Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein serine kinase activity	ATR LRRK2 CDKL1 PRKCA PRKCD PKN2 PLK1 TSSK4 WNK3 MAP3K19	4.44e-05	363	114	10	GO:0106310
GeneOntologyMolecularFunction	diacylglycerol-dependent serine/threonine kinase activity	PRKCA PRKCD PKN2	9.61e-05	16	114	3	GO:0004697
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	HK2 ATR LRRK2 CDKL1 RYK PIK3C2G PRKCA PRKCD PKN2 PLK1 TSSK4 WNK3 MAP3K19	2.05e-04	709	114	13	GO:0016773
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	ATR LRRK2 CDKL1 PRKCA PRKCD PKN2 PLK1 TSSK4 WNK3 MAP3K19	2.40e-04	446	114	10	GO:0004674
GeneOntologyMolecularFunction	kinase activity	HK2 ATR LRRK2 CDKL1 RYK PIK3C2G PRKCA PRKCD PKN2 PLK1 TSSK4 WNK3 MAP3K19	4.20e-04	764	114	13	GO:0016301
GeneOntologyBiologicalProcess	peptidyl-threonine phosphorylation	LRRK2 PRKCA PRKCD PLK1 TSSK4 WNK3	4.52e-05	115	115	6	GO:0018107
GeneOntologyBiologicalProcess	nuclear membrane disassembly	ATR PRKCA PLK1	4.64e-05	13	115	3	GO:0051081
GeneOntologyBiologicalProcess	membrane disassembly	ATR PRKCA PLK1	5.88e-05	14	115	3	GO:0030397
GeneOntologyBiologicalProcess	peptidyl-threonine modification	LRRK2 PRKCA PRKCD PLK1 TSSK4 WNK3	7.21e-05	125	115	6	GO:0018210
Domain	C2	SYTL2 FER1L6 SYNGAP1 PIK3C2G PRKCA PRKCD PKN2 DOC2B	1.83e-06	137	113	8	SM00239
Domain	C2	SYTL2 FER1L6 SYNGAP1 PIK3C2G PRKCA PRKCD PKN2 DOC2B	2.39e-06	142	113	8	PS50004
Domain	-	SYTL2 FER1L6 SYNGAP1 PIK3C2G PRKCA PRKCD PKN2 DOC2B	3.26e-06	148	113	8	2.60.40.150
Domain	C2_dom	SYTL2 FER1L6 SYNGAP1 PIK3C2G PRKCA PRKCD PKN2 DOC2B	6.98e-06	164	113	8	IPR000008
Domain	VIT	ITIH1 PARP4 ITIH6	1.18e-05	8	113	3	PF08487
Domain	VIT	ITIH1 PARP4 ITIH6	1.18e-05	8	113	3	SM00609
Domain	VIT	ITIH1 PARP4 ITIH6	2.51e-05	10	113	3	PS51468
Domain	VIT	ITIH1 PARP4 ITIH6	2.51e-05	10	113	3	IPR013694
Domain	Kinase-like_dom	ATR LRRK2 CDKL1 RYK PIK3C2G PRKCA PRKCD PKN2 PLK1 TSSK4 WNK3 MAP3K19	1.09e-04	542	113	12	IPR011009
Domain	C2	SYTL2 FER1L6 SYNGAP1 PIK3C2G PRKCA DOC2B	1.45e-04	131	113	6	PF00168
Domain	PX	PIK3C2G SNX32 NISCH ARHGAP33	2.36e-04	50	113	4	PS50195
Domain	-	PIK3C2G SNX32 NISCH ARHGAP33	2.55e-04	51	113	4	3.30.1520.10
Domain	Phox	PIK3C2G SNX32 NISCH ARHGAP33	2.75e-04	52	113	4	IPR001683
Domain	Ser/Thr_kinase_AS	LRRK2 CDKL1 PRKCA PRKCD PKN2 PLK1 TSSK4 WNK3 MAP3K19	3.21e-04	357	113	9	IPR008271
Domain	S_TKc	LRRK2 CDKL1 PRKCA PRKCD PKN2 PLK1 TSSK4 WNK3 MAP3K19	3.34e-04	359	113	9	SM00220
Domain	PROTEIN_KINASE_ST	LRRK2 CDKL1 PRKCA PRKCD PKN2 PLK1 TSSK4 WNK3 MAP3K19	3.55e-04	362	113	9	PS00108
Domain	VWA	CACNA2D2 ITIH1 PARP4 ITIH6	3.66e-04	56	113	4	PF00092
Domain	PROTEIN_KINASE_ATP	LRRK2 CDKL1 RYK PRKCA PRKCD PKN2 PLK1 TSSK4 WNK3 MAP3K19	4.74e-04	459	113	10	PS00107
Domain	Pkinase	LRRK2 CDKL1 PRKCA PRKCD PKN2 PLK1 TSSK4 WNK3 MAP3K19	5.14e-04	381	113	9	PF00069
Domain	ITI_HC_C	ITIH1 ITIH6	5.36e-04	6	113	2	IPR010600
Domain	ITI_HC_C	ITIH1 ITIH6	5.36e-04	6	113	2	PF06668
Domain	Prot_kinase_dom	LRRK2 CDKL1 RYK PRKCA PRKCD PKN2 PLK1 TSSK4 WNK3 MAP3K19	7.72e-04	489	113	10	IPR000719
Domain	PROTEIN_KINASE_DOM	LRRK2 CDKL1 RYK PRKCA PRKCD PKN2 PLK1 TSSK4 WNK3 MAP3K19	8.21e-04	493	113	10	PS50011
Domain	-	CACNA2D2 ITIH1 PARP4 ITIH6	1.06e-03	74	113	4	3.40.50.410
Domain	ARM-type_fold	RALGAPA1 ATR IFT172 LRRK2 FRYL DOCK5 PIK3C2G UTP20	1.06e-03	339	113	8	IPR016024
Domain	Pkinase_C	PRKCA PRKCD PKN2	1.44e-03	37	113	3	IPR017892
Domain	VWFA	CACNA2D2 ITIH1 PARP4 ITIH6	1.55e-03	82	113	4	PS50234
Domain	VWA	CACNA2D2 ITIH1 PARP4 ITIH6	1.69e-03	84	113	4	SM00327
Domain	GPCR_2_extracellular_dom	ADGRV1 CALCRL ADGRF1	1.81e-03	40	113	3	IPR001879
Domain	G_PROTEIN_RECEP_F2_1	ADGRV1 CALCRL ADGRF1	1.81e-03	40	113	3	PS00649
Domain	G_PROTEIN_RECEP_F2_3	ADGRV1 CALCRL ADGRF1	1.81e-03	40	113	3	PS50227
Domain	DHR-1_domain	DOCK5 DOCK7	1.93e-03	11	113	2	IPR027007
Domain	DHR_2	DOCK5 DOCK7	1.93e-03	11	113	2	PS51651
Domain	DHR_1	DOCK5 DOCK7	1.93e-03	11	113	2	PS51650
Domain	DHR-2	DOCK5 DOCK7	1.93e-03	11	113	2	PF06920
Domain	DOCK	DOCK5 DOCK7	1.93e-03	11	113	2	IPR026791
Domain	DOCK_C	DOCK5 DOCK7	1.93e-03	11	113	2	IPR010703
Domain	DOCK-C2	DOCK5 DOCK7	1.93e-03	11	113	2	PF14429
Domain	DHR-2	DOCK5 DOCK7	1.93e-03	11	113	2	IPR027357
Domain	Pkinase_C	PRKCA PRKCD PKN2	2.08e-03	42	113	3	PF00433
Domain	Protein_kinase_ATP_BS	LRRK2 CDKL1 PRKCA PRKCD PKN2 PLK1 TSSK4 MAP3K19	2.15e-03	379	113	8	IPR017441
Domain	VWF_A	CACNA2D2 ITIH1 PARP4 ITIH6	3.08e-03	99	113	4	IPR002035
Domain	PX	PIK3C2G SNX32 NISCH	3.24e-03	49	113	3	PF00787
Domain	7tm_2	ADGRV1 CALCRL ADGRF1	3.44e-03	50	113	3	PF00002
Domain	G_PROTEIN_RECEP_F2_2	ADGRV1 CALCRL ADGRF1	3.44e-03	50	113	3	PS00650
Domain	PI3/4_kinase_CS	ATR PIK3C2G	3.62e-03	15	113	2	IPR018936
Domain	-	ATR PIK3C2G	4.12e-03	16	113	2	1.10.1070.11
Domain	PI3Kc	ATR PIK3C2G	4.12e-03	16	113	2	SM00146
Domain	AGC-kinase_C	PRKCA PRKCD PKN2	4.74e-03	56	113	3	IPR000961
Domain	AGC_KINASE_CTER	PRKCA PRKCD PKN2	4.74e-03	56	113	3	PS51285
Domain	S_TK_X	PRKCA PRKCD PKN2	4.74e-03	56	113	3	SM00133
Domain	PI3_PI4_kinase	ATR PIK3C2G	5.21e-03	18	113	2	PF00454
Domain	PI3_4_KINASE_1	ATR PIK3C2G	5.21e-03	18	113	2	PS00915
Domain	PI3_4_KINASE_2	ATR PIK3C2G	5.21e-03	18	113	2	PS00916
Domain	PI3/4_kinase_cat_dom	ATR PIK3C2G	5.21e-03	18	113	2	IPR000403
Domain	PI3_4_KINASE_3	ATR PIK3C2G	5.21e-03	18	113	2	PS50290
Domain	GPCR_2_secretin-like	ADGRV1 CALCRL ADGRF1	5.74e-03	60	113	3	IPR000832
Domain	GPCR_2-like	ADGRV1 CALCRL ADGRF1	5.74e-03	60	113	3	IPR017981
Domain	G_PROTEIN_RECEP_F2_4	ADGRV1 CALCRL ADGRF1	6.02e-03	61	113	3	PS50261
Pathway	REACTOME_RAC1_GTPASE_CYCLE	ARHGAP26 ERBIN DOCK5 NISCH DOCK7 PKN2 ARHGAP33	5.07e-05	175	78	7	MM15599
Pathway	REACTOME_RAC1_GTPASE_CYCLE	ARHGAP26 ERBIN DOCK5 NISCH DOCK7 PKN2 ARHGAP33	6.96e-05	184	78	7	M41809
Pathway	WP_TRYPTOPHAN_METABOLISM	UBE3A ALDH3A2 KYNU TPH1	1.40e-04	48	78	4	MM15902
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	RALGAPA1 ARHGAP26 ERBIN DOCK5 NISCH DOCK7 PRKCA PRKCD PKN2 ALDH3A2 PLK1 DYNC1H1 ARHGAP33	1.47e-04	720	78	13	M41838
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	RALGAPA1 ARHGAP26 ERBIN DOCK5 NISCH DOCK7 PRKCD PKN2 ALDH3A2 PLK1 DYNC1H1 ARHGAP33	2.19e-04	649	78	12	MM15690
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	DMXL2 HK2 GIPC3 PTP4A2 UBA1 MTMR4 LLGL2 TRPM3 KCNH1 PRSS21 PRKCA PRKCD PLK1 ATP4A WNK3	2.27e-08	730	116	15	34857952
Pubmed	FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice.	GARIN1A RAB2B RAB2A	1.44e-07	4	116	3	34714330
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	TOPAZ1 NEXMIF SLC26A9 ZZEF1 TRIM43B DOCK5 PARP4 TRPM3 EXOC3L4 UTP20 CHD6 CNOT1 BANK1 DYNC1H1	1.77e-07	736	116	14	29676528
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RALGAPA1 AGO2 ARHGAP26 VPS50 ADGRV1 ZZEF1 CEMIP2 LRIG3 RBM12 HERC4 CNOT1 ZNF687	2.22e-07	529	116	12	14621295
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DMXL2 HK2 ATR TUBGCP4 ZZEF1 CEMIP2 DOCK5 PARP4 LLGL2 NISCH PRSS21 DOCK7 KYNU	2.85e-07	650	116	13	38777146
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DMXL2 AGO2 ERBIN ITIH1 SYNGAP1 UBA1 UBE3A NISCH DOCK7 PRKCA RAB2A CNOT1 DYNC1H1 WNK3	4.19e-06	963	116	14	28671696
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	ATR FRYL DOCK5 PARP4 DOCK7 UTP20 CNOT1	5.49e-06	202	116	7	33005030
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RALGAPA1 KBTBD3 TMEM144 AGO2 CACNA2D2 FRMPD1 FRYL WDR25 ADGRV1 CPT1A ZNF236 ERBIN DOCK5 ABCG1 CHD6 NQO2 CNOT1	9.21e-06	1489	116	17	28611215
Pubmed	Molecular cloning and characterization of a novel human Rab ( Rab2B) gene.	RAB2B RAB2A	1.10e-05	2	116	2	12376746
Pubmed	Role of oncogenes and tumor suppressor genes in multistage carcinogenesis.	PRKCA PRKCD	1.10e-05	2	116	2	7963691
Pubmed	Protein kinase C regulates vascular calcification via cytoskeleton reorganization and osteogenic signaling.	PRKCA PRKCD	1.10e-05	2	116	2	25445591
Pubmed	Inhibition of ZL55 cell proliferation by ADP via PKC-dependent signalling pathway.	PRKCA PRKCD	1.10e-05	2	116	2	28777435
Pubmed	PKCα and PKCδ activation regulates transcriptional activity and degradation of progesterone receptor in human astrocytoma cells.	PRKCA PRKCD	1.10e-05	2	116	2	25514083
Pubmed	Calcium-dependent involucrin expression is inversely regulated by protein kinase C (PKC)alpha and PKCdelta.	PRKCA PRKCD	1.10e-05	2	116	2	11864971
Pubmed	Differential expression of protein kinase C alpha and delta in testes of mouse at various stages of development.	PRKCA PRKCD	1.10e-05	2	116	2	15540248
Pubmed	ATR enforces the topoisomerase II-dependent G2 checkpoint through inhibition of Plk1 kinase.	ATR PLK1	1.10e-05	2	116	2	12147700
Pubmed	Protein kinase Cδ but not PKCα is involved in insulin-induced glucose metabolism in hepatocytes.	PRKCA PRKCD	1.10e-05	2	116	2	22271577
Pubmed	Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy.	RAB2B RAB2A	1.10e-05	2	116	2	28063257
Pubmed	PKC-δ/PKC-α activity balance regulates the lethal effects of cisplatin.	PRKCA PRKCD	1.10e-05	2	116	2	26300055
Pubmed	High glucose increases nitric oxide generation in lipopolysaccharide-activated macrophages by enhancing activity of protein kinase C-α/δ and NF-κB.	PRKCA PRKCD	1.10e-05	2	116	2	22706318
Pubmed	Kinase activity of casein kinase 1 delta (CK1δ) is modulated by protein kinase C α (PKCα) by site-specific phosphorylation within the kinase domain of CK1δ.	PRKCA PRKCD	1.10e-05	2	116	2	31096047
Pubmed	Direct binding and activation of protein kinase C isoforms by aldosterone and 17beta-estradiol.	PRKCA PRKCD	1.10e-05	2	116	2	17666590
Pubmed	LRRK2 Regulates CPT1A to Promote β-Oxidation in HepG2 Cells.	LRRK2 CPT1A	1.10e-05	2	116	2	32916992
Pubmed	Rapid production of platelet-activating factor is induced by protein kinase Cα-mediated phosphorylation of lysophosphatidylcholine acyltransferase 2 protein.	LPCAT2 PRKCA	1.10e-05	2	116	2	24742674
Pubmed	Differential and conditional activation of PKC-isoforms dictates cardiac adaptation during physiological to pathological hypertrophy.	PRKCA PRKCD	1.10e-05	2	116	2	25116170
Pubmed	Overexpressed PKCδ downregulates the expression of PKCα in B16F10 melanoma: induction of apoptosis by PKCδ via ceramide generation.	PRKCA PRKCD	1.10e-05	2	116	2	24632809
Pubmed	SETD2-mediated H3K14 trimethylation promotes ATR activation and stalled replication fork restart in response to DNA replication stress.	ATR SETD2	1.10e-05	2	116	2	34074749
Pubmed	Attenuation of PKCδ enhances metabolic activity and promotes expansion of blood progenitors.	PRKCA PRKCD	1.10e-05	2	116	2	30446598
Pubmed	FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice.	RAG1 FLT3LG	1.10e-05	2	116	2	38701783
Pubmed	Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.	DMXL2 LRRK2 LRIG3 MTMR4 CNOT1 ATP4A	1.13e-05	149	116	6	22664934
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	CACNA2D2 SYTL2 FRMPD1 TUBGCP4 UBA1 PLK1 NQO2 CNOT1	1.61e-05	331	116	8	19490893
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	DMXL2 ERBIN SYNGAP1 UBA1 PRKCA RAB2A DYNC1H1	2.24e-05	251	116	7	27507650
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SYTL2 TRPM3 RAVER2 HERC4 WNK3	2.32e-05	101	116	5	10997877
Pubmed	Does 3D Phenotyping Yield Substantial Insights in the Genetics of the Mouse Mandible Shape?	ATR IFT172 RYK	2.84e-05	18	116	3	26921296
Pubmed	Attenuation of mouse mesangial cell contractility by high glucose and mannitol: involvement of protein kinase C and focal adhesion kinase.	PRKCA PRKCD	3.30e-05	3	116	2	14966364
Pubmed	Regulation of peroxisome proliferator-activated receptor alpha by protein kinase C.	PRKCA PRKCD	3.30e-05	3	116	2	16042408
Pubmed	Separation of plasmacytoid dendritic cells from B-cell-biased lymphoid progenitor (BLP) and Pre-pro B cells using PDCA-1.	RAG1 FLT3LG	3.30e-05	3	116	2	24205225
Pubmed	Dose-dependent differential expression of protein kinase C isozymes in mouse lymphocytes after gamma irradiation in vivo and ex vivo.	PRKCA PRKCD	3.30e-05	3	116	2	12643789
Pubmed	The Heteromeric Complex Formed by Dopamine Receptor D5 and CCR9 Leads the Gut Homing of CD4+ T Cells Upon Inflammation.	RAG1 CCR9	3.30e-05	3	116	2	33864900
Pubmed	Protein Kinase C Modulation Determines the Mesoderm/Extraembryonic Fate Under BMP4 Induction From Human Pluripotent Stem Cells.	PRKCA PRKCD	3.30e-05	3	116	2	36648303
Pubmed	Role of FGFR2b expression and signaling in keratinocyte differentiation: sequential involvement of PKCδ and PKCα.	PRKCA PRKCD	3.30e-05	3	116	2	29752438
Pubmed	Flt3 signaling regulates the proliferation, survival, and maintenance of multipotent hematopoietic progenitors that generate B cell precursors.	RAG1 FLT3LG	3.30e-05	3	116	2	24444745
Pubmed	Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance.	RAG1 CCR9	3.30e-05	3	116	2	22444632
Pubmed	The interplay between intracellular progesterone receptor and PKC plays a key role in migration and invasion of human glioblastoma cells.	PRKCA PRKCD	3.30e-05	3	116	2	27717886
Pubmed	Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine.	RAG1 CCR9	3.30e-05	3	116	2	20400707
Pubmed	The interplay between estrogen receptor beta and protein kinase C, a crucial collaboration for medulloblastoma cell proliferation and invasion.	PRKCA PRKCD	3.30e-05	3	116	2	35033667
Pubmed	Protein Kinase C Isoforms Differentially Regulate Hypoxia-Inducible Factor-1α Accumulation in Cancer Cells.	PRKCA PRKCD	3.30e-05	3	116	2	26284819
Pubmed	Protein kinase C (PKC) delta regulates PKCalpha activity in a Syndecan-4-dependent manner.	PRKCA PRKCD	3.30e-05	3	116	2	11916978
Pubmed	Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells.	RAG1 HK2	3.30e-05	3	116	2	37497007
Pubmed	CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epithelium.	RAG1 CCR9	3.30e-05	3	116	2	16582913
Pubmed	RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells.	ATR PLK1	3.30e-05	3	116	2	24142876
Pubmed	Nanog expression is negatively regulated by protein kinase C activities in human cancer cell lines.	PRKCA PRKCD	3.30e-05	3	116	2	23536578
Pubmed	Protein kinase C isoforms α, δ and ε are differentially expressed in mouse ovaries at different stages of postnatal development.	PRKCA PRKCD	3.30e-05	3	116	2	25491605
Pubmed	Mild replication stress causes premature centriole disengagement via a sub-critical Plk1 activity under the control of ATR-Chk1.	ATR PLK1	3.30e-05	3	116	2	37773176
Pubmed	A kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells.	PRKCA PRKCD	3.30e-05	3	116	2	25225290
Pubmed	PKC mediates fluctuant ERK-paxillin signaling for hepatocyte growth factor-induced migration of hepatoma cell HepG2.	PRKCA PRKCD	3.30e-05	3	116	2	23524339
Pubmed	Expression of protein kinase C isoenzymes alpha, betaI, and delta in subtypes of intercalated cells of mouse kidney.	PRKCA PRKCD	3.30e-05	3	116	2	16735462
Pubmed	Helios defines T cells being driven to tolerance in the periphery and thymus.	RAG1 ATP4A	3.30e-05	3	116	2	24740292
Pubmed	Over-expression of protein kinase C isoforms (α, δ, θ and ζ) in squamous cervical cancer.	PRKCA PRKCD	3.30e-05	3	116	2	21895402
Pubmed	Protein kinase C alpha -mediated negative feedback regulation is responsible for the termination of insulin-like growth factor I-induced activation of nuclear phospholipase C beta1 in Swiss 3T3 cells.	PRKCA PRKCD	3.30e-05	3	116	2	11278470
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	HK2 PARP4 TFCP2L1 LLGL2 UBE3A HERC4	3.59e-05	183	116	6	31932471
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	RALGAPA1 DMXL2 SYNGAP1 PRKCA PKN2 RAB2A DYNC1H1	4.59e-05	281	116	7	28706196
Pubmed	Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells.	PIK3C2G PRKCA PRKCD	4.60e-05	21	116	3	9446795
Pubmed	HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes.	PIK3C2G PRKCA PRKCD	5.32e-05	22	116	3	11154208
Pubmed	Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression.	AGO2 LRRK2	6.59e-05	4	116	2	20671708
Pubmed	Protein kinase C-dependent regulation of NAG-1/placental bone morphogenic protein/MIC-1 expression in LNCaP prostate carcinoma cells.	PRKCA PRKCD	6.59e-05	4	116	2	15757899
Pubmed	In silico modeling of the cryptic E2∼ubiquitin-binding site of E6-associated protein (E6AP)/UBE3A reveals the mechanism of polyubiquitin chain assembly.	UBA1 UBE3A	6.59e-05	4	116	2	28924046
Pubmed	PLK1 promotes cholesterol efflux and alleviates atherosclerosis by up-regulating ABCA1 and ABCG1 expression via the AMPK/PPARγ/LXRα pathway.	ABCG1 PLK1	6.59e-05	4	116	2	35981705
Pubmed	Identification of multiple, novel, protein kinase C-related gene products.	PRKCD PKN2	6.59e-05	4	116	2	7988719
Pubmed	Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes.	PRKCA PRKCD	6.59e-05	4	116	2	22318721
Pubmed	ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway.	ZNF521 BANK1	6.59e-05	4	116	2	26522721
Pubmed	Phosphorylation of synaptotagmin-1 controls a post-priming step in PKC-dependent presynaptic plasticity.	PRKCA DOC2B	6.59e-05	4	116	2	27091977
Pubmed	Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by calmodulin.	PRKCA PRKCD	6.59e-05	4	116	2	11042191
Pubmed	Protein kinase C as a tumor suppressor.	PRKCA PRKCD	6.59e-05	4	116	2	28476658
Pubmed	Interaction between protein kinase C and actin in megakaryocyte polyploidization.	PRKCA PRKCD	6.59e-05	4	116	2	10628374
Pubmed	The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?	ITIH1 PARP4	6.59e-05	4	116	2	10100603
Pubmed	PKCα and PKCδ regulate ADAM17-mediated ectodomain shedding of heparin binding-EGF through separate pathways.	PRKCA PRKCD	6.59e-05	4	116	2	21386996
Pubmed	SLC26A9 is a Cl(-) channel regulated by the WNK kinases.	SLC26A9 WNK3	6.59e-05	4	116	2	17673510
Pubmed	Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells.	RAG1 FLT3LG	6.59e-05	4	116	2	24054998
Pubmed	SETD2 Haploinsufficiency Enhances Germinal Center-Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis.	RAG1 SETD2	6.59e-05	4	116	2	35443279
Pubmed	Phosphorylation of p300 at serine 89 by protein kinase C.	PRKCA PRKCD	6.59e-05	4	116	2	11020388
Pubmed	α-Ketoglutarate stimulates pendrin-dependent Cl- absorption in the mouse CCD through protein kinase C.	PRKCA PRKCD	6.59e-05	4	116	2	29412702
Pubmed	Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function.	PRKCA PRKCD	6.59e-05	4	116	2	12682370
Pubmed	Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment.	PRKCD PKN2	6.59e-05	4	116	2	11781095
Pubmed	Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta.	RAG1 PRKCD	6.59e-05	4	116	2	11976687
Pubmed	Selective thymus settling regulated by cytokine and chemokine receptors.	FLT3LG CCR9	6.59e-05	4	116	2	17277104
Pubmed	Heterologous activation of protein kinase C stimulates phosphorylation of delta-opioid receptor at serine 344, resulting in beta-arrestin- and clathrin-mediated receptor internalization.	PRKCA PRKCD	6.59e-05	4	116	2	11085981
Pubmed	Commensal bacteria direct selective cargo sorting to promote symbiosis.	LRRK2 RAB2A	6.59e-05	4	116	2	26237551
Pubmed	The role of protein kinase D in neurotensin secretion mediated by protein kinase C-alpha/-delta and Rho/Rho kinase.	PRKCA PRKCD	6.59e-05	4	116	2	15123666
Pubmed	Setd2 determines distinct properties of intestinal ILC3 subsets to regulate intestinal immunity.	RAG1 SETD2	6.59e-05	4	116	2	35294891
Pubmed	Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta.	PRKCA PRKCD	6.59e-05	4	116	2	10770950
Pubmed	Selective association of protein kinase C with 14-3-3 zeta in neuronally differentiated PC12 Cells. Stimulatory and inhibitory effect of 14-3-3 zeta in vivo.	PRKCA PRKCD	6.59e-05	4	116	2	11950841
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	IFT172 FRMPD1 ERBIN LRIG3 NISCH DOCK7 CHD6 DYNC1H1	6.94e-05	407	116	8	12693553
Pubmed	Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120.	PIK3C2G PRKCA PRKCD	7.88e-05	25	116	3	15689238
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	AGO2 ERBIN SETD2 UBA1 DOCK7 PKN2 PLK1 CNOT1 DYNC1H1	9.74e-05	549	116	9	38280479
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	RALGAPA1 AGO2 ARHGAP26 FRMPD1 ADGRV1 CPT1A ERBIN ITIH1	1.02e-04	430	116	8	32581705
Pubmed	Protein kinase C isoforms have differential roles in the regulation of human sebocyte biology.	PRKCA PRKCD	1.10e-04	5	116	2	22475757
Pubmed	Characterization of PDK2 activity against protein kinase B gamma.	PRKCA PRKCD	1.10e-04	5	116	2	12162751
Pubmed	Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2.	PRKCA PRKCD	1.10e-04	5	116	2	17392515
Pubmed	The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness.	RAG1 UBE2F	1.10e-04	5	116	2	35641500
Interaction	GARIN1A interactions	GARIN1A RAB2B RAB2A	1.66e-06	5	112	3	int:GARIN1A
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	CACNA2D2 TOPAZ1 CCR9 ITIH1 SETD2 NISCH PRKCD	1.68e-05	316	116	7	chr3p21
GeneFamily	C2 domain containing protein kinases	PRKCA PRKCD PKN2	8.72e-06	10	77	3	835
GeneFamily	Synaptotagmin like tandem C2 proteins	SYTL2 DOC2B	7.88e-04	10	77	2	822
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP26 SYTL2 LRRK2 PARP4 TFCP2L1 LLGL2 ADGRF1 HYDIN	4.41e-08	194	116	8	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	COVID-19-kidney-CD-PC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NEXMIF SYTL2 TFCP2L1 TRPM3 PIK3C2G PRKCA ADGRF1	6.32e-07	188	116	7	8f9996c3f3b27efaaae8960a66af77412de9c7ef
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYTL2 LRRK2 MYRFL TFCP2L1 LLGL2 ADGRF1 HYDIN	6.78e-07	190	116	7	3fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA2D2 LRRK2 SLC26A9 ADGRV1 TFCP2L1 PRKCA MVD	7.27e-07	192	116	7	cc9911e182a289779a2612bc213daae5607689e7
ToppCell	3'-Adult-Distal_Rectal-Epithelial-goblet-BEST2+_Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SYTL2 FER1L6 ENO4 ZBTB49 ADGRF1 RAB2A	3.82e-06	159	116	6	6ec5489d55667e53bd9c021ada7de458bfef43a3
ToppCell	3'-Adult-Distal_Rectal-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SYTL2 FER1L6 ENO4 ZBTB49 ADGRF1 RAB2A	4.25e-06	162	116	6	075f73ff10e1a7f5695e014e47acc4db513e9cfb
ToppCell	droplet-Heart-nan-18m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRV1 MTMR4 RAVER2 TSSK4 ARHGAP33 DOC2B	4.89e-06	166	116	6	9adceb746e67e955fd8b3e0984f4eed44b64a270
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FER1L6 TFCP2L1 PIK3C2G PRKCA ADGRF1 WNK3	6.20e-06	173	116	6	0bc2aacae60c6d3276b0949eb0748b4ac1f56e54
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA2D2 NEXMIF SYTL2 PIK3C2G PRKCA DOC2B	7.53e-06	179	116	6	d3438fed0d85d5ed5afa8ff820c45143d77b6c0d
ToppCell	COVID-19_Mild-gd_T\|COVID-19_Mild / Disease condition and Cell class	CACNA2D2 ARHGAP26 SYTL2 ERBIN PTP4A2 TFCP2L1	8.54e-06	183	116	6	f593a89b0aa8fffdfa403769916facfd30358521
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 TRPM3 PIK3C2G DOCK7 PRKCA ADGRF1	9.66e-06	187	116	6	2d17408b3b5f09d135084fd7ccce98e6b5ca632b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM3 PIK3C2G DOCK7 PRKCA ADGRF1 DOC2B	9.96e-06	188	116	6	58ccb31cdf43167872ef0fc737e6f9c51ee2e060
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTP4A2 LPCAT2 TRPM3 PIK3C2G PRKCA DOC2B	9.96e-06	188	116	6	e30a4ddac0da8cdcf621d98e28e3895cd9307e7a
ToppCell	Adult\|World / Lineage, Cell type, age group and donor	DMXL2 CACNA2D2 CPT1A LLGL2 ADGRF1 KYNU	1.03e-05	189	116	6	5cd285bfad973125d46d704fec18b21266a63379
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 TRPM3 PIK3C2G DOCK7 PRKCA ADGRF1	1.03e-05	189	116	6	532aaf02b364c5c4f58a2021c7c21d86df3875c9
ToppCell	facs-Thymus-Epithelium-3m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAG1 CCR9 OTOP2 MGAT5 ALDH3A2	1.03e-05	110	116	5	3a641dced828ed97a8eea70d0a7b76f33630c9be
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTP4A2 LPCAT2 TRPM3 PIK3C2G PRKCA DOC2B	1.06e-05	190	116	6	11d3c31167ea71809b4cc3757a0c6ea54a448602
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NEXMIF SYTL2 LPCAT2 TRPM3 PIK3C2G PRKCA	1.06e-05	190	116	6	b7f8c2bb9459f1d7c1690069dd5a25a81a57cc84
ToppCell	COVID-19-lung-AT2\|lung / Disease (COVID-19 only), tissue and cell type	CACNA2D2 LRRK2 SLC26A9 ADGRV1 TFCP2L1 ADGRF1	1.09e-05	191	116	6	276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 TRPM3 PIK3C2G PRKCA ADGRF1 DOC2B	1.12e-05	192	116	6	40f44ac4ab673ee6156abdd2074a60b9de3281ad
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTP4A2 LPCAT2 TRPM3 PIK3C2G PRKCA DOC2B	1.12e-05	192	116	6	fd08ae787e936cfdb1ab8f19b0fd63005b462709
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTP4A2 LPCAT2 TRPM3 PIK3C2G PRKCA DOC2B	1.12e-05	192	116	6	bae236c9f1fac77bce28d0a9cf090100d391ff77
ToppCell	COVID-19-kidney-CD-PC\|kidney / Disease (COVID-19 only), tissue and cell type	NEXMIF SYTL2 LPCAT2 TRPM3 PIK3C2G PRKCA	1.16e-05	193	116	6	738689d009e4b118d7ce3171a207294b95cbe78b
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NEXMIF SYTL2 PIK3C2G PRKCA ADGRF1 DOC2B	1.19e-05	194	116	6	4579b4a44f7c731553a284843c296866027d7c0e
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NEXMIF SYTL2 PIK3C2G PRKCA ADGRF1 DOC2B	1.23e-05	195	116	6	3d6d3de8ada6dce3dc789c15b50cc066e7100496
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYTL2 LRRK2 USP43 TFCP2L1 LLGL2 HYDIN	1.30e-05	197	116	6	7e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell	COVID-19-kidney-Macrophages\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DMXL2 HK2 ARHGAP26 ZNF267 DCSTAMP KYNU	1.30e-05	197	116	6	3912301018d0863144dcfac8d1fa8adc081748d7
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYTL2 FER1L6 TFCP2L1 ADGRF1 HYDIN MAP3K19	1.30e-05	197	116	6	5c4cee914baf7cb43e9cb99cc9e3ae823856dc15
ToppCell	Fetal_29-31_weeks-Immune-alveolar_macrophage_(MARCO_positive)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DMXL2 HK2 DCSTAMP ABCG1 PRSS21 KYNU	1.34e-05	198	116	6	ab70bf89690410221ec7aa3149bb50ac34433f99
ToppCell	NS-critical-LOC-Epithelial-Secretory_LYPD2\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SYTL2 FER1L6 LRIG3 TFCP2L1 ALDH3A2 ADGRF1	1.34e-05	198	116	6	4a481e1edb80b950c823ed926842cd5132cfb27f
ToppCell	Caecum-(6)_Macrophage-(61)_LYVE1_Macrophage\|Caecum / shred on region, Cell_type, and subtype	DMXL2 TMEM144 LRRK2 LPCAT2 OR10K1 KYNU	1.34e-05	198	116	6	e684c3934c163aef4d284b69435832d2c9614f2a
ToppCell	Caecum-Macrophage-LYVE1_Macrophage\|Caecum / Region, Cell class and subclass	DMXL2 TMEM144 LRRK2 LPCAT2 OR10K1 KYNU	1.34e-05	198	116	6	a92c0cacb775aca6bbb302bd9e22c081a112a44d
ToppCell	Cerebellum-Macroglia-OLIGODENDROCYTE-O1-Trf\|Cerebellum / BrainAtlas - Mouse McCarroll V32	GARIN1A SLC26A9 ADGRV1 TDRD6	2.22e-05	63	116	4	83e1c91f830aadaf13e13254ce30189fd434bcc9
ToppCell	Cerebellum-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendroyte.Trf.Il33_(Il33)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	GARIN1A SLC26A9 ADGRV1 TDRD6	2.22e-05	63	116	4	f2532b1aa117eea550f0ae0b599780c4fe621407
ToppCell	Cerebellum-Macroglia-OLIGODENDROCYTE-O1\|Cerebellum / BrainAtlas - Mouse McCarroll V32	GARIN1A SLC26A9 ADGRV1 TDRD6	2.22e-05	63	116	4	0643435edf3280daf38c950e5bec287a9d5cb517
ToppCell	Cerebellum-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendroyte.Trf.Il33_(Il33)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	GARIN1A SLC26A9 ADGRV1 TDRD6	2.22e-05	63	116	4	71c3afda6534401320791b714e3e2fe83094c914
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE\|Thalamus / BrainAtlas - Mouse McCarroll V32	TMEM144 ADGRV1 ERBIN DOCK5 TDRD6	2.23e-05	129	116	5	b3cb0c10659d1216b8f7de3aa1f9aac101cb65dd
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYTL2 TFCP2L1 LPCAT2 TRPM3 PIK3C2G	3.90e-05	145	116	5	bfa196ac1db7acbfcbb2ba9f137036a95e16e091
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	TMEM144 ZNF521 SLC26A9 ZNF236 SNX32	5.04e-05	153	116	5	433b971c98da321204e065019db4e7825c7587cd
ToppCell	Severe-B_naive-1\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	MTERF4 ERBIN CEMIP2 MGAT5 BANK1	6.05e-05	159	116	5	2881b054bbeb479221ee3c38bbd9b0815b123579
ToppCell	droplet-Marrow-nan-21m-Hematologic-erythroid_progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZBTB49 EXOC3L4 TSSK4 ALOX12 BANK1	6.61e-05	162	116	5	d0ffebf5adee8a3ac9b81a4b793184f54010489a
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-CR-CR_Lhx5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CACNA2D2 LRIG3 PIK3C2G HYDIN	7.57e-05	86	116	4	2990429ed4438f41ff03f4a9cae8863a528fdd81
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-CR\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CACNA2D2 LRIG3 PIK3C2G HYDIN	7.57e-05	86	116	4	97467708c90a4bd49deafe3e2ec495c56b448ce1
ToppCell	droplet-Marrow-BM-1m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AGO2 LRIG3 GVINP1 TSSK4 ATP4A	7.85e-05	168	116	5	2e88d9cb7c80a4656fab290db8b45a5a0599d769
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NEXMIF LRRK2 FANCB TRPM3 PIK3C2G	7.85e-05	168	116	5	08f6e171a1ea5cf65149744296d0fcd6c7b9684e
ToppCell	Control-CD4+_T\|World / Disease group and Cell class	FLT3LG NEXMIF USP43 DCSTAMP MGAT5	8.07e-05	169	116	5	e330d85bd37a1bd1c3d8d29ddd8a2c1020a62a83
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	USP43 FER1L6 TFCP2L1 ADGRF1 KYNU	8.07e-05	169	116	5	4b3a7b4a497178799b6b2f0b744f5fb752cee31a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYTL2 LLGL2 TRPM3 PIK3C2G PRKCA	8.07e-05	169	116	5	0332f539a2f7d6dcd081a5d2f567290721f5a329
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	USP43 FER1L6 TFCP2L1 ADGRF1 KYNU	8.07e-05	169	116	5	a4fd646b9bf87225131fca530bd6b52df9eaf489
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRRC63 SYTL2 LPCAT2 TRPM3 PIK3C2G	8.30e-05	170	116	5	928e42c51a7079c506f21c669c4e4c1a0df84d77
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	USP43 ZNF521 LRIG3 TRPM3 KCNH1	9.01e-05	173	116	5	8335b77f730ed43fc348a005566e73a103c6774b
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_SEMA6D\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRRK2 USP43 ZNF521 TRPM3 KCNH1	9.01e-05	173	116	5	9a2d42f8d9cb834856522661d524abb91c4637c5
ToppCell	facs-Marrow-KLS-18m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEMIP2 ALDH3A2 PLK1 NQO2 ARHGAP33	9.26e-05	174	116	5	9d5dcd46cf346c381dea68ada6665f7fb68114a3
ToppCell	facs-Marrow-KLS-18m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEMIP2 ALDH3A2 PLK1 NQO2 ARHGAP33	9.26e-05	174	116	5	53cec5c666c45278a71c21dd9c62a052a97e0fdf
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRRK2 USP43 TRPM3 PIK3C2G KCNH1	9.26e-05	174	116	5	b3cd22e717d178269e6d5bd5ed7b2d945cd8ea25
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FER1L6 TFCP2L1 PIK3C2G PRKCD ADGRF1	1.00e-04	177	116	5	8e4005fad50e6f919da175f3b9ae58849dbd60b1
ToppCell	facs-Marrow-Granulocytes-24m-Hematologic-MPP_Fraction_B\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC63 DCSTAMP TFCP2L1 EXOC3L4 ADGRF1	1.00e-04	177	116	5	4a697866ed542d3201714234cee03451adf1dcc9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 TRPM3 PIK3C2G PRKCA ADGRF1	1.00e-04	177	116	5	f35b04c3557ebbdeba37dec54c8f45880eafb422
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP26 LRRK2 PARP4 ADGRF1 HYDIN	1.03e-04	178	116	5	c20f050344a2e120e685e2a7fe36c6dfc1dc37b6
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYTL2 ADGRV1 FER1L6 TFCP2L1 ADGRF1	1.06e-04	179	116	5	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	human_hepatoblastoma-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	SYTL2 ZNF521 CDKL1 CEMIP2 TRPM3	1.06e-04	179	116	5	14fc8ccb6b215063d747643f47d780d2b237eb67
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LPCAT2 TRPM3 PIK3C2G PRKCA DOC2B	1.09e-04	180	116	5	023ec0b080c8a5cd0f36e83c6b17d4be3c01edb5
ToppCell	facs-Lung-3m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CEMIP2 LPCAT2 KCNH1 CALCRL PLK1	1.11e-04	181	116	5	72c28baf4fd417ff4a7068603830d55074960144
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LRRC63 LRRK2 PARP4 LPCAT2 HYDIN	1.11e-04	181	116	5	071f9bb5d39070cdc473d9b0e094d196bc702b56
ToppCell	facs-Lung-3m-Endothelial-venous_endothelial-vein_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CEMIP2 LPCAT2 KCNH1 CALCRL PLK1	1.11e-04	181	116	5	2ac4d3e8987d5a009d7908d8787e18165826202a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM3 PIK3C2G DOCK7 PRKCA DOC2B	1.11e-04	181	116	5	b7c85fbef3c06d5dc32a2a58f8d3dfabf1d79d9f
ToppCell	facs-Lung-3m-Endothelial-venous_endothelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CEMIP2 LPCAT2 KCNH1 CALCRL PLK1	1.11e-04	181	116	5	2628c7ac345eaaeecf8e34617e81948925962cb9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CEMIP2 TRPM3 PIK3C2G DOCK7 PRKCA	1.14e-04	182	116	5	f96095b81188b52db8fcfca4837129cfcd9bd7b7
ToppCell	COPD-Epithelial-ATII\|World / Disease state, Lineage and Cell class	CACNA2D2 LRRK2 SLC26A9 ADGRV1 TFCP2L1	1.17e-04	183	116	5	8e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYTL2 TFCP2L1 TRPM3 PIK3C2G PRKCA	1.17e-04	183	116	5	b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYRFL TRPM3 PIK3C2G PRKCA DOC2B	1.17e-04	183	116	5	d340ab5a77e8d819a1dfb4ca3e9a4b9bc988923c
ToppCell	367C-Epithelial_cells-Epithelial-A_(AT2)\|367C / Donor, Lineage, Cell class and subclass (all cells)	CACNA2D2 LRRK2 SLC26A9 ADGRV1 TFCP2L1	1.20e-04	184	116	5	0ba243cbf69b4fe6ae100a7f0314317bec38026c
ToppCell	COVID-19-Epithelial_cells-AT2\|COVID-19 / group, cell type (main and fine annotations)	CACNA2D2 LRRK2 SLC26A9 ADGRV1 ADGRF1	1.20e-04	184	116	5	369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCell	367C-Epithelial_cells-Epithelial-A_(AT2)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	CACNA2D2 LRRK2 SLC26A9 ADGRV1 TFCP2L1	1.20e-04	184	116	5	2a8338e94937686a148b5433515700ca0f674058
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEMIP2 ENO4 RBM12 KYNU HYDIN	1.23e-04	185	116	5	05bc89a566b0db90ae06506e067190a4739a0974
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTP4A2 TRPM3 PIK3C2G PRKCA DOC2B	1.23e-04	185	116	5	a0a629e5d2b65f670ea907bd3f5e3caf17687d8f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 TRPM3 PIK3C2G DOCK7 PRKCA	1.23e-04	185	116	5	d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCell	5'-Adult-Distal_Rectal-Epithelial-Tuft-related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DMXL2 HK2 OTOP2 TFCP2L1 LLGL2	1.27e-04	186	116	5	4046b701aa29712d9f7c774f8955215122c3c003
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LRRC63 ARHGAP26 LRRK2 ABCG1 HYDIN	1.27e-04	186	116	5	5c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCell	5'-Adult-Distal_Rectal-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DMXL2 HK2 OTOP2 TFCP2L1 LLGL2	1.27e-04	186	116	5	bd5837033c1ffcbe5dd30195cc4846a2ba351bcd
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA2D2 LRRK2 ADGRV1 TFCP2L1 PIK3C2G	1.30e-04	187	116	5	5df9e1f5ca32217af255e76e6fb5afa346337811
ToppCell	COPD-Epithelial-ATII\|Epithelial / Disease state, Lineage and Cell class	CACNA2D2 LRRK2 SLC26A9 CEMIP2 TFCP2L1	1.30e-04	187	116	5	030af361f8bdcd0aff4ec1922702833325cf74d8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA2D2 LPCAT2 TRPM3 PIK3C2G DOC2B	1.30e-04	187	116	5	f6217d0dd425eac76900b44a4e48f45475f3ac36
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA2D2 LPCAT2 TRPM3 PIK3C2G PRKCA	1.30e-04	187	116	5	b7689e7f6511920cd2beff27389555fddf685f61
ToppCell	Thalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Thalamus / BrainAtlas - Mouse McCarroll V32	DCSTAMP PIK3C2G RAVER2 PRKCD	1.36e-04	100	116	4	20675fc2ffc5ab63047d38da083b50d470f3db19
ToppCell	Thalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6\|Thalamus / BrainAtlas - Mouse McCarroll V32	DCSTAMP PIK3C2G RAVER2 PRKCD	1.36e-04	100	116	4	1de3895e16f14ff32b901b18ce14d965afaa7e76
ToppCell	Thalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Rora\|Thalamus / BrainAtlas - Mouse McCarroll V32	DCSTAMP PIK3C2G RAVER2 PRKCD	1.36e-04	100	116	4	ff1bdb511700a041a90034d1d30dfc25f51d6c82
ToppCell	COVID-19-kidney-VWF+PLVAP+VCAM1+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ARHGAP26 ZNF521 ABCG1 CALCRL DOC2B	1.36e-04	189	116	5	c121817ddad164e9cfe382c43d0cbc9215508d02
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D231\|Adult / Lineage, Cell type, age group and donor	CACNA2D2 LRRK2 SLC26A9 ADGRV1 ADGRF1	1.36e-04	189	116	5	dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NEXMIF LRRK2 ADGRV1 TFCP2L1 LLGL2	1.36e-04	189	116	5	e059be2965cca70ff5576df055d0af1775b76e00
ToppCell	COVID-19-Heart-EC_(POSTN)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ARHGAP26 ZNF521 CEMIP2 LRIG3 CALCRL	1.36e-04	189	116	5	7346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LRRC63 LRRK2 PARP4 ABCG1 HYDIN	1.36e-04	189	116	5	904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYTL2 LPCAT2 TRPM3 PIK3C2G DOC2B	1.36e-04	189	116	5	bfc76a72b600d641c8fe58346e5d8986c34f3981
ToppCell	(2)_NK/T-(210)_NKT_cell\|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)	ARHGAP26 SYTL2 ERBIN LLGL2 UBE2F	1.36e-04	189	116	5	fa72e87e1e8cd7cbddae7b47e19cf90d181820a7
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM3 PIK3C2G DOCK7 PRKCA DOC2B	1.36e-04	189	116	5	c9565e962a13a7713056ec3dbb1b67d24f9889c7
ToppCell	(2)_NK/T-(21)_NKT_cell\|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)	ARHGAP26 SYTL2 ERBIN LLGL2 UBE2F	1.36e-04	189	116	5	b37ad24898a14a4a3b2d6cea2637de2471f76e20
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP26 ZNF521 CEMIP2 CALCRL DOC2B	1.40e-04	190	116	5	656483751e4bf137e4e4bfb2a03a478a8f7fcb63
ToppCell	pdx-Tumor_cells-T8\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	CPT1A ITIH1 FER1L6 EXOC3L4 KYNU	1.40e-04	190	116	5	b05db0de9b6ae01dd30074453f7de44f7397631e
ToppCell	COVID-19-lung-AT2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA2D2 LRRK2 SLC26A9 ADGRV1 ADGRF1	1.40e-04	190	116	5	27a1a86620fe9b5ee930d388b32352206485e6d0
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYTL2 LPCAT2 TRPM3 PIK3C2G PRKCA	1.40e-04	190	116	5	078f4be52fa4cc8dd9c8d7a2b6d9631c3d902285
Drug	Etilefrine hydrochloride [534-87-2]; Up 200; 18.4uM; HL60; HT_HG-U133A	ARHGAP26 VPS50 SYTL2 DCSTAMP ZZEF1 CEMIP2 ABCG1 KYNU ALOX12	3.54e-07	181	115	9	2930_UP
Disease	platelet component distribution width	ZNF211 LRRK2 ZZEF1 KCTD17 DOCK5 SETD2 TRPM3 EXOC3L4 DOCK7 PKN2 ADGRF1 KYNU	3.08e-05	755	112	12	EFO_0007984
Disease	Epilepsy	CACNA2D2 NEXMIF SYNGAP1 UBE3A KCNH1	6.15e-05	109	112	5	C0014544
Disease	hypertension (implicated_via_orthology)	RAG1 NISCH PRKCA PRKCD KYNU	1.31e-04	128	112	5	DOID:10763 (implicated_via_orthology)
Disease	macrophage inflammatory protein 1b measurement	CACNA2D2 TOPAZ1 CCR9 LRIG3 SETD2	1.75e-04	136	112	5	EFO_0008219
Disease	Squamous cell carcinoma of lung	ATR PLK1 WNK3	2.44e-04	32	112	3	C0149782
Disease	Epilepsy, Cryptogenic	NEXMIF SYNGAP1 UBE3A KCNH1	2.74e-04	82	112	4	C0086237
Disease	response to selective serotonin reuptake inhibitor	SLC26A9 OR52B4 TRPM3 KYNU	2.74e-04	82	112	4	EFO_0005658
Disease	Awakening Epilepsy	NEXMIF SYNGAP1 UBE3A KCNH1	2.74e-04	82	112	4	C0751111
Disease	Aura	NEXMIF SYNGAP1 UBE3A KCNH1	2.74e-04	82	112	4	C0236018
Disease	autism spectrum disorder (implicated_via_orthology)	NEXMIF SYNGAP1 UBE3A CHD6 TPH1	2.92e-04	152	112	5	DOID:0060041 (implicated_via_orthology)
Disease	epilepsy (implicated_via_orthology)	CACNA2D2 UBE3A KCNH1 ATP4A DYNC1H1	4.03e-04	163	112	5	DOID:1826 (implicated_via_orthology)
Disease	Neurodevelopmental Disorders	NEXMIF SYNGAP1 SETD2 KCNH1	4.43e-04	93	112	4	C1535926
Disease	Osteitis Deformans	DCSTAMP ZNF687	5.05e-04	9	112	2	C0029401
Disease	insulin sensitivity measurement, glucose homeostasis measurement	DOCK5 MGAT5 PKN2	5.88e-04	43	112	3	EFO_0004471, EFO_0006896
Disease	Psychotic Disorders	ARHGAP26 RBM12 PRKCA NQO2	6.05e-04	101	112	4	C0033975
Disease	Intestinal Neoplasms	PRKCA PRKCD	9.19e-04	12	112	2	C0021841
Disease	Intestinal Cancer	PRKCA PRKCD	9.19e-04	12	112	2	C0346627
Disease	mean platelet volume	LRRK2 FRYL DOCK5 SETD2 TRPM3 EXOC3L4 DOCK7 ALDH3A2 KYNU ALOX12 BANK1	1.74e-03	1020	112	11	EFO_0004584
Disease	aspartate aminotransferase measurement	CACNA2D2 CDKL1 ITIH1 MGAT5 TRPM3 PRKCA PKN2 CALCRL RAB2A BANK1	2.35e-03	904	112	10	EFO_0004736
Disease	cognitive function measurement, self reported educational attainment	DMXL2 AGO2 CACNA2D2 ITIH1 MTMR4 BANK1	2.39e-03	355	112	6	EFO_0004784, EFO_0008354
Disease	obesity (biomarker_via_orthology)	HK2 CPT1A PRKCD ALOX12	2.42e-03	147	112	4	DOID:9970 (biomarker_via_orthology)
Disease	Non-alcoholic Fatty Liver Disease	CPT1A PRKCA PRKCD	2.42e-03	70	112	3	C0400966
Disease	Nonalcoholic Steatohepatitis	CPT1A PRKCA PRKCD	2.42e-03	70	112	3	C3241937
Disease	CCL4 measurement	CCR9 SETD2	2.59e-03	20	112	2	EFO_0004751
Disease	ST2 protein measurement	MGAT5 BANK1	2.86e-03	21	112	2	EFO_0010599
Disease	testosterone measurement	ARHGAP26 USP43 RYK DOCK5 PTP4A2 MGAT5 NISCH PRKCA HERC4 ZNF654 BANK1 TPH1	3.33e-03	1275	112	12	EFO_0004908

Protein segments in the cluster

Peptide	Gene	Start	Entry
ICSQNKYTHFKELPT	BANK1	331	Q8NDB2
PLVTATCSFQKHLLQ	EXOC3L4	506	Q17RC7
HCSLEQVPKEIFTFE	ERBIN	31	Q96RT1
TCTLVFLTPKIQFAN	nan	356	Q9N2K0
TCTLVFLTPKIQFAN	nan	356	Q9N2J8
SFNEKAQPVSCFTHL	CACNA2D2	331	Q9NY47
CTIHQPSAKLFELFD	ABCG1	271	P45844
FFSKIESNLSQPHCV	ADGRF1	521	Q5T601
QVKIFPSCLFVHQNV	GVINP1	1601	Q7Z2Y8
TFIFHLTLQKPSANV	ADGRV1	111	Q8WXG9
LINFHISSKFSCPET	CPT1A	731	P50416
FDTFSHQRPCLLKSL	ALDH3A2	416	P51648
IAPTEILFCTLNSHK	GIPC3	71	Q8TF64
HQVIIKSCNPVAFSF	DMXL2	1826	Q8TDJ6
FAPQRQCTEVHLKSF	AGO2	456	Q9UKV8
SAKVCAHITNIPFSI	RBM12	541	Q9NTZ6
VDFPEHFVKSISCQI	RAG1	281	P15918
IFSSVHKPVFCQLAQ	RAVER2	251	Q9HCJ3
CLLLQFTDKRFQPVH	RAB2A	21	P61019
CLLLQFTDKRFQPVH	RAB2B	21	Q8WUD1
SLECFPVKLNNLIHT	PIK3C2G	1161	O75747
FFHATLIKAVPVNCT	KBTBD3	496	Q8NAB2
QVFVKCTLHPSDQLA	LLGL2	621	Q6P1M3
FTIHLTVNPQSKVTF	ITIH1	146	P19827
SQLICEPSFFQHLNK	MGAT5	656	Q09328
ENPFLTHLICTFQTK	PRKCD	406	Q05655
HICTFKQTLENYRTP	LRIG3	1096	Q6UXM1
FPCHQTKLDESFLVS	HK2	156	P52789
VNTEIHFVTKCAFQP	FLT3LG	101	P49771
IPACFTQLFFIHTLS	OR51G1	96	Q8NGK1
KRLTFCQNNIIPHTF	OR52B4	166	Q8NGK2
TCNLRAKSFSIHFPL	DCSTAMP	126	Q9H295
LIQHFDSPTQFCKET	FRYL	2111	O94915
VSHTCFNLLDLPKYT	HERC4	1021	Q5GLZ8
INTTEPLIVFQCKFT	MYRFL	816	Q96LU7
FLCTFSDITAFKQPI	KCNH1	126	O95259
LSCKVHVASVNNFPT	MVD	106	P53602
FPQQLCETLKSLTHL	LRRK2	1026	Q5S007
QSFILLKPVFHCLNE	TUBGCP4	571	Q9UGJ1
LTKIQFENNFTHPCF	LRRC63	461	Q05C16
PVSFQSQSQLCHFLT	ALOX12	516	P18054
KFSFSLNPQCTHIIL	PARP4	36	Q9UKK3
TLHFCGFKVLAPQIS	NQO2	176	P16083
EFLCVVSKELHSTPN	KCTD17	186	Q8N5Z5
SVHQLLKQFPCLFEF	MTMR4	476	Q9NYA4
TSHSPVCQDVLKFIS	IFT172	1721	Q9UG01
SSFFECQSAIKILHP	OTOP2	126	Q7RTS6
TEFVLTGFLHQPDCK	OR5H6	26	Q8NGV6
LLAAFHKSCFQITSP	FANCB	651	Q8NB91
LQTCHVFSLPKEVQT	LPCAT2	506	Q7L5N7
NQCPHIFSKALVVSV	OCR1	11	Q9BZK8
PAFLQDIHSVSSLCK	ARHGAP33	376	O14559
KPICQFLVESLHSSQ	ATR	931	Q13535
FPHTLICSLNNTSLI	HYDIN	581	Q4G0P3
NHTKTFSICLEKQLP	DOC2B	241	Q14184
LSVLFCKFIQSIPDN	DOCK5	836	Q9H7D0
HCFATQRALVSKFPE	DOCK7	1526	Q96N67
HCFTETSKLQYLPQL	CDKL1	316	Q00532
HLSLPDVTCENFISK	CHD6	1671	Q8TD26
LESFCTNHIQETAPK	FRMPD1	1056	Q5SYB0
VTQTIAFFHSCLNPV	CCR9	301	P51686
CSHFQVKVKETPQFL	CEMIP2	456	Q9UHN6
PLALFTSKECHYSIQ	CSAD	181	Q9Y600
FVIQIPHSEEKICFT	ITIH6	1086	Q6UXX5
FPKNVCSVVISTHFE	ENO4	96	A6NNW6
PFFKLCDEQLSSQSH	DYNC1H1	2071	Q14204
RPKFQQLVQCLTEFH	RYK	586	P34925
IPFNSTNKFQLSIHT	ATP4A	491	P20648
ATNPVSCKVSQFIHL	CALCRL	206	Q16602
IVCTIPSKFQETQHS	MAP3K19	386	Q56UN5
HFFCDISPVLKLASQ	OR10K1	176	Q8NGX5
LLCQLIHSPEFNLFS	GARIN1A	26	Q6NXP2
LSDPFAKVTFLSHCQ	FER1L6	846	Q2WGJ9
HLNSFVKCTILPDTS	SYTL2	811	Q9HCH5
FVNKILSSHQPLFSC	TAAR3P	16	Q9P1P4
TVQNLLKHCVDPTSF	UTP20	1376	O75691
CLKVDNHFNLLTTSP	TRIM43	376	Q96BQ3
LTPFQSACHFLVEKR	TDRD6	941	O60522
FPDPNKLHCFQLTVT	UBE2F	56	Q969M7
SIVFTFIDICKNLPH	SLC26A9	236	Q7LBE3
KPPFLTQLHSCFQTV	PRKCA	396	P17252
LFTVQQVTKILHSCP	MTERF4	206	Q7Z6M4
FLAHCSPKLVIQQSI	NEXMIF	1026	Q5QGS0
SLHAVFSLLVNFVPC	ARHGAP26	721	Q9UNA1
LVSTTHCFLNKSQAP	PRSS47P	116	A8MTI9
RHPFLVNLFACFQTK	PKN2	716	Q16513
FIQVHCISTEFTPRK	TFCP2L1	166	Q9NZI6
LSFIQHSLINPEIFC	CNOT1	406	A5YKK6
LTAFCNTFHILRPTK	CNOT1	2016	A5YKK6
LCPVKSNFSILQLHE	VPS50	471	Q96JG6
TVFQELNKLYPTHAC	TPH1	176	P17752
TFPANHTISQECKNL	TSSK4	256	Q6SA08
LKQSNTFDPFLCVSL	USP43	256	Q70EL4
HTCFNVLLLPEYSSK	UBE3A	841	Q05086
HEKTFTDPLSLQNCV	ZNF177	261	Q13360
DIVNTIIKHCSPQFF	RALGAPA1	1186	Q6GYQ0
IKPVHSSILGQEFCF	SYNGAP1	206	Q96PV0
IFLFIKSEIPNNTCS	TMEM144	141	Q7Z5S9
FLITHNPTNATLNKF	PTP4A2	16	Q12974
HISLQKINTRCLPFF	TRPM3	316	Q9HCF6
AKPFTCFSNLIVHER	ZNF267	526	Q14586
SQTFDSPAKLQCHLI	ZNF521	1231	Q96K83
NSPFHISQCFVLKLS	NISCH	1216	Q9Y2I1
TKSHRIFQAQCSFPE	ZNF654	836	Q8IZM8
SFTQSCIVHVSEKPF	ZNF211	171	Q13398
ICTLKNFPNAIEHTL	UBA1	631	P22314
EIKQSHSFSLQTPCS	SETD2	581	Q9BYW2
ICEKVFNIPSSFQIH	ZNF124	126	Q15973
HSVLKLQNPETCEIF	TOPAZ1	1061	Q8N9V7
VIATFTDHCIKQLPF	ZZEF1	2221	O43149
ICLLSFPKESQFQRH	ZNF236	41	Q9UL36
CPQTFNVEFNLTLHK	ZNF236	71	Q9UL36
FDQHLLPQRVSVFKC	ZNF687	846	Q8N1G0
KHIQPICLQASTFEF	PRSS21	151	Q9Y6M0
CLKVDNHFNLLTTSP	TRIM43B	376	A6NCK2
SLCHTFLKSATVVQP	ZBTB49	111	Q6ZSB9
AKISNQIFHERFTCP	WDR25	416	Q64LD2
KFTVQTKSCLPHFAQ	SNX32	41	Q86XE0
QINFFQDHTKLILCP	PLK1	531	P53350
TIENNPCHRALFTSK	WNK3	921	Q9BYP7
CQLTITFSVPNKDVF	KYNU	401	Q16719