Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	adenosine 5'-monophosphoramidase activity	HINT1 HINT2	4.96e-05	4	58	2	GO:0043530
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF7 ZNF33A ZNF550 ZFP30 SREBF2 ZNF286B ZNF571 ZNF232 ZNF582 ZNF583 ZFP82 ZNF835 KDM1A ZNF546	5.56e-05	1459	58	14	GO:0000977
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	MOXD1 PAM	8.25e-05	5	58	2	GO:0016715
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF7 ZNF33A ZFP30 SREBF2 ZNF286B ZNF571 ZNF232 ZNF583 ZFP82 ZNF835 KDM1A ZNF546	2.00e-04	1244	58	12	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF7 ZNF33A ZFP30 SREBF2 ZNF286B ZNF571 ZNF232 ZNF583 ZFP82 ZNF835 KDM1A ZNF546	2.43e-04	1271	58	12	GO:0000987
GeneOntologyMolecularFunction	protein serine kinase activity	TAOK2 STK36 TAOK1 PNCK MAP3K6 PLK4	6.32e-04	363	58	6	GO:0106310
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF7 ZNF33A ZNF550 ZFP30 SREBF2 ZNF286B ZNF571 ZNF232 ZNF582 ZNF583 ZFP82 ZNF546	6.33e-04	1412	58	12	GO:0000981
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR1 ITPR3	1.23e-03	18	58	2	GO:0015278
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	HDAC3 HINT1 HINT2	1.69e-03	81	58	3	GO:0016811
GeneOntologyMolecularFunction	protein kinase activity	TAOK2 STK36 MATK TAOK1 PNCK MAP3K6 PLK4	1.70e-03	600	58	7	GO:0004672
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	TAOK2 STK36 TAOK1 PNCK MAP3K6 PLK4	1.82e-03	446	58	6	GO:0004674
GeneOntologyMolecularFunction	tau-protein kinase activity	TAOK2 TAOK1	1.85e-03	22	58	2	GO:0050321
GeneOntologyMolecularFunction	MAP kinase kinase kinase activity	TAOK2 MAP3K6	2.78e-03	27	58	2	GO:0004709
Domain	-	ZNF7 ZNF33A ZNF550 ZFP30 ZNF286B ZNF571 ZNF223 ZNF232 ZNF582 ZNF583 ZFP82 ZNF835 ZNF546	1.21e-07	679	58	13	3.30.160.60
Domain	KRAB	ZNF7 ZNF33A ZNF550 ZFP30 ZNF571 ZNF223 ZNF582 ZNF583 ZFP82 ZNF546	1.36e-07	358	58	10	PS50805
Domain	KRAB	ZNF7 ZNF33A ZNF550 ZFP30 ZNF571 ZNF223 ZNF582 ZNF583 ZFP82 ZNF546	1.36e-07	358	58	10	PF01352
Domain	zf-C2H2	ZNF7 ZNF33A ZNF550 ZFP30 ZNF286B ZNF571 ZNF223 ZNF232 ZNF582 ZNF583 ZFP82 ZNF835 ZNF546	1.53e-07	693	58	13	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF7 ZNF33A ZNF550 ZFP30 ZNF286B ZNF571 ZNF223 ZNF232 ZNF582 ZNF583 ZFP82 ZNF835 ZNF546	1.55e-07	694	58	13	IPR013087
Domain	KRAB	ZNF7 ZNF33A ZNF550 ZFP30 ZNF571 ZNF223 ZNF582 ZNF583 ZFP82 ZNF546	1.80e-07	369	58	10	SM00349
Domain	KRAB	ZNF7 ZNF33A ZNF550 ZFP30 ZNF571 ZNF223 ZNF582 ZNF583 ZFP82 ZNF546	1.85e-07	370	58	10	IPR001909
Domain	ZINC_FINGER_C2H2_2	ZNF7 ZNF33A ZNF550 ZFP30 ZNF286B ZNF571 ZNF223 ZNF232 ZNF582 ZNF583 ZFP82 ZNF835 ZNF546	5.48e-07	775	58	13	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF7 ZNF33A ZNF550 ZFP30 ZNF286B ZNF571 ZNF223 ZNF232 ZNF582 ZNF583 ZFP82 ZNF835 ZNF546	5.64e-07	777	58	13	PS00028
Domain	Znf_C2H2-like	ZNF7 ZNF33A ZNF550 ZFP30 ZNF286B ZNF571 ZNF223 ZNF232 ZNF582 ZNF583 ZFP82 ZNF835 ZNF546	7.40e-07	796	58	13	IPR015880
Domain	Znf_C2H2	ZNF7 ZNF33A ZNF550 ZFP30 ZNF286B ZNF571 ZNF223 ZNF232 ZNF582 ZNF583 ZFP82 ZNF835 ZNF546	8.40e-07	805	58	13	IPR007087
Domain	ZnF_C2H2	ZNF7 ZNF33A ZNF550 ZFP30 ZNF286B ZNF571 ZNF223 ZNF232 ZNF582 ZNF583 ZFP82 ZNF835 ZNF546	8.76e-07	808	58	13	SM00355
Domain	CU2_MONOOXYGENASE_1	MOXD1 PAM	2.84e-05	3	58	2	PS00084
Domain	CU2_MONOOXYGENASE_2	MOXD1 PAM	2.84e-05	3	58	2	PS00085
Domain	Cu2_monoox_C	MOXD1 PAM	2.84e-05	3	58	2	IPR024548
Domain	Cu2_ascorb_mOase_N	MOXD1 PAM	2.84e-05	3	58	2	IPR000323
Domain	PHM/PNGase_F_dom	MOXD1 PAM	2.84e-05	3	58	2	IPR008977
Domain	-	MOXD1 PAM	2.84e-05	3	58	2	2.60.120.310
Domain	Cu2_monooxygen	MOXD1 PAM	2.84e-05	3	58	2	PF01082
Domain	Cu2_monoox_C	MOXD1 PAM	2.84e-05	3	58	2	PF03712
Domain	Cu2_ascorb_mOase-like_C	MOXD1 PAM	2.84e-05	3	58	2	IPR014784
Domain	-	MOXD1 PAM	2.84e-05	3	58	2	2.60.120.230
Domain	HIT	HINT1 HINT2	5.66e-05	4	58	2	PF01230
Domain	Histidine_triad_HIT	HINT1 HINT2	9.42e-05	5	58	2	IPR001310
Domain	Histidine_triad_CS	HINT1 HINT2	9.42e-05	5	58	2	IPR019808
Domain	HIT_2	HINT1 HINT2	9.42e-05	5	58	2	PS51084
Domain	RIH_assoc	RYR1 ITPR3	1.41e-04	6	58	2	PF08454
Domain	HIT_1	HINT1 HINT2	1.41e-04	6	58	2	PS00892
Domain	RIH_assoc-dom	RYR1 ITPR3	1.41e-04	6	58	2	IPR013662
Domain	RYDR_ITPR	RYR1 ITPR3	1.41e-04	6	58	2	PF01365
Domain	RIH_dom	RYR1 ITPR3	1.41e-04	6	58	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 ITPR3	1.41e-04	6	58	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 ITPR3	1.41e-04	6	58	2	IPR015925
Domain	Ins145_P3_rec	RYR1 ITPR3	1.41e-04	6	58	2	PF08709
Domain	-	RYR1 ITPR3	1.41e-04	6	58	2	1.25.10.30
Domain	Protein_kinase_ATP_BS	TAOK2 STK36 MATK TAOK1 PNCK MAP3K6 PLK4	1.65e-04	379	58	7	IPR017441
Domain	HIT-like	HINT1 HINT2	3.36e-04	9	58	2	IPR011146
Domain	-	HINT1 HINT2	3.36e-04	9	58	2	3.30.428.10
Domain	MIR	RYR1 ITPR3	4.20e-04	10	58	2	PS50919
Domain	MIR	RYR1 ITPR3	4.20e-04	10	58	2	PF02815
Domain	MIR	RYR1 ITPR3	4.20e-04	10	58	2	SM00472
Domain	MIR_motif	RYR1 ITPR3	4.20e-04	10	58	2	IPR016093
Domain	PROTEIN_KINASE_ATP	TAOK2 STK36 MATK TAOK1 PNCK MAP3K6 PLK4	5.27e-04	459	58	7	PS00107
Domain	Prot_kinase_dom	TAOK2 STK36 MATK TAOK1 PNCK MAP3K6 PLK4	7.66e-04	489	58	7	IPR000719
Domain	PROTEIN_KINASE_DOM	TAOK2 STK36 MATK TAOK1 PNCK MAP3K6 PLK4	8.03e-04	493	58	7	PS50011
Domain	S_TKc	TAOK2 STK36 TAOK1 PNCK MAP3K6 PLK4	8.43e-04	359	58	6	SM00220
Domain	PROTEIN_KINASE_ST	TAOK2 STK36 TAOK1 PNCK MAP3K6 PLK4	8.81e-04	362	58	6	PS00108
Domain	Pkinase	TAOK2 STK36 TAOK1 PNCK MAP3K6 PLK4	1.15e-03	381	58	6	PF00069
Domain	Kinase-like_dom	TAOK2 STK36 MATK TAOK1 PNCK MAP3K6 PLK4	1.39e-03	542	58	7	IPR011009
Domain	Sulfatase	PIGG ARSI	1.40e-03	18	58	2	PF00884
Domain	Sulfatase_N	PIGG ARSI	1.40e-03	18	58	2	IPR000917
Domain	zf-C2H2_6	ZFP30 ZNF571 ZNF582 ZFP82 ZNF546	2.88e-03	314	58	5	PF13912
Domain	Alkaline_phosphatase_core	PIGG ARSI	4.16e-03	31	58	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	PIGG ARSI	4.16e-03	31	58	2	IPR017849
Domain	-	PIGG ARSI	4.16e-03	31	58	2	3.40.720.10
Domain	Ser/Thr_kinase_AS	TAOK2 STK36 TAOK1 PNCK MAP3K6	4.96e-03	357	58	5	IPR008271
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	APAF1 RYR1 ITPR3	3.46e-05	19	48	3	M47760
Pathway	PID_P38_MKK3_6PATHWAY	TAOK2 TAOK1 MAP3K6	9.12e-05	26	48	3	M20
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	STK36 SEMA4B ZFP30 NUP210 ZNF286B TAOK1 NCEH1 LRRC14	2.07e-06	493	60	8	15368895
Pubmed	Histidine triad nucleotide-binding proteins HINT1 and HINT2 share similar substrate specificities and little affinity for the signaling dinucleotide Ap4A.	HINT1 HINT2	2.93e-06	2	60	2	31990367
Pubmed	Sterol-regulatory-element binding protein inhibits upstream stimulatory factor-stimulated hepatic lipase gene expression.	LIPC SREBF2	2.93e-06	2	60	2	15721010
Pubmed	Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells.	TAOK2 TAOK1	2.93e-06	2	60	2	28830982
Pubmed	Common allosteric mechanisms between ryanodine and inositol-1,4,5-trisphosphate receptors.	RYR1 ITPR3	2.93e-06	2	60	2	21150295
Pubmed	Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades.	TAOK2 TAOK1	8.77e-06	3	60	2	9786855
Pubmed	TAO kinases mediate activation of p38 in response to DNA damage.	TAOK2 TAOK1	8.77e-06	3	60	2	17396146
Pubmed	Growth factor-induced phosphorylation of sterol regulatory element-binding proteins inhibits sumoylation, thereby stimulating the expression of their target genes, low density lipoprotein uptake, and lipid synthesis.	HDAC3 SREBF2	8.77e-06	3	60	2	18403372
Pubmed	Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease.	TAOK2 TAOK1	8.77e-06	3	60	2	23585562
Pubmed	The dual role of LSD1 and HDAC3 in STAT5-dependent transcription is determined by protein interactions, binding affinities, motifs and genomic positions.	HDAC3 KDM1A	8.77e-06	3	60	2	27651463
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF7 ZNF33A ZNF550 ZNF583 ZFP82	1.56e-05	181	60	5	37372979
Pubmed	Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.	RYR1 ITPR3	1.75e-05	4	60	2	22100703
Pubmed	Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain.	TAOK2 TAOK1	1.75e-05	4	60	2	10497253
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TAOK2 STK36 SEMA4B SZT2 RTTN FRYL LRRC14 PIGG RYR1 ITPR3	1.79e-05	1105	60	10	35748872
Pubmed	Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TAOK2 RALGAPA1 NUP210 FRYL	2.77e-05	100	60	4	10048485
Pubmed	Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38.	TAOK2 TAOK1	2.92e-05	5	60	2	13679851
Pubmed	The histidine triad protein Hint is not required for murine development or Cdk7 function.	HINT1 HINT2	2.92e-05	5	60	2	12748294
Pubmed	Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.	TAOK2 TAOK1	2.92e-05	5	60	2	22683681
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 ITPR3	4.37e-05	6	60	2	23463619
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 ITPR3	4.37e-05	6	60	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 ITPR3	4.37e-05	6	60	2	25966694
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 ITPR3	4.37e-05	6	60	2	16844763
Pubmed	The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability.	TAOK2 TAOK1	4.37e-05	6	60	2	12639963
Pubmed	Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways.	TAOK2 TAOK1	4.37e-05	6	60	2	16893890
Pubmed	Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases.	HINT1 HINT2	6.11e-05	7	60	2	12119013
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR1 ITPR3	6.11e-05	7	60	2	11860456
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	SLC6A3 RYR1	6.11e-05	7	60	2	20962236
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR1 ITPR3	8.14e-05	8	60	2	19033399
Pubmed	Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.	ZFP30 NUP210 NCEH1 PIGG	1.09e-04	142	60	4	19851296
Pubmed	Association of genetic variants with hemorrhagic stroke in Japanese individuals.	ZFP30 NUP210 NCEH1 PIGG	1.12e-04	143	60	4	20198315
Pubmed	The repressing function of the oncoprotein BCL-3 requires CtBP, while its polyubiquitination and degradation involve the E3 ligase TBLR1.	HDAC3 KDM1A	1.31e-04	10	60	2	20547759
Pubmed	p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.	TAOK2 TAOK1 NCEH1 FRYL	1.68e-04	159	60	4	30581152
Pubmed	The environmental and genetic evidence for the association of hyperlipidemia and hypertension.	LIPC SREBF2	2.26e-04	13	60	2	19155782
Pubmed	Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity.	SREBF2 ZDHHC4	4.40e-04	18	60	2	15527767
Pubmed	Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy.	WDR75 SREBF2	5.45e-04	20	60	2	24912190
Pubmed	Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.	ZNF7 ZFP82	5.45e-04	20	60	2	7479878
Pubmed	Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.	ZNF7 ZFP82	5.45e-04	20	60	2	2542606
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	RALGAPA1 MATK ZNF286B FRYL MAP3K6 PLK4 TAB3	6.87e-04	861	60	7	36931259
Pubmed	Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells.	HDAC3 KDM1A	7.23e-04	23	60	2	21670149
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DCAF13 WDR75 NUP210 FRYL KDM1A ITPR3	9.07e-04	653	60	6	22586326
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	CADM3 HINT1 DCAF13 RDH11 NUP210 HINT2 NCEH1 ZFP82	1.04e-03	1203	60	8	29180619
Pubmed	Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk.	LIPC SREBF2	1.15e-03	29	60	2	20167577
Pubmed	Control of developmentally primed erythroid genes by combinatorial co-repressor actions.	HDAC3 KDM1A	1.23e-03	30	60	2	26593974
Pubmed	Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response.	LIPC SREBF2	1.32e-03	31	60	2	20031551
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	TAOK2 STK36 DSCAML1	1.49e-03	130	60	3	12421765
Pubmed	Diversification of stem cell molecular repertoire by alternative splicing.	NUP210 APAF1	1.68e-03	35	60	2	16183747
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ACP7 ZNF550 ZFP30 ZNF571 ZNF223 ZNF582 ZNF583 ZFP82 ZNF835 RYR1 ZNF546	3.69e-07	1192	60	11	chr19q13
Cytoband	19q13.43	ZNF550 ZNF582 ZNF583 ZNF835	5.41e-06	87	60	4	19q13.43
Cytoband	19q13.12	ZFP30 ZNF571 ZFP82	1.19e-04	72	60	3	19q13.12
Cytoband	19q13.2	ACP7 ZNF223 ZNF546	1.32e-03	164	60	3	19q13.2
Cytoband	11p15.4	OR52E8 OR52Z1P OR52J3	2.32e-03	200	60	3	11p15.4
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF7 ZNF33A ZNF550 ZFP30 ZNF286B ZNF571 ZNF223 ZNF232 ZNF582 ZNF583 ZFP82 ZNF835 ZNF546	4.82e-09	718	42	13	28
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	TAOK2 TAOK1 MAP3K6	2.28e-05	24	42	3	654
GeneFamily	Olfactory receptors, family 52	OR52E8 OR52Z1P OR52J3	1.99e-04	49	42	3	165
Drug	Molindone hydrochloride [15622-65-8]; Down 200; 12.8uM; MCF7; HT_HG-U133A	TAOK2 DCAF13 MATK NUP210 SREBF2 LRRC14 PLK4	8.14e-07	199	59	7	7337_DN
Drug	closantel	MOXD1 HINT1 HINT2	4.64e-06	13	59	3	CID000042574
Drug	9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2; Down 200; 10uM; PC3; HT_HG-U133A	RALGAPA1 HDAC3 MOXD1 APAF1 PCGF3 PLK4	1.23e-05	198	59	6	7557_DN
Drug	phomallenic acid C	HINT1 HINT2	1.98e-05	3	59	2	CID011608761
Disease	autism spectrum disorder (implicated_via_orthology)	TAOK2 SLC6A3 WDR75 TAOK1 DSCAML1 ITPR3	2.83e-07	152	52	6	DOID:0060041 (implicated_via_orthology)
Disease	Gamstorp-Wohlfart syndrome (implicated_via_orthology)	HINT1 HINT2	3.05e-06	2	52	2	DOID:0050526 (implicated_via_orthology)
Disease	Developmental delay (disorder)	SZT2 TAOK1 KDM1A	3.84e-05	37	52	3	C0424605
Disease	Charcot-Marie-Tooth disease (is_implicated_in)	CADM3 ITPR3	1.99e-04	12	52	2	DOID:10595 (is_implicated_in)
Disease	TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)	SLC6A3 HINT1	1.99e-04	12	52	2	C1861063
Disease	central nervous system disease (implicated_via_orthology)	TAOK2 TAOK1	3.60e-04	16	52	2	DOID:331 (implicated_via_orthology)
Disease	Hypercholesterolemia, Familial	LIPC SREBF2	4.58e-04	18	52	2	C0020445
Disease	Primary microcephaly	RTTN PLK4	6.88e-04	22	52	2	C0431350
Disease	energy expenditure	MOXD1 MATK	1.04e-03	27	52	2	EFO_0005109
Disease	cholesterol to total lipids in very large HDL percentage	LIPC TOMM40L	1.37e-03	31	52	2	EFO_0022243
Disease	Global developmental delay	SZT2 TAOK1 KDM1A	1.68e-03	133	52	3	C0557874
Disease	cholesterol in small HDL measurement	LIPC TOMM40L	1.85e-03	36	52	2	EFO_0022226
Disease	mitochondrial DNA measurement	TAOK1 PCGF3 S1PR4 ITPR3	2.67e-03	328	52	4	EFO_0006312
Disease	Anxiety States, Neurotic	SLC6A3 PAM	2.75e-03	44	52	2	C0376280
Disease	Anxiety Disorders	SLC6A3 PAM	2.75e-03	44	52	2	C0003469
Disease	Anxiety neurosis (finding)	SLC6A3 PAM	2.75e-03	44	52	2	C1279420

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLGEIHTGHHSTIQY	APAF1	831	O14727
LTGRYQIHTGLQHSI	ARSI	101	Q5FYB1
VHTHHLGKVVSGYRV	PAM	236	P19021
LGHYLIRHKGTYLTH	CADM3	351	Q8N126
HTILGKTVYTGIDHH	DCAF13	151	Q9NV06
RIVIHQSHPLQYIGH	PCGF3	56	Q3KNV8
FVHLLATHGRHVQYL	ITPR3	1286	Q14573
TIPHHIHILVGSLYV	OR52Z1P	251	P0C646
GYTRLHILNGTHIHI	ACP7	396	Q6ZNF0
GSTTLLVSYRHGHVH	NUP210	616	Q8TEM1
GAQSVYHLHIHVLGG	HINT2	141	Q9BX68
VIHYRVLHRDGHLTI	MATK	166	P42679
LQGLGYLHDNHIVHR	MAP3K6	756	O95382
VSNLIHYLGLSHHLL	NCEH1	46	Q6PIU2
TLLHIYFHHQTLGQT	FRYL	2946	O94915
QLSRSHVHLIGYSLG	LIPC	156	P11150
QSVYHVHLHVLGGRQ	HINT1	106	P49773
IHEIGHSLGLYHVFR	PAPPA	561	Q13219
PHRLALTHSLVLHYG	HDAC3	26	O15379
LGAVSYLHSLGIVHR	PNCK	121	Q6P2M8
TVLVHRVHSYLERHG	KDM1A	246	O60341
HVKHHSALGYGLVTL	CALHM6	11	Q5R3K3
PHIRHVHANGTLQLY	DSCAML1	71	Q8TD84
HSRLIVLHYNHSGRL	S1PR4	21	O95977
GHRTLLYGHAILLRH	RYR1	96	P21817
THRFGHNIPQYIHII	OR52E8	266	Q6IFG1
LTHRFGHQIPGYIHI	OR52J3	261	Q8NH60
HVIGHHAVSPYSIVL	RTTN	991	Q86VV8
AHLVLRHGYHLTTFL	SZT2	3061	Q5T011
IGVNHLGHFLLTHLL	RDH11	146	Q8TC12
LLHINLGIHSPSSYH	TAB3	71	Q8N5C8
VHRVPGLHHTYDVLF	SEMA4B	451	Q9NPR2
ITHGALQGLAYLHSH	TAOK1	131	Q7L7X3
VTHGALQGLAYLHSH	TAOK2	131	Q9UL54
HLHLPRSGTTVLHAY	DIP2C-AS1	196	Q8N8Z3
ITGMLYLHSHGILHR	PLK4	121	O00444
YLHSHGILHRDLTLS	PLK4	126	O00444
RAHTYRLLGHLLQHS	STK36	1126	Q9NRP7
IAVHVQRAHGGHILY	CNBD1	111	Q8NA66
GYHLTLHQRIHTGEK	ZFP30	366	Q9Y2G7
CYISALHIHQRVHLG	ZNF223	186	Q9UK11
ARTVITHLVNHLGHY	RALGAPA1	1506	Q6GYQ0
IQRGHESLVHHILLY	MOXD1	226	Q6UVY6
HILHGHRNLVTGIQL	WDR75	51	Q8IWA0
RAVHGLLHYLFHTRN	ZDHHC4	51	Q9NPG8
YFERGVLHLHQSHGI	SLC6A3	216	Q01959
AALAYHRLHQLHITG	SREBF2	666	Q12772
GYQLTLHLRTHTGEI	ZNF546	481	Q86UE3
RVSHLTVHYRIHTGE	ZNF582	406	Q96NG8
YHKSLLTRHQIIHTG	ZNF33A	506	Q06730
HRSTYLIQHSVIHTG	ZNF550	381	Q7Z398
SRGYHLILHHRIHTG	ZFP82	376	Q8N141
SLTHRLVLGGELVYH	TOMM40L	171	Q969M1
SNRSYLIQHHIVHTG	ZNF835	456	Q9Y2P0
IYNSHLVVHQRVHSG	ZNF232	286	Q9UNY5
HLVQHQLIHTGVRPY	ZNF286B	341	P0CG31
LILHYLGLDHIGHIS	PIGG	211	Q5H8A4
FILGSHLTYHQRVHT	ZNF571	316	Q7Z3V5
FSHRGYLIVHQRIHT	ZNF583	361	Q96ND8
LIHHQRIHTGERPYG	ZNF7	321	P17097
RFQHLASLRLHYVHG	LRRC14	246	Q15048