201	Q8NA19
VCRDITRLPKTVATT	MUC5AC	1676	P98088
APCTAIREVSLLKDL	CDK17	231	Q00537
SRTTPVDLCLLEESV	PARP4	1491	Q9UKK3
LKTRIVFSESVLPVC	PRSS38	156	A1L453
LRESSPKKEETVARC	MSL1	446	Q68DK7
KSSVDLKTLCISPRE	EXOSC7	116	Q15024
VAATVRELAPRCVVT	HK3	881	P52790
QRSSESELCIETPKL	HUWE1	3231	Q7Z6Z7
IVEESIRTCKPAFLS	MACF1	2986	Q9UPN3
CRPVNASKDILLRVT	PKD1L2	671	Q7Z442
PGDRLTEICTKITDV	MED16	576	Q9Y2X0
IAVAEPSTSECLRIE	MORC2	881	Q9Y6X9
ISLAAPKETDCVLTQ	PAPOLA	26	P51003
IEKAVVSQRLTESPC	HSP90B1	631	P14625
LPCLSTEADKSTVIE	FRK	16	P42685
RPEVITALSKVRAEC	DNAH1	506	Q9P2D7
ETECLRIAKPNVSAS	ATM	71	Q13315
RSATRINCKVELEVP	APOB	71	P04114
VPSAIVSCLEEVSAL	ICE1	2246	Q9Y2F5
AAIPIAKRCITAVSL	KLHL24	486	Q6TFL4
VSERLSSAKTDCLPV	BLM	596	P54132
SAESTNILKLCPREE	CASP5	156	P51878
VVEILKPLCRSSQST	DCLRE1C	351	Q96SD1
ESAVLDSIKAQPCRS	DOCK3	1941	Q8IZD9
RPIILCSKDDTESSK	GFPT2	616	O94808
LQPIIDTCTKDAISA	CHERP	161	Q8IWX8
NIIDCFVSRPTEKTI	GJA9	196	P57773
NLVDCFISRPTEKTV	GJB6	176	O95452
LAVLSRSPVTLECVV	CDON	231	Q4KMG0
VPATKIEITVSCRNL	CPNE9	11	Q8IYJ1
CLSRPETTETTEVIK	DNAH7	2191	Q8WXX0
IKAITTCATAALERP	HEATR4	496	Q86WZ0
CVLKDSVTETLPRVN	F11	76	P03951
ATTCKDKTLRIIDPR	CORO6	191	Q6QEF8
AEACTPREVATKEKI	EDDM13	21	A0A1B0GTR0
TVPCLRTCSKSDVEI	CFHR4	81	Q92496
DLASPVLRSVSICTK	MDH1B	186	Q5I0G3
SVTKRCVPLEECLST	LYPD6	91	Q86Y78
TVEVCPSLDIRSEVA	INSRR	26	P14616
ALKTVNELASPRECI	INSRR	1011	P14616
QECLAADKIRTSTPT	DAGLA	1011	Q9Y4D2
ITPDNFELCVKTLRI	GBF1	1406	Q92538
LKDSIVQLCTARPER	PRKAR1A	31	P10644
IDVEIARSDCRKPLS	CST8	86	O60676
CKRTDPVPVTIALDS	ELP5	111	Q8TE02
SCEVIKAIADTLSIP	DUS2	196	Q9NX74
LVETKETCFIREPKT	ESRG	126	Q1W209
KTLSVSEDRSICLQP	FBXW2	316	Q9UKT8
TTLECIASARPVEDL	SDK1	311	Q7Z5N4
RAKVLCLSPESSAEA	SLFN13	511	Q68D06
VTRRCTVVSVPDSLL	KCTD12	46	Q96CX2
KPLETRLISETTSVC	KDSR	231	Q06136
RLISETTSVCKPEQV	KDSR	236	Q06136
KTRIICTITPVSFDE	CENPE	301	Q02224
PVTLVSRQCTEDIKL	CYP4F22	401	Q6NT55
TTLSEPRQAEIRKEC	CMTR1	521	Q8N1G2
PATKVEITVSCRNLL	CPNE5	21	Q9HCH3
PESFKICTTLREEAL	PTCD2	216	Q8WV60
VTPTLRVEDCSIALL	PTPRM	1196	P28827
SKTELTPEAICRRAA	MUC3B	1056	Q9H195
IIDNSLSLKTPSECV	NPIPA7	256	E9PJI5
IIDNSLSLKTPSECV	NPIPA8	256	P0DM63
IKCITEGLADPEVRT	FAN1	726	Q9Y2M0
TTDVLTIKTDRCPLR	MRPS35	201	P82673
VTTAVPKSERLSCLL	TRMT2B	126	Q96GJ1
TPTKRVCVDTEIKSI	PUS3	466	Q9BZE2
LAPQALEDVKTVVCR	RHOT2	221	Q8IXI1
ATLTLQSECPETKRK	MTF1	121	Q14872
EKLCPEASDIATSVR	RUFY1	181	Q96T51
PLCDVSASEVSKAII	GIN1	176	Q9NXP7
ITPTQVEKFLETCRD	POLR3A	1006	O14802
RAKVLCLSPESSAEA	SLFN11	511	Q7Z7L1
CLIVSVDETIKNPRS	CCT7	511	Q99832
CSDSARILVEVPTKI	SPEGNB	136	A0A087WV53
LPVVTCRTRSVLSEA	PKHD1	86	P08F94
SPTETERCIESLIAV	S100A11	6	P31949
VDRLARKPNSVVISC	DRG2	256	P55039
ITARKSSVLVCLVET	KCTD14	161	Q9BQ13
LTPTEKGRCASLEEI	PLEKHO1	261	Q53GL0
VKDTILCPTIAESRR	RSPO2	181	Q6UXX9
KNCVLLSRPEISTDE	SEC24D	851	O94855
RITAVCKVPDESEVV	TGM3	571	Q08188
EVDTVASECPSLRIK	ACSM2B	166	Q68CK6
ASECPSLRIKLLVSE	ACSM2B	171	Q68CK6
TRELVSCKVPSELIS	ARMCX1	361	Q9P291
SIRCFIKPTETLERS	CLEC16A	361	Q2KHT3
ISCITKFDSKRSPEV	LINC02694	106	Q8NAA6
VSIKQERCDPESVIS	ZBTB25	201	P24278
LTVESSEKESCRTPK	TMEM61	111	Q8N0U2
VTVLKEPLSCARRIS	TRAF3IP3	96	Q9Y228
RSIEEAVPAVCKTRT	PDGFA	86	P04085
ETVRRDSCPAVSKIL	REV3L	2856	O60673
KKSLRSEPSVIIVSC	SPEG	2621	Q15772
SCRLSVVEVAPSKVT	SSH2	686	Q76I76
RVLSETLKSFCLEPE	WDR97	1436	A6NE52
LECAEVKKSSLVPST	SRRM4	366	A7MD48
TLSLRLECSSAIIKP	GAFA1	31	Q96PS6
VTDVVRFIKLTDCAP	SFMBT2	826	Q5VUG0
IKPSECQLEVTTERV	TNR	26	Q92752
RGPSVTEKEVLTCIL	UBR1	1086	Q8IWV7
SLCARPDVRTVELIS	TTC41P	481	Q6P2S7
CVETDIPLKTRKTSE	NFATC3	331	Q12968
TKEICVVRFTPVTEE	PHF3	1266	Q92576
SALLACVREVKVAPS	TLNRD1	226	Q9H1K6
CVREVKVAPSELARS	TLNRD1	231	Q9H1K6
DRVQDKTCPVIISST	THNSL1	651	Q8IYQ7
PALTLDCSTDVLVKR	TTLL2	391	Q9BWV7
SERTCTLAIIKPDAV	NME9	156	Q86XW9
LSDVCDVPTAKIISR	ATIC	321	P31939
SKTVVKEPVDTRVSC	SETD2	771	Q9BYW2
CSKDILNPKDVITTR	ZMYM6	141	O95789
DCAVPISTSLIKQIA	VPS13B	2906	Q7Z7G8
DSKTVGELLVTICSR	TLN2	106	Q9Y4G6
VERPVCKDSTRIRIT	F2	531	P00734
VEISKGETSRECVPI	TTC23	216	Q5W5X9
CTIVEALATIPSRKQ	UBR4	4146	Q5T4S7
VCNESVRTVIVPSEK	ARHGAP21	266	Q5T5U3
IRNCLLSVEPAISTK	TTL	291	Q8NG68
DTASVDLCIKPKTIR	TMLHE	96	Q9NVH6
KAPVRLQECIELFTT	USP11	776	P51784
SPALRCVQTAKLILE	UBASH3A	481	P57075
KRDLNVITSVPSELC	WNK3	1201	Q9BYP7
CQELAVVPDSRSVKV	GOLGA8CP	71	A6NN73
SSLEIVSACRVPSKI	L1TD1	736	Q5T7N2
VSACRVPSKIDEKRL	L1TD1	741	Q5T7N2
CVDSLTSDKASVPIV	MYO9B	1701	Q13459