Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	ARM-type_fold	HSPBP1 HUWE1 AOPEP IPO11	1.55e-03	339	28	4	IPR016024
Domain	ARM-like	HSPBP1 HUWE1 IPO11	7.49e-03	270	28	3	IPR011989
Domain	Cys-rich_flank_reg_C	TPBGL LGI2	8.00e-03	90	28	2	IPR000483
Domain	LRRCT	TPBGL LGI2	8.00e-03	90	28	2	SM00082
Domain	L_dom-like	TPBGL LGI2 INSR	1.27e-02	328	28	3	IPR032675
Pathway	WP_INSULIN_SIGNALING_IN_ADIPOCYTES_NORMAL_CONDITION	AKT2 INSR	4.80e-05	8	19	2	M39447
Pathway	WP_INSULIN_SIGNALING_IN_ADIPOCYTES_DIABETIC_CONDITION	AKT2 INSR	4.80e-05	8	19	2	M39537
Pubmed	HELZ2 promotes K63-linked polyubiquitination of c-Myc to induce retinoblastoma tumorigenesis.	HELZ2 HUWE1	2.16e-06	3	30	2	34761308
Pubmed	PKB/Akt phosphorylation of ERRγ contributes to insulin-mediated inhibition of hepatic gluconeogenesis.	AKT2 INSR	4.31e-06	4	30	2	25205222
Pubmed	AKT2 maintains brain endothelial claudin-5 expression and selective activation of IR/AKT2/FOXO1-signaling reverses barrier dysfunction.	AKT2 INSR	4.31e-06	4	30	2	30574832
Pubmed	Insulin Is Required to Maintain Albumin Expression by Inhibiting Forkhead Box O1 Protein.	AKT2 INSR	4.31e-06	4	30	2	26668316
Pubmed	Insulin-Inducible SMILE Inhibits Hepatic Gluconeogenesis.	AKT2 INSR	4.31e-06	4	30	2	26340929
Pubmed	CATSPER2, a human autosomal nonsyndromic male infertility gene.	CATSPER2 STRCP1	7.18e-06	5	30	2	12825070
Pubmed	Insulin receptor signaling in cones.	AKT2 INSR	1.08e-05	6	30	2	23673657
Pubmed	Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation.	AKT2 INSR	1.08e-05	6	30	2	32464093
Pubmed	Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice.	AKT2 INSR	1.51e-05	7	30	2	18256806
Pubmed	A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.	VPS36 SPECC1L MARCHF5	1.92e-05	60	30	3	20682791
Pubmed	Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11.	HUWE1 IPO11	3.94e-05	11	30	2	11809816
Pubmed	Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome.	AOPEP INSR	5.58e-05	13	30	2	22885925
Pubmed	Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.	CXCL13 DLGAP1	1.64e-04	22	30	2	23247143
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	HELZ2 HUWE1 PITRM1 IPO11	2.10e-04	344	30	4	30333137
Pubmed	Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.	HSPBP1 HUWE1	4.45e-04	36	30	2	35379950
Pubmed	TWIST1 interacts with β/δ-catenins during neural tube development and regulates fate transition in cranial neural crest cells.	AKT2 SPECC1L	5.23e-04	39	30	2	35781329
Cytoband	15q15.3	CATSPER2 STRCP1	1.23e-04	25	30	2	15q15.3
Cytoband	Ensembl 112 genes in cytogenetic band chr15q15	CATSPER2 STRCP1	4.18e-03	147	30	2	chr15q15
Cytoband	Xq28	SLC6A8 FAM223A	5.92e-03	176	30	2	Xq28
Cytoband	Ensembl 112 genes in cytogenetic band chrXq28	SLC6A8 FAM223A	8.56e-03	213	30	2	chrXq28
Coexpression	DESCARTES_FETAL_PANCREAS_CCL19_CCL21_POSITIVE_CELLS	CXCL13 TPBGL LGI2	6.17e-05	67	30	3	M40262
Coexpression	GSE18281_PERIMEDULLARY_CORTICAL_REGION_VS_WHOLE_CORTEX_THYMUS_DN	SPAG9 GTPBP1 SLC43A1 INSR	7.00e-05	195	30	4	M7263
Coexpression	GSE18791_CTRL_VS_NEWCASTLE_VIRUS_DC_16H_UP	VPS36 DCAF13 PRDM15 IPO11	7.57e-05	199	30	4	M4278
Coexpression	GSE11961_MARGINAL_ZONE_BCELL_VS_GERMINAL_CENTER_BCELL_DAY7_UP	HELZ2 CXCL13 CATSPER2 SLC43A1	7.57e-05	199	30	4	M9320
Coexpression	GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN	IRF2 AKT2 GTPBP1 MARCHF5	7.72e-05	200	30	4	M3969
Coexpression	GSE27786_LSK_VS_MONO_MAC_UP	HUWE1 MARCHF5 SLC43A1 IPO11	7.72e-05	200	30	4	M4763
Coexpression	LAKE_ADULT_KIDNEY_C3_PROXIMAL_TUBULE_EPITHELIAL_CELLS_S1_S2	SPAG9 ACMSD AOPEP INSR	1.13e-04	221	30	4	M39222
Disease	mean reticulocyte volume	DNAH2 HELZ2 DLGAP1 SPECC1L GTPBP1 IPO11	7.04e-05	799	27	6	EFO_0010701
Disease	S-6-hydroxywarfarin to S-warfarin ratio measurement	DLGAP1 SPAG9 CSMD3	7.12e-05	88	27	3	EFO_0803332
Disease	diffusing capacity of the lung for carbon monoxide	CXCL13 IPO11 INSR	9.22e-05	96	27	3	EFO_0009369
Disease	prostate adenocarcinoma (is_implicated_in)	AKT2 INSR	1.52e-04	20	27	2	DOID:2526 (is_implicated_in)
Disease	high grade glioma (implicated_via_orthology)	AKT2 INSR	7.45e-04	44	27	2	DOID:3070 (implicated_via_orthology)
Disease	Antithrombotic agent use measurement	IRF2 AOPEP	1.16e-03	55	27	2	EFO_0009925
Disease	polycystic ovary syndrome	AOPEP INSR	1.38e-03	60	27	2	EFO_0000660
Disease	cancer (implicated_via_orthology)	TSPAN12 AKT2 VPS36	1.84e-03	268	27	3	DOID:162 (implicated_via_orthology)
Disease	Uterine leiomyoma	DNAH2 TSPAN12	3.14e-03	91	27	2	HP_0000131
Disease	alpha fetoprotein measurement	AKT2 ACMSD	3.78e-03	100	27	2	EFO_0010583
Disease	type 2 diabetes mellitus (implicated_via_orthology)	AKT2 INSR	4.15e-03	105	27	2	DOID:9352 (implicated_via_orthology)
Disease	hepatocellular carcinoma (biomarker_via_orthology)	AKT2 INSR	4.39e-03	108	27	2	DOID:684 (biomarker_via_orthology)
Disease	Drug Use Disorders	CSMD3 INSR	4.96e-03	115	27	2	C0013222
Disease	Drug Dependence	CSMD3 INSR	4.96e-03	115	27	2	C1510472
Disease	Drug habituation	CSMD3 INSR	4.96e-03	115	27	2	C0013170
Disease	Substance Dependence	CSMD3 INSR	4.96e-03	115	27	2	C0038580
Disease	Substance Use Disorders	CSMD3 INSR	4.96e-03	115	27	2	C0038586
Disease	Substance-Related Disorders	CSMD3 INSR	4.96e-03	115	27	2	C0236969
Disease	Drug abuse	CSMD3 INSR	4.96e-03	115	27	2	C0013146
Disease	Organic Mental Disorders, Substance-Induced	CSMD3 INSR	4.96e-03	115	27	2	C0029231
Disease	Prescription Drug Abuse	CSMD3 INSR	4.96e-03	115	27	2	C4316881

Protein segments in the cluster

Peptide	Gene	Start	Entry
DSPDEREEWMRAIQM	AKT2	91	P31751
LMEMDQDDRVWPRDS	CATSPER2	481	Q96P56
DNNLRCMWMIEVDPG	CSMD3	1436	Q7Z407
DSLLRQMWERMDEGC	GTPBP1	76	O00178
NEMVRTERPDWQNVM	SPECC1L	1091	Q69YQ0
ENCWDPEVRIREMDQ	ACMSD	51	Q8TDX5
QAERDRMEGWCQQME	DLGAP1	801	O14490
RMEGWCQQMEREERE	DLGAP1	806	O14490
WRRLQDEMQCSPEEM	AOPEP	536	Q8N6M6
ILDMRTNTICWNPME	DCAF13	236	Q9NV06
MRMRPWLEEQINSNT	IRF2	6	P14316
WTEMIRASRENPAMQ	SPAG9	531	O60271
MWVDRMDNITQPERR	IPO11	831	Q9UI26
DEQRRWPGCDQQDEM	SLC43A1	61	O75387
ERMDAMLLWQCPTQG	FAM223A	46	Q8IWN6
MPDQALQQMLDRSCW	MARCHF5	1	Q9NX47
CPERVTDLMRMCWQF	INSR	1261	P06213
TVENMSWMLVCDRPE	HUWE1	71	Q7Z6Z7
CVDPQAEWIQRMMEV	CXCL13	76	O43927
CRMDTWDPRIMVPIN	HELZ2	1206	Q9BYK8
PGEWENACNEMQRML	DNAH2	3776	Q9P225
PMSEERRQWLQEAMS	HSPBP1	66	Q9NZL4
MGFWCRMSENQEQEE	SNX11	1	Q9Y5W9
IAQPSMENCMVLEWD	LGI2	246	Q8N0V4
NEDDCNWMMLVRPAA	PRDM15	476	P57071
LCLDRNLPDMMQLWS	PITRM1	671	Q5JRX3
PRETWTRQMDFIMSC	SLC6A8	51	P48029
RLSEEMTQRRWENMP	VPS36	121	Q86VN1
MTEMDWPPDSCCVRE	TSPAN12	171	O95859
WMRNLREACRDQMEG	TPBGL	336	P0DKB5
CIWAELQRRMAMPEP	STRCP1	1231	A6NGW2