Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenodecreased thyrotroph cell number

PROP1 PITX1

2.23e-058132MP:0008338
MousePhenoabnormal thyrotroph morphology

PROP1 PITX1

7.22e-0514132MP:0008326
DomainHomeobox_CS

ESX1 PROP1 PITX1

3.26e-04186143IPR017970
DomainHomeobox

ESX1 PROP1 PITX1

6.38e-04234143PF00046
DomainHOMEOBOX_1

ESX1 PROP1 PITX1

6.54e-04236143PS00027
DomainHOX

ESX1 PROP1 PITX1

6.62e-04237143SM00389
DomainHomeobox_dom

ESX1 PROP1 PITX1

6.79e-04239143IPR001356
DomainHOMEOBOX_2

ESX1 PROP1 PITX1

6.79e-04239143PS50071
Domain-

ESX1 PROP1 PITX1

1.11e-032831431.10.10.60
DomainHomeodomain-like

ESX1 PROP1 PITX1

1.75e-03332143IPR009057
DomainSAM

EPHB6 CASKIN2

1.93e-0388142SM00454
DomainSAM_DOMAIN

EPHB6 CASKIN2

2.24e-0395142PS50105
DomainSAM

EPHB6 CASKIN2

2.33e-0397142IPR001660
Domain-

EPHB6 CASKIN2

2.78e-031061421.10.150.50
DomainSAM/pointed

EPHB6 CASKIN2

3.37e-03117142IPR013761
DomainPDZ

ARHGEF11 GRID2IP

4.85e-03141142PF00595
DomainPDZ

ARHGEF11 GRID2IP

5.33e-03148142SM00228
Domain-

ARHGEF11 GRID2IP

5.47e-031501422.30.42.10
DomainPDZ

ARHGEF11 GRID2IP

5.54e-03151142PS50106
DomainPDZ

ARHGEF11 GRID2IP

5.62e-03152142IPR001478
PathwaySIG_CHEMOTAXIS

ARHGEF11 WASF1

5.95e-054542M5193
PathwayREACTOME_RAC1_GTPASE_CYCLE

ARHGEF11 WASF1

9.04e-0417542MM15599
PathwayREACTOME_RAC1_GTPASE_CYCLE

ARHGEF11 WASF1

9.99e-0418442M41809
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

ARHGEF11 EPHB6

2.00e-0326142MM15676
PathwayREACTOME_RHO_GTPASE_CYCLE

ARHGEF11 WASF1

5.57e-0343942MM15595
PathwayREACTOME_RHO_GTPASE_CYCLE

ARHGEF11 WASF1

5.85e-0345042M27078
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

ARHGEF11 EPHB6

7.24e-0350242MM14537
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

ARHGEF11 EPHB6

9.43e-0357542M29853
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

ARHGEF11 WASF1

1.19e-0264942MM15690
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

ARHGEF11 WASF1

1.46e-0272042M41838
Pubmed

Molecular basis of pituitary dysfunction in mouse and human.

PROP1 PITX1

1.31e-051216211420609
Pubmed

Tbx19, a tissue-selective regulator of POMC gene expression.

PROP1 PITX1

1.31e-051216211447259
Pubmed

Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia.

PROP1 PITX1

3.75e-052016212183375
Pubmed

Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism.

PROP1 PITX1

4.56e-05221628934515
Pubmed

Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification.

PROP1 PITX1

4.56e-052216211807026
Pubmed

TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors.

PROP1 PITX1

4.56e-052216217919533
Pubmed

Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development.

PROP1 PITX1

4.99e-052316210588713
Pubmed

Activating mutations in BRAF disrupt the hypothalamo-pituitary axis leading to hypopituitarism in mice and humans.

PROP1 PITX1

9.76e-053216233795686
Pubmed

Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development.

PROP1 PITX1

1.04e-043316210049363
Pubmed

Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation.

ARHGEF11 GRID2IP

1.10e-043416230726710
Pubmed

SOX2 regulates the hypothalamic-pituitary axis at multiple levels.

PROP1 PITX1

1.17e-043516222945632
Pubmed

Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors.

PROP1 PITX1

1.77e-044316224227653
Pubmed

Heterozygous variants in SIX3 and POU1F1 cause pituitary hormone deficiency in mouse and man.

PROP1 PITX1

1.94e-044516235951005
InteractionTEKT5 interactions

EPHB6 PROP1 PITX1

8.35e-0651163int:TEKT5
InteractionPSMB11 interactions

PROP1 PITX1

1.65e-058162int:PSMB11
InteractionTBX22 interactions

PROP1 PITX1

2.12e-059162int:TBX22
InteractionKRTAP8-1 interactions

CCDC17 PROP1 PITX1

3.13e-0579163int:KRTAP8-1
GeneFamilyPRD class homeoboxes and pseudogenes

ESX1 PROP1 PITX1

3.51e-0592133521
GeneFamilySterile alpha motif domain containing

EPHB6 CASKIN2

1.76e-0388132760
GeneFamilyPDZ domain containing

ARHGEF11 GRID2IP

5.15e-031521321220
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF11 CDIP1 SLC25A47

2.91e-05171163a474aaed3ca4cacb0ab565c35f25d92a10f531b7
ToppCellfacs-Marrow-KLS-3m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL29 WASF1 TMEM121

3.07e-051741630cf40ce9d9ad926c4909665aaa224694b5d970cb
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-bronchial_smooth_muscle_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WASF1 TMEM121 SLC25A47

3.92e-051891634dc32b463546bbe7250dddd281b92ad17ec22da1
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Airway_Smooth_Muscle|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WASF1 TMEM121 SLC25A47

3.92e-051891630d06bf0d7191d13a1c4f30a7881e7ea1093bfd6f
ToppCelldroplet-Heart-nan-18m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB6 WASF1 TMEM121

3.92e-051891630493f7b79127c207fd7ade778ef4810500495d7e
DrugRamipril [87333-19-5]; Down 200; 9.6uM; PC3; HT_HG-U133A

ARHGEF11 EPHB6 SETD1B PITX1

9.30e-061981647144_DN
DrugHomosalate [118-56-9]; Up 200; 15.2uM; MCF7; HT_HG-U133A

ARHGEF11 KLHL29 SETD1B PITX1

9.30e-061981643879_UP
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

CASKIN2 SETD1B PITX1

2.24e-041731634565_DN
DrugNifuroxazide [965-52-6]; Down 200; 14.6uM; MCF7; HT_HG-U133A

ARHGEF11 CASKIN2 PITX1

3.00e-041911632850_DN
DrugPyrithyldione [77-04-3]; Down 200; 24uM; PC3; HT_HG-U133A

CASKIN2 TMEM121 SETD1B

3.10e-041931637153_DN
DrugMuramic acid, N-acetyl [10597-89-4]; Up 200; 13.6uM; MCF7; HT_HG-U133A

ARHGEF11 WASF1 CASKIN2

3.10e-041931633262_UP
DrugConessine [546-06-5]; Down 200; 11.2uM; MCF7; HT_HG-U133A

ARHGEF11 CASKIN2 TMEM121

3.14e-041941632792_DN
DrugHydralazine hydrochloride [304-20-1]; Down 200; 20.4uM; MCF7; HT_HG-U133A

WASF1 CASKIN2 TMEM121

3.19e-041951632311_DN
DrugEsculin Hydrate [531-75-9]; Down 200; 11.8uM; PC3; HT_HG-U133A

ARHGEF11 TMEM121 PITX1

3.19e-041951636310_DN
DrugCAY10397; Up 200; 10uM; PC3; HT_HG-U133A

WASF1 TMEM121 SETD1B

3.19e-041951637087_UP
DrugCarbimazole [22232-54-8]; Down 200; 21.4uM; MCF7; HT_HG-U133A

ARHGEF11 CASKIN2 PITX1

3.19e-041951635399_DN
DrugIodipamide [606-17-7]; Up 200; 3.6uM; MCF7; HT_HG-U133A

ARHGEF11 EPHB6 PITX1

3.24e-041961635510_UP
DrugGSK-3 Inhibitor IX; Up 200; 0.5uM; PC3; HT_HG-U133A

CASKIN2 TMEM121 PITX1

3.24e-041961636559_UP
DrugAcetazolamide [59-66-5]; Down 200; 18uM; MCF7; HT_HG-U133A

ARHGEF11 CASKIN2 SETD1B

3.24e-041961631686_DN
DrugNorfloxacin [70458-96-7]; Up 200; 12.6uM; PC3; HT_HG-U133A

KLHL29 CASKIN2 SETD1B

3.34e-041981632090_UP
Drughaloperidol; Down 200; 10uM; MCF7; HT_HG-U133A

WASF1 CASKIN2 SETD1B

3.34e-041981631669_DN
Drugnordihydroguaiaretic acid; Down 200; 1uM; MCF7; HT_HG-U133A

ARHGEF11 CASKIN2 PITX1

3.34e-041981635583_DN
DrugPF-00539758-00 [351321-34-1]; Down 200; 10uM; PC3; HT_HG-U133A

ARHGEF11 CASKIN2 PITX1

3.34e-041981636421_DN
DrugMetolazone [17560-51-9]; Down 200; 11uM; PC3; HT_HG-U133A

ARHGEF11 CDIP1 PITX1

3.34e-041981636292_DN
DrugHydrochlorothiazide [58-93-5]; Down 200; 13.4uM; MCF7; HT_HG-U133A

ARHGEF11 TMEM121 PITX1

3.34e-041981634970_DN
DrugNeostigmine bromide [114-80-7]; Down 200; 13.2uM; MCF7; HT_HG-U133A

ARHGEF11 CASKIN2 SETD1B

3.34e-041981635335_DN
DrugVerapamyl hydrochloride [152-11-4]; Up 200; 8.2uM; PC3; HT_HG-U133A

ARHGEF11 KLHL29 CASKIN2

3.39e-041991636287_UP
DrugMinocycline hydrochloride [13614-98-7]; Down 200; 8uM; MCF7; HT_HG-U133A

ARHGEF11 CASKIN2 SETD1B

3.39e-041991637436_DN
DrugAmrinone [60719-84-8]; Up 200; 21.4uM; MCF7; HT_HG-U133A

EPHB6 CDIP1 SETD1B

3.39e-041991636826_UP
Diseaseheart rate

KLHL29 GRID2IP

6.47e-03225162EFO_0004326

Protein segments in the cluster

PeptideGeneStartEntry
LPPGPPMAPLPPRSH

ESX1

366

Q8N693
PALCLPPPPAPGPMG

CCDC17

436

Q96LX7
PPGHPMPQPGFIPPH

CDIP1

56

Q9H305
GAAPMPVHPPPPGPR

ARHGEF11

1086

O15085
DLPPPMLPPAPGHCS

FER1L4

156

A9Z1Z3
SPAMQPPVPPCPGPG

CASKIN2

1056

Q8WXE0
PPLPPPVPCAPPMLS

GRID2IP

801

A4D2P6
GLRPPPPPPHDMGPA

PITX1

16

P78337
PPPPGCPPGLHLLML

EPHB6

881

O15197
PLAVPPMCPVPPACP

SLC25A47

141

Q6Q0C1
PPLLPAPLASCPPPM

SETD1B

1501

Q9UPS6
PPPPLHGPPGRPHMS

TMEM121

296

Q9BTD3
APAGHLPCPPPPPML

PROP1

201

O75360
TAPGPHVPLMPPSPP

WASF1

461

Q92558
PPNGAPPLGPHPLMP

ZC3H18

261

Q86VM9
HMAGPLLPPPPPAQP

KLHL29

256

Q96CT2