Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	medium-chain fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	1.27e-06	2	23	2	GO:0140981
GeneOntologyMolecularFunction	16-hydroxypalmitate dehydrogenase activity	CYP4A11 CYP4A22	1.27e-06	2	23	2	GO:0103002
GeneOntologyMolecularFunction	leukotriene-B4 20-monooxygenase activity	CYP4A11 CYP4A22	2.66e-05	7	23	2	GO:0050051
GeneOntologyMolecularFunction	alkane 1-monooxygenase activity	CYP4A11 CYP4A22	2.66e-05	7	23	2	GO:0018685
GeneOntologyMolecularFunction	arachidonate omega-hydroxylase activity	CYP4A11 CYP4A22	5.68e-05	10	23	2	GO:0052869
GeneOntologyMolecularFunction	fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	5.68e-05	10	23	2	GO:0120250
GeneOntologyMolecularFunction	long-chain fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	5.68e-05	10	23	2	GO:0102033
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP4A11 CYP4A22	9.82e-05	13	23	2	GO:0016713
GeneOntologyMolecularFunction	arachidonate binding	CYP4A11 CYP4A22	1.32e-04	15	23	2	GO:0050544
GeneOntologyMolecularFunction	icosanoid binding	CYP4A11 CYP4A22	1.51e-04	16	23	2	GO:0050542
GeneOntologyMolecularFunction	icosatetraenoic acid binding	CYP4A11 CYP4A22	1.51e-04	16	23	2	GO:0050543
GeneOntologyMolecularFunction	transition metal ion binding	CYP4A11 RNF216 APLP2 SHANK3 ZSWIM6 CYP4A22 ERI2	2.75e-04	1189	23	7	GO:0046914
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP4A11 CYP4A22	3.45e-04	24	23	2	GO:0008392
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP4A11 CYP4A22	4.38e-04	27	23	2	GO:0008391
GeneOntologyMolecularFunction	long-chain fatty acid binding	CYP4A11 CYP4A22	4.71e-04	28	23	2	GO:0036041
GeneOntologyMolecularFunction	aromatase activity	CYP4A11 CYP4A22	7.38e-04	35	23	2	GO:0070330
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP4A11 CYP4A22	1.44e-03	49	23	2	GO:0016712
GeneOntologyMolecularFunction	fatty acid binding	CYP4A11 CYP4A22	2.84e-03	69	23	2	GO:0005504
GeneOntologyMolecularFunction	monocarboxylic acid binding	CYP4A11 CYP4A22	6.69e-03	107	23	2	GO:0033293
GeneOntologyMolecularFunction	monooxygenase activity	CYP4A11 CYP4A22	7.69e-03	115	23	2	GO:0004497
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	CYP4A11 CYP4A22	9.30e-03	127	23	2	GO:0016616
GeneOntologyBiologicalProcess	lauric acid metabolic process	CYP4A11 CYP4A22	2.96e-06	3	21	2	GO:0048252
GeneOntologyBiologicalProcess	striatal medium spiny neuron differentiation	SHANK3 ZSWIM6	5.92e-06	4	21	2	GO:0021773
GeneOntologyBiologicalProcess	omega-hydroxylase P450 pathway	CYP4A11 CYP4A22	8.92e-05	14	21	2	GO:0097267
GeneOntologyBiologicalProcess	medium-chain fatty acid metabolic process	CYP4A11 CYP4A22	1.03e-04	15	21	2	GO:0051791
GeneOntologyBiologicalProcess	striatum development	SHANK3 ZSWIM6	2.25e-04	22	21	2	GO:0021756
GeneOntologyBiologicalProcess	linoleic acid metabolic process	CYP4A11 CYP4A22	2.47e-04	23	21	2	GO:0043651
GeneOntologyBiologicalProcess	GABAergic neuron differentiation	SHANK3 ZSWIM6	2.69e-04	24	21	2	GO:0097154
GeneOntologyBiologicalProcess	subpallium development	SHANK3 ZSWIM6	3.67e-04	28	21	2	GO:0021544
GeneOntologyBiologicalProcess	positive regulation of isotype switching	TP53BP1 CD40	4.51e-04	31	21	2	GO:0045830
GeneOntologyBiologicalProcess	glutamate metabolic process	NAGS FPGS	6.79e-04	38	21	2	GO:0006536
MousePheno	increased renal vascular resistance	CYP4A11 CYP4A22	1.39e-05	5	17	2	MP:0005531
MousePheno	abnormal renal sodium reabsorption	CYP4A11 CYP4A22	1.39e-05	5	17	2	MP:0010109
MousePheno	abnormal renal vascular resistance	CYP4A11 CYP4A22	3.88e-05	8	17	2	MP:0005529
MousePheno	abnormal medium spiny neuron morphology	SHANK3 ZSWIM6	3.88e-05	8	17	2	MP:0008462
MousePheno	abnormal renal sodium ion transport	CYP4A11 CYP4A22	3.88e-05	8	17	2	MP:0011442
MousePheno	salt-sensitive hypertension	CYP4A11 CYP4A22	6.23e-05	10	17	2	MP:0004217
MousePheno	abnormal body water content	CYP4A11 CYP4A22	9.12e-05	12	17	2	MP:0000676
MousePheno	abnormal striatum morphology	GPR6 SHANK3 ZSWIM6	9.56e-05	75	17	3	MP:0004077
MousePheno	abnormal vascular resistance	CYP4A11 CYP4A22	2.35e-04	19	17	2	MP:0005532
MousePheno	decreased urine potassium level	CYP4A11 CYP4A22	2.35e-04	19	17	2	MP:0005618
MousePheno	abnormal basal ganglion morphology	GPR6 SHANK3 ZSWIM6	2.67e-04	106	17	3	MP:0006007
MousePheno	abnormal renal transport	CYP4A11 CYP4A22	3.47e-04	23	17	2	MP:0011417
MousePheno	oliguria	CYP4A11 CYP4A22	3.78e-04	24	17	2	MP:0003620
MousePheno	decreased urine output	CYP4A11 CYP4A22	7.19e-04	33	17	2	MP:0031358
MousePheno	abnormal renal reabsorption	CYP4A11 CYP4A22	8.09e-04	35	17	2	MP:0010107
MousePheno	abnormal urine potassium level	CYP4A11 CYP4A22	8.56e-04	36	17	2	MP:0004820
Domain	DUF4195	ZNF280A ZNF280B	8.69e-06	4	23	2	IPR025243
Domain	DUF4195	ZNF280A ZNF280B	8.69e-06	4	23	2	PF13836
Domain	Cyt_P450_E_grp-I	CYP4A11 CYP4A22	1.39e-03	45	23	2	IPR002401
Domain	Cyt_P450_CS	CYP4A11 CYP4A22	1.92e-03	53	23	2	IPR017972
Domain	CYTOCHROME_P450	CYP4A11 CYP4A22	2.22e-03	57	23	2	PS00086
Domain	-	CYP4A11 CYP4A22	2.30e-03	58	23	2	1.10.630.10
Domain	p450	CYP4A11 CYP4A22	2.30e-03	58	23	2	PF00067
Domain	Cyt_P450	CYP4A11 CYP4A22	2.46e-03	60	23	2	IPR001128
Domain	RNaseH-like_dom	FAM200A ERI2	3.24e-03	69	23	2	IPR012337
Pathway	WP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES_PATHWAY	CYP4A11 CYP4A22	3.79e-05	9	15	2	M39819
Pathway	REACTOME_SYNTHESIS_OF_16_20_HYDROXYEICOSATETRAENOIC_ACIDS_HETE	CYP4A11 CYP4A22	5.78e-05	11	15	2	MM14863
Pathway	REACTOME_EICOSANOIDS	CYP4A11 CYP4A22	6.93e-05	12	15	2	MM14845
Pathway	REACTOME_EICOSANOIDS	CYP4A11 CYP4A22	6.93e-05	12	15	2	M27129
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP4A11 CYP4A22	6.93e-05	12	15	2	M27128
Pathway	WP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES	CYP4A11 CYP4A22	9.55e-05	14	15	2	MM15842
Pathway	REACTOME_FATTY_ACIDS	CYP4A11 CYP4A22	1.10e-04	15	15	2	M27126
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP4A11 CYP4A22	1.60e-04	18	15	2	MM14843
Pathway	REACTOME_FATTY_ACIDS	CYP4A11 CYP4A22	1.60e-04	18	15	2	MM14841
Pathway	REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX	CYP4A11 CYP4A22	2.19e-04	21	15	2	M27137
Pathway	REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX	CYP4A11 CYP4A22	3.13e-04	25	15	2	MM14858
Pathway	WP_EICOSANOID_METABOLISM_VIA_LIPOOXYGENASES_LOX	CYP4A11 CYP4A22	4.22e-04	29	15	2	M39858
Pathway	WP_EICOSANOID_METABOLISM_VIA_CYCLOOXYGENASES_COX	CYP4A11 CYP4A22	4.83e-04	31	15	2	M39851
Pathway	BIOCARTA_NUCLEARRS_PATHWAY	CYP4A11 CYP4A22	5.47e-04	33	15	2	MM1448
Pathway	WP_EICOSANOID_METABOLISM_VIA_LIPOXYGENASES_LOX	CYP4A11 CYP4A22	5.47e-04	33	15	2	MM15963
Pathway	WP_EICOSANOID_METABOLISM_VIA_CYCLOOXYGENASES_COX	CYP4A11 CYP4A22	5.47e-04	33	15	2	MM15918
Pathway	BIOCARTA_NUCLEARRS_PATHWAY	CYP4A11 CYP4A22	5.81e-04	34	15	2	M16393
Pathway	KEGG_FATTY_ACID_METABOLISM	CYP4A11 CYP4A22	8.88e-04	42	15	2	M699
Pathway	KEGG_ARACHIDONIC_ACID_METABOLISM	CYP4A11 CYP4A22	1.69e-03	58	15	2	M5410
Pathway	REACTOME_ARACHIDONIC_ACID_METABOLISM	CYP4A11 CYP4A22	1.75e-03	59	15	2	M27140
Pathway	REACTOME_ARACHIDONIC_ACID_METABOLISM	CYP4A11 CYP4A22	1.87e-03	61	15	2	MM14861
Pathway	WP_OXIDATION_BY_CYTOCHROME_P450	CYP4A11 CYP4A22	1.93e-03	62	15	2	M39653
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP4A11 CYP4A22	2.05e-03	64	15	2	M5650
Pathway	KEGG_RETINOL_METABOLISM	CYP4A11 CYP4A22	2.05e-03	64	15	2	M9488
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP4A11 CYP4A22	2.18e-03	66	15	2	MM14839
Pathway	KEGG_PPAR_SIGNALING_PATHWAY	CYP4A11 CYP4A22	2.38e-03	69	15	2	M13088
Pathway	WP_PPAR_SIGNALING_PATHWAY	CYP4A11 CYP4A22	2.66e-03	73	15	2	MM15995
Pubmed	The rat clofibrate-inducible CYP4A subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes.	CYP4A11 CYP4A22	4.18e-07	2	23	2	2766933
Pubmed	Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice.	CYP4A11 CYP4A22	4.18e-07	2	23	2	29277328
Pubmed	Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.	CYP4A11 CYP4A22	4.18e-07	2	23	2	15611369
Pubmed	Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation.	CYP4A11 CYP4A22	4.18e-07	2	23	2	17112342
Pubmed	Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population.	CYP4A11 CYP4A22	4.18e-07	2	23	2	21820496
Pubmed	Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension.	CYP4A11 CYP4A22	4.18e-07	2	23	2	11320253
Pubmed	Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.	CYP4A11 CYP4A22	4.18e-07	2	23	2	23641057
Pubmed	20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension.	CYP4A11 CYP4A22	4.18e-07	2	23	2	23825080
Pubmed	Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.	CYP4A11 CYP4A22	4.18e-07	2	23	2	16691295
Pubmed	Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: developmental and hormonal regulation in liver and kidney.	CYP4A11 CYP4A22	4.18e-07	2	23	2	8031839
Pubmed	Characterization of the CYP4A11 gene, a second CYP4A gene in humans.	CYP4A11 CYP4A22	4.18e-07	2	23	2	12464262
Pubmed	The P450 gene superfamily: recommended nomenclature.	CYP4A11 CYP4A22	4.18e-07	2	23	2	3829886
Pubmed	Renal function and vasomotor activity in mice lacking the Cyp4a14 gene.	CYP4A11 CYP4A22	4.18e-07	2	23	2	20943934
Pubmed	Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein.	CYP4A11 CYP4A22	4.18e-07	2	23	2	10860550
Pubmed	The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis.	CYP4A11 CYP4A22	4.18e-07	2	23	2	28912346
Pubmed	High-fat diet-induced obesity and insulin resistance in CYP4a14-/- mice is mediated by 20-HETE.	CYP4A11 CYP4A22	4.18e-07	2	23	2	30088983
Pubmed	Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta.	CYP4A11 CYP4A22	4.18e-07	2	23	2	15066132
Pubmed	Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes.	CYP4A11 CYP4A22	4.18e-07	2	23	2	24413902
Pubmed	Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.	CYP4A11 CYP4A22	4.18e-07	2	23	2	19208908
Pubmed	Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice.	CYP4A11 CYP4A22	1.25e-06	3	23	2	19713718
Pubmed	Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization.	CYP4A11 CYP4A22	1.25e-06	3	23	2	8011168
Pubmed	Peroxisome proliferator activated receptor alpha regulates a male-specific cytochrome P450 in mouse liver.	CYP4A11 CYP4A22	1.25e-06	3	23	2	15313227
Pubmed	Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis.	CYP4A11 CYP4A22	1.25e-06	3	23	2	28270609
Pubmed	The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature.	CYP4A11 CYP4A22	1.25e-06	3	23	2	1991046
Pubmed	Genetic analysis of resistance to radiation lymphomagenesis with recombinant inbred strains of mice.	CYP4A11 CYP4A22	1.25e-06	3	23	2	2354437
Pubmed	H19/Mir-130b-3p/Cyp4a14 potentiate the effect of praziquantel on liver in the treatment of Schistosoma japonicum infection.	CYP4A11 CYP4A22	1.25e-06	3	23	2	37659685
Pubmed	A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans.	CYP4A11 CYP4A22	1.25e-06	3	23	2	9271096
Pubmed	Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens.	CYP4A11 APLP2 CYP4A22	1.78e-06	36	23	3	9344654
Pubmed	Mapping of the azh locus to mouse chromosome 4.	CYP4A11 CYP4A22	2.51e-06	4	23	2	1552159
Pubmed	Differences in metabolite burden of di(2-ethylhexyl)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice.	CYP4A11 CYP4A22	2.51e-06	4	23	2	22159897
Pubmed	Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats.	CYP4A11 CYP4A22	2.51e-06	4	23	2	10049703
Pubmed	Salt modulates vascular response through adenosine A(2A) receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase.	CYP4A11 CYP4A22	2.51e-06	4	23	2	21161333
Pubmed	Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal.	CYP4A11 CYP4A22	2.51e-06	4	23	2	8334987
Pubmed	Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase.	CYP4A11 CYP4A22	4.18e-06	5	23	2	20427718
Pubmed	Mapping of guanylin to murine chromosome 4 and human chromosome 1p34-p35.	CYP4A11 CYP4A22	4.18e-06	5	23	2	7601480
Pubmed	Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs.	CYP4A11 CYP4A22	4.18e-06	5	23	2	8363569
Pubmed	Genesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cells.	CYP4A11 CYP4A22	6.26e-06	6	23	2	8798505
Pubmed	Organization of the distal end of mouse chromosome 4.	CYP4A11 CYP4A22	6.26e-06	6	23	2	3166417
Pubmed	Peroxisome proliferator-activated receptor-α accelerates α-chlorofatty acid catabolism.	CYP4A11 CYP4A22	6.26e-06	6	23	2	28007964
Pubmed	Peroxisome proliferator-activated receptor alpha-responsive genes induced in the newborn but not prenatal liver of peroxisomal fatty acyl-CoA oxidase null mice.	CYP4A11 CYP4A22	6.26e-06	6	23	2	11461119
Pubmed	Mouse uroporphyrinogen decarboxylase: cDNA cloning, expression, and mapping.	CYP4A11 CYP4A22	6.26e-06	6	23	2	8661721
Pubmed	Molecular mapping of the mouse db mutation.	CYP4A11 CYP4A22	8.77e-06	7	23	2	1978328
Pubmed	Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity.	CYP4A11 CYP4A22	8.77e-06	7	23	2	12958197
Pubmed	Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors.	CYP4A11 CYP4A22	8.77e-06	7	23	2	18648086
Pubmed	Microdissection and microcloning of mid-chromosome 4: genetic mapping of 41 microdissection clones.	CYP4A11 CYP4A22	1.17e-05	8	23	2	8098006
Pubmed	Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis.	CYP4A11 CYP4A22	1.17e-05	8	23	2	18488193
Pubmed	Mapping genes encoding drug-metabolizing enzymes in recombinant inbred mice.	CYP4A11 CYP4A22	1.50e-05	9	23	2	1685137
Pubmed	The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature.	CYP4A11 CYP4A22	1.50e-05	9	23	2	7678494
Pubmed	Genetic mapping of meander tail, a mouse mutation affecting cerebellar development.	CYP4A11 CYP4A22	1.88e-05	10	23	2	2037292
Pubmed	IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice.	TP53BP1 CD40	3.25e-05	13	23	2	28137874
Pubmed	Slc25a17 Gene Trapped Mice: PMP34 Plays a Role in the Peroxisomal Degradation of Phytanic and Pristanic Acid.	CYP4A11 CYP4A22	3.25e-05	13	23	2	32266253
Pubmed	Ionizing radiation-induced gene modulations, cytokine content changes and telomere shortening in mouse fetuses exhibiting forelimb defects.	TP53BP1 CD40	3.25e-05	13	23	2	18722365
Pubmed	Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism.	CYP4A11 CYP4A22	4.37e-05	15	23	2	29968852
Pubmed	Exon structure of the nuclear factor I DNA-binding domain from C. elegans to mammals.	CYP4A11 CYP4A22	4.99e-05	16	23	2	10087299
Pubmed	Effects of perfluorooctanoic acid (PFOA) on expression of peroxisome proliferator-activated receptors (PPAR) and nuclear receptor-regulated genes in fetal and postnatal CD-1 mouse tissues.	CYP4A11 CYP4A22	4.99e-05	16	23	2	22154759
Pubmed	Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.	CYP4A11 CYP4A22	5.66e-05	17	23	2	27197076
Pubmed	Expression of murine cyclin B1 mRNAs and genetic mapping of related genomic sequences.	CYP4A11 CYP4A22	6.36e-05	18	23	2	1387105
Pubmed	Loss of the neurodevelopmental gene Zswim6 alters striatal morphology and motor regulation.	GPR6 ZSWIM6	7.10e-05	19	23	2	28433741
Pubmed	Intracisternal A-type particle elements as genetic markers: detection by repeat element viral element amplified locus-PCR.	CYP4A11 CYP4A22	1.14e-04	24	23	2	7873878
Pubmed	Molecular genetic linkage maps of mouse chromosomes 4 and 6.	CYP4A11 CYP4A22	1.35e-04	26	23	2	1684952
Pubmed	Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.	CYP4A11 CYP4A22	1.45e-04	27	23	2	28167773
Pubmed	The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice.	CYP4A11 CYP4A22	1.68e-04	29	23	2	28364022
Pubmed	Genetic mapping of six mouse peroxiredoxin genes and fourteen peroxiredoxin related sequences.	CYP4A11 CYP4A22	2.90e-04	38	23	2	10501973
Pubmed	Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.	CYP4A11 CYP4A22	3.89e-04	44	23	2	12745259
Pubmed	Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions.	CYP4A11 CYP4A22	5.65e-04	53	23	2	15306695
Pubmed	Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation.	SHANK3 SFI1	6.08e-04	55	23	2	24200680
Interaction	CYP4A22 interactions	CYP4A11 CYP4A22	3.74e-06	3	23	2	int:CYP4A22
Interaction	CYP4A11 interactions	CYP4A11 CYP4A22	1.24e-05	5	23	2	int:CYP4A11
Interaction	ZNF280B interactions	ZNF280A ZNF280B	1.86e-05	6	23	2	int:ZNF280B
Cytoband	22q11.22	ZNF280A ZNF280B	6.04e-05	23	23	2	22q11.22
Cytoband	1p33	CYP4A11 CYP4A22	1.41e-04	35	23	2	1p33
Cytoband	Ensembl 112 genes in cytogenetic band chr1p33	CYP4A11 CYP4A22	4.32e-04	61	23	2	chr1p33
GeneFamily	Cytochrome P450 family 4	CYP4A11 CYP4A22	2.97e-04	36	13	2	1003
Coexpression	FUJIWARA_PARK2_HEPATOCYTE_PROLIFERATION_DN	CYP4A11 CYP4A22	3.30e-05	10	23	2	MM560
Coexpression	WIEMANN_TELOMERE_SHORTENING_AND_CHRONIC_LIVER_DAMAGE_UP	CYP4A11 CYP4A22	5.71e-05	13	23	2	MM530
Coexpression	FUJIWARA_PARK2_HEPATOCYTE_PROLIFERATION_UP	CYP4A11 CYP4A22	8.77e-05	16	23	2	MM559
Disease	X-14939 measurement	CYP4A11 CYP4A22	8.70e-06	6	23	2	EFO_0800747
Disease	autosomal recessive polycystic kidney disease (biomarker_via_orthology)	CYP4A11 CYP4A22	3.18e-05	11	23	2	DOID:0110861 (biomarker_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	ZNF280A SHANK3 ZNF280B	2.20e-04	152	23	3	DOID:0060041 (implicated_via_orthology)
Disease	triglycerides to total lipids in very large HDL percentage	TP53BP1 CD40	1.07e-03	62	23	2	EFO_0022339
Disease	intellectual disability (implicated_via_orthology)	ZNF280A ZNF280B	1.56e-03	75	23	2	DOID:1059 (implicated_via_orthology)
Disease	cholesterol in large HDL measurement	TP53BP1 CD40	1.77e-03	80	23	2	EFO_0021900
Disease	Hodgkins lymphoma	CPLANE1 ERI2	1.86e-03	82	23	2	EFO_0000183
Disease	rheumatoid arthritis	TMEM151B ALPK1 CD40	5.35e-03	462	23	3	EFO_0000685

Protein segments in the cluster

Peptide	Gene	Start	Entry
RNDSWEDHTTCQHCH	ZNF280A	326	P59817
NDSWENHTTCQHCHR	ZNF280B	336	Q86YH2
CWNDGKHHHSQEIIE	ERI2	46	A8K979
WTHRACQLAHQHTDQ	CYP4A11	251	Q02928
ATHNNAVWNHCFIHR	FAM200A	231	Q8TCP9
QRNAFWVHHLHQEEI	ALPK1	1046	Q96QP1
RMEVCENHQHWHTVV	APLP2	156	Q06481
ENHQHWHTVVKEACL	APLP2	161	Q06481
PNTHCVWHIQVATDH	MFRP	166	Q9BY79
VVWRHAHQIALQQHC	GPR6	251	P46095
HLQAELHQHGCWTVT	ISM2	151	Q6H9L7
RHWLTQFQTCHHSAD	NAGS	121	Q8N159
HVHWAQQDCHLCSLI	CPLANE1	231	Q9H799
WTHRACQLAHQHTDQ	CYP4A22	251	Q5TCH4
RCLEHQQHWNHLDEE	FPGS	466	Q05932
NESEHHWDMVRCHLQ	HERVK_113	566	Q902F9
RHQEQEWQTVACAHH	SFI1	566	A8K8P3
CWHCQARHELQHRVD	TMEM151B	131	Q8IW70
IHLNNFHCHRGQEWI	RNF216	11	Q9NWF9
WQEIHQACRFGHVQH	SHANK3	251	Q9BYB0
VSHVWVHDSCHANQL	TP53BP1	1826	Q12888
RTHHDNWQEHKQQFT	PSME4	1811	Q14997
CWENNHLVMHQRGHS	ZNF786	196	Q8N393
ACDLHWQDSHLQHII	ZSWIM6	521	Q9HCJ5
EFLDTWNRETHCHQH	CD40	66	P25942