Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein tyrosine kinase binding

PITPNM1 FCRL3 EIF3A PLCG1 PLCG2 CTNND1

1.10e-041491016GO:1990782
GeneOntologyBiologicalProcesstissue morphogenesis

DLG5 FRAS1 TBX4 KIF26B LAMA5 FLG2 SETDB2 SETD2 CELSR1 DKK1 YAP1 DLG1 MACF1 FLRT3 CTNND1 EXOC4

8.17e-0775010216GO:0048729
GeneOntologyBiologicalProcesskidney development

CFH DLG5 FRAS1 KIF26B LAMA5 REN KANK2 DDC YAP1 DLG1 CTNND1

2.33e-0637210211GO:0001822
GeneOntologyBiologicalProcessrenal system development

CFH DLG5 FRAS1 KIF26B LAMA5 REN KANK2 DDC YAP1 DLG1 CTNND1

3.32e-0638610211GO:0072001
GeneOntologyBiologicalProcessepithelium development

CFH FLG DLG5 FRAS1 TBX4 KIF26B LAMA5 REN FLG2 KANK2 NCOR1 SETDB2 SETD2 CELSR1 DKK1 ZFP36L1 YAP1 KRT20 DLG1 FLRT3 CTNND1

8.49e-06146910221GO:0060429
GeneOntologyBiologicalProcessmorphogenesis of an epithelium

DLG5 FRAS1 TBX4 KIF26B LAMA5 FLG2 SETDB2 SETD2 CELSR1 YAP1 DLG1 FLRT3 CTNND1

1.14e-0561910213GO:0002009
GeneOntologyBiologicalProcessskin development

FLG FRAS1 LAMA5 FLG2 ITGB4 NCOR1 CELSR1 DKK1 ZFP36L1 YAP1

1.61e-0537310210GO:0043588
GeneOntologyBiologicalProcesscell-cell adhesion

CFH DLG5 KIF26B PKP4 PKD1L1 PCDHB12 MARCHF7 ITGB4 SLITRK1 CELSR1 CELSR2 ZFP36L1 DLG1 FLRT3 CTNND1 UBASH3B CX3CR1

2.02e-05107710217GO:0098609
GeneOntologyBiologicalProcessmorphogenesis of a polarized epithelium

DLG5 LAMA5 CELSR1 YAP1 CTNND1

3.08e-05731025GO:0001738
GeneOntologyBiologicalProcessembryonic morphogenesis

FRAS1 TBX4 LAMA5 SETDB2 SETD2 CELSR1 DKK1 ZFP36L1 YAP1 DLG1 MACF1 FLRT3 EXOC4

4.98e-0571310213GO:0048598
GeneOntologyBiologicalProcessmotor neuron migration

RELN CELSR1 CELSR2

5.12e-05151023GO:0097475
GeneOntologyBiologicalProcessmesoderm development

SETD2 DKK1 ZFP36L1 YAP1 MACF1 EXOC4

1.30e-041571026GO:0007498
GeneOntologyBiologicalProcessskin epidermis development

FLG LAMA5 FLG2 NCOR1 CELSR1 DKK1

1.77e-041661026GO:0098773
GeneOntologyBiologicalProcessnephron development

CFH KIF26B LAMA5 YAP1 DLG1 CTNND1

2.28e-041741026GO:0072006
GeneOntologyCellularComponentbasement membrane

FRAS1 LAMA5 FREM3 ITGB4 PXDN DLG1

3.15e-051221036GO:0005604
GeneOntologyCellularComponentkeratohyalin granule

FLG FLG2

2.38e-0451032GO:0036457
GeneOntologyCellularComponentpostsynaptic density

DLG5 PKP4 SLITRK1 DLG1 MACF1 EIF3A FLRT3 CTNND1 EXOC4

3.91e-044511039GO:0014069
GeneOntologyCellularComponentfemale germ cell nucleus

YAP1 RFPL3 RFPL2

4.72e-04311033GO:0001674
GeneOntologyCellularComponentasymmetric synapse

DLG5 PKP4 SLITRK1 DLG1 MACF1 EIF3A FLRT3 CTNND1 EXOC4

5.86e-044771039GO:0032279
GeneOntologyCellularComponentglutamatergic synapse

DLG5 FXR2 PI4K2A LAMA5 ABLIM3 ITGB4 SLITRK1 DLG1 PLAT FLRT3 PLCG1 CTNND1

6.87e-0481710312GO:0098978
GeneOntologyCellularComponentcell leading edge

GBF1 ABLIM3 ITGB4 FRMD4B MACF1 PLCG1 PLCG2 CTNND1 EXOC4

8.19e-045001039GO:0031252
GeneOntologyCellularComponentmyelin sheath abaxonal region

DLG1 EXOC4

8.46e-0491032GO:0035748
GeneOntologyCellularComponentgrowth cone membrane

FLRT3 EXOC4

8.46e-0491032GO:0032584
GeneOntologyCellularComponentpostsynaptic specialization

DLG5 PKP4 SLITRK1 DLG1 MACF1 EIF3A FLRT3 CTNND1 EXOC4

8.54e-045031039GO:0099572
GeneOntologyCellularComponentneuron to neuron synapse

DLG5 PKP4 SLITRK1 DLG1 MACF1 EIF3A FLRT3 CTNND1 EXOC4

1.12e-035231039GO:0098984
GeneOntologyCellularComponentcollagen-containing extracellular matrix

FLG FRAS1 RELN LAMA5 FREM3 ITGB4 PXDN DLG1 PLAT

1.23e-035301039GO:0062023
GeneOntologyCellularComponentpostsynapse

DLG5 FXR2 PKP4 GABRQ ITGB4 SLITRK1 DLG1 MACF1 PLAT EIF3A FLRT3 CTNND1 EXOC4

1.48e-03101810313GO:0098794
GeneOntologyCellularComponentextracellular matrix

FLG FRAS1 RELN LAMA5 FREM3 ITGB4 PXDN DLG1 PLAT FLRT3

1.48e-0365610310GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

FLG FRAS1 RELN LAMA5 FREM3 ITGB4 PXDN DLG1 PLAT FLRT3

1.52e-0365810310GO:0030312
GeneOntologyCellularComponentpostsynaptic density, intracellular component

DLG1 CTNND1 EXOC4

1.82e-03491033GO:0099092
MousePhenoabnormal visceral yolk sac mesenchyme morphology

SETD2 ZFP36L1 YAP1 MTTP PLCG1

1.47e-0636775MP:0020516
MousePhenoabnormal visceral yolk sac blood island morphology

ZFP36L1 YAP1 MTTP PLCG1

2.72e-0532774MP:0011204
MousePhenoabnormal visceral yolk sac morphology

FLI1 TBX4 SETD2 ZFP36L1 YAP1 MTTP PLCG1 EXOC4

4.52e-05236778MP:0001718
MousePhenoincomplete rostral neuropore closure

LAMA5 JARID2 CELSR1 MTTP FLRT3

4.66e-0572775MP:0000928
MousePhenoabnormal rostral neuropore morphology

LAMA5 JARID2 CELSR1 MTTP FLRT3

4.66e-0572775MP:0012543
MousePhenoabnormal embryonic growth/weight/body size

FLI1 DLG5 TBX4 PKD1L1 LAMA5 DDC FANCA JARID2 BPTF NCOR1 SETD2 ZFP36L1 YAP1 MTTP DLG1 FLRT3 PLCG1 AFF4 EXOC4

5.61e-0512957719MP:0002088
MousePhenoabnormal neuropore morphology

LAMA5 JARID2 CELSR1 MTTP FLRT3

6.45e-0577775MP:0012542
MousePhenoabnormal tail morphology

FRAS1 SLC29A3 MTF2 LAMA5 MLLT10 CELSR1 PXDN DLG1 CX3CR1 AFF4

6.94e-054037710MP:0002111
MousePhenoimpaired branching involved in ureteric bud morphogenesis

FRAS1 KIF26B LAMA5 DLG1

7.38e-0541774MP:0004936
MousePhenoretina gliosis

PXDN YAP1 CX3CR1

8.55e-0516773MP:0009392
MousePhenoabnormal embryonic tissue morphology

DLG5 TBX4 LAMA5 MLLT10 DDC JARID2 BPTF SETD2 CELSR1 DKK1 ZFP36L1 YAP1 MTTP DLG1 MACF1 FLRT3 EXOC4

9.55e-0511167717MP:0002085
MousePhenoabnormal branching involved in ureteric bud morphogenesis

FRAS1 KIF26B LAMA5 DLG1

1.07e-0445774MP:0010981
MousePhenoabnormal extracellular matrix morphology

FRAS1 LAMA5 PXDN PLAT FLRT3

2.23e-04100775MP:0013258
MousePhenohemorrhage

CFH FLI1 DLG5 FRAS1 TBX4 MLLT10 FANCA JARID2 MTTP PLAT PLCG2 CX3CR1

2.57e-046647712MP:0001914
MousePhenoabnormal megakaryocyte progenitor cell morphology

FLI1 JARID2 ARHGAP21

2.63e-0423773MP:0002413
MousePhenoabnormal ureteric bud morphology

FRAS1 KIF26B LAMA5 DLG1

2.69e-0457774MP:0006032
MousePhenoabnormal prenatal growth/weight/body size

FLI1 DLG5 TBX4 PKD1L1 LAMA5 DDC FANCA JARID2 BPTF NCOR1 SETD2 ZFP36L1 YAP1 MTTP DLG1 FLRT3 PLCG1 AFF4 EXOC4

3.66e-0414937719MP:0004196
DomainCalx_beta

FRAS1 FREM3 ITGB4

8.18e-0681003SM00237
DomainCalx_beta

FRAS1 FREM3 ITGB4

1.22e-0591003IPR003644
DomainCalx-beta

FRAS1 FREM3 ITGB4

1.22e-0591003PF03160
DomainPLC-gamma

PLCG1 PLCG2

2.84e-0521002IPR016279
DomainFilaggrin

FLG FLG2

2.84e-0521002IPR003303
DomainSH3

DLG5 SNX33 DLG1 MACF1 PLCG1 PLCG2 UBASH3B

1.62e-042161007PS50002
DomainConA-like_dom

TRIM35 LAMA5 ITGB4 CELSR1 CELSR2 RFPL3 RFPL2

1.76e-042191007IPR013320
DomainSH3_domain

DLG5 SNX33 DLG1 MACF1 PLCG1 PLCG2 UBASH3B

1.81e-042201007IPR001452
DomainRDM_domain_RFPL

RFPL3 RFPL2

2.81e-0451002IPR022723
DomainRDM

RFPL3 RFPL2

2.81e-0451002PF11002
DomainEGF_LAM_2

LAMA5 CELSR1 CELSR2

5.44e-04301003PS50027
DomainEGF_LAM_1

LAMA5 CELSR1 CELSR2

5.44e-04301003PS01248
DomainPlakophilin/d_Catenin

PKP4 CTNND1

5.86e-0471002IPR028435
DomainEGF_Lam

LAMA5 CELSR1 CELSR2

8.61e-04351003SM00180
DomainLaminin_EGF

LAMA5 CELSR1 CELSR2

8.61e-04351003PF00053
DomainGPS

PKD1L1 CELSR1 CELSR2

9.35e-04361003PS50221
DomainGPS

PKD1L1 CELSR1 CELSR2

1.01e-03371003IPR000203
DomainSH3

DLG5 SNX33 DLG1 PLCG1 PLCG2 UBASH3B

1.08e-032161006SM00326
DomainLAM_G_DOMAIN

LAMA5 CELSR1 CELSR2

1.10e-03381003PS50025
DomainLaminin_EGF

LAMA5 CELSR1 CELSR2

1.10e-03381003IPR002049
PathwayWP_MESODERMAL_COMMITMENT_PATHWAY

TCF4 MTF2 JARID2 SETD2 DKK1 YAP1 MACF1

1.65e-05153757M39546
PathwayWP_INTERACTOME_OF_POLYCOMB_REPRESSIVE_COMPLEX_2_PRC2

MTF2 TRIM35 JARID2

7.71e-0516753M39484
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

DLG5 KIF26B YTHDC2 KANK2 MACF1 EIF3A CTNND1 ARHGAP21

2.01e-07209102836779422
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

REPS1 GEMIN5 RFX1 BPTF NCOR1 SETD2 YAP1 DLG1 QSER1 CTNND1 EXOC4

6.70e-075491021138280479
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

TCF4 TBX4 MTF2 BACH2 MLLT10 RFX1 ZC3H6 MXD4 JARID2 BPTF NCOR1 ZFP36L1 PLCG1

7.29e-078081021320412781
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

FRAS1 GBF1 REPS1 LAMA5 GEMIN5 MLLT10 ITGB4 MXD4 FANCA NCOR1 CELSR1 CELSR2 SBF2 PLCG1 ARHGAP21

8.15e-0711051021535748872
Pubmed

TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk.

PLCG1 PLCG2 UBASH3B

8.50e-077102327609517
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

GBF1 MYOM1 FXR2 PKD1L1 GEMIN5 YTHDC2 KANK2 MACF1 EIF3A

1.24e-06361102926167880
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

ABCC1 PKP4 PI4K2A SNX33 FANCA USP31 YAP1 DLG1 MACF1 FLRT3 CTNND1 ARHGAP21

1.38e-067191021235337019
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

DLG5 REPS1 PKP4 LAMA5 GEMIN5 YTHDC2 PFKL KANK2 JARID2 SETD2 CELSR1 PXDN PLPP2 DLG1 MACF1 EIF3A AFF4

1.63e-0614971021731527615
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

ABCC1 FXR2 LYSMD3 KANK2 FRMD4B SETD2 TEX264 CLMN YAP1 DLG1 QSER1 CTNND1

1.68e-067331021234672954
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

GBF1 PI4K2A GEMIN5 YTHDC2 SNX33 RFX1 PITPNM1 BPTF NCOR1 SETD2 YAP1 DLG1

2.94e-067741021215302935
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

GEMIN5 MARCHF7 PFKL ABLIM3 ITGB4 TEX264 CLMN SBF2 DLG1 MACF1 PLCG1 QSER1 ARHGAP21 AFF4

3.49e-0610841021411544199
Pubmed

BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.

DLG5 GBF1 GEMIN5 YTHDC2 KANK2 EIF3A CTNND1

3.62e-06216102731519766
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

ABCC1 PKP4 USP31 CELSR2 DLG1 MACF1 CTNND1 ARHGAP21 EXOC4

4.35e-06421102936976175
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

FXR2 PKP4 ABLIM3 KANK2 NCOR1 CELSR2 DLG1 MACF1 QSER1 CTNND1 UBASH3B ARHGAP21 AFF4

4.99e-069631021328671696
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

DLG5 PKP4 ABLIM3 KANK2 CLMN YAP1 DLG1 MACF1 CTNND1 ARHGAP21

6.61e-065651021025468996
Pubmed

A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure.

CELSR1 DKK1 CELSR2

6.86e-0613102326989192
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

TCF4 GBF1 SNX33 PFKL RFX1 KANK2 MXD4 BPTF NCOR1 RNASEL QSER1 CTNND1

8.24e-068571021225609649
Pubmed

Phospholipase C gamma 2 is essential for specific functions of Fc epsilon R and Fc gamma R.

PLCG1 PLCG2

8.52e-062102212471105
Pubmed

The junctional epithelium originates from the odontogenic epithelium of an erupted tooth.

LAMA5 ITGB4

8.52e-062102224785116
Pubmed

Equilibrative nucleoside transporter 3 supports microglial functions and protects against the progression of Huntington's disease in the mouse model.

SLC29A3 CX3CR1

8.52e-062102238925413
Pubmed

Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking.

CELSR1 CELSR2

8.52e-062102223292348
Pubmed

Dlg1 deletion in microglia ameliorates chronic restraint stress induced mice depression-like behavior.

DLG1 CX3CR1

8.52e-062102236909184
Pubmed

Expression of DLG1 and DLG5 in the Intestinal Epithelium of Patients with CD.

DLG5 DLG1

8.52e-062102227760079
Pubmed

Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin.

PKP4 CTNND1

8.52e-062102217264675
Pubmed

Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation.

MTF2 JARID2

8.52e-062102233887196
Pubmed

Dlg1 Knockout Inhibits Microglial Activation and Alleviates Lipopolysaccharide-Induced Depression-Like Behavior in Mice.

DLG1 CX3CR1

8.52e-062102234490521
Pubmed

The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors.

PLCG1 PLCG2

8.52e-062102215972651
Pubmed

Extracellular proteolysis of reelin by tissue plasminogen activator following synaptic potentiation.

RELN PLAT

8.52e-062102224892761
Pubmed

Molecular species of phospholipids in a murine stem-cell line responsive to erythropoietin.

PLCG1 PLCG2

8.52e-06210228615781
Pubmed

Fibroblasts inhibit osteogenesis by regulating nuclear-cytoplasmic shuttling of YAP in mesenchymal stem cells and secreting DKK1.

DKK1 YAP1

8.52e-062102238245803
Pubmed

Restoration of responsiveness of phospholipase Cγ2-deficient platelets by enforced expression of phospholipase Cγ1.

PLCG1 PLCG2

8.52e-062102225793864
Pubmed

Expression of filaggrin-2 protein in the epidermis of human skin diseases: a comparative analysis with filaggrin.

FLG FLG2

8.52e-062102224813994
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

DLG5 GBF1 KIF26B USP31 ZFP36L1 CLMN YAP1 FAM83G MACF1 CTNND1 ARHGAP21 EXOC4

8.63e-068611021236931259
Pubmed

Functional proteomics mapping of a human signaling pathway.

FLI1 TBX4 MTF2 LAMA5 PFKL RFX1 NCOR1 DKK1 MACF1 PLCG2

9.77e-065911021015231748
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

PKP4 GEMIN5 YTHDC2 PFKL ABLIM3 KANK2 PITPNM1 USP31 CLMN DLG1 MACF1 EIF3A CTNND1 ARHGAP21 EXOC4

1.84e-0514311021537142655
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

REPS1 GEMIN5 YTHDC2 PFKL SETD2 CLMN MACF1 EIF3A PLCG1 CTNND1 ARHGAP21 AFF4

1.93e-059341021233916271
Pubmed

A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1.

FRAS1 LAMA5 FREM3

1.94e-0518102314730302
Pubmed

Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.

MTF2 TRIM35 JARID2

1.94e-0518102320064376
Pubmed

Polymorphisms in CFH, HTRA1 and CX3CR1 confer risk to exudative age-related macular degeneration in Han Chinese.

CFH CX3CR1

2.55e-053102220538655
Pubmed

Evolutionary forces shape the human RFPL1,2,3 genes toward a role in neocortex development.

RFPL3 RFPL2

2.55e-053102218656177
Pubmed

Phospholipase Cγ2 plays a role in TCR signal transduction and T cell selection.

PLCG1 PLCG2

2.55e-053102222837484
Pubmed

Dlg1, Sec8, and Mtmr2 regulate membrane homeostasis in Schwann cell myelination.

DLG1 EXOC4

2.55e-053102219587293
Pubmed

Real time fluorescence imaging of PLC gamma translocation and its interaction with the epidermal growth factor receptor.

PLCG1 PLCG2

2.55e-053102211331309
Pubmed

GATA3 regulates FLG and FLG2 expression in human primary keratinocytes.

FLG FLG2

2.55e-053102228928464
Pubmed

The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development.

CELSR1 CELSR2

2.55e-053102211677057
Pubmed

Spleen tyrosine kinase influences the early stages of multilineage differentiation of bone marrow stromal cell lines by regulating phospholipase C gamma activities.

PLCG1 PLCG2

2.55e-053102228786489
Pubmed

Tau complexes with phospholipase C-gamma in situ.

PLCG1 PLCG2

2.55e-05310229592050
Pubmed

Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.

FLG FLG2

2.55e-053102232437351
Pubmed

Expression profile of Fc receptor-like molecules in patients with IgA nephropathy.

FCRL1 FCRL3

2.55e-053102233597097
Pubmed

PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming.

MTF2 JARID2

2.55e-053102221732481
Pubmed

Globular domains 4/5 of the laminin alpha3 chain mediate deposition of precursor laminin 5.

LAMA5 ITGB4

2.55e-053102215316072
Pubmed

Anti-inflammatory genes associated with multiple sclerosis: a gene expression study.

BACH2 ZFP36L1

2.55e-053102225670004
Pubmed

Differential and nonredundant roles of phospholipase Cgamma2 and phospholipase Cgamma1 in the terminal maturation of NK cells.

PLCG1 PLCG2

2.55e-053102217015722
Pubmed

Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.

FLG FLG2

2.55e-053102223403047
Pubmed

FLI1 induces erythroleukemia through opposing effects on UBASH3A and UBASH3B expression.

FLI1 UBASH3B

2.55e-053102238461240
Pubmed

PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development.

PLCG1 PLCG2

2.55e-053102229133930
Pubmed

SH3BP2 mutations potentiate osteoclastogenesis via PLCγ.

PLCG1 PLCG2

2.55e-053102220872577
Pubmed

Potential role of Gab1 and phospholipase C-gamma in osmotic shock-induced glucose uptake in 3T3-L1 adipocytes.

PLCG1 PLCG2

2.55e-053102211507676
Pubmed

A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase.

PLCG1 PLCG2

2.55e-053102210770799
Pubmed

Expression of Fraser syndrome genes in normal and polycystic murine kidneys.

FRAS1 FREM3

2.55e-053102221993971
Pubmed

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.

REPS1 FXR2 PFKL ABLIM3 DLG1 MACF1 CTNND1 ARHGAP21

4.07e-05430102832581705
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

CCDC14 DLG5 FXR2 BACH2 PKP4 PKD1L1 KANK2 NCOR1 FAM83G ARHGAP21 EXOC4

4.25e-058531021128718761
Pubmed

Mutation specific functions of EGFR result in a mutation-specific downstream pathway activation.

ABLIM3 PLCG1 CTNND1 UBASH3B

4.92e-0568102425754235
Pubmed

An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion.

PLCG1 PLCG2

5.09e-054102215372077
Pubmed

Silencing mediator for retinoid and thyroid hormone receptor and nuclear receptor corepressor attenuate transcriptional activation by the beta-catenin-TCF4 complex.

TCF4 NCOR1

5.09e-054102218632669
Pubmed

Ca(2+)-dependent reduction of glutamate aspartate transporter GLAST expression in astrocytes by P2X(7) receptor-mediated phosphoinositide 3-kinase signaling.

PLCG1 PLCG2

5.09e-054102220070863
Pubmed

ESCRT machinery potentiates HIV-1 utilization of the PI(4,5)P(2)-PLC-IP3R-Ca(2+) signaling cascade.

PLCG1 PLCG2

5.09e-054102221875593
Pubmed

Integrin alpha6beta4-erbB2 complex inhibits haptotaxis by up-regulating E-cadherin cell-cell junctions in keratinocytes.

LAMA5 ITGB4

5.09e-054102215579904
Pubmed

The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis.

TCF4 MLLT10

5.09e-054102221103407
Pubmed

The armadillo protein p0071 regulates Rho signalling during cytokinesis.

PKP4 CTNND1

5.09e-054102217115030
Pubmed

The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.

CELSR1 CELSR2

5.09e-054102237224017
Pubmed

Differential localization profile of Fras1/Frem proteins in epithelial basement membranes of newborn and adult mice.

FRAS1 FREM3

5.09e-054102218563433
Pubmed

Dephosphorylation of the adaptor LAT and phospholipase C-γ by SHP-1 inhibits natural killer cell cytotoxicity.

PLCG1 PLCG2

5.09e-054102227221712
Pubmed

Action of TFII-I outside the nucleus as an inhibitor of agonist-induced calcium entry.

PLCG1 PLCG2

5.09e-054102217023658
Pubmed

Phospholipase C gamma-2 (Plcg2) and phospholipase C gamma-1 (Plcg1) map to distinct regions in the human and mouse genomes.

PLCG1 PLCG2

5.09e-05410227774933
Pubmed

Segmental and restricted localization pattern of Fras1 in the developing meningeal basement membrane in mouse.

FRAS1 FREM3

5.09e-054102224101214
Pubmed

Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators.

RELN PLAT

5.09e-054102223082219
Pubmed

Reduced expression of E-cadherin and p120-catenin and elevated expression of PLC-γ1 and PIKE are associated with aggressiveness of oral squamous cell carcinoma.

PLCG1 CTNND1

5.09e-054102226464646
Pubmed

A2E accumulation influences retinal microglial activation and complement regulation.

CFH CX3CR1

5.09e-054102222819137
Pubmed

Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites.

PLCG1 PLCG2

5.09e-05410229398617
Pubmed

Phospholipase Cgamma2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase.

PLCG1 PLCG2

5.09e-054102218378693
Pubmed

Transglutaminase Interaction with α6/β4-Integrin Stimulates YAP1-Dependent ΔNp63α Stabilization and Leads to Enhanced Cancer Stem Cell Survival and Tumor Formation.

ITGB4 YAP1

5.09e-054102227780825
Pubmed

CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells.

TCF4 CX3CR1

5.09e-054102220679228
Pubmed

Developmental expression profiles of Celsr (Flamingo) genes in the mouse.

CELSR1 CELSR2

5.09e-054102211850187
Pubmed

Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice.

PLCG1 PLCG2

5.09e-054102211744703
Pubmed

A single-cell time-lapse of mouse prenatal development from gastrula to birth.

CFH RELN TBX4

5.37e-0525102338355799
Pubmed

Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.

PKP4 ITGB4 PLCG1 CTNND1

7.22e-0575102415951569
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

DLG5 REPS1 RFX1 KANK2 BPTF MACF1 CTNND1 ARHGAP21

7.81e-05472102838943005
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

FLG EML6 MYRIP SCML4 BPTF NCOR1 PXDN MTTP KRT20 DLG1 MACF1 ATG4C EIF3A ARHGAP21

8.18e-0514421021435575683
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

CCDC14 DLG5 ZBTB9 YTHDC2 QSER1 EXOC4

8.23e-05242102634011540
Pubmed

Mapping of the bcl-2 oncogene on mouse chromosome 1.

CFH REN

8.47e-05510222895697
Pubmed

Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia.

FCRL1 FCRL3

8.47e-055102218704934
Pubmed

The EWS/FLI1 oncogenic protein inhibits expression of the Wnt inhibitor DICKKOPF-1 gene and antagonizes beta-catenin/TCF-mediated transcription.

FLI1 DKK1

8.47e-055102220019092
Pubmed

Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase C.

PLCG1 PLCG2

8.47e-055102220719962
Pubmed

Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia.

FCRL1 FCRL3

8.47e-055102216849395
Pubmed

IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells.

FCRL1 FCRL3

8.47e-055102211929751
Pubmed

LAB: a new membrane-associated adaptor molecule in B cell activation.

PLCG1 PLCG2

8.47e-055102212514734
Pubmed

Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity.

PLCG1 PLCG2

8.47e-05510229819383
Pubmed

Duplications on human chromosome 22 reveal a novel Ret Finger Protein-like gene family with sense and endogenous antisense transcripts.

RFPL3 RFPL2

8.47e-055102210508838
Pubmed

Spatiotemporal distribution of Fras1/Frem proteins during mouse embryonic development.

FRAS1 FREM3

8.47e-055102217251066
InteractionC2CD4B interactions

FRAS1 SETD2 CELSR1 CELSR2 MACF1

2.66e-06441015int:C2CD4B
InteractionWEE2-AS1 interactions

FLG GBF1 FXR2 FLG2 EIF3A CTNND1 EXOC4

1.81e-051631017int:WEE2-AS1
InteractionLCK interactions

DLG5 TRIM35 PKP4 PFKL DLG1 MACF1 PLCG1 PLCG2 CTNND1 ARHGAP21 EXOC4

2.07e-0546310111int:LCK
InteractionC11orf52 interactions

ABCC1 DLG5 PKP4 USP31 DLG1 MACF1 FLRT3 CTNND1 ARHGAP21

2.66e-053111019int:C11orf52
InteractionAFDN interactions

DLG5 PKP4 ABLIM3 FRMD4B YAP1 DLG1 MACF1 CTNND1 ARHGAP21

4.54e-053331019int:AFDN
InteractionLYN interactions

ABCC1 DLG5 KIF26B PKP4 KANK2 USP31 YAP1 DLG1 MACF1 PLCG1 PLCG2 CTNND1 ARHGAP21

6.26e-0572010113int:LYN
InteractionSIRPD interactions

FRAS1 LAMA5 ITGB4 CELSR1 CELSR2

7.23e-05861015int:SIRPD
InteractionEPB41L4A interactions

DLG5 PKP4 KANK2 DLG1 MACF1 CTNND1

7.44e-051401016int:EPB41L4A
GeneFamilyAdhesion G protein-coupled receptors, subfamily C|CELSR cadherins

CELSR1 CELSR2

4.68e-053722913
GeneFamilyAdhesion G protein-coupled receptors, subfamily C|CELSR cadherins

CELSR1 CELSR2

4.68e-0537221189
GeneFamilyEF-hand domain containing|S100 fused type protein family

FLG FLG2

3.24e-0477221350
GeneFamilyEF-hand domain containing

FLG REPS1 FLG2 MACF1 PLCG1

1.80e-03219725863
GeneFamilyPhospholipases|C2 domain containing phospholipases

PLCG1 PLCG2

2.56e-0319722832
GeneFamilyPDZ domain containing

DLG5 PREX2 DLG1 ARHGAP21

3.17e-031527241220
GeneFamilyCalcium voltage-gated channel subunits|Membrane associated guanylate kinases

DLG5 DLG1

4.78e-0326722904
GeneFamilyPHD finger proteins

MTF2 MLLT10 BPTF

5.55e-039072388
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

ABCC1 GBF1 MTF2 PKP4 MARCHF7 ABLIM3 JARID2 BPTF SETD2 DKK1 YAP1 DLG1 MACF1 EIF3A

5.85e-0685610214M4500
CoexpressionDURCHDEWALD_SKIN_CARCINOGENESIS_DN

ABCC1 FAM83G DLG1 MACF1 FLRT3 CTNND1 UBASH3B AFF4

9.49e-062651028M1684
CoexpressionDURCHDEWALD_SKIN_CARCINOGENESIS_DN

ABCC1 FAM83G DLG1 MACF1 FLRT3 CTNND1 UBASH3B AFF4

1.15e-052721028MM1027
CoexpressionGSE22886_TH1_VS_TH2_48H_ACT_UP

BACH2 POM121L2 PREX2 KRT20 FLRT3 PLCG2 RFPL3

1.27e-051981027M4510
CoexpressionGSE360_CTRL_VS_B_MALAYI_LOW_DOSE_DC_UP

CFH MYRIP REN BPTF DKK1 ZFP36L1 EIF3A

1.27e-051981027M5152
CoexpressionGSE32986_CURDLAN_LOWDOSE_VS_GMCSF_AND_CURDLAN_LOWDOSE_STIM_DC_UP

SLC29A3 PKP4 LYSMD3 ZC3H6 FCRL1 ATG4C EXOC4

1.36e-052001027M8625
CoexpressionGSE4984_UNTREATED_VS_LPS_TREATED_DC_UP

FRMD4B CELSR1 CLMN SBF2 MTTP PLCG2

2.83e-051511026M6498
CoexpressionLAKE_ADULT_KIDNEY_C5_PROXIMAL_TUBULE_EPITHELIAL_CELLS_STRESS_INFLAM

FRAS1 FXR2 KIF26B MYRIP PFKL ZC3H6 FRMD4B NCOR1 PLCG2

3.72e-054171029M39224
CoexpressionGSE7568_CTRL_VS_3H_TGFB_TREATED_MACROPHAGES_WITH_IL4_AND_DEXAMETHASONE_DN

LRRC66 YTHDC2 RFX1 MACF1 ATG4C PLCG1

4.97e-051671026M361
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

GBF1 BPTF NCOR1 SETD2 CELSR2 MACF1

7.53e-051801026M8239
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP

PREX2 JARID2 ZFP36L1 CLMN PLAT PLCG2

8.50e-051841026M8544
CoexpressionHE_LIM_SUN_FETAL_LUNG_C3_GRIA2_POS_ARTERIAL_ENDO_CELL

CFH LAMA5 ITGB4 PREX2 PLCG2

8.84e-051151025M45752
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP

PREX2 JARID2 ZFP36L1 CLMN PLAT PLCG2

9.57e-051881026MM983
CoexpressionBENPORATH_NANOG_TARGETS

GBF1 MARCHF7 MLLT10 RFX1 FANCA JARID2 NCOR1 KATNBL1 DKK1 ZFP36L1 YAP1 ATG4C EXOC4

1.20e-0498810213M6616
CoexpressionGSE22886_TCELL_VS_BCELL_NAIVE_DN

TCF4 DLG5 FRAS1 KATNBL1 CLMN PLCG2

1.27e-041981026M4426
CoexpressionGSE40274_FOXP3_VS_FOXP3_AND_GATA1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN

ABCC1 TCF4 FXR2 PKP4 GEMIN5 CELSR2

1.31e-041991026M9180
CoexpressionGSE23502_BM_VS_COLON_TUMOR_MYELOID_DERIVED_SUPPRESSOR_CELL_DN

CCDC14 FLI1 MTF2 BACH2 FCRL1 CELSR2

1.34e-042001026M8088
CoexpressionGSE23502_WT_VS_HDC_KO_MYELOID_DERIVED_SUPPRESSOR_CELL_BM_UP

FLI1 PKP4 MXD4 FCRL1 ZFP36L1 SLAIN1

1.34e-042001026M8090
CoexpressionGSE41176_WT_VS_TAK1_KO_ANTI_IGM_STIM_BCELL_6H_UP

FLI1 MYOM1 MARCHF7 KRT20 FLRT3 AFF4

1.34e-042001026M9942
CoexpressionGSE17721_0.5H_VS_24H_CPG_BMDC_DN

REPS1 MTF2 PKP4 LYSMD3 ARHGAP21 CX3CR1

1.34e-042001026M4129
CoexpressionIWANAGA_CARCINOGENESIS_BY_KRAS_DN

TCF4 PCDHB12 ITGB4 SCML4 FCRL1

1.36e-041261025M9362
CoexpressionZHENG_BOUND_BY_FOXP3

FLI1 LRRC66 FRMD4B SCML4 JARID2 MACF1 PLCG1 UBASH3B CX3CR1

1.44e-044981029M1741
CoexpressionZHENG_BOUND_BY_FOXP3

FLI1 LRRC66 FRMD4B SCML4 JARID2 MACF1 PLCG1 UBASH3B CX3CR1

1.65e-045071029MM1030
CoexpressionIWANAGA_CARCINOGENESIS_BY_KRAS_DN

TCF4 PCDHB12 ITGB4 SCML4 FCRL1

1.88e-041351025MM753
CoexpressionLAKE_ADULT_KIDNEY_C22_ENDOTHELIAL_CELLS_GLOMERULAR_CAPILLARIES

TCF4 PREX2 SBF2 MACF1 PLAT

2.01e-041371025M39241
CoexpressionGSE37532_VISCERAL_ADIPOSE_TISSUE_VS_LN_DERIVED_PPARG_KO_TREG_CD4_TCELL_DN

SLC29A3 BACH2 SCML4 PITPNM1 FLRT3

2.15e-041391025M8948
CoexpressionAtlasDevelopingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_emap-3087_k-means-cluster#1_top-relative-expression-ranked_1000

FLI1 TCF4 TBX4 KIF26B BACH2 PCDHB12 NCOR1 DKK1 FLRT3

1.62e-062291029gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_1000_k1
CoexpressionAtlasDevelopingGonad_e12.5_ovary_emap-28876_top-relative-expression-ranked_500

CFH TBX4 MTF2 PKP4 PFKL LYSMD3 FRMD4B SLITRK1 KATNBL1 EIF3A

2.77e-0540910210gudmap_developingGonad_e12.5_ovary_500
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_1000

CFH MTF2 PKP4 GEMIN5 REN PFKL LYSMD3 FRMD4B KATNBL1 RNASEL CLMN EIF3A UBASH3B CX3CR1

2.89e-0580110214gudmap_developingGonad_e14.5_ epididymis_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_top-relative-expression-ranked_500

TBX4 KIF26B TRIM35 BACH2 PCDHB12 MYRIP KANK2 DDC USP31 FLRT3

3.20e-0541610210gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_500
CoexpressionAtlasFacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_1000_k-means-cluster#3

REPS1 KIF26B PKP4 REN PREX2 FANCA DLG1 MACF1 EIF3A QSER1

4.40e-0543210210Facebase_RNAseq_e10.5_Maxillary Arch_1000_K3
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#4_top-relative-expression-ranked_500

PKP4 PFKL LYSMD3 FRMD4B KATNBL1 RNASEL

9.32e-051521026gudmap_developingGonad_e18.5_epididymis_500_k4
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#1_top-relative-expression-ranked_500

PFKL FRMD4B KATNBL1 CLMN

9.75e-05501024gudmap_developingGonad_e14.5_ epididymis_500_k1
CoexpressionAtlasDevelopingGonad_e12.5_ovary_emap-28876_top-relative-expression-ranked_1000

CFH TBX4 MTF2 PKP4 YTHDC2 PFKL LYSMD3 FRMD4B SLITRK1 KATNBL1 RNASEL CLMN EIF3A

1.25e-0480410213gudmap_developingGonad_e12.5_ovary_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_emap-3087_k-means-cluster#3_top-relative-expression-ranked_500

FLI1 TBX4 KIF26B PCDHB12 DKK1

1.40e-041031025gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_500_k3
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_top-relative-expression-ranked_500

CFH PKP4 REN PFKL LYSMD3 FRMD4B KATNBL1 RNASEL EIF3A

1.49e-044061029gudmap_developingGonad_e16.5_epididymis_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_emap-3087_top-relative-expression-ranked_1000

FLI1 TCF4 TBX4 KIF26B BACH2 PCDHB12 MYRIP DDC SLITRK1 NCOR1 DKK1 SLAIN1 FLRT3

1.65e-0482710213gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_1000
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_500

CFH PKP4 REN PFKL LYSMD3 FRMD4B KATNBL1 RNASEL CLMN

1.70e-044131029gudmap_developingGonad_e14.5_ epididymis_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_top-relative-expression-ranked_500

FLI1 TCF4 TBX4 KIF26B PCDHB12 ZC3H6 NCOR1 DKK1 FLRT3

2.25e-044291029gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#4_top-relative-expression-ranked_500

TBX4 KIF26B PCDHB12 FLRT3

2.56e-04641024gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_500_k4
CoexpressionAtlaslymph node

BACH2 EML6 SCML4 FCRL1 FCRL3 ANKRD34B PLCG2

3.14e-042681027lymph node
CoexpressionAtlasDevelopingGonad_P2_ovary_emap-30224_top-relative-expression-ranked_1000

CFH PKP4 MYRIP GEMIN5 YTHDC2 LYSMD3 FRMD4B SLITRK1 KATNBL1 UNC13C PLCG2 UBASH3B

3.23e-0477010212gudmap_developingGonad_P2_ovary_1000
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TCF4 TBX4 ABLIM3 FRMD4B ZFP36L1 SBF2 MACF1 PLAT UNC13C

7.57e-101941039b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCellCOVID-19-lung-Vein_EC|lung / Disease (COVID-19 only), tissue and cell type

FLI1 TCF4 PKP4 MYRIP ABLIM3 ITGB4 PREX2 PLAT

1.36e-081881038d582b76fc2faac526c9bf97503041129e1a6a211
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

TCF4 TBX4 ABLIM3 FRMD4B SBF2 MACF1 PLAT UNC13C

1.80e-0819510380e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCellFetal_29-31_weeks|World / Lineage, Cell type, age group and donor

CFH TCF4 FRAS1 KIF26B BACH2 PXDN YAP1 UNC13C

2.11e-0819910385b9d355795dd03a22f0961dfd143425c367a4654
ToppCellCOPD-Epithelial-Basal|Epithelial / Disease state, Lineage and Cell class

ABCC1 TCF4 TRIM35 BACH2 ITGB4 FRMD4B USP31

1.94e-071781037441d1dba720141891b11f404744c59834d80e6c5
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DLG5 DLG1 MACF1 PLCG2 CTNND1 ARHGAP21 AFF4

2.01e-0717910376e965e424eebef50f0202cff75f458be395cfca1
ToppCellFetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FLI1 TCF4 KIF26B LAMA5 USP31 PXDN PLAT

2.09e-071801037d8ef44710a77ad0fc03243428e5e1dc4d41200cb
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLI1 FRMD4B PREX2 PLPP2 ZFP36L1 CLMN CX3CR1

2.91e-07189103742ab4cc5fbf8580841f31889446fe4499df1a464
ToppCellCOVID-19-lung-Vein_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

FLI1 TCF4 PKP4 MYRIP ITGB4 PREX2 PLAT

3.02e-0719010371caeaef78326734c1e31a0c4739190d5c5a77b9e
ToppCellCOVID_vent-Lymphocytic-B_cell|COVID_vent / Disease condition, Lineage, Cell class and subclass

TCF4 BACH2 CELSR1 FCRL1 FCRL3 ZFP36L1 PLCG2

3.02e-07190103740b5e9e8f8fd8d84cb5b43e67b49267082348e9f
ToppCellCOVID_vent-Lymphocytic-B_cell-|COVID_vent / Disease condition, Lineage, Cell class and subclass

TCF4 BACH2 CELSR1 FCRL1 FCRL3 ZFP36L1 PLCG2

3.02e-071901037a37a32dc1b931562a6660074e19d5598efc65284
ToppCellPCW_13-14|World / Celltypes from embryonic and fetal-stage human lung

CFH TCF4 ABLIM3 NCOR1 YAP1 MACF1 UNC13C

3.02e-07190103762a3ec1ae0829602b0569cc051210551644f1d46
ToppCellFetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FLI1 TCF4 KIF26B PKP4 PREX2 USP31 PXDN

3.35e-071931037ad2df9b77999780860141be6ec366afc0172a331
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TCF4 FRMD4B ZFP36L1 YAP1 SBF2 MACF1 UNC13C

3.85e-07197103731a1852911bda38543916585fda34255fd62a134
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_basal-Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TCF4 DLG5 FRAS1 ITGB4 USP31 CELSR1 CLMN

3.85e-0719710371e915957ea6a4550ecb9d6ee4b232aa5800faf20
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TCF4 FRAS1 FRMD4B YAP1 SBF2 MACF1 UNC13C

3.85e-0719710370034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCellIPF-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

CFH TCF4 KIF26B ABLIM3 FRMD4B YAP1 MACF1

3.85e-071971037f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors|1_mon / Sample Type, Dataset, Time_group, and Cell type.

BACH2 PKP4 JARID2 BPTF CELSR1 PXDN YAP1

4.12e-071991037358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FLI1 TCF4 PKP4 PREX2 BPTF MACF1 CTNND1

4.26e-072001037dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellTracheal|World / Cell types per location group and 10X technology with lineage, and cell group designations

CFH DLG5 PKP4 MYRIP ITGB4 PLPP2 SBF2

4.26e-072001037682960e28542a3d6c119047cd0131941932cfdea
ToppCellControl_saline-Endothelial-Endothelial-Gen_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

FLI1 TCF4 PKP4 PREX2 BPTF MACF1 CTNND1

4.26e-0720010373b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Gen_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FLI1 TCF4 PKP4 PREX2 BPTF MACF1 CTNND1

4.26e-072001037a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-epithelial_cell_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 LAMA5 CELSR1 FCRL1 DKK1 CX3CR1

1.65e-0615510360e24e767a3895d31d34cabeaca0354aadae34e44
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-Lgr5-_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 LAMA5 CELSR1 FCRL1 DKK1 CX3CR1

1.65e-061551036f3489a548a2c0cc2d9117ff85865c6089ea0835d
ToppCellChildren_(3_yrs)-Epithelial-basal_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CFH FRAS1 LAMA5 ITGB4 CELSR1 FLRT3

1.84e-061581036d78e7e52657dc094430291fec07e9c298be9e584
ToppCellHippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Hippocampus / BrainAtlas - Mouse McCarroll V32

RELN FREM3 ABLIM3 ANKRD34B KRT20 UBASH3B

2.05e-061611036b81b346309f3facbfbebd91cae4c5b33c7bd24ef
ToppCellEndothelial-endothelial_cell_of_bronchial_vessel|World / Lineage, Cell type, age group and donor

FLI1 TCF4 PKP4 MYRIP ITGB4 PREX2

2.37e-06165103684e553d699ac56df89a77248f7308b9133e1b683
ToppCellControl-B_cells-Activated_B_cells|Control / group, cell type (main and fine annotations)

TCF4 BACH2 EML6 FCRL1 FCRL3 PLCG2

2.63e-061681036a7159a35fe37f8c241cf8d391debe271e0698105
ToppCellControl-Epithelial_cells-Airway_basal|Control / group, cell type (main and fine annotations)

CFH FRAS1 ITGB4 USP31 CELSR1 UNC13C

2.91e-0617110363965ced4be6db14265a90673502fceee425837ca
ToppCellEpithelial-basal_cell|World / Lineage, Cell type, age group and donor

CFH FRAS1 LAMA5 ITGB4 CELSR1 PLPP2

3.79e-061791036d9be6647ec7b22747dc00dce4ea307b6af412dfa
ToppCellMesenchymal_cells-Stromal_fibro.|Mesenchymal_cells / Lineage and Cell class

TCF4 RELN SCML4 PLAT UNC13C UBASH3B

4.04e-061811036f8d914fdc06aaa75a4dc9158daf574ca28fa5432
ToppCellCOVID-19-Heart-EC_3|COVID-19 / Disease (COVID-19 only), tissue and cell type

FLI1 TCF4 PKP4 MYRIP PREX2 PLAT

4.30e-061831036ff95382cfed592190d0636d2b750328471f82e0d
ToppCellpdx|World / Sample and Cell Type and Tumor Cluster (all cells)

FRAS1 KIF26B JARID2 BPTF YAP1 DLG1

4.72e-061861036de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCellpdx-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

FRAS1 KIF26B JARID2 BPTF YAP1 DLG1

4.72e-0618610360b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCellCOVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

TCF4 PKP4 MYRIP ITGB4 PREX2 PLAT

4.87e-0618710362d20193a6cacdfa4877457c97b0077408942186c
ToppCelldroplet-Tongue-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCF4 LYSMD3 BPTF NCOR1 ZFP36L1 EIF3A

5.02e-061881036d62cc37e86b7b186e53aeb7f421c4e5ee28f23bd
ToppCellCOVID-19-Heart-EC_(POSTN)|COVID-19 / Disease (COVID-19 only), tissue and cell type

CFH FLI1 TCF4 MYRIP ITGB4 UNC13C

5.17e-0618910367346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCellCOVID-19-Heart-EC_3|Heart / Disease (COVID-19 only), tissue and cell type

FLI1 PKP4 MYRIP FRMD4B PREX2 PLAT

5.33e-06190103678e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLI1 FRMD4B PREX2 ZFP36L1 CLMN CX3CR1

5.50e-061911036a90c8ab2077e52bbc998457c85a1b9867f9c8c93
ToppCellCOVID-19-Heart-EC_(POSTN)|Heart / Disease (COVID-19 only), tissue and cell type

CFH FLI1 MYRIP ITGB4 FRMD4B UNC13C

5.66e-061921036c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCellhealthy_donor-Lymphocytic-B_cell|healthy_donor / Disease condition, Lineage, Cell class and subclass

TCF4 BACH2 EML6 LAMA5 FCRL1 FCRL3

5.66e-0619210367d9e5772b6e531b50ed4e4d6304ef11235f27f37
ToppCellLPS-antiTNF-Endothelial-Endothelial-Activated_Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLI1 PKP4 MYRIP PREX2 USP31 UBASH3B

5.66e-0619210360aeb5351275c0a91151ea2d52b2cdde172da6731
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-0|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TCF4 EML6 LAMA5 CELSR1 FCRL1 FCRL3

5.66e-06192103689b8ebdc285ed3c0f807fd1157271130d37dfa41
ToppCellhealthy_donor-Lymphocytic-B_cell-|healthy_donor / Disease condition, Lineage, Cell class and subclass

TCF4 BACH2 EML6 LAMA5 FCRL1 FCRL3

5.66e-061921036975312f9d6cede4d4f5b737e481e5c73accc8c50
ToppCelldroplet-Fat-Mat-18m-Endothelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PKP4 MYRIP LAMA5 ABLIM3 ITGB4 PREX2

5.83e-06193103654024a373e42e1c0bcc327dc084564b83b63a9d4
ToppCelldroplet-Fat-Mat-18m-Endothelial-endothelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PKP4 MYRIP LAMA5 ABLIM3 ITGB4 PREX2

5.83e-06193103681d908594d2983ba7e7c1ec25afdde4315d9690e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH FLI1 TCF4 MYRIP ITGB4 PREX2

5.83e-0619310362e72309607902dabe3218888b22a77fe941f3570
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FLI1 TCF4 MYRIP ITGB4 PREX2 PLAT

5.83e-0619310369ba688b35a9ead5d04691b3f3f15484f02dbbd0d
ToppCell5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TCF4 MYRIP LAMA5 ABLIM3 PREX2 PLAT

5.83e-061931036c0973a2c97deb7176c2f617c8760a55f7edc9839
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

FRAS1 JARID2 BPTF DLG1 PLCG2 AFF4

5.83e-061931036e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCellMesenchymal-matrix_fibroblast_1_cell|World / Lineage, Cell type, age group and donor

TCF4 FRAS1 TBX4 BACH2 ABLIM3 UNC13C

5.83e-061931036acad568621ed677031797b8c2e34dafea798d681
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLI1 TCF4 PKP4 PREX2 MACF1 CTNND1

6.01e-0619410360b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCellLPS_only-Endothelial|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLI1 TCF4 PKP4 PREX2 USP31 CTNND1

6.01e-06194103658f069efdefa0366033764446b9d6ffd4a17807e
ToppCellLPS_only-Endothelial-Endothelial|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLI1 TCF4 PKP4 PREX2 USP31 CTNND1

6.01e-061941036bfd92ec75facb0ba55c31e5f2e089d983b3d0169
ToppCelldroplet-Fat-Mat-18m-Endothelial-Cd36+|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PKP4 MYRIP LAMA5 ABLIM3 ITGB4 PREX2

6.01e-06194103674d0eaa76f6d9af14110dfe5b4bf9751b99ff6e3
ToppCellIPF-Endothelial-VE_Peribronchial|World / Disease state, Lineage and Cell class

TCF4 PKP4 MYRIP PREX2 PXDN PLAT

6.19e-061951036120296531bbc8080dcabacbd64733cc1dc34603a
ToppCellCOVID-19-kidney-PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

FLI1 TCF4 PREX2 MACF1 PLAT PLCG2

6.19e-061951036a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCellIPF-Endothelial-VE_Peribronchial|IPF / Disease state, Lineage and Cell class

TCF4 PKP4 MYRIP PREX2 PXDN PLAT

6.19e-0619510362c3ad3cb79f11119ac69c413a938d21199145040
ToppCellbackground-Endothelial_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

FLI1 TCF4 RELN MYRIP PREX2 PXDN

6.19e-061951036c7d60dabfc7cb310e002cab10003dadfcc34fe33
ToppCellCOVID-19-Heart-EC_1|Heart / Disease (COVID-19 only), tissue and cell type

FLI1 TCF4 PKP4 LAMA5 ABLIM3 PREX2

6.19e-06195103650a193475db1bb1e05b8590225a553688c372c14
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLI1 TCF4 MYRIP ITGB4 PREX2 PLAT

6.19e-06195103677e47d2e8b3eb7f7c9620369ccaf87581f923bdb
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_basal-Basal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFH FRAS1 ITGB4 CELSR1 PLPP2 FLRT3

6.37e-061961036c5adab88140a465698abcbedc6505a43cae7bfd1
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TCF4 PKP4 MYRIP ABLIM3 PREX2 PLAT

6.37e-0619610365609b2d93172a488b35d854298a3a4e504e17e28
ToppCellbackground-Endothelial_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

FLI1 TCF4 RELN MYRIP PREX2 PXDN

6.37e-061961036e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-IPC/newborn-38|World / Primary Cells by Cluster

TCF4 EML6 FRMD4B CELSR2 QSER1 ARHGAP21

6.37e-06196103638da0751941adca650fe9b383d9f343153978eb5
ToppCellBasal_cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

DLG5 FRAS1 LAMA5 ITGB4 CELSR2 PLPP2

6.37e-0619610363b66f3a79b3f2ebacb4ad646f179e505ab38d6f0
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FLI1 TCF4 MYRIP FRMD4B PREX2 PLAT

6.37e-06196103622767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-IPC/newborn|World / Primary Cells by Cluster

TCF4 EML6 FRMD4B CELSR2 QSER1 ARHGAP21

6.37e-061961036721650a08d260faf530dbd52d4e9275d27f3bac2
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TCF4 FRMD4B ZFP36L1 SBF2 MACF1 UNC13C

6.37e-0619610361450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TCF4 RELN KIF26B FRMD4B PREX2 UBASH3B

6.37e-0619610367af6c5147ac859353504d19727dbe24f63a29dd4
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FLI1 TCF4 RELN FRMD4B PREX2 PLAT

6.37e-061961036145fcf73deba9638b391a1af6c39fa205dc9829f
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FLI1 TCF4 MYRIP FRMD4B PREX2 PLAT

6.37e-061961036adee900dcd16dbaba15c58bdcace09ba20214950
ToppCellBasal_cells|World / lung cells shred on cell class, cell subclass, sample id

CFH FRAS1 LAMA5 ITGB4 CELSR2 PLPP2

6.56e-06197103624360b660000bdfb999d58fbf4e29585a97e1785
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FLI1 TCF4 MYRIP ITGB4 PREX2 PLAT

6.56e-061971036b0036cf3f7e6edf8e43f16cd2f0f0e80471d2576
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma|TCGA-Pancreas / Sample_Type by Project: Shred V9

ABLIM3 ITGB4 PLPP2 ZFP36L1 YAP1 UBASH3B

6.56e-061971036d8355f07a53e771052f9ab6b38814365dfe8d9ae
ToppCell(6)_Endothelial-A_(Artery)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

TCF4 PKP4 MYRIP ITGB4 PREX2 PLAT

6.75e-06198103644f8cd5afa3685dcc8bfea0b15af5e8817e12e2e
ToppCellBronchial_Biopsy|World / Tissue, Lineage and Cell class of Lung Cells from 10X

TCF4 LAMA5 ITGB4 PLPP2 ZFP36L1 FLRT3

6.75e-061981036f5b7013045b61fc56894f80092f799770dde1c8f
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal-Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FRAS1 LAMA5 ITGB4 USP31 CELSR1 FLRT3

6.95e-06199103694a7867e800df352731796de8c24cba133c29622
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DLG5 LAMA5 ITGB4 PLPP2 PLAT PLCG2

6.95e-061991036c88a28a73f54dc571f2ff1e4b55073f83cbead2c
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Vein|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FLI1 TCF4 PKP4 MYRIP ITGB4 PREX2

6.95e-061991036cfb624c7728046fc7f3ef071f57e4d7b013f3fef
ToppCell367C-Endothelial_cells-Endothelial-A_(Artery)|367C / Donor, Lineage, Cell class and subclass (all cells)

TCF4 PKP4 MYRIP ITGB4 PREX2 PLAT

6.95e-06199103629ed081bd5204a32068b420f2244f3704891547b
ToppCell367C-Endothelial_cells-Endothelial-A_(Artery)-|367C / Donor, Lineage, Cell class and subclass (all cells)

TCF4 PKP4 MYRIP ITGB4 PREX2 PLAT

6.95e-061991036c2d85f80037f209a4a329790f475d9f98f590262
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Vein|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FLI1 PKP4 MYRIP ITGB4 PREX2 PLAT

7.15e-0620010367eb366b2c5394af7c77650bde6261e7dac67154e
ToppCellLPS_only-Endothelial-Endothelial-Vein|LPS_only / Treatment groups by lineage, cell group, cell type

TCF4 PKP4 MYRIP ITGB4 PREX2 PLAT

7.15e-062001036b036f5e22c95a3b14391785b6e91aa183b9bc9a8
ToppCellBiopsy_Other_PF-Epithelial-KRT5-/KRT17+|Biopsy_Other_PF / Sample group, Lineage and Cell type

KIF26B ITGB4 CELSR1 PXDN DKK1 PLPP2

7.15e-062001036077e6b9340686de9d0f11b035a8954e1f6a1b790
ToppCellNeuronal-Inhibitory|Neuronal / cells hierarchy compared to all cells using T-Statistic

TCF4 RELN KIF26B FRMD4B PREX2 UBASH3B

7.15e-0620010369ff8647e2de0b538e15929dca88ebb20ff7ab043
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FLI1 TCF4 PKP4 PREX2 MACF1 CTNND1

7.15e-0620010362d07237022b409c4fac6fcf99b68c8affb3007cd
ToppCellLPS_only-Endothelial-Endothelial-Gen_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

FLI1 TCF4 PKP4 PREX2 MACF1 CTNND1

7.15e-062001036eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCellLPS_only-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

FLI1 TCF4 PKP4 PREX2 MACF1 CTNND1

7.15e-06200103681e76508c9050d533853d5fd2f3097b27613d836
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

BPTF SETD2 MACF1 EIF3A PLCG2 AFF4

7.15e-06200103612f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell5'-Adult-SmallIntestine-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TCF4 RELN LAMA5 ABLIM3 PREX2 PLAT

7.15e-0620010362554b77edfe3d378296b0b25625caacbfb1c0e76
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FLI1 TCF4 PKP4 PREX2 BPTF CTNND1

7.15e-062001036b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCellNS-control|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CFH DLG5 ITGB4 CELSR1 YAP1 CTNND1

7.15e-062001036ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCellBronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_venous|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TCF4 PKP4 MYRIP LAMA5 ABLIM3 PREX2

7.15e-062001036a3b09580738783c6bff31ea33d5188912e56b8a7
ToppCellLPS_only-Endothelial-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

FLI1 TCF4 PKP4 PREX2 MACF1 CTNND1

7.15e-0620010364bb609a284d4e6066f17470a1736076aa4a1f84c
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac2_Myh4|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RELN KIF26B FRMD4B UNC13C UBASH3B

1.25e-051291035f83187c0bb06528127b8d2d56674ab1946846951
ToppCellLPS-IL1RA+antiTNF-Hematopoietic_Mast-Mast_cells-Mast-cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABCC1 FCRL3 PLAT PLCG2 UBASH3B

1.45e-05133103581189e8516a431d5890a0909f9fc7c82ec3442bc
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TCF4 CELSR1 FCRL1 FCRL3 KRT20

1.56e-0513510357743a01dc9c4542e910e7c0fe046004692a680bf
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-5|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TCF4 BACH2 CELSR1 FCRL1 FCRL3

2.94e-051541035020697ae8463b18f9b4270c404f52ce4c0e90135
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-midbrain/hindbrain_cells|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

RELN FREM3 ABLIM3 PLPP2 CLMN

2.94e-051541035df1b58a20af73fa79c6c069c0117a9ffd85b476f
Diseaselymphocyte count

FLI1 ABCC1 TCF4 FRAS1 SLC29A3 GBF1 BACH2 EML6 CPXCR1 DDC PREX2 SCML4 JARID2 NCOR1 SETD2 PLPP2 ZFP36L1 HFM1 UBASH3B CX3CR1

7.21e-0814649920EFO_0004587
DiseaseC-reactive protein measurement

TCF4 MTF2 ZBTB9 YTHDC2 MLLT10 KANK2 FANCA BPTF NCOR1 PXDN CELSR2 MACF1 HFM1 QSER1 ARHGAP21 AFF4

2.55e-0612069916EFO_0004458
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

TCF4 GABRQ NCOR1 DLG1

2.25e-0549994DOID:0060037 (implicated_via_orthology)
Diseaseurinary albumin to creatinine ratio

TCF4 MYOM1 MLLT10 ZFP36L1 SBF2 UNC13C

3.22e-05179996EFO_0007778
Diseasecholesterol:total lipids ratio, high density lipoprotein cholesterol measurement

GBF1 BPTF CELSR2 SBF2 MTTP MACF1 HFM1

4.15e-05276997EFO_0004612, EFO_0020943
Diseaseglycoprotein measurement

CFH POM121L2 PLCG1 UBASH3B ARHGAP21

5.18e-05119995EFO_0004555
Diseasehemoglobin A1 measurement

ABCC1 LRRC66 TCF4 DLG5 PFKL DDC SETD2 MACF1 UBASH3B

6.50e-05520999EFO_0007629
Diseaseresponse to perphenazine

C4orf54 PXDN CLMN

9.01e-0526993GO_0097334
Diseasegrip strength measurement

TCF4 GBF1 MLLT10 DDC JARID2 BPTF CELSR1

1.82e-04350997EFO_0006941
Diseasecolorectal cancer (is_marker_for)

SETD2 YAP1 KRT20 PLCG1 AFF4

1.91e-04157995DOID:9256 (is_marker_for)
DiseaseLeukemia, Myelocytic, Acute

BACH2 MLLT10 FANCA SETD2 PXDN

3.00e-04173995C0023467
DiseaseEmbryonal Rhabdomyosarcoma

SETD2 YAP1

3.08e-048992C0206656
DiseaseVitiligo

FLI1 SLC29A3 BACH2 FANCA

3.79e-04101994EFO_0004208
DiseaseQT interval

ABCC1 FRAS1 GBF1 KANK2 FRMD4B PXDN ARHGAP21 EXOC4

4.43e-04534998EFO_0004682
Diseasemonocyte count

FLI1 TCF4 MTF2 FXR2 MARCHF7 MLLT10 MXD4 PREX2 FANCA SETD2 HFM1 UBASH3B CX3CR1

4.69e-0413209913EFO_0005091
DiseaseFuchs endothelial corneal dystrophy

CFH TCF4

4.93e-0410992Orphanet_98974
Diseaseoverall survival, pancreatic carcinoma

SLITRK1 PREX2 SBF2

6.03e-0449993EFO_0000638, EFO_0002618
Diseaseserum alanine aminotransferase measurement

CFH DLG5 GBF1 PKD1L1 LAMA5 JARID2 BPTF CELSR2 YAP1 MTTP

6.84e-048699910EFO_0004735
Diseasesevere acute respiratory syndrome, COVID-19

RELN MYRIP ABLIM3 PREX2 JARID2 PXDN UNC13C

7.85e-04447997EFO_0000694, MONDO_0100096
Diseasetotal blood protein measurement

CFH FLI1 BACH2 SETD2 SBF2 MACF1 UBASH3B

8.06e-04449997EFO_0004536
Diseasemood disorder

RELN FLRT3

8.48e-0413992EFO_0004247
Diseaseceliac disease

BACH2 FRMD4B ZFP36L1 MTTP

8.72e-04126994EFO_0001060
Diseasemultiple sclerosis

FLI1 BACH2 USP31 FCRL1 RNASEL FCRL3 ZFP36L1 UBASH3B

8.85e-04594998MONDO_0005301
Diseaseserum gamma-glutamyl transferase measurement

DLG5 REPS1 MTF2 BPTF SETD2 CELSR2 PLCG1 UBASH3B ARHGAP21 EXOC4

1.00e-039149910EFO_0004532
Diseasehair colour measurement

FRAS1 FANCA PXDN ZFP36L1 SBF2 PLAT UNC13C QSER1

1.11e-03615998EFO_0007822
Diseasehepcidin:transferrin saturation ratio

EML6 SLITRK1

1.14e-0315992EFO_0007902
Diseasedisease progression measurement

SLC29A3 CELSR1 EIF3A

1.14e-0361993EFO_0008336
Diseasemyeloid white cell count

TCF4 DLG5 BACH2 EML6 PREX2 SETD2 SBF2 HFM1 UBASH3B CX3CR1

1.21e-039379910EFO_0007988
Diseasesleep duration

TCF4 RELN SLC29A3 GBF1 ZBTB9 MLLT10

1.41e-03362996EFO_0005271
Diseaseaspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement

RELN MLLT10 FANCA BPTF DLG1 MACF1

1.45e-03364996EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Diseaseacute kidney failure (is_marker_for)

REN PLAT

1.47e-0317992DOID:3021 (is_marker_for)
DiseaseAge-related macular degeneration

CFH CX3CR1

1.65e-0318992cv:C0242383
DiseaseC-C motif chemokine 3 measurement

CFH PLCG2

1.65e-0318992EFO_0008051
DiseaseHemorrhage

REN PLAT

2.04e-0320992C0019080
Diseasestatus epilepticus (implicated_via_orthology)

PLAT CX3CR1

2.24e-0321992DOID:1824 (implicated_via_orthology)
Diseaseskin hydration measurement

PKD1L1 ARHGAP21

2.24e-0321992EFO_0009586
Diseaseportal hypertension (biomarker_via_orthology)

DDC CX3CR1

2.46e-0322992DOID:10762 (biomarker_via_orthology)
Diseasenephrosis (biomarker_via_orthology)

CFH CX3CR1

2.46e-0322992DOID:2527 (biomarker_via_orthology)
Diseaseresponse to selective serotonin reuptake inhibitor

REPS1 KIF26B EXOC4

2.68e-0382993EFO_0005658
Diseasenon-high density lipoprotein cholesterol measurement

REPS1 KANK2 BPTF CELSR2 MTTP ATG4C HFM1 UBASH3B

2.78e-03713998EFO_0005689
Diseaseneuroimaging measurement, brain volume measurement

TCF4 REPS1 KIF26B MLLT10 BPTF

2.81e-03286995EFO_0004346, EFO_0006930
DiseaseLynch syndrome (is_implicated_in)

TCF4 RNASEL

2.93e-0324992DOID:3883 (is_implicated_in)
DiseaseAutism Spectrum Disorders

RELN GABRQ JARID2

2.96e-0385993C1510586
Diseaseneuroimaging measurement

TCF4 RELN KIF26B MLLT10 FRMD4B NCOR1 CELSR1 MACF1 QSER1 EXOC4

3.16e-0310699910EFO_0004346
DiseaseInvolutional paraphrenia

RELN FREM3

3.18e-0325992C1571983
DiseasePsychosis, Involutional

RELN FREM3

3.18e-0325992C1571984
DiseaseInvolutional Depression

RELN FREM3

3.18e-0325992C0011574

Protein segments in the cluster

PeptideGeneStartEntry
DSLTGLRSSYASQHS

PKP4

381

Q99569
RSSTSSREALHTAGY

ABLIM3

546

O94929
SSHSTSGFASTFRED

BACH2

246

Q9BYV9
HVTSNASDSESSYRG

DLG1

681

Q12959
NHSESSSNRSYRDSG

FLRT3

626

Q9NZU0
SVLSSNFTYHTSDGD

CX3CR1

336

P49238
INSSRSSQESYAHGT

CFH

881

P08603
LSLDEQSSSYASSHS

CELSR1

2811

Q9NYQ6
LEDDQSGSYASTHSS

CELSR2

2726

Q9HCU4
SESASRNHYGSAREQ

FLG

1611

P20930
DSSRHSASQYGQDTI

FLG

3096

P20930
FSSLSQDSAYHSGIQ

FLG

3931

P20930
YSSDQAHSSVERAGL

DDC

186

P20711
SHLLSSSDAEGNYRD

BPTF

1611

Q12830
FNADSGYSIHSDSES

CCDC14

86

Q49A88
GHSRDYDFTSTTTNE

ATG4C

421

Q96DT6
HDRESYNNSGSSSRK

AFF4

151

Q9UHB7
NTYSELRQHSCSSSG

CPXCR1

286

Q8N123
TSSSISRHYGLSDSR

MTF2

466

Q9Y483
DLSSVSQSQSYSSGH

QSER1

416

Q2KHR3
LGVYLSSAATRNSHS

OR7A5

256

Q15622
YGSSLDTTSSTIHNN

OOSP3

116

A0A2R8YFM6
ANHYSSDSQLSAGLT

ANKRD34B

366

A5PLL1
TGRRSSGHSEYSDSE

FLG2

1796

Q5D862
HDSRTYLVNSSDSGS

KATNBL1

116

Q9H079
SYSHDGSNSLKDRFT

FRAS1

2386

Q86XX4
SSSDADDHYSLQSGT

MXD4

176

Q14582
GRQTSRHSSVQYSSE

LYSMD3

126

Q7Z3D4
TDESSSSSLHATRTY

FXR2

411

P51116
AGKDHSASFSNSSYL

SBF2

1291

Q86WG5
SDLPSTSEQARHSYG

GABRQ

451

Q9UN88
ERLSYPSHSSADINS

TCF4

261

P15884
AHLSSDPDYSSSSEQ

KIF26B

846

Q2KJY2
VAHNYDRFSRSGSSS

MTTP

601

P55157
SETTARTYSHLNIAG

PFKL

146

P17858
SDYSEMRATHGSNSL

DLG5

1241

Q8TDM6
SHNTYLTGDQLRSES

PLCG2

326

P16885
TTRDSYQFGGSLSSH

LAMA5

3336

O15230
DVTEARLSFYSGHSS

PLPP2

156

O43688
ISNSRHTVNYGSDLT

KRT20

46

P35900
DYNSLTRSEHSHSTT

ITGB4

1491

P16144
TSHAVSGSSRYDSNE

LRRC66

561

Q68CR7
SHFQSLSYSLAERSS

MACF1

4091

Q9UPN3
SGTNSELSYTFSHAS

PCDHB12

271

Q9Y5F1
ISESFGSSRLSSYHN

RELN

711

P78509
SAYSNDNELDSHIGS

HFM1

176

A2PYH4
VETARSHQRSSSESY

PI4K2A

451

Q9BTU6
RNAYSSSHLEPESSS

FRMD4B

671

Q9Y2L6
HYSTAGSSSVREINL

EXOC4

246

Q96A65
HTSRTLSFGSDLNYA

EIF3A

486

Q14152
SFNLSLTEEHSGNYS

FCRL1

261

Q96LA6
DSSEAYANHSSSFIG

FANCA

81

O15360
AYNTTSHTDQSSRLS

FLI1

201

Q01543
SFNLSLTAEHSGNYS

FCRL3

436

Q96P31
SSLNDTYHSRDSSFR

MARCHF7

31

Q9H992
DSSISNLMDYSHRSG

MARCHF7

151

Q9H992
SHRSGDFTTSSYVQD

MARCHF7

161

Q9H992
HQNDVSLDRGYTSDS

GBF1

1306

Q92538
SLCSNASGDSRHSAY

KANK2

86

Q63ZY3
NLSTGSQSFYLEHTD

EML6

1401

Q6ZMW3
SSRHSEAGSEYTVVS

C4orf54

866

D6RIA3
DHSTLDGYSRRTTLS

DKK1

161

O94907
SSSSHVYSREGEFTV

PKD1L1

636

Q8TDX9
ASRSQSSHSYDDSTL

CTNND1

856

O60716
SSARYGSHDGSSTVA

JARID2

1106

Q92833
SSSSYSGDISRHHNS

ABCC1

916

P33527
DYVTLSDQDSHSGSS

FAM83G

586

A6ND36
SYQHGRDQTTTSDTF

FREM3

901

P0C091
EDDFQHSSNSTYRTT

SLC29A3

6

Q9BZD2
SVSDDLTSVTNHGYR

TRIM35

316

Q9UPQ4
NEQESRHAASYSSDS

REPS1

106

Q96D71
RHAASYSSDSENQGS

REPS1

111

Q96D71
LGSASQSYSHTTRAS

RFX1

421

P22670
DASDSSSYKHNGTEL

REN

131

P00797
DSSSSLSSHRYETPS

NCOR1

1956

O75376
SRENSHLVTFYGSES

RNASEL

411

Q05823
SEALNSAISHTGRTY

SNX33

436

Q8WV41
RQDYASTSASVSRHS

SLAIN1

286

Q8ND83
LHNSEIGSSSYSRIS

POM121L2

541

Q96KW2
SYDQSLSDSSSHSQD

MLLT10

211

P55197
SFTDSDLRNDSYSHS

MLLT10

376

P55197
DLRNDSYSHSQQSSA

MLLT10

381

P55197
SDYSIPSRTSHSDSS

CLMN

896

Q96JQ2
LSPYSHDGDSLSRSQ

PITPNM1

496

O00562
DQEGYLSSSSSSHSG

ZFP36L1

301

Q07352
SSSNLSYQSHDCSGA

SETDB2

136

Q96T68
SAYRGTHSLTESGAS

PLAT

221

P00750
KHNSPSSDDSSDYSL

ZC3H6

71

P61129
ASGDRSHYSDSQLSL

UNC13C

636

Q8NB66
DTYSRGHDSSSQSDH

RBMXL3

726

Q8N7X1
ETGTHSNSYLDTSRV

SLITRK1

601

Q96PX8
SSYHEANGNSVRSTS

STYXL2

991

Q5VZP5
YTLFSASSEGQNHSR

GEMIN5

321

Q8TEQ6
DASNVYGSTEHEARS

PXDN

911

Q92626
LNSGTYHSRDESTDS

YAP1

386

P46937
YHSRDESTDSGLSMS

YAP1

391

P46937
DTRSEHSYSESGASG

TEX264

256

Q9Y6I9
ISSSHNTYLTGDQFS

PLCG1

331

P19174
DSGHDTISNRDSYSD

PREX2

1096

Q70Z35
DAESGSHVYTFRSVS

RFPL2

321

O75678
AESGSHVYTFRSVSA

RFPL3

261

O75679
TSSYQEGRRAHEATS

nan

126

Q6ZWC4
DGYSSENTSRAHTPL

SETD2

1841

Q9BYW2
RGGNSYHALLSTTSS

ZBTB9

151

Q96C00
NVSVDYRHSETSATA

YTHDC2

496

Q9H6S0
TFSLSRESSLQYHSG

TBX4

521

P57082
HGSYSILNTSSSNSL

UBASH3B

326

Q8TF42
RNLSSSYQEPSDSHS

USP31

916

Q70CQ4
YSGHSDGISSSRSQA

ARHGAP21

351

Q5T5U3
YSVDTSASTFNHRGS

SCML4

246

Q8N228
QGSTAYSSRSSAAHR

MYOM1

41

P52179
ISGSDSTFYRQSEGH

MYRIP

171

Q8NFW9