Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	SOX4 ZNF627 TSHZ3 HIF1A ZNF555 ZNF530 ZNF670 TSHZ2 ZNF559 ZNF689 HDX ZNF267 ZNF69 TBXT ZNF700 ZNF441 ZNF563 ZNF557	2.76e-07	1412	64	18	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	SOX4 ATXN3L ZNF627 HIF1A ZNF555 ZNF530 ZNF670 ZNF559 ZNF689 HDX ZNF267 ZNF69 TBXT ZNF700 ZNF441 ZNF563 ZNF557	2.23e-06	1459	64	17	GO:0000977
HumanPheno	Skin detachment	COL17A1 ITGB4	1.05e-05	2	17	2	HP:0032156
HumanPheno	Atrophic, patchy alopecia	COL17A1 ITGB4	3.14e-05	3	17	2	HP:0004529
HumanPheno	Abnormal muscle fiber emerin	SYNE2 EMD	1.56e-04	6	17	2	HP:0030116
HumanPheno	Absent muscle fiber emerin	SYNE2 EMD	1.56e-04	6	17	2	HP:0030117
HumanPheno	Myotonia	HSPG2 SYNE2 EMD	1.73e-04	34	17	3	HP:0002486
HumanPheno	Decreased cervical spine flexion due to contractures of posterior cervical muscles	SYNE2 EMD	2.18e-04	7	17	2	HP:0004631
HumanPheno	Hypoplastic dermoepidermal hemidesmosomes	COL17A1 ITGB4	2.18e-04	7	17	2	HP:0020117
HumanPheno	Tetralogy of Fallot	SOX4 HSPG2 BRCA2 SPEN CHUK	2.59e-04	185	17	5	HP:0001636
HumanPheno	Abnormality of the scalp hair	SOX4 HSPG2 COL17A1 DOCK7 HUWE1 SPEN ITGB4	2.80e-04	433	17	7	HP:0100037
HumanPheno	Abnormal scalp morphology	SOX4 HSPG2 COL17A1 DOCK7 HUWE1 SPEN ITGB4	3.56e-04	450	17	7	HP:0001965
HumanPheno	Acral blistering	COL17A1 ITGB4	3.72e-04	9	17	2	HP:0031045
HumanPheno	Mitten deformity	COL17A1 ITGB4	3.72e-04	9	17	2	HP:0004057
HumanPheno	Abnormal dermatological laboratory findings	COL17A1 ITGB4	4.64e-04	10	17	2	HP:0003340
HumanPheno	Lamina lucida cleavage	COL17A1 ITGB4	4.64e-04	10	17	2	HP:0003341
HumanPheno	Dental enamel pits	COL17A1 ITGB4	4.64e-04	10	17	2	HP:0009722
HumanPheno	Abnormal blistering of the skin	HSPG2 COL17A1 SPEN ITGB4	4.67e-04	115	17	4	HP:0008066
HumanPheno	Pterygium	HSPG2 ITGB4 CHUK	4.87e-04	48	17	3	HP:0001059
HumanPheno	Ventricular escape rhythm	SYNE2 EMD	5.67e-04	11	17	2	HP:0005155
HumanPheno	Subepidermal blistering	COL17A1 ITGB4	5.67e-04	11	17	2	HP:0033804
HumanPheno	Abnormal dermoepidermal hemidesmosome morphology	COL17A1 ITGB4	5.67e-04	11	17	2	HP:0032449
HumanPheno	Axillary pterygium	ITGB4 CHUK	5.67e-04	11	17	2	HP:0001060
HumanPheno	Abnormal dermoepidermal junction morphology	COL17A1 ITGB4	6.78e-04	12	17	2	HP:0031538
HumanPheno	Sprengel anomaly	HSPG2 SYNE2 EMD	6.89e-04	54	17	3	HP:0000912
MousePheno	abnormal heart tube morphology	SOX4 HSPG2 HIF1A SHROOM3 TBXT	1.96e-06	68	43	5	MP:0000270
MousePheno	abnormal conotruncal ridge morphology	SOX4 HSPG2 SHROOM3	1.79e-05	17	43	3	MP:0010585
MousePheno	abnormal conotruncus morphology	SOX4 HSPG2 SHROOM3	2.14e-05	18	43	3	MP:0010583
Domain	KRAB	ZNF627 ZNF555 ZNF530 ZNF670 ZNF559 ZNF689 ZNF267 ZNF69 ZNF700 ZNF441 ZNF563 ZNF557	2.27e-09	358	63	12	PS50805
Domain	KRAB	ZNF627 ZNF555 ZNF530 ZNF670 ZNF559 ZNF689 ZNF267 ZNF69 ZNF700 ZNF441 ZNF563 ZNF557	2.27e-09	358	63	12	PF01352
Domain	KRAB	ZNF627 ZNF555 ZNF530 ZNF670 ZNF559 ZNF689 ZNF267 ZNF69 ZNF700 ZNF441 ZNF563 ZNF557	3.19e-09	369	63	12	SM00349
Domain	KRAB	ZNF627 ZNF555 ZNF530 ZNF670 ZNF559 ZNF689 ZNF267 ZNF69 ZNF700 ZNF441 ZNF563 ZNF557	3.29e-09	370	63	12	IPR001909
Domain	zf-C2H2	ZNF627 TSHZ3 ZNF555 ZNF530 ZNF670 TSHZ2 ZNF559 ZNF689 ZNF267 ZNF69 ZNF700 ZNF441 ZNF563 ZNF557	5.71e-08	693	63	14	PF00096
Domain	ZINC_FINGER_C2H2_2	ZNF627 TSHZ3 ZNF555 ZNF530 ZNF670 TSHZ2 ZNF559 ZNF689 ZNF267 ZNF69 ZNF700 ZNF441 ZNF563 ZNF557	2.25e-07	775	63	14	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF627 TSHZ3 ZNF555 ZNF530 ZNF670 TSHZ2 ZNF559 ZNF689 ZNF267 ZNF69 ZNF700 ZNF441 ZNF563 ZNF557	2.32e-07	777	63	14	PS00028
Domain	Znf_C2H2-like	ZNF627 TSHZ3 ZNF555 ZNF530 ZNF670 TSHZ2 ZNF559 ZNF689 ZNF267 ZNF69 ZNF700 ZNF441 ZNF563 ZNF557	3.12e-07	796	63	14	IPR015880
Domain	Znf_C2H2	ZNF627 TSHZ3 ZNF555 ZNF530 ZNF670 TSHZ2 ZNF559 ZNF689 ZNF267 ZNF69 ZNF700 ZNF441 ZNF563 ZNF557	3.57e-07	805	63	14	IPR007087
Domain	ZnF_C2H2	ZNF627 TSHZ3 ZNF555 ZNF530 ZNF670 TSHZ2 ZNF559 ZNF689 ZNF267 ZNF69 ZNF700 ZNF441 ZNF563 ZNF557	3.73e-07	808	63	14	SM00355
Domain	-	ZNF627 ZNF555 ZNF530 ZNF670 ZNF559 ZNF689 ZNF267 ZNF69 ZNF700 ZNF441 ZNF563 ZNF557	2.36e-06	679	63	12	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF627 ZNF555 ZNF530 ZNF670 ZNF559 ZNF689 ZNF267 ZNF69 ZNF700 ZNF441 ZNF563 ZNF557	2.95e-06	694	63	12	IPR013087
Domain	Teashirt_fam	TSHZ3 TSHZ2	3.35e-05	3	63	2	IPR027008
Domain	UIM	ATXN3L ANKIB1 HUWE1	7.04e-05	24	63	3	PS50330
Domain	UIM_dom	ATXN3L ANKIB1 HUWE1	7.98e-05	25	63	3	IPR003903
Domain	zf-C2H2_6	ZNF627 ZNF555 ZNF530 ZNF670 ZNF267 ZNF69 ZNF700	8.77e-05	314	63	7	PF13912
Domain	UIM	ATXN3L ANKIB1	1.65e-03	18	63	2	PF02809
Domain	UIM	ATXN3L ANKIB1	2.26e-03	21	63	2	SM00726
Domain	zf-CCHC	RBM4B RBM4	2.71e-03	23	63	2	PF00098
Domain	PAS	PASK HIF1A	3.20e-03	25	63	2	PF00989
Domain	PAS_fold	PASK HIF1A	3.20e-03	25	63	2	IPR013767
Domain	-	RBM4B RBM4	3.45e-03	26	63	2	4.10.60.10
Domain	PAS	PASK HIF1A	5.20e-03	32	63	2	SM00091
Domain	PAS	PASK HIF1A	5.86e-03	34	63	2	IPR000014
Domain	PAS	PASK HIF1A	5.86e-03	34	63	2	PS50112
Domain	ZF_CCHC	RBM4B RBM4	6.20e-03	35	63	2	PS50158
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF627 ZNF555 ZNF670 ZNF689 ZNF267 ZNF441 ZNF563	4.45e-08	181	64	7	37372979
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	THAP4 FUT10 HIF1A SHROOM3 TSHZ2 RBM4 PPFIA2 PRKAA2 AIG1 ANKIB1 RIMS1 HUWE1 ZSWIM4 DENND2B AGAP3	6.12e-08	1489	64	15	28611215
Pubmed	MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1α.	SOX4 HIF1A	3.33e-06	2	64	2	23389731
Pubmed	Phylogenetic and molecular characterization of the splicing factor RBM4.	RBM4B RBM4	3.33e-06	2	64	2	23527094
Pubmed	Chronic Intermittent Hypoxia Impairs Insulin Sensitivity but Improves Whole-Body Glucose Tolerance by Activating Skeletal Muscle AMPK.	HIF1A PRKAA2	3.33e-06	2	64	2	28882901
Pubmed	The LARK/RBM4a protein is highly expressed in cerebellum as compared to cerebrum.	RBM4B RBM4	3.33e-06	2	64	2	18708123
Pubmed	The potential role of Brachyury in inducing epithelial-to-mesenchymal transition (EMT) and HIF-1α expression in breast cancer cells.	HIF1A TBXT	3.33e-06	2	64	2	26393908
Pubmed	Rare and frequent promoter methylation, respectively, of TSHZ2 and 3 genes that are both downregulated in expression in breast and prostate cancers.	TSHZ3 TSHZ2	3.33e-06	2	64	2	21423795
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SOX4 HSPG2 SHROOM3 SZT2 CDK12 SEC16A PCNX1 HUWE1 SPEN ITGB4 AGAP3	5.04e-06	1105	64	11	35748872
Pubmed	Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle.	SYNE2 EMD	9.99e-06	3	64	2	15671068
Pubmed	SRSF1 and RBM4 differentially modulate the oncogenic effect of HIF-1α in lung cancer cells through alternative splicing mechanism.	HIF1A RBM4	9.99e-06	3	64	2	31491447
Pubmed	Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2.	BRCA2 TBXT	9.99e-06	3	64	2	9126738
Pubmed	HIF-1α overexpression in ductal carcinoma in situ of the breast in BRCA1 and BRCA2 mutation carriers.	HIF1A BRCA2	9.99e-06	3	64	2	23409121
Pubmed	BRCA2, ATM, and CDK12 Defects Differentially Shape Prostate Tumor Driver Genomics and Clinical Aggression.	BRCA2 CDK12	9.99e-06	3	64	2	33414135
Pubmed	Direct interaction between the intracellular domains of bullous pemphigoid antigen 2 (BP180) and beta 4 integrin, hemidesmosomal components of basal keratinocytes.	COL17A1 ITGB4	9.99e-06	3	64	2	9500991
Pubmed	RBM4 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Modulating Alternative Splicing of Pyruvate Kinase M.	RBM4B RBM4	9.99e-06	3	64	2	27821480
Pubmed	Teashirt 3 expression in the chick embryo reveals a remarkable association with tendon development.	TSHZ3 TSHZ2	9.99e-06	3	64	2	16631416
Pubmed	Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction.	TSHZ3 TSHZ2	9.99e-06	3	64	2	19745106
Pubmed	5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments.	HIF1A PRKAA2	9.99e-06	3	64	2	16809770
Pubmed	Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.	SYNE2 EMD	9.99e-06	3	64	2	17462627
Pubmed	Three putative murine Teashirt orthologues specify trunk structures in Drosophila in the same way as the Drosophila teashirt gene.	TSHZ3 TSHZ2	9.99e-06	3	64	2	14973285
Pubmed	A novel splicing regulator shares a nuclear import pathway with SR proteins.	RBM4B RBM4	9.99e-06	3	64	2	12628928
Pubmed	Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180.	COL17A1 ITGB4	2.00e-05	4	64	2	9660880
Pubmed	VEGF, HIF-1α expression and MVD as an angiogenic network in familial breast cancer.	HIF1A BRCA2	2.00e-05	4	64	2	23326384
Pubmed	Transmembrane collagen XVII modulates integrin dependent keratinocyte migration via PI3K/Rac1 signaling.	COL17A1 ITGB4	2.00e-05	4	64	2	24505282
Pubmed	Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes.	COL17A1 ITGB4	2.00e-05	4	64	2	14668477
Pubmed	AMP-activated protein kinase suppresses matrix metalloproteinase-9 expression in mouse embryonic fibroblasts.	HIF1A PRKAA2	2.00e-05	4	64	2	21402702
Pubmed	Thalamocortical control of cell-type specificity drives circuits for processing whisker-related information in mouse barrel cortex.	SLC6A4 RIMS1	3.32e-05	5	64	2	37770450
Pubmed	Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes.	SYNE2 EMD	3.32e-05	5	64	2	19933576
Pubmed	RIM1/2 in retinal ganglion cells are required for the refinement of ipsilateral axons and eye-specific segregation.	SLC6A4 RIMS1	3.32e-05	5	64	2	28607399
Pubmed	Neurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortex.	SLC6A4 RIMS1	3.32e-05	5	64	2	22553025
Pubmed	Endorepellin affects angiogenesis by antagonizing diverse vascular endothelial growth factor receptor 2 (VEGFR2)-evoked signaling pathways: transcriptional repression of hypoxia-inducible factor 1α and VEGFA and concurrent inhibition of nuclear factor of activated T cell 1 (NFAT1) activation.	HSPG2 HIF1A	3.32e-05	5	64	2	23060442
Pubmed	HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth.	HIF1A PRKAA2	3.32e-05	5	64	2	25683712
Pubmed	Disruption of the talin gene arrests mouse development at the gastrulation stage.	HSPG2 TBXT	3.32e-05	5	64	2	11084655
Pubmed	Structure and function of hemidesmosomes: more than simple adhesion complexes.	COL17A1 ITGB4	3.32e-05	5	64	2	10201522
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	LENG8 ANK2 CDK12 RBM4B STARD9 SEC16A DOCK7 NKTR EMD RSRC2 LRRFIP2	3.74e-05	1371	64	11	36244648
Pubmed	A Y2H-seq approach defines the human protein methyltransferase interactome.	LENG8 ZNF670 RBM4B DOCK7 SOCS6 ZNF557	4.01e-05	342	64	6	23455924
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	SZT2 DOCK7 RIMS1 RSRC2 SPEN	4.17e-05	208	64	5	33230847
Pubmed	Nbeal2 interacts with Dock7, Sec16a, and Vac14.	SEC16A DOCK7	4.98e-05	6	64	2	29187380
Pubmed	Samp1 is a component of TAN lines and is required for nuclear movement.	SYNE2 EMD	4.98e-05	6	64	2	22349700
Pubmed	Junctional Epidermolysis Bullosa	COL17A1 ITGB4	4.98e-05	6	64	2	20301304
Pubmed	A novel pVHL-independent but NEMO-driven pathway in renal cancer promotes HIF stabilization.	HIF1A CHUK	4.98e-05	6	64	2	26500060
Pubmed	Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.	BRCA2 TBXT	4.98e-05	6	64	2	9171368
Pubmed	Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in the cardiomyocyte sarcomere.	SYNE2 EMD	4.98e-05	6	64	2	38569934
Pubmed	RBM4 promotes neuronal differentiation and neurite outgrowth by modulating Numb isoform expression.	RBM4B RBM4	4.98e-05	6	64	2	27009199
Pubmed	Human transcription factor protein interaction networks.	SOX4 LENG8 HSPG2 TSHZ3 NOL4L RBM4 SYNE2 SEC16A TBXT EMD SPEN	5.44e-05	1429	64	11	35140242
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	PASK CDK12 SYNE2 SEC16A PCNX1	6.06e-05	225	64	5	12168954
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SHROOM3 ANK2 SYNE2 SEC16A DOCK7 RIMS1 HUWE1 LRRFIP2 WDR47	6.48e-05	963	64	9	28671696
Pubmed	FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4.	TSHZ3 TSHZ2	6.96e-05	7	64	2	19343227
Pubmed	LARK activates posttranscriptional expression of an essential mammalian clock protein, PERIOD1.	RBM4B RBM4	6.96e-05	7	64	2	17264215
Pubmed	The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome.	COL17A1 ITGB4	6.96e-05	7	64	2	10637308
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	SHROOM3 EFCAB6 SEC16A DOCK7 EMD HUWE1 SPEN AGAP3	8.79e-05	777	64	8	35844135
Pubmed	An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular development.	HIF1A TBXT	9.27e-05	8	64	2	18710940
Pubmed	K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression.	HIF1A HUWE1	9.27e-05	8	64	2	27934968
Pubmed	Expression patterns of the three Teashirt-related genes define specific boundaries in the developing and postnatal mouse forebrain.	TSHZ3 TSHZ2	9.27e-05	8	64	2	15834955
Pubmed	SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair.	SOX4 ITGB4	1.19e-04	9	64	2	31492871
Pubmed	Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese.	HSPG2 COL17A1	1.19e-04	9	64	2	15081423
Pubmed	Activation of TrkB signaling mitigates cerebellar anomalies caused by Rbm4-Bdnf deficiency.	RBM4B RBM4	1.19e-04	9	64	2	37670183
Pubmed	HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.	HIF1A TBXT	1.19e-04	9	64	2	16510872
Pubmed	Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.	COL17A1 ITGB4	1.19e-04	9	64	2	12482924
Pubmed	Brca2 is required for embryonic cellular proliferation in the mouse.	BRCA2 TBXT	1.19e-04	9	64	2	9171369
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TSHZ3 NOL4L BRCA2 SEC16A DOCK7 HUWE1	1.21e-04	418	64	6	34709266
Pubmed	Ring Finger Protein 11 acts on ligand-activated EGFR via the direct interaction with the UIM region of ANKRD13 protein family.	SHROOM3 HUWE1 CHUK	1.46e-04	55	64	3	31985874
Pubmed	Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling.	HIF1A PRKAA2	1.49e-04	10	64	2	28847007
Pubmed	Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle.	SYNE2 EMD	1.49e-04	10	64	2	28533284
Pubmed	Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice.	BRCA2 TBXT	1.49e-04	10	64	2	20484223
Pubmed	HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα.	HUWE1 CHUK	1.49e-04	10	64	2	30217973
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SHROOM3 STARD9 SYNE2 PRKAA2 SEC16A DOCK7 DENND2B AGAP3	1.78e-04	861	64	8	36931259
Pubmed	Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival.	COL17A1 ITGB4	1.81e-04	11	64	2	8707838
Pubmed	Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis.	COL17A1 ITGB4	1.81e-04	11	64	2	35941116
Pubmed	Basement membrane remodelling regulates mouse embryogenesis.	HSPG2 TBXT	1.81e-04	11	64	2	32523119
Pubmed	Molecular and functional architecture of striatal dopamine release sites.	PPFIA2 RIMS1	1.81e-04	11	64	2	34767769
Pubmed	The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes.	COL17A1 ITGB4	1.81e-04	11	64	2	10811835
Pubmed	Loss of nidogen-1 and -2 results in syndactyly and changes in limb development.	HSPG2 ITGB4	1.81e-04	11	64	2	17023412
Pubmed	Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.	COL17A1 ITGB4	1.81e-04	11	64	2	12802069
Pubmed	Current insights into the formation and breakdown of hemidesmosomes.	COL17A1 ITGB4	1.81e-04	11	64	2	16757171
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	BRCA2 RBM4B RBM4 HDX	1.82e-04	152	64	4	38360978
Pubmed	RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development.	RBM4B RBM4	2.17e-04	12	64	2	29581187
Pubmed	Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice.	HSPG2 TBXT	2.17e-04	12	64	2	22072575
Pubmed	p63 Transcription Factor Regulates Nuclear Shape and Expression of Nuclear Envelope-Associated Genes in Epidermal Keratinocytes.	SYNE2 ITGB4	2.17e-04	12	64	2	28595999
Pubmed	Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse.	HSPG2 ITGB4	2.17e-04	12	64	2	10433923
Pubmed	A glycolytic shift in Schwann cells supports injured axons.	HIF1A PRKAA2	2.17e-04	12	64	2	32807950
Pubmed	A census of human transcription factors: function, expression and evolution.	SOX4 THAP4 TSHZ3 HIF1A TSHZ2 HDX ZNF267 TBXT	2.54e-04	908	64	8	19274049
Pubmed	Basement membranes in skin are differently affected by lack of nidogen 1 and 2.	HSPG2 ITGB4	2.57e-04	13	64	2	18356808
Pubmed	Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain.	COL17A1 ITGB4	2.57e-04	13	64	2	9670011
Pubmed	The protein interaction landscape of the human CMGC kinase group.	PASK NOL4L CDK12 ZNF267 HUWE1 RSRC2 CHUK	2.86e-04	695	64	7	23602568
Pubmed	PRC1 preserves epidermal tissue integrity independently of PRC2.	COL17A1 ITGB4	2.99e-04	14	64	2	30567998
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	CDK12 SEC16A HUWE1 SPEN ITGB4 AGAP3	3.28e-04	503	64	6	16964243
Pubmed	A molecular mechanism underlying the neural-specific defect in torsinA mutant mice.	SYNE2 EMD	3.45e-04	15	64	2	20457914
Pubmed	The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism.	HIF1A PRKAA2	3.45e-04	15	64	2	20399150
Pubmed	The non-canonical Wnt-PCP pathway shapes the mouse caudal neural plate.	SHROOM3 TBXT	3.45e-04	15	64	2	29636380
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	SHROOM3 RBM4 SEC16A EMD	3.46e-04	180	64	4	35198878
Pubmed	The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability.	HIF1A SEC16A DOCK7 EMD LRRFIP2	3.50e-04	328	64	5	23398456
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	ZNF670 STARD9 RBM4 EMD ITGB4 CHUK	3.64e-04	513	64	6	25798074
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	LENG8 SHROOM3 CDK12 RBM4 EMD RSRC2 SPEN	3.87e-04	731	64	7	29298432
Pubmed	ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.	HIF1A SEC16A SOCS6 EMD ZSWIM4	3.91e-04	336	64	5	31253590
Pubmed	Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation.	HSPG2 ITGB4	3.93e-04	16	64	2	21067603
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PASK SHROOM3 SZT2 CDK12 ANKIB1 PCNX1	4.28e-04	529	64	6	14621295
Pubmed	MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters.	COL17A1 ITGB4	4.45e-04	17	64	2	37479688
Pubmed	RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis.	RBM4 HUWE1	4.45e-04	17	64	2	37080995
Cytoband	19p13.2	ZNF627 ZNF559 ZNF69 ZNF700 ZNF441 ZNF563 ZNF557	3.82e-08	229	65	7	19p13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	ZNF627 ZNF555 ZNF559 ZNF69 ZSWIM4 ZNF700 ZNF441 ZNF563 ZNF557	1.84e-06	797	65	9	chr19p13
Cytoband	14q23.2	HIF1A SYNE2	3.69e-04	20	65	2	14q23.2
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF627 TSHZ3 ZNF555 ZNF530 ZNF670 TSHZ2 ZNF559 ZNF689 ZNF267 ZNF69 ZNF700 ZNF441 ZNF563 ZNF557	2.16e-09	718	47	14	28
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	TSHZ3 TSHZ2	6.80e-04	15	47	2	529
GeneFamily	Zinc fingers CCHC-type\|RNA binding motif containing	RBM4B RBM4	1.91e-03	25	47	2	74
Coexpression	FAN_OVARY_CL3_MATURE_CUMULUS_GRANULOSA_CELL_1	SOX4 HSPG2 HIF1A TSHZ2 SYNE2 NKTR HUWE1	2.87e-06	254	64	7	M41705
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HNBML5	SOX4 ANK2 TSHZ2 PPFIA2 ANKIB1 RIMS1 SRRM3 ZNF441	1.71e-05	465	64	8	M39066
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SOX4 LENG8 TSHZ2 PRKAA2 NKTR RIMS1	2.48e-07	179	65	6	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	IPF-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	HSPG2 HIF1A TSHZ2 SYNE2 ZNF267 LRRC8B	4.48e-07	198	65	6	b8bd1ba268480f54451648e01631b615a3401144
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma\|TCGA-Brain / Sample_Type by Project: Shred V9	DPY19L3 SZT2 DOCK7 SPEN ITGB4	3.95e-06	162	65	5	810881210e015c788814e4fe8d7a24c929cf2621
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	SYNE2 PCNX1 NKTR HUWE1 SPEN	8.14e-06	188	65	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	3'-Broncho-tracheal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SOX4 COL17A1 TSHZ2 SYNE2 ITGB4	1.02e-05	197	65	5	5d33f8a6940431093e927b186fb9b630a89d8ec1
ToppCell	control\|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SOX4 TSHZ2 SYNE2 ITGB4 DENND2B	1.10e-05	200	65	5	97f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-Proliferative_Immature_MyoFibroblast\|E16.5-samps / Age Group, Lineage, Cell class and subclass	TEKT3 PASK RIMS1 SRRM3	4.55e-05	135	65	4	ed0f94d3839eea3b60217c4352159ed481361f13
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4-Tnaive/CM_CD4_activated\|Lung / Manually curated celltypes from each tissue	ZNF627 TSHZ2 STARD9 LRRC8B	7.04e-05	151	65	4	9bfb807e1180b31fa9a2c500ce993de9707c070f
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-Tnaive/CM_CD4\|Lung / Manually curated celltypes from each tissue	TEKT3 PASK EFCAB6 TSHZ2	9.24e-05	162	65	4	91cc14aec8d580cf97a1929bc1acb00fcbcdb57a
ToppCell	Healthy_Control-Lymphoid-Plasma\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	PASK TSHZ2 RBM4B ZSWIM4	9.46e-05	163	65	4	2913ccdd4613472cd82077d4993e1d9f8b223398
ToppCell	Healthy_Control-Lymphoid-Plasma-\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	PASK TSHZ2 RBM4B ZSWIM4	9.46e-05	163	65	4	b589ff57d58dcb215ee3b5a10d81f43e5752a196
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TEKT3 NOL4L COL17A1 SYNE2	9.69e-05	164	65	4	ed7277f8980f96f5b3e4eed025d46d0942e123d7
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TEKT3 NOL4L COL17A1 SYNE2	9.69e-05	164	65	4	c4ad98106e8663caf7c1c15d30ec633d8bd8cf57
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|356C / Donor, Lineage, Cell class and subclass (all cells)	STARD9 SYNE2 PCNX1 ZNF557	1.02e-04	166	65	4	c4f7ea1cad962b1d6ad77423d15978b68a0d6f1d
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PASK SYNE2 PCNX1 NKTR	1.04e-04	167	65	4	83969c36ac44b96afc9aa09400a99fa2b487f7ff
ToppCell	NS-critical-d_0-4-Epithelial-Secretory\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	HSPG2 PRKAA2 AIG1 ITGB4	1.09e-04	169	65	4	aec97583b23112060437b619cb429dc32f29285f
ToppCell	normal-na-Lymphocytic_B-B_plasma-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	TEKT3 HSPG2 FUT10 BRCA2	1.11e-04	170	65	4	c5b87974dfddf9780051f7f5693eeeb0c606a3fe
ToppCell	Club_cells-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	SOX4 SYNE2 RIMS1 ITGB4	1.27e-04	176	65	4	88c4ed0ab4a4ede8cad21385d799b723b5786cd9
ToppCell	ASK428-Epithelial-Secretory\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	TSHZ3 COL17A1 RBM4B ITGB4	1.30e-04	177	65	4	66074a288501c136b4e83b883db5f0d8269ee326
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	TSHZ2 SYNE2 NKTR HUWE1	1.42e-04	181	65	4	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PASK NOL4L TSHZ2 SYNE2	1.45e-04	182	65	4	9ba85f621a846531a2a7861e9df695d288c9e149
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	NOL4L TSHZ2 SYNE2 NKTR	1.48e-04	183	65	4	f2ef110bf29b1a8276ef216238363e542db262c1
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NOL4L TSHZ2 SYNE2 NKTR	1.51e-04	184	65	4	5350b58aa9979631228835d11eb45ddf81d08bff
ToppCell	Control-Epithelial_cells-Airway_goblet\|Control / group, cell type (main and fine annotations)	COL17A1 TSHZ2 RIMS1 ITGB4	1.51e-04	184	65	4	d92a71441e4e19f8c301999d8186f8e48e3cd162
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TSHZ2 SYNE2 PCNX1 NKTR	1.51e-04	184	65	4	bd786db4dc4edae6d5cfc0b69901983dea19f729
ToppCell	ILEUM-inflamed-(8)_Fibroblast-(8)_Smooth_muscle_cells\|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SOX4 TSHZ3 TSHZ2 RIMS1	1.57e-04	186	65	4	cacc2f0b2ed46516173b61ba1c5c226a2db7cddc
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZNF555 TSHZ2 RIMS1 ZNF563	1.60e-04	187	65	4	f5a202d5f8eb57b57d80815ce98774e04c387383
ToppCell	(1)_T_CD4_naive\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	PASK TSHZ2 SYNE2 NKTR	1.64e-04	188	65	4	b8f67ac2faadd5b848955e43ab5d6cf5e49b3681
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SOX4 COL17A1 RIMS1 SRRM3	1.64e-04	188	65	4	e239bcdbd210a398a5850cb6fbf171d402f45a4f
ToppCell	COVID-19-Epithelial-Ionocytes\|COVID-19 / Condition, Lineage and Cell class	HSPG2 ANK2 PRKAA2 ITGB4	1.64e-04	188	65	4	a581cb9528d0febbf3addbb4f6bc140f91a584e6
ToppCell	droplet-Tongue-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX4 CDK12 SYNE2 RSRC2	1.64e-04	188	65	4	d62cc37e86b7b186e53aeb7f421c4e5ee28f23bd
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	LENG8 NOL4L SYNE2 NKTR	1.67e-04	189	65	4	0e8d1be3c406d1a393e18faccfe89116a8f82bcf
ToppCell	COVID-19-lung-Secretory\|lung / Disease (COVID-19 only), tissue and cell type	SHROOM3 COL17A1 RIMS1 ITGB4	1.67e-04	189	65	4	84d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|RV / Chamber and Cluster_Paper	ANK2 PRKAA2 AIG1 LRRFIP2	1.67e-04	189	65	4	9c1debd65c13d63fd4f3158917d621b44b714c26
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	TSHZ2 SYNE2 PCNX1 NKTR	1.78e-04	192	65	4	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	Club_cells\|World / lung cells shred on cell class, cell subclass, sample id	SOX4 SYNE2 PRKAA2 RIMS1	1.81e-04	193	65	4	9d3165dc5763a07a7d873f497624d9d6528fa2db
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANK2 LRRC8B SOCS6 SRRM3	1.81e-04	193	65	4	a189d46c39067b717509cd144e0225cc93d7731d
ToppCell	PCW_07-8.5\|World / Celltypes from embryonic and fetal-stage human lung	BRCA2 PPFIA2 ZNF69 RIMS1	1.85e-04	194	65	4	5759c83308df017f1faae248e9b85388e25254f0
ToppCell	severe_COVID-19-CD4+_T_naive\|severe_COVID-19 / disease group, cell group and cell class (v2)	PASK TSHZ2 SYNE2 NKTR	1.85e-04	194	65	4	4b86f3cc173ea779399d5b3598b45b25f60a4395
ToppCell	droplet-Bladder-nan-3m-Epithelial-basal_bladder_epithelial_cell_(Krt5+Krt14+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIF1A COL17A1 PRKAA2 ITGB4	1.85e-04	194	65	4	37803f4abf1aa1ad771c9cd293933003d7101e70
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK2 SEC16A NKTR HUWE1	1.85e-04	194	65	4	0b023de48ed8a550d169bbe954881eb04bf4f981
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PASK TSHZ2 SYNE2 PCNX1	1.85e-04	194	65	4	a44be2f021cfdd0fcdc698c3f04d66db7a1aa6c2
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-T_lymphocytic-effector_CD4-positive,_alpha-beta_T_cell\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PASK TSHZ2 SYNE2 PCNX1	1.88e-04	195	65	4	e4caa01d2040a6f4dd90e68c2e1e99c5405e2eba
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	TSHZ3 TSHZ2 RIMS1 LRRFIP2	1.88e-04	195	65	4	c5d2d9f12fd893331c9de261af30607d845d4f6a
ToppCell	critical-Epithelial-Secretory\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SOX4 TSHZ2 PRKAA2 RIMS1	1.92e-04	196	65	4	7da687eb983a54c28ee990424cc52e01caf5f4aa
ToppCell	COVID-19-Epithelial-Club,_Basal_cells\|COVID-19 / Condition, Lineage and Cell class	TSHZ2 PRKAA2 RIMS1 ITGB4	1.92e-04	196	65	4	dd32046067d93b9484cfbf1d7826a436a3d9f0e9
ToppCell	Basal_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	SOX4 COL17A1 SYNE2 ITGB4	1.92e-04	196	65	4	3b66f3a79b3f2ebacb4ad646f179e505ab38d6f0
ToppCell	Sepsis-URO-Lymphocyte-T/NK-Treg\|URO / Disease, condition lineage and cell class	PASK TSHZ2 SYNE2 ZNF563	1.92e-04	196	65	4	8812d7365fb2b33feff93782d60776e932499a43
ToppCell	COPD-Epithelial-Club\|Epithelial / Disease state, Lineage and Cell class	SOX4 RIMS1 ZSWIM4 LRRFIP2	1.92e-04	196	65	4	af96fb94886e9395f3e2cd0a293af29229d017fe
ToppCell	P07-Mesenchymal-myocytic_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SOX4 ANK2 TSHZ2 AIG1	1.96e-04	197	65	4	378299fe2ec6ed2fc858febb78ff1ac0898e457d
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TSHZ3 COL17A1 TSHZ2 ITGB4	1.96e-04	197	65	4	1e915957ea6a4550ecb9d6ee4b232aa5800faf20
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX4 SHROOM3 COL17A1 ITGB4	1.96e-04	197	65	4	f4dad4423384a2a25e064c849ffccf2811573be0
ToppCell	P07-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SOX4 ANK2 TSHZ2 AIG1	1.96e-04	197	65	4	b1135378d768fbbe62a75747d1e8653d35252187
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TSHZ2 STARD9 SYNE2 NKTR	1.96e-04	197	65	4	e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell	NS-critical-d_16-33-Epithelial-Secretory\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SOX4 TSHZ2 PRKAA2 RIMS1	1.96e-04	197	65	4	a72047b7428c0d4aaf016c1ac23dc30919260fd8
ToppCell	Control-PLT_4\|Control / Disease Group and Platelet Clusters	THAP4 ZNF267 LRRC8B RSRC2	2.00e-04	198	65	4	387fd3037fd52e4d4c42de0588767e58af228b59
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD4-positive_helper_T_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PASK TSHZ2 SYNE2 PCNX1	2.00e-04	198	65	4	c4d8d133e571ad3a7c5de93aa7befb67cb7a003d
ToppCell	Bronchial_Biopsy\|World / Tissue, Lineage and Cell class of Lung Cells from 10X	COL17A1 TSHZ2 SYNE2 ITGB4	2.00e-04	198	65	4	f5b7013045b61fc56894f80092f799770dde1c8f
ToppCell	3'-Broncho-tracheal-Epithelial\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SOX4 COL17A1 TSHZ2 ITGB4	2.00e-04	198	65	4	aa6e7218ee6230902854e66c444b544218b30c0e
ToppCell	NS-control-d_0-4-Epithelial-Secretory\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TSHZ2 PRKAA2 NKTR RIMS1	2.04e-04	199	65	4	32bdfff40fd442b88489c8b0f79af3927a51a03c
ToppCell	Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	SOX4 HSPG2 ANK2 DENND2B	2.04e-04	199	65	4	40de6d4a31cf22efa2864f79e4ec8e2b7bfc9d4a
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SOX4 COL17A1 TSHZ2 ITGB4	2.04e-04	199	65	4	c88a28a73f54dc571f2ff1e4b55073f83cbead2c
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	SOX4 ANK2 PPFIA2 SRRM3	2.04e-04	199	65	4	5de2a32bc2e9c752eb19a013b1807949153728fc
ToppCell	control-Epithelial-Secretory\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	TSHZ2 PRKAA2 NKTR RIMS1	2.04e-04	199	65	4	262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal-Suprabasal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TSHZ3 TSHZ2 RIMS1 ITGB4	2.04e-04	199	65	4	f5c3561744e2a0e7716657cb521acb1d8f054b41
ToppCell	proximal-Epithelial-Proximal_Basal-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL17A1 TSHZ2 PRKAA2 ITGB4	2.08e-04	200	65	4	de9aec87c86ad0a1bd5e0737c2aae0ec6f269bca
ToppCell	Sepsis-URO-Lymphocyte-T/NK-dn_T\|URO / Disease, condition lineage and cell class	THAP4 SYNE2 AIG1 ZNF563	2.08e-04	200	65	4	04ea6381b93a5d8bbeda4d71c788d7fbac6d40bc
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TSHZ3 COL17A1 TSHZ2 ITGB4	2.08e-04	200	65	4	8827653738a931e4a4545e0c7d75be12bed40740
ToppCell	Biopsy_IPF-Epithelial-KRT5-/KRT17+\|Biopsy_IPF / Sample group, Lineage and Cell type	SOX4 HSPG2 COL17A1 ZSWIM4	2.08e-04	200	65	4	2fc7a3b3aea711ad3d96fd9513f4b40533056d86
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Neuronal-Cortical_neuron\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	SOX4 ANK2 PPFIA2 AGAP3	2.08e-04	200	65	4	5b3df61ff421846ef4cabf1bd5355534c8b95509
ToppCell	proximal-3-Epithelial-Proximal_Basal\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL17A1 TSHZ2 PRKAA2 ITGB4	2.08e-04	200	65	4	3a0c84f9a551fc2581ec3693481eada297d83f7b
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Cortical_neuron\|10w / Sample Type, Dataset, Time_group, and Cell type.	SOX4 ANK2 PPFIA2 SRRM3	2.08e-04	200	65	4	68c90376e2779434e4ad8dc6dd3b44baa700e2f4
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuronal\|10w / Sample Type, Dataset, Time_group, and Cell type.	SOX4 ANK2 PPFIA2 SRRM3	2.08e-04	200	65	4	979258173b82f37aeaaedd53b4a527da1dbe1b80
ToppCell	NS-control\|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SOX4 TSHZ2 SYNE2 ITGB4	2.08e-04	200	65	4	ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCell	Sigmoid-T_cell-Activated_CD4_T\|T_cell / Region, Cell class and subclass	PASK TSHZ2 SYNE2 ZSWIM4	2.08e-04	200	65	4	9c21e6b8d4f8e526950adacf9cc45a5e86d81c1f
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Neuronal-Cortical_neuron\|6m / Sample Type, Dataset, Time_group, and Cell type.	ANK2 PPFIA2 SRRM3 WDR47	2.08e-04	200	65	4	6f7ff0533339fcc9d316f2c77334a79c1409ec4f
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Cortical_neuron\|3m / Sample Type, Dataset, Time_group, and Cell type.	SOX4 ANK2 PPFIA2 WDR47	2.08e-04	200	65	4	c248233b004f8ef0bab3c65ecfe295887966f2ee
ToppCell	proximal-Epithelial-Proximal_Basal\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL17A1 TSHZ2 PRKAA2 ITGB4	2.08e-04	200	65	4	ff2afa5c0352c214525129f9ff85afc139fe44d2
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal\|3m / Sample Type, Dataset, Time_group, and Cell type.	SOX4 ANK2 PPFIA2 WDR47	2.08e-04	200	65	4	af99d90070e2933fd2e9512590c6cf3bd6e15539
Disease	Autosomal Recessive Emery-Dreifuss Muscular Dystrophy	SYNE2 EMD	4.47e-05	5	63	2	C1450051
Disease	Adult junctional epidermolysis bullosa (disorder)	COL17A1 ITGB4	4.47e-05	5	63	2	C0268374
Disease	EPIDERMOLYSIS BULLOSA, JUNCTIONAL, LOCALISATA VARIANT (disorder)	COL17A1 ITGB4	4.47e-05	5	63	2	C2608084
Disease	Autosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)	SYNE2 EMD	4.47e-05	5	63	2	C0410190
Disease	junctional epidermolysis bullosa non-Herlitz type (implicated_via_orthology)	COL17A1 ITGB4	4.47e-05	5	63	2	DOID:0060738 (implicated_via_orthology)
Disease	Emery-Dreifuss muscular dystrophy	SYNE2 EMD	6.69e-05	6	63	2	cv:C0410189
Disease	Junctional Epidermolysis Bullosa	COL17A1 ITGB4	6.69e-05	6	63	2	C0079301
Disease	Muscular Dystrophy, Emery-Dreifuss	SYNE2 EMD	6.69e-05	6	63	2	C0410189
Disease	junctional epidermolysis bullosa (is_implicated_in)	COL17A1 ITGB4	9.36e-05	7	63	2	DOID:3209 (is_implicated_in)
Disease	X-Linked Emery-Dreifuss Muscular Dystrophy	SYNE2 EMD	9.36e-05	7	63	2	C0751337
Disease	triglyceride measurement, intermediate density lipoprotein measurement	SHROOM3 BRCA2 SYNE2 DOCK7	9.52e-05	111	63	4	EFO_0004530, EFO_0008595
Disease	very low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio	SLC6A4 SHROOM3 SYNE2 SEC16A DOCK7	1.14e-04	222	63	5	EFO_0008317, EFO_0020943
Disease	Salivary Gland Neoplasms	SOX4 SPEN ITGB4	1.41e-04	47	63	3	C0036095
Disease	Amelogenesis Imperfecta	COL17A1 ITGB4	2.92e-04	12	63	2	C0002452
Disease	triglycerides:total lipids ratio, low density lipoprotein cholesterol measurement	SLC6A4 SHROOM3 SYNE2 DOCK7	3.03e-04	150	63	4	EFO_0004611, EFO_0020947
Disease	Manic Disorder	SLC6A4 STARD9 RIMS1	4.78e-04	71	63	3	C0024713
Disease	Manic	SLC6A4 STARD9 RIMS1	6.30e-04	78	63	3	C0338831
Disease	Depression, Bipolar	SLC6A4 STARD9 RIMS1	6.53e-04	79	63	3	C0005587
Disease	Cardiac Hypertrophy	SOX4 HIF1A PRKAA2	7.28e-04	82	63	3	C1383860
Disease	Cardiomegaly	SOX4 HIF1A PRKAA2	7.28e-04	82	63	3	C0018800
Disease	low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	SLC6A4 SHROOM3 SYNE2 DOCK7	8.93e-04	200	63	4	EFO_0004611, EFO_0020945
Disease	Neoplasm of uncertain or unknown behavior of ovary	BRCA2 CDK12	1.76e-03	29	63	2	C0496920
Disease	longevity, healthspan, parental longevity	SLC6A4 NOL4L	1.76e-03	29	63	2	EFO_0004300, EFO_0007796, EFO_0009762
Disease	Ovarian Carcinoma	BRCA2 CDK12	1.88e-03	30	63	2	C0029925
Disease	Neural Tube Defects	SHROOM3 TBXT	1.88e-03	30	63	2	C0027794
Disease	prostate cancer (is_implicated_in)	HIF1A BRCA2 CHUK	2.03e-03	117	63	3	DOID:10283 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SHRSPSERRSHRSFE	C2orf16	1821	Q68DN1
HSASSASLHSERPLS	AGAP3	466	Q96P47
TRGHASTSSYRRAHS	COL17A1	71	Q9UMD9
STSSYRRAHSPASTL	COL17A1	76	Q9UMD9
RSRSPAYSRHSSSHS	CDK12	356	Q9NYV4
RTSHHQYPSRSSGLT	AIG1	146	Q9NVV5
HRPRSSFDSTTAESH	PRKAA2	496	P54646
SVLHSSSLRDYTPAS	ANKIB1	821	Q9P2G1
RTLTNHPHYEDSSLR	DPY19L3	591	Q6ZPD9
ETSACRYPSHSSSRV	DENND2B	51	P78524
ASHLTSTSLDPYDRH	RBM4	261	Q9BWF3
SSAYTRHLISTHFAP	HSPG2	1336	P98160
RSHTLSHASYLRDSA	ANK2	906	Q01484
EPSRSFSSAHRHLSR	PASK	36	Q96RG2
YHLTPRTSLHTASST	HDX	371	Q7Z353
HIHKETTSATSSPYR	HIF1A	646	Q16665
LKHRPSDHSYSDSTE	CHUK	571	O15111
RSPTRHFRRSDSHSD	LENG8	426	Q96PV6
HSSYLHERPTTSSRA	ATXN3L	306	Q9H3M9
SHVSSSTSVRFYPHD	PCNX1	911	Q96RV3
PSASYHSPELHSTRV	LMLN2	766	A0A1B0GTW7
HSRDSAAITHSTYSL	NOL4L	306	Q96MY1
SHLNSTSVDPYDRHL	RBM4B	261	Q9BQ04
QRRSHHAASTTTAPT	HUWE1	1081	Q7Z6Z7
TRSEHSHSTTLPRDY	ITGB4	1496	P16144
HYPSTSSRLEHFVAI	LRRC8B	141	Q6P9F7
DRSSRLSSLNHSYSH	LRRFIP2	116	Q9Y608
HPARSRSSEHSSIRT	RIMS1	1211	Q86UR5
VHNLLSSHDSDPRYS	DOCK7	1216	Q96N67
IRTEHSLHYSPTSRQ	BRCA2	2086	P51587
THSRPHSSPCRVYSR	EFCAB6	21	Q5THR3
ATFSRHSHLPLTTQY	FUT10	171	Q6P4F1
HYRPVSASRSSLDLS	EMD	166	P50402
GVLTHHRSRLSSRYS	FAM216A	146	Q8WUB2
THTASYRRGIETHTT	FAM27D1	126	Q5T7N8
HTLPSSYHNDARSSL	PPFIA2	786	O75334
PSDFHARHAATSRTY	PUSL1	116	Q8N0Z8
QHHRSTSESSASFPR	SZT2	1636	Q5T011
VSPRASKHHYSRSRS	RSRC2	31	Q7L4I2
HHSLYKARTPSASAS	SOX4	256	Q06945
HSPSLSSHYSDSRSP	SRRM3	261	A6NNA2
SSHYSDSRSPSRLSP	SRRM3	266	A6NNA2
PADYDSLRTLSHHAS	SYNE2	3811	Q8WXH0
RERSSRSSSLSSHHS	NKTR	481	P30414
SPSSRSHSRNKYSDH	NKTR	721	P30414
SDSESDRSYSHHRSP	NKTR	1441	P30414
DRSYSHHRSPSESSR	NKTR	1446	P30414
GHNYRPHRTVSTSST	SHROOM3	806	Q8TF72
SSYRDRFPHSNLTHS	TEKT3	31	Q9BXF9
PVATHAYSSHSSTLL	STARD9	2961	Q9P2P6
QSYHPHSSDVRSVRF	WDR47	836	O94967
AYTSSLRRHERTHSG	ZNF700	316	Q9H0M5
FDYPSSVQRHERTHT	ZNF441	596	Q8N8Z8
SYSSTFRRHTITHTG	ZNF555	266	Q8NEP9
HSPRASALYESSRLS	SPEN	1391	Q96T58
VHPDSVSSSYSSRSH	SEC16A	516	O15027
SYLTTHRRSHSGERP	ZNF267	701	Q14586
SRSSYFRIHERTHTG	ZNF627	401	Q7L945
PSTHSCDRYPTLRSH	TBXT	271	O15178
RTPSTYISHLESHLG	TSHZ2	936	Q9NRE2
RTPSTYISHLESHLG	TSHZ3	986	Q63HK5
ALPDSSSYIRHERTH	ZNF563	261	Q8TA94
FSYPSLLVSHRRAHS	ZNF689	186	Q96CS4
SSSSSFRYHERTHTG	ZNF69	516	Q9UC07
TNLYRHRSAHTSTRP	ZNF530	336	Q6P9A1
HRSAHTSTRPYECSE	ZNF530	341	Q6P9A1
TRSSLSSHYSIHTGE	ZNF557	296	Q8N988
TLHSTSPAEEFYTRH	SLC6A4	221	P31645
TESSYLTQHLRTHSR	ZNF559	251	Q9BR84
PIRSTSLRSHHYSPA	SOCS6	121	O14544
HSYSFSSKHTRERPS	THAP4	236	Q8WY91
FTSSSALRSHERTHT	ZNF670	346	Q9BS34
TAYITTSHSRLTHIS	ZSWIM4	921	Q9H7M6